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Harrison'sOnlineFeatures

FeaturingthecompletecontentsofHarrison'sPrinciplesof
InternalMedicine,17thEdition

GrandRounds ViewAll

AnthonyS.Fauci,EugeneBraunwald,DennisL.Kasper,StephenL.Hauser,DanL.
Longo,J.LarryJameson,andJosephLoscalzo,Eds.

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HerpesSimplexViruses:
NeurologicalComplications
byDenaB.Dubal,MD,PhD

PrefaceCopyrightContributors

CONTENTS

EarnCMECredit

Part1.IntroductiontoClinicalMedicine

UpdatesViewAll

Chapter1 ThePracticeofMedicine

Chapter2 GlobalIssuesinMedicine

Chapter3 DecisionMakinginClinicalMedicine

Chapter4 ScreeningandPreventionofDisease

Chapter5 PrinciplesofClinicalPharmacology

Chapter6 Women'sHealth

Chapter7 MedicalDisordersduringPregnancy

Chapter8 MedicalEvaluationoftheSurgicalPatient

Chapter9 GeriatricMedicine

Chapter10 ComplementaryandAlternativeMedicine

LatestUpdate:
12/15/08:GinkgoBilobaTreatmentIneffectiveinPreventing
Dementia

Chapter11 PalliativeandEndofLifeCare

LatestUpdate:
07/15/08:Methylnaltrexone:ReliefforOpiateInduced
Constipation
Chaptere1 TheSafetyandQualityofHealthCare
Chaptere2 EconomicConsiderationsinthePracticeofMedicine
Chaptere3 RacialandEthnicDisparitiesinHealthCare
Chaptere4 EthicalIssuesinClinicalMedicine

Part2.CardinalManifestationsandPresentationofDiseases
Section1.Pain

Chapter12 Pain:PathophysiologyandManagement

Chapter13 ChestDiscomfort

Chapter14 AbdominalPain

Chapter15 Headache

LatestUpdate:
08/12/08:RighttoLeftCardiacShuntsNotRelatedtoBrain
LesionsinMigrainewithAuraPatients

Chapter16 BackandNeckPain

LatestUpdate:
03/10/08:SurgicalTreatmentofLumbarSpinalStenosis
MayBeEffective

12/15/2008:GinkgoBilobaTreatment
IneffectiveinPreventingDementia
12/10/2008:DepressioninCoronary
HeartDiseaseMaybeExplainedby
PhysicalInactivity
12/9/2008:HotTopic:Chronic
HepatitisC:AReassessmentofLong
TermTreatment

EmergencyMedicine
PhotoGallery
SelectedcasesfromtheAtlas
ofEmergencyMedicine.
ViewGallery

SelfAssessment
Over1,000questions.TakeaTest

AccessMedicine|Harrison'sPrinciplesofInternalMedicine,17e

Section2.AlterationsinBodyTemperature

Chapter17 FeverandHyperthermia

Chapter18 FeverandRash
Chaptere5 AtlasofRashesAssociatedwithFever

Chapter19 FeverofUnknownOrigin

Chapter20 HypothermiaandFrostbite

Section3.NervousSystemDysfunction

Chapter21 Syncope

LatestUpdate:
04/15/08:NeurallyMediatedSyncopeMayBeDrivenBy
ExaggeratedResponsetoHypocapnia

Chapter22 DizzinessandVertigo

LatestUpdate:
07/17/08:AnEvidenceBasedReviewofTreatmentsfor
BenignParoxysmalPositionalVertigo(BPPV)

Chapter23 WeaknessandParalysis

Chapter24 GaitandBalanceDisorders

Chapter25 Numbness,Tingling,andSensoryLoss

Chapter26 ConfusionandDelirium
Chaptere6 MemoryLoss

Chapter27 Aphasia,MemoryLoss,andOtherFocalCerebral

Chapter28 SleepDisorders

Disorders

Section4.DisordersofEyes,Ears,Nose,andThroat

Chapter29 DisordersoftheEye

Chapter30 DisordersofSmell,Taste,andHearing

Chapter31 Pharyngitis,Sinusitis,Otitis,andOtherUpper

RespiratoryTractInfections
LatestUpdate:
03/03/08:ImpactofTreatmentwithAzithromycinor
ClarithromycinonEmergenceofMacrolideResistanceinthe
OralStreptococcalFloraofHealthyVolunteers

Chapter32 OralManifestationsofDisease
Chaptere7 AtlasofOralManifestationsofDisease

Section5.AlterationsinCirculatoryandRespiratoryFunctions

Chapter33 DyspneaandPulmonaryEdema

Chapter34 CoughandHemoptysis

Chapter35 HypoxiaandCyanosis

Chapter36 Edema
Chaptere8 ApproachtothePatientwithaHeartMurmur

Chapter37 Palpitations

Section6.AlterationsinGastrointestinalFunction

Chapter38 Dysphagia

Chapter39 Nausea,Vomiting,andIndigestion

Chapter40 DiarrheaandConstipation

LatestUpdate:
06/26/08:OpioidInducedConstipation:ANewTherapeutic
Approach

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AccessMedicine|Harrison'sPrinciplesofInternalMedicine,17e

Chapter41 WeightLoss

Chapter42 GastrointestinalBleeding

Chapter43 Jaundice

Chapter44 AbdominalSwellingandAscites

Section7.AlterationsinRenalandUrinaryTractFunction

Chapter45 AzotemiaandUrinaryAbnormalities
Chaptere9 AtlasofUrinarySedimentsandRenalBiopsies

Chapter46 FluidandElectrolyteDisturbances

Chapter47 HypercalcemiaandHypocalcemia

Chapter48 AcidosisandAlkalosis

Section8.AlterationsinSexualFunctionandReproduction

Chapter49 SexualDysfunction

Chapter50 HirsutismandVirilization

Chapter51 MenstrualDisordersandPelvicPain

Section9.AlterationsintheSkin

Chapter52 ApproachtothePatientwithaSkinDisorder

Chapter53 Eczema,Psoriasis,CutaneousInfections,Acne,and

OtherCommonSkinDisorders

Chapter54 SkinManifestationsofInternalDisease

Chapter55 ImmunologicallyMediatedSkinDiseases

Chapter56 CutaneousDrugReactions

Chapter57 PhotosensitivityandOtherReactionstoLight
Chaptere10 AtlasofSkinManifestationsofInternalDisease

Section10.HematologicAlterations

Chapter58 AnemiaandPolycythemia

Chapter59 BleedingandThrombosis

Chapter60 EnlargementofLymphNodesandSpleen

Chapter61 DisordersofGranulocytesandMonocytes
Chaptere11 AtlasofHematologyandAnalysisofPeripheralBlood

Smears
Part3.GeneticsandDisease

Chapter62 PrinciplesofHumanGenetics

Chapter63 ChromosomeDisorders

Chapter64 ThePracticeofGeneticsinClinicalMedicine

Chapter65 GeneTherapyinClinicalMedicine

LatestUpdate:
05/14/08:GeneTherapyforaDegenerativeRetinalDisease
Part4.RegenerativeMedicine

Chapter66 StemCellBiology

Chapter67 ApplicationsofStemCellBiologyinClinicalMedicine

Chapter68 HematopoieticStemCells

Chapter69 TissueEngineering

Part5.Nutrition

Chapter70 NutritionalRequirementsandDietaryAssessment

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AccessMedicine|Harrison'sPrinciplesofInternalMedicine,17e

Chapter71 VitaminandTraceMineralDeficiencyandExcess

Chapter72 MalnutritionandNutritionalAssessment

Chapter73 EnteralandParenteralNutritionTherapy

Chapter74 BiologyofObesity

Chapter75 EvaluationandManagementofObesity

LatestUpdate:
03/25/08:APossibleNewMechanismtoControlObesity

Chapter76 EatingDisorders

Part6.OncologyandHematology
Section1.NeoplasticDisorders

Chapter77 ApproachtothePatientwithCancer

LatestUpdate:
07/02/08:DistinctPatternsofCancerIncidenceinPatients
InfectedwithHIV

Chapter78 PreventionandEarlyDetectionofCancer

Chapter79 CancerGenetics

Chapter80 CancerCellBiologyandAngiogenesis

LatestUpdate:
11/02/07:AnEpothiloneApprovedforUseinMetastatic
BreastCancer

Chapter81 PrinciplesofCancerTreatment

Chapter82 InfectionsinPatientswithCancer

Chapter83 CanceroftheSkin

Chapter84 HeadandNeckCancer

LatestUpdate:
10/31/07:AdditionofDocetaxeltoCisplatinand5
FluorouracilImprovesOutcomesinHeadandNeckCancer

Chapter85 NeoplasmsoftheLung

Chapter86 BreastCancer

LatestUpdate:
01/29/08:PaclitaxelContainingAdjuvantChemotherapyIs
ParticularlyEffectiveinHER2PositiveBreastCancer

Chapter87 GastrointestinalTractCancer

LatestUpdate:
10/07/08:ProgressonColonCancerScreening

Chapter88 TumorsoftheLiverandBiliaryTree

LatestUpdate:
11/11/08:HotTopic:HepatocellularCarcinoma:Abilityto
PredictOutcomeUsingGeneExpressionAnalysisonFixed
Tissues

Chapter89 PancreaticCancer

Chapter90 BladderandRenalCellCarcinomas

Chapter91 BenignandMalignantDiseasesoftheProstate

LatestUpdate:
04/02/08:SerumTestosteroneLevelsDoNotAffect
ProstateCancerRisk

Chapter92 TesticularCancer

LatestUpdate:
09/04/07:CurabilityofRelapsedMetastaticTesticular
Cancer

Chapter93 GynecologicMalignancies

Chapter94 SoftTissueandBoneSarcomasandBoneMetastases

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Chapter95 CarcinomaofUnknownPrimary

Chapter96 ParaneoplasticSyndromes:

Endocrinologic/Hematologic

Chapter97 ParaneoplasticNeurologicSyndromes
Chaptere12 Thymoma
Chaptere13 LateConsequencesofCancerandItsTreatment

