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acids
A fatty acid is a carboxylic acid with a long aliphatic chain. Fatty acids are usually derived from
triglycerides or phospholipids. When they are not attached to other molecules, they are known
as "free" fatty acids. Fatty acids are important sources of fuel because, when metabolized, they
yield large quantities of ATP. Many cell types can use either glucose or fatty acids for this
purpose. In particular, heart and skeletal muscle prefer fatty acids.
On the other hand, Essential fatty acids, or EFAs, are fatty acids that humans and other animals
must ingest because the body requires them for good health but cannot synthesize them (2).
The term essential fatty acid refers to fatty acids required for biological processes but does not
include the fats that only act as fuel. Only two fatty acids are known to be essential for humans
like alpha-linolenic acid (an omega-3 fatty acid) and linoleic acid (an omega-6 fatty acid) (3) (4).
Some other fatty acids are sometimes classified as conditionally essential, as they can become
essential under some developmental or disease conditions such as docosahexaenoic acid (an
omega-3 fatty acid) and gamma-linolenic acid (an omega-6 fatty acid). A balance is
recommended between omega-3 and omega-6 fatty-acids, with a desirable ratio of between
1:1 and 1:3 (7).
Dosage Information
Essential fatty acid supplements might have some health benefits but it is not a proven
treatment for anything. The American Heart Association (AHA) recommends 1 g/day of EPA and
DHA for people with heart disease. Higher doses from 2-4g/day are used to lower triglycerides.
Talk to your doctor about taking a supplement first. He or she may have specific
recommendations, or warnings, depending on your health and the other medicines you take.
Your doctor can also recommend the right dose.
Conclusion
The American Heart Association has endorsed essential fatty acid benefits for the heart.
Supportive but inconclusive research shows that the consumption of EPA and DHA omega-3
fatty acids may reduce the risk of coronary heart disease. Consult your pharmacist before using
any dietary supplements.
References
1 - Theodore M. Brasky, Amy K. Darke, Xiaoling Song, Catherine M. Tangen, Phyllis J. Goodman,
Ian M. Thompson, Frank L. Meyskens Jr, Gary E. Goodman, Lori M. Minasian, Howard L. Parnes,
Eric A. Klein and Alan R. Kristal. Plasma Phospholipid Fatty Acids and Prostate Cancer Risk in the
SELECT Trial. JNCI J Natl Cancer Inst (2013) djt174 doi: 10.1093/jnci/djt174. First published
online: July 10, 2013
2 - Robert S. Goodhart and Maurice E. Shils (1980). Modern Nutrition in Health and Disease (6th
edition). Philadelphia: Lea and Febinger. pp. 134138. ISBN 0-8121-0645-8.
3 - Whitney Ellie and Rolfes SR (2008). Understanding Nutrition (11th ed.). California: Thomson
Wadsworth. p. 154.
4 - Burr, G.O., Burr, M.M. and Miller, E. (1930). "On the nature and role of the fatty acids
essential in nutrition" (PDF). J. Biol. Chem. 86 (587). Retrieved 2007-01-17.
5 - Kris-Etherton, Penny M., William S. Harris, and Lawrence J. Appel. "Fish consumption, fish
oil, omega-3 fatty acids, and cardiovascular disease." circulation 106, no. 21 (2002): 2747-2757.
6 - Harris, William S., Penny M. Kris-Etherton, and Kristina A. Harris. "Intakes of long-chain
omega-3 fatty acid associated with reduced risk for death from coronary heart disease in
healthy adults." Current atherosclerosis reports 10, no. 6 (2008): 503-509.
7 - Simopoulos, Artemis P. "The importance of the omega-6/omega-3 fatty acid ratio in
cardiovascular disease and other chronic diseases." Experimental Biology and Medicine 233, no.
6 (2008): 674-688.