Guidelines For Optimum Water Consumption in Bulk Drugs Manufacturing Industry PDF

Froqrai'nme Objective Series
Fiobes 117 2007
rrxJikihi
iji
OVtimum W Consumption
in Bulk Drugs
Manufacturing Industry
I_
w
ik
i
e-mail: cpcb@.nic.in Website : www.cpcb.nic.in

1!&1
iIUYA
PROGRAMME OBJECTIVE SERIES

PROBES/1 17/2007
Guidelines for
Optimum Water Consumption in Bulk Drugs
Manufacturing Industry
^^rr
CENTRAL POLLUTION CONTROL BOARD
MINISTRY OF ENVIRONMENT & FORESTS
e-mail: cpcb@nic.in Website: www.cpcb.nic.in
August 2007
CPCB, 200 Copies, 2007
Published By: Dr. B. Sengupta, Member Secretary, Central Pollution Control Board, Delhi 32
Printing Supervision & Layout: K.V. Swaminathan and Anamika Sagar
Composing & Laser Typesetting : Suresh Chander Sharma
Printed at : National Institute of Science Communication and Information Resources, CSIR,
Dr. K.S. Krishnan Marg, New Delhi
t1 wi frn5r'T
(
pari
'r
uiT
t -i
LclU rt4
Cpb
Central Pollution Control Board

(A Govt. of India Organisation)
Ministry of Environment & Forests
Phone : 22304948 / 22307233
;:j.. 9T, ^t.u..

3i"ii
J. M. MAUSKAR, IAS
Chairman
FOREWORD
The minimization of waste generation and conservation of natural
resources, especially water, has become an essential component for
sustainable development in all spheres of human life. The Government of

India's New Environmental Policy-2006 infact includes actions for the
productive consumption of water in industrial processes, amongst others
through water assessments and mandatory water audits for the identified
industries. The Central Pollution Control Board has taken up various
projects covering development of guidelines/standards for water
conservation in different industrial sectors. The Study contained in the
report covers the guidelines for the optimum utilization of water in bulk
drug manufacturing units. The findings of the Study, in brief, are that
there is a lot of scope for the reduction of water consumption in this
sector and that the adoption of the guidelines suggested can reduce water
consumption from 15 - 50% depending upon the process followed and the
products manufactured.
The able execution of the project by Mis Associated Environmental
Engineers Pvt. Ltd., Vadodara is gratefully acknowledged.

We hope that this Document would be useful for all those concerned
directly or indirectly with the conservation of water in bulk drugs
manufacturing industries.
(J.M. MAUSKAR)
August , 2007
Project Team
1.
Dr. B. Sengupta, Member Secretary
2.
Sh. N.K. Verma, Ex Additional Director -
Project co-ordination
3.
Sh. P.M. Ansari, Additional Director
Report Finalisation
4.
Dr. R.S. Mahwar, Additional Director
Report Editing
5.
Dr. D.D. Basu, Senior Scientist
Guidance and supervision
6.
Sh. Paritosh Kumar, Sr. Env. Engineer -
Report processing
7.
Sh. Dinabandhu Gouda, Env. Engineer -
Data compilation, analysis and

preparation of final report
8.
Sh. N.S. Babu, Ex Env. Engineer
Project Initiation
9.
Sh. K. P. Rathi, DEO Gr -II
Secretariat assistance
10.
Sh. Atul Sharma, JLA
11.
M/s. Associated Environmental
Overall supervision
Secretarial assistance
Project execution
Engineers (P) Ltd., Vadodara
CONTENTS
S.No. Items
Page No.
i -ii
iii
iii
ii
iv
List of Contents
List of Tables
List of Figures
List of Annexures
List of Acronyms
1.0
Introduction
1.1
1.2
1.3
01
01
02
Introduction
Objective
Methodology
2.0 Status of Bulk Drug Sector
2.1
2.2
2.3
2.4
2.5
2.6
2.7
Pharmaceutical Sector in India

Classification of Bulk Drugs
Segmentation of Pharmaceutical Industry
Bulk Drug Sector in India
04
04
06
07
2.4.1
09
Production
Findings of Industry Survey on Bulk Drug Manufacturers

Import- export trends in Indian Pharmaceutical Sector
11
11
2.6.1 Import
2.6.2 Export
11
11
Current trends in Indian Pharmaceutical Sector
12
3.0 Results and Discussions
3.1
3.2
Questionnaire Survey
13
3.1.1 Level-I Questionnaire Survey

3.1.2 Level-II Questionnaire Survey
13
17
Water consumption pattern
18
3.2.1 General trends of water consumption and potential

for recycling
3.2.2 Observations from Study
18
3.2.2.1
3.2.2.2
3.3
Variation of water consumption due to

variation of manufacturing process
Water Balance of various products
18
18
19
Field Study
3.3.1 Selection of drugs and Industries for field study
3.3.2 Results of field study
20
20
4.0 Guideline for Water Consumption for Selected Bulk Drugs
4.1
4.2
4.3
4.4
Unit for water Consumption

Working Day Calculation
Calculation of Process and Utility Water
Rational for proposed limit of maximum water consumption in
selected Bulk Drugs
28
28
28
31
4.4.1 Selection of Bulk Drugs

4.4.2 Guideline for water consumption
31
33
List of Annexures
I
Level-I Questionnaire
37
II
Level-I Responses of Company-wise
39
III
Level-II Questionnaire
55
IV
Response of Level-II Questionnaire Survey
60
Water Balance Sheet
62
VI
Level-I Calculation of Utility Water Company-wise on

Prorata basis
87
Name and Address of Bulk Drug Industries in India (State-wise)
98
List of Tables
2.1
Classification of Bulk Drugs
04
2.2
Production of Bulk Drugs
09
2.3
Production of Bulk drugs in terms of Therapeutic class during

2004-05
10
2.4
Imports of drugs and pharmaceuticals
11
2.5
Exports of drugs and pharmaceuticals
11
2.6
Typical contract manufacturing deals in India
12
3.1
Fifty three therapeutically classes covering 186 drugs
14
3.2
Selected Industries and Drugs for final visit
21
4.1
Calculation of Process and Utility Water
28
List of Figures
2.1
Distribution of Bulk Drug Industries India
07
2.2
Sector Wise distribution of Pharmaceutical Industry in India
09
3.1
Line Chart for production volume
22
3.2
Line Chart for number of Manufacturers
23
3.3
Water Consumption and Wastewater generation pattern in

Bulk Drug Industries
24
3.4
Streams arise from Bulk Drug (Organic Synthetic) Industry
25
3.5
Stream wise BPT in Bulk Drug Industries
26
3.6
A typical fermentation process flow diagram for

manufacturing of Anti Biotic
27
List of Acronyms
API
APCD
APPCB
BDMA
BPT
CHEMEXCIL
CIMS
CMP
CNS
CT
DGCIS
GPCB
EMS
ETP
FICCI
ICMA
IDMA
MPCB
MNC
NPPA
OPPI
OS
SSI
USFDA
Active Pharmaceutical Ingredients

Air Pollution Control Device
Andhra Pradesh Pollution Control Board
Bulk Drug Manufacturing Association
Best Practicable Technology
Basic Chemicals, Pharmaceuticals and Cosmetics Export
Promotion Council
Current Index of Medical Specialists
Contract Manufacturing Process
Central Nervous System
Cooling Tower
Directorate General Commercial Intelligence Et Statistics
Gujarat Pollution Control Board
Environmental Management System
Effluent Treatment Plant
Federation of Indian Chamber of Commerce &t Industry
Indian Chemical Manufacturers Association
Indian Drug Manufacturing Association
Maharashtra Pollution Control Board

Multi National Company
National Pharmaceutical Pricing Authority
Organization of Pharmaceutical Producers of India
Organised Sector
Small Scale Industry
United States Food and Drug Administration
CHAPTER - 1
1.1
Introduction
National Environment policy - 2006, while addressing the fresh water

resources, also includes actions to "Improve productivity per unit of water
consumed in industrial process, by making the water assessments and water
audits *Mandatory* in identified industries and units".
There is a provision of levy and collection of cess form any person carrying
on any industry on any local authority consuming water under Section 3 of
the Water (Prevention and Control of Pollution) Cess Act, 1977. The
provision also include rebate under Section 7 of the same Act, to encourage
the industries and local authorities, who comply with the following.
(i)
The provisions of Section 25 of the Water (Prevention and Control of

Pollution) Act, 1974 (6 of 1974);
(ii)
The standards laid down by the Central Government under the
Environment (Protection) Act, 1986 (29 of 1986); and
(iii) Consume water within the maximum quantity as prescribed in behalf
of any industry or local authority.
The maximum prescribed quantity of water has already been specified in

schedule with respect to Rule 6 of the Water (Prevention and Control of
Pollution) Cess Rules, 1978 for 23 category of industries. However, bulk drug
manufacturing units are not covered under this schedule. The Central
Pollution Control Board has therefore carried out a study the complete
involvement of water and its consumption for various utilities in the Bulk
drugs manufacturing industry The reports cover details of this study and
guidelines formulated for water consumption in this sector.
1.2 Objective
The objectives of the study are as below:

(a)
(b)
Specify maximum water consumption for each bulk drug or a group of

bulk drug.
Purpose for which water is consumed shall be specified in following
manner

Utilities- cooling and boiler feeds etc

Domestic purposes
Processes whereby water gets polluted and the pollutants are
easily biodegradable; non toxic, both non-toxic and easily bio
degradable
(c)
Processes whereby water gets polluted and the pollutants are

not easily biodegradable; toxic, both toxic and not easily bio
degradable
Identification of wastewater streams for recycling /reuse after

suitable engineering innovation.
1.3 Methodology

Preparation of an exhaustive list of names, addresses and other

information of the bulk drug manufacturers in the country from the
available data of the bulk-drugs manufactures and from the relevant
authorities.
Preparation of level - I questionnaire and circulation to each of the

listed manufacturer. The questionnaire included name, address,
phone number, fax number of the industry, data of bulk-drug
produced, drug intermediates, consumption of water in process and
utilities and other relevant information.
Classification of the types of drugs, number of manufacturers and

quantum of drugs produced.
Number of industries producing same type of drugs and consumption

of water for process and utilities.
Classification of the therapeutic class of each drug from the available

authentic sources. For example, antibiotics, anti histamine, anti
cancer, anti T. B., anti diabetic etc.
Data collection/review and preparation of a second level of

questionnaire (Level II) for detailed information to arrive at a water
balance, mass balance as possible and derived consumption of water
for process and utilised for each drug.
Field visits to 6 selected industries in the country to study the

manufacturing process, water balance and possibility of water reuse/
recycle to optimise the water consumption.
Analysis of the combined data of Level - I, Level - II, field visits and
derivation of optimum water consumption limits for each selected
drug.
The sources contacted for collecting information on the bulk-drug

manufactures are the concerned government departments and accredited
trade associations of the bulk-drug manufacturers. This process also
included organisation of a series of meetings with the associations such as
Indian Drug Manufacturing Association (IDMA), Bulk Drug Manufacturing
Association (BDMA), Indian Chemical Manufacturers Association (ICMA),
Organization of Pharmaceutical Producers of India (OPPI), consultant like
ORG-MARG and authorities such as Department of Chemicals and
Petrochemicals, Govt. of India, National Pharmaceutical Pricing Authority
(NPPA), Maharashtra Pollution Control Board (MPCB), Gujarat Pollution
Control Board (GPCB), Andhra Pradesh Pollution Control Board (APPCB) and
Basic chemicals, Pharmaceuticals and Cosmetics Export Promotion
Councit(CHEMEXIL).
The findings of the report were presented in the peer and core meeting for
finalisation of water consumption limits. The limits finally suggested and
may used by State Pollution Control Boards as guidelines.
CHAPTER - 2
STATUS OF BULK DRUG SECTOR
2.1
Pharmaceutical Sector in India

The Pharmaceutical industry is presently meeting almost 95% of country's
pharmaceutical needs. The Indian pharma industry is currently valued at
approximately $8.0 billion. Globally, the Indian industry ranks 4th in terms
of volumes and 13th in terms of value. Indian pharmaceuticals industry has
over 20,000 units. Of these 260 units are in organized sector, while others
exist in small-scale sector.
The market share of Indian industries has increased steadily from 67.97% in
the year 1999 to 72.77% in year 2003.
2.2 Classification of Bulk Drugs

The Indian pharmaceutical industry can be divided into bulk drug segment
and formulations. The drugs can be classified by their therapeutic use in
man and animals as also by their Chemical Structures (like sulfa drugs).
However, the classification based on therapeutic use is generally accepted.
The classification system adopted in Current Index of Medical Specialities
(CIMS), 2003 has been used as a reference for the purpose of this report.
The Bulk Drugs are classified in 19 Main classes based on the Anatomical
system they have an effect on 77 Subclasses based on their Therapeutic use.
However during the study time only 58 therapeutic class have been covered.
Table 2.1 is summarised below.
Table 2.1: Classification of Bulk Drugs.
S. No.
Anatomical System
1.
Alimentary System
2.
Cardiovascular System
Therapeutic Class
Hyperacidity, Ulcers
Sedatives, Antispasmodics, Prokinetics
Laxatives, Purgatives, Lubricants
Drugs acting on Colon and Rectum
Antidiarroheals
Hepato-Biliary Drugs
Anti hypertensives
Antianginals and Coronary Vasodilators
Antiarrythmics
Peripheral Vasodilators
Vasoconstrictors
Anticoagulants, Antithrombotics,
S. No.
3.
4.
5.
6.
7.
8.
9.
10.
Anatomical System
Therapeutic Class
Fibrinolytics
Haemostatics
Inotropic agents
Diuretics
Lipid Lowering Agents
Other Cardiovascular Drugs
Central Nervous System Hypnotics
Anti psychotics
Anxiolytics
Antidepressants
Anti emetics
Anticonvulsants
Rigidity Et Tremor Controllers
Cerebral Activators
Pains, Fever
Analgesics 8t Antipyretics
Anti migraine Drugs
Musculoskeletal System
Anti rheumatoid Drugs
Muscle Relaxants
Anti gout drugs
Rubefacients, Topica Analgesics
Endocrine Disorders
Gonadal Hormones 8t Related Drugs
Corticosteroids
Tropic hormones
Thyroid Et Anti thyroid drugs
Diabetes
Insulins
Oral Anti diabetics Et Related Drugs
Drugs for Hypoglycaemia
Fertility
and Ovulation Inducers
Antifertility Agents
Oral Contraceptives
Spermicidal. Drugs
Genito Urinary System
Diuretics
Urinary Antiseptics I:t Alkalisers
Urogenitals
Drugs for Vaginal Et Urethral Conditions
Drugs action on Uterus
Impotency Drugs
Infections and
Anti bacterials
Infestations
Anti TB
Anti leprotics
Anti fungals
Anti amoebic and Anti protozoa
Anti malarial
Anthelmintics
Anti virals
Vaccines, Sera &t Immunisers
S. No.
11.
12.
13.
14.
15.
16.
17.
18.
19.
Anatomical System
Respiratory System
Therapeutic Class
Anti asthmatics
Antitussives, Expectorants,
Decongestants
Nutrition Et Metabolism Tonics and Appetite stimulants
Other Nutritional Suppliments
Vitamins
Electrolytes
Antiobesity Drugs
Allergic Disorders
Antiallergic
Ear, Nose Et Oro har nx Topical Nasopharyngeal Medications
Eye
Ocular Antiinfectives
Ocular Antiinflammatories
Drugs for Glaucoma
Mydriatics, C clo le ics Et Miotics
Skin
Topial Antibacterials &t Antifungals
Psoriasis, Seborrhoea, Ichthyosis
Topica Steroid Preparations
Pigmentation disorders
Miscellaneous Skin Preparations
Neoplastic Disorders
Antineo lastic agents
Immunosuppresants
Immunosuppresants
Surgicals
Anaesthetics
Neuromuscular Blockers
Infusion Fluids, Plasma Expanders
2.3 Segmentation of Pharmaceutical Industry:

Pharmaceutical manufacturing sector can be divided in four distinct
segments depending on the production and manufacturing activities carried
out as below:
n
Bulk Drugs: This sector manufactures Bulk Organics and Inorganic

medicinal chemicals and their derivatives. The sector is composed of
facilities that manufacture products of natural origin, hormonal
products, basic vitamins as well as those that isolate active medicinal
ingredients from botanical drugs and herbs.
Formulations: This sector includes facilities that process the Active

Pharmaceutical Ingredients (APIs) into pharmaceutical preparations for
human and veterinary use. Finished products are sold in various dosage
forms including tablets, capsules, ointments, solutions, suspensions
and powders.
In Vivo and In Vitro Diagnostic Substances: This sector includes

manufacturing of chemical, biological and radioactive substances used
in diagnosing and monitoring health.
Biological Products: This sector includes production of bacterial and

virus vaccines, serums, plasma and other blood derivatives for human
and veterinary use other than in-vivo and in-vitro diagnostic
substances.
2.4 Bulk drug Sector in India

India's bulk drug sector makes up about 6% of the international bulk drug
market. Drug intermediates are used as raw materials for the production of
bulk drugs, which are either sold directly or retained by companies for the
production of formulations. Formulations can be subdivided into generic
drugs and branded or "ethical" drugs, the latter of which are made under
process patent and sold under a separate brand name. Expected short-term
growth for the two types of drugs 20% for bulk drugs and 15% for
formulations. Fig. 2.1 represents distribution of Bulk Drug industries in
India.
Fig. 2.1 Distribution of Bulk Drug Industries in India
It can be seen from the figure above that Andhra Pradesh, Maharashtra and
Gujarat have high concentration of bulk drug industries. These three states
were therefore taken up for studuing the profile of industries and the drugs
manufactured.
Bulk drug industries can be segmented in three distinct categories based on

their scale of production, as:
Organised Sector (OS): Typically consists of multinational organizations
having a number of manufacturing sites spread across the country.
Organised sector is mainly into production of export-oriented drugs.
These industries generally have year-long campaigns for some specified
drugs. As the capital investment capacity of this sector is much higher
than other segments, these facilities can afford dedicating a certain
number of reactors only for a specific product under campaign. This
makes running the process continuously possible.
As one intermediate in the synthetic process is formed, it moves to the

next reactor in line for further processing while the previous reactor can
be readied for starting a fresh batch. Thus during the production
campaign the entire manufacturing unit is processing some synthetic
stage of the same final product.
Continuous operation of processes helps in increasing the production
volume and forming a niche market sector thus also making the
production cost effective. Also, having the whole manufacturing plant
dedicated to a single product makes it easier to install pollution control,
treatment and recovery facilities.
Medium Scale Sector: This sector consists of industries whose operation
scale is smaller than the organized sector but who still have more than
one manufacturing sites. Production is taken up on a batch scale and a
number of production campaigns can be undertaken in a year for various
drugs as per the market demand. This sector not only manufactures
drugs for domestic marker specifically but also manufactures exportoriented drugs as per market demand.
Small Scale Sector: This sector typically comprises of units with only
one manufacturing site. This sector often makes those drugs that are
specifically reserved for small scale sector. Some units in this category
are into manufacturing of certain intermediates which are used in Bulk
Drugs manufactured by medium and organised sector and some others
are into carrying out the entire synthesis process of Bulk Drugs except
formulation, which is done by Organised or Medium Scale sector and
marketed under their brand name.
Production campaigns of these industries fluctuate with the market
demand. These units carry out operations on batch scale and
manufacturing facilities are generally not dedicated to a specific
product. As the investment capacity of these units is much lesser than
the organized or medium scale sector, there is a general lack of
pollution abatement and control measures available at manufacturing

sites of these industries.
Fig. 2.2 present sector-wise of pharmaceutical units across Andhra
Pradesh, Maharashtra and Gujarat.
250
Units O.S. flMED n S.S.I.

n Total..............
200
150
z loo
we
0f
Fig. 2.2: Sector-wise distribution of Pharmaceutical Industry in India
It can be seen from Fig. 2.2 that Andhra Pradesh has the maximum number
of Bulk Drug units in India. Andhra Pradesh also has more number of
industries in Organised and Medium Scale Sector compared to Maharashtra
and Gujarat; on the other hand Bulk drug sector in Maharashtra and Gujarat
mainly comprises of small scale industries with Maharashtra having the
maximum number of small scale bulk drug manufacturing industries .
2.4.1 Production
The production of bulk-drugs during the five year period 2000 to 2005 is
shown in Table 2.2.
Table 2.2 Production of bulk drugs
Year
2000-01
2001-02
2002-03
2003-04
Production
(thousand
tonnes)
18.73
19.86
22.13
22.14
2004-05
18.19
Source: Annual Report (2001-2002 & 2005-2006), Department of Chemicals and

Petrochemicals, Ministry of Chemicals and Fertilisers
The production of bulk-drugs in terms of their therapeutic class is given

table 2.3.The majority of the bulk-drugs produced are Anti- biotics
constituting 33.76% of the total production. Analgesics and Antipyretics
account for nearly 25% of the total production. Anti Dysentery and Vitamins
constitute about 15% of the total bulk-drugs production.
Table 2.3: Production of bulk drugs in terms of therapeutic
class during 2004-05
S. No.
Therapeutic Class
Production
(in tonnes)
Percentage of
Total Production
59.794
0.32
Anaesthetics
Analgesics Et Antipyretics
4476.302
24.6
Anti Asthmatics
438.961
2.41
Antibiotics
6141.571
33.76
Anti Diabetics
47.4
0.26
Anti Dysentery Drugs
2770.444
15.23
Anti Filarials
Anti Helmentics
52.525
0.28
Anti Histamines
51.679
0.28
10
Anti Leprotics
11
Anti Malarials
230.367
1.26
12
Anti T. B. Drugs
1147.364
6.30
13
Cardiovascular Drugs
4.863
0.02
14
CNS Stimulants
14.510
0.08
15
Corticosteroids
5.071
0.02
16
Diuretics
23.342
0.12
17
Gastro Intestinal
695.524
3.82
18
Other Anti Bacterials
524.272
2.88
19
Sulpha Drugs
0.715
20
Tranquilizers Et Sedatives
15.154
0.08
21
Vitamins
1490.545
8.19
18190.403
100%
Total
Source: Annual Report (2005-2006), Department of Chemicals and Petrochemicals, Ministry

of Chemicals and Fertilisers
10
2.5 Findings of Industry Survey on Bulk Drug Manufacturers
Industry survey on Pharmaceuticals manufactured in India has shows a

production of 400 Bulk drugs and nearly 60,000 finished medicines
(formulations) in the country. However, it is observed that a numbers of
drugs are being produced on contract manufacturing and campaign basis.
2.6 Import-Export Trends in Indian Pharmaceutical Sector
2.6.1 Import
The import of drugs and pharmaceuticals is given in Table 2.4. The import
of the drugs includes formulations thereby inflating the figures for bulkdrugs. The country has large Contract Manufacturing Process (CMP) units.
Such units import the raw materials i.e. bulk-drugs and process it to an
intermediate form or a finished form. The import of drugs and
pharmaceuticals has increased by about 17% from 1999-00 to 2003-04.
Table 2.4 Import of Drugs and Pharmaceuticals
Year
1999-00
2000-01
2001-02
2002-03
2003-04
Import
(000'Tonnes)
1.237
1.756
2.565
1.5512
1.447
Source: Directorate General Commercial Intelligence and Statistics, Kolkata
2.6.2 Export
The export of drugs and pharmaceuticals is given in Table 2.5. The export
quantity includes the formulations and finished products of the CMP firms.
But the export of formulation is far outweighed by the export of bulk-drugs
intermediates and finished products manufactured from the local raw
materials. The exports have grown by more than 325% from 1999-00 to
2003-04.
Table 2.5 Export of Drugs and Pharmaceuticals
Year
Exports (000'Tonnes)
1999-00 2000-01 2001-02 2002-03
47.21
83.108
Source: DGCIFtS, Kolkata
11
86.112
117.191
2003-04
200.774
Z.7 Current trends in Indian Pharmaceutical Sector

