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http://en.wikipedia.org/wiki/List_of_antibiotics
List of antibiotics
From Wikipedia, the free encyclopedia
The following is a list of antibiotics, sorted by class. The highest division is between bactericidal antibiotics and
bacteriostatic antibiotics. Bactericidals kill bacteria directly, whereas bacteriostatics prevent them from dividing.
However, these classifications are based on laboratory behavior. In practice, both can prevent a bacterial
infection.[1]
See also pathogenic bacteria for a list of antibiotics sorted by target bacteria.
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Antibiotics by class
Generic name
Brand names
Common uses[2]
Mechanism of
action
Aminoglycosides
Amikacin
Amikin
Gentamicin
Garamycin
Kanamycin
Kantrex
Neomycin
Neo-Fradin[3]
Netilmicin
Netromycin
Tobramycin
Nebcin
Paromomycin
Humatin
Streptomycin
Spectinomycin(Bs)
Infections caused by
Gram-negative bacteria,
such as Escherichia coli
and Klebsiella
particularly
Pseudomonas
aeruginosa. Effective
against Aerobic bacteria
(not obligate/facultative
anaerobes) and
tularemia.
Hearing loss
Vertigo
Kidney damage
Tuberculosis
Trobicin
Binding to the
bacterial 30S
ribosomal
subunit (some
work by binding
to the 50S
subunit),
inhibiting the
translocation of
the
peptidyl-tRNA
from the A-site
to the P-site and
also causing
misreading of
mRNA, leaving
the bacterium
unable to
synthesize
proteins vital to
its growth.
Gonorrhea
Ansamycins
Geldanamycin
Experimental, as
antitumor antibiotics
Herbimycin
Rifaximin
Xifaxan
Traveler's diarrhea
caused by E. coli
Carbacephem
Loracarbef
Lorabid
prevents
bacterial cell
division by
inhibiting cell
wall synthesis.
Discontinued
Carbapenems
Ertapenem
Doripenem
Imipenem/Cilastatin
Invanz
Doribax
Primaxin
Gastrointestinal
upset and diarrhea
Nausea
Inhibition of cell
wall synthesis
Seizures
Headache
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to this class.)
Merrem
reactions
Duricef
Cefazolin
Ancef
Same mode of
action as other
upset and diarrhea beta-lactam
Nausea (if alcohol antibiotics:
disrupt the
taken
synthesis of the
peptidoglycan
concurrently)
Allergic reactions layer of bacterial
cell walls.
Gastrointestinal
Cefalotin or Cefalothin
Keflin
(discontinued)
Cefalexin
Keflex
Distaclor
Mandol
(discontinued)
Less Gram-positive
Mefoxin
cover, improved
(discontinued)
Gram-negative cover.
Cefzil
Ceftin, Zinnat
(UK)
Same mode of
action as other
upset and diarrhea beta-lactam
Nausea (if alcohol antibiotics:
disrupt the
taken
synthesis of the
peptidoglycan
concurrently)
Allergic reactions layer of bacterial
cell walls.
Gastrointestinal
Suprax
Cefdinir
Omnicef,
Cefdiel
Cefditoren
Spectracef,
Meiact
Cefoperazone [Unlike
most third-generation
agents, cefoperazone is
active against
Pseudomonas
aeruginosa]
Cefotaxime
Cefpodoxime
Improved coverage of
Cefobid
Gram-negative
(discontinued) organisms, except
Pseudomonas. Reduced
Gram-positive cover.
But still not cover
Claforan
Mycoplasma and
Vantin
Chlamydia
Ceftazidime [Unlike
most third-generation
agents, ceftazidime is
active against
Pseudomonas
aeruginosa]
Fortaz
Ceftibuten
Cedax
Same mode of
action as other
upset and diarrhea beta-lactam
Nausea (if alcohol antibiotics:
disrupt the
taken
synthesis of the
peptidoglycan
concurrently)
layer of bacterial
Allergic reactions
cell walls.
Gastrointestinal
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Ceftizoxime
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Cefizox
(discontinued)
Cefepime
Maxipime
Covers pseudomonal
infections.
Ceftaroline fosamil
Ceftobiprole
Teflaro
Same mode of
action as other
beta-lactam
Gastrointestinal
antibiotics:
upset and diarrhea disrupt the
Allergic reaction synthesis of the
peptidoglycan
layer of bacterial
cell walls.
