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Table of Contents
NHMRCs View on Homoeopathy: Do we need to pay attention? ................................................................ 1
Generic Protocol for Clinicians ................................................................................................................................ 1
Generic Protocol for Clinicians: Hypothyroidism ............................................................................................. 2
Hypothyroidism: Enhancing Clinical Practice & Research ............................................................................ 2
Studies to be Read ........................................................................................................................................................ 3
Fundamental Research ....................................................................................................................................................................... 3
Effects of homeopathic Anax imperator on behavioural and pain models in mice...................................... 3
Effect of homeopathic Lycopodium clavatum on memory functions and cerebral blood flow in
memory-impaired rats................................................................................................................................................................. 3
Hepatoprotective effect of Lycopodium clavatum 30CH on experimental model of paracetamolinduced liver damage in rats .................................................................................................................................................... 4
DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by Ruta graveolens in
human colon cancer cells............................................................................................................................................................ 5
Trypanosoma cruzi: Biotherapy made from trypomastigote modulates the inflammatory response
.................................................................................................................................................................................................................. 5
Reconstituted mother tinctures of Gelsemium sempervirens L. improve memory and cognitive
impairment in mice scopolamine-induced dementia model. .................................................................................. 6
Transfer of the effect of potentized mercuric chloride on -amylase from one test tube to another
through capillary water............................................................................................................................................................... 7
Clinical Research ..................................................................................................................................................................................... 7
Homeopathic treatment of multimorbid patients: a prospective outcome study with polarity
analysis................................................................................................................................................................................................. 7
A Double-Blind Randomized Placebo-Controlled Feasibility Study Evaluating Individualized
Homeopathy in Managing Pain of Knee Osteoarthritis............................................................................................... 8
Documentation of Prescriptions and Clinical Outcomes in a Homeopathic Hospital Setting in West
Bengal, India ...................................................................................................................................................................................... 8
Usefulness of the homeopathic repertory in the management of chronic suppurative otitis media . 9
Usefulness of homeopathy in essential hypertension: an exploratory interventional trial .................... 9
Individualized Homeopathic Treatment and Fluoxetine for Moderate to Severe Depression in Periand Postmenopausal Women (HOMDEP-MENOP Study): A Randomized, Double-Dummy, DoubleBlind, Placebo-Controlled Trial. ........................................................................................................................................... 10
Effects of homeopathic mother tinctures on breath alcohol testing................................................................. 10
Veterinary ................................................................................................................................................................................................. 11
Veterinary homeopathy: meta-analysis of randomised placebo-controlled trials.................................... 11
Effect of a homeopathic complex on reproductive performance in a commercial pig farm ................ 11
Review ......................................................................................................................................................................................................... 12
Homeopathic Oscillococcinum for preventing and treating influenza and influenza-like illness. 12
Upcoming Events ........................................................................................................................................................14
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Andrea Szekely
Priya Kamath
Saurav Arora
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Studies to be Read
Abstracts of peer reviewed studies published during January March 2015
Fundamental Research
Homeopathy 2015;104(1):15-23
Effects of homeopathic Anax imperator
on behavioural and pain models in mice
Oguz Mutlu, Guner Ulak, Sibel Kokturk, Ipek
Komsuoglu Celikyurt, Furuzan Akar, Faruk
Erden
Background: Homeopathy is a medical
theory and practice that asserts that disease
can be cured by remedies that produce
symptoms in a healthy person similar to
those suffered by a patient with a malady.
Methods: The aim of this study was to
investigate effects of homeopathic Anax
imperator (dragonfly) (Anax-i 30c and
Anax-i 200c) in the forced swim test (FST),
elevated plus-maze (EPM) test, hot plate
(HP) test and open field test and examined
NPY1 receptor expression, in naive mice.
