Sie sind auf Seite 1von 4

01/03/2015

Noni(Morindacitrifolia)|PlantProfiler|SigmaAldrich

Hello.Signin.

Life Science > Nutrition Research > Learning Center > Plant Profiler > Noni (Morinda citrifolia)

PlantProfiler

LifeScienceHome
LifeScienceProducts

0Items

Noni(Morindacitrifolia)
Synonyms / Common Names / Related Terms

ADME/Tox

Al,alizarin,alkaloids,americaninA,aminoacids,anthraquinone,anthraquinoneglycoside,asperuloside,asperulosidicacid,atchy(Hindi),
sitosterol,borreriagenin,cadapilva(Malay),caproicacid,caprylicacid,carotene,citrifolininBepimera,citrifolininBepimerb,citrifolinoside,
cytidine,deacetylasperuloside,dehydromethoxygaertneroside,dglucose,dilo'k(Pijin),dmannitol,epidihydrocornin,flavoneglycosides,
Indianmulberry,iridoidglycoside,kura(Fijian),kuti,ladda(Chamorro),Lasperuloside,linoleicacid,maddichettoo(Telugu),manjapavattay,
methylalphadfructofuranoside,methylbetadfructofuranoside,molagha,Morindacitrifolia,morindacin,morindone,murierd'Inde,najalanun,
nakura,narcissoside,nen(Chamorro),nicotifloroside,nolom,nono(CookIslandsMaori),nonu(Tongan,Wallisian,Futunian,Niuean,
Tokelauan,Tuvaluan),nonutogi(Samoan),noona(Tamil),nordamnacanthal,nowoi(Bislama),octanoicacid,potassium,riro(TokPisin),
proxeronine,Rubiaceae(family),rubiadin,rubiadin1methylether,rutin,scopoletin,tenon(Gilbertese),terpenoids,TNJ,ursolicacid,
vitaminA,vitaminC,yelotri.

CellBiology
CellsandCellBasedAssays
CellCulture
CoreBioreagents

Combinationproductexamples:TahitianNonijuice(nonifruitjuicefromjuicepuree,grapejuiceconcentrate,blueberryjuiceconcentrate,naturalflavors).

CustomOligos
Epigenetics
FunctionalGenomics&RNAi
GeneSearch

Mechanism of Action
Pharmacology:
Constituents:Variouscomponentshavebeenidentifiedinthenoniplant,suchasscopoletin,octanoicacid,potassium,vitaminC,
terpenoids,alkaloids,anthraquinones(suchasnordamnacanthal,morindone,rubiadin,rubiadin1methylether,anthraquinoneglycoside),
sitosterol,carotene,vitaminA,flavoneglycosides,linoleicacid,alizarin,aminoacids,Lasperuloside,caproicacid,caprylicacid,ursolic

Metabolomics

acid,rutin,andaputativeproxeronine.49,50,51,8,52,53,54,55,56,57,58,59,20,60Severalflavonolglycosideshavealsobeenidentified,including
aniridoidglycosidefromthenonileaves,atrisaccharidefattyacidester,rutin,twonovelglycosides,citrifolinoside,andanasperulosidicacid

MolecularBiology

fromthefruit.61,45,34,62,63,33,36Sixanthraquinones,including5,15Odimethylmorindol,andthreeiridoids,includingmorindacin,havealso

NutritionResearch
NutritionResearchProducts
LearningCenter

beenisolatedfromMorindacitrifoliafruits.1
ThemethanolextractofMorindacitrifoliafruitscontains6alphahydroxyadoxoside,6beta,7betaepoxy8episplendoside,americaninA,
narcissoside,asperuloside,asperulosidicacid,borreriagenin,citrifolininBepimersaandb,cytidine,deacetylasperuloside,
dehydromethoxygaertneroside,epidihydrocornin,dglucose,dmannitol,methylalphadfructofuranoside,methylbetadfructofuranoside,

FAQCategories

nicotifloroside,2methoxy1,3,6trihydroxyanthraquinone,andbetasitosterol3Obetadglucopyranoside.64,2
Analgesiceffects:AMorindacitrifoliaextractshowedasignificant,doserelated,centralanalgesiceffectinmice,whichwas75%asstrong

Metabolomics

asmorphine,yetnonaddictiveandsideeffectfree.12Inasimilarstudy,TahitianNonijuice(TNJ)hadadosedependentanalgesiceffect