Many global pharmaceutical majors are outsourcing manufacturing from
Indian companies. For the same reasons, many Indian pharma companies
are going for compliance with International regulatory agencies like USFDA
for there manufacturing facilities. Top Multi National Company (MNCs) like
Pfizer, Merck, GSK, Aventis, Novartis etc. are largely depending on Indian
companies for many of their APIs and intermediates. The Boston Consulting
Group estimated that the contract manufacturing market for global
companies in India would touch $900 million by 2010. In the year 2004,
Indian companies bagged manufacturing contracts worth $75mi(lion.Table
2.6 that shows certain contract manufacturing deals of MNCs with Indian
companies
Table 2.6
Typical Contract Manufacturing Deals in India
Indian Company
Lupin Laboratories
Multinational
Product
Fujisawa
Cefixime
Apotex
Cefuroxime Axetil,
Lisinopril
Allergan
Bulk and Formulations
Advanced Medical Optics
Eye Products
Wockhardt
Lvax
Nizatidine
IPCA Labs
Merck
Bulk Drugs
Tillomed
Atenolol
Orchid Chemicals
and Pharmaceuticals
Apotex
Cephalosporin and
other injectables
Kopran
Synpac Pharmaceuticals
Penicillin-G Bulk Drug
Cadila Healthcare
Altana Pharma
Intermediates for
Pantoprazole
Boehringer Ingelheim
Gastrointestinal and
CVS products
Nicholas Piramal
The import/export data and the present growth rate of the Indian
Pharmaceutical sector are evidences of a significant impact of this sector on
the country's economy.
12
CHAPTER - 3
RESULTS AND DISCUSSIONS
3.1 Questionnaire Survey
The questionnaire survey was accomplished in two steps i.e. Level-I and
Level- I I .
3.1 .1 Level-I Questionnaire Survey
Level-I survey questionnaire was designed to get preliminary information on
product, water use in process and utility, manufacturing process of bulk
drugs. The questionnaire is depicted in Annexure-I. 113 industries out of
403 manufacturers responded to level-I questionnaire. 113 industries have
covered 259 drugs in 58 therapeutics classes. The limitation of level-I
questionnaire survey that utility water consumption drug-wise in a multiple
drugs producing company was not furnished, as no dedicated water meter
for process and utilities was installed by any industry. The second limitation
is that water consumption data was furnished in unit m 3 /day, and product
as MT/yr. However, no data was furnished on number of working days. The
data furnished by the industry with respect to drugs are in Annexure -II.
Close examination to data given following informationIn some cases, with the increase of production there is increase of
water consumption at process with respect to some drug. But in some
cases, such trend is not there. Infact, there is no distinct trend
between production and process water consumption.

It is also understood unit-wise MT/yr with respect to production and

m3/ton of product with respect to water consumption can be
considered for comparison.
It is also observed that there is two distinct production processes one

is synthetic route and other one is fermentation process.
Fermentation process consumes more process water in compare to
synthetic route.
Statistic analysis is of production data indicates that 70% data falls

below 160 MT/yr out of 186 drugs of various therapeutic classes. It is
considered that Beyond 160 MT/yr shall be considered higher
production.
The statistical analysis is also reveals that 70% data falls below
number 5 with respect to number of manufacturing unit producing
13
the some drug of various therapeutic classes. It is also considered

that Beyond 5 shall be considered as high.

This has been summarized in Table 3.1 and presented in Fig 3.1 and
3.2.
This statistical analysis help us to grouping the industries as follows:

Group-I: High production - Higher Number of Manufacturers
Therapeutic class having production volume greater than 160
tons/year and number of manufacturers greater than equal to 5 in
each class are classified as Group-I. These are Analgesics, Anti
Asthmatics, Antibiotics, Anti fungal, Anti helmentics, Anti T.B.,
Vitamins, Anti inflammatory, Gastro intestinal etc.
Group-H: High production - Lower Number of Manufacturers
Therapeutic class having production volume greater than 160
tons/year and number of manufacturers less than or equal to 5
classified in Group-II. These are Anti malaria, Antibiotics
(fermentation), Antiseptic.
Group-III: Low production - Higher Number of Manufacturers
Therapeutic class having production less than 160 tons/year but
number of manufacturers is more than equal to 5. These are Anti
histamines, Anti hyper sensitive, Anti emetic, Anti ulcer.
Group-IV: Low production - Lower Number of Manufacturers
Therapeutic class of drugs such as CNS stimulants, Anti Leprotics etc.
is manufactured by a small number of factories. It is a specialized
Job.
This groupification helps to lead to level-II survey for more detailed
investigation.
Table 3.1: Fifty Three Therapeutic classes covering 186 Drugs
No.
Therapeutic Class
Number
of Drugs
Number of
Manufacturers
Actual
Production
1.
Anaesthetics
2.
Analgescis
10
19
5692.65
3.
Anti-Asthamatics
301.003
19
40
3368.27
4. [And-Bacterial
14
2.00
No.
Therapeutic Class
Number
of Drugs
Number of
Manufacturers
Actual
Production
5.
Anti- Biotics (Synthetic)
17
34
1722.16
6.
Anti- Biotics
(Fermentation)
2148.00
7.
Anti-Diabetics
14
249.106
8.
Anti-Dysentry
1774.15
9.
Anti-Fungal
10
335.952
Anti-Helmentics
10
13
196.624
11. Anti-Histamines
13
88.85
12. Anti-Hypertensive
13
20
98.32
13.
Anti-Leprotics
50.00
14.
Anti-Malarial
664.00
15.
Anti-T.B.
978.16
16.
Cardiovascular
165.63
17.
CNS Stimulants
110.00
18.
Corticosteriods
5.70
19.
Diuretics
10
159.56
20.
Sulpha drugs
8.543
21.
Tranquilizers and
Sedatives
19.90
22.
Vitamins
935.365
23.
Androgen
0.09
24.
Anti-amebic
4.18
25.
Anti-Antrogen
0.91
26.
Anti-coccidial agent
48.44
27.
Anti-convulsant
6.173
28.
Anti-depressant
41.3
29.
Anti-emetic
73.21
30.
Anti-Filarial
70.00
31.
AntiHyperlipoprotienmic
106.60
32.
Anti-Hyperlipidaemia
0.36
10.
15
No.
Therapeutic Class
Number
of Drugs
Number of
Manufacturers
Actual
Production
33.
Anti-Infective
19.17
34.
Anti-inflammatory
265.51
35.
Anti-manic
3.864
36.
Anti-septic
162.00
37. Anti-Spasmodic
0.90
38.
Anti-Thrombotic
6.00
39.
Anxiolyte
3.50
40.
Anti-obesitics
0.927
41.
Anti-planet Aggregation
0.845
42.
Anti-ulcer
11
71.24
43.
Anti-viral
66.08
44.
Calcium replenisher
0.23
45.
Cathatic
1.88
46.
Expectorant
16.8
47.
Gastro Prokinetic
0.207
48.
Gastro instatinals
1542.003
49.
Hematinic
24.40
50.
Hemorheologic Agent
37.493
51.
Hemostatic
0.60
52.
NSAID
6.557
53.
Tocolytic
0.90
186
297
Total
Average Actual production per

Therapeutic class
21656.31
408.6096604
Standard Deviation

Skewness
988.4395994
Percentile (for the value 160 and 5) .
160.003104 69.58 percentile

5.0012
67.31 percentile
_
_
3.792028486
> 69.58 percentile values of 53 data are below value 160.

> 67.31 percentile values of 53 data are below 5.
'Eu
Classification of Drugs:
High Production is anything more than or equal to 160 Tonnes/year.
High Manufacturers is any class having more than or equal to 5 companies
producing it.
3.1.2 Level-II Questionnaire Survey
Selection of industries for level-II is the out come of level-I. From groups I,
II, and III, two drugs are selected from each therapeutic class on the parts
of first and second highest production volume and first and second highest
number of manufacturers. In case of Group-4, following seven drugs are
selected, having relatively higher production volume and higher water
consumption. The drugs are :
Therapeutic Class
Drugs
Expectorant
Anti-depresant
Cathatic
CNS stimulants
CNS stimulants
Sulpha drugs
Anti viral
-
-
-
-
-
-
-
Brohexane, HCl
Fluoxine
Bisacodyl
Caffine
Theobromine
Sulphamoxole
Acyclovir
In the light of above, 53 drugs covered in 27 therapeutic classes were

selected for level-II questionnaire:
Group
Group I
GroupII
Group III
Group IV
Others
Selected for
Level-11 Survey
32
5
9
7
53
5
Level-1 Study
100
5
35
46
186
67
Therapeutic
class
14
3
4
6
27
Not known
Level-II questionnaire (Annexure-Ill) was circulated to 79 companies

manufacturing these 58 drugs. Following information was requested:

Name of the drugs

Production volume ton/year
Drug-wise process water and utility water consumed in m 3 /ton drugwise
17
Total water consumed on actual basis in m 3 /ton at each product

Water balance
Mass balance
Number of working days
Data for 34 drugs are received out of 58 drugs requested, covering 21

therapeutic classes out of 27 classes. Annexure-IV showing summarized of
data receipt, therapeutic class -wise.
3.2 Water consumption Pattern
3.2.1 General trends of water consumption and potential for Recycling
Water use pattern in bulk drug industries is depicted in general term in

figure 3.3. This indicates that in general utilities, services and potable
water source generally consumes water for non-process purposes and as
such generates low strength waste water with respect to pollution
potential. A general trend of characteristic of waste water is given in Figure
3.4. This indicates that if the process water is segregated and treated
separately, the combined waste water from other streams can be treated
and reuse for other purposes. Stream-wise treatment scheme is given in
Figure 3.5. If such system is applied, there is a chance of reuse and
recycling of waste water from bulk drug industries.
3.2.2 Observations from study
3.2.2.1 Variation of water consumption due to variation of manufacturing
process
Most drugs are manufactured through two processes:

i)
ii)
Fermentation
Organic Synthesis
Fermentation
A typical process flow diagram for Antibiotics is depicted in Figure 3.6.

Water required in the fermentation tank, cleaning/washing of the
fermentation tank after each batch of the fermentation growth is taken
out. The water is filtered. Filtrate goes to the drain. Water is needed in
suspension tank, crystallizer.
Once a process is standardized the water requirement is more or less
constant to produce a fixed quantity of anti-biotic. Basic design of
fermentation process has not changed over the years.
18
Requirement of raw water and D. M. water for the production of 1.0 kg of

streptomycin/Amphotericin.
Streptomycin
Type of water
Fermentation
Extraction
Lits/kg
Lits/kg
For
preparation
Total
Lits/kg
of D. M.
Water Lits/kg
Raw water
D.M. Water
Total
Amphotericin B
Raw water
D.M. Water
Total
40
850
315
175
1068
315
1383
360
215
600
300
192
1152
515
1667
Results indicate variation in fermentation process in above two cases with

respect to water consumption is 10%.
Organic Synthesis / Chemical Synthesis
Drugs other than antibiotics are mostly made by the synthesizing a mother
organic molecule of a drug. Synthesis process varies from drugs to drug.
Unlike fermentation, water requirement varies significantly from one drug
to other. Since synthetic process varies from drug to drug. When even
within the same drugs there are variations of process. The process water
requirement to produce drug by synthesis process cannot be standardized.
Data furnished by the manufacturers are therefore relied upon.
3.2.2.2 Water Balance of various products
Water balance for various products is summarized in Annexure-V. Close
analysis to this water balance reveals the following facts:

Water consumption in fermentation routes is higher with respect to

synthetic route in case of antibiotic therapeutic class.
There is a significant variation even with in the same product.
An attempt is made to compare the ratio between process water with

respect to total water consumption. The results are stated below:
o
The ratio of single product is less than 0.1 except vitamins,

paracetamol.
With respect to bi product, the ratio is more than 0.1 but mostly
around 0.4.
[m
With little variations the multi-products shown the same trend

of bi -product i.e. 0.4
This indicates, in a single product industry the water consumption in utility

is higher in proportion than that of bi -product and multi product industries.
Vitamin consumes more process water. Higher consumption in process water
in case of paracetamol worth to be studied.
3.3
Field study
3.3.1 Selection of drugs and industries for field study
The rational for selection of drugs and industries for field study are as
follows:

All the replied drugs were classified into their respective Therapeutic
class. All the replied 34 drugs falls under 21 therapeutic classes.
From each therapeutic class, a drug was selected which was having the
highest total water consumption in a year. So 21 drugs were selected
from 21 therapeutic classes.
Out of 21 drugs, nine was selected on the basis of significant water

consumption.
The industry was chosen on the basis of its response to questionnaire,

reliability of data and credibility and number of selected drugs covered
by the industry. The results are summarized in Table 3.2.
3.3.2 Results of Field Study
It is observed in each cases, there are ample potential to reduce the water
consumption. Some of the industries already have attempted to reduce the
water consumption by recycling and reuse after renovation of wastewater.
All the industries have good house keeping practices and efficient effluent
treatment plant.
One example of water conservation practices are stated below:

Cooling water reduction by installing RO unit and recycling this

water.
Reuse of treated wastewater for gardening
Plan to reuse cooling water blow down and treated wastewater for
toilets flushing
Wastewater from formulations units, to be used for gardening, floor

washing etc.
IM
Table 3.2 : Selected Industries and Drugs for final visit

Sr.
No.
Name of
Therapeutic
Class
Name of Drug
Group
Campo
-nies
which
replied
for
level-11
Volume of Process
Production water
m 3 /ton
(t/yr)
Utility Total
water water
m 3 /ton m 3 /ton
Process
water for
the vol. of
production
1.
Anti-Bacterials Ciprofloxacin
U24
540.00
38.83
697.10
735.93
397402.20
2.
Vitamins
Vitamin C
U91
300.00
248.00
138.00
386.00
115800.00
3.
Anti-Dysentry
Tinidazole
U1
660.00
6.50
120.15
126.65
83589.00
4.
Anti- Biotics
(syn)
Cephatexin
U57
336.00
12.27
238.50
248.77
83586.72
5.
GastroIntestinals
Ranitidine HCl
U24
360.00
37.00
193.00
230.00
82800.00
6.
Anti-T.B.
Etham butol
U15
60.00
800.00
168.90
968.90
58134.00
7.
Anti-Diabetics
Chlorpropamide
U55
96.00
309.02
136.00
445.02
42721.92
8.
AntiBiotics(Fer)
Pencillin G
II
U90
1512.00
9.
AntiHistamines
Pheneramine
Maleate
III
U11
48.87
21
294.40 7123.00 7417.40 11215108.80
14.69
280.00
294.69
14400.03
.O
i
I
2,
IQ
C
O
V
C.)
+.
a
L-
12
L
V
4)
C
J
on
U-
(aeaA/sauuol) uo!lonPOJd ien;od
22
N
L
L
.1J
N
d
N
co
a)
4
0
d
Q.
N
12
a)
I-
F-
.r_U
a,C
J
CD
U-
64w WON
23
--------------- ------
wa
I I
y
'O
on
1
1
'
a
------------- ----
O
A
-i
C
L-
rt
a
c
0
^^
.b
I-
c^
Q)
'
W
JD
L-
a,
47
a.+
----I
1-
------- ------
1i
Iv
fi
a
E
u
GJ
D+
'
'
LL
M
1DJ1
aA
W
----------^
V ^3 0
1.
CD
E
O
O
U)
O
A
U
L
C
N
U
C
O
O) O
Co
O
CE
O
iO
00
to
Wo
it
on
I
-
on
L
E
0I-.
a,
. L-
fe
N
E
te
aW
t
CD
I
25
O
0
O_
a)
LL
>
W
'-p
J
J
_J
>
Q
u
W
0
V

il
OC W
I-
'
O W
W O
J
Q
W_
O Q
ZQ u
OC
O
LU
u
uO
0
m
C)
^ m
Wu
oWG
U_
Z
Lii
>
O
N
W
u O
GG
=
u
u_
_j O
cC
>
v^
on
L-
dm
,^
tom.*!
6/1
C
I0
E.
b
a,
L
Lfl
m
O
0
0
26
Di)
LL
WC
0E
ata
*'
c =55
0
C
9-
aw
"-
I- E
W L
LL
izE
on
C
.
CtC
IS
+'

L.
LA
L-L
= L
c
C
G
N
N
N
CD
I-
0.
CO
01
C l
eI
Y^
U^
IS U
E
N
LL
rC
UO
N
f5
U- m
C
CmO
Z'SC
C7
'S
=J
.
IS IL.
_
E
a)
27
2
L
M E
^Ld
U-
400 ff.
ai
,w=
0.
I-
Q
(I. U)
1OM
on
CHAPTER - 4
GUIDELINES FOR WATER CONSUMPTION FOR SELECTED BULK DRUGS
4.1 Unit for water consumption
In order to arrive water consumption for each bulk drug, the data provided
in the m 3 /day shall not be considered as unit. Since the drugs produced by
batch operation rather than continuous, a wide variation is expected on
day-to-day basis. It is, therefore, necessary to convert m 3 /day water
consumption to m 3 /ton of product. Industries provided the yearly
production figure in ton/year and water consumption figure on m 3 /day
basis. If the ton/year can be converted to ton/day, the figure of water
consumption on process can be reduced to m3/ton, provided the data on
working days are available.
4.2 Working days calculation
Twenty-eight industries have submitted number of working days.
Arithmetical mean of working days is 345.11. Hence, average numbers of
working days adopted are 345 days.
4.3 Calculation of Process and Utility Water
In order to understand, the calculation of process and utility water
consumption on m 3 /ton basis, an example has been cited in Table 4.1 for a
particular industry. This table reveals name of the products, actual
production in MT/year and process water consumption (m 3 /day) in column
2,3,4 for a particular industry. Column 5 and 6 that is the figure of process
water and utility water in m 3 /ton is computed. The premises of calculation
is stated below:
Table 4.1 : Calculation of Process and Utility water
SI.
No
1
2
3
4
5
6
7
8
Name of Product
Ibuprofen
Ciprofloxacin
Ranitidine
Doxazocin
Amoldipine
Carvidiol
Celecoxib
Cetrizi ne
Actual
Production
(MT/year)
900.00
444.00
600.00
1.20
1.80
1.00
5.00
0.20
28
Process
water
m3/day
209.59
91.23
57.53
0.28
1.11
0.68
3.42
0.02
Computed
process
water
m3/Ton
80.34
70.89
32.88
80.50
212.75
234.6
233.98
34.50
Prorata
utility
water
m3/Ton
23.40
11.54
15.60
0.03
0.05
0.03
0.13
0.07
S(.
No
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
a)
Name of Product
Cislactum
Dexomethorphon
Dititiazem
Domeperindone
Enala ril
Enrolflaxacin
Enrolfloxacin/
Intermediate
Famotidine
Flouxetine
Flucanazole
Keterolac
Lansoprazote
Lomefloxacin
Losartan
Naproxen
n-Benzyl
Piperidone
NMCP
NMSM
Norfloxacin
Omer razole
Ondansetron
Panroprazole
Pefloxacin
Setrline
S arfloxacin
Terazocin
Actual
Production
(MTlyear)
Process
water
m3/day
Prorata
utility
water
m3/Ton
0.52
0.65
0.65
0.13
0.19
3.96
1.87
20.00
25.00
25.00
5.00
7.40
152.00
72.00
13.70
17.12
17.12
3.42
0.20
31.23
22.68
Computed
process
water
m3/Ton
236.32
236.25
236.25
235.9
9.3
70.89
108.67
15.00
2.60
1.50
2.40
4.80
5.10
6.50
240.00
30.00
5.34
0.64
1.03
0.20
3.95
1.26
4.45
85.48
20.55
122.82
84.92
236.9
28.75
284.00
85.23
236.20
122.87
236.32
0.039
0.07
0.04
0.06
0.12
0.13
0.17
6.24
0.78
10.00
360.00
78.80
12.00
0.60
1.30
4.00
2.00
8.80
0.60
6.85
147.95
19.43
4.93
0.14
0.85
0.99
1.37
2.41
0.14
23.62
141.78
85.06
141.73
80.50
225.57
85.30
236.30
94.48
80.50
0.26
9.37
2.05
0.31
0.02
0.03
0.10
0.05
0.23
0.02
Computation of process water in m 3 /ton
The data of ibuprofen drug is considered as an example. Actual production

of Ibuprofen is given 900 MT/yr. One year is equivalent to 345 days. Thus
the production 900 MT/year is equivalent 900 MT/345 days. Process water
consumption is 209.59 m 3 /day. Therefore, process water consumption in
m 3 /t.
_
=
209.59
------------- x 345
900
80.34 m 3 /MT
29
m3 /day
-------------MT/day
b)
Prorata calculation
of utility water in m 3/ton
Total production of 34 products in the factory is 3045.6 MT/year

i.e.(P1 + P2 + P3 ----------- P34) =
3045.6 MT/year
Total water consumption for 34 products for utility purpose is 700 m 3 /day
Number of working days
345 days
700X345 m 3 xthy
thy
Total utility water consumes for =

34 products per annum
241500 m 3
Total production of 34 products =
per annum
3045.6 MT
(34 products) of 3045.6 MT

required
241500 m 3 utility water
241500
--------- = 79.29 m 3 utility water
3045.6
Proportional factor
79.29 m 3
--------------- = 0.026
3045.6 MT
Utility for 1 MT Ibuprofen
0.026 X Actual production of

Ibuprofen
0.026 X900
23.4 m 3 (as shown in Table 4. 1)
(34 products) of 1 MT
required
With this computed annexure II is transformed to Annexure-VI
30
4.4 Rational for water consumption in selected bulk drugs

