Packaging for Cream

KAUSAR AHMAD
KULLIYYAH OF PHARMACY
http://staff.iium.edu.my/akausar

PHM4153 Dosage Design 2 2011/12

Contents
2

Packaging materials

Types of packaging

Packaging
requirements

PHM4153 Dosage Design 2 2011/12

Filling

Packaging equipment

Introduction
3

Container
Closure
Correct packaging

Carton
Labeling

PHM4153 Dosage Design 2 2011/12

Packaging Suitability
4

Ability to contain without loss by spillage or

permeation
Protection against environmental hazards
Suit for the function of the product
Free from interaction between the product and
container
Cost
PHM4153 Dosage Design 2 2011/12

Primary Packaging
5

Dosage form

Packaging

Solid

Bottles, Blisters, Sachets

Jars

Liquids

Bottles (glass & plastic)

Drops, Nasal Sprays
Metered dose pumps, Drinkable ampoules

Semi-solid

Tubes (metal, plastic, laminate)

Cans/jars, Applicators
Sticks, Al-cold blister (suppositories)
Suppository blister strips

Sterile

Vials (glass & plastic)

Ampoules, Pre-filled syringes
Ophthalmic tubes (creams), Ophthalmic drops

PHM4153 Dosage Design 2 2011/12

Unit dose packaging

6

plastic tubes
caps that snap off, twist off

and pierce to open.

liquid, ointment.
1 to 5 ml sizes
can have reclosable or non-

reclosable caps.

PHM4153 Dosage Design 2 2011/12

Containers for creams

7

Wide-mouthed squat jars

HTAA?
Collapsible metal
problem?
Flexible plastic tubes
Reduce contamination, narrow orifice
LIMIT: suck-back- may result in microbial contamination,
oxidation,hydrolysis or dehydration
Aluminum tubes

PHM4153 Dosage Design 2 2011/12

Packaging Materials
8

Fabricated from:
Metals
Plastics, rubber
Glass
Any combination from the above
PHM4153 Dosage Design 2 2011/12

Packaging Materials Inspection

9

PHM4153 Dosage Design 2 2011/12

Metals
10

PHM4153 Dosage Design 2 2011/12

A study on internal surfaces of Al tube

11

PHM4153 Dosage Design 2 2011/12

Problems with Al tube

12

PHM4153 Dosage Design 2 2011/12

Polymers - plastics
13

PHM4153 Dosage Design 2 2011/12

Additives in Polymers
14

Add other substances to improve stability, processing behaviour,

or in-use performance.

E.g. PVC

need stabilizers, softeners?

Vulnerable to oxidation

Add antioxidants

These chemicals should not interact with product

PHM4153 Dosage Design 2 2011/12

Ideal Closures
15

Seal the container to prevent loss of product and

ingress of gases or other substances

Withstand sterilization process
Prevent contamination by micro-organism
Non-reactive
Easily remove and replace the closure and reseal (best

reseal with glass fusion)

Material?

PHM4153 Dosage Design 2 2011/12

Basic types of closure

16

PHM4153 Dosage Design 2 2011/12

Filling of Cream
17

PHM4153 Dosage Design 2 2011/12

Packaging equipment - liquid filler

18

Capacities
range from 15ml up to 1 gallon
with neck finishes
of 28mm and larger

PHM4153 Dosage Design 2 2011/12

SECONDARY PACKAGING
19

PHM4153 Dosage Design 2 2011/12

Packaging and Labeling requirements

20

PHM4153 Dosage Design 2 2011/12

AIR CONTROL SYSTEM

21

PHM4153 Dosage Design 2 2011/12

COMPRESSED AIR SYSTEM

22

oil free
hydrocarbon free
dessicant system (-40c dew point)

to prevent air condensation inside packaging that can

affect the quality of products when temperatures vary

PHM4153 Dosage Design 2 2011/12

ELECTRONIC INSPECTION SYSTEM

(WITH CAMERA)
23

PHM4153 Dosage Design 2 2011/12

References
24

http://www.pharmaceuticalonline.com/
http://www.ropack.com/cadre.html
http://www.botlab.com/production.asp
Pizzolitto, E. L., Pizzolitto, A. C. & Pozetti, G. L. (2001). Braz. J.
Microbio. 32:4

PHM4153 Dosage Design 2 2011/12