Contra Egg allergy (Vaccine may contain residual egg protein)

2) MMR (Measles, Mumps, Rubella)

(Attenuvax)
Class: Live Attenuated

A) Live Attenuated Vaccines

Mechanism:
Stimulates organism to produce Antibody
o Given as Two Doses: (Efficacy Reduced if age <1
year)
Dose 1:
12-15 months
Dose 2:
4-6 years
Indications:
Persons who have not had the disease
Persons who are recommended based on age/time since
last vaccination
Contraindications:
History of anaphylaxis to Neomycin or Egg Protein
Immunocompromised Individuals; Symptomatic HIV
Pregnancy

1) Influenza Type A/B (Flumist, Fluarix)

Side Effects:
Erythema & Induration at Site of Administration

Classes:
Live Attenuated (LAIV)
Killed Inactivated (Trivalent; TIV), Contains H1N1 Vaccine
Reassortment Vaccine
Indication (Yearly Admin):
Age 6mos-18yrs & 50+
Residents of Chronic Care Facilities; Healthcare Personnel
Patients with other Chronic Illnesses
Contents:
Inactivated form contains Hemagglutinin from viruses
likely to circulate
Made from highly purified, egg-grown, non-infectious
viruses
Side Effects:
Soreness at injection site; Fever, Malaise, Myalgias for 12 days
Risk of Guillain-Barre Syndrome

3) Varicella (Varivax)
Class: Live Attenuated
Indications:
Single Dose for Children age 1-13 (otherwise 2 Doses, 1
month apart)
Notes:
Protective efficacy is high
Note: Non-immunized adult population soon to be at risk

6) Yellow Fever (YF-Vax)

4) Herpes Zoster (Zostavax)
Class: Live Attenuated
Indication:
Immunization against Shingles
Indicated in persons >60 years

Class: Live Attenuated

Indications:
1. Travelers
Side Effects:
2. Headaches, Myalgia
3. Rare: Neurotropic Disease, Viscerotropic Disease

7) Typhoid (Vivotif , Live Oral Ty21A) (Typhim

5) Smallpox (Dryvax)
Class: Live Attenuated

Vi, killed)
Classes:
Live Attenuated (Oral; Bacterial)
Purified Protein/Polysaccharide (Typhim Vi)
Indications:
Travelers

1) Hepatitis A (Twinrix)
8) Bacile Calmette-Guerin (BCG)
Class: Live Attenuated (Bacterial)

Class: Killed (Inactivated)

Indications:
Sexual Contact with Individuals who have Hepatitis A
Persons who use Street Drugs
Travelers

2) Poliomyelitis
Enhanced Inactivated Polio Vaccine or
IPV (Pediarix)
B) Killed (Inactivated) Vaccines

Class: Killed (Inactivated)

Mechanism:
Originally less effective than OPV, but prevented Vaccineinduced paralysis
Enhanced IPV is equally effective to OPV
o 2 Doses: 90% Immunity; 3 Doses: 99% Immunity

3) DTaP

(Tetanus, Diptheria toxoid, and Acellular Pertussis)

(Daptacel, Pediarix)

Class: Killed (Inactivated)

Mechanism:
Stimulates organism to produce Antibody
Indications:
Persons without the disease who meet recommendation
based on age/time since previous vaccination

C) Purified Protein/Polysaccharide Vaccines

Contraindications:
Pregnancy
Note: Td can be given in 2nd/3rd Trimester
Side Effects:
Erythema & Induration at site of administration

4) Tdap

(Tetanus, Reduced Diptheria Toxoid, and

Acellular Pertussis) (Adacel)

1) Hepatitis B (Engerix-B, Twinrix)

Classes:
Purified Protein/Polysaccharide (Plasma Derived)
Genetically Engineered
Mechanism:
Contains Hep B Surface Antigen (HBsAg) from
recombinant Yeast Cells
Indications:
IM injection into deltoid (buttocks contraindicated)
Routine testing for immunity not required
Non-Response observed in:
o Males, Individuals >40, Smokers, Individuals with
Chronic Illness

2) Pneumococcal Conjugate Vaccine

(Prevnar,

Pneumovax 230)
7-Valent (Prevnar): Children
Class: Purified Protein/Polysaccharide (Bacterial)
Mechanism:
o Conjugated to Modified Diphtheria Toxin
o Administer to children < two at 2, 4, 6, & 12-15
months of age
o Administer one dose to Children over 2-5 years
90% effective in preventing all infections (6% for Otitis
Media)
23-Valent (Pneumovax): Adults/Children
Indication: (Single Dose)
o All adults >65
o Adults & Children >2 with Chronic Pulmonary
Disease
o Immunocompromised individuals

Quadrivalent Polysaccharide Vaccine

Safe and Effective against Serogroups C, Y, W-135, & A
Not protective against Serogroup B

Contraindications:
Children <2 years

4) Haemophilus Influenzae Type B

(HibTiter)
Class: Purified Protein/Polysaccharide (Bacterial)
Mechanism:
Contains inactivated H. flu w/ Polyribosyl Ribitol
Phosphate conjugated to:
o Tetanus Toxin (PRP-T)
o Outer Membrane Protein Complex of N.
meningitides (PRP-OMP)
o Mutant Nontoxic Diptheria Toxin (HbOC)
Effective at age 2mo.

3) Meningococcus (Menomune A/C/Y/W135, Menactra)

Class: Purified Protein/Polysaccharide (Bacterial)
Indications:
College freshmen, especially those who live in residence
halls
Meningitis belt of Sub-Saharan Africa, Nepal, Asia
Mechanism:

D) Genetically Engineered & Reassortment Vaccines

2) Rotavirus (RotaTeq)
Class: Reassortment Vaccine
Mechanism
Grown from a Bovine Rotavirus Strain

1) Human Papilloma virus (Gardasil)

Class: Genetically Engineered
Mechanism:
Contains Viral Shell Proteins grown in Yeast

*Vaccines for International Travelers*

4.
5.
6.
7.
8.
9.

Influenza
Hepatitis A
Hepatitis B
Typhoid
Cholera
Yellow Fever