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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Immune Formula
Immune Boost*
Summary
Immune Formula is a dietary supplement developed
and marketed by Pharmanex, LLC to support the bodys
natural immune function.* Immune Formula contains
a proprietary blend of vitamin C, echinacea, goldenseal,
and two unique immune-stimulating ingredients
arabinogalactan and beta-sitosterol. Each of these ingredients has been shown individually to boost immune
function during the cold and wet weather season and
support the bodys natural immune function.* Immune
Formula provides beneficial levels of active ingredients
correctly standardized for optimal results.
Background
The immune system is an intricate system with a
variety of functions vital to health.When functioning
properly, the immune system performs the following
important functions:
Mechanisms of Action
Immune Formula has multiple mechanisms of action
to support the bodys natural immune function.* These
mechanisms include the involvement of vitamin C,
echinacea, and arabinogalactan in cell-mediated immune
function.4, 7, 15, 1933 Secondly, beta-sitosterol appears to
modulate immune function and the inflammatory response
through its effects on the production of inflammatory
cytokines.34, 35 Lastly, arabinogalactan may support the
bodys natural protective mechanisms; it has been shown
to block bacteria and viruses from attaching and binding
to cell membranes in the liver and other organs.16, 18, 29
Arabinogalactan may also improve gastrointestinal health
by influencing two primary gut microflora, lactobacilli
and bifidobacteria.16, 29
Health Benefits
Immune Formula supports the bodys natural
immune function and may boost immune function
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
GoldensealClinical Studies
Goldenseal has been shown to speed up recovery
time in subjects with diarrhea, and decrease diarrhea
volume in clinical studies.43 In one study, 400 mg of
goldenseal (berberine sulfate) produced a significantly
higher rate of recovery from E. coli-induced diarrhea
within 24 hours of treatment and significantly lower
stool volume in subjects with cholera-induced diarrhea.
Other research has also indicated that goldenseal may
be beneficial for some forms of diarrhea.44, 45
ArabinogalactanClinical Studies
Clinical studies with arabinogalactan (ImmunEnhancer
AG), have demonstrated increased immune cell proliferation, increased levels of gut microflora, and improved
quality of life in patients with acute infections.46 In a
double-blind, placebo-controlled, randomized trial in
healthy adult females, assessment by quality of life
measurements showed significant improvement in overall
physical health, vitality and emotional health, including
symptoms associated with digestive function, bowel
habits, sleep and mood in the treated group compared to
placebo.46 Studies at the University of Minnesota and the
Southwest College of Naturopathic Medicine have shown
increases in total white blood cells, absolute monocyte
counts, and neutrophil counts. Consumption of arabinogalactan also produced a 47% increase in Lactobacillus
and Bifidobacterium levels in the gut. In another study,
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Graph 1
ImmunEnhancer AG vs. Echinacea
120
Echinacea
ImmunEnhancer AG
Immune cell
count
100
80
Side Effects
60
40
20
0
25
100
250
750
Proprietary Processing
The combination of quality ingredients, qualified
manufacturers, certified independent laboratory verification,
and a continuous drive to supply leading edge products,
ensure our representatives and consumers the highest quality
products available in the industry. Immune Formula is
standardized to provide a 6:1 extract of Echinacea
(Echinacea purpurea) Root and a 4:1 extract of Goldenseal
(Hydrastis candensis).The aribinogalactan extract found
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
5.
6.
7.
8.
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10.
Immune Formula is a dietary supplement for individuals who want to support the bodys natural immune
function.Take one (1) capsule one to three (3) times daily.
Use as needed for up to two (2) weeks, followed by a
resting period of at least one week.
11.
12.
How Supplied
Immune Formula is supplied in a 30-day supply of
60 capsules. Each natural gelatin capsule contains 200 mg
of vitamin C (as calcium ascorbate), 225 mg of Echinacea
(Echinacea purpurea) Root extract, 125 mg of Goldenseal
(Hydrastis canensis) Root, 100 mg of Arabinogalacatan,
and 30 mg of Beta-Sitosterol.
