Beruflich Dokumente
Kultur Dokumente
ETHNOPHARMACOLOGY
E L S E V 1E R
Abstract
As part of a larger study of the plants used by the Garifuna of eastern Nicaragua, the 229 species representing 177
genera and 72 families used for medicinal purposes were assayed for the presence of bioactive compounds. A review
of the literature for alkaloids and glycosides showed that 113 species contained at least one of these bioactive compounds. The remaining 116 species not previously cited were tested for alkaloids with Dragendorff's reagent; 51 contained alkaloids. The combined results show that 72% of the species the Garifuna use medicinally have at least one
alkaloid or glycoside. Tests to explore pharmacological activity of compounds from selected species represent the next
step to determining efficacy and application of these medicinals.
Keywords: Alkaloids; Glycosides; Garifuna; Medicinals; Ethnomedicine; Eastern Nicaragua
1. Introduction
Medicinal plants are the oldest source of pharmacologically active compounds and provided
virtually the only source of medicinally useful
compounds for centuries (Cordell, 1981). Today it
is estimated that more than two-thirds of the
world's population relies on plant-derived drugs;
some 7000 medicinal compounds used in the
Western pharmacopoeia are derived from plants
(Caufield, 1991). In the USA, approximately 25%
of all prescription drugs used contain one or more
bioactive compounds derived from vascular plants
* Corresponding author.
30
31
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Table 2
Occurrence of alkaloids and glycosides in major taxa: numbers represent species
Bioaetive
compound/source
Filicopsida
Magnoliopsida
(Dicots)
Liliopsida
(Monocots)
Total
0
1
1
86
49
135
15
1
16
I 01
51
152
Literature
Total
0
0
11
11
1
1
12
12
Grand total
146
17
164
Alkaloid
Literature
Lab/field Test
Total
Glycoside
Table 3
Presence of alkaloids in relation to habit of plant
Habit
Number of alkaloid
beating species
Herb
Vine
Shrub
Tree
66
25
18
43
43
17
12
28
Total
152
100
46
Table 4
Plant families of Garifuna medicinals with the largest number of alkaloid-bearing species
Family
Number of
species used
Reported in
literature
Lab/field results
Positive
% with
alkaloids
100
80
82
75
100
50
58
77
83
89
67
67
87
100
50
Negative
Annonaceae
Apocynaceae
Asteraceae
Boraginaceae
Convolvulaceae
Curcurbitaceae
Eupborbