NAME: Giron, Ely Marion J.

SECTION: 2NU05

To be submitted before January 26, 2010.

Assignement: CNS drugs

FILL IN THE TABLE:

Fill in the table using the choices provided below. Write your answer in colored italics
next to the numberAnswers from the choices may be repeated or may not be used at all.

Drug Subgroup/Structure Mode of Action Indication Common

adverse effect
(1) Amphetamine-like Stimulate (2) Palpitations
cerebral cortex

Zolmitriptan (3) (4) (5) Dizziness

(6) Volatile gas Depress CNS (7) Malignant

Hyperthermia

Etidocaine (8) Depress medulla (9) Hypotension

and higher brain

(10) Non-opioid (11) (12) Hepatotoxicity

analgesic

(13) (14) Bind to opiate Severe pain Respiratory

receptors depression

Ethosuximide (15) (16) (17) Gastric irritation

Phenytoin (18) ------------- (19) Very narrow

therapeutic
range
(20) ----------------------- Inhibit dopamine (21) Nausea/vomiting
reuptake by
nerve
(22) (23) Parkinson’s Hypertensive
crisis

Tolcapone (24) (25) Hepatotoxicity

Triazolam (26) (27) (28) Hangover effect

(29) Barbiturate Alters reticular Adjunct to Constipation

formation anesthesia

(30) Muscle relaxant Depolarizes Muscle spasms Respiratory

membrane depression
CHOICES:

Column A Column B Column C Column D

(Drug) (Subgroup /Structure) (Mode of action) (Indication)
A.Dextroamphetamine A.Amphetamine A. serotonin receptor A.ADHD
B.Methylphenidate B.Ergot agonist B. obesity
C. Procaine C.Triptan B. serotonin receptor C. insomnia
D.Sumatriptan D. Amide anesthetic antagonist D. migraine
E.Enflurane E. Ester anesthetic C. Inhibit prostaglandin E. local anesthesia
F.Diazepam F. barbiturate synthesis F. general anesthesia
G.Thiopental G.narcotic agonist D. bind to opiate receptor G. mild to moderate
H.Methadone H.narcotic antagonist E.Block Na/K/Ca influx pain
I.Naloxone I.partial narcotic F. inhibit GABA release H. severe pain
J.Selegiline agonist G. stimulate GABA release I. Grand mal seizures
K.Dantrolene J.hydantoin H. inhibit MAO-B J.Petit mal seizures
L. Levodopa K.succinimide I. Inhibit COMT K. Alzheimer’s
M.Entacapone L. benzodiazepine J. depolarizes membrane L. Muscle spasms
N.Meperidine H. oxazilinedione K. blocks acetylcholine M. Parkinson’s
O.Acetaminophen
P. Bromocriptine
Q. Amantadine
R. Biperiden
Highlight your answers.

31. The following are drugs given in the preparation/induction of general anesthesia.
1 – Thiopental sodium
2- Pancuronium
3- Midazolam + Atropine
4 Diazepam PO
Which of the following is the correct order in giving the above-mentioned drugs?
A. 2-3-4-1
B. 4-3-2-1
C. 4-3-1-2
D. 4-1-3-2

32. A 19 year old female student was rushed to the E.R. due to loss of consciousness. There was
note of difficulty awakening her. Her brother found an empty bottle of Diazepam (Valium) on her
bedside prior to the incident. The drug in the bottle has the following mechanism of action:
A. Stimulation of release of epinephrine
B. Stimulation of the release of GABA
C. Inhibition of GABA release
D. Blocks acetylcholine

33. The best drug to counter the effects of the patient in number 32 is:
A. flumazanil C. flumanezil
B. flumazenil D. flumanazil

34. A 50 year old female was found to have rigid extremities, bradykinesia, and resting tremors.
All of the following are drugs which could help in her case EXCEPT:
A. vitamin B6 C. carbidopa and levodopa
B. benztropine D. amantadine

35. All of the following are drugs which depress the CNS EXCEPT:
A. pentobarbital C. midazolam
B. flurazepam D. doxapram

MATCHING TYPE: Match the following nursing considerations with the appropriate drug:

____36. Take supplements of Vitamin A, D, E, K A. phenytoin

____37. Must not be taken with grapefruit B. carbamazepine
____38. Avoid foods rich in tyramine C. almotriptan
____39. Advise that it causes darkening of sweat D. tolcapone
____40. Strictly monitor BP, RR, pupil size E. levodopa
F. phenobarbital
G. morphine
H. orlistat
I. sibutramine