Zeftera
Same mode of
action as other
upset and diarrhea beta-lactam
Nausea (if alcohol antibiotics:
disrupt the
taken
synthesis of the
peptidoglycan
concurrently)
Allergic reactions layer of bacterial
cell walls.
Gastrointestinal
Glycopeptides
Teicoplanin
Vancomycin
Telavancin
Dalbavancin
Oritavancin
inhibiting
peptidoglycan
synthesis
Lincosamides(Bs)
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Clindamycin
Cleocin
Lincomycin
Lincocin
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Serious staph-,
pneumo-, and
streptococcal infections
in penicillin-allergic
patients, also anaerobic
infections; clindamycin
topically for acne
Possible C. difficilerelated
pseudomembranous
enterocolitis
Bind to 50S
subunit of
bacterial
ribosomal RNA
thereby
inhibiting protein
synthesis
Lipopeptide
Daptomycin
Cubicin
Bind to the
membrane and
cause rapid
depolarization,
resulting in a loss
of membrane
potential leading
to inhibition of
protein, DNA
and RNA
synthesis
Gram-positive
organisms
Macrolides(Bs)
Azithromycin
Zithromax,
Sumamed,
Xithrone
Nausea, vomiting,
and diarrhea
(especially at
Clarithromycin
Dirithromycin
Erythromycin
Biaxin
Streptococcal
infections, syphilis,
Dynabac
upper respiratory tract
(discontinued)
infections, lower
respiratory tract
Erythocin,
infections, mycoplasmal
Erythroped
infections, Lyme disease
Roxithromycin
Troleandomycin
Tao
(discontinued)
Telithromycin
Ketek
Pneumonia
Spiramycin
Rovamycine
Mouth infections
inhibition of
bacterial protein
Prolonged cardiac
biosynthesis by
QT interval
binding
reversibly to the
(especially
subunit 50S of
erythromycin)
the bacterial
Hearing loss
ribosome,
thereby
(especially at
inhibiting
higher doses)
translocation of
peptidyl tRNA.
Jaundice
higher doses)
Visual Disturbance,
Liver Toxicity.[4]
Monobactams
Aztreonam
Azactam
Gram-negative bacteria
Same mode of
action as other
beta-lactam
antibiotics:
disrupt the
synthesis of the
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peptidoglycan
layer of bacterial
cell walls.
Nitrofurans
Furazolidone
Furoxone
Bacterial or protozoal
diarrhea or enteritis
Nitrofurantoin(Bs)
Macrodantin,
Macrobid
Linezolid
Zyvox
neuropathy
VRSA
Serotonin
Syndrome
Posizolid
Phase II
clinical trials
Radezolid
Phase II
clinical trials
Torezolid
Phase II
clinical trials
Protein synthesis
inhibitor;
prevents the
initiation step
Penicillins
Amoxicillin
Novamox,
Amoxil
Ampicillin
Principen
(discontinued)
Azlocillin
Carbenicillin
Cloxacillin
Dicloxacillin
Flucloxacillin
Mezlocillin
Geocillin
(discontinued)
Wide range of
Tegopen
(discontinued) infections; penicillin
used for streptococcal
Dynapen
infections, syphilis, and
(discontinued) Lyme disease
Floxapen
(Sold to
European
generics
Actavis
Group)
Gastrointestinal
Same mode of
upset and diarrhea action as other
Allergy with
beta-lactam
antibiotics:
serious
disrupt the
anaphylactic
synthesis of the
peptidoglycan
reactions
layer of bacterial
Brain and kidney
cell walls.
damage (rare)
Mezlin
(discontinued)
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Methicillin
Staphcillin
(discontinued)
Nafcillin
Unipen
(discontinued)
Oxacillin
Prostaphlin
(discontinued)
Penicillin G
Pentids
(discontinued)
Penicillin V
Veetids
(Pen-Vee-K)
(discontinued)
Piperacillin
Pipracil
(discontinued)
Penicillin G
Pfizerpen
Temocillin
Negaban (UK)
(discontinued)
Ticarcillin
Ticar
(discontinued)
http://en.wikipedia.org/wiki/List_of_antibiotics
Penicillin combinations
Amoxicillin/clavulanate Augmentin
Ampicillin/sulbactam
Unasyn
Piperacillin/tazobactam
Zosyn
Ticarcillin/clavulanate
Timentin
Both
Amoxicillin/clavulanate
and
Ampicillin/sulbactam
are effective against
non-recurrent acute
Otitis media[5] Only a
few oral-antibiotics
active for skin and soft
rowspan="4"
tissue infections, one of
it is
Amoxicillin/clavulanate.
