6/24/2014

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Dealing with Contact

Dermatitis
Allergen Components
(Found in)

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TEST

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Dermatitis

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Allergen Components (Found In)

1. Nickel sulphate

Patch Testing
Interpretation of Patch Test
Results

Concentration:

0.20 mg/cm

Allergen component per patch:

Nickel, 0.036 mg

Vehicle:

Hydroxypropyl cellulose

Other substances to which the

patient may react:

Cobalt, chromium, disulfiram

Found in:

Jewelry, metal, and metal-plated objects;

occasionally in eye cosmetics

2. Wool alcohols (lanolin)

Concentration:

1.00 mg/cm

Allergen component per patch:

Cholesterol, lanosterol, agnosterol (and dihydro

derivatives); straight- and branched-chain aliphatic
alcohols; 0.81 mg total (the active allergenic
component has not been identified)

Vehicle:

Polyvidone

Synonyms and/or
components:

Lanolin, anhydrous lanolin, wool fat, wool wax,

wool grease, ClearlinTM, GlossylanTM, Golden
Dawn, HycholTM, NodorianTM, SparklelanTM,
adeps lanae anhydrous, aloholes lanae
Also modified lanolins, such as lanolin aid, lanolin
alcohol, lanolin oil, lanolin wax, Amerchol L-101,
and Amerchol CAB

Other substances to which the

patient may react:

Eucerin, Aquaphor

Found in:

Cosmetics, soaps, and topical medications

3. Neomycin sulphate
Concentration:

0.023 mg/cm

Allergen component per patch:

Neomycin sulfate, USP, 0.19 mg

Vehicle:

Methylcellulose

Synonyms and/or
components:

Gentamicin sulfate, bacitracin, kanamycin,

streptomycin sulfate injection, spectinomycin HCl,
tobramycin sulfate

Found in:

Topical antibiotics

4. Potassium dichromate
Concentration:

0.023 mg/cm

Allergen component per patch:

Chromium, 0.0067 mg

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Vehicle:

Hydroxypropyl cellulose

Synonyms and/or
components:

Chromium, chrome, chromate, chromite

Found in:

Cement, chrome-tanned leather, welding fumes,

cutting oils, antirust paints, other industrial
chemicals

5. Caine mix
Concentration:

0.63 mg/cm

Allergen component per patch:

Benzocaine, USP, 0.364 mg; tetracaine HCl,

USP, 0.063 mg; dibucaine HCl, USP, 0.064 mg

Vehicle:

Polyvidone

Synonyms and/or
components:

Benzocaine: ethyl aminobenzoate, paminobenzoic, acid (PABA) ethyl ester,

Aethoform, Americaine, Anesthesin,
Anesthane, Orthesin, Parathesin,
Anesthone
Tetracaine HCl: tetracaine, Pontocaine
Dibucaine HCl: dibucaine, Nupercaine

Other substances to which the

patient may react:

Benzoic acid derivatives:

PABA esters: procaine, benoxinate HCl,
butamben picrate, butacaine, butethamine HCl,
naepaine, orthocaine, propoxycaine, risocaine,
chloroprocaine HCl
m-Aminobenzoic acid esters: metabutethamine,
proparacaine
Benzoic acid esters: cocaine HCl, amylocaine,
benzamine, cyclomethycaine, meprylcaine HCl,
metabutozycaine, piperocaine HCl, hexylcaine
HCl, proparacaine HCl
Other agents: Procainamide, hydrochlorothiazide,
PABA and PABA ester sunscreens, Azo and
aniline dyes, p-phenylenediamine, sulfonamides,
sulfonylureas, p-aminosalicylic acid

Found in:

Topical anesthetics

6. Fragrance mix
Concentration:

0.43 mg/cm

Allergen component per patch:

Geraniol, 0.070 mg; cinnamaldehyde, 0.034 mg;

hydroxycitronellal, 0.054 mg; cinnamyl alcohol,
0.054 mg; eugenol, 0.034 mg; isoeugenol, 0.015
mg; amylcinnamaldehyde, 0.015 mg; oak moss,
0.070 mg

Vehicle:

Hydroxypropyl cellulose, cyclodextrin

Synonyms and/or
components:

Synonyms: cologne, toilet water, perfume,

masking or unscented perfume or fragrance,
aroma chemicals, essential oils of plants and
animals.
Individual fragrance allergens: cinnamic alcohol,

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cinnamic aldehyde, oak moss absolute,

amylcinnamic alcohol, anisyl alcohol, benzyl
alcohol, benzyl salicylate, coumarin, sandalwood
oil, musk ambrette, wood tars
Other substances to which the
patient may react:

Balsam of Peru, ethylene bassylate (Musk T),

cloves, cinnamon, cassia oil, citronella candles

Found in:

Fragrances, toiletries, scented household

products, flavorings, food, industrial products

7. Colophony
Concentration:

0.85 mg/cm

Allergen component per patch:

Colophony, 0.69 mg

Vehicle:

Polyvidone

Synonyms and/or
components:

Rosin, resina terebinthinae, gum rosin, rosin gum,

W-W wood rosin, tall oil, abietic acid, methyl
abietate alcohol, abietic alcohol, abietyl alcohol,
Dertomal 18, Abitol, Hercolyn D, Foral
105, Staybelite 10, Granolite SG, Dercolyte
ZS, Dertophene 18

Other substances to which the

patient may react:

Wood tars, other coniferous trees, other plant

materials including Chrysanthemum, some
spices, fragrances, oils

Found in:

Cosmetics, adhesives, a variety of household and

industrial products

8. Epoxy resin
Concentration:

0.050 mg/cm

Allergen component per patch:

Diglycidylether of bisphenol A, 0.032 mg

Vehicle:

Hydroxypropyl cellulose

Synonyms and/or
components:

4,4'-Isopropylidenediphenol-epichlorohydrin,
diglycidyl ether, bisphenol A [2,2-bis(4hydroxyphenyl)propane] (diphenylpropane),
epichlorohydrin (1-chloro-2,3-epoxypropane) (8chloropropylene oxide)

Other substances to which the

patient may react:

The hardening agent of a two-part adhesive,

specifically components such as ethylenediamine

Found in:

Two-part adhesives, surface coatings, paints

9. Quinoline mix
Concentration:

0.190 mg/cm

Allergen component per patch:

Clioquinol: 0.077 mg, Clorquinaldol: 0.077 mg

Vehicle:

Polyvidone

Synonyms and/or
components:

5-chloro-7-iodo-8-hydroxyquinoline
5,7-dichloro-8-2-methylquinoline

Other substances to which the

patient may react:

Vioform, chlorquinaldol quinoform, entroquinol,

sterosan, quinaband, iodinechloridequinoline.
Enterovioform (R)

Found in:

Paste bandages, medicated creams and oinments

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10. Balsam of Peru

Concentration:

0.80 mg/cm

Allergen component per patch:

Balsam of Peru, 0.65 mg total

Vehicle:

Polyvidone

Synonyms and/or
components:

Synonyms: balsamum peruvianim, Peruvian

balsam, Indian balsam, China oil, black balsam,
Honduras balsam, Surinam balsam
Components or chemically related allergens:
Cinnamic acid, benzyl salicylate, vanillin, benzoic
alcohol, benzyl acetate, benzaldehyde, benzyl
benzoate and other benzoates, benzoic acid,
cinnamic alcohol, cinnamic aldehyde, cinnamyl
cinnamate, methylcinnamate, eugenol,
isoeugenol, coniferyl alcohols, resinous
substances.

