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and Head, Department of Oral Medicine and Radiology, Daswani Dental College, Kota, Rajasthan, India.
2Reader, Department of Oral Medicine and Radiology, Daswani Dental College, Kota, Rajasthan, India.
3Senior Lecturer, Department of Periodontics, Daswani Dental College, Kota, Rajasthan, India.
4Senior Lecturer, Department of Periodontics, Daswani Dental College, Kota, Rajasthan, India.
5Senior Lecturer, Department of Oral Pathology, Daswani Dental College, Kota, Rajasthan, India.
ABSTRACT
Background: Trigeminal neuralgia is a relatively common neuropathic pain which is characterized by
paroxysmal, sharp, shooting, shocking or piercing pain in relation to branches of fifth cranial nerve. The pain is
usually uni-lateral lasting only for few seconds but sometimes may extend to few minutes. Various treatments
extending from medical to neurosurgical procedures are available. Carbamazepin being the first prefered drug
for the treatment of trigeminal neuralgia. The latest drug to hit the market is an antiepileptic drug pregabalin
(Lyrica) . This article reviews the efficacy and use of pregabalin in treatment of trigeminal neuralgia
Keywords: Trigeminal neuralgia, Pregabalin,neuropathic pain.
INTRODUCTION
Trigeminal neuralgia (TGN) is a debilitating
neuropathic pain of maxillofacial region. The
disease is characterized by sharp, shooting, boring,
lancinating and piercing pain in relation to branches
of fifth cranial nerve.1,2 The pain attacks may result
from physiologic changes induced by chronic partial
injury to the brain stem trigeminal nerve root from
a variety of causes.3 The pain is characteristically
paroxysmal and is usually unilateral. The affected
nerves are responsible for sensing touch,
temperature sensation and pressure sensation in
the facial area from the jaw to the forehead 4
So pain is usually provoked by a mechanical
tactile stimulus like eating, talking, washing the face,
cleaning the teeth or touching to any area of face or
mouth. Sometimes, the pain may occur
spontaneously. However, there is no associated
neurosensory or motor nerve deficit.1
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CONCLUSION
It is essential that clinicians recognize and
diagnose trigeminal neuralgia correctly for patients
to receive appropriate referral and therapy for this
relatively treatable condition. Meanwhile, patients
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Lyrica.http://www.emea.eu.int/humandocs/Hu
mans/EPAR/lyrica/lyrica.htm.
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