PlantProfiler

onantimonypotassiumtartrateinducedpaininmiceandrats.11Inanaceticacidinducedwrithingtestinmice,thealcoholicextractof
Morindacitrifoliafruitshadadosedependentinhibitoryeffect,startingat4g/kg,whichwassimilartothatproducedbymorphineinadoseof

Proteomics
StemCellBiology
SyntheticBiology
TranslationalResearch
Solutions

1.5mg/kg.65Theantinociceptiveeffectinthewrithingtestwasstatisticallysignificant(p<0.001)for15minutesuntilfivehoursafter
administration.InaPhaseItrialincancerpatients,therewasastatisticallysignificant(t(35)=2.84,p=0.006)decreaseinpaininterference
afteraweekofnoniindosesof2,4,6,8,or10g.3
Anthelminticeffects:Inaninvitrostudy,anonileafethanolextractinducedparalysisanddeathofthehumanparasiticnematodeworm
Ascarislumbricoideswithin24hours.13
Antiangiogeniceffects:Noniatconcentrationsof>5%byvolumewashighlyeffectiveininhibitingtheinitiationofnewvesselsproutsfrom

ZincFingerNuclease(ZFN)

placentalveinexplants,and10%nonijuiceinmediawasaneffectiveinhibitorofcapillaryinitiationinexplantsfromhumanbreasttumors.14
Cardiovasculareffects:Theoxidativemodificationoflowdensitylipoprotein(LDL)playsanimportantroleinthegenesisofarteriosclerosis.

LearningCenter

AstudybyKamiyaetal.focusedontheeffectsofthefruitsofMorindacitrifoliaonpreventingarteriosclerosis.25TheMeOHextractand
CHCl3,EtOAc,nBuOH,andH2OsolublephasesderivedfromthefruitsofMorindacitrifoliawereevaluatedfortheirinhibitoryactivityon

Labware

copperinducedLDLoxidationbythethiobarbituricacidreactivesubstances(TBARS)method.TheMeOHextractandEtOAcsolublephase
showed88%and96%inhibitionrespectively.SixlignanswereisolatedbyrepeatedcolumnchromatographyfromtheEtOAcsolublephase:
3,3'bisdemethylpinoresinol,americanolA,americaninA,americanoicacidA,morindolinandisoprincepin.Thesecompoundsinhibited
copperinducedLDLoxidationinadosedependentmanner.1,2,5,and6exhibitedremarkablystrongactivities,whichwerethesameor
betterthanthatoftheknownantioxidant2,6ditertbutylpcresol.TheIC50valuesfor1,2,5,and6were1.057,2.447,2.020and1.362mcM,
respectively.Theactivityofthesecompoundsismainlyduetotheirnumberofphenolichydroxylgroups.Whennoni'spotentialtoinhibit
oxidationoflowdensitylipoprotein(LDL)invitroandtomodulateLDLreceptor(LDLr)activityinculturedHepG2cellswastested,LDLrwas
significantlyupregulated(p<0.05)bynoni(49%).66Inasimilarstudy,nonicausedinhibitionof14CincorporationinHepG2cells,(77%
comparedtocontrol).67However,thisdecreaseinincorporationcannotbeaccountedforbytheinhibitionofcholesterolsynthesisalone.The
proportionofcholesterolinthesampledecreasedfrom38%inthecontrolto28%inthepresenceofnoni:evidencethatsynthesisof
cholesterolwasinhibited.Aftertakingintoaccounttherelativedifferencesintotal14Cincorporation,nonicauseda26%inhibitionin
cholesterolsynthesis,comparedto55%inhibitionbythepositivecontrollovastatinhydroxyacid.Itcouldnotbeestablishedwhatcausedthe
overalldecreasein14Cincorporationinthepresenceofnoni,butitsmodeofactionwouldappeartobedifferenttothatoflovastatinhydroxy
acid.
Inanimalstudies,thetotalextractofthenonirootsandvariousnonirootextractshaveshownahypotensiveeffect,althoughthemechanism
forthiseffectisnotclear.5,6,7,8,9,10
Antibacterialeffects:Specificcompoundsfromvariouspartsofthenoniplanthavebeeneffectiveinlaboratorystudiesasantibacterial
agents,supportingthePolynesiantraditionalmedicinaluseforinfectiousdiseases.18,19Inaninvitrostudy,extractsfromtheripenonifruit,
includingLasperulosideandalizarin,exhibitedmoderateantibacterialpropertiesagainstPseudomonasaeruginosa,Micrococcus
pyrogenes,Escherichiacoli,Pseudomonasaeruginosa,Proteusmorgaii,Staphylococcusaureus,Bacillissubtilis,Salmonella,and
Shigela.16SomeanthraquinonecompoundsfromnonirootswerealsoeffectiveagainststrainsofPseudomonasaeruginosa,Proteus
morgaii,Staphylococcusaureus,Bacillissubtilis,Escherichiacoli,Salmonella,andShigela.15Specifically,thecompoundscopoletinfrom
noniinhibitstheactivityofEscherichiacoliandH.pylori.17Also,aconcentratednonileafextractkilled89%ofMycobacteriumtuberculosisin
atesttube,comparedtorifampin,aleadingantituberculosisdrug,whichhasaninhibitionrateof97%atthesameconcentration.20
Antiinflammatoryeffects:Invariousanimalandinvitrostudies,nonishowspromiseasanantiinflammatoryagent.Inaninvitrostudies,
TahitianNoniJuicehadcomparableselectivityofCOX2inhibitionascelecoxib(0.34)21andMorindacitrifoliafruitpowderexhibited
inhibitionofCOX1withtheIC50of163mc/mL,comparedtoaspirin(IC50=241mc/mL)andindomethacin(IC50=1.2mc/mL)22.Inanimal
studies,TahitianNonijuicedecreasedinflammatoryfociinanacuteliverinjuryratmodel23,andorallyandintraperitoneallyadministered
nonifruitjuiceextractreducedinflammationinbradykinininducedinflammationandcarrageenaninducedpawedema24.
Antioxidanteffects:InvitroTahitianNonijuice(TNJ)showedadosedependentinhibitionofbothlipidperoxidesandsuperoxideanion
radicalscomparabletograpeseedpowder.45,46,47Thisresultwassupportedbyaratliverinjurymodel,where10%TNJinthedrinking