Other substances to which the

patient may react:

Cinnamein (essential oil), oil of cinnamon, tincture

of krameria, balsam of Copaiba, storax (styrax),
essence of orange peel, spices (e.g., Jamaican
pepper, cinnamon, cloves, nutmeg, paprika, curry,
vanilla), Tiger Balm (oriental), benzoin tincture
(gum benzoin), wood tars, colophony, balsam of
Tolu, turpentine, beeswax, coumarin,
diethylstilbestrol, propolis

Found in:

Foods, cosmetics, fragrances, flavorings, topical

medications

11. Ethylenediamine dihydrochloride

Concentration:

0.050 mg/cm

Allergen component per patch:

Ethylenediamine, 0.018 mg

Vehicle:

Methylcellulose

Synonyms and/or
components:

1,2-Ethanediamine, 1,2-diaminoethane,
chlorethamine

Other substances to which the

patient may react:

Aminophylline, hydroxyzine, piperazine-based

antihistamines (meclizine, buclizine,
chlorcyclizine, cyclizine), tripelennamine,
promethazine HCl, epoxy resin catalysts
(ethylenediamine and chemically related amines
such as diethylenediamine, dipropylenetriamine,
triethylenetetramine, tetraethylenetetramine,
trimethylhexamethylenediamine)

Found in:

Topical medications, eyedrops, industrial solvents,

anticorrosive agents

12. Cobalt dichloride

Concentration:

0.020 mg/cm

Allergen component per patch:

Cobalt, 0.0040 mg

Vehicle:

Hydroxypropyl cellulose

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Synonyms and/or
components:

Cobalt blue, cobaltous (modifying any word)

Alloys containing cobalt:

Stellite, Vitallium, Alnico, Durlium,

Mobilium, Permalloy, Ticonium, Wolfram
carbide

Other substances to which the

patient may react:

Nickel, chromate

Found in:

Metal-plated objects, paints, cement, vitamin B12

13. p-tert-butylphenol formaldehyde resin

Concentration:

0.050 mg/cm

Allergen component per patch:

p-tert-Butylphenol formaldehyde, 0.041 mg

Vehicle:

Hydroxypropyl cellulose

Synonyms and/or
components:

Paratertiary butylphenol formaldehyde resin, PTBP

formaldehyde, butylphen, 4(1,1dimethylethyl)phenol

Other substances to which the

patient may react:

Degaplast glue, neoprene adhesives

Found in:

Waterproof glues, bonded leather, construction

materials, paper, fabrics

14. Paraben mix

Concentration:

1.00 mg/cm

Allergen component per patch:

Methyl p-hydroxybenzoate, 0.162 mg;

ethyl p-hydroxybenzoate, 0.162 mg;
propyl p-hydroxybenzoate, 0.162 mg;
butyl p-hydroxybenzoate, 0.162 mg;
benzyl p-hydroxybenzoate, 0.162 mg;

Vehicle:

Polyvidone

Synonyms and/or
components:

Methylparaben, ethylparaben, propylparaben,

butylparaben, p-hydroxybenzoate, phydroxybenzoic acid, Nipagin, Perservaben,
Protaben, Aseptoform, Lexgard, Parasept,
Liqua Par, Germaben II (mixture), Nipastat
(mixture), Phenonip (mixture), undebenzofene-C
(mixture)

Other substances to which the

patient may react:

p-Aminobenzoic acid (PABA) esters, pphenylenediamine (rarely)

Found in:

Preservative in topical formulations, cosmetics,

foods, industrial preparations

15. Carba mix

Concentration:

0.25 mg/cm

Allergen component per patch:

Diphenylguanidine, 0.067 mg;

zincdibutyldithiocarbamate, 0.067 mg;
zincdiethyldithiocarbamate, 0.067 mg;

Vehicle:

Hydroxypropyl cellulose

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Synonyms and/or
components:

Carbamate, carbanilate, 1,3diphenylguanidine/(DPG, Nocceler D,

Sanceler D, Soxinol D),
zincdibutyldithiocarbamate (ZBC, butazin, butyl
zimate, Nocceler BZ, Soxinol BZ, Butazate,
Butasan), zincdiethyldithiocarbamate (ZDC,
ZDEC, Etazin, Ethasan, ethyl zimate,
Nocceler EZ, Soxinol EZ, Ethazate)

Other substances to which the

patient may react:

Thiuram mix, mercapto mix,

mercaptobenzothiazole, disulfiram (Antabuse).

