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Guidelines for the use of the Cockcroft & Gault Formula to calculate
Creatinine Clearance in Adult Cancer Patients
The Cockcroft and Gault (C & G) formula is used to assess a patients renal function, in the absence of an
EDTA, as per guidelines in individual chemotherapy protocols.
Please note that eGFR should not be used to adjust doses for any medicines, including chemotherapy.
C & G Formula for MALE:
Creatinine Clearance = 1.23 x (140 - age in years) x TBW* (in kg) or Adjusted Body Weight (see below)
Serum Creatinine (mol/L)
C & G Formula for FEMALE:
Creatinine Clearance = 1.04 x (140 - age in years) x TBW* (in kg) or Adjusted Body Weight (see below)
Serum Creatinine (mol/L)
*TBW = Total body weight
The C & G formula needs to be interpreted with caution in patients who are:
Obese
o If the patients Total Body Weight (TBW) is more than 130% of their Lean Body Weight
(LBW), as calculated below, using the patients TBW in the C&G calculation will
overestimate renal function.
o Instead, use the Adjusted body weight, which falls between lean body weight and total
body weight as follows:
Adjusted body weight = LBW + 0.4 (TBW LBW)
To calculate Lean Body Weight (LBW) for MALE:
LBW (kg) = 50 + (0.906 x (height in cm 152.4))
To calculate Lean Body Weight (LBW) for FEMALE:
LBW (kg) = 45 + (0.906 x (height in cm 152.4))
Emaciated
o Use TBW in the C & G calculation
Churchills Clinical Pharmacy Survival Guide. Barber & Wilson, Churchill Livingstone
1999
Basic Clinical Pharmacokinetics Michael Winter 3rd Edition, Applied Therapeutics Inc.
Vancouver, 1994.
Devine, BJ. Drug Intell Clin Pharm 1974 (7): 650 655
Devaney, A et al; Pharm J 2006; 277: 403 404