4.4.1 Selection of bulk Drugs
It is realized from the figure of consumption of water with respect to bulk
drugs varies widely among the drugs and also within the drugs. Any attempt
to arrive a single figure is not a practicable proportion, even therapeutic
class wise. Within this backdrop, the best option lies to propose maximum
water consumption drug wise. While examining the data typically, it was
observed that in some cases data was not adequate or data obtained
through questionnaire survey was not up to the satisfaction. In some cases
data also varies from industry to industry producing the same drugs at three
different locations.
In view of above, the criteria adopted for selection of drugs are as follows.
Volume of production
Drugs produced by maximum industries
Maximum coverage of therapeutic class
Availability of water with respect to locations
Level of maintenance of plants, age of plants
Number of unit operation involved
Awareness of the factory regarding conservation of water (reuse/
recycle of wastewater)
Credibility of data supplied
These are illustrated below
Volume of production and numbers of industries manufacturer

As stated in chapter 3 , the statistical analysis has been made to classify
industry with respect to volume of production of bulk drugs and number of
industries producing the drugs. The result of statistical analysis emerged out
with four groups The water consumption figure for such drugs which has
higher volume of production and maximum number of manufacturers given
more stress than lower production and less number of manufacturers.
Maximum coverage of therapeutic class

The attempt was made to cover all most all 58 therapeutic class In such
cases a single drug produced by a particular therapeutic class and the data
obtained through questionnaire survey seems to be adequate, than that
drug is considered.
31
Availability of water with respect to locations
It was observed during survey that the water consumption for a particular
drug by a group of industries having same technology at three different
locations varies. This variation attributed to availability of water at that
location. Under the constrain situation, an industry has adopted various
method to conserve water and optimize the water consumption. Under such
circumstances the lowest figure attained by the industry is considered.
Level of maintenance of plants and age of plants
It is also observed during in in-depth study or on the spot questionnaire

survey that a plant consumes less water, those who has adopted good house
keeping practice and also high level of maintenance. Age factor is also one
of the reason for variation of water consumption. Updating of machinery
with time reduced the water consumption as well as generation of
pollution. Comparison between the two factories for a same drug, the water
consumption figure of the factory adopting good house keeping and
updating machinery is the choice.
Number of unit operations involved
It is understood that when an industry produced a drug from intermediate,

consume less water in comparison to those industries, which produced both
intermediate as well as final products. In such situation the water
consumption figure of later is intermediate plus final product is considered.
Awareness of the factory regarding conservation of water
The industries which have a best environment management practices having

ISO certified i.e. ISO 9000, ISO 14000, approved by a drug control authority
like USFDA and other certified Environment Management System (EMS)
consume water with less variation in compare to other industries. The water
use pattern of such manufacturers is totally controlled, because no
variation in material and water input can be allowed without prior approval
of USFDA. In those cases the water consumption for that industry is
considered.
Credibility of data supplied
The industry, which has a proper EMS , reputation in the market and shown
co-operation during visit as well as in the questionnaire survey, has been
considered for water consumption limit.
32
4.4.2 Guidelines for Water Consumption

Considering the above criteria the maximum water consumption limits for
84 drugs are presented below. The limits for maximum consumption for
selected bulk drugs have been computed based on total water consumption
in process water and utility water. The same has been expressed in m 3 /ton.
Sr.No.
Therapeutic Class / Name of drug
Total water m 3 1 ton

+/- 5 %)
Analgescis
1.
2.
3.
4.
5.
Diclofenac sodium
Ibuprofen
Naproxen
Paracetamol
Pentazocine
6.
Secnidazole
58
50
150
29
352
Anti amebic
239
Anti antrogen
7.
Flutamide
232
Anti asthamatics
8
9.
10.
Ephedrine HCl
Satbutamol
Theo h lline
672
77
175
Anti bacterial
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
Cefachlor
Ce halos orins
Clarithromycin
Ci rofloxacin
Enrofloxacin
Flume uine
Nalidixic
Norfloxacin
Pefloxacin
Sparfloxacin
Sultamicillin Tos llate
Trimethoprim
23.
24.
25.
Amax citlin
Am icillin
Azithromycin
345
361
454
220
74
64
140
127
21
154
51
61
Anti biotics
26
36
131
33
Sr.No.
26.
27.
28.
29.
30.

Ce halexin
Chtoram henicot Palmstate
Erth om cin Stearate
Penicittin
Roxithromycin
Total water m3/ton

+1- 5
45
25
771
520
101
Anti coccidial agent
31.
Satinom cin
240
Anti de ressant
32.
33.
Clomi ramine HCt

Paroxetine HCl
34.
35.
36.
37.
Chlorpropamide
Gl benctamide
Phenformene HCl
Metformin HCt
38.
39.
Metronidazote
Tinidazole
74
280
Anti diabetics
445
280
280
2
Anti d senter
87
127
Anti filarial
40.
41.
Diethyl Carbamazine
Dieth lcarbamazine citrate
4
2
Anti fungal
42.
Ftuconazole
305
Anti helmentics
43.
44.
45.
Atbendazole
Fenbendazote
Mebendazote
73
3 71
115
46.
47.
48.
Anti histamines
Fexof enadine Hydroc hloride
Loratidine
Pheneramine Maleate
347
487
295
49.
Anti h perli idaemia

Atorvastatin Calcium
156
34
Sr.No.
Total water m3/ton

%
1549
)
50.
Lovastatin
51.
52
53.
54.
55.
Anti h
Biso rolol Fumerate
Captopril
Carvedilol
Dilitiazm
Nifedipe
ertensive
427
53
1748
193
4
Anti inflammator
56
204
Celecoxib
Anti le rotics
57
Da Bone
53
Anti malariala
58.
59.
60.
Amodaiguin Base
Chloro uin P
Chloro uin S
42
50
18
Anti T.B.
61.
Ethambutol
62.
63.
Domeperidone
Lansoprazote
149
Anti ulcer
148
474
Cardiovascular
64.
65.
JAtenotot
Xanthinol Nicotinate
143
251
CNS Stimulants
66.
67.
Caffiene
Theobromine
182
329
68.
Corticosteriods
Betamethosane Salts
67
Diuretics
69.
70.
71.
Fru semide
Hydroch toro thiazide
Ome razole
153
185
87 4
35
Sr.No.
Therapeutic Class I Name of drug
Total water m3/ton

%)
Castro Instatinals
72.
Ranitidine HCl
230
Sulpha dru s
73.
74.
134
130
Silver Sul hadiazine

Sul hamoxole
Vitamins
75.
76.
77.
Vitamin A
Vitamin C
Vitamin E
1485
386
87
78.
79.
80.
81.
82.
83.
84.
Others
Dextropropoxyphene HO
Dimetridazole
Amoxycittin Trihydrate
Dextromethorphan
Folic acid
Meto roIotartrate
Triclabendazole
1172
81
95
596
487
257
331
36
ANNEXUREI
Level I Questionnaire
1. Name and address of the Industry, phone, fax no.
2. Specify the name and designation of employee with whomfurther communications are
to be done
3. Name of the individual bulk drugs produced, their production capacity and actual
production er annum
Bulk Drug
Production Capacity
Production
4. Source of Raw Water in the Industry
5. Total water requirement per day in M 3 of the bulk drugs produced
6. Please specify the manufacturing route of the individual bulk drugs

Bulk Drug
Synthetic Fermentation
37
Any Other
(please specify)
ANNEXURE I (Contd.)
WATER CONSUMPTION 8t WASTEWATER GENERATION
Sr.
No.
Project activity
3.
4.
Water consumption
(m3/day)
Total Fresh Recycled
Waste water
generation
(m3lday)
Process
(For each
individual bulk
drug)
Boiler
Cooling Tower
D.M. Plant
regeneration
Chemical
preparation in
ETP
Air Pollution
control
equipment, e.g.
scrubbers
Others Utilities
Services
Floor washings
Equipment
washings
R&D/labs,
Canteen/Adm.
Blocks)
Any other
Gardening
TOTAL
Kindly see the attached filled exemplary questionnaire.

Please attach additional sheets if the present format does not allow space for all
the information.
38
ANNEXURE-II
y Cf
Ln
Ln
fV
cV
CO
++
cV
cV
dc
Ln
O"
^-
nr
y y
ro
r,c- L
oM
r3
CC
O ^V Z C CCCC
Ni
N
,0^Ln00
O '- Co
N
O ^
ri u O
Ln
Q O
a
E
00
O 0 0
Ni
O
NO
N cV -.O .- O
-.O
OO
Ni
OOOOOLnLt
OO
CC
Ni
lV 1- ,
Ni
Ni
Ni
C O
0 0
0 0
O
O o0 O O m- c0 00
O M
O O O
C0
m
.o
.0
M
icjOlÔ^nlÔr^MN
Ur oo p r- in O
Ln M-
.o O1, M
rn in
O L(
M 00
U
4-
'-
0 0 0 0
ZZ+J
:.; J
41
0000U
H
C
0
a
N
a) a) a)
ai
a)
O U U U
U U U U U U U U U U O
a^ a^ v a) v v a v
v a^ a, a^ a^
C C C C
C C C C C
>
N N V11 N (f
E E E E
L L L L
ai
W a)
ai
a, v
C C C C C C C C C C C
In to N Vî+ N to v, N N N N
V N cN U LL Li Li.-
a)
c)
y
bi
'L
0
In
= V
a^
ta
C
c0
C
V
_ QJ
C
E i
U E L O W
^, N L
L L N p
'V
>,
c
>.
^s
E
E
cow
E
N X
L E U N 0 O>
L
p .^ O
.1.d J --+
UN
>,
Q
,^ `F- ra
=^^zzoÊ
dJ N CE
w
N
C
,
N p O M
f^
d 4J
p ^n
cl
^^ 4-1
_.
O U rCF p C
L 4-
i+
a)
L
FDF -ZWZ ^ÔDUdWrUZULLl70Q0000am
0)
O O
o^
Eo
L
L-1
Ni
M O"
Ni
Id'f
t Ln
h'
39
0' N- 00
C'
oo O
I c-.
ANNEXURE-ll (Contd.)
-. t;
a L
N o0 lO
OO
44 0 a
ken
O VM
OOo0MI--c,OC.Ln '-N.
.
r
00
Q QQQQ
000O O
OOO
. N. 00. 6r). 00. O1. tV. tV. O

d' O i n 0 0 0
0. 0. 0. 0. 0. 0. 1,O.
O r- M o0
0 0 0 0 0 0 0 0
00. 00. 00.
O N Ln N i n M
c^ c^
a ^^
Q O
a ^..
O
Ln O O B O O
O O M
Ô O O d
O O O O O
O O O 0000 0'. O O O 0
I^ O
O O O N
06
N
Ô N
O O Ln ^- Ln to N.
O O CD
O O O
N
- M
O
L
o.
.O
O ^
0000000000
00
0000
N N N N N N N N N N O N N a) N N v N N a) N
a-+
I .
a-+
a-
L C L L L t' L L L C L
.1.
.II .
.i
.I
I.
a-
I-
C C C C C C C C C C C C C C C C
L.
L t
4J
-!
4-
C C C C
a)
E c
v v c
x u
O rt3 'i ~ N r0
L^
C
(OZ
L L
c^C
yJ
^C
i( L
O. <
X (000(0 0u
>
u .0
C_
V
v
ai
(/) -0
4-+
V^1 N
a)
c c
aJ +3
_
v io
^_ r^
I-+
C C_ C C
(^
1^ a) E_
C C C
>
>1 to t% ,1 In V) N to In V 1 (' to In In N In L.L to to to to
a)
N
N N Q)
_ C O [6
(^f
Cl 4-
rt3 c0
C C C
N O >+
c O
l-
U
N
2-5 12 E ^0 S
L .1..^ 4J
O
4-7
-.
t0 O O O O E O N
(im01Zom^â NaauL (Jr >au^- ^D-ZZllacon

Q)
O a
a
Eo
au
Z
D >
L/4
Lt i
-> >>
rn Lfl oN.00v
.p I^ o C^
r r r r- N N
ANNEXURE-II (Contd.)
v uL, ^; v
L a
Oao^

O 000000000
co Co CO 000000 CO
.
.
.
.
.
.
.
.
0 0 0 0 0 0 0 0 0
oo co
.
.
.
.
.
.
.
.
.
0000000
00000000000000
.
CD
000
O O O
o 00000000
O
O O R
Ô
If) N N
N N 00
^
. C)
'O Ô
00
00
O O O 00000 O
O O O
O
O O
N N
O O '.0 '.O
'.0 N
O
O
0 0 0 0 000
O O
O O O
d
10 N '.O '.O cV
'.O
a^rnaâa^rnozrnrnrn
oôâ^rnoZo;0 0
OOrnoô^0
0Z
0L
auo^
a
o
L 1
O^1
V..L
^; u
u u u u u V u u u u
C G
v t-=_c^-=t.=
a^ a) a) aD v ai ai CaD ai
-
u V u u u u u u V
a) v a) a) a aD ai
=..1C-
c c c c c c c c^ c
C-
C C-C
c c
> >.. >-. >.. >^ >a^^
a^^ >> >a>>
N G/'f Vl In In In (/) N N V)
N VI t/'I N N l/1 In l/1 In
N^
O
uv
L
-c N
c c c c c c
>^>
ll
In In V1 N V1 In In
(1)
V ,u v ,U ,u V ,U
aD N ai a, au ai v
..c -C -C -C -C -C -C
O ta co
0 0 a)
ua
ij
O
Q^j
x ><-v m o v
v-
NOO
'Vc 'uC
N v=
t0 N
wc^^^^^^vaQ EQavvuvuva Qaoz^^^^

Qj
6 a
E^y u
41
ANNEXURE-11 (Contd.)
>3v^
Oo
Lfl
r.1
Ln
Ln
L
00
4'
3v00000000000000000000
0o co 00 0o co co 00 00 00 00 00 00 00 00 00 00 00 00 00 00
O 00 Ô A N N O
r
O^ O^ O^
C ^ O^ az az O^ O^ O^ O^ O^ O^ az az Oz O^ Oz N N r- r- N r
.
O L
û^
o
N 0 0 0 0 0 0 0 N N O O
1.O Ô O
O O
O O
O O O O O O O O O O O O O O O O O O O O O O O O O
O O
M ^0 Ô ,O a^
O O N O N
O Ô cs
00
O O
D r- .- Ô ^0 N Ô ^0 1D ^- M N M Ô ^ O O
Z
L
u
O O
u U u u u u u u u u u u u u u u u u u u u u u U U u u U
N N N N v N N N N O O N N N N N N O dJ N N N N N N N N N
LL L L C
C
C L L t L
L L
.
C- - L L
L L
4-I
4-1 4-7
4-+
a--i
C C C
a-+
a-+
a-+
4-+
4-+
4-+
a-)
4-)
4..)
a-+
C C C C C C C C C C C C C C C C C C
to V1 N vi V) t/1 u
a-+
4.i
#.)
4.)
C C C C C C C
to N N N to In N t/1 N to vi Vl In to In to N to N N vi
N
N
_^^ O
O
N
î^ O
N N
O
+^+
O
r0
+O+ u 0
r6
Oj U O
N 2 N
Ô ON 'Ô NC
N lL0
2 U 7_
^^ CN= OO^r0
E
. -o C X
N O +'
O C
O N
^^'
=p O O XO C C
N v- O