Section2.HematopoieticDisorders

Chapter98 IronDeficiencyandOtherHypoproliferativeAnemias

Chapter99 DisordersofHemoglobin

LatestUpdate:
06/30/08:HydroxyureaImprovestheClinicalCoursein
AdultswithSickleCellAnemia
Chapter100 MegaloblasticAnemias
Chapter101 HemolyticAnemiasandAnemiaDuetoAcuteBlood

Loss
Chapter102 AplasticAnemia,Myelodysplasia,andRelatedBone

MarrowFailureSyndromes
Chapter103 PolycythemiaVeraandOtherMyeloproliferative

Diseases
Chapter104 AcuteandChronicMyeloidLeukemia
Chapter105 MalignanciesofLymphoidCells
Chapter106 PlasmaCellDisorders
Chapter107 TransfusionBiologyandTherapy

LatestUpdate:
07/03/08:YoungBlood:DoesItMatter?
Chapter108 HematopoieticCellTransplantation

Section3.DisordersofHemostasis
Chapter109 DisordersofPlateletsandVesselWall
Chapter110 CoagulationDisorders
Chapter111 VenousThrombosis
Chapter112 Antiplatelet,Anticoagulant,andFibrinolyticDrugs

LatestUpdate:
07/07/08:FatalAllergicReactionstoHeparin:Problem
Solved
Part7.InfectiousDiseases
Section1.BasicConsiderationsinInfectiousDiseases
Chapter113 IntroductiontoInfectiousDiseases:HostPathogen

Interactions
Chapter114 MolecularMechanismsofMicrobialPathogenesis
Chapter115 ApproachtotheAcutelyIllInfectedFebrilePatient
Chapter116 ImmunizationPrinciplesandVaccineUse

LatestUpdate:
07/15/08:Phase1andPhase2ClinicalTrialsofaWhole
VirusH5N1InfluenzaVaccineDerivedfromCellCulture
Chapter117 HealthAdviceforInternationalTravel

LatestUpdate:
07/18/08:EfficacyandSafetyofaVaccinePatchAgainst
Travelers'DiarrheaCausedbyEnterotoxigenicEscherichia
coli
Chaptere14 LaboratoryDiagnosisofInfectiousDiseases

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Section2.ClinicalSyndromes:CommunityAcquiredInfections
Chapter118 InfectiveEndocarditis

LatestUpdate:
01/14/08:ProstheticValveEndocarditis:CurrentClinical
ProfileandOutcome
Chapter119 InfectionsoftheSkin,Muscle,andSoftTissues
Chapter120 Osteomyelitis
Chapter121 IntraabdominalInfectionsandAbscesses

LatestUpdate:
01/22/08:RelaparotomyinSeverePeritonitis:Comparison
ofanOnDemandvsaPlannedStrategy
Chapter122 AcuteInfectiousDiarrhealDiseasesandBacterialFood

Poisoning
Chapter123 ClostridiumdifficileAssociatedDisease,Including

PseudomembranousColitis
LatestUpdate:
09/25/07:HotTopic:ClostridiumdifficileColitis:IsItNow
MoreCommonandMoreSevereinHospitalizedPatients?
Chapter124 SexuallyTransmittedInfections:OverviewandClinical

Approach
Chaptere15 InfectiousComplicationsofBurnsandBites

Section3.ClinicalSyndromes:HealthCareAssociatedInfections
Chapter125 HealthCareAssociatedInfections

LatestUpdate:
09/29/08:CommonContaminationofGlovesandGowns
withMethicillinResistantStaphylococcusaureusand
VancomycinResistantEnterococciduringRoutinePatient
Care
Chapter126 InfectionsinTransplantRecipients

Section4.ApproachtoTherapyforBacterialDiseases
Chapter127 TreatmentandProphylaxisofBacterialInfections

Section5.DiseasesCausedbyGramPositiveBacteria
Chapter128 PneumococcalInfections

LatestUpdate:
06/30/08:LackofImpactofAdjuvantGlucocorticoidson
TimetoDeathorHospitalDischargeinChildrenwith
BacterialMeningitis
Chapter129 StaphylococcalInfections

LatestUpdate:
04/25/08:HotTopic:EpidemiologyofInvasiveInfections
DuetoMethicillinResistantStaphylococcusaureusinthe
UnitedStates
Chapter130 StreptococcalandEnterococcalInfections

LatestUpdate:
06/19/08:RecentTrendsintheEpidemiologyofInvasive
GroupBStreptococcalDisease
Chapter131 DiphtheriaandOtherInfectionsCausedby

CorynebacteriaandRelatedSpecies
Chapter132 InfectionsCausedbyListeriamonocytogenes
Chapter133 Tetanus
Chapter134 Botulism
Chapter135 GasGangreneandOtherClostridialInfections

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AccessMedicine|Harrison'sPrinciplesofInternalMedicine,17e

Section6.DiseasesCausedbyGramNegativeBacteria
Chapter136 MeningococcalInfections
Chapter137 GonococcalInfections
Chapter138 MoraxellaInfections
Chapter139 HaemophilusInfections
Chapter140 InfectionsDuetotheHACEKGroupandMiscellaneous

GramNegativeBacteria
Chapter141 LegionellaInfection
Chapter142 PertussisandOtherBordetellaInfections
Chapter143 DiseasesCausedbyGramNegativeEntericBacilli
Chapter144 HelicobacterpyloriInfections