Not to be given to
children with less than
40 kilograms weight, for
children are heavier, the
dosage is same with
adult, twice daily [6]
The second
component
prevents
bacterial
resistance to the
first component
Polypeptides
Bacitracin
Inhibits
isoprenyl
pyrophosphate, a
molecule that
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carries the
building blocks
of the
peptidoglycan
bacterial cell
wall outside of
the inner
membrane[7]
Colistin
Polymyxin B
Quinolones/Fluoroquinolone
Ciprofloxacin
Cipro,
Ciproxin,
Ciprobay
Enoxacin
Penetrex
Gatifloxacin
Tequin
Gemifloxacin
Factive[8]
Levofloxacin
Levaquin
Lomefloxacin
Maxaquin
Moxifloxacin
Avelox
Nalidixic acid
NegGram
Norfloxacin
Noroxin
Ofloxacin
Floxin
(discontinued),
Ocuflox
inhibit the
bacterial DNA
Nausea (rare),
gyrase or the
irreversible damage to
topoisomerase
central nervous system IV enzyme,
(uncommon), tendinosis thereby
(rare)
inhibiting DNA
replication and
transcription.
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Trovafloxacin
Trovan
Withdrawn
Grepafloxacin
Raxar
Withdrawn
Sparfloxacin
Zagam
Withdrawn
Temafloxacin
Omniflox
Withdrawn
Sulfonamides(Bs)
Mafenide
Sulfamylon
Sulfacetamide
Sulamyd,
Bleph-10
Sulfadiazine
Micro-Sulfon
Silver sulfadiazine
Silvadene
Sulfadimethoxine
Di-Methox,
Albon
Sulfamethizole
Thiosulfil
Forte
Sulfamethoxazole
Gantanol
Sulfanilimide (archaic)
Sulfasalazine
Azulfidine
Sulfisoxazole
Gantrisin
TrimethoprimSulfamethoxazole
(Co-trimoxazole)
(TMP-SMX)
Bactrim,
Septra
Folate synthesis
inhibition. They
are competitive
inhibitors of the
enzyme
dihydropteroate
synthetase,
Nausea, vomiting, DHPS. DHPS
catalyses the
and diarrhea
conversion of
Allergy (including PABA (paraskin rashes)
aminobenzoate)
to
Crystals in urine
dihydropteroate,
Kidney failure
a key step in
Decrease in white folate synthesis.
Folate is
blood cell count
necessary for the
Sensitivity to
cell to synthesize
nucleic acids
sunlight
(nucleic acids
are essential
building blocks
of DNA and
RNA), and in its
absence cells
cannot divide.
Sulfonamidochrysoidine
Prontosil
(archaic)
Tetracyclines(Bs)
Demeclocycline
Declomycin
Doxycycline
Vibramycin
Minocycline
Minocin
Oxytetracycline
Terramycin
Syphilis, chlamydial
infections, Lyme
disease, mycoplasmal
infections, acne
rickettsial infections,
*malaria *Note: Malaria
is caused by a protist
and not a bacterium.
inhibiting the
binding of
Gastrointestinal
aminoacyl-tRNA
upset
to the
Sensitivity to
mRNA-ribosome
complex. They
sunlight
do so mainly by
Potential toxicity
binding to the
to mother and
30S ribosomal
subunit in the
fetus during
mRNA
pregnancy
translation
Enamel hypoplasia complex. But
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http://en.wikipedia.org/wiki/List_of_antibiotics
(staining of teeth;
Tetracycline
cannot be taken
permanent)
together with all
dairy products,
transient
aluminium, iron
depression of bone and zinc
growth
minerals.
potentially
Tetracycline
Sumycin,
Achromycin V,
Steclin
Lamprene
Antileprotic
Dapsone
Avlosulfon
Antileprotic
Capreomycin
Capastat
Antituberculosis
Cycloserine
Seromycin
Antituberculosis,
urinary tract infections
Ethambutol(Bs)
Myambutol
Antituberculosis
Ethionamide
Trecator
Antituberculosis
Isoniazid
I.N.H.