http://www.sigmaaldrich.com/lifescience/nutritionresearch/learningcenter/plantprofiler/morindacitrifolia.html

1/4

01/03/2015

Noni(Morindacitrifolia)|PlantProfiler|SigmaAldrich
waterreducedlipidperoxidesandsuperoxideanionradicalsafterliverinjuryinduction.23Intermsofboth1,1diphenyl2picrylhydrazyl
(DPPH)andperoxynitrite(ONOO())bioassays,thenonineolignanamericaninAwasfoundtobeapotentantioxidantintheseassays.64
Varioustreatmentsofnonijuicemayaffectitsantioxidantproperties.Forexample,Yangetal.reportthetotalantioxidantcapacity(TAC)in
freshnonijuicetobeequivalentto127mgascorbicacidper100mLinascavengerassayof1,1diphenyl2picrylhydrazyl(DPPH).48After
twomonthstraditionalfermentation,TACdecreasedby70%.Storageoffreshnonijuiceat24CfortwomonthsdecreasedTACby80%,
whilestorageat18CexhibitednosignificantchangeinTAC.HotairandfreezedriednonipowdersexhibitedreductioninTACby45%and
20%,respectively.Thepasteurizationofnonijuiceseemstohavenoeffectonitschemistryandperformanceinoxygenradicalabsorbance
capacity(ORAC)assays,butenzymetreatmentseemstohaveanegativeeffectonantioxidantcapacity.40
Antitumoreffects:Variousextractsandconstituentsfromallpartsofthenoniplanthavebeentestedfortheireffectonanimalcancer
modelsandcelllines.Inseveralstudies,thenoniextractsuppressedtumorgrowththroughactivationofthehostimmune
system26,27,28,29,30,whichissupportedbyanothernonistudyshowinggeneralimmunostimulationeffects11.Nonihasalsoshowngeneral
cytotoxicityeffects31,whichmaybedosedependent11.However,theseeffectsarenotuniversalacrossallcancerlines.31Noniextracts
haveexhibitedspecificinhibitoryeffectsonRasoncogenefunction32,celltransformationinducedby12Otetradecanoylphorbol13acetate
(TPA)orepidermalgrowthfactor(EGF)33,34,thetumorpromotingeffectoftumornecrosisfactora(TNFa)35,andactivatorprotein1
transactivation36.Whenadministeredbeforetheinductionofacancer,noniextracthasshownpreventativeeffects.23,37,38,39Specifically,
theanthraquinone2methoxy1,3,6trihydroxyanthraquinonemaybeapotentquininereducataseinducerthatisnearly40timesmorepotent
thanthepositivecontrollsulforaphane.2Onasidenote,thepasteurizationofnonijuiceseemstohavenoeffectonitschemistryand
performanceinNFkappaBactivity.40
Antiviraleffects:Onespecificcompoundisolatedfromnoniroots,1methoxy2formyl3hydroxyanthraquinone,suppressedcytopathic
effectofHIVinfectedMT4cellsinvitro,withoutinhibitingcellgrowth.41However,theaqueousanddichloromethaneextractofnonifruits
showedpracticallynoactivityagainstHIV1invitro.42
Gastrointestinaleffects:Puetal.studiedtheeffectsofMorindacitrifoliajuiceongastricemptying,gastrointestinaltransit,andplasmalevel
ofcholecystokinininrats.4Maleratsweregivennonibygavageatlevelsof0.25,1,or4mL/kgonceperdayforoneorsevendays.Therats
inthecontrolgroupweregivenwater,whiletheratsintheexperimentalgroupwerefastedovernightbeforemeasurementofgastrointestinal
motility.Gastrointestinalmotilitywasassessedinrats15minutesafterintragastricinstillationofatestmealcontainingcharcoal(10%)and
Na251CrO4(0.5mcCi/mL)asamarker.Gastricemptyingwasdeterminedbymeasuringtheamountofradiolabeledchromiumcontainedin
thesmallintestineasapercentageoftheinitialamountreceived.Then,gastrointestinaltransitwasevaluatedbycalculatingthegeometric
centerofdistributionoftheradiolabeledmarker.Finally,bloodsampleswerecollectedformeasurementofcholecystokininby
radioimmunoassay.Theadministrationofnoniat0.25mL/kg,butnotat1mL/kgand4mL/kg,foronedaysignificantlyinhibitedgastric
emptying.Incontrast,gastricemptyingwassignificantlyinhibitedbyoraladministrationofnoni(0.25,1,or4mL/kg)forsevendays.
Intraperitonealinjectionoflorglumide(5or10mg/kg),aselectivecholecystokinin1receptorantagonist,effectivelyattenuatedthenoni
inducedinhibitionofgastricemptying.Intestinaltransitandbodyweight,foodintake,waterintake,urinevolume,andfecesweightwerenot
alteredbytheadministrationofnoniacutelyorchronically,buttheadministrationoforalnoni(1mL/kg)forsevendaysincreasedthelevelof
plasmacholecystokinininmalerats.Theseresultssuggestthatoralnoniinhibitsgastricemptyinginmaleratsviaamechanisminvolving
stimulationofcholecystokininsecretionandcholecystokinin1receptoractivation.
Immunesystemeffects:ThethymuswetweightinanimalstreatedwithTahitianNonijuice(TNJ)wasabout1.7timesthatofcontrol
animalsaftersevendaysadministrationof10%TNJindrinkingwater.11ThisincreaseinweightmayindicatethatTNJenhancesimmune
functionbystimulatingthymusgrowth,andthusaffectingantiagingandanticanceractivities.
Metaboliceffects:Nonifruitcontainsanaturalprecursorforxeronine,calledproxeronine,whichishypotheticallyconvertedinthebodyto
thealkaloidxeronine.Ithasbeenhypothesizedthatxeronineisabletomodifythemolecularstructureofproteinsandisacriticalnormal
metaboliccoregulator.43,44

Pharmacodynamics/Kinetics:
ThepharmacokineticsofnoniwasstudiedinfemaleSpragueDawleyratsafteroraladministrationatadoseof1mLnonipureeper100g
bodyweightwithscopoletinasamarker.11Theplasmaconcentrationofscopoletinreachedapeaktwohoursafteroraladministration.The
peakleveldecreasedto50%infourhours.Only12%and2%,respectively,wasleftintheplasmaat12and24hours.Absorptionwasrapid,
with50%peakconcentrationreachedinonly30minutes.Theconcentrationofscopoletininvariousorgansindicatesthatitisabsorbedinto
differenttissuesapproximatelyonehourafteradministration.Thepeakconcentrationindifferenttissuesoccurredafteraboutthreehours,
witharapiddecline.Thescopoletinlevelinbreasttissuewashigherrelativetootherextragastrointestinaltracttissue.Thisisnotadefinite
descriptionofnonipharmacokineticsasnoniisanextractcomposedofnumerouscomponents.Themeasurementofscopoletinasamarker
ofthenonicompoundcannotbeassumedtorepresenttherest,oreventhemajorityofnonicompounds.