LatestUpdate:
12/28/07:GastricMucosaAssociatedLymphoidTissue
(MALT)Lymphoma:BenefitsofaWatchandWaitStrategy
Chapter145 InfectionsDuetoPseudomonasSpeciesandRelated

Organisms
Chapter146 Salmonellosis
Chapter147 Shigellosis
Chapter148 InfectionsDuetoCampylobacterandRelatedSpecies
Chapter149 CholeraandOtherVibrioses
Chapter150 Brucellosis
Chapter151 Tularemia
Chapter152 PlagueandOtherYersiniaInfections
Chapter153 BartonellaInfections,IncludingCatScratchDisease
Chapter154 Donovanosis

Section7.MiscellaneousBacterialInfections
Chapter155 Nocardiosis
Chapter156 Actinomycosis
Chapter157 InfectionsDuetoMixedAnaerobicOrganisms

Section8.MycobacterialDiseases
Chapter158 Tuberculosis

LatestUpdate:
10/03/08:HotTopic:EpidemiologyofTuberculosisamong
ForeignBornResidentsoftheUnitedStates
Chapter159 Leprosy(Hansen'sDisease)
Chapter160 NontuberculousMycobacteria
Chapter161 AntimycobacterialAgents

Section9.SpirochetalDiseases
Chapter162 Syphilis
Chapter163 EndemicTreponematoses
Chapter164 Leptospirosis
Chapter165 RelapsingFever
Chapter166 LymeBorreliosis

Section10.DiseasesCausedbyRickettsiae,Mycoplasmas,andChlamydiae
Chapter167 RickettsialDiseases
Chapter168 InfectionsDuetoMycoplasmas

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AccessMedicine|Harrison'sPrinciplesofInternalMedicine,17e

Chapter169 ChlamydialInfections

Section11.ViralDiseases:GeneralConsiderations
Chapter170 MedicalVirology
Chapter171 AntiviralChemotherapy,ExcludingAntiretroviralDrugs

Section12.InfectionsDuetoDNAViruses
Chapter172 HerpesSimplexViruses
Chapter173 VaricellaZosterVirusInfections

LatestUpdate:
01/10/08:VaccineInducedImmunitytoVaricella:Decrease
overTimeandValueofaSecondVaccineDose
Chapter174 EpsteinBarrVirusInfections,IncludingInfectious

Mononucleosis
Chapter175 CytomegalovirusandHumanHerpesvirusTypes6,7,

and8
Chapter176 MolluscumContagiosum,Monkeypox,andOther

Poxviruses,ExcludingSmallpoxVirus
Chapter177 ParvovirusInfections
Chapter178 HumanPapillomavirusInfections

LatestUpdate:
02/28/08:GenitalInfectionwithHumanPapillomavirus:
HighIncidenceinaCohortofYoungMen
Section13.InfectionsDuetoDNAandRNARespiratoryViruses
Chapter179 CommonViralRespiratoryInfectionsandSevereAcute

RespiratorySyndrome(SARS)
Chapter180 Influenza

LatestUpdate:
02/25/08:InfluenzaVaccinationoftheCommunityDwelling
ElderlyPopulation:LongTermExaminationofEfficacy
Section14.InfectionsDuetoHumanImmunodeficiencyVirusandOther
HumanRetroviruses
Chapter181 TheHumanRetroviruses
Chapter182 HumanImmunodeficiencyVirusDisease:AIDSand

RelatedDisorders
LatestUpdate:
08/14/08:HotTopic:SixtyPercentofU.S.AdultsHave
NeverBeenTestedforHIVInfection
Section15.InfectionsDuetoRNAViruses
Chapter183 ViralGastroenteritis
Chapter184 EnterovirusesandReoviruses
Chapter185 Measles(Rubeola)
Chapter186 Rubella(GermanMeasles)
Chapter187 Mumps

LatestUpdate:
07/23/08:TheResurgenceofMumps:PossibleNeedfor
VaccinePolicyChanges
Chapter188 RabiesandOtherRhabdovirusInfections
Chapter189 InfectionsCausedbyArthropodandRodentBorne

Viruses
Chapter190 EbolaandMarburgViruses

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AccessMedicine|Harrison'sPrinciplesofInternalMedicine,17e

Section16.FungalandAlgalInfections
Chapter191 DiagnosisandTreatmentofFungalInfections

LatestUpdate:
10/16/08:LackofEfficacyofEmpiricalFluconazolein
IntensiveCareUnitPatientsatHighRiskofInvasive
Candidiasis
Chapter192 Histoplasmosis
Chapter193 Coccidioidomycosis
Chapter194 Blastomycosis
Chapter195 Cryptococcosis
Chapter196 Candidiasis

LatestUpdate:
01/23/08:Anidulafungin:EqualorSuperiortoFluconazole
fortheTreatmentofInvasiveCandidiasis
Chapter197 Aspergillosis
Chapter198 Mucormycosis
Chapter199 MiscellaneousMycosesandAlgalInfections
Chapter200 PneumocystisInfection