Antituberculosis
Pyrazinamide
Aldinamide
Antituberculosis
Inhibits peptide
synthesis
mostly Gram-positive
and mycobacteria
Reddish-orange sweat,
tears, and urine
Rifabutin
Mycobutin
Mycobacterium avium
complex
Rifapentine
Priftin
Antituberculosis
Streptomycin
Antituberculosis
Binds to the
subunit of RNA
polymerase to
inhibit
transcription
Neurotoxicity,
ototoxicity
As other
aminoglycosides
Inhibits bacterial
protein synthesis
by binding to the
50S subunit of
the ribosome
Others
Spirochaetal infections
(obsolete)
Arsphenamine
Salvarsan
Chloramphenicol(Bs)
Meningitis, MRSA,
topical use, or for
low-cost internal
treatment. Historic:
Chloromycetin
typhus, cholera.
Gram-negative,
Gram-positive,
anaerobes
Fosfomycin
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Monurol,
Monuril
Inactivates
enolpyruvyl
transferase,
thereby blocking
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cell wall
synthesis
Fusidic acid
Metronidazole
Fucidin
Flagyl
Produces toxic
free radicals that
disrupt DNA and
proteins. This
Infections caused by
Discolored urine,
non-specific
anaerobic bacteria; also
headache, metallic taste, mechanism is
amoebiasis,
nausea; alcohol is
responsible for
trichomoniasis,
contraindicated
its activity
giardiasis
against a variety
of bacteria,
amoebae, and
protozoa.
Inhibits
isoleucine
t-RNA
synthetase
(IleRS) causing
inhibition of
protein synthesis
Thiamphenicol
Gram-negative,
Gram-positive,
Rash. Lacks known
anaerobes. Widely used anemic side-effects.
in veterinary medicine.
A
chloramphenicol
analog. May
inhibit bacterial
protein synthesis
by binding to the
50S subunit of
the ribosome
Tigecycline(Bs)
Slowly Intravenous.
Indicated for
complicated skin/skin
structure infections, soft
tissues infections and
complicated intraabdominal infections.
Effective for gram
positive and negative
and also anaerob
antibiotics, against
multi-resistant
antibiotics bacteries
such as Staphylococcus
aureus (MRSA) and
Acinetobacter
baumannii, but not
Similar structure
with
tetracycline, but
5 times stronger,
big volume
distribution and
long half-time in
the body
Mupirocin
Bactroban
Platensimycin
Quinupristin/Dalfopristin Synercid
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Tigacyl
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effective for
Pseudomonas spp and
Proteus spp
Tinidazole
Tindamax
Fasigyn
Protozoal infections
Trimethoprim(Bs)
Proloprim,
Trimpex
Generic Name
Brand Names
Common Uses[2]
Mechanism of
action
References
1. ^ Pelczar, M.J., Chan, E.C.S. and Krieg, N.R. (1999) Host-Parasite Interaction; Nonspecific Host Resistance, In:
Microbiology Conceptsand Applications, 6th ed., McGraw-Hill Inc., New York, U.S.A. pp. 478-479.
2. ^ a b c d For common Uses and possible side effects reference is: Robert Berkow (ed.) The Merck Manual of Medical
Information - Home Edition. Pocket (September 1999), ISBN 0-671-02727-1.
3. ^ "Neomycin Drug Information" (http://www.uptodate.com/contents/neomycindrug-information?source=search_result&search=neomycin&selectedTitle=1~135). uptodate. Retrieved 2/11/2012.
Check date values in: |accessdate= (help)(subscription required)
4. ^ Splete, Heidi; Kerri Wachter (March 2006). "Liver toxicity reported with Ketek". Internal Medicine News.
5. ^ "Amoxicillin-sulbactam versus amoxicillin-clavulanic acid for the treatment of non-recurrent-acute otitis media in
Argentinean children" (http://www.ncbi.nlm.nih.gov/pubmed/16061111). Retrieved July 23, 2014.
6. ^ "APO-Amoxycillin and Clavulanic Acid 500mg/125 mg Tablets" (http://www.betterhealth.vic.gov.au/bhcv2
/bhcmed.nsf/pages/txcamoxy/$File/txcamoxy.pdf). Retrieved November 27, 2014.
7. ^ Mechanism of Action of Bacitracin: Complexation with Metal Ion and C55-Isoprenyl Pyrophosphate
(http://www.pnas.org/cgi/content/abstract/68/12/3223) K. John Stone and Jack L. Strominger
8. ^ "List of Antibiotics" (http://www.emedexpert.com/lists/antibiotics.shtml). Retrieved February 7, 2014.
See also
Timeline of antibiotics, listed by year of introduction
Pathogenic bacteria
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