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Bepridil
Systematic (IUPAC) name
()-(beta)-[(2-Methylpropoxy)methyl]-N-phenyl- N (phenyl- methyl)-1-pyrrolidineethanamine

Identifiers
CAS number
ATC code
PubChem
DrugBank
Chemical data
Formula
Mol. mass
Pharmacokinetic data
Bioavailability
Protein binding
Metabolism

64706-54-3
C08EA02
2351
APRD00727
C24H34N2O
366.23 g/mol

Well absorbed
99%
Hepatic, CYP3A4mediated
Half life
42 hours
Excretion
Renal
Therapeutic considerations
Pregnancy cat.
C(US)
Legal status
Routes
Oral

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Amlodipine
Systematic (IUPAC) name
3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2chlorophenyl)-1,4-dihydro-6-methyl-3,5pyridinedicarboxylate

Identifiers
CAS number
88150-42-9
ATC code
C08CA01
PubChem
2162
DrugBank
APRD00520
Chemical data
Formula
C20H25ClN2O5
Mol. mass
408.879 g/mol
SMILES
eMolecules & PubChem
Pharmacokinetic data
Bioavailability 64 to 90%
Metabolism
Hepatic
Half life
30 to 50 hours
Excretion
Renal
Therapeutic considerations
Pregnancy cat.
C(AU) C(US)
Legal status
POM(UK) -only(US)
Routes
Oral (tablets)

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Benidipine
Systematic (IUPAC) name
O5-methyl O3-[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5dicarboxylate

Identifiers
CAS number
?
ATC code
C08CA15
PubChem
60065
Chemical data
Formula
C28H31N3O6
Mol. mass
?
Pharmacokinetic data
Bioavailability
?
Metabolism
?
Half life
?
Excretion
?
Therapeutic considerations
Pregnancy cat.
?
Legal status
Routes
Oral

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Felodipine
Systematic (IUPAC) name
ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro
-2,6-dimethyl-3,5- pyridinedicarboxylate

Identifiers
CAS number
72509-76-3
ATC code
C08CA02
PubChem
3333
DrugBank
APRD00374
Chemical data
Formula
C18H19Cl2NO4
Mol. mass
383.069 g/mol
Pharmacokinetic data
Bioavailability >95% [1]
Metabolism
Hepatic
Half life
??
Excretion
Renal
Therapeutic considerations
Pregnancy cat.
C(US)
Legal status
Prescription only
Routes
Oral

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Isradipine
Systematic (IUPAC) name
methyl propan-2-yl 2,6-dimethyl-4- (8-oxa-7,9diazabicyclo[4.3.0] nona- 2,4,6,9- tetraen- 5-yl)- 1,4dihydropyridine- 3,5-dicarboxylate

Identifiers
CAS number
75695-93-1
ATC code
C08CA03
PubChem
3784
DrugBank
APRD00298
Chemical data
Formula
C19H21N3O5
Mol. mass
371.387 g/mol
Pharmacokinetic data
Bioavailability
?
Protein binding
95%
Metabolism
?
Half life
8 hours
Excretion
?
Therapeutic considerations
Pregnancy cat.
?
Legal status
Routes
?

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Lacidipine
Systematic (IUPAC) name
diethyl 2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5dicarboxylate

Identifiers
CAS number
?
ATC code
C08CA09
PubChem
5311217
Chemical data
Formula
C26H33NO6
Mol. mass
455.543 g/mol
Pharmacokinetic data
Bioavailability
?
Metabolism
?
Half life
?
Excretion
?
Therapeutic considerations
Pregnancy cat.
?
Legal status
Routes
?

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Lercanidipine
Systematic (IUPAC) name
methyl[2-(3,3-diphenylpropyl-methyl-amino)- 1,1-dimethylethyl] 2,6-dimethyl- 4-(3-nitrophenyl)- 1,4-dihydropyridine3, 5-dicarboxylate

Identifiers
CAS number
100427-26-7
ATC code
C08CA13
PubChem
65866
DrugBank
APRD00193
Chemical data
Formula
C36H41N3O6
Mol. mass
611.727 g/mol
Pharmacokinetic data
Bioavailability
?
Metabolism
?
Half life
?
Excretion
?
Therapeutic considerations
Pregnancy cat.
?
Legal status
Routes
?

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Nicardipine
Systematic (IUPAC) name
methyl2-(benzyl-methyl-amino)ethyl2,6-dimethyl-4- (3nitrophenyl)-1,4-dihydropyridine- 3,5-dicarboxylate

Identifiers
CAS number
55985-32-5
ATC code
C08CA04
PubChem
4474
DrugBank
APRD00088
Chemical data
Formula
C26H29N3O6
Mol. mass
479.525 g/mol
Physical data
Melt. point
6 C (43 F)
Pharmacokinetic data
Bioavailability
?
Protein binding
>95%
Metabolism
?
Half life
8.6 hours
Excretion
?
Therapeutic considerations
Pregnancy cat.
?
Legal status
Routes
?