>
L (1) N
V
E C C cn
L
pQ
0
cCS L V cp O _
L I L C^ J J J r
2 Z Z O d d d
to
^-
.N
-p
4% ei 4-j E O
O a=^,
O fo
O N .0
0E
U
L
c0
f- C7 U J LL W d O Z
t3
O O
4
Eo
p u
z
in
.p
d
Z
L
^/1
42
L h
Co
ce L
.i ,
Ln
N N
r-
3^
0000
'd0 '0
NN r O
.
Cl
O
t
Ol
NLn00 -00NN
OOO
O
-^ N
Ô
O O O
000 NI O'L O OMO
+-^
00
p c N tt^
N O' M
001 O'. Ln
0000
O000
000000
O
Lfl
N o0 O O N
L N i1' Oì p
- r- r- L1 O
00
-- O'
u U u u u u U U u u u u U u
u U U U U U U U
N N N N N N N N N N N N N N
M i"
u'1 N 00
Is
.
U
(^
L L L
N N t/I N N V1 t!1 V1 N to N t/7 to to
c C C
L L
C L i
L i i
4.I
C= c r_ c r_ r_ r_ C C
4J
L L L
dJ
N N N N N N QJ
L L L L L L O
c c C C C C C C
O O O N to V1 N N V1 to t/I
4 -0
hr)
p
M U
a
V
00
Hnvv`^,
o
-
r0
u a ._
v U C t6
N
X N y
X
E N E O
L p r0
u in
tre
0
0_
a)O
,^ ,i E
O
O tCS O
=_
N
U
C X C
N
U O 1 U O
U _d O_ X C
4
^ N O X m O
O 0
N O i
vi O O O O E O E U E O E
(cl
ZL Liw -1ZZt)ucoo_u
Eo
QU
1,_
00
0,1
O' N O M M
d'
Lfl
1,0
N-
000'. O.--N
Z
O
vi
Mt
N N M M M
43
N:
0 N
<Uvv
Q) h
co
M
3^
U
rn
c 0
ti
O O ,h O N N
V
l0 r
00 Ln
M 00
M O Ln p f1 d' Ln Lf1
^T
00
M. .O. O. r.1. 0'. N. d'.
O
M 1^ I^
O N -1O
. N. ^
a o CD
O LCi Ln
Nff lV
In
In 'O
U u u u u V V
ice+
4J 4 4J 4J
4I. iJ
s t .0
.0
.-- r- r-MOMN
InCD
Lfl
0' M
r M m- Ln 0 I^
000'
M.
0'
.
.
O^ 0. `-.
N^
.
00r cV C)
O0ON1,0
0L
ju
o
a o o o o
N N N Ln 1-
CD
o 0 0 0 CD 0 0
O
t
N-
00
0 0 0 0
f1 '
0 0
oo C) c CD a o 0 0
'o co cV 'O M O O o0 'C
- d' N 00 O,
0^1
- O
,, u
4-..
O O
u u V u u u .u u u u u u U u u u u u u u
4_I ' 4-1 ^
4- . 1-+ 1-1 4-+ 4 Y Z 4
4-)
4J
0)0)0)0)0)0)0)
C
C C
N N N N v O O O N O N O N 41 v N 4) N N N
C C C C C C C
t/7 N M V1 N I/
C .0
C. C .0 .0 -C .0
= t.C.0
C C C C C C C C C C C C C C C C C C C C
VI
N N V1 V1 N (f) 1J1 N V1 N V1 (F) V1 V1 to N v
0)
C
L.
C C N
u
u
m cd
.-
O O
u
Ql O V N rU
X
O
a
N C 0
C 0
L 0
N
(.1 N }r
C O
C
^ C N
X X
COCtI N L
O X u-0
W
L O
O N O N ' m O N
++ rC
x C O O O
C
Xp
4 J
0:
X
J
CO
N
E
^6 O^ N ro
_
m C
N
2 O L
O O L
a. O
E X u N 0 O rC 0 N V N
E ++
'C
0 C C C
N
V Cl in O W W W
O m O w^ d) O
O
co 9_ O rtf O O c0 m
LL L lL Y J J J Z C Z Z Z 00 a. a. J V1 F- d
Eo
00
.o
tel
Ha
CO
CO
Q
Z
>
L-
03^
M
o a ^M o
3v^0 0 .o0 c1
O0000C
00000000
000
0000000
O0
^;
.C)0L000
NOMON
O M
M CO -- O
000
M M r
O 0000
O O O
0 0 0' -1O O
in S O 0
Wn O
^:
OO
N N
to Q
CO
O ^
O
C> Ln CO Ô o0
C'0'0'
O', t
O O o0 M .- O- r- O
I-, r- O O N
-00
O ' O,
- O oO c) N O
O Iv 0' O CO
Ln M
oO
O^!
O
U U U U U
4
a
:ice
Zi:4-)
c c
c c c
u u u
u u u u u L) (J
4-)
:4-.) 4-.) 4.J
ri
r
0)0)0)
a)
a) 0) a) a) a)
> >>
t/1
Vl N to Vl N
4 -I
u u u U u u u u
4-) 4-) 4-) 4J 4-)
4-) 4
0)0)0)0)0)0)0)0)
0) 0) a) a) a) a, 0)
CCCCCCC
Q Q c c c c c c c c
N N N N to L/ t/)
Z Z t/1 N t! N V1 , v to
E
on
C_ O v
4i u
>+ u tJ
p0
i
W
_ N
0 O E .0
L o l^
'^ L X i
'J
O V Q W of
*'
ei
= .-
V 4 -0
O 0
_
Z= N
U p
U
N N t0
O rC
QJ N dJ v-6
n
E C E N 0 X
N 'N C t0 L
o i
Cf0 f0 ^' f0 a O p
[ lC O
U
O
E O V
O
4J O
E
r^
O O O +-+ 4)
O
u ?
N O
LL C^ ^ LL V Z W d
V
N Z V1
0
-0). u- E
O C Z L
O O
O
m
^_ 0
m
Vl F- X
01
O a
Eo
a u
in
I',
o CO
od
M M
Z
V1
00'
o^
M't
45
a^
a_J
E
j,
N O
U)
E RS O V N
i ."
Cl)
m W 2 ZE
>
a V
o^
00
rn
fV
Ll
N.
d-
'0
T-
T-
,a
+^
Oz
00
^0
N-
rn d
0M
r-
r-
fV
i Q
RCD
00000
d O
Ô M O. N O
00
0 0
'0 `V' M Oz Oz d' '0
N N N 00 O^ (V M in
0 0 0. 0 0 0
^.n^n
00
T O M
. .
M
O
N N O^
O M O O
N- V O
O ^
a.,
V >.
V
Q O
in
in
r-1
C C C
O
+:+
V
0 O
O O
C C
O O O
a.:+ .^J
O T O O in .O
M^ O N M M
O T O D O O
N N N N 4J di
L L L L
LL Li
li
V1 V N N N N
V V
E 4-
to to U
4-
4-
_ = l_ L_ L r_ L L L L L
4j ^
E +J
N N N to V^1 LL LL LL to LL L
O O
T Ln
O O .
.
.
++ ++ a=+ 4
V V2 U U U U U 2 2 2 U 22 2 2 2
N N O N N N N N N N N O 4J aJ aJ N N
L
L L L L L
L
O O
in
O O O co in N O O in in O O '0 O
N O Iq : O O O
O in
ic. d O i
T- O T N 1O N O O T- T O O O Nr M O N
V U U U
N ^ ^ .^ 4
V U
4J N N
L
4-.' 4-' 4-'
CCC
t% Vl
T V
E
4i
Ir
L
u
O O
+N+
Z U
C_ E
C J C^ 'U
Z
^ N = C N .^ l' W LU
+^+ O V tCS 'F O
UI)
U U
^L Z d
;uOao
^j
O O
O +- O O .. U
p
O
On
O N
vn
[^ r2
E E+J+-2 >m E v
cCf
i
O
N O N Z m
d
R- N kD J
J Y Z d U
O V
V
a V O N
0(1) c- O E
^L Q Z 00 V 02 u- d Q Z Q V O
Q)
Eo
p U
r-
cV
M O
in
C0
O (T
O %D
'0N-
000'
.-
cHv
0
Ô
O
N-
Q
O
00
a LIJ
00
r-
N
NI
rn
M
00
^ O
Lrf
Ln
H O
N- "t O' N-
I^ Ln d' IQ
- O O^Ô O M
O cV
^j
I.flLfl
O O cV ^t M fV Ln fV cV r- r
In
d'
M 0'
O'
û
O
o
0
rn
0000
00000 0
0 0 0 0 0 0 0 0 Cl 0 0 0 0
oROO
O O O O
,
dooLn
r-- M cV
^r
L['^
Ln
qtrÔO6
O
4-J
N
,,, u
u u u u u u u u u u u u u u u u
0 o
v v v v v v a a v a a v a v a a
00000
0
o
Q
o o o
L L L L L L L L L L L L L L L L
>
V 1 V1
rn
tri
u u u u u u
a v a v v v
L L L L L L
c c c c c c c c C c c c c c c c
V1 N to to t/f to to
V1 V1 V1 Vl v N
c a c c c c
to N Vl N V1 N O O
O
0
E a
^ro
0E
EE
U,
O
U
r^
^t^ri
.c ro
to cV 1 '- r Ô
r-
CL_
v^.^
-p
V
ca
ce
d
tC L
.O a a
O
O
.E
^, L
^,
L L
00 U 0 c- Q U LL a H Q
+J
a
O_ O U
O O
,`^ S u
a O a u
a C
_,
E
Sa
4-
a
^^
a.c L
a
O p t0 N
F- - rC a
C
C
O a
o
O
N 0
C ^n 0 2E
2-c4
-,
m Cro OQ u
+a 'cO '^ E m v Q
p
'X L L U a t6 E
0 r0 a .^ O a
a a a
0 Z
Z U U U r
Eo
a a O }, >,
F- Z W L
D7
Eo
Ln
>
00
^ N
0"
>
Z
L
^f
Ln Ln
In
47
In
Ln
t1 1,O
u') U)
ANNEXURE-1! (Contd.)
`V
C)
Ln
d'
Ln
3Q
C)
Ln
4 4
^^V
a s`
o0
,O Ln , En
Ô
N
00
00
O O v-
O
O
_ N
- ap V
O00000
OÔONONO
7'1
C)
0000000
c) 0c00d^
N N- N Ô O N -
0. NI
. m
o
tom.
N--
NI
0000
C)
L[1
0000
d MAM
0000
O
O
000
00000
d
Lfl
N O O
to r- U
^n
0L
^ ^ O
^ V ^
-
^-'OO
V^
O
OOo
NI000
O
00
e- 00
O
O- N C) N
O
r--
N-
- N M N M O
N N II - M
,
W1
L O
U O O U U
,,,
N
V
QJ
QJ
i-^ .1-^ Y
i
C C C
> >
t/ 1
T1
Qi
.1../
>
LO
U( U U U U O D U U U
U
QJ
E
s
i^
L = L
E
vs to
L
W
i
+.+1-+
L i
^% i^
4-'
++
+J
+J
+J
+J
Q3 a3 N N W 0) N N 4J
îi.ciiii
E J, y-' 1-' i-' .IJ J-' . c:
V
c ^- c c c c c c c c
>
t^ I^ V 1 I^ un 11 O O V 1 LL t/1 t/^
>.
>
In N t/1 N N v1
000U
+J
3-/
+J
.L../
N N N U
iiss
.1_I .1-J a..1 4-a
C C
C
to /1/1u
t
L
ai
O
C
co
.^
U U
+-+ Q Q U v-
> N N N
v-
++
U U
0p
-J
{V
IJ
nxa^
O Q
<-)w
X
x uM u Y L ^+ ta N
^+
O O O K 0 O 5 E 41
82 vuon o
O
L.
N
O
r^
I
`N
d'
D
06
Ln
oz
Ll
48
d
C
U L t
i m
v a,a)
m L
0
t.-
U Z U Z d 0n Q G1 U O- U d 0 d
O ^
A C
Q^
'li
O .9 O C)
O la s- v,
r6
V V
O
\D
1D
N M î
O VM
x-00
C
M
C
O
00
u1 ..O N
+-+ O
=3
00
^ 4^ of D
^3v
O
o0
MO
. .
00
C C C u
COCOON. . . .
OOltic
00
d. O.
00
Oom
N000
OOM
NN,
N;
. . .
.
ooLnm00 ON
000
O O Q
00 O Ln
OOCOMI. N O' o N O( NO, N O O
OOLn
. . .
00
M^
Lr) O
O
itO
.
-N
Q.)
CC
Q O
00
c5 O
M-
0000
O O O O
N CO CO in
Ou"l
O O
O
^. O
C
0
u U
U U U U
u u
u u u
V U U V U u u
u u
N N
L
.h+
C C
N N N N
L c C L
^..i --+
C C C C
a) G)
L L
4-^ 4-I
C C
N N N
L L
a-+ 4-1 4
C
C
N 4) dJ N Q) N N
L L t L L C.
.IJ
J-+ }J 4-I a-+ . 1- ^ a--1
C C C C C C C
a) a)
L c
4-1 a-+
C C
N
L
a-+
C
N V1
t/) N N V)
N V)
N to N
N to V) V
t/1 to N
N In
>+ >.
>
A 7. >..
>,>
>+ > >
>>>>.
A >+
>+
Q)
4-J
a)
r0
a)L0 p
v^ c0
t^ N ^
.o N w V
O
p p
l7 C
N
C C 'C m
-o o N
L l p O O C
O L
2
L
d uwLuwcLUcL E o- d u
co
p
f(C
in E
N
C d
N
j, U j, N
v C
c
x ^ m v
E o
;
Q
XN '
Ep '
L
N
C
N
C_
C_
O
C_
E rtf
p +' w
C
.
ta
N O.. 4J E
p
N
O N (Q _^ -O
..0
Q
L O L
^F- ,L
L U
p
Vf
.1..i
E
L
L
L
L
,i
i i
:.
p O v +r
++ u N O V ,, > M 0 E m E
9 o X
co
tC3 p L QJ tC
a
+-'
p
t0
p_
C O
u
r6 N N v
rtS .^ L
O
J>
V E-> u
O
i
Eo
LC)
-v0NJ
LLn
.1o'.0
N-
Z
kn
'.0
a^.r y Q
3v^
00
Lt
N-
^r
^p
r-
I-
r-
00
10
1n
IPf
O"
L- a
r-
e-
d'
of ^ y Q
0 Q 0C
` 3
O
O
N
Q O
'
O
O
M
O O
^ N
N- N
O'
O- 0 0 0 0 0 0 0 0 0
O
. O O
O O O O O
O
00
'0
a r- O O r- 00 Ln i n N
OrUI
-r0
't Cl
_ U+v
N
10
O
00 -a
O
N- 00
u u
a..+ 4_I
E
i
M 10
o0
^-
O
d
'0
O O O
O O O
N Ln M
' N
'-00 M O
N O O
O
M O O M '.p t M a' N N UI 00
00
M to 'q-
dt
^;
L L c
C
c-A *' N
N O LL
L L
o u u u u u u u u u u u u u u u u u
C C
>>W
V1 V1 LL
a) 4) a1 a) G) O) W O) N a) a> O O N N N
L .0 c L t L L .
t .0 L C L L. L
41 4-1 Y 4-d i.+ +.1 +. i-+ a..+ 4-1 3_ 3_r a_I 4..i 4 J 4-.' yJ
L C C C C C C C C C C C O C C C C C
N
A T
>+
LL t/'f V1 N to VI to V1 V1 N l/I Ln t/1 Vl V) N Vl N
C
0
tCf
oo
+'
aai
'r
v-
4.1
O_
Q T
u
c00
L-
4)
X
}, O
cU
V V m N .c
O
X O
a^
r
N O_ E
Eu u
X O Q
X
u
O O o ate., V
a
I^
N u
L
O _^ O J
u N
0. Ea^ 2 aavaa)0 E
Q
cn V LL V
UI
.0
N-
N-
00
N- N-
N.
N-
0CX
Z V O vI N Z V Q V V V V LL d I^ M V O
r0(:
Z
in
r.
a 4J
O u
u a-+ X L
Q7
Eo
a u
50
Li
.ôO
0
o.
rte,
o^
Lri
Lfl
't
L a
O
r
3 M
CO O
.o
Co
O
NI
H
Q,Q>ha
3 V 4
3kO
O.
00
cc
.
.
N N
N
Lfl LC) I
If CCCCCCCCCCCCC
O Mu r
M O
U -) M Ô. N un o0
i
.
.
.
.
.
.
.
.
. I^. O. O.. Ln. O. O. O. ^D.
. M. ^t. V .
N N O , M O M O - 0 0 0 0 Ô M N N O O O O O O O
O
d
M O
NI-
CC
O
O
CC O
O
O O O O O O O O N M
O
O
CC 0 0 0 0
O N O
O
O
O
O
O
O
O
00
O O O ^D
O' O Ô I
I^
N Ô N O
O
^L
U
Q O
^-
CL ^-
M r- 06 N
* ,O M M Ô O^ ^ M M O M ON M O
O O
4.^
u u U U u U U u U U U U u U U u u U U u u U
v v a, v v a v v ai a v v v a) Q^ v ai a v v:
J
i
i
t t
4
t i
J t i
O V'f V1 V1 t/1 N t/) N N V1 N V1 V1 V1 VS VS t/1 V1 t/1 V) t!S to to
Q
(0
]+
-1-J
-
pl- +O+
to
N2
O
u_ u
.^
L
o0
C
C
c0
i) (0J
_
c0
N
+J N E E
a_ m a^ U X
c
m 1 10
O
fd
f0 f0
:O
f0
O V
fO
-muuâuoc^ôazC)
RS
O2
Q1
Wamza^clI-F
EoU
0' - N M
Co
0'
00
Co
Co
Z
N
O.^
E
a> N iC N O
=min
O
^
C
C N C
C O N N
IOy N X
00 00 CO
Co
51
i+
La
t 12
G^ î
O
O 0
Q
O N O
M
O' r
1O
V .^
C)
C)
Q
M
N
N
oNLC
00
O'
Ln
O'
CD C)
.00
in -
C)
L ry
INN
N O
O
1O
1O
M
o
M
0
0
Lf f
00
.-o
N N
p^
I\
1,0
In
CD O
d'
O'
L
4 0
N r
00 N M 0'
h N
ui
r-
3v
0
O
c00000
CD
C)
OOOCD
0000
O C ^D
't
O
0' N N
ON0'CD
00
000000
MN -'vtC
OOOOLfLncCOOOOONCDLn
Lei ^- I^ 00
Ô N
r- N N
N N V N ^D O
O N ^- M 00 Ln O M
N C' O% oO N 0 N O `Cr O o0 O
O N
N u'1 O'
O L
Q
O
U
Q O
0000000000'00000
N Lfl u") N N I n 7 Lr' M L n O O O O O N O O 00 N 00

r- N N
O O M
O r^ r- I-, 'o r O
.o Lf'f o O
G
C
+ 4_J .J
U V V U V U U U U
U U U U U U U U U(O M(t U U V U U V
+ ++ i_+
^-+ ^+ + +^
+ =+ +
+
+
+ + +^
+ 4- 4- +=
N i=+
4-+
4J N N O 0^ N N O O N O N O N O N N N C C C N N N N N 4J
N N N
L L
L L L t L .0 L L L .0 L
L
C
C
L
L L
,^,^ 4- 4-'
^^^ N
+
N
^^,^^4- 4J4^4-'
E.^+.' ^^.^
C C C C C C C C C C O O C C C C C C O E E
L
to N >-. to >.
> >'
>
N >.1 > t/1
V1 N >. In
V1
>
V>.1 V>1 > t/l
LA
L IE
L
LL N N N to N N
ui
(0
c ^
O
O
_C
E ++
ztz
N&
'J
_C O
O t0
L O
N
p
p- vim
- E E
Eco
p N
_ C O
i]
'V
ELL
0. _
>v0 C)l.~^
-_a,
2J
^n O r , N
n N N
N
N
ca m X .
+.+ O a
X U E 0_ U N X
p
uV
=+, w v
O
N
+^ N ^n
vwQQû^ >iic7^V
in ^p
N N
M
N
-t in
O"
O, O,
1,O
O
Z
L
NE
EoU
Z
_
uso.
X X
RS N
p +,
p
t0 cn
-_
^1
N
I,- O O'
N 00 N
00
N
N-
CO O'
N 00 0' O - N
0000 00 0' O' O'
52
0'
v'
O' O'
cHa
>3v
ha,
r:
N
00
cs
M
O
00
cri
r t cri
N 1O
'.c
^;a
00MOMM000^0u'^^rÔNÔ0^t 0
Ln Zo 00 1M OZ - t
0.I,-M^0000
^ M N N M OZ O Z r f I
u^ Lq N Imo.
I^ I^ N
O ^ . O
O
u1
^
P^ O M O N O Ln ^ O, O O O N ZO I,
O L-
+
o u â
V
Q
O
L
- O'
N .O .f1 O ' -00 N
00 M O\ N Lfl N N
a0 00 O N N O
Ô O O O N ^ ^ O 00 ^
O' O
00 '0 O .-'
^.n
M_
O^
O 00
O M O O O O O O O O O O O O O O r- N i.rf N ^t O O O
- j
O
O
-
u u u u u u u u u u u u u u u u u u u u u u u u u u u u
N N OJ N N N N N N N N N N ai O N N N O N N N N N a) N N v
L L L L L L L L L L L L L L L L L L L L L L L L L L L L
4' }J 4
i..+ 4..1 4J
4 4? .FJ
4..+ a ..l 4-) 4J yd 4-1 4-1 4-1 4-1 4-1 a-)
4-1
4- +
4--'
> T > T
>
a-)
t/1 cn N to VI N N N V) Ln V1 N N
Vl Vl
to
> >,
Vl V) V)
O_
Q)
C U v ^_ O O
^_Q
____
li J V
O N O u
'^ p `^ '^
-
0LL
cn J
ate+ O. C
N N F-
O
E
N ^ L N
LL
-' O E
E
D N
V1
V N
N a tCS u O
v= m ao
4-''-X.- E
O to
W to Z O=
E N Ln L
: 0n L- Z
N d
X_ C
o^
O Z
0NO
0MO 00
M d'
oi
o
53
ei
4-'
Ei >.
O O t6
N N to Ln to N N N In
N
-D
N
> > >' > > >
41
4-J
4-+
O O O
p3v
'
00o
If
I-
^
'-
"
00
a L
3
S V
Ô
O
N o o O
IO Ô 0
O O O O
h
'O
Ln
OOO
NN
- N O
aa
.o 1.O
O O O
Z Z O
CDLn
O u'f
Mmenc
i1) N O
N .-
-Oc ô
OL
CC
Q L
a `..
^M l^ Lfl
^CO0CC
N 00 O
O r- ^ 1,0
N. r- M M S
00 M
--
r0--
od
O O O
0
4 07 Vj
u u u u u
N 4) N 41 N
.
L.
u u u u u u u u u
N 41 N N Q N 41 aJ N
41
4.1
N Vl N to In
L L L
l.J
4J
u u u u
O) N N U1
4J
c c
to t!1 N t/1 In N N N N
.N
_c O
o->
a -.;
'>
O c^ w O o C C O
O
O O -O
L O
xv
a^x 0=u
ai >. m
I.
I.
L//W)
}, Ec_ a^c'Lc
Vl Lra u
o
U a, v E E c
rts
o0
â
os^_
of
Q E O
u u u
N N N
^
E
E o
cu a^c v vv o
c .^ co
mu2^^ oiJw<ZZlyo)
4.J
N ^
Ci
N C O
}J
l!1 In LA LI
o c
_= c= c ^.c
a,O Nc N>+ u)C ò > OX ûX
L t L
c c c c
i-
E
x O
C
X X
O O C M
L > L
.1..i
m cv x coa 4c .^
v a,
C
t0
N
o o
vlQZUUClz0zCl
cz
a aa
Eo
v1
CO
Ô
O
I^
O
00
O
oo
O
r-
00
'
00
N
.-
54
Annexure-111
LEVEL-II QUESTIONNAIRE
Summary Sheet
1. Manufacturing Facility Address
2. Corporate Address
3. Respondent, Designation
4. Manufacturing operations in addition to bulk drug manufacturing in the same

facility*
Manufacturing of raw material/intermediate for drug (please specify the name of the
drug for which the ra material/intermediate is produced)
5. (a) Bulk-drugs Manufactured

Whether plant for the drug is dedicated (Y/N)
Drugs
5. (b) Drugs sharing the same manufacturing facility
6.
Total Water Consumption (m3 /day) for the whole facility.

Mention the sources for which the water consumption is given
(Process + Utilities + Services** + Gardening + Any housing colonies + mention any
55
Annexure-111 (Contd.)
7.
Quantity of Water (m 3 /day) purchased by the industry or in case of borewell

auantity of water drawn (SDecifv the source from which the water is purchased)
8.
Cost of Water (purchased and/or procured from public/industrial estate supply

and/or around water cost of DumDingl
9. Quantity of wastewater generated (m3/day). Also give the input/output

characteristics of ETP alone-with the treatment flow diagram
10. Water Usage(m 3 /day)

If Season-wise variation

If uniform throughout the year

Depends on campaign of
production ***
Peak Season usage:

Lean Season usage
Usage
:
Maximum usage during the campaign involving

drug
(s) is
(m3/day)
Minimum usage during the campaign involving
drug
(s) is
(m3/day)
Please add new sheets where space falls short.

Mention the chemial products the facility has license to produce.
**
Services means floor washings, R Et D labs, domestic, any other
***
Example
Campaign 1: Bulk-drug 1, Bulk-drug 2 and Bulk-drug 3
Campaign 2 : Bulk-drug 1, Bulk-drug 2 and Bulk-drug 4, etc.
56
Annexure-!!! (Contd.)
Drug Sheet * $
1.
Drug, production capacity Ft current production (ton/month)
2.
Starting material and intermediates @ of manufacturing (please

mention the raw material/intermediate @ from which the drug
synthesis starts)
3.
Whether the intermediate 0 is (mention each intermediate

separately)
Imported
Indigenously sourced
If yes, please mention the name and

the address of the Indian Plant from which
it's sourced (Not required if Non-Indian Source)
Batch size of
drug (in tons)
4.
Batch time
(in days)
No. of production
days for
manufacturing a
ton of drug (in
days)
No. of days
plant is not
operated in a
production year
(in days)
Water balance for a ton of drug
Raw water input (m3/ ton of drug manufactured)

Process water (consumed/ required in reaction(s) (m3/ton of drug
manufactured)
Reactor washing (m3/ton of drug manufactured)
Water used to dilute raw material such as ammonia soln, acid, alkali
soln, etc. (m 3 /ton of drug manufactured)

Quantity of water/ any other (if water is a constituent) recycled/ reused
in the manufacturing process/ elsewhere in the plant (m3/ton of drug
manufactured) - mention the activity in which it is recycled/ reused.
57
Annexure-111 (Contd.)
5.
Effluents characteristics from the drug stream wise (Mention the

steam source)
Steam 1:
TDS:
Steam 2:
TDS:
Steam 3:
TDS:
Add more sheets as required
6.
COD:
COD:
COD:
Attach the process flow sheet showing water consumption and

wastewater generation (m 3 /ton of drug manufactured)
Use one such sheet for each drug.
In case the drug synthesis does not start from the basic stage.
Refer to the exemplary questionnaire attached herewith
DRUG WISE UTILITIES SHEET
(fill for the utilities existent for the drug)

(all quantities for a ton of drug, in m 3
)
1.
Water consumption in Boiler owing to the drug along with the water
consumed in the evaporator, if any : (in m 3 /ton)
(apportion the losses and corresponding make up quantity attributable

to drug)
2.
Water consumption in Cooling Towers owing to the drug : (in m 3 /ton)
(proportionate the losses and corresponding make up quantity due to

the drug in case the cooling tower is shared with other production
activities)
Dedicated Cooling Towers (process) :
Mention type once through or recirculating
Mekeup (blow-down + Evaporation tosses + other losses) of water (in
M3/ton):
Shared Cool Towers:

Mention type once through or recirculating
Quantity of water (in M 3 /ton)
58
Annexure - li! (Contd.)
3.
Water consumption in Soft Water Generator/ De-mineralised water

generator owing to the drug:
(quantity of soft water used in the drug manufacture, in process and

pollution control equipment)
4.
Water consumption in Pollution Control Equipment
(attached to the drug process)

Scrubber
Numbers
Mention type, scrubbing media and

pollutant scrubbed:
Mention any other pollution control
equipment (if any)
59
Annexure-!V
...C)
o000Ln0
3 i
p "^
I 3 E
O'. N N.
'
O" 00 N
00 M Lf1 O N. 00 LA N.
000 N M a' d Q'
- - LP) N M M r- M
00 N '.G 00 d N CO O'
N r-
oom
r- U
00 LC
a'
M O N
10
00 I^
N.
M r: o î
o:
'.0
M 00 - O N. '.O M
OO Ô N N "0 Lr e- a' 00
^î 00 p
N Q>
U
p'
3 E
LU
a
Z
p ^
Lfl r-
M N O V"
"f
": ^
r-
6f'f '1'
v- N.
C)
OOO
O
" B 00 Wi O
r - e - '.O r
N N N.
000
O"
00 N
M 00 ir') CD
Lri
Wi N r-
V'
N'---'J-
O
O
O
O
ì 1
M
1
NO
N
O
CD
0001-1 00 N.
'ocI-,MMO0a0N.
'c O O '.O O 00
d
M O N. d' N ^T ^ O,
N O M d' N ^- 00 M
d'
O 'O 00 N 00 O M N W
M "g- V O N. g>
N . '.O '.6 00 O
cT N. N r- M
N -- Wi N
Ô
N O
, o
N O ^- M
_0
O' O N
LC O' O N.
ir'.Oa0M,'I^^r'â0O06ON
N. M t
CT 00 M N. M 0 r
M
O,
C' Wi ^- '.0 O'
'.O '.O r - iN '.0.
N.
O -.
N. N
O
d- .O
Igor
f;MN
Ô
Lt
O 00
cri oo . M
N O N. M
00 ce
Ln d' '
N. t-- M
O
O ire
O H O N. m a' N.
Q\
N I^ I^
O
O ^
'.O r-
M0 O
wi O M '.0 a'
O O M- N. O' N
d.
d a'
co
00 O 00
N 00
00
M
'00 0 O' O
p 't M O N '.0 .0 't M 00