References
1. Kamiya,K.,Tanaka,Y.,Endang,H.,Umar,M.,andSatake,T.NewanthraquinoneandiridoidfromthefruitsofMorindacitrifolia.ChemPharm
Bull(Tokyo)200553(12):15971599.16327199
2. Pawlus,A.D.,Su,B.N.,Keller,W.J.,andKinghorn,A.D.Ananthraquinonewithpotentquinonereductaseinducingactivityandother
constituentsofthefruitsofMorindacitrifolia(noni).JNatProd200568(12):17201722.16378361
3. Issell,B.F.,Gotay,C.,Pagano,I.,andFranke,A.QualityoflifemeasuresinaphaseItrialofnoni2005
4. Pu,H.F.,Huang,W.J.,Tseng,W.M.,Wang,S.W.,Liu,Y.W.,Doong,M.L.,andWang,P.S.EffectsofjuicefromMorindacitrifolia(Noni)on
gastricemptyinginmalerats.ChinJPhysiol1231200447(4):169174.15803749
5. DANG,VANHO.[AbasictreatmentforarterialhypertensionwithextractsoftherootsofMorindacitrifilia(CayNhau).].PresseMed73
195462(48):10201021.13194596
6. DANG,VANHO.[TreatmentandpreventionofhypertensionanditscerebralcomplicationsbytotalrootextractsofMorindacitrifolia.].Presse
Med112195563(72):1478.13280670
7. LABARRE,J.,HANS,M.,andHANS,M.J.[Aproposofthehypotensive,diureticandtranquilizingpropertiesofpurifiedextractsofMorinda.].
BullAcadRMedBelg19611:567581.13757907
8. Moorthy,N.K.andReddy,G.S.PreliminaryphytochemicalandpharmacologicalstudyofMorindacitrifoliaL.Antiseptic197097:167171.
9. YOUNGKEN,H.W.,Sr.AstudyoftherootofMorindacitrifoliaLinne.I.JAmPharmAssocAmPharmAssoc(Baltim)195847(3,Part1):162
165.13525210
10. YOUNGKEN,H.W.,Sr.,JENKINS,H.J.,andBUTLER,C.L.StudiesonMorindacitrifoliaL.II.JAmPharmAssocAmPharmAssoc
196049:271273.13855457
11. Wang,M.Y.,West,B.J.,Jensen,C.J.,Nowicki,D.,Su,C.,Palu,A.K.,andAnderson,G.Morindacitrifolia(Noni):aliteraturereviewand
recentadvancesinNoniresearch.ActaPharmacolSin200223(12):11271141.12466051
12. Younos,C.,Rolland,A.,Fleurentin,J.,Lanhers,M.C.,Misslin,R.,andMortier,F.AnalgesicandbehaviouraleffectsofMorindacitrifolia.
PlantaMed199056(5):430434.1981810
13. Raj,R.K.ScreeningofindigenousplantsforanthelminticactionagainsthumanAscarislumbricoides:PartII.IndianJPhysiolPharmacol
197519(1):UNKNOWN.1158424
14. Hornick,C.A.,Myers,A.,SadowskaKrowicka,H.,Anthony,C.T.,andWoltering,E.A.Inhibitionofangiogenicinitiationanddisruptionof
newlyestablishedhumanvascularnetworksbyjuicefromMorindacitrifolia(noni).Angiogenesis20036(2):143149.14739620
15. ATKINSON,N.Antibacterialsubstancesfromfloweringplants.3.AntibacterialactivityofdriedAustralianplantsbyarapiddirectplatetest.
AustJExpBiolMedSci195634(1):1726.13328723
16. Bushnell,O.A.,Fukuda,M.,andMakinodian,T.TheantibacterialpropertiesofsomeplantsfoundinHawaii.PacSci19504:167183.
17. Duncan,S.H.,Flint,H.J.,andStewart,C.S.InhibitoryactivityofgutbacteriaagainstEscherichiacoli0157mediatedbydietaryplant

http://www.sigmaaldrich.com/lifescience/nutritionresearch/learningcenter/plantprofiler/morindacitrifolia.html

2/4

01/03/2015

Noni(Morindacitrifolia)|PlantProfiler|SigmaAldrich
metabolites.FEMSMicrobiolLett1998164:283285.
18. Locher,C.P.,Burch,M.T.,Mower,H.F.,Berestecky,J.,Davis,H.,VanPoel,B.,Lasure,A.,VandenBerghe,D.A.,andVlietinck,A.J.Anti
microbialactivityandanticomplementactivityofextractsobtainedfromselectedHawaiianmedicinalplants.JEthnopharmacol1117
199549(1):2332.8786654
19. Leach,A.J.,Leach,D.N.,andLeach,G.J.AntibacterialactivityofsomemedicinalplantsofPapuaNewGuinea.SciNewGuinea198814:1
7.
20. Saludes,J.P.,Garson,M.J.,Franzblau,S.G.,andAguinaldo,A.M.AntitubercularconstituentsfromthehexanefractionofMorindacitrifolia
Linn.(Rubiaceae).PhytotherRes200216(7):683685.12410555
21. Su,C.,Wang,M.Y.,Nowicki,D.,Jensen,J.,andAnderson,G.SelectiveCOX2inhibitionofMorindacitrifolia(Noni)invitro20017thAnn
Conf
22. Li,R.W.,Myers,S.P.,Leach,D.N.,Lin,G.D.,andLeach,G.Acrossculturalstudy:antiinflammatoryactivityofAustralianandChinese
plants.JEthnopharmacol200385(1):2532.12576199
23. Wang,M.Y.,Su,C.,Nowicki,D.,Jensen,J.,andAnderson,G.Morindacitrifoliaandcancerprevention.JNutrition2001131(11S):3151S.
24. McKoy,M.L.,Thomas,E.A.,andSimon,O.R.Preliminaryinvestigationoftheantiinflammatorypropertiesofanaqueousextractfrom
Morindacitrifolia(noni).ProcWestPharmacolSoc200245:7678.12434536
25. Kamiya,K.,Tanaka,Y.,Endang,H.,Umar,M.,andSatake,T.ChemicalconstituentsofMorindacitrifoliafruitsinhibitcopperinducedlow
densitylipoproteinoxidation.JAgricFoodChem922200452(19):58435848.15366830
26. Hirazumi,A.,Furusawa,E.,Chou,S.C.,andHokama,Y.AnticanceractivityofMorindacitrifolia(noni)onintraperitoneallyimplantedLewis
lungcarcinomainsyngeneicmice.ProcWestPharmacolSoc199437:145146.7984648
27. Hirazumi,A.,Furusawa,E.,Chou,S.C.,andHokama,Y.Immunomodulationcontributestotheanticanceractivityofmorindacitrifolia(noni)
fruitjuice.ProcWestPharmacolSoc199639:79.8895953
28. Hirazumi,A.andFurusawa,E.AnimmunomodulatorypolysacchariderichsubstancefromthefruitjuiceofMorindacitrifolia(noni)with
antitumouractivity.PhytotherRes199913(5):380387.10441776
29. Furusawa,E.,Hirazumi,A.,Story,S.,andJensen,J.AntitumourpotentialofapolysacchariderichsubstancefromthefruitjuiceofMorinda
citrifolia(Noni)onsarcoma180ascitestumourinmice.PhytotherRes200317(10):11581164.14669249
30. Hokama,Y.TheeffectofNonifruitextract(Morindacitrifolia,Indianmulberry)onthymocytesofBALB/cmouse.FASEBJ19937:A866.
31. Arpornsuwan,T.andPunjanon,T.TumorcellselectiveantiproliferativeeffectoftheextractfromMorindacitrifoliafruits.PhytotherRes
200620(6):515517.16619339
32. Hiramatsu,T.,Imoto,M.,Koyano,T.,andUmezawa,K.Inductionofnormalphenotypesinrastransformedcellsbydamnacanthalfrom
Morindacitrifolia.CancerLett930199373(23):161166.7693328
33. Liu,G.,Bode,A.,Ma,W.Y.,Sang,S.,Ho,C.T.,andDong,Z.TwonovelglycosidesfromthefruitsofMorindacitrifolia(noni)inhibitAP1
