AMNA INAYAT MEDICAL COLLEGE, BIOCHEMISTRY

DEPARTMENT
Tabulation. SEQ 2.5 Marks & MCQ 3 Marks
Topics included are Cell organelles functions, Membrane
composition & their role, MembraneTransport,Signal transduction
Ph, Buffers, Water.
Q:1 Draw a labelled diagram of mitochondria and enumerate its functions .
Q:2 Young patient visited to OPD.After taking history,examination and few test he was
diagnosed as a case of heridetary spherocytosis.
What is heridetary spherocytosis?
What is the cause of this disease?
What is the treatment of this disease?
Q:3 Define Active transport ?explain different types of active transport with examples.
Q:4 Name two diseases related to lysosomal functions ?
Q:5 Write short note on Zellwegers syndrome.
Q:6 What is the difference between nucleus and nucleolus.?
Q:7 How phagocytosis takes place .what is its clinical significance?
Q:8 Describe the chemical components of cell membrane?
Q:9 Write a note on Cystic fibrosis.
Q10.What is G Protein Coupled Receptor? Illustrate the intracellular events of
activated Gprotein when the hormone is Adrenaline /Glucagon at the receptor
b Briefly write the importance of GTPase and Phosphodiestrase enzyme
Q11. A patient of Known diabetic was brought to the hospital unconscious (Coma)
His LAB findings were, Blood sugar 400 mg, pH 7.2, Bicarbonate 15 (Normal value 25)
Answer the following questions
a Which type of Acidosis he had been suffering
b Name the Acids which produced too much in above patient
c Why the level of Bicarbonate was Low
Q12. (a). Draw and label a diagram to illustrate the composition of a typical cell membrane.
(b). How are G- proteins activated in plasma membrane?
Q.13. (a). Define pH and pK.
(b). What are the causes of metabolic alkalosis and how the compensation occurs in
this case?
Q14. (a). What are the various systems which prevent change in pH of our body?
(b). Differentiate between phosphate buffer and bicarbonate buffer.
Q15. a. What is G Protein & How are G- proteins activated in plasma membrane?
b. What is the role of GTPase Enzyme?
Q16.Write the intracellular events of Gq Protein down to the cell when signal reaches to the
Membrane
Q17. a) What is respiratory acidosis? What are its causes?
b) Describe the role of lungs in maintenance of acid base balance?

Q18. a ten year old diabetic patient presents to medical emergency of Hospital in
unconscious state. His plasma pH is 7.30 and plasma bicarbonate is 15 meq/L.
(A). which type of acid base disturbance is present in this case?
(B). what do you understand by high anion gap and normal anion gap metabolic acidosis.
Give a few examples of each condition.
Q19. What do you understand by Lipid anchored protein of cell membrane?
Q20. Briefly explain the role of Lipid Rafts & Caveolae on the plasma protein
Q21 What is the role of Cardiolipin on Mitochondrial Membrane?
Q22 Describe fluid Mosaic Model of cell with the help of labelled diagram
Q23 Enlist 2nd messengers & their relevant Protein Kinases
Q24 Enumerate the biomedical importance of mitochondrial matrix & inner
Mitochondrial membrane.
Q25. Differentiate between the Cyclic AMP & Cyclic GMP on the following headings
Hormones or Ligands which stimulate them at the Membrane
Enzymes which activate them on the membrane
Name of Protein kinases activated by them
Inactivation or termination process of above second messengers
Q26..Define pH,What is the influence of excess Hydrogen ion on the structure & functions
of Proteins, how are these excess hydrogen ions are compensated normally in the plasma
Q27. Explain the body water distribution in different compartment. How water or fluid level is
Regulated to avoid dehydration?
Q28. Enumerate hormones which help to maintain water & Electrolyte balance in the
Body.
Q29. Define plasma colloidal oncotic pressure? Which one plasma protein is essential?
to maintain plasma colloidal oncotic pressure, write its mechanism also
Q30.Write the biomedical importance or application of Henderson hasselberg equation
Q31.EnumerateGlycerophospholipids which are major components of Plasma membrane
Q32.What is pH meter? Write its uses