13.
14.
15.
Storage
Store in a cool, dry place. Avoid excessive heat.
Protect from light.
16.
Shelf-Life
17.
18.
Warnings
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References
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
43. Khin MU, Myo K, Nyunt NW, Aye K, Tin U. Clinical trial of
berberine in acute watery diarrhea. Br Med J (Clin Res Ed)
1985;291:16015.
44. Sack RB, Froelich J. Berberine inhibits intestinal secretory response
of Vibrio cholerae and Escherichia coli enterotoxins. Infection
and Immunity 1982;4715.
45. Kamat SA. Clinical trials with berberine hydrochloride for the
control of diarrhea in acute gastroenteritis. J Assoc Physicians
India 1967;15:525 9.
46. Larex Immunenhancer AGClinical Study Update. 2000.
Unpublished Work.
47. Anonymous. Cross-study comparisons on arabinogalactan (AG).
2000. Unpublished article.
48. Slavin J.The prebiotic benefits of arabinogalactan.Total Health
2000;22(5):24 25.
49. Cross-study comparisons on arabinogalactan (AG). 2000.
Unpublished Work.
50. Awad AB, Fink CB. Phytosterols as anticancer dietary components:
Evidence and mechanism of action. J Nutr 2000;130:21272130.
51. Bruynzeel DP, van Ketel WG,Young E, et al. Contact sensitization
by alternative topical medicaments containing plant extracts.
Contact Dermatitis 1992;27:278 9.
52. Parnham MJ. Benefit-risk assessment of the squeezed sap of the
purple coneflower (Echinacea purpurea) for long-term oral
immunostimulation. Phytomedicine 1996;3:95 102.
53. Mengs U, Clare CB, Poiley JA.Toxicity of Echinacea purpurea.
Acute, subacute and genotoxicity studies. Arzneimittelforschung
1991;41:107681.
54. Wagner H. Herbal immunostimulants for the prophylaxis and
therapy of colds and influenza.The European Journal of Herbal
Medicine 1997;3:22 30.
55. Snow JM. Hydrastic candensis L .(Ranunculaceae). 1996.
56. Chapter 5Vitamin C. In: Dietary Reference Intakes for Vitamin
C,Vitamin E, Selenium, and Carotenoids. A Report of the Panel
on Dietary Antioxidants and Related Compounds, Subcommittees
on Upper Reference Levels of Nutrients and Interpretation and
Uses of Dietary Reference Intakes, and the Standing Committee
on the Scientific Evaluation of Dietary Reference Intakes. Food
and Nutrition Board, Institute of Medicine. National Academy
Press:Washington, DC, 2000, pp. 95 185.
57. Vitamin C. In: Hathcock JN.Vitamin and Mineral Safety. Council
for Responsible Nutrition: Washington, DC, 1997, pp. 33 38.
58. Pegel KH.The importance of sitosterol and sitosterolin in human
and animal nutrition. South African Journal of Science 1997;
93:263 8.
59. Jones PJH, MacDougall DE, Ntanios F,Vanstone CA. Dietary
phytosterols as cholesterol-lowering agents in humans. Can J
Physiol Pharmacol 1997;75(3):217227.
60. Blumenthal M.The German Commission E Monograph system
for phytomedicines:A model for regulatory reform in the United
States. Phytomedicines of Europe: Chemistry and Biological
Activity. Washington, DC: American Chemical Society
1998:30 43.
61. Echinacea purpurea. In: Blumenthal M, et al, eds.The Complete
German Commission E Monographs.American Botanical Council.
Austin, Texas: Integrative Medicine Communications, 1998.
62. Bergner P. News From GermanyContraindications for Echinacea? Medical Herbalism 1990;2.
63. Anonymous. Hydrastis canadensis L. (Ranunculaceae)Goldenseal.
In: CRC Handbook of Medicinal Herbs, edited by JA Duke.
Boca Raton, FL:CRC Press, Inc., 1985, pp. 238 239.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Selection
Sourcing
Structure
Substantiation