Found in:

Rubber products, glues for leather, pesticides,

vinyl, soaps, shampoos, disinfectants

16. Black rubber mix

Concentration:

0.075 mg/cm

Allergen component per patch:

N-Isopropyl-N'-phenyl paraphenylenediamine,
0.0102 mg; N-cyclohexyl-N'-phenyl
paraphenylenediamine, 0.0255 mg; N,N'-diphenyl
paraphenylene-diamine, 0.0255 mg

Vehicle:

Polyvidone

Synonyms and/or
components:

N-Phenyl-N'-cyclohexyl-p-phenylenediamine
(CPPD): phenylcyclohexyl PPD, Flexzone GH
N-Isopropyl-N'-phenyl-p-phenylenediamine (IPPD):
isopropyl 0 PPD, Akrochem Antioxidant PD1,
ANTO'H', Flexzone 3-C, Permanex IPPD,
Santoflex IP
N,N'-Diphenyl-p-phenylenediamine (DPPD):
Diphenyl PPD

Other substances to which the

patient may react:

Hair dye chemicals: p-aminodiphenylamine, pphenylenediamine

Found in:

All black rubber products, some hair dyes

17. Cl+ Me- Isothiazolinone

Concentration:

0.0040 mg/cm

Allergen component per patch:

5-Chloro-2-methyl-4-isothiazolin-3-one, 0.0024 mg;

2-methyl-4-isothiazolin-3-one, 0.0008 mg

Vehicle:

Polyvidone

Synonyms and/or
components:

Methylchloroisothiazolinone (MCI),
methylisothiazolinone (MI), Kathon

Other substances to which the

patient may react:

Other isothiazolinones

Found in:

Cosmetics and skin care products, topical

medications, household cleaning products; as
Kathon in industrial products

18. Quaternium-15
Concentration:
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0.100 mg/cm
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Allergen component per patch:

Quaternium-15, 0.081 mg

Vehicle:

Hydroxypropyl cellulose

Synonyms and/or
components:

N-(3-chloroallyl)-Hexaminium chloride, cis-1-(3chloroallyl)-3,5,7-triaza-1-azonium-adamantane

chloride, 1-(3-chloroallyl)-3,5,7-triaza-1-azoniumadamantane chloride, Preventol D 1,
methanamine-3-chloroallylochloride, chloroallyl
methanamine chloride, Dowicil 75 (or 100 or
200), azonium-adamantane chloride

Other substances to which the

patient may react:

Formaldehyde:
Formaldehyde-releasing preservatives found in
cosmetics and topical agents: Germall 115
(imidazolidinyl urea), Germall II (diazolidinyl
urea), Glydant [DMDM (dimethylolmethyl)
hydantoin], Bronopol (2-bromo-2-nitropropane1,3-diol), Tris Nitro [tris (hydroxymethyl)
nitromethane]
Formaldehyde-releasing preservatives found in
industrial and metal-working fluids: Dowicil 75,
Tris Nitro, Grotan HD2, Grotan BK,
Triadine-10, Onyxide 200, Vancide TH,
Myacide BT

Found in:

preservative in cosmetics and skin care products,

household polishes and cleaners, industrial
products

19. Mercaptobenzothiazole
Concentration:

0.075 mg/cm

Allergen component per patch:

Mercaptobenzothiazole, 0.061 mg

Vehicle:

Polyvidone

Synonyms and/or
components:

MBT, 2-benzathiazalethiol, Captax, Dermacid,

Mertax, Thiotax, Nocceler M, Rotax

Other substances to which the

patient may react:

Mercapto mix, thiuram mix, carba mix

Found in:

Rubber products, adhesives, industrial products,

veterinary tick/flea sprays and powders, film
emulsion

20. p-Phenylenediamine
Concentration:

0.090 mg/cm

Allergen component per patch:

p-Phenylenediamine, 0.073 mg

Vehicle:

Polyvidone

Synonyms and/or
components:

Paraphenylenediamine (PPD or PPDA), 1,4benzenediamine, 1,4-phenylenediamine, Rodol

D, p-aminoaniline, Orsin, p-diaminobenzene,
Ursol D

Other substances to which the

patient may react:

PABA-based sunscreens or creams, other dye

chemicals, Azo or disperse textile dyes, paminosalicylic acid, black rubber products,

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diaminodiphenylmethane (epoxy hardener), ptoluenediamine, p-aminodiphenylamine, 2,4diaminoanisole, o-animophenol

Occasionally, 'sulfa' drugs (sulfonamides), 'caine'
drugs such as benzocaine
Found in:

Permanent (coal tar) or semipermanent hair dyes,

dyed textiles, cosmetics, printing ink,
photodeveloper

21. Formaldehyde
Concentration:

0.18 mg/cm

Allergen component per patch:

Formaldehyde, 0.15

Vehicle:

Polyvidone

Synonyms and/or
components:

Oxymethylene, methanal, formalin

Formaldehyde-releasing
preservatives:

Preservatives found in cosmetics and topical

agents: Quaternium-15, Germall 115
(imidazolidinyl urea), Germall II (diazolidinyl
urea), Glydant [DMDM(dimethylolmethyl)
hydantoin], Bronopol (2-bromo-2-nitropropane1,3-diol), Tris Nitro [tris (hydroxymethyl)
nitromethane]
Preservatives found in industrial and metal-working
fluids: Dowicil 75, Tris Nitro, Grotan HD2,
Grotan BK, Triadine-10, Onyxide 200,
Vancide TH, Myacide BT.

Found in:

Fabric finishes, cosmetics, plastics, synthetic

resins, glues, textiles, construction material

22. Mercapto mix

Concentration:

0.075 mg/cm

Allergen component per patch:

N-Cyclohexylbenzothiazyl-sulfenamide, 0.0203
mg; dibenzothiazyl disulfide, 0.0203 mg;
morpholinylmercaptobenzothiazole, 0.0203 mg

Vehicle:

Polyvidone

Synonyms and/or
components:

N-Cyclohexyl-2-benzothiazole-sulfenamide (CBTS,
CBS): cyclohexylbenzothiazyl-sulphenamide,
Durax, Santocure
Dibenzothiazyl disulfide: 2,2'-benzothiazyl
disulfide, Altax, Thiofide, Naugex MBT,
Vulkacit DM
Morpholinylmercaptobenzothiazole (MOR, MMBT):
4-morpholinyl-2-benzothiazyl disulfide

Other substances to which the

patient may react:

Mercaptobenzothiazole, carba mix, thiuram mix

Found in:

Rubber products, glues for leather and plastics,

industrial products

23. Thiomersal
Concentration:

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0.0080 mg/cm

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Allergen component per patch:

Thiomersal, 0.0065 mg

Vehicle:

Hydroxypropyl cellulose

Synonyms and/or components:

Merthiolate, Mercurochrome, sodium

ethylmercurithiosalicylate, mercurothiolate, merzonin,
mertorgan, merfamin, ethyl (2-mercaptobenzoato-S) mercury
(sodium salt), thiomersalate, thiomersal, thiomersalan, [(ocarboxyphenyl)thio] ethylmercury (sodium salt)

Other substances to w hich the

patient may react:

Other organic (not metallic) mercury compounds, piroxicam

(Feldene)

Found in:

Preservative in contact lens solutions, cosmetics, nose and

ear preparations, injectable drugs

24. Thiuram mix

Concentration:

0.025 mg/cm

Allergen component per patch:

Tetramethylthiuram monosulfide, 0.0051 mg;

tetramethylthiuram disulfide, 0.0051 mg;
disulfiram, USP, 0.0051 mg;
dipentamethylenethiuram disulfide, 0.0051 mg

Vehicle:

Polyvidone

Synonyms and/or
components:

Tetramethylthiuram monosulfide (TMTM)

Tetramethylthiuram disulfide (TMTD): Thiram,
thiurad, Thiosan, Thylate, Thiuramyl,
Tiuramyl, Puralin, Fernasan, Nomersan,
Rezifilm, Pomarsal, Tersan, Tuads,
Tulisan, Arasan
Disulfiram: Antabuse, bis(diethylthiocarbamoyl)
disulfide, tetraethylthiuram disulfide (TETD),
Cronetal, Abstenisil, Stopetyl, Contralin,
Robac TET, Antadix, Antiethanol, ethyl
thiurad, Etabus, Rosulfiram, Abstinyl,
Thiuranide, Tetradine, Noxal
Dipentamethylenethiuram disulfide (PTD):
Robac PTD

Other substances to which the

patient may react:

Mercapto mix, mercaptobenzothiazole, carba mix

Found in:

Rubber products, adhesives, pesticides, gloves,

drugs

25. Diazolidinyl urea

Concentration:

0.55 mg/cm

Allergen component per patch:

Diazolidinyl urea, 0.45 mg

Vehicle:

Polyvidone

Other substances to which the

patient may react:

Imidazolidinyl urea (Germall 115),

benzylhemiformal, Bronopol, Quarternium-15,
DMDM hydantoin, trimetylolnitromethan

Found in:

Cosmetics, shampoos and skin care products.

Liquid soaps, hair conditioners, gels, bubble
baths, baby wipes

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26. Imidazolidinyl urea

Concentration:

0.60 mg/cm

Allergen component per patch:

Imidazolidinyl urea, 0.49 mg

Vehicle:

Hydroxypropyl cellulose

Other substances to which the

patient may react:

Diazolidinyl urea (Germall II), benzylhemiformal,

bromonitropropanediol, Quarternium-15, DMDM
hydantoin, trimethylolnitromethan

Found in:

Cosmetics, shampoos and skin care products.

Liquid soaps, hair conditioners, gels, bubble
baths, baby wipes.

27. Budesonide
Concentration:

0.0010 mg/cm

Allergen component per patch:

Budesonide, 0.00081 mg

Vehicle:

Polyvidone

Other substances to which the

patient may react:

Amcinonide, desonide, flucloronide, flunisolide,

fluocinonide, halcinonide, procinonide,
triamcinolone

Found in:

In medications prescribed topically for eczema

and other local inflammations. Creams, lotions,
ointments, and powders. Ear, nose and eye drops
for rhinitis, otitis, and conjunctivitis

28. Tixocortol Pivalate

Concentration:

0.00300 mg/cm

Allergen component per patch:

Tixocortol Pivalate, 0.0024 mg

Vehicle:

Polyvidone

Other substances to which the

patient may react:

Hydrocortisone, prednisolone, fludrocortisone

acetate, methylprednisolone, cloprednol

Found in:

Creams, lotions, ointments, powders, ear, node

and eye drops for the treatment of eczema and
other local inflammations.

29. Hydrocortisone-17-butyrate
Concentration:

0.020 mg/cm

Allergen component per patch:

Hydrocortisone-17-butyrate, 0.016 mg

Vehicle:

Polyvidone

Other substances to which the

patient may react:

Hydrocortisone-17-aceponate, hydrocortisone-17buteprat, methylprednisolone aceponate,

prednicarbate

Found in:

Ezcema medication. Creams, lotions, ointments,

and powders. Ear, nose and eye drops for rhinitis,
otitis, and conjunctivitis

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