Results: In the FST, treatment with Anax-i
30c or Anax-i 200c significantly diminished
immobility time while in EPM test, Anax-i
200c increased the percentage of time spent
in open arms as well as the percentage of
open arm/total arms. In the HP test, Anax-i
30c or Anax-i 200c decreased the total time
mice spent licking their hind paws while in
open field test, treatment with Anax-i 200c
increased the total distance and speed mice
traveled compared to the control group.
Three weeks of daily injections with Anax-i
30c or Anax-i 200c caused significant
weight loss in mice. Anax-i 30c or Anax-i
200c treatment significantly decreased
NPY1 receptor expression, and Anax-i 30c
also decreased NPY2 receptor expression.
Conclusion: These results suggest that the
homeopathic Anax-i exerts antidepressant,
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Homeopathy 2015;104(1):36-47
DNA fragmentation and cell cycle arrest:
a hallmark of apoptosis induced by Ruta
graveolens in human colon cancer cells
Homeopathy 2015;104(1)48-56
Trypanosoma cruzi: Biotherapy made
from trypomastigote modulates the
inflammatory response
Ethnopharmacological
relevance:
Gelsemium sempervirens (L.) J.St.-Hil is a
herb used for the treatment of various
neuroses in both homeopathic and
Ayurvedic systems. The present study
examines whether Gelsemium reconstituted
tincture can protect against scopolamine
induced cognitive discrepancies in amnesic
mouse model. In order to investigate the
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Keywords:
Water,
alpha-amylase,
Mercurius corrosivus 30 cH, starch, maltose,
high dilutions
Clinical Research
Homeopathy 2015;104(1):57-65
Homeopathic treatment of multimorbid
patients: a prospective outcome study
with polarity analysis
Heiner Frei
Background: The treatment of multimorbid
patients who have a combination of three or
more concurrent complaints is one of the
core competencies of homeopathy. In this
Read online at www.audesapere.in/ejournal
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ClinicalTrials.gov
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Veterinary
Homeopathy 2015;104(1):3-8
Veterinary homeopathy: meta-analysis
of randomised placebo-controlled trials
Robert T. Mathie, Jrgen Clausen
Background: Meta-analysis of randomised
controlled trials (RCTs) of veterinary
homeopathy has not previously been
undertaken. For all medical conditions and
species collectively, we tested the
hypothesis
that
the
outcome
of
homeopathic
intervention
(treatment
and/or prophylaxis, individualised and/or
non-individualised) is distinguishable from
corresponding intervention using placebos.
Methods: All facets of the review, including
literature search strategy, study eligibility,
data extraction and assessment of risk of
bias, were described in an earlier paper. A
trial was judged to comprise reliable
evidence if its risk of bias was low or was
unclear in specific domains of assessment.
Effect size was reported as odds ratio (OR).
A trial was judged free of vested interest if it
was not funded by a homeopathic
pharmacy. Meta-analysis was conducted
using the random-effects model, with
hypothesis-driven sensitivity analysis based
on risk of bias.
Results: Nine of 15 trials with extractable
data displayed high risk of bias; low or
Read online at www.audesapere.in/ejournal
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Review
Cochrane Database Syst Rev. 2015 Jan
28;1:CD001957
Homeopathic
Oscillococcinum
for
preventing and treating influenza and
influenza-like illness.
Mathie RT, Frye J, Fisher P.
Background: Influenza is a highly
infectious viral disease that is particularly
common
in
the
winter
months.
Oscillococcinum
is
a
patented
homeopathic medicine that is made from a
1% solution of wild duck heart and liver
extract, which is then serially diluted 200
times with water and alcohol.
Objectives:
To
determine
whether
homeopathic Oscillococcinum is more
effective than placebo in the prevention
and/or treatment of influenza and
influenza-like illness in adults or children.
Search methods: We searched CENTRAL
(2014, Issue 8), MEDLINE (1966 to August
week 4, 2014), MEDLINE In-Process & Other
Non-Indexed Citations (4 September 2014),
AMED (2006 to September 2014), Web of
Science (1985 to September 2014), LILACS
(1985 to September 2014) and EMBASE
(1980 to September 2014). We contacted
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