transactivationandcelltransformationinthemouseepidermalJB6cellline.CancerRes81200161(15):57495756.11479211
34. Sang,S.,He,K.,Liu,G.,Zhu,N.,Cheng,X.,Wang,M.,Zheng,Q.,Dong,Z.,Ghai,G.,Rosen,R.T.,andHo,C.T.Anewunusualiridoidwith
inhibitionofactivatorprotein1(AP1)fromtheleavesofMorindacitrifoliaL.OrgLett5320013(9):13071309.11348221
35. Asahina,A.Y.,Ebesu,J.S.M.,Ichinotsubo,D.,Tongson,J.,andHokama,Y.Effectofokadaicacid(OA)andNonifruitextractioninthe
synthesisoftumournecrosisfactora(TNFa)byperipheralbloodmononuclear(PBN)cellsinvitro1994197205.
36. Sang,S.,Liu,G.,He,K.,Zhu,N.,Dong,Z.,Zheng,Q.,Rosen,R.T.,andHo,C.T.Newunusualiridoidsfromtheleavesofnoni(Morinda
citrifoliaL.)showinhibitoryeffectonultravioletBinducedtranscriptionalactivatorprotein1(AP1)activity.BioorgMedChem612
200311(12):24992502.12757717
37. Wang,M.Y.,Anderson,G.,andNowicki,D.PreventiveeffectofMorindacitrifolia(Noni)attheinitiationstageofmammarybreastcancer
inducedby7,12dimethylbenz(a)anthracen(DMBA)infemaleSpragueDawleyrats2002
38. Wang,M.Y.,Nowicki,D.,andAnderson,G.ProtectiveeffectofMorindacitrifoliaonhepaticinjuryinducedbyalivercarcinogen
200243:477.
39. Hiwasa,T.,Arase,Y.,Chen,Z.,Kita,K.,Umezawa,K.,Ito,H.,andSuzuki,N.Stimulationofultravioletinducedapoptosisofhumanfibroblast
UVr1cellsbytyrosinekinaseinhibitors.FEBSLett2121999444(23):173176.10050753
40. Banbury,L.andBrushett,D.ReportonInvestigationofNoniJuice.Unpublishedmanuscript2004
41. Umezawa,K.Isolationof1methoxy2foremyl3hydroxyanthraquinonefromM.citrifoliaandneoplasminhibitorscontainingthesame.Japan
KokaiTokyoKohoJP0687,736(9487,736)1992Appl:9226431107.
42. Locher,C.P.,Wtivrouw,M.,Bethunnede,M.P.,Burch,M.T.,Mover,H.F.,Davis,H.,Lasure,A.,Pauwels,R.,Clercqde,E.,andVlietnick,A.
J.AntiviralactivityofHaiwaiianmedicinalplantsagainsthumanimmunodeficiencyVirusType1(HIV1).Phytomedicine19962(3):259264.
43. Heinicke,R.ThepharmacologicallyactiveingredientofNoni1985
44. Heinicke,R.TheXeroninesystem:anewcellularmechanismthatexplainsthehealthpromotingactionofNONIandBromelain2001
45. Wang,M.,Kikuzaki,H.,Jin,Y.,Nakatani,N.,Zhu,N.,Csiszar,K.,Boyd,C.,Rosen,R.T.,Ghai,G.,andHo,C.T.Novelglycosidesfromnoni
(Morindacitrifolia).JNatProd200063(8):11821183.10978225
46. Wang,M.Y.andSu,C.CancerpreventiveeffectofMorindacitrifolia(Noni).AnnNYAcadSci2001952:161168.11795436
47. Wang,M.Y.,Su,C.,Nowicki,D.,Jensen,J.,andAnderson,G.ProtectiveeffectofMorindacitrifoliaincarbontetrachlorideinducedliverinjury
model:Alightandelectronmicroscopicstudy20017thAnnConf
48. Yang,J.,Paulino,R.J.,andJankeStedronsky,S.TotalantioxidantcapacityofNoniProductsasAffectedbyProcessingandStorage2004
49. Levand,O.andLarson,H.O.SomechemicalconstituentsofMorindacitrifolia.PlantaMed197936(2):186187.461575