Section17.ProtozoalandHelminthicInfections:GeneralConsiderations
Chaptere16 LaboratoryDiagnosisofParasiticInfections
Chapter201 AgentsUsedtoTreatParasiticInfections
Chaptere17 PharmacologyofAgentsUsedtoTreatParasitic

Infections
Section18.ProtozoalInfections
Chapter202 AmebiasisandInfectionwithFreeLivingAmebas
Chapter203 Malaria
Chapter204 Babesiosis
Chaptere18 AtlasofBloodSmearsofMalariaandBabesiosis
Chapter205 Leishmaniasis

LatestUpdate:
02/04/08:Paromomycin:AValuableDrugintheTreatment
ofKalaAzar
Chapter206 Trypanosomiasis
Chapter207 ToxoplasmaInfections
Chapter208 ProtozoalIntestinalInfectionsandTrichomoniasis

Section19.HelminthicInfections
Chapter209 TrichinellaandOtherTissueNematodes
Chapter210 IntestinalNematodes
Chapter211 FilarialandRelatedInfections
Chapter212 SchistosomiasisandOtherTrematodeInfections
Chapter213 Cestodes

Part8.BioterrorismandClinicalMedicine
Chapter214 MicrobialBioterrorism
Chapter215 ChemicalBioterrorism
Chapter216 RadiationBioterrorism

Part9.DisordersoftheCardiovascularSystem
Section1.IntroductiontoCardiovascularDisorders

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AccessMedicine|Harrison'sPrinciplesofInternalMedicine,17e

Chapter217 BasicBiologyoftheCardiovascularSystem
Chapter218 EpidemiologyofCardiovascularDisease
Chapter219 ApproachtothePatientwithPossibleCardiovascular

Disease
Section2.DiagnosisofCardiovascularDisorders
Chapter220 PhysicalExaminationoftheCardiovascularSystem
Chapter221 Electrocardiography
Chaptere19 AtlasofElectrocardiography
Chapter222 NoninvasiveCardiacImaging:Echocardiography,

NuclearCardiology,andMRI/CTImaging
Chaptere20 AtlasofNoninvasiveCardiacImaging
Chapter223 DiagnosticCardiacCatheterizationandAngiography

Section3.DisordersofRhythm
Chapter224 PrinciplesofElectrophysiology
Chapter225 TheBradyarrhythmias

LatestUpdate:
07/14/08:Omega3FattyAcidsandCoronaryHeartDisease
Risk
Chapter226 TheTachyarrhythmias

LatestUpdate:
07/28/08:LongQTSyndrome:Lessonsfromthe
InternationalLQTSRegistry
Chaptere21 AtlasofCardiacArrhythmias

Section4.DisordersoftheHeart
Chapter227 HeartFailureandCorPulmonale

LatestUpdate:
06/09/08:CardiacResynchronizationTherapyinPatients
withaNarrowQRSDuration
Chapter228 CardiacTransplantationandProlongedAssisted

Circulation
Chapter229 CongenitalHeartDiseaseintheAdult
Chapter230 ValvularHeartDisease

LatestUpdate:
01/08/08:AssessmentofValvularHeartDiseasebyCT
Chapter231 CardiomyopathyandMyocarditis

LatestUpdate:
08/08/08:LeftVentricularApicalBallooningSyndrome
Chapter232 PericardialDisease
Chapter233 TumorsandTraumaoftheHeart
Chapter234 CardiacManifestationsofSystemicDisease

Section5.VascularDisease
Chapter235 ThePathogenesis,Prevention,andTreatmentof

Atherosclerosis
Chaptere22 AtlasofAtherosclerosis
Chapter236 TheMetabolicSyndrome
Chapter237 IschemicHeartDisease
Chapter238 UnstableAnginaandNonSTElevationMyocardial

Infarction
Chapter239 STSegmentElevationMyocardialInfarction

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AccessMedicine|Harrison'sPrinciplesofInternalMedicine,17e

LatestUpdate:
06/24/08:StrategiesforReducingtheDoortoBalloonTime
inAcuteMyocardialInfarction
Chapter240 PercutaneousCoronaryIntervention
Chaptere23 AtlasofPercutaneousRevascularization
Chapter241 HypertensiveVascularDisease
Chapter242 DiseasesoftheAorta
Chapter243 VascularDiseasesoftheExtremities

LatestUpdate:
07/21/08:RivaroxabaninthePreventionandTreatmentof
DeepVenousThrombosis
Chapter244 PulmonaryHypertension

Part10.DisordersoftheRespiratorySystem
Section1.DiagnosisofRespiratoryDisorders
Chapter245 ApproachtothePatientwithDiseaseoftheRespiratory

System
Chapter246 DisturbancesofRespiratoryFunction
Chapter247 DiagnosticProceduresinRespiratoryDisease
Chaptere24 AtlasofChestImaging

Section2.DiseasesoftheRespiratorySystem
Chapter248 Asthma
Chapter249 HypersensitivityPneumonitisandPulmonaryInfiltrates

withEosinophilia
Chapter250 EnvironmentalLungDisease
Chapter251 Pneumonia
Chapter252 BronchiectasisandLungAbscess
Chapter253 CysticFibrosis
Chapter254 ChronicObstructivePulmonaryDisease