00
00 -t M M '.
r- O,
NLt 0
.J L p V 't
O O O N V O
p ^; %
1.O M O '.D O N. t 'c
-s
L
O0
C)
C)
C)
00
000
a 0d00 r;
,
C)
OO
O O O O O O o O O
'.0 N 00 10 O N
00
'O
OOOOO
00 M e- ^- Lf^ N M O' M M ^-
'.0 N M
M r M r- 'q- o r-
^J;c;R"'^.^^
m O -10 M %D L)
N O O
d
J
W
>
W
J
E3^c7
CO N N N 00
0 N
U
0
"4-
M M M M
O
Lr
r) IN. a'
a' N. ^
00 N Ln
DDDD
N
W
N
0
a
tk1
_
O
E
co
t3
co
o2
a
v
I..
L j Z
u
n!
in
uon
O
a v c
(D
E o '- o o 0 C Q
= _.
vnu<uv >>
"^ x
O O O
-5LLrb
to
Q 0
O
X
's
vOi
pip
O^'
: c u
-
N
Ox
m
F^-
Rl
^s^
cog
C îf
t/!
^c
c^
QW
a+
o
m
C ^`
^5
aaa^,a
a>
<
a^-a
r-
M ì
1-c 00
o'
O
r
r--
Lf1 'O
60
O
O
E
r
Annexure-IV (Contd.)
'.0
p 0> >>
pil
~ C
3 tNL
'.O
Nr
00c
N-
M
00
Lfl
'.0
Ln
0O
.j, .
O
o
j. O M
r 00
co
in O N't
M M 00 O
M
N-
co
Ol,
hl
.o ir M
M O>
00 ^
if
.Q; 2
a`
v'.
O O ,^
I^ 3
cri
^r
O'.
00
'.0 C)
tf1
r-
I! O O O
O'. u
N- O M O
N- fV O"
CT M C) 't C) 00
r; . - N d ^n ri
C)
r-
UI ,
--
N- '.D L.n
ri .^
N 00 M M fV
UI
aL- e
p
CD
O
C)
00
N
fV N Oo 00 M
M
.- '- Ln
tt
CD I'. c
c
O N
N
Ô r M Lf1 CT
in
O O
CD C) O_
Qj N
a
L 3
^\
'.0
M O O D
t C) O O
'.0
-
o Ln
LA
UI 00 00 00
O M
UI N M N-
O O
N O
c.i
CD
^-
CD
r
r-
000
N O
Lf
'.O
tt^ O
O N 00 N Ill M
- r-
O d C) O
CD O
t- N-
o 0
O
p`
p L
C) O O
00
O O O O O'.
O h. O O O O O
06
N"q
06 r 06 N R N N
o'
0'.' 'l
00 - 00
M-
0'
' t`
'- O'. N NI.
r- UI
N N M
't 't
fV
'.O M
co
dU M N N N N
C)
N 00
DD
_
a)
C_
0^
O N
-+ C
'
^_
-0
E O O
OC E
_d N
0)4
>
In
U
zE amI-o
L O
EI.) Z
N
E
NE
c v c
a=a=
N
M
r-
1
v
c>
a=
uin
>
OiZc
_j
oDo
V)
W q)
+,+
ua
wE
:E
rC a) N
^.
o
E
c
c `^ c c
aaa Maa
uc
UP
.-
^p
C NE
0-O0-L)
OJZOUXZti.
N V2
ON
N N
L-= CD 0
'.p
r-
61
Op 0
r
C) 'N N
Annexure- V
4.J
W
W
'A
VI
C
47
N
W
to
In
C
0U
n
1O
C
l- a
E
0
U
4-
O
O
c^
92
62
Annexure -V (Contd.)
M
O
O
C)
0
0
41
L
IZ
(I)
r.y U
,Q O
O
C
O
F=+
E
C
O
U
4--
O
O
63
Annexure-V (Contd.)
r r-
Ni
O
Co
J--'
d-^
.E (n
V)
I/
O
0
Q
C
0
U
w
64
Annexure- V (Contd.,)
rn
tD
j)
0
O
O
%i
I+I l^
. :n
N ^
C^ Q
^ O
-o
Q
C
0
U
4-
0
O
B
65
Annexure- V (Contd )
a)
Z 0L
ct
o
a ^
w
0
0
P4 Cl
0
U
4-
0
0
cO
Annexure- V (Contd.)
P.
U,
_J (t)
cl)
C C
OCO
2E
CL
1-
W CL
(n
L-
ei
U)
co
UI m
fl3
4J
LU'-
,-0
U,
4J
,a)
w
I-
ci U)
'L
4-
ir
LU
U)
I--i
to
LU
:3
-J
X to
KL
UU
LU
E
cl)
U)
0
U
C
0
4-
(D
0
(U
()
O
co
ba
Z
Z
LU
'e-
Qc'J
i5
Ei
Q.
-
CD
cn
am
C,)
LU
4J
$3
LU
co
II
z
E
tK
CL
9-
0
C
0
.71
E
., 0
< 3cs..
0.
oE
Q
(I)
C
0
U
2a
4-
0
0
ru
cz
0 E
CO
1
f- FE
ri
68
.-N
M
O
L
C)
4J
0
0
a--I
C)
4J
r.
^r
U
4--
O
C
C)
4J
c.
C
0
U
4--
0
0
L.L
Annexure- V (Contd,)
a)
-
4W
,-i
a)
-I-J
to
-I--I
C^
Q)
C)
4-.
O
C
O
4-0
U)
0
U
O
0
f0
70
M
O
L
a)
ca
0
0
'U
4J
0^
r
F^1 U)
Q)
iT^ri Q
Z -
O
Q
1
V)
W-
O
O
c0
71
Annexure- V (Contd. )
00
aD
CD
Co
0
0
v
u
CD
CU
O
C
0
O.
E
O
V
4-
0
0
4J
CD
72
M
O
ca
3
1--,
b O
^^ Q
..r
E'4-
U
EO
C
O
()
O
O
to
73
Annexure -V (Contd)
00
a)
2
U
Q
L-
cn
C N
ii
E.
74
Annexure-V (Contd,)
N
N
4--,
co
co
a
I.'

U
0
o
C
0
C
0
U
0
0
0
e.4
75
1-.
00
co
CD
1--,
o
R
4'
0
L
CD
(n
^
U
w O
C
O.
^V O
^= ^ OC
a
a
O
co
76
Annexure -V (Contd,)
N
O
L
G)
0
0
L
ll
r_
1
U,
0
U
O
0
Co
oC
77
1-.
U)
ca
i
o
0
Co
(n
U)
U)
U U
10
CL
ri C
0
c.
E
1
C
0
U
W-
0
0
78
ZE
zge
eo
0
'I
U)
co
U)
t 91
.
4-J
o
L.
I)
IE
i1
j
W.
o
4J
t-
0
I-
FI
E
U)
EO
0
U
4-
0
0
(0
11
U) ,
W
El
79
f-
Annexure -V (Contd,)
I
O
2
t
2
O
2
2
(1)
L
a
Vi
v1
U
4
0
0
ra
:; iJ
O
0
L
t
3
a
U)
n
O
c
0
cl
E
U)
a
U
0
0
rU
81
rn
O
L
QD
12
o-
Q)
U
3 O
4J
aO
E
rc
0
U
4
O
O
ry
82
00
a)
0
I-
a)
a ra
Lfl
U
0
9-
O
O
C
O
U
9-
0
0
cB
92
83
z
-
(4
W
4)
2E
to
0
IN
a:
a:
to
toE
C-)
(t)
cs
(D
00 E
zo
4)
U)
U)
S
S
2CL
q)
4J
>
U)
'- >
U)
U)
U
0
'1)
U
0
1.
4-
CL
z
LU
94)
LU
WE
0
wz
-J
-J
LU
4J
cL
E
(1)
0
U
1-
0
0
g)
to
j
H
EI I
I-
4)
(4
4)
84
Annexure-V (Contd)
4J
E
U)
I_
a
O
V0
4J
a
E
3
C
0
V
O
O
85
In
N
U)
Co
0
S
a-.1
o
E
IC
IC
IC
4-
C
0
E
ui
0
U
4
0
0
cv
C2
ANNEXURE-Vl
Sr.
No.
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
Level-I Calculation of Utility Water Comaanv Wise on Prorata basis

Utility
Process
Name of
Drugs
Actual
water
Production
Water
the
(M3/ ton)
company
(MT/ Year)
Cons.
M 3 / ton
60.29
U1
Ranitidine
216.00
0.00
60.29
216.00
26.76
Dictofenac sodium
68.95
U1
Tinidazole
600.00
4.82
13.79
120.00
11.33
Nimensulide
0.00
0.00
U3
Ethambutol HCl
Not Manufacturing
U91
0.00
U2
Metronidazole
602.25
36.86
0.00
Methyl Nicotinate
0.00
Benz l Nicotinate
0.00
U4
Chlor ro amide
3.60
413.34
Penicillin
636.00
106.92
U5
Erythromycin
708.33
62.39
96.00
194.97
Yeast
300.00
85.00
77.99
Ceph-C
120.00
113.33
Not manufacturing
U94
17.00
0.00
U7
Chlorpromazine HCl
10.00
2.9.68
U8
Frusemide
55.80
152.33
354.17
18.03
Gl benclamide
4.80
0.00
Dapsone
40.00
39.95
U9
7391.30
0.00
Az throm cin
0.14
Roxithromycin
537.97
0.00
1.58
0.00
3187.50
0.08
Ac clovir
564.05
51.60
135.08
U10
Am icillin
312.85
30.00
153.00
Ce halexin
54.76
11.42
U11
Pentox f lline
8.93
27.95
Berenit
92.68
4.56
0.31
Ciclo iroxalamine
244.80
0.05
0.00
Barai ancatone
0.00
1.84
Ramiprin
0.30
21.53
0.87
101.74
NNDMMT
16.59
0.00
0.00
Ox clozomide
0.00
0.00
Barai an amide
89.65
14.70
15.73
Tono hos hon
11.65
76.41
Roxatidine
1.90
47.22
56.25
7.70
Aartocaome
Iso propy l antipyrin e
0.00
0.00
27.47
113.84
4.48
ACME
27.06
299.72
Phenira mine Maleate
48.87
257.11
Frusemide
41.92
72.59
87
Overall
Water
Cons.
(M 3 /Day)
225.00
225.00
10.00
22.58
Data N.A.
4000.00
45.00
100.00
100.00
194.00
1000.00
ANNEXURE-VI (Contd.)
Sr.
No.
Name of
the
company
14.
U6
15.
U12
16.
17.
18.
19.
20.
21.
U13
U95
U96
U97
U98
U14
Drugs
Gl benclamide
Tolbutamide
Vitamin C
Amphotricin
Caffeine
Theobromine
Theo h lline
Paracetamol
Not manufacturing
Not manufacturing
Not manufacturing
Not manufacturing
Am icillin
Betamethasone
Dexamethasone
Ethamtuttol
Gl benclamide
Mebendazole
Ranitidine
Theo h lline
Tinidazole
Trimethoprim
Ce halexin
Acr clovir
Adrenochrome
monosemi carbazone
Amlodi ine Bes late
Atenolol
Carvedilol
Cefotaxim Sodium
Ceftriaxone sodium
Cimetidine
Ci roflaxacine
Ci rofloxacin HCL
Dexamethasone sodium
phosphate
Diclofenic sodium
Diltiazem
Nala ril maleate
Famotadine
Fenbendazole
Fluconazole
Fluoxetine HCl
Actual
Production
(MT/Year)
Process
Water
Cons.
M 3 / ton
Utility
water
(M3/ton)
0.00
0.00
520.00
1.20
54.00
56.00
72.00
950.00
162.15
14166.67
157.41
303.57
141.67
14.32
0.00
0.00
79.61
31342.54
24.74
25.65
32.99
22.15
120.00
1.00
3.00
150.00
12.00
12.00
6.00
6.00
9.00
12.00
12.00
18.00
0.60
27.77
3332.00
1110.67
22.21
277.67
277.67
555.33
555.33
370.22
277.67
277.67
185.11
5553.33
19.74
0.16
0.49
24.67
1.97
1.97
0.99
0.99
1.48
1.97
1.97
2.96
0.10
6.00
6.00
6.00
12.00
12.00
6.00
60.00
60.00
2.40
555.3
555.33
555.33
277.67
277.67
555.33
55.53
55.53
1388.33
0.99
0.99
0.99
1.97
1.97
0.99
9.87
9.87
0.39
6.00
6.00
6.00
24.00
6.00
6.00
24.00
555.33
555.33
555.33
138.83
555.33
555.33
138.83
0.99
0.99
0.99
3.95
0.99
0.99
3.95
88
Overall
Water
Cons.
(M 3 /Day)
422.00
258.00
156.00
80.00
490.00
Sr.
No.
22.
23.
Name of
the
company
U15
U16
24.
U17
25.
U18
26.
U20
27.
U19
Drugs
Actual
Production
(MT/Year)
Fluvastatine sodium
Furazolidone
Gemfibrozil
Lanso razole
Loratidine
Losarten Potassium
Meloxicam
Nicorandil
Nifedipine
6.00
6.00
0.60
12.00
3.00
6.00
6.00
6.00
9.00
Omeprazole
Panto razole sodium
Paroxetine HCVI
Phenformine HCl
Phenytoin Sodium
Rifampine
S arfloxacin
Terfenadine
Ticlopidine HCl
Tramadol HCl
Trog
Gl benclamide
C H Base
Loratidine
Fluoxtine
Ethambutol
Pyrazinamide
Isoniazide
Niacinamide
Di-basic CaPO4
Tri -basic CaPO4
Diazepam
Chlordiaze oxide
Salbutamol
Danazole
Salmeterol Xilofoate
Finasteride
Ci rofloxacin
Norfloxain
Ci rofloxacin
Fluconazole
Estramustine NaPO4
Lamotrigne
6.00
6.00
12.00
12.00
6.00
6.00
24.00
6.00
6.00
12.00
6.00
12.00
36.00
2.00
3.60
60.00
175.00
0.00
0.00
10.00
20.00
9.20
3.50
5.40
2.38
0.39
0.69
1.95
Process
Water
Cons.
M 3 /ton
555.33
555.33
555.33
277.67
1110.67
555.33
555.33
555.33
370.22
555.33
555.33
555.33
277.67
277.67
555.33
555.33
138.83
555.33
555.33
277.67
555.33
680.00
188.89
3060.00
1511.11
119.00
23.31
680.00
119.00
70.22
77.71
3146.40
0.00
0.00
0.00
0.00
Utility I
water
(M3 /ton)
0.99
0.99
010
1.97
0.49
0.99
0.99
0.99
1.48
0.99
0.99
0.99
1.97
1.97
0.99
0.99
3.95
0.99
0.99
1.97
0.99
25.02
75.07
4.17
7.51
125.11
82.80
0.00
0.00
19.16
38.33
59.03
22.46
0.00
0.00
0.00
0.00
0.00
1118.67
492.56
80.13
142.03
402.71
Overall
Water
Cons.
M3 /Da
250.00
55.00
NA
22 20
78.50
176.00
ANNEXURE-Vl (Contd.)
Sr.
No.
Name of
the
company
28.
29.
30.
31.
32.
U99
U22
U100
U23
U23
33.
U24
34.
U26
Drugs
Not manufacturing
Paracetamol
Not manufacturing
Gl benclamide
Cetrimide
Benzalkonium Chloride
Ibuprofen
Ciproftoxacin
Ranitidine
Doxazocin
Amoldi ine
Carvidiot
Celecoxib
Cetrizine
Cislactum
Dexomethorphon
Dilitiazem
Domeperindone
Enata ril
Enrolflaxacin
Enrolf loxaci n /
Intermediate
Famotidine
Ftouxetine
Flucanazole
Keterolac
Lanso razole
Lomeftoxacin
Losartan
Naproxen
n-Benzyl Piperidone
NMCP
NMSM
Norftoxacin
Omerprazote
Ondansetron
Panroprazote
Pefloxacin
Setrline
S arfloxacin
Terazocin
Quin-iodo Chlor
Actual
Production
(MT/Year)
Process
Water
Cons.
M 3 /ton
Utility
water
(M3/ ton)
Overall
Water
Cons.
(M3/Day)
500.00
27.20
42.09
53
8.50
42.00
158.00
900.00
444.00
600.00
1.20
1.80
1.00
5.00
0.20
20.00
25.00
25.00
5.00
7.40
152.00
72.00
24.00
0.00
0.00
79.18
69.86
32.60
79.18
209.59
232.88
232.88
27.95
232.88
232.88
232.88
232.88
9.32
69.86
107.12
588.53
1.59
6.00
23.43
11.56
15.62
0.03
0.05
0.03
0.13
0.01
0.52
0.65
0.65
0.13
0.19
3.96
1.87
23.30
7.10
15.00
2.60
1.50
2.40
4.80
5.10
6.50
240.00
30.00
10.00
360.00
78.80
12.00
0.60
1.30
4.00
2.00
8.80
0.60
145.00
121.10
83.84
232.88
27.95
279.45
83.84
232.88
121.10
232.88
232.88
139.73
83.84
139.73
79.18
223.56
83.84
232.88
93.15
79.18
455.37
0.39
0.07
0.04
0.06
0.12
0.13
0.17
6.25
0.78
0.26
9.37
2.05
0.31
0.02
0.03
0.10
0.05
0.23
0.02
214.61
90
1370.00
348
Sr.
No.
Name of
the
company
35.
U25
36.
U27
37.
38.
U101
U28
39.
40.
U102
U29
41.
U30
42.
43.
44.
45.
U31
U32
U33
U60
Drugs
Vitamin E
Guaiazulene
Clarithromycin
Roxithromycin
Erythromycin ethyl
succinat
Celecoxib
Ropecoxib
Sibutramine
Not manufacturing
Salbutamol
Miconazote Nitrat
Flurbiprofen
Bromhexine HCl
Timolol Meleate
Flucanazole
Cinnarizine
Not manufacturing
Etidronate Disodium
Permethrin
Sul hamoxole
Theo h ltine
Xanthinol Nicotinate
Trimethoprim
Bisacod l
Eto h lline
HPC
Mesterolone
Ranitidine
Salbutamol
Griseofutvin
Lignocainee
Miconazole Nitrate
Lidocaine HCl
Ketoconazole
Herbal extracts
Penicillin
CMAOMG
MBOPNE
DMBOPNE
CFB
RPI
MPTB
Actual
Production
(MT/Year)
Utility
water
(M3/ton)
250.00
1.50
4.80
9.60
4.80
Process
Water
Cons.
M 3 I ton
43.52
1813.33
96.33
35.42
15.44
1.90
0.90
0.90
10.74
35.89
126.93
0.00
0.00
0.00
9.75
12.60
7.80
16.80
0.19
0.56
2.30
104.62
809.52
871.79
303.57
8994.71
5435.17
886.96
44.40
57.38
35.52
76.51
0.86
2.56
10.47
0.10
0.07
8.41
39.00
11.90
0.00
1.88
100.00
1.24
0.09
127.55
0.05
14.42
2.00
6.00
2.00
0.60
0.25
1512.00
1.00
0.50
0.15
0.45
45.00
30.00
0.00
0.00
1374.55
340.00
685.71
0.00
0.00
2.00
10.19
3.11
0.00
0.49
26.12
0.32
0.02
421.07
0.17
47.61
65.64
196.93
65.64
19.69
8.21
401.58
15.06
7.53
2.26
6.78
677.69
451.79
43.22
0.26
0.00
0.00
0.00
Overall
Water
Cons.
M3/Da
122.00
N.A.
91
2893.62
190.40
2467.74
30909.09
159.94
6415.09
1060.95
612.00
527.00
1683.00
2380.00
8160.00
326.06
6800.00
13600.00
4533.33
60444.44
680.00
226.67
178.00
358.00
380.00
29.40
4180.00
547.00
Sr.
No.
46.
47.
Name of
the
company
U103
U43
Drugs
MP
ACL
Not manufacturing
Betamethasone
Clarithromycin
Roxithromycin
Fexofinidine HCl
Pentazocine
Atovastatin Calcium
Not manufacturing
Amodia uin
Chloro uin
Dichloro uinolene
BCFI
Chlorinated Compound
Dimethyl Compound
Probenecid
Amodia uin
Chloro uin
Frusemide
Pyrental Pamoate
Trimethoprim
Atenolot
Flume uine
Metoclo oramide
Morental Citrate
Marasept
Metoclhloro aniline
Dichloro Toluene
Not manufacturing
Metronidazole
Nifedipine
Cefixime
Cephradine
Ce hadroxil
7-ADCA
Mebendazole
Tetra Bromo BisPhenolA
Not manufacturing
Ethambutolhydrochloride
Vitamin B6
-
48.
49.
50.
U104
U36
U35
51.
52.
U105
U106
53.
U38
54.
55.
56.
U39
U107
U40
Actual
Production
(MT/Year)
Process
Water
Cons.
M 3 / ton
Utility
water
(M3 /ton)
0.06
2.50
17000.00
6800.00
0.90
37.65
0.30
17.10
0.00
6.20
0.35
0.36
113.33
79.53
19.26
1098.09
0.00
398.14
22.48
23.12
120.00
530.00
13.70
0.90
0.00
0.00
0.00
4.00
10.00
18.00
38.00
25.00
137.00
54.00
5.00
14.00
63.00
98.00
131.00
20.49
27.01
22.34
0.00
65.45
18.36
46.97
41.81
46.78
67.45
34.00
80.92
52.46
13.49
3.57
83.73
12.47
55.06
1.42
0.09
0.00
0.00
0.00
2.21
5.52
9.93
20.97
13.79
75.59
29.79
2.72
7.72
34.76
54.07
72.28
144.00
15.00
3.00
20.00
20.00
120.00
24.00
600.00
11.81
0.00
6233.33
0.00
19.65
2.05
15.69
104.60
0.00
502.92
5.38
627.61
0.39
9.83
593.16
53.88
94.79
0.00
92
164.52
145.71
141.67
0.00
Overall
Water
Cons.
M3 /Da
145.70
167.00
731.00
16.00
705.00
60.00
844.00
Sr.
No.
57.
Name of
the
company
U40
58.
U41
59.
60.
U42
U43
61.
U44
62.
63.
64.
65.
66.
67.
U45
U46
U108
U47
U49
U48
Drugs
7ACCA
7ADCA
2-Cuano Pyrazine
Rifampicin
Rifamycin(S)
Lovastatin
Am iciltin
Cloxacillin sodium
Ephedrine HCt
Ci rofloxacin
Norfloxacin
Ciproftoxacin
Norfloxacin
Pefloxacin
Bunebsykude
Ac clovir
Drug Intermediates
Chtormphenicol
Plamitate
Chloramphenicol
Powder
Piperazine Citrate
Piperazine Hydrate
Piperazine Phosphate
Piperazine Adi ate
Chtorpheniramine
Maleate
Erythromycin base
Erthyomycin Stearate
Erythromycin Estolate
Prochlorperazine
Maleate
Chlorhexidine
Gluconate
Prochlorperazine
mes late
Povidone Iodine
Potassium Iodine
Chloramphenicol
Plamitate
Loratidine
Vitamin B12
Actual
Production
(MT/Year)
41.81
282.60
0.00
20.00
0.00
100.00
1.11
2.81
174.20
240.00
216.00
120.00
132.00
72.00
132.00
30.00
Process
Water
Cons.
M 3 / ton
455.39
120.31
Utility
water
(M3 /ton)
50.00
24.14
6.68
45.16
0.00
304.27
0.00
1521.35
318.99
806.39
437.68
6.77
6.09
7.10
7.80
4.26
36.59
1236.25
0.00
0.66
42.00
3.24
0.56
50.00
10.00
5.00
10.00
4.00
2.04
13.60
20.40
10.20
0.00
0.66
0.13
0.07
0.13
0.05
2.00
8.00
8.00
5.00
136.00
34.00
212.50
51.00
0.03
0.11
0.11
0.07
4.00
34.00
0.05
0.05
0.00
0.00
8.00
6.00
50.00
0.00
0.00
24.14
0.11
0.08
0.66
12.00
0.90
232.73
20493.31
1118.95
0.00
93
6800.00
27.20
58.20
26.66
234.21
28.33
11.02
56.67
15.45
28.33
51.52
170.00
Overall
Water
Cons.
(M 3 /Day)
1100.00
33.00
394.25
45.00
50.00
32.00
167.00
13.00
51.01
600.00
Sr.
No.
Name of
the
company
68.
U50
69.
U52
70.
71.
72.
U51
U53
U54
73.
74.
U109
U55
75.
76.
77.
78.
79.
U56
U57
U57
U58
U59
Drugs
Ranitidine
Ci rofloxacin
Pheniramine Maleate
Vitamin B(2) 5
Chlorpheniramine
Maleate
Mepyreamine Maleate
Dex. Chlorpheniramine
Meleate
Vitamin A
Ce halos orins
Hepatitis B Vaccine
Not Manufacturing
Chlor ro amide
Oxytetracycline and its
salts
Salinom cin
Norfloxacin
Ciprofloxacin
Amidopine bes ylate
Ce halexin
Cefaclor
Cefuroxime Axetil
Cefpodomioe Proxetil
Flucloxacillin
Pentazocine
7-ADCA
3-Chloro-7 ACCA
Ce helexin
Dox c cline
Ranitidine
Amox cilline
Silver Sul hadiazine
Calcium Lactobionate
Ferric Ammonium
Citrate
Tri -Potassium di citrate
Bismuthate
Calcium glue Bionate
Calcium Bromo
Lactobionate
Parachloromethax lenol
Actual
Production
(MT/Year)
165.00
225.00
0.03
0.37
1.71
Process
Water
Cons.
M 3 / ton
72.12
12.89
13600.00
186.30
416.57
Utility
water
(M3 /ton)
72.98
99.52
5.35
65.09
305.65
Overall
Water
Cons.
(M 3 /Day)
265.00
19.30
1.53
0.04
332.68
18888.89
273.37
6.42
23.50
625.00
8 Million
doses
2821.28
108.80
1827.50
2789.36
252.82
0.00
70.00
84.57
374.00
900.56
252.90
307.95
48.44
32.00
0.03
0.06
330.50
60.8
4.1
3.8
9.3
2.00
293.1
50.1
8.62
63.17
16.31
40.80
53.97
10.29
44.74
414.63
447.37
73.12
680.00
96.28
705.79
236.66
48.79
0.13
42.50
24.40
5112.78
40.00
41.80
176.39
114.28
0.09
0.22
245.48
45.16
3.05
2.82
6.91
1.49
217.70
37.21
5.31
257.41
0.00
0.00
0.57
180.78
103.79
2.40
566.67
10.21
0.23
0.10
2956.52
6800.00
0.98
0.43
295
2.65
12.66
418.16
480.00
360.00
165.80
727.00
13.69
1500.00
694.00
121.00
39.66
Sr.
No.
Name of
the
company
80.
81.
82.
U61
U62
U63
83.
U66
84.
U67
85.
U68
86.
87.
88.
89.
90.
91.
92.
93.
94.
95.
96.
U69
U110
U64
U65
U70
U71
U72
U72
U75
U76
U73
Drugs
Clofuzamine
Ranitidine HCl
Ibuprofen
Mefenamic acid
Dictofenac sodium
Piroxiciam
Naproxen
Omi razole
Lanso razote
Itraconazole
Enala rit Maleate
Albendazole
Benzthiazide
Norfloxaxin
Pefloxacin
Metformin HCl
Ditoxanide Furoate
Terbutatin Sulphate
Tramadol
Hydroxyethyl
P rrolidine
Fexodenadine
Pencillinamine
Not manufacturing
Ranitidine
Mebendazole
Vitamins Folic acid)
Paracetamol
Ce halexin
Cefadroxil
Carvidilot
Clomipramine HCt
Ornidazole
Pentoxi h lline
Tinanidine
Ibuprofen
Imipramine
Phen lbutazone
Carbamazepine
Erythromycin Et its salts
Amox cillin
Ampicillin
Actual
Production
(MT/Year)
10.00
360.00
152.00
8.00
27.00
4.00
10.00
6.00
3.00
3.00
6.00
9.42
1.83
120.00
36.00
120.00
30.00
0.90
3.00
9.00
Process
Water
Cons.
(M 3 /ton)
68.00
9.08
74.52
23.38
41.93
55.25
144.50
31.17
96.33
102.00
39.67
216.47
557.38
7.08
18.89
0.00
0.00
226.67
45.33
11.33
Utility
water
(M3/ton)
310.50
111.16
87.74
4.62
15.58
2.31
5.77
56.22
28.11
28.11
56.22
1849.62
359.17
5.97
1.79
5.97
1.49
16.19
53.98
161.95
3.00
0.60
45.33
226.67
53.98
10.80
60.00
10.00
96.00
2160.00
240.00
119.00
34.00
184.17
2.83
127.50
81.87
69.00
331.51
22.60
284.63
Overall
Water
Cons.
14.00
128.50
119.00
14.80
145.50
25.50
46.80
133.00
6.00
199.25
139.50
347 00
.
0.53
25.70
11.17
37.49
88.00
5.5
0.60
36.00
12.00
2.60
92.50
92.50
95
765.48
33.07
76.10
47.16
16.23
30.91
56.67
33.06
36.83
65.38
3.68
3.68
0.84
40.43
17.57
58.98
138.43
0.36
0.60
36.00
12.00
2.60
33.10
33.10
226.00
59.8
9.40
5.80
18.00
Sr.
No.
Name of
the
company
97.
U74
98.
99.
100.
101.
U77
U80
U79
U78
102.
U82
103.
104.
105.
U83
U84
U84
106.
U81
107.
U85
Drugs
Amox cillin
7-ADCA
Ce halexin
Diethyl. Carbamazine
Valethamate Bromide
Frusemide
Gl benclamide
Mebendazole
Ci rofloxacin
Famotidine
Lithium Carbonate
Clo ido rel
Re a linide
Fluconazole
Mosapride
Sparfloxacin
Lamotrigine
Rofecoxib
Ormeloxifen
Sibutramine
Rosi litazole
Esomeprazole
Setraline HCL
Nicorandil
Omeprazote
H drochlorthiazide
Metronidazole
Dimetronidazole
Sultamicillin Tos late
Secnidazote
Meloxicam
Biso rolol Fumerate
Flutamide
Nalidixic Acid
Metronidazole
Dictofenac Sodium
Nifedipine
Buclizine HCl
Centrizine HCl
H drox zine HCl
Meclizine HCl
Domperidone Et its
derivative
Actual
Production
(MT/ Year)
84.00
72.00
96.00
70.00
0.90
4.18
0.12
8.20
0.25
0.17
3.86
0.85
0.00
0.24
0.21
0.08
0.17
0.61
0.08
0.03
0.09
0.27
0.15
0.12
0.02
13.81
268.90
53.59
213.00
4.18
0.56
0.10
0.91
144.00
120.00
465.00
1.00
0.99
1.35
1.70
1.57
60.00
Process
Water
Cons.
M 3 / ton
28.33
28.33
14.17
1.38
377.78
488.04
17000.00
256.95
1075.10
6839.08
844.72
1943.43
1938000.00
1600.42
7103.86
21560.98
2358.38
2954.10
33412.35
11962.96
13244.19
894.74
5563.64
1600.00
20400.00
141.32
188.40
67.51
1.12
141.53
177.02
572.28
11.21
65.17
170.00
51.18
3400.00
54.95
40.30
32.00
34.65
85.00
Utility
water
(M31 ton)
31.94
27.38
36.51
2.97
76.66
449.94
12.49
883.08
81.66
56.16
1247.19
272.74
0.32
77.14
6681.81
26.47
55.84
196.89
26.14
8.71
27.76
85.86
49.71
38.41
6.46
3.23
62.93
12.54
49.85
0.98
0.13
0.02
0.21
75.71
129.38
40.62
0.09
353.72
482.35
607.41
560.96
63.25
Overall
Water
Cons.
M3/Da
75.00
0.72
6.40
169.00
367.00
347.00
63.40
110.00
200.00
70.00
30.00
Sr.
No.
Name of
the
company
108.
U86
109.
U87
110.
U88
Drugs
Actual
Production
(MT/ Year)
Ci rofloxacin
Enrofloxacin
Ac clovir
Niacin
Niacinamide
Ranitidine
Clarithromycin
Dextropropoxyphene
HCl
Dextromethorphan
Hydrobomide
Ca tro it
Az throm cin
S afloxacin
Dextromethorpham
Na s late
Cefuroxime Axetil
Ceftriaxone Sodium
Cefatoxim Sodium
Di henh dramine
Not Manufacturing Bulk
Drugs
Not Manufacturing Bulk
Drugs
-
111.
112.
U89
U92
113.
U93
Utility
water
(M3/ ton)
144.00
72.00
18.00
300.00
360.00
1.45
Process
Water
Cons.
M 3 /ton
51.94
57.61
30.22
5.67
1.89
0.94
80.06
254.80
62.60
31.30
7.82
3.85
4.62
6.87
0.00
378.36
35.51
59.56
167.81
1.32
0.03
1.83
1.52
30.07
609.66
1.67
359.08
6.25
0.14
8.65
7.16
13.60
1.32
3.24
0.43
37.95
0.28
0.69
0.09
10.00
97
Overall
Water
Cons.
(M 3 IDa y)
118.80
8.50
450.00
1.42
NAME AND ADDRESS OF BULK DRUG INDUSTRIES IN INDIA

