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This document provides instructions for synthesizing the psychoactive compound mescaline through a multi-step chemical process, starting with readily available chemical precursors. The synthesis involves reacting 3,4,5-trimethoxybenzaldehyde to form a beta-nitrostyrene intermediate, which is then catalytically hydrogenated using palladium on carbon to yield the final mescaline hydrochloride product. The process aims to provide a pure and high-yielding route to mescaline in a more cost effective manner than extracting it from cacti. With the right equipment and sources for materials, over 500 grams of mescaline hydrochloride can allegedly be produced for less than $1500.
This document provides instructions for synthesizing the psychoactive compound mescaline through a multi-step chemical process, starting with readily available chemical precursors. The synthesis involves reacting 3,4,5-trimethoxybenzaldehyde to form a beta-nitrostyrene intermediate, which is then catalytically hydrogenated using palladium on carbon to yield the final mescaline hydrochloride product. The process aims to provide a pure and high-yielding route to mescaline in a more cost effective manner than extracting it from cacti. With the right equipment and sources for materials, over 500 grams of mescaline hydrochloride can allegedly be produced for less than $1500.
This document provides instructions for synthesizing the psychoactive compound mescaline through a multi-step chemical process, starting with readily available chemical precursors. The synthesis involves reacting 3,4,5-trimethoxybenzaldehyde to form a beta-nitrostyrene intermediate, which is then catalytically hydrogenated using palladium on carbon to yield the final mescaline hydrochloride product. The process aims to provide a pure and high-yielding route to mescaline in a more cost effective manner than extracting it from cacti. With the right equipment and sources for materials, over 500 grams of mescaline hydrochloride can allegedly be produced for less than $1500.
Hate to say it but synthesis is much easier and cost
-effective means for obtaining LARGE yeilds of PURE mescaline HCl. In fact, if you want PURE mesc you have to synthesize, as mentioned earlier when extracting from cacti you do, in fact get more than just mesc. If you find a source for 3,4,5-trimethoxybenzaldehyde then theres a 2-step, very safe, reaction to the corresponding beta-nitrostyrene. Then you have to set up and know how to operate a hydrogenation apparatus that c an withstand 80psi and hydrogenat over Pd/C. If any meth cook can do this I thin k some of the fartsmell.....er smart fellers on here can figure it out. It goes like so; 1. 1000g of 3,4,5TMB is mixed with 280ml Nitromethane and 2100ml EtOH in one co ntainer 2. In another container 420g KOH is mixed with 420ml d-H20 and 840ml MeOH 3. These are mixed together in an Ice bath to keep the temperature down and, upo n full addition, is removed from the ice bath and left to sit at room temp for 3 0min 4. In another 5 gallon glass carboy, make 3gallons of 10%HCl. 5. After the full half-hour of reacting, the reaction mixture is poured into the carboy and submerged in an Ice bath. 6. A yellow precipitate will settle/crystallize out and after it all settles the liquids can be siphoned off throug a funnel and filter to catch and nytrostyren e that may be sucked through. 7. Dissolve all yellow precipitates in boiling MeOH, Filter and cool to form yel low crystal, vaccuum filter off, recrystallize again if needed or desired and st ore in an air tight "blacked-out" jar for future use. This yeilds around 800-900g 3,4,5-Trimethoxy-beta-nitrostyrene. To reduce to 345TMPEA via catalytic hydrogenation, I will quote erowid; Hydrogenation 15g Pd/C 5% 175g 3,4,5TMBnitrostyrene 2.5L Anhydrous EtOH 100ml 31.45% HCl Procedure Add reagents to the keg, begin vigorous stirring Remove atmosphere and pressurize to 75psi with H2 React for 8-10 hours or until H2 uptake has completely ceased Evacuate H2 outside, vacuum out interior of vessel, allow H2 to clear, THEN open the vessel Vacuum filter off Pd/C Re-filter through celite for maximum Pd/C recovery/removal Distill the mixture down until the Ethanol fraction begins to cease Cool and take up what is left in 2L 3N HCl Your remainder may look somewhat black/brown here, but don't worry, this will all be cleared up. If the hydrogenation did not go to completion some unre acted nitrostyrene will remain, this should be filtered from the solution. Wash with 2x125ml DCM Basify to pH>11 dropwise and with stirring with saturated NaOH solution
Extract 3x125ml DCM
Dry over NaSO4 (250g) for 15 minutes Filter off NaSO4 and bubble DCM with HCl(g) anhydrous. After crystalization ceases it can be advantageous to filter and redry the DCM with another 100g NaSO 4, then bubble some more. Collect HCl salt crystals by filtration Final mass yield = 168.74g Mescaline HCl Scale up if you can find a big enough reaction pressure vessel or do it in batch es. As you can see, though, if you can find the right sources this is a much less ex pensive way to get around 5-600g pure mescaline HCl than buying 60+ kilos of dry cactus chips. I actually added up the cost of doing all of this once not too lo ng ago and its less that $1500 including the 345TMB and the Pd/C, which will be the only thing that's actually hard to get a hold of, everything else is availab le all over, but you can find anything in China
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