LatestUpdate:
12/08/08:LackofEffectofChronicAnticholinergicTherapy
ontheProgressionofChronicObstructiveLungDisease
Chapter255 InterstitialLungDiseases
Chaptere40 New!AltitudeIllness:AcuteMountainSickness,High

AltitudePulmonaryEdema,andHighAltitudeCerebral
Edema
Chapter256 DeepVenousThrombosisandPulmonary

Thromboembolism
LatestUpdate:
07/25/08:RivaroxabanforPreventionofVenous
Thromboembolism
Chapter257 DisordersofthePleuraandMediastinum
Chapter258 DisordersofVentilation

LatestUpdate:
06/18/08:DiaphragmaticPacing
Chapter259 SleepApnea
Chapter260 LungTransplantation

LatestUpdate:
03/14/08:BilateralversusSingleLungTransplantation
Part11.CriticalCareMedicine
Section1.RespiratoryCriticalCare

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AccessMedicine|Harrison'sPrinciplesofInternalMedicine,17e

Chapter261 PrinciplesofCriticalCareMedicine
Chapter262 AcuteRespiratoryDistressSyndrome
Chapter263 MechanicalVentilatorySupport

Section2.ShockandCardiacArrest
Chapter264 ApproachtothePatientwithShock
Chapter265 SevereSepsisandSepticShock
Chapter266 CardiogenicShockandPulmonaryEdema

LatestUpdate:
09/14/07:RiskandBenefitofThrombolysisand
PercutaneousCoronaryInterventioninElderlySTElevation
MyocardialInfarctionPatients
Chapter267 CardiovascularCollapse,CardiacArrest,andSudden

CardiacDeath
LatestUpdate:
02/22/08:ConsequencesofDelayedDefibrillationafterIn
HospitalCardiacArrest
Section3.NeurologicCriticalCare
Chapter268 Coma

LatestUpdate:
05/07/08:StudyofPathologyofBrainDeathPatients
RevealsHeterogeneity
Chapter269 NeurologicCriticalCare,IncludingHypoxicIschemic

EncephalopathyandSubarachnoidHemorrhage
LatestUpdate:
01/16/08:UseofDexmedetomidineinICUforSedation
LeadstoLessDeliriumandComaComparedwithLorazepam
Section4.OncologicEmergencies
Chapter270 OncologicEmergencies

Part12.DisordersoftheKidneyandUrinaryTract
Chapter271 CellularandMolecularBiologyoftheKidney
Chapter272 AdaptationoftheKidneytoRenalInjury
Chapter273 AcuteRenalFailure
Chapter274 ChronicKidneyDisease
Chapter275 DialysisintheTreatmentofRenalFailure
Chapter276 TransplantationintheTreatmentofRenalFailure
Chapter277 GlomerularDiseases
Chapter278 PolycysticKidneyDiseaseandOtherInheritedTubular

Disorders
Chapter279 TubulointerstitialDiseasesoftheKidney
Chapter280 VascularInjurytotheKidney
Chapter281 Nephrolithiasis
Chapter282 UrinaryTractInfections,Pyelonephritis,andProstatitis
Chapter283 UrinaryTractObstruction

Part13.DisordersoftheGastrointestinalSystem
Section1.DisordersoftheAlimentaryTract
Chapter284 ApproachtothePatientwithGastrointestinalDisease

LatestUpdate:
02/05/08:PostoperativeIleus:MastCellActivationand
InflammationMayBeKey

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Chapter285 GastrointestinalEndoscopy
Chaptere25 VideoAtlasofGastrointestinalEndoscopy
Chapter286 DiseasesoftheEsophagus

LatestUpdate:
05/27/08:EosinophilicEsophagitis:AnIncreasingly
PrevalentDisease
Chapter287 PepticUlcerDiseaseandRelatedDisorders

LatestUpdate:
10/02/07:OntheLongtermSafetyofProtonPump
Inhibitors
Chapter288 DisordersofAbsorption
Chapter289 InflammatoryBowelDisease

LatestUpdate:
07/08/08:ColitisAssociatedColonCancer:ThePotential
PathogenicRoleofTumorNecrosisFactor
Chapter290 IrritableBowelSyndrome
Chapter291 DiverticularDiseaseandCommonAnorectalDisorders

LatestUpdate:
02/05/08:PostoperativeIleus:MastCellActivationand
InflammationMayBeKey
Chapter292 MesentericVascularInsufficiency
Chapter293 AcuteIntestinalObstruction
Chapter294 AcuteAppendicitisandPeritonitis

Section2.LiverandBiliaryTractDisease
Chapter295 ApproachtothePatientwithLiverDisease
Chapter296 EvaluationofLiverFunction
Chapter297 TheHyperbilirubinemias
Chapter298 AcuteViralHepatitis

LatestUpdate:
11/18/08:HotTopic:FDAApprovesDNATesttoMeasure
HepatitisBVirusLevels
Chapter299 ToxicandDrugInducedHepatitis
Chapter300 ChronicHepatitis

LatestUpdate:
12/09/08:HotTopic:ChronicHepatitisC:AReassessment
ofLongTermTreatment
Chapter301 AlcoholicLiverDisease
Chapter302 CirrhosisandItsComplications