ANDHRA PRADESH
1.
3.
Andhra Sugars Ltd.,

Post Box No. 2, Venkataraya Puram,
Tanuku - 534 211, Andhra Pradesh.
2.
Aurobindo Pharma Ltd.,
4.
Aurobindo Pharma Ltd. (Unit-()(formerly

Sri Chakra Remedies Ltd.,)
Sy No.388/389,Borapatta (V),
Hatnoor(M), Medak Dist

Patancheru, Dist: Medak,.
Andhra Pradesh.
6.
Agni Labs (P) Ltd.

B-5/1, Industrial Estate,
Sanathnagar, Hyderabad
8.
American Remedies Ltd.,

PlotNo.15, Ida, Balanagar, Rr-Ii
10. Aswini Biopharma Limited,

IDA, Gajulamandyam, Chittoor Dist.
Plot No-2, HUDA, Maitrivihar Complex,

Sanjeeva Reddy Nagar, Hyderabad-500038.
Sy No.388/389,Borapatla (V),
Hatnoor (M), Medak Dist
Andhra Pradesh.
5.
7.
9.
(Unit - V) Pashamylaram,
Patancheru, Medak (D)
Aruna Laboratories Pvt.Ltd.,
Plot No.18/B, Phase- III,

IDA, Jeedimetla, R.R.Dist.
11. Arandy Labs Ltd.,

Bollaram, Jinnaram (M), Medak (D)
12. Bell Remedies,

44, Nagarjuna Hills, Hyderabad - 500 482..
13. Bio-tech Pharma Pvt. Ltd.,

Gaddapotharam, Medak (D)
14. Biological E Ltd.,

18/3, Azamabad, Hyderabad - 500 020.
15. Cheminor Drugs (P) Ltd.,

7-1-27, Ameerpet,
Hyderabad - 500 016.
16. Cheminor Drugs Ltd.,

Sy.No.41, Bachepally(V),
Qutubullapur (M), Rr-Ii
17. Chandak Laboratories Pvt Ltd.,

Sy.No.608, 610,Kondamadugu-V,
Bibinagar-M
18. Curie Organics Pvt. Ltd.,

Sy.No.167 & 168 Bollaram,
Near Miyapur, Medak (D)
19. Cirex Pharmaceuticals Pvt. Ltd.,
20. Deccan Drugs Ltd.,

Patighanpur, Medak -502300
Survey No. 371, Gundlamachnoor Village,

Hathnoora Mandal, Medak District,
21. Dr. Reddy's Laboratories Ltd.,
(Unit - V) Peddadevulapally (V),
Tripuraram(M)
22. Dr. Reddy's Laboratories Ltd.,

7-1-27 Ameerpet, (Near Hotel Green Park),
Hyderabad-500 016.
23. Dymes Chemicals Et Pharmaceuticals Ltd.,

Plot Nos..38,39,50 Et 51, Phase - IV, IDA,
Jeedimetia, R.R.Dist
24. Dolphin Drugs Pvt. Ltd.,

C10, Madhuranagar,
Hyderabad - 500 038
25. Doctors Organic Chemicals Ltd.,

K.Illindalaparrau,-534217 Iragavaram (M),
West Godavari (D
27. Fine Drugs t Chemicals Ltd.,
6-3-788/28, Durga Nagar,
Ameerpet, Hyderabad - 500 016
26. Everest Remedies Pvt Ltd.,

Bollaram (V), Medak (D)
28. Gospadhi Chemical Industries Ltd.
le, Dawaleshwaram, East Godavari District
98
Contd.......
29. Godavari Drugs Ltd.,

1-8-303/34, Mayfair Sardar Patel Road,
Secunderabad - 500 003. (AP)
30. Globe Organics Ltd.,

7/1/27, Ameerpet,
Hyderabad-500 016.
31. Global Drugs Pvt. Ltd..

639, Temple Road, s
Bonthapally, Medak
32. Global Bulk Drugs tt Fine Chemicals Ltd.,

Digwal (V), Kohir (M), Medak Dist.
33. Hetero Drugs Ltd.,

"Hetero House", 8-3-166/4/1,
Deccan Chambers, 2 d Floor, Erragadda,
Hyderabad -500 018.
34. Heren Drugs P. Ltd.,

S. No. 1, Gaddapotharam Village,
Jinaram Mandal, Dist. Medak,
Andhrapradesh.
35. Hetero Labs Limited,

Survey No. 10, Gaddapotharam,
Jinnaram Mandal, Dist: Medak,
36. Hetero Drugs Limited,

Bonthapatty, Jinnaram Mandat,
Dist. Medak, Andhra Pradesh.
37. Hetero Drugs Ltd.,

Unitill (Formerly known as M/s. T.T.K
Pharma Ltd.,), 22-110, Ida, Jeedimetla
38. Hy-Gro Chemicals Pvt. Ltd.,

Plot No. 174, Ida, Bollaram
39. Hyderabad Drug Intermediate,

201, Sarala Apartment, 2 nd Floor,
Sanjeevreddy Nagar, Hyderabad 500 038.
40. Hyderabad Drug Intermediate Pvt Ltd.,

Plot No. 49 ft 210, Ida Pashamylram,
41. Inventa Chemical (P) Ltd.,

IDA, Jeedimetla,
Dist. Ranga Reddy, Andhra Pradesh.
42. Inventa Chemical Ltd.,

Keesara (V), Kanchikacherla (M),
Krishna Dist.
43. Inventa Chemicals Pvt. Ltd.,

F-11, A, B B. F-13 B,
IDA Jeedimetla, Hyderabad,
Andhra Pradesh 500 055.
44. IEC Chemi Tech Pvt. Ltd.,

6-3-628/19, Ravindranagar, Kairatabad,
Hyderabad 500 004
45. Impex India,

8-2-333/14-A, Road No. 3,
Banjara Hills, Hyderabad 500 034.
46. Krishna Alchemy Pvt.Ltd.

172/A, 116, Ida Boltaram, Medak (D)
47. Krebs Biochemicals Ltd.,

Kothapalli Village, Kasimkota Mandal,
Dist: Vishakhapatnam,
48. Krebs Biochemicals Ltd.,

Kodavalur (Mandal),
Dist: Nellore,
49. Kopalle Pharma Chemicals Pvt. Ltd.

Piot No D133, Phase-Iii ,Ida,
Jeedimetla, Hyderabad.
50. Monarch Laboratories Ltd.,

6-3-1690/C/4, Rajbhavan Road,
Hyderabad 500 082
51. Matrix Laboratories Ltd., (Formerly known

as Herren Drugs And Pharmaceuticals Ltd.),
Unit -I, Sy.No.10, Gaddapotharam,
Jinnaram (M), Medak
52. Nakoda Chemicals Pvt. Ltd.,

D-30, Phase-I, I.D.A., Jeedimetla,
Hyderabad 500 855.
53. Neuland Laboratories Ltd.,

Veera Bhadra Swamy Temple Road,
Bonthapalty (V),Jinnaram (M), Medak Dist.
54. Nutek Process Chemicals P. Ltd.,

Sreenilayam,Gannavaram(M), Krishna Dist.
"
99
Contd.......
55. Neulife Laboratories Ltd.,

S.No.10, Gaddapotharam (V),
Jinnaram (M), Medak (D)
56. Nakoda Chemicals Ltd.,

Plot No. 130, Phase-I, IDA, Jeedimetla,
Ranga Reddy dist.
57. Otto Meyerhof India,

D-34, Ida, Jeedimetla, Rr-Ii
58. Qure Drugs Pvt.ltd.,

Chitkul (V), Sangareddy (M), Medak (D)
59. Padmavathi Laboratories P. Ltd.

Bonthapally (V), Jinnaram (M)
60. Parke-Davis (India) Ltd.,

Warrangal Road, Uppal,
Hyderabad 500 039.
-
61. Pfimex Organics Ltd.,

4-1-1240, Kingkoti Road,
Abids, Hyderabad 500 001.
62. Plant Organics Ltd.,

S. V. Coop, Industrial Estate,
Ballaram Village, Dist. Medak,
63. Proven Chemicals Ltd.,

Gaddapotharam, Jinnaram (M)
64. Prudential Pharmaceuticals Ltd.,

Sy.No.133, IDA Bollaram, Medak (D)
65. Paks Veterinary Drugs It Mfg.co. Ltd.,

(Formerly known Paks Trade Centre),
3-72, Gadda Potharam, I.D.A,
Jinnaram (M), Medak Dist.
66. Prasad Drugs Ltd.,

Sy. No. 296/7/3, Bollaram, Narsapur Tq,
Medak Dist.
67. Premier Organics Ltd.

Mekaguda (V), Kothur (M),
Mahaboobnagar
68. Prasad Drugs Pvt. Ltd.,

8-3-214/6, 2 Floor, SBH Bldg,
Shrinivas Nagar Colony (W),
Hyderabad 500 038.
69. Pharmasia Fine Chemicals Ltd.,

Sy.No.296/7/3, Bollaram, le,
Jinnaram (M), Medak (D)
70. Rama Organics Pvt. Ltd.,

Bollaram, Medak
71. Ratna Drug Ft Chemicals Pvt.ltd.,

Ida Pashamylaram, Medak (D)
72. Ramkamal Labs,

5-403, Divyasakthi Apts.,
Ameerpet, Hyderabad 500 016
-
73. Sri Indra Pharma Chemical Products (P)

Ltd.,
Industrial Estate, Dowleswaram
74. Sreeshma Bulk Drugs Pvt. Ltd.,

S.No.13, Gaddapotharam (V),
IDA Kazipally,IA Jinnaram (M)
75. Suven Pharmaceuticals P. Ltd.,

Natco House, Road No. 2,
Banjara Hills, Hyderabad 500 033.
77. SOL Pharmaceuticals Ltd.,
5-9-88/2, Fateh Maidan,
Saphire Bldg., Hyderabad 500 001.
76. Suven Pharmaceuticals Ltd.,

Desaigudem (V), Suryapet Mandal,
Nalgonda Dist.
78. S R P Chemical Pvt. Ltd.,
S.No.174, Bottaram(V),
Narsapur, Medak (D)
79. Standard Organics Ltd.,

Plot No.36 To 44, Ida Phase
Patancheru,
80. Standard Organics Ltd.,

5-9-88/2, Saphire Building, 1s t Floor, Fateh
Maidan, Hyderabad 500 001.
81. S P S Pharma Pvt. Ltd.,

Bollaram (V), Narsapur (M),
IV,
82. Sumitra Pharmaceuticals Et Chemicals

Ltd.,
Digwal (V), Kohir (M), Medak (D)
100
Contd.......
83. Symed Labs Pvt.Ltd.,

S.No.353 Domadugu, Bonthapally,
Jinnaram (M)
84. Sigachi Laboratories Ltd.,

Sy.No.530 t 34, Bonthapally (V),
Jinnaram (M), Medak Dist.
85. S M S Pharmaceuticals Ltd.,

I.E., Kazipally (V), Jinnaram (M),
Medak Dist.
86. S.M.S. Pharmaceuticals Ltd.,

417, 4 th Floor, Aaditya Enclave,
Ameerpet, Hyderabad - 500 038.
87. Saraca Laboratories Ltd.,

Sy. No. 10, Gaddapotharam (V),
Jinnaram (M)
88. Sreepathi Pharmaceuticals Ltd.,

601, Suryakiran 92/93, S.D. Road,
Secunderabad - 500 003
89. Sri Nageswara Chemicals It Drugs P. Ltd.,

7-1-451/7, Ameerpet, Near Satyam
Theatre,
Hyderabad - 500 016
90. Sterile Specialities India (P) Ltd.,

R.S.No.168/162, Enikepadu(V),
Vijayawada(R), Krishna Dist.
91. Sri Krishna Pharmaceuticals Pvt. Ltd.,

C-4, IDA, Uppal, R.R.Distrcit - 500039
92. S. K. S. Drugs (P) Ltd.,

Bibinagar (V Fx M),
93. Srini Pharmaceuticals Ltd.,

Sy. No. 247, Choutuppa (V & M)
94. T P S Laboratories Pvt. Ltd.,

Ida, Gaddapotharam,
Narsapur (M), Medak(D)
95. Tini Laboratories P Ltd.,

Kotha Kalva, Narayana Reddypet,
Indurkurpet, Nellore Dt
96. Tini Labs P Ltd.,

17/58, Dronamaraju Vari Street,
Nellore Dt
97. United Intermediates Ft Chemicals P. Ltd.

