Fibrosis

Thursday23October 2014

09:12

Inappropriatewoundhealingresponsecausesfibrosis
Fibroblastmoveintoawoundandhelpclosethewound
Skincellsthenreepithelialise theskin resistancetoinfection
buildsupagainwiththisbarrier
Toomuchcollageninthewoundhealingprocess keloid
scarring

Alveolarwallcontainsmanycapillaries thereisalsoathinlayer
ofepithelialcells,asmalllayerofcollagen
Ifthethicknessbuildsupeffectivegasexchangecannotoccur
Ifthealveoliarecontinuallydamagedfrominhalingparticlesa
buildupofcollagencanoccur
Fibroticlungisatvariousdifferentstagesthroughoutthelung
Bythetimesymptomsoccurtheinflammationisalreadythere
Emphysema degradationofthecollageninthelung

Nowaytoreversethescarring
HEARTFAILURE
Heartattack whenanareaoftheheartisstarvedofoxygen.
Usuallycausedbyaruptureofplaquedeposits
Fattydepositsinthebloodvesselsbloodvesselseesthisasan
injuryanditcausesthevesseltothicken
Athrosclorosisisaprecursortoheartattackorstrokewhichcan
kill.Thediseaseitselfisnotwhatkills
Dependingonthevesselsdamagedheartmusclesaredamaged
duetolackofoxygen
Systolicheartfailure alotofmusclelost,heartisweakened
Cardiacfibrosis
DiastolicheartfailureDHF
Diastoleiswhentheheartisrelaxed
Iftissuebecomesfibroticthecomplianceofthetissuereduces,
notasstretchy
Heartcanstillpumpbutcannotrelax aswellasnormal.
Lessbloodperbeat,cannotrelaxenoughtofillittoitsnormal
capacity
Lungscanalsofillwithfluidduetopoorcirculation sleep
sittingup
Onlyrecentlylabelledanddescribed
MorepatientsnowbeingidentifiedanddiagnosedwithDHFas
cliniciansnowunderstandmoreaftertheresearch
DiastolicdisfunctionispartofageinghowevertheDHFisa
seriousprogression
Highbloodpressuremeansanincreasedresistanceinthe
bloodvessels
Egifvesselsbegintorestrict
Sympatheticandparasympatheticnervoussystems
Whenstressedadrenalinepathwayturnedonslightlytherefore
bloodisdirectedtocertainareasofthebody,vasoconstriction
occurs
Organsaren'tgettingenoughblood,heartworksharder
collagendepositionincreases
Thenbecomesastiffmuscle
Hypertensiondrivenbylifestyle

RESEARCH
Aimstoimprovediagnosis,usesbiomarkers.Takesbloodfrom
patientswithdifferenttypesofheartfailure.Useultrasound,
goodwayofdiagnosingDHF.Notmanyechomachines,
cardiologistmustrefer.Longprocessbeforeacleardiagnosis.
Exercise clearlyhelp,improvecardiacfunction
Diabeticcardiomyopathy type2diabetesusuallyassociated
withitandDHF
Biomarkers bloodtesttryingtobefoundtobeusedbyGPs
thatcouldindicatethattheseissuesareoccurring
TRidentifyproblem,workwithclinicianstoseewhatunmet
needis.Workwithhumanserum,patientsamples,humancells.
Difficulties:hardtogethealthytissuefrompeople
Alsouseanimalmodelsofthesituationtofindnewtherapies.
Goaltofindadiagnostictestandthenacure.