LatestUpdate:
02/12/08:CannabisUseontheSeverityofHepatitisC
Disease
Chaptere26 AtlasofLiverBiopsies
Chapter303 Genetic,Metabolic,andInfiltrativeDiseasesAffecting

theLiver
Chapter304 LiverTransplantation
Chapter305 DiseasesoftheGallbladderandBileDucts

Section3.DisordersofthePancreas
Chapter306 ApproachtothePatientwithPancreaticDisease
Chapter307 AcuteandChronicPancreatitis

Part14.DisordersoftheImmuneSystem,ConnectiveTissue,and

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Joints
Section1.TheImmuneSysteminHealthandDisease
Chapter308 IntroductiontotheImmuneSystem
Chapter309 TheMajorHistocompatibilityComplex
Chapter310 PrimaryImmuneDeficiencyDiseases
Chaptere27 PrimaryImmunodeficienciesAssociatedwithor

SecondarytoOtherDiseases
Section2.DisordersofImmuneMediatedInjury
Chapter311 Allergies,Anaphylaxis,andSystemicMastocytosis
Chapter312 AutoimmunityandAutoimmuneDiseases
Chapter313 SystemicLupusErythematosus
Chapter314 RheumatoidArthritis
Chapter315 AcuteRheumaticFever
Chapter316 SystemicSclerosis(Scleroderma)andRelated

Disorders
Chapter317 Sjgren'sSyndrome
Chapter318 TheSpondyloarthritides
Chapter319 TheVasculitisSyndromes

LatestUpdate:
12/05/07:CharacterizationofaLargeSeriesofPatientswith
PrimaryCentralNervousSystemVasculitis
Chaptere28 AtlasofClinicalImagingoftheVasculiticDiseases
Chapter320 Behet'sSyndrome
Chapter321 RelapsingPolychondritis
Chapter322 Sarcoidosis
Chapter323 FamilialMediterraneanFever
Chapter324 Amyloidosis

Section3.DisordersoftheJointsandAdjacentTissues
Chapter325 ApproachtoArticularandMusculoskeletalDisorders
Chapter326 Osteoarthritis
Chapter327 GoutandOtherCrystalAssociatedArthropathies
Chapter328 InfectiousArthritis

LatestUpdate:
02/07/08:SonicationofExplantedHipandKneeProstheses:
GreaterSensitivityThanPeriprostheticTissueCulturefor
DiagnosisofInfection
Chapter329 Fibromyalgia

LatestUpdate:
10/16/07:RepetitiveTranscranialMagneticStimulationMay
BeEffectiveforPaininFibromyalgia
Chapter330 ArthritisAssociatedwithSystemicDiseaseandOther

Arthritides
Chapter331 PeriarticularDisordersoftheExtremities

Part15.EndocrinologyandMetabolism
Section1.Endocrinology
Chapter332 PrinciplesofEndocrinology
Chapter333 DisordersoftheAnteriorPituitaryandHypothalamus
Chapter334 DisordersoftheNeurohypophysis

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Chapter335 DisordersoftheThyroidGland
Chapter336 DisordersoftheAdrenalCortex
Chapter337 Pheochromocytoma
Chapter338 DiabetesMellitus

LatestUpdate:
08/04/08:HotTopic:IntensiveGlucoseControlDoesNot
ImproveCardiovascularOutcomes
Chapter339 Hypoglycemia
Chapter340 DisordersoftheTestesandMaleReproductiveSystem

LatestUpdate:
04/30/08:MultigenicCausesofHypogonadotropic
Hypogonadism
Chapter341 TheFemaleReproductiveSystem:Infertilityand

Contraception
Chapter342 TheMenopauseTransitionandPostmenopausal

HormoneTherapy
Chapter343 DisordersofSexDevelopment
Chapter344 EndocrineTumorsoftheGastrointestinalTractand

Pancreas
Chapter345 DisordersAffectingMultipleEndocrineSystems

Section2.DisordersofBoneandMineralMetabolism
Chapter346 BoneandMineralMetabolisminHealthandDisease
Chapter347 DiseasesoftheParathyroidGlandandOtherHyper

andHypocalcemicDisorders
Chapter348 Osteoporosis

LatestUpdate:
05/20/08:ManagementofGlucocorticoidInduced
Osteoporosis
Chapter349 PagetDiseaseandOtherDysplasiasofBone

Section3.DisordersofIntermediaryMetabolism
Chapter350 DisordersofLipoproteinMetabolism
Chapter351 Hemochromatosis

LatestUpdate:
09/19/07:Hemochromatosis:PotentialUseofProtonPump
InhibitorsToReducetheFrequencyofPhlebotomies
Chapter352 ThePorphyrias
Chapter353 DisordersofPurineandPyrimidineMetabolism
Chapter354 WilsonDisease
Chapter355 LysosomalStorageDiseases
Chapter356 GlycogenStorageDiseasesandOtherInherited

DisordersofCarbohydrateMetabolism
Chapter357 HeritableDisordersofConnectiveTissue
Chapter358 InheritedDisordersofAminoAcidMetabolisminAdults
Chapter359 InheritedDefectsofMembraneTransport
Chaptere29 AtlasofClinicalManifestationsofMetabolicDiseases

Part16.NeurologicDisorders
Section1.DiagnosisofNeurologicDisorders
Chapter360 MechanismsofNeurologicDiseases
Chapter361 ApproachtothePatientwithNeurologicDisease

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Chapter362 NeuroimaginginNeurologicDisorders

LatestUpdate:
11/13/07:BrainMRICommonlyRevealsIncidentalFindings
Chaptere30 AtlasofNeuroimaging
Chaptere31 ElectrodiagnosticStudiesofNervousSystemDisorders:

EEG,EvokedPotentials,andEMG
Chaptere32 TechniqueofLumbarPuncture

Section2.DiseasesoftheCentralNervousSystem
Chapter363 SeizuresandEpilepsy

LatestUpdate:
11/03/08:AntiepilepticDrugsLeadtoBoneLossinMen
Chapter364 CerebrovascularDiseases

LatestUpdate:
11/04/08:HotTopic:AdmissionINRInverselyAssociated
withInfarctVolumeinIschemicStroke
Chapter365 Dementia
Chapter366 Parkinson'sDiseaseandOtherExtrapyramidal

MovementDisorders
LatestUpdate:
04/23/08:ParkinsonisminUsersofMethcathinoneLikely
RelatedtoManganese
Chapter367 HyperkineticMovementDisorders
Chapter368 AtaxicDisorders
Chapter369 AmyotrophicLateralSclerosisandOtherMotorNeuron

Diseases
Chapter370 DisordersoftheAutonomicNervousSystem
Chapter371 TrigeminalNeuralgia,Bell'sPalsy,andOtherCranial

NerveDisorders
LatestUpdate:
11/09/07:Prednisolone,butnotAcyclovir,Effectivefor
TreatmentofBellsPalsy
Chapter372 DiseasesoftheSpinalCord
Chapter373 ConcussionandOtherHeadInjuries
Chapter374 PrimaryandMetastaticTumorsoftheNervousSystem

LatestUpdate:
02/13/08:NegativeLanguageMappingTechnique
SuccessfulinDominantHemisphereBrainTumorSurgeries
Chapter375 MultipleSclerosisandOtherDemyelinatingDiseases

LatestUpdate:
11/25/08:AlemtuzumabisanEffectiveTherapyforEarly
MultipleSclerosis
Chapter376 Meningitis,Encephalitis,BrainAbscess,andEmpyema

LatestUpdate:
05/02/08:VaricellaZosterVirus(VZV)VasculopathyHas
DiverseClinicalandLaboratoryCharacteristics
Chapter377 ChronicandRecurrentMeningitis
Chapter378 PrionDiseases

Section3.NerveandMuscleDisorders
Chapter379 PeripheralNeuropathy

LatestUpdate:
08/11/08:ADetailedDescriptionofSmallFiberNeuropathy
Chapter380 GuillainBarrSyndromeandOtherImmuneMediated

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Neuropathies
LatestUpdate:
09/11/07:SystematicReviewofImmunotherapiesfor
GuillainBarrSyndrome
Chapter381 MyastheniaGravisandOtherDiseasesofthe

NeuromuscularJunction
LatestUpdate:
09/03/08:MycophenolateMofetilNotMoreEffectivethan
PrednisoneinMyastheniaGravis
Chapter382 MuscularDystrophiesandOtherMuscleDiseases

LatestUpdate:
09/19/08:PolymorphismIdentifiedthatIncreasesRiskof
StatinInducedMyopathy
Chapter383 Polymyositis,Dermatomyositis,andInclusionBody

Myositis
Chaptere33 SpecialIssuesinInpatientNeurologicConsultation

LatestUpdate:
07/09/08:CABGSurgeryNotLinkedtoCognitiveDecline
Section4.ChronicFatigueSyndrome
Chapter384 ChronicFatigueSyndrome

Section5.PsychiatricDisorders
Chapter385 BiologyofPsychiatricDisorders
Chapter386 MentalDisorders

LatestUpdate:
12/10/08:DepressioninCoronaryHeartDiseaseMaybe
ExplainedbyPhysicalInactivity
Section6.AlcoholismandDrugDependency
Chapter387 AlcoholandAlcoholism
Chapter388 OpioidDrugAbuseandDependence
Chapter389 CocaineandOtherCommonlyAbusedDrugs
Chapter390 NicotineAddiction

Part17.Poisoning,DrugOverdose,andEnvenomation
Chaptere34 HeavyMetalPoisoning
Chaptere35 PoisoningandDrugOverdosage
Chapter391 DisordersCausedbyReptileBitesandMarineAnimal

Exposures
Chapter392 EctoparasiteInfestationsandArthropodBitesand

Stings
Part18.eChaptersfromInternationalAdvisoryEditors
Chaptere36 PulmonaryBiomarkersinCOPD
Chaptere37 Chagas'Disease:AdvancesinDiagnosisand

Management
Chaptere38 ThePolypill
Chaptere39 MitochondrialDNAandHeritableTraitsandDiseases

Appendix:LaboratoryValuesofClinicalImportance

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