C - 10, Madhura Nagar,
Hyderabad - 500 038
98.. Virchow Laboratories Ltd.,

Plot No.4, S.V Cooperative Ind. Estate,
IDA Jeedimetla, Hyderabad - 500 855
99. Veena Organics (P) Ltd.,

S.No.279, Phase-I, Ida, Jeedimetla, Rr-Ii
100. Vorin Labs. (P) Ltd.,

1-8-179/2, Usha Kiran, S. D. Road,
Secunderabad - 500 003, (AP).
101. Veer Chemie And Aromatics (P) Ltd.,

Plot No.A-4, Co-Oprative Industrial Estate,
Balanagar, Ranga Reddy
103. Vennam Chemicals Pvt. Ltd.,
Laxmikkapally (V), Mulugu (M),
Medak (D)
105. Vera Laboratories Ltd.,
G.Chowdavaram Village, Pusapatirega
Mandal
Vizianagaram District
107. Waksman Selman Pharmaceuticals,
296/2, Govendapalli (V), Near
Tadakaleru,
102. Vista Pharmaceuticals Ltd.,

APIIC Industrial Estate, Gopalaipalti (v),
Narketpally (M)
104. Vipla Organics Pvt.ltd.,
Bollaram (V), Narsapur (M),
Medak Dist.
106. Vera Laboratories Ltd.,
5-9-12, Samrat Complex,
1st Floor, Saifabad
Hyderabad, Andhra Pradesh - 500 004.
108. Yenkay Drugs tt Pharmaceuticals Ltd.,
8-3-903/3/A/302, Omega Apartments,
Yellareddyguda, Nagarjuna Nagar Colony,
Hyderabad - 500 016
101
Contd.......
CHANDIGARH
1.
Ind-Swift Labs Ltd.,

SCO 493-494, Sector 35-C,
Chandigarh.
2.
Max G.B. Ltd.,

S.C.I. 86-87, Sector 8-C,
Chandigarh.
3.
Surya Pharmaceuticals Ltd.,

1232, Sector 18-C,
Chandigarh - 160 018.
4.
Vikram Pharmaceuticals Pvt. Ltd.,

29, Industrial Area, Phase - I,
Chandigarh - 160 002.
DELHI
1.
Allied Chemicals t Pharmaceuticals, P.

Ltd.,
Rajnigandha Complex,
8734, Deshbandhu Gupta Road,
Pahar Ganj, New Delhi-110 055.
2.
Allana Pharmachem Ltd.,

10, Scindia House, 2n d Floor,
Connaught Circus, New Delhi-110 001.
3.
Alpine Industries,
A-67, Naraina Industrial Area,
Phase-I, New Delhi.
4.
Atul Drugs,
1706, Bhagirath Palace,
Chandni Chowk, Delhi - 110 006.
5.
Daurala Organics Ltd.,

22-B, Himalaya House, 2 nd Floor,
23, Kasturba Gandhi Marg,
New Delhi - 110 001.
6.
Emralds Pharmachem,
3rd Floor, D-138, East of Kailash,
7.
Indian Drugs Et Pharmaceuticals Ltd.,

IDPL Complex, Dundajera, Delhi-Gurgaon
Road, Gurgaon-122016.
8.
Indian Petrochemical Corpn. Ltd.,

P.O. Box-3816, New Delhi-49.
9.
Jayant Vitamins Ltd.,

12, Bhargava Lane,
Civil Lines, Delhi - 110 054.
10. Jagsonpal Pharmaceuticals Ltd.,

T-201, J. Shahpur Jat,
New Delhi - 16.
11. J K Drugs & Pharmaceuticals Ltd.,

53, Community Centre,
New Friends Colony, Mathura Road,
New Delhi - 65.
13. Maiden Pharmaceuticals Ltd.,
1594/9, 3' d Road, M.J. Bldg.,
Bhagirath Palace, Chandinichowk,
Delhi -110006
12. Morepen Labs. (P) Ltd.,

416-418, Antriksh Bhawan,
22, K. G. Marg, New Delhi - 110 01.
15. Pharma-Deals,
1541, 1 st Floor Bhagirath Palace,
Chandi Chowk, Delhi - 110 006.
16. Perfect Drugs Ltd.,

74, Hemkunt Colony,
17. Paam Drugs Et Pharma Ltd.,

26, Bhargava Lane Civil Lanes,
Nityananda marg, New Delhi-110 054.
18. Ranbaxy Laboratories Ltd.,

Devika Tower, 11 th Floor,
6, Nehru Place, New Delhi - 110 019.
19. Sree Krishna Pharmaceuticals,

12, Bhargava Lane,
Civil Lines, Delhi - 110 054.
20. S. M. Organics Pvt. Ltd.,

30, Hanuman Lane,
Connaught Place, New Delhi -110 001.
14. Panacea Biotech Ltd.,

102, Ashok Plaza,
24, School Lane, New Delhi-110 001.
102
Contd.......
GUJARAT
1.
Aashi Industries Ltd.,

310-311, Mahakant Building,
Opp. V.S. Hospital, Ellis Bridge,
Ahmedabad 380 006.
2.
Atul Products Ltd.,

Ashoka Chambers, Mithakhali Ellisbridge,
Ahmedabad, Gujarat.
Aditya Chemicals
240, Kalpana Complex, Near Memnagar
4.
Cadila Chemicals Ltd.,

244, Ghodsar, Maninagar,
Ahmedabad-380 008.
Cadila Healthcare Ltd.

Zydus Tower, Satellite Cross Road,
Sarkhej Gandhinagar Highway,
Ahmedabad 380 015. (Gujarat)
6.
Dart Drug Pvt. Ltd.,

Ashoka Chambers, II Fir.,
Mithankhati "X" Roads,
Ahmedabad 6
Concord Pharmaceuticals Ltd.,

1482-1486 Trasad Road,
Dholka- 387 810. Dist. Ahmedabad.
8.
Suchem Laboratories,
Post Box No. 55, 10/13, Phase
GIDC Indl. Estate, Vatva,
Ahmedabad 382 445
10. Swati Chemicals,

624, Phase IV, GIDC Vatwa,
Dist: Ahmedabad,
Gujarat 382 445.
3.
Fire Station, Navrangpura, Ahmedabad-009

5.
7.
9.
I,
Ishita Pharmaceuticals,
11,Valmik, 3r d Floor, Near Parimal Garden,
Ahmedabad 380 006.
-
11. Torrent Labs. Ltd.,

Torrent House, Near Dinesh Halt,
Ashram Road, Ahmedabad 380 009.
12. Zora Pharma (P) Ltd.,

604, Aniket, C.U. Road,
Navrangpura, Ahmedabad-380 009.
13. Alembic Chemicals Works Co. Ltd.,

Alembic Road, Vadodara- 3.
14. Ambalal Sarabhai Enterprises Ltd.,

P. 0. Box No.31, Wadi Wadi,
Baroda 390 007 Gujarat.
15. Bio-Pharma,
18/A, 406, World Trade Centre,
Sayajigunj, Vadodara 390 005.
16. Century Pharmaceuticals Ltd.,

(Century Pharma Pvt. Ltd.)
406, World Trade Centre,
Sayajigunj, Vadodara 390005.
17. Canberra Chemicals,

C-1, 91/7, GIDC, Nandesari
Vadodara, Gujarat.
18. Darshak Ltd.,

Mezannine Floor, Near Admn. Bldg.,
Alembic Road,Baroda 390 003,
391 340.
19. Dishman Pharmaceuticals Ft Chemicals

Ltd.,
Survey No. 48, Paiki, Subplot No. 1,
Village: Lodariya, Taluka: Sanand,
Dist: Ahmedabad, Gujarat- 380 009.
20. Dishman Pharmaceuticals 8t Chemicals

Ltd.,
1216/20, GIDC Phase IV, Naroda,
Ahmedabad, Gujarat- 382 330.
21. Dinesh Pharmaceuticals Pvt. Ltd.,

Yamuna Kunj, Mahavir Colony,
Rajmahal Road, Vadodara 390 001.
22. Hemko Chemical Industries,

4\13, Industrial Estate,
Gorwa, Vadodara 390 016
23. Jayant Oil Mills,

480-82, GIDC, Makarpura,
Vadodara 390 010.
24. Kailash Pharmaceuticals Pvt. Ltd.,

24, Bhagya Laxmi Society,
Refinery Road, Gorwa,
Vadodara 390 016
103
Contd.......
25. Mangalam Drugs Et Organics Ltd.,

Plot No. 1203, GIDC Vapi,
Dist: Valsad, Gujarat.
26. S. G. Pharmaceuticals,
Market Planning Department,
SMC Admn Building, Gorwa Road,
Baroda-390 007.
27. Torrent Gujarat Biotech Ltd.,

At. Masar, Tal. Padra,
Dist. Vadodara, Gujarat.
28. Unimark Remedies Ltd.,

337, Kerala Nalsarovar Road,
Bavla, Dist: Ahmedabad,
29. Vipor Chemicals Pvt. Ltd.,

301, Ivory Terrace,
R. C. Dutt Road, Baroda 390 005.
30. Vitara Chemicals Ltd.,

Plot No. 163/164, G.I.D.C. Estate,
Nandesari 391 340, Gujarat.
31. Abott Laboratories (I) Ltd.,

3203, GIDC Industrial Area,
Ankleshywar, Dist. Bharuch-393 002
32. Aventis Crop Science Ltd.

Plot No. 6301-10A, GIDC, Ind. Estate,
P.B. No. 136, Ankleshwar 393 002.
33. Cadila Laboratories Pvt. Ltd.,

Plot No. 294, G.I.D.C. Estate,
Ank.leshwar-390 002.
34. J. B.Chemicals tt Pharmaceuticals Pvt.

Ltd.,
Plot No. 215 -218, Panoli Industrial Estate,
GIDC Panoli, Dist: Bharuch, Gujarat.
35. K. A. Malle Pharmaceuticals,

Plot No. 6005, GIDC, Ankleshwar,
Dist. Bharuch, Gujarat.
36. Mirabh Pharmaceuticals Pvt. Ltd.

40, GIDC, Chitra,
Bhavnagar 364 004
37. Xylon Laboratories,

C-1/10, GIDC, Nadiad
Gujarat.
38. Parth Laboratories P. Ltd.,

C-1B,
Phase-11,
270,
GIDC
Industrial Estate, Rajkot-360 003.
39.
387 001.
Pharma Chem Laboratories,

Rshtriyashalal Marg,
Rajkot 360 002
Estate,
40. Avik Pharmaceuticals Pvt. Ltd.,

A-1 /7, GIDC,
Vapi-396 195 (Gujarat).
41. Ashtel Laboratories Ltd.,

C-1, B-76, 100 Shed Area,
GIDC Vapi, Gujarat- 396 195.
42. British Pharmaceuticals Laboratories,

Plot No. 39, G.I.D.C. Estate,
Phase-I, Vapi 396 195.
43. Themis Medicare Ltd.,

Plot No. 69/A, GIDC Vapi,
Vapi, Gujarat 396 195.
44. Unimark Remedies Ltd.,

41. GIDC Vapi, 1s t Phase,
Vapi, Gujarat 396 195.
JHARKHAND
1. Jayne Pharmochem Pvt. Ltd.
Sirtdo, Industrial Estate,
Mesra, Ranchi - 835 215
KARNATAKA
1. Anglo-French Drug Co. (Eastern) Ltd.,
41, 3 rd Cross, V. Block, SSI Area,
Rajajinagar, Banglore - 560 010.
2. Arvee Chem Pharma Pvt. Ltd.,

18/B, Industrial Suburb,
III Stage, Vishwevarnagar,
Mysore South, Mysore - 570 008.
104
Contd.......
3.
Astra-IDL Ltd.,
32/1-2, Crescent Road,
Bangalore 1.
4.
Jupiter Organic Pvt. Ltd.,

24, Kolar, Bidar 563 005.
Karnataka.
6.
Pharmasia Ltd.,
49, Bhel Enclave, Akbar Road,
Secunderabad 500 009.
8.
Smithkline Beechem Pharmaceuticals

(India) Ltd.,
107-109, Belagola Industrial Area, Meta
Galli, Mysore 570 016, (KA).
10. Sri Parameshwari Chemical Industries

Plot No 20-21, Seshadri Rd, Bangalore
5.
7.
Kothari Phytochemicals International,

465, K.K. Nagar,
Mudurai 625 020.
-
9.
Eskayef Ltd.
107-109, Belagola Indl. Estate,
Metagalli, Mysore 570 016.
R. L Fine Chem.,
C-14, KSSIDC Industrial Estate,
Yelahanka, Bangalore 560 064.
-
KERALA
1.
Chackosons Chemicals Pvt. Ltd.,

Mulakunnathukavu P.O.
Dist. Trichur, Kerala 680 581.
2.
3.
Malabar Organics Ltd.

X 86 P.O. Moodadi, Quilandy,
Calicut 673 325, Kerala
-
Sangrose Laboratories P. Ltd.,

Industrial estate, Kollakadavu, Kallimel
P.O, Mavelikara, Alappuzha (Dist),
Kerala 690 570
-
MAHARASHTRA
1.
Aarey Drugs Ft Pharmaceuticals Ltd.,

103/7,Sahakar Bhavan, 340/48,
Narsinadha Street, Mumbai-400 009.
2.
3.
Aviditya Chemicals Et Pharmaceuticals,

MIDC, Plot No.: 40, Morivali Section,
Ambernath, Dist. Thane, Maharashtra
4.
Acharya Chemicals,
Jawahar Wadi, Manpada Road, Dambioli,
Dist. Thane, Maharashtra
5.
Armour Chemicals,
54-A, M. Vasanji Road, Opp. Sangam
Theatre, Anheri (E), Mumbai 400 093.
6.
Alkyl Amines Chem Ltd.,

207-A,Kakad Chambers, 132,
Dr, Annie Besant Road, Worali,
Mumbai-400 018.
7.
Alta Labs. Ltd.,

Alta Bhavan, 532, Senapat Bapat Marg,
Dadar, Mumbai-400 028.
8.
Amol Drug Pharma Ltd.,

Fatima Big., 3,Mogul Lane, B/H Johnson Et
Johnson, Mahim (W), Mumbai-400 016.
9.
Abhi Chemicals Et Pharmaceuticals Ltd.,

MIDC Plot No, T-37 Et T-38,
Bhosari Industrial Estate, Pune-411 026.
10. Ashok Organic Industries Ltd.,

406, Sharda Chambers,33,
Sir Vithaldas Thackerey Marg,
New Marine Lines, Mumbai 400 020.
12. Avik Pharmaceuticals Ltd.,
194, Arvind Chambers, 27, Ground Floor,
Western Express Highway,
Andheri (E), Mumbai-400 069.
Aarti Drugs Pvt. Ltd.,

18-A Krishna Niwas, Road No.1,
Scheme No. 6, Sion (East), Mumbai
022.
11. Arbitee Chem Pharma,

Clark House,
8, Wood House Road,
Mumbai 400 039.
-
105
Contd.......
13. Ajanta Pharma Ltd.,

98, Govt. Industrial Estate, Charkop,
Kandivli (W), Mumbai 400 067.
14. Apte Amalgamations Ltd.,

J-7/8/9, M.I.D.0 Industrial Area, Taloja,
Tal. Panvel, Dist. Raigad, Maharashtra
15. Bajaj Organic Ltd.,

103, Yogeshwar 135/139,
Kazi sayeed Street, Mumbai-400 003.
16. BDH Pharmaceuticals Ltd.,

602/B, Poonam Chambers, 'A', Shivsagar
Estate, Worli, Mumbai 400 018.
17. Bakut Aromatics t Chemicals Ltd.,

Sterling Centre, 4` h Floor,16/2,
Dr. Annie Basant Road,
Worli, Mumbai 400 018.
18. Bayer (I) Ltd.,

Bayer House,
Central Avenue, Hiranandani Garden,
Powai, Mumbai 400 076.
19. BASF India Ltd.,

Rhone Poulenc House, Sodam Kalu Ahire
Marg, Mumbai 400 025.
20. Biddle Sawyer,

Das Chamber, 25, Dalal Street,
Fort, Mumbai 400 023.
21. Bombay Chlorides Pvt. Ltd.,

Plot No: W-72B, MIDC, Badalapur,
Dist. Thane 421 503
22. Bharat Chemicals,

74, Matru Suruti, 2 nd floor, Road No: 4,
Scheme No: 6, Sion (E), Mumbai 400 022.
23. Bimal Pharma Chem,

1/D-12, Indraprastha, Raheja Township,
Jitendra Road, Malad (E), Mumbai,
Maharashtra 400 097.
24. Bajaj Healthcare Pvt. Ltd.

14\15, Faiz-E-Edros, 1 st Floor,
371\373, Narsi Natha Street,
Mumbai 400 009
25. Bakul Aromatics Et Chemicals Ltd.,

A/6, MIDC Patalganga,
Patalganga Industrial Area,
Kaire, Dist: Raigad,
26. Bajaj Organics Ltd.,

103, Yogeshwar, 1 st Floor,
135/1369, Kazi Syed Street,
Masjid, Mumbai,
27. BDH Group of Companies,

Nair Baug, Akurli Road,
Kandivali (E), Mumbai 400 101.
28. Bombay Paxwell Pharmaceutical P. Ltd.,

Metalage Industrial Compound, Subhash
Road, Jogeswari (East), Mumbai-400 060.
29. Boehringer Mannheim (India) Ltd.,

CenterPoint, Dr. Ambedkar Road, Opp.
Bharathi Matha Theatre, Mumbai 12.
30. Biochem Industries,

'A' Aidun Building, 5 th Floor,
15t Dhobi Jalao, P. 0. Box
2217,
Mumbai 2.
31. Burroughs Wellcome (I) Ltd.,

252, Dr. Annie Besant Road, Worli,
Mumbai 400 025.
32. Cipla Ltd.,

289, J.B.B. Marg,
Mumbai Central, Mumbai 8.
33. Chemical Supply Corpn.

Lotlikar Bldg.,Ground Floor,
5/21, Ropa Lane, Chandan Wadi,
Mumbai 400 002.
34. Chemphar Organics (I) Pvt. Ltd.,

K-47, M.i.D.C. Estate,
Tarapur Industrial Area,
Boisar, Thane 401 501.
35. Chemfine,
210, Maker Bhavan III,
21, New Marine Lines, Mumbai 400 020
36. Chemo Pharma Laboratories Ltd.,

Empire House, 214, Dr. D.N. Road,
Fort, Mumbai 400 001
37. Catapharma Chemicals Pvt. Ltd.,

28, Trimbak, Shahu Maharaj Path
Nasik Road 422 101
38. Chemox Group of Companies,
317, Poonam Asha Building,

Narsi Natha Street, Mumbai 400 009
-
106
Contd.......
39. Chemo Research Labs Pvt. Ltd.

Datamal House, IV Fl000r,
206, Backbay Reclamation, Nariman Point
Mumbai - 400 021
40. Calyx Chemicals & Pharmaceuticals Pvt.

Ltd.,
Unit No: 2, Marwah Industry House, Saki
Vihar Road, Sakinaka, Mumbai - 400 072.
41. Citric India Ltd.,

Empire House Illyd Floor,
Dr. D.N. Road, Fort Mumbai - 400 001
42. M/s. D.K. Pharma Chem Pvt. Ltd.,

F - 32 / W - 6, MIDC, Badlapur - 421 503.
43. Dharamsi Morarji Chemical Co. Ltd.,

317/21 Prospect Chambers,
Dr. D.N. Road, Mumbai - 400 001.
44. Dishman Pharmaceuticals t Chemicals,

401, The Sangeet Plaza,
Marot Maroshi road, Andheri (E),
Mumbai - 400 059.
45. Duphar Interfran Ltd.,

F-5, Shivsagar Estate,
Dr. Anni Besan Road, Worli, Mumbai - 18.
46. Euresian Ethachem,

112, Marine Chambers,
11, New Marine Lines, Mumbai - 400 020.
47. Emmellen Biotech Pharma Ltd.,

A.Block 4/C, 303 Et 304, 3 rd Floor, Damodar
Park, Ghatkopar (W), Mumbai - 400 086.
48. Eastern Chemicals Industries,

J. K. Building, Daugal Road,
Ballard Estate, Mumbai - 400 001.
49. Eupharma Laboratories Ltd.,

Sahakar Marg., Vile-Parle(E),
Mumbai - 400 057
50. Eagle Pharmaceutical Works,

114, Belgrami Road,
Match Factory Lane, Kurla, Mumbai
51. Euro Asian Industrial Company,

G.P.O. Box No. 1398,
Fort, Mumbai, Maharashtra - 400 001.
52. Elder Pharma Ltd.,

11-B, Dhamaj Mahal,
Apollo Bunder, Mumbai.
53. Eskay Fine Chemicals,

Mehta Mahal, Ground Floor, 15 Mathew
Road, Opera House, Mumbai - 400 004.
54. E. Merck (India) Ltd.,

A, Shivasagar Estate,
Anni Besant Road, Worli, Mumbai-18.
55. Euro Asian Industries,

16/2, Nadirsha Sukhia Street,
Banu Mansion, Fort, Mumbai - 400 001.
56. Elder Projects Ltd.,

232, G.I.0 Building, D.N. Road,
Bombay - 400 001
58. FDC Ltd.,

57. Franco- Indian Pharmaceuticals Ltd.,
20, Dr. E. Moses Road, Mumbai -400011. Plot No. 19.20, MIDC, Dhatao,
Roha-402109.
59. Fern Care Pharma Ltd.,
Fern House, Ram Mandir Road,
Kherwadi, Bandra (E), Mumbai - 400 051.
60. Fine Chemicals

(Division of Super Fine Labs (P) Ltd.)
50, Peerbhyo Mansion, 89,
Princes Street, Mumbai - 400 002
61. German Remedies Ltd.,

Shivsagar Estate, À' Block,
Dr. A. B. Road, Worli, Mumbai - 400 018.
62. Glaxo (India) Ltd.,

Dr. Anni Besant Road, Worli, Mumbai-25.
63. Gayatri Labs. (P) Ltd.,

26/3, Jay Mahal Estate,Kitchen Garden
Lane, Princess Street, P. B. No. 2273,
Mumbai - 2.
64. G. Amphray Laboratories,

Bell Bldg., 4 th Floor,
Sir P.M. Road, Mumbai - 400 001.
107
Contd.......
65. Gujarat Lyka Organics Ltd.,

Acme Plaza, Andhra-Kuria Road,
Andheri (E), Mumbai 400 059.
66. Gufic Chem Pvt. Ltd.,

Subhash Road, À' Vile Parle (E),
Mumbai 400 037.
67. Hindustan Antibiotics Ltd.,

Mumbai Pune Road, Pimpri,
Pune- 411 018, Maharashtra.
68. Herbert Brown Pharmaceutical Et

Research Laboratories,
W-258-A, MIDC, Phase-II, Shivaji Udyog
Nagar, Dombivli (E) 421 203. Dist. Thane.
69. Harman Finochem Ltd.,

107, Vinay Bhavya Complex, 1 5t Floor,
159-A, Ashoka Steel Chain Compound,
C.S.T. Road, Kalina, Mumbai 18.
70. Haffkine Biopharmaceutical Corpn. Ltd.,

Achary Donde Marg,
Parel, Mumbai-12.
71. Hoechst Marion Roussel Ltd.,

Hoechst House, 54/A, Sir M. Vassanji Road,
Andheri (E), Mumbai-93.
72. Indosol Drugs Pvt. Ltd.,

Wadia Buildinh, 1s t Floor,
22/D, S.A. Brelvi Road, Fort, Mumbai-01
73. Indo German Alkaloids,

Mahakali Road, Andheri (E),
Mumbai, Maharashtra 400 093.
74. IPCA Laboratories Ltd.,

63-E, Epka House, Kandivali Industrial
Estate, Kandivali (W), Mumbai-67.
75. J.P. Pharmachem Industries,

B/12, Atka, Opp. N.L.H.S.S.V. Road,
Malad (W), Mumbai,
Maharashtra.
76. J.B.Chemicals ft Pharmaceuticals Pvt.