50. Farine,J.P.,Legal,L.,Moreteau,B.,andLeQuere,J.L.VolatilecomponentsofripefruitsofMorindacitrifoliaandtheireffectsonDrosophila.
Phytochemistry199641:433438.
51. Peerzada,N.,Renaud,S.,andRyan,P.VitaminCandelementalcompositionofsomebushfruits.JPlantNutrition199013:787793.
52. Daulatabad,C.D.,Mulla,G.M.,andMirajikar,A.M.RiconoleicacidinMorindacitrifoliaseedoil.OilTechAssIndia198921:2627.
53. Balakrishna,S.,Seshadri,TR.,andVenkataramani,B.Specialchemicalcomponentofcommercialwoodsandrelatedplantmaterials:Part
XHeartwoodofMorindacitrifoliaLinn.JSciIndRes196120B:331333.
54. Legal,L.,David,J.R.,andJallon,J.M.MolecularbasisofMorindacitrifolia(L.):toxicityonDrosophila.JChemEcolog199420:19311943.
55. Singh,J.andTiwari,R.D.FlavoneglycosidesfromtheflowersofMorindacitrifolia.JIndianChemSoc197653:424.
56. Simonsen,J.L.NoteontheconstituentsofMorindacitrifolia.JChemSoc1920117:561564.
57. Siddiqui,B.S.,Ismail,F.A.,Gulzar,T.,andBegum,S.Isolationandstructuredeterminationofabenzofuranandabisnorisoprenoidfrom
AspergillusnigergrownonthewatersolublefractionofMorindacitrifoliaLinn.leaves.NatProdRes200317(5):355360.14526916
58. ElNaggar,L.J.andBeal,J.L.Iridoids.AReview.JNatProd198043:649707.
59. Shotipruk,A.,Kiatsongserm,J.,Pavasant,P.,Goto,M.,andSasaki,M.Pressurizedhotwaterextractionofanthraquinonesfromtherootsof
Morindacitrifolia.BiotechnolProg200420(6):18721875.15575725
60. Ancolio,C.,Azas,N.,Mahiou,V.,Ollivier,E.,DiGiorgio,C.,Keita,A.,TimonDavid,P.,andBalansard,G.Antimalarialactivityofextractsand
alkaloidsisolatedfromsixplantsusedintraditionalmedicineinMaliandSaoTome.PhytotherRes200216(7):646649.12410545
61. Wang,M.,Kikuzaki,H.,Csiszar,K.,Boyd,C.D.,Maunakea,A.,Fong,S.F.,Ghai,G.,Rosen,R.T.,Nakatani,N.,andHo,C.T.Novel
trisaccharidefattyacidesteridentifiedfromthefruitsofMorindacitrifolia(Noni).JAgricFoodChem199947(12):48804882.10606546
62. Sang,S.,Cheng,X.,Zhu,N.,Wang,M.,Jhoo,J.W.,Stark,R.E.,Badmaev,V.,Ghai,G.,Rosen,R.T.,andHo,C.T.Iridoidglycosidesfromthe
leavesofMorindacitrifolia.JNatProd200164(6):799800.11421748
63. Sang,S.,Cheng,X.,Zhu,N.,Stark,R.E.,Badmaev,V.,Ghai,G.,Rosen,R.T.,andHo,C.T.Flavonolglycosidesandnoveliridoidglycoside
fromtheleavesofMorindacitrifolia.JAgricFoodChem200149(9):44784481.11559157
64. Su,B.N.,Pawlus,A.D.,Jung,H.A.,Keller,W.J.,McLaughlin,J.L.,andKinghorn,A.D.ChemicalconstituentsofthefruitsofMorinda
citrifolia(Noni)andtheirantioxidantactivity.JNatProd200568(4):592595.15844957
65. Punjanon,T.andNandhasri,P.AnalgesiceffectofthealcoholicextractfromthefruitsofMorindacitrifolia20054:678.
66. Salleh,M.N.,Runnie,I.,Roach,P.D.,Mohamed,S.,andAbeywardena,M.Y.Inhibitionoflowdensitylipoproteinoxidationandup
regulationoflowdensitylipoproteinreceptorinHepG2cellsbytropicalplantextracts.JAgricFoodChem619200250(13):36933697.
12059144
67. Stevenson,L.andBanbury,L.Nonijuiceandcholesterolsynthesisinhibition2004

