Beruflich Dokumente
Kultur Dokumente
STING/ENVENOMATION
Background
Medically
important
species
Pathophysiology
of
envenomation
Venom
blocks
the
inactivation
of
Na
channels
and
inhibits
the
K
channels.
The
stimulated
sodium
channels
and
the
inhibited
potassium
channels,
both
lead
to
intense,
persistent
stimulation
of
autonomic
nerves,
leading
to
massive
release
of
neurotransmitters
from
adrenal
medulla,
stimulating
parasympathetic
and
sympathetic
nerve
endings,
thus
initiating
Autonomic
storm
Closer
proximity
of
the
sting
to
the
head
and
torso
results
in
quicker
venom
absorption
into
the
central
circulation
and
a
quicker
onset
of
symptoms.
Labs:
(Limited
role,
not
for
diagnosis
but
to
look
for
complications)
1.
2.
3.
4.
5.
Treatment
1970-80s
During
s
Pre
prazosin
era
Lytic
Cocktail(chlorpromazine,
promethazine,
and
meperidine)
was
in
vogue
(not
recommended
anymore)
1.
2.
3.
4.
Prazosin
is
widely
used
for
management
of
Mesobuthus
Tamulus
sting.
It
is
the
physiological
and
pharmacological
antidote
for
scorpion
envenomation.
Further Reading:
1. Kale
AA.
A
Crusade
Against
Scorpion
Sting:
Life
and
Works
of
Dr.
Himmatrao
Bawaskar.
2.
3.
4.
5.
Questions/Comments/Feedback
Lakshay
Chanana
drlakshay_em@yahoo.com
EMDidactic
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