Ltd.,
Plot No. P-10 Et 10-P, Shiv Mahape,
P.O.Gansoli, Dist: Thane, Maharashtra.
77. J. B. Chemicals t Pharmaceuticals Ltd.,

4` h Floor, `B' Wing, Neelam Centre, Hind
Cycle Road, Worli, Mumbai-400 025.
78. M/s KDL Biotech Ltd.,

Parjgat House, 1076, Dr. E. Moses Road,
Worli, Mumbai 18.
79. Kores (India) Ltd.,

1St Pokhran Road, Thane (W) -400606
80. King Industries,

504, Popatlal Chambers, V Floor,
4` h Clive Cross Lane,
Dana Bunder, Mumbai 400 009
81. Kebee Pharmachemie (P) Ltd.,

506, Raheja Chambers, 213, Nariman Point,
Mumbai -400021.
82. Kopran Ltd.,

1076, Dr. E. Moses Road,
Worli, Mumbai -400018.
83. Kubo Combustion Efficiency Chemicals

Pvt. Ltd.
401, Amit Industrial Estate,
61, Dr. S.S. Rao Road, Parel,
Mumbai 400 012
84. Laboratory t Industrial Chemical

Corporation,
660/3, Y.P. Powar Nagar,
Kolahapur 416 012
85. Lubcut Indocorporation

B\8, Nand Dham, Marol,
Mumbai 400 059
86. Lyka Laboratories,

77, Nehru Road, Vile Parl (East),
Mumbai -400099.
87. M.J. Pharmaceuticals Ltd.,

3, Narayan Building, 23 LN RD,
Dadar (E), Mumbai-400 014.
88. Magnum Intermediates Ltd.,

N-175, M.I.D.C., Tarapur, Thane.
108
Contd.......
89. MAC Laboratories Pvt. Ltd.,

Kirol, Vidyavihar,
Mumbai - 400 086.
91. Medinex Laboratories (P) Ltd.,
1, Prabhat Nagar, Togeshwari (W),
Mumbai-400 102.
90. Mehta Pharmaceuticals Industries,

315-318, Janaki Centre, Plot No. 29,
Shah Industrial Estate, Veeradesai Road,
Mumbai - 400058.
92. Maharashtra Antibiotics &
Pharmaceuticals Ltd.,
L- 1,MIDC Area,Hingna Rd,
Nagpur - 440 016.
93. Merind Ltd.,

Wockhardt Towers, C/3-G Block, BandraKuria Complex, Bandra (E),
Mumbai-400 501.
94. M/s. Makers Laboratories Ltd.,

A - 163, Phase - I, M.I.D.0 Pambioli (E),
Dist. Thane - 421 203.
95. Nandlal Bankatlal Pvt. Ltd.,

206, Sharaf Mansion, 32, Princess Street,
Mumbai - 400 002
96. Nitson Laboratories,

1003, Raheja Centre, 214,
Nariman Point, Mumbai - 400 021
97. Nivedita Chemicals Pvt. Ltd.,

A-14, MIDC, Andheri (E),
Mumbai - 400 093.
98. Nicholas Piramal (India) Ltd.,

Sion-Trombay Road,
Deonar, Mumbai - 400 088.
99. Nem Organics Ltd.,

162, Senapati Bapat Marg,
Opp. Phoenix Mills,
Lower Patel, Mumbai - 400 002.
100. Novartis India Ltd.,

L-1, Additional MIDC, Mahad, Dist. Raigad,
Maharashtra - 402 301.
101.
Natural Vitamins Pvt. Ltd.

42\44-A, Babu Genu Road,
2" Floor, Princes Street, Mumbai - 002
102. Pfizer Ltd.,

Pfizer Centre, Patel Estate, Off. S.V.
Road, Jogeshwari (West), Mumbai- 102.
103.
Pharmica,
Mahendra Mension, 3 rd Floor, 28,
Babu Genu Road, Mumbai - 400 002.
104. Piramal Healthcare Ltd.,

100, Centre Point, Dr. Babasaheb
Ambedkar Road, Parel, P. 0. Box No.
6011, Mumbai - 12.
105.
Prati Chem,
Plot No: 51, Sector 2,
Vasai Taluka Indl. Estate, Vasai (E),
Dist. Thane - 401 208.
106. Prerna Pharma Intermediates Pvt. Ltd.,

Plot No: 57, MIDC, Morivali,
Ambernath - 421 501.
107.
Ropa Laboratories Pvt. Ltd.,

211, Datamal Chambers, 29, New Marine
Lines, Mumbai -400020
108. Rallis India Ltd.,

21, Rallis House, D.S. Marg,
Mumbai -400001.
109.
Raigad Pharmaceuticals Pvt. Ltd.,

Plot No. 9, 'Abit', 2 Floor,
Jaibharat HSG. SOC. Ltd.,
3 rd Road, Khar (W), Mumbai - 400 052
110. Rupal Chemical Industries Ltd.,

(Division of Aarti Industries)
18-A, Krishna Niwas, Road No:1,
Scheme 6, Sion (E), Mumbai - 400 022
111.
Raw Pharma,
2, Aidun Building, 'B' Ground Floor,
1 5f Dhobi Talao Lane, Mumbai-400002.
112. Raptakos, Brett t Co. Ltd.,

Dr. Annie Besant Road, Worli,
Mumbai 400 025.
109
Contd.......
113. Smruthi Orgnaics Ltd.,

165-1 Balaji Bhavan, 1St Floor,
Railway Lines,
Solapur - 413 001, Maharashtra.
114. Sunrise Drugs t Chemicals Industrial

Estate,
307, Doctor House, 14, Poddar Road,
Opp Jasfok Hospital, Mumbai - 400 026
115. Samantha Organics (P) Ltd.,

149, Arvind Chambers, Off. Western
Express Highway, Andheri (E),
Mumbai - 400 069.
116. S. D. Fine Chem ltd.,

315-317, T. V. Industrial Estate, 248,
Worli Road, P.B.No. 19160, Worli, Mumbai
-25.
117. Shrivin Drugs tt Pharma Pvt. Ltd.,

509, Himalaya House, Patton Road,
Mumbai - 400 001.
118. Shrenik Pharmaceuticals Pvt. Ltd.,

5, Pankaj Mahal Dinsha Wacha Road,
Church Gate, Mumbai-400020.
119. Somaiya Organo Chemicals Ltd.,

45/47, 4 th Floor, Fazalbhoy Building,
Fort, Mumbai -400023.
120. Sekhsaria Chemicals Pvt. Ltd.,

11-A, Mittal Chambers,
Nariman Point, Mumbai - 400 021.
121. Syntho Rifa Pvt. Ltd.

B - 35, Mangaldas Bldg. No: 1,
2n d Floor, 13, Mangaldas RD.,
Princess Street, Mumbai - 400 002
122. Synthola Chemicals ft Research

20\30 Shaml Das Gandhi Marg,
Mutchand Mansion, 1 St Floor,
Room No.2, Princess Street,
Mumbai-400002
124. Shreya Health Care Pvt. Ltd.,
113, Jolly Maker Chambers No:2,
Nariman Point, Mumbai -400021.
123.
Sandoz (India) Ltd.,
Sandoz House, Dr. Annie Besant Road,

Worli, P.O. Box: 6596, Mumbai - 018
125. Syntholab Chemicals ft Researches
Units,
19/20, Prem Industrial Estate, Subhash

Road, Jogeshwari (East),
Mumbai - 400 102.
126. Samarpan Pharmaceuticals Pvt. Ltd.,

Plot No: 68, MIDC Area, Chikhldi,
Ambernath - 421 505.
127. Smruthi Organics Ltd.,

Unit I, Plot No. 273 & 274,
Akkalkor Road, Solapur, Maharashtra
128. Smruthi Organics Ltd.,

Unit II, Plot No. A-27, MIDC Chincholi,
Tal: Mohol, Dist: Solapur,
Maharashtra-413255.
129. S.S Pharmachem,

D - 1/301, Jumbo Darshan, Andheri
(East), Mumbai - 400 069.
130. Shri Ganesh Pharma,

153/55/57, Samuel Street, 202,
Hingkee BLdg., Mumbai-400 009.
131. Themis Chemicals Ltd.,

11/12, Udyog Nagar, Industrial Estate, S.
V. Road, Goregaon (W), Mumbai - 400
104.
132. Themis Laboratories,

Unit No. S-4, Khira Industrial Estate,
M. Bhargava Road, Santacruz (W),
Mumbai-54
133. Tata Pharma,

Plot no. A/42, MIDC,
Patalganga, Dist. Raigad - 410 207.
134. Transchem Ltd.,

Plot No: 7, MIDC Engineering Zone, Kalyan
Badlapur Road, Ambernath - 421 501.
135. Theenis Agencies,

26, Mahal Industrial Estate, Mahakali
Caves Road, Andheri (E), Mumbai - 093.
136. Theenis Pharmaceuticals,

38, Suren Road,
Andheri (E), Mumbai - 400 093.
110
Contd.......
137. USV Limited,

B-1/8, MIDC, Lote-Parshuram Ind. Area,
Tal. Khed, Dist. Ramagiri, Pin- 415 722.
138. U.C.B. Pharma Ltd.,

A-20, Neelam Centre, Hind Cycle Road,
Worli, Mumbai 400 025.
139.
140. Unique Chemicals,

Plot No: P-10, Shiv-Mahape, P.O. Gansoli,
Dist. Thane, Thane Belapur Road,
Navi Mumbai.
141.
U. C. B. India Ltd.,
VIP House, 1 St Floor, 88-C,
Prabhadevi Road, Mumbai
400 025.
Unichem Laboratories,
Plot No: 99, MIDC Area, Dhatav
Dist. Raigad 402 116.
Roha,
143.
147.
142. Umedica Laboratories Pvt. Ltd.,

Dalamal House, 4 th Floor, Jamnalal Bajaj
Road, Nariman Point, Mumbai 400 021.
-
Unimark Remedies Ltd.,

19, Crystal, 1s t Floor, Juhu Road,
Santakruz (W), Mumbai 400 054.
144. Unilab Chemicals t Pharmaceuticals,

212, Majestic, 144, JSS Road,
Girgaon, Mumbai 400 004.
Unimax Chemicals Pvt. Ltd.,

E-116, MIDC, Tarapur, Tal. Palghar,
Dist. Thane.
146. Ultrachem
Steelmade Ind. Estate, Marol Maroshi
Road, Andheri (E), Mumbai 400 059
Unichem Laboratories Ltd.,

Plot No. 99, MIDC Area,
Dhatav Roha, Dist. Raigad,
Maharashtra -402116.
148. Valiant Industries Ltd.,

74, Matru Smruti, 2 d Floor,
Road -4, Scheme 6, Sion (E),
Mumbai -400002
145.
"
149. V. Tribhovandas Pvt. Ltd.,

Ranvir Mansion, 66/70, Shamaldas Gandhi
Marg, Mumbai 400 002.
150. Vapi Organics Chemicals Pvt. Ltd.,

"Indrayani" Sophia College Road, 61-D,
Bhulabhai Desai Road, Mumbai 400 026.
151. Vista Organics Pvt. Ltd.,

54/A, M. Vasanji Road,
Andheri (E), Mumbai 400 093.
152. Vilco Labs Pvt. Ltd.,

Firdaus, Chimbai Road, Old Kantwadi,
Bandra (W), Mumbai 400 050.
153. Vinubhai Agencies,

145, Sherif Devji Street, Inside Padamsee
Annexe, Mumbai 400 003.
154. Wyeth Laboratories Ltd.,

Nyloc House, 254-D2, Dr. Annine Besant
Road, Mumbai-400 025.
155. Win Chemicals Ltd.,

263, Kaliandas Udyog Bhawan,
Near Century Bhawan, Worli,
Mumbai 400 029.
156. Wockhardt Ltd.,

Wockhardt Towers, Bandra-Kurla
Complex,
Bandra (East), Mumbai-400 051.
157. Western Drugs Pvt. Ltd.,

111/19, Thakurdwar Road,
Mumbai 400 002.
158. Win Labs Ltd.,

A.142-AB Kandivli Industrial Estate,
Kandivli (W), Mumbai 400 067.
159. Yash Pharmachem (Bombay) P. Ltd.

Ganesh Industrial Estate, B/H, Burma
Shell Petrol Pump, Vilt. Valive, Vasai (E),
Thane.
160. Zandu Chemicals Ltd.,

70, Gokhate Road,
South, Dadar, Mumbai 400 025.
161. Zandu Pharma Works Ltd.,

70, Gokhale Road, South,
Mumbai 400 025.
-
111
Contd.......
MADHYA PRADESH
1.
Earnest Healthcare Ltd.,

Earnest Estate, Mumbai-Agra Road,
P. 0. Rajender Nagar,
Indore, Madhya Pradesh - 452 012.
2.
Hi-Tech Drugs Ltd.,

5, Yamnotri, Shastri Nagar,
Ratlam (M.P) - 457 001
3.
Lupin Labs. Ltd.,

198-202, New Industrial Area No. III,
Mandideep-462 046, Dist. Raisen,(MP)
4.
Medilux Laboratories Pvt. Ltd.,

201, B. C. Chambers, 2 nd Floor, 47, Jaora
Compound,Indore-452001, (MP)
5.
Panchsheel Organic Ltd.,

B6-B7, Sector C, Sanver Road, Industrial
Estate, Indore - 452 001.
6.
Sanghi Organics t Phytochem Ltd.,

144, Piplia Rao, Agra-Bombay Road,
Indore-452 001.
ORISSA
1. Basichem India Ltd.,
Harrirajpur, Jatai,
Puri, Orissa.
PUNJAB
1.
Amritsar Pharmaceuticals ft
Laboratories,
Naraingarh, Chheharatta - 143 106,
Amritsar (Punjab).
2.
Altus Organics Ltd.,

B4/B5, Focal Point Ind. Area,
Dera Bassi - 140 507
Patiala Dist., Punjab
3.
Aman Jyothi Drugs Et Pharmaceuticals

Pvt. Ltd.,
115, Industrial Complex, Goindwal Sahib,
Dist. Amristsar, Pun jab - 143 423
4.
Kalsi Pharmaceuticals,
B - 44, Industrial Area, Sas Nagar,
Mohali, Punjab
RAJASTHAN
1. Shashi Phytochemical Industries,
1, Old Indl. Area,
Alwar - 301 001
TAMILNADU
1.
Bansal Metallic Oxides,

L - 136, Anna Nagar,
Chennai - 600 102
3.
Meridian Pharmaceuticals Pvt. Ltd.

No. 13, Old Trunk Road,
Pallavarm, Chennai - 600 043
Orchid Chemicals Et Pharmaceuticals
Ltd.,
1, 6` h Floor, "Crown Court",
34, Cathedral Road, Chennai- 600 086.
5.
7.
Rajyalakshmi Chemicals Ltd.,

1984, 5 th Main Road Anna Nagar (W),
Chennai 600 040
2.
6.
8.
112
ICI India Ltd.

Pharmaceutical division Khaleel Centre
149, Monitieth Road, Chennai - 600 008
4. Malladi Drugs & Pharmaceutical Ltd.,
B - 211, 1 5t Floor, 11 th Avenue,
Ashok Nagar, Chennai - 600 083
Orient Pharma Pvt. Ltd.,
Old Trunk Road,
Pallawaram, Chennai - 600 043.
Shasun Chemical (Madras) Pvt. Ltd.,

No. 2, Doraiswamy Road,
T. Nagar, Chennai - 600 017.
Contd.......
9.
Shasun Chemicals & Drugs Ltd.,

13, Nageswara Rao Road,
Chennai - 600 017.
10. SPIC Pharmaceuticals Ltd.,
SPIC Center, Annexe, 6 th Floor, 97,

Mount Road, Chennai-600 032.
11. Sviss Labs Limited,

88/89, Phase II, SIPCOT, Ranipet, Dist.
North Arcot, Tamil Nadu-632 403.
12. TTK Pharma Ltd.,

Old Trunk Road, Pallavaram,
Chennai - 600 043.
UTTAR PRADESH
1.
D. P. Chem Ltd.
329/2, Jhokam Bagh, Jhansi, U.P.
2.
3. Meditech Chemicals Pvt. Ltd.,

105, Site IV, Indl. Area,
Sahibabad - 201 010, Ghaziabad
5.
4.
Indian Herbs Research t Supply Co. (P) Ltd.

Sharda Nagar, Saharanpur - 247 001 U.P
Rajshi Chemical Products
81-Roop Nagar Indl. Area,

Loni-Ghazibad, Uttar Pradesh
Synthochem,
7-B, Shahajahapur Road,
Bareill -243 005 U.P
WEST BENGAL
2. Amalgamated Drugs Et Pharmaceuticals Ltd.
15,'kusum', 11, Gurusaday Road,
Calcutta-700 019.
1. Albert Davis Ltd.,

15, Chittaranjan Avenue,
Calcutta-700 072.
3.
Bengal Chemicals t Pharmaceutical
4.
Bengal Immunity Ltd.,

Immunity House,
153, Lenin Saranee, Calcutta 700 013.
6.
Reckitt & Coleman of India Ltd.,

41, Chowringhee Road,
Kolkatta - 700 071.
Ltd.
6, Ganesh Chunder Avenue,
Calcutta - 700 013.
5.
East India Pharmaceutical Works Ltd.,
6, Little-Russel Street,
Calcutta - 71, W.B.
TRADE ASSOCIATIONS
1. Pharmaceutical and Allied
Manufacturers Association (PAMDAL)
C/o Bombay Chambers of Commerce and
Industry, Mackinnon Mackenzie Building,
Ballard Estate, Mumbai - 400 001
2. Organization of Pharmaceutical Producers
3.
4.
Indian Drugs Manufacturing Association
of India (OPPI)
Penmella Chamber,
G.P. Ganpat Rao Kadamb Marg,
Lower Parel, Mumbai - 400 013
(IDMA)
102-B, Poonam Chambers,
Dr. A.B. Road, Worli,
Mumbai - 400 018
5.
Bulk Drug Manufacturing Association

(BDMA)
C-25, Industrial Estate

Near State Bank of Hyderabad,
Sanath Nagar, Hyderabad - 500 018
Indian Chemical Manufacturers

Association (ICMA)
5` h Floor, Manek Mahal,
90, Veer Nariman Road,
Church Gate, Mumbai - 400 020
113

Guidelines For Optimum Water Consumption in Bulk Drugs Manufacturing Industry PDF

Hochgeladen von

Dokumentinformationen

Originalbeschreibung:

Originaltitel

Copyright

Verfügbare Formate

Dieses Dokument teilen

Dokument teilen oder einbetten

Freigabeoptionen

Stufen Sie dieses Dokument als nützlich ein?

Sind diese Inhalte unangemessen?

Copyright:

Verfügbare Formate

Guidelines For Optimum Water Consumption in Bulk Drugs Manufacturing Industry PDF

Hochgeladen von

Copyright:

Verfügbare Formate

Froqrai'nme Objective Series

Fiobes 117 2007

e-mail: cpcb@.nic.in Website : www.cpcb.nic.in

PROGRAMME OBJECTIVE SERIES

CPCB, 200 Copies, 2007

Central Pollution Control Board

;:j.. 9T, ^t.u..

sustainable development in all spheres of human life. The Government of

Engineers Pvt. Ltd., Vadodara is gratefully acknowledged.

Dr. B. Sengupta, Member Secretary

Sh. N.K. Verma, Ex Additional Director -

Sh. P.M. Ansari, Additional Director

Dr. R.S. Mahwar, Additional Director

Dr. D.D. Basu, Senior Scientist

Guidance and supervision

Sh. Paritosh Kumar, Sr. Env. Engineer -

Sh. Dinabandhu Gouda, Env. Engineer -

Data compilation, analysis and

Sh. N.S. Babu, Ex Env. Engineer

Sh. K. P. Rathi, DEO Gr -II

Sh. Atul Sharma, JLA

M/s. Associated Environmental

2.0 Status of Bulk Drug Sector

Pharmaceutical Sector in India

Findings of Industry Survey on Bulk Drug Manufacturers

Current trends in Indian Pharmaceutical Sector

3.0 Results and Discussions

3.1.1 Level-I Questionnaire Survey

Water consumption pattern

3.2.1 General trends of water consumption and potential

Variation of water consumption due to

4.0 Guideline for Water Consumption for Selected Bulk Drugs

Unit for water Consumption

4.4.1 Selection of Bulk Drugs

Level-I Responses of Company-wise

Response of Level-II Questionnaire Survey

Water Balance Sheet

Level-I Calculation of Utility Water Company-wise on

Name and Address of Bulk Drug Industries in India (State-wise)

Classification of Bulk Drugs

Production of Bulk Drugs

Production of Bulk drugs in terms of Therapeutic class during

Imports of drugs and pharmaceuticals

Exports of drugs and pharmaceuticals

Typical contract manufacturing deals in India

Fifty three therapeutically classes covering 186 drugs

Selected Industries and Drugs for final visit

Calculation of Process and Utility Water

Distribution of Bulk Drug Industries India

Sector Wise distribution of Pharmaceutical Industry in India

Line Chart for production volume

Line Chart for number of Manufacturers

Water Consumption and Wastewater generation pattern in

Streams arise from Bulk Drug (Organic Synthetic) Industry

Stream wise BPT in Bulk Drug Industries

A typical fermentation process flow diagram for

Active Pharmaceutical Ingredients

Environmental Management System

Effluent Treatment Plant

Federation of Indian Chamber of Commerce &t Industry

Indian Chemical Manufacturers Association

Indian Drug Manufacturing Association