http://www.sigmaaldrich.com/lifescience/nutritionresearch/learningcenter/plantprofiler/morindacitrifolia.html

3/4

01/03/2015

Noni(Morindacitrifolia)|PlantProfiler|SigmaAldrich
LicensedbyNaturalStandardCopyright2010byNaturalStandardCorporation.AllRightsReserved.
backtoPlantProfiler
backtotop

SERVICE&SUPPORT

CORPORATE

CUSTOMERSUPPORT
TECHNICALSERVICE
WEBHELPDESK
MSDS
COFA

INVESTORRELATIONS
BUSINESSDEVELOPMENT
WORLDWIDEOFFICES
ABOUTUS
SITEMAP
CAREERS
EVENTS
PROGRAMS
REACHREGULATIONS
CONTACTUS
LITERATUREPORTAL
TOOLBOX

ORDERING
CUSTOMPRODUCTS
ECOMMERCESOLUTIONS
ORDERCENTER
PRODUCTS
TERMS&CONDITIONSOFSALE

Copyright 2015 SigmaAldrich Co. LLC. All Rights Reserved.Reproductionofanymaterialsfromthesiteisstrictly


forbiddenwithoutpermission.SigmaAldrichbrandproductsaresoldexclusivelythroughSigmaAldrichCo.LLC.SiteUseTerms|
Privacy

http://www.sigmaaldrich.com/lifescience/nutritionresearch/learningcenter/plantprofiler/morindacitrifolia.html

4/4