STEP 1 REVIEW COURSE Part 1, Set 34

1. A 40-year-old man is beginning to have symptoms of a resting tremor, postural instability, and masklike (expressionless) facies. Name the antiviral drug and its mechanism of action that could be used
against this disease. (FA13 p455) (FA14 p496) (SU14 p48) (GG p614)

2. What are the symptoms of decompression sickness? (Phys p538)

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STEP 1 REVIEW COURSE Part 1, Set 34

3. A 55-year-old alcoholic is admitted to the hospital for upper GI bleed. A ruptured esophageal varicose
is found to be the cause. What is the preferred medical treatment for this condition? (FA13 p341)
(FA14 p371) (SU14 p121)

4. A 28-year-old man is being treated with combination of bleomycin, etoposide and cisplatin for
metastatic non-seminoma testicular cancer. The patient develops SOB during the course of treatment.
Pulmonary function testing indicates that the patient has a restrictive lung disease. Which of the
chemotherapy agents is responsible for this restrictive lung disease? Which of the chemotherapy
agents in the above regimen work by inducing free radicals to interfere with DNA structure? (FA13
p372) (FA14 p404) (SU14 p290)

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STEP 1 REVIEW COURSE Part 1, Set 34

5. How does flutamide differ from finasteride in terms of clinical use and mechanism of action? (FA13
p539) (FA14 p591) (SU14 p225)

6. A 3-day-old preterm infant delivered at 34-weeks gestational age develops respiratory distress
syndrome (RDS). What types of pneumocytes are affected in RDS? What is the mechanism that leads
to poor O2-CO2 exchange at the gas exchange barrier in preterm infants with RDS? What structures
make up the gas exchange barrier? How would you increase surfactant production in the pre-term
neonate? (FA13 p544, 555) (FA14 p594, 606) (SU14 p98, 103-104)

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STEP 1 REVIEW COURSE Part 1, Set 34

7. What might you observe in a patient who presents to the emergency room with PCP intoxication?
(FA13 p471) (FA14 p515) (SU14 p55)

8. Which bone is commonly fractured when a person hits something with the knuckles of a clenched fist,
causing deep pain in the anatomical snuffbox? (SU14 p244, 385) (COA p686)

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STEP 1 REVIEW COURSE Part 1, Set 34

9. How does the mechanism of action of benzodiazepines differ from the mechanism of action of
barbiturates? What toxicities of barbiturates can be fatal? (FA13 p452-453) (FA14 p493) (SU14 p46)

10. IFN- stimulates macrophages and inhibits T2 helper cells. What cell type releases IFN-? (FA13 p196)
(FA14 p201) (SU14 p261)

*Page references are as follows:

FA13: First Aid for the USMLE Step 1 2013
FA14: First Aid for the USMLE Step 1 2014
SU14: Step-Up to USMLE Step 1 2014
R: Robbins and Cotran Pathologic Basis of Disease, 8th ed. (2010)
Phys: Guyton and Hall Textbook of Medical Physiology, 12th ed. (2011)
H: Harrisons Principles of Internal Medicine, 18th ed. (2012)
COA: Clinically Oriented Anatomy, 6th ed. (2010)
GG: Goodman and Gilman Pharmacological Basis of Therapeutics, 12th ed. (2011)

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