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What is genes?
Genes are sections of DNA that code for the production of protein and are
arranged along the chromosomes
Carry the inherited characteristics of a person
Genes occurs in pairs, therefore each inherited characteristics is carried by
two genes
One gene from each pair comes from the father and the mother
Example of inherited characteristics carried by genes are:
-
Type of hair
Blood group
Intelligence
Chromosomes
Is a thread-like structure found in the nucleus of a cell
Chromosome and the genes on them are composed of DNA
Mitosis
Occur in somatic cells all cells body except reproductive cells
Is the type of cell division that produces genetically identical cells
During mitosis, DNA replicates in the parent cell, which divides to produce
two new cells, each containing an exact copy of the DNA as in the parent cell
This allows growth of multicellular organism from unicellular zygotes
Replacements of cells and repair of tissues is possible through mitosis
followed by cell division
Cells are constantly dying and being replaced by identical cells
Is the basis of asexual reproductionthe production of new individuals of a
species by one parent organism
Mitosis is the type of cell division that produces genetically identical cells
During mitosis, DNA replicates in the parent cell, which divides to produce
two new cells, each containing an exact copy of the DNA as in the parent cell
Cells produced are diploid (2n)
Replacement of cells and repair of tissues is possible through mitosis (Ex: cell
replacement is rapid in the skin & in the lining of the gut
Is actively carried out at the ends of plant shoots and roots
Step 1
Chromosomes thicken and shorten, and become clearly visible
Each chromosome duplicates itself and forms two chromatids attached at the
centromere
The nuclear membrane disappears
Step 2
A fibrous spindle is formed between the chromosomes
Each chromosome is attached to a spindle by its centromere
The chromosome arrange themselves at the equator of the spindle
Step 3
The centromere of each chromosome splits into two
The chromatids separate and move to opposite poles.
Step 4
A nuclear membrane is formed around the chromosomes at each pole
The cell begins to divide and form two daughter cells
Each daughter cell has the same number of chromosomes as the parent cell
In a plant cell, the cytoplasm does not constrict. Instead a new cell wall is
developed across the cytoplasm
Importance of mitosis
Important for the following reasons:
(a) Growth
(b) Replacing old or damaged cells
Enables organisms to reproduce themselves (Ex: by asexual reproduction;
binary fission in amoeba)
Ensures that the new cells produced have the same number of chromosomes
as the parent cells
Meiosis
Meiosis is the process by which a nucleus divides by two divisions into four
nuclei, each containing half the number of chromosome of the mother cell
Resulting nuclei are haploid (n)
The cells produced are genetically different to the parent cell and to each
other
Occurs in 2 stages that is meiosis 1 and meiosis 2
Produces genetic variation (caused by crossing over between homologous
chromosome)
In animals, meiosis occurs in testes and ovaries, whereas in plants, it occurs
in the anthers and ovaries
Importance of meiosis
1. Production of gamete the only process that produces gametes
2. Reduction in chromosome number ensures that each gamete has only half
the number of chromosomes of the parent cell
3. Maintenance of chromosome number in somatic cells the somatic cells have
their number of chromosomes maintained
4. Production of variation causes genetic variation in the descendants(can
produce individuals who do not resemble their parents closely)
* Variation occurs in TWO ways:
DIFFERENCES
MEIOSIS
Aim of process
To produce gametes
(reproductive cells)
Type of cell
involved
Product
Four gametes
Division of
nucleus
Duplication of
chromosomes takes place
Duplication of
chromosomes
Duplication of
chromosomes takes place
in the first cell division
Number of
chromosomes in
daughter cells
Crossing over
Combination of
chromosomes
Genetic variation
Recessive Traits
Left Handed
Short
Brown/Straight hair
Blue Eyes
Without Ear lobes
Cannot Roll Tongue
Color Blind
Has No Dimples
Non Pigmented Skin (Albino)
Short Eye Lashes
Monohybrid inheritance
Mendel chose true-breeding varieties of the garden pea as the parents
Mendel crossed a tall plant with a dwarf plant.
Progeny from this cross, called the F1 generation (first filial generation) were
all tall
All the F1 plants were then self-pollinated to obtain the F2 generation (second
filial generation)
The F2 generation included both tall and dwarf plants in the ratio of 3 tall to 1
dwarf(phenotype ratio)
It is shown that only the dominant(strong) trait appeared in the F1
generation.
The recessive (weak) trait is blocked by the strong trait from expressing itself
and is therefore hidden in the F1 generation
Genotype
TT (homozygous dominant)
Tall (monohybrid)
Tt (heterozygous)
tt (homozygous recessive)
THUS, the sex of the baby depends on which sperm fertilizes the egg
cell(ovum).
(2) Differences
Identical twins
Differences
Non-Identical twins
No of
gametes
involved
Fertilization
Division of
zygote
formed
Number of
placentas
Chromosome
s and genes
Sex of twins
Characteristi
c features
Siamese twins
Sometimes a zygote can not divides into two completely, so the two zygotes
are still linked to each other
The linked zygote develop into foetuses and are born as twins joined together
in some parts.
Siamese twins are identical twins that are formed when the two embryos do
not separate completely during the developmental stage and are attached to
one another
3.4 Mutation
Is a change in the amount or the chemical structure of DNA
Can occur spontaneously or induced by substances called mutagens
The new genetic material produced are called mutants
Mutation occur in gamete cell can be inherited
Mutation occur in somatic cell can only be inherited by daughter cells
produced by mitosis
Types of mutation
1. Chromosomal mutation
2. Gene mutation
1. Chromosomal mutation
Is the result of changes in the number or structure of chromosomes
Can cause changes in the characteristics of the organism
Changes in the no of chromosomes are usually the result of errors occurring
during meiosis or mitosis
These changes may involve the loss of a pair or a single chromosome, or the
increase in an entire haploid set of chromosomespolyploidy
Causes of mutation
1. Radioactive substances
-
Ultraviolet from the sun can destroy the cells in the skin and cause mutation
3. Chemical substances
-
4. Changes in environment
-
After a long period of time, changes in the environment can cause organisms
to adapt themselves and mutate into new species
These new species with their adapted or mutated features are most suitable
for living in the changing environment
Disadvantages
1. Can cause genetic disorder such
as albinism and haemophilia
which can be passed on future
generations
2. Plants and animals mutate in
response to adverse changes in the
environment. Mutation gives them a
better chance to survive
Variation
Each person has unique features which enable you to differentiate him or her
from other friends
No two people are exactly the same
These differences among individuals in a population or a species are called
variation
The differences may be the result of genetic differences, the influences of the
environment, or a combination of genetic and environmental influences.
In human usually the character referred to are the physical characters such
as height, weight, skin colour, etc..
The differences in physiological processes such as our blood glucose level
and immunity level are also considered
There are two types of variation:
(1) Continuous variation
(2) Discontinuous variation
Continuous Variation
The characteristics can be measured or graded on a scale such as human
heights, weight,skin colour, etc..
Cannot be grouped into distinct and discrete phenotypes
Usually quantitative (they can be measured) and are determined by genes
and influenced by environmental factors.
In *CV, a normal distribution curve is obtained
From the distribution curve, it can be seen that individuals show gradual
difference from one extreme to another extreme
There are very few individuals who are very short or very tall
Most of them are of average height
Discontinuous variation
The characters are discrete and cannot be measured or graded on a scale
such as ABO blood group, color blindness, presence or absence of
earlobe,etc..
Are qualitative(they cannot be measured or graded)
usually determined by a single gene with distinct effect.
Discrete distribution is obtained
Importance of variation