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Nifedipine
Systematic (IUPAC) name
dimethyl2,6-dimethyl-4-(2-nitrophenyl)- 1,4dihydropyridine-3,5-dicarboxylate

Identifiers
CAS number
21829-25-4
ATC code
C08CA05
PubChem
4485
DrugBank
APRD00590
Chemical data
Formula
C17H18N2O6
Mol. mass
346.335 g/mol
Physical data
Melt. point
173 C (343 F)
Pharmacokinetic data
Bioavailability
45-56%
Protein binding
92-98%
Metabolism
Gastrointestinal,
Hepatic
Half life
2 hours
Excretion
Renal: >50%, Biliary:
5-15%
Therapeutic considerations
Pregnancy cat.
C: (USA)
Legal status
Routes
Oral

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Nilvadipine
Systematic (IUPAC) name
O3-Methyl O5-propan-2-yl 2-cyano-6-methyl-4-(3nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Identifiers
CAS number
?
ATC code
C08CA10
PubChem
4494
Chemical data
Formula
C19H19N3O6
Mol. mass
385.370 g/mol
Pharmacokinetic data
Bioavailability
?
Metabolism
?
Half life
?
Excretion
?
Therapeutic considerations
Pregnancy cat.
?
Legal status
Routes
?

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Nimodipine
Systematic (IUPAC) name
2-methoxyethyl1-methylethyl2,6-dimethyl-4-(3-nitrophenyl)
-1,4-dihydropyridine-3,5- dicarboxylate

Identifiers
CAS number
66085-59-4
ATC code
C08CA06
PubChem
4497
DrugBank
APRD00612
Chemical data
Formula
C21H26N2O7
Mol. mass
418.44 g/mol
Physical data
Melt. point
7 C (45 F)
Pharmacokinetic data
Bioavailability
100%
(Intravenous) 13%
(Oral)
Protein binding
95%
Metabolism
Hepatic
Half life
8-9 hours
Excretion
?
Therapeutic considerations
Pregnancy cat.
C: (USA)
Legal status
Routes
Intravenous, Oral

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Nisoldipine
Systematic (IUPAC) name
methyl2- methylpropyl2,6-dimethyl-4-(2-nitrophenyl)- 1,4dihydropyridine-3,5-dicarboxylate

Identifiers
CAS number
63675-72-9
ATC code
C08CA07
PubChem
4499
DrugBank
APRD00635
Chemical data
Formula
C20H24N2O6
Mol. mass
388.414 g/mol
Pharmacokinetic data
Bioavailability
?
Protein binding
99%
Metabolism
?
Half life
7-12 hours
Excretion
?
Therapeutic considerations
Pregnancy cat.
C(US)
Legal status
-only(US)
Routes
Oral

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Nitrendipine
Systematic (IUPAC) name
ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4dihydropyridine-3,5-dicarboxylate

Identifiers
CAS number
39562-70-4
ATC code
C08CA08
PubChem
4507
Chemical data
Formula
C18H20N2O6
Mol. mass
360.361 g/mol
Pharmacokinetic data
Bioavailability
?
Metabolism
?
Half life
?
Excretion
?
Therapeutic considerations
Pregnancy cat.
?
Legal status
Routes
?

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Verapamil
Systematic (IUPAC) name
2-(3,4-dimethoxyphenyl)-5-[2-(3,4dimethoxyphenyl)ethyl-methyl-amino]
-2-(1-methylethyl)pentanenitrile

Identifiers
CAS number
52-53-9
ATC code
C08DA01
PubChem
2520
DrugBank
APRD00335
Chemical data
Formula
C27H38N2O4
Mol. mass
454.602 g/mol
SMILES
eMolecules & PubChem
Pharmacokinetic data
Bioavailability
35.1%
Metabolism
Hepatic
Half life
2.8-7.4 hours
Excretion
Renal: 11%
Therapeutic considerations
Pregnancy cat.
C(US)
Legal status
Prescription only
Routes
Oral, Intravenous

Diltiazem is a member of the group of

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Diltiazem
Systematic (IUPAC) name
[2-(2-dimethylaminoethyl)-5-(4-methoxyphenyl)
-3-oxo-6-thia-2-azabicyclo[5.4.0]undeca-7,9,
11-trien-4-yl]ethanoate

Identifiers
CAS number 42399-41-7
ATC code
C08DB01
PubChem
39186
DrugBank
APRD00473
Chemical data
Formula
C22H26N2O4S
Mol. mass
414.519 g/mol
Pharmacokinetic data
Bioavailability 40%
Metabolism Hepatic
Half life
3-4.5 hours
Excretion
Renal
Biliary
Lactic (in lactiferous
females)
Therapeutic considerations
Pregnancy cat.
D: (USA)
Legal status
Routes
Oral