Beruflich Dokumente
Kultur Dokumente
Tutorial assignment 2
Due date: Wednesday, Dec. 3rd at 4:00 pm
Drop in LSB drop boxes Bio 2C03
Objectives:
Be able to:
research scientific literature and find the relevant article
use the knowledge acquired in class to understand and answer questions related to the research article
use correctly in-text citation and references style AMA style
Outline: Please read the following news article and find the original research paper referred to in the article. Read
the original research article and answer the following questions. When answering the questions use appropriate
in text citation and AMA reference style. You can use 3-5 references (textbook and research articles) to answer
the following questions.
Questions:
1. What is the title of the research paper that the news article is referring to? Provide a complete reference
indicating authors, date of publication, and journal. Use the AMA referencing style. (1 marks)
2. Why did the authors study this subject? (2 marks)
3. What is SGOL1 and what is its role at cellular level? What is the structure of sgol1? (3 marks)
4. Briefly explain how did they determine that mutations in sgol1 causes CAID syndrome? (6 marks)
5. What is morpholino-induced knockdown and why was used in this study? Briefly explain the technique. (4
marks)
6. What is Hoechst and why was used in this study? (1 mark)
7. Referring to figure 2a-f, what techniques were used and what these data show? (6 marks)
a.
b.
c.
d.
e.
f.
Technique:
8. Provide at least two other approaches the authors could undertake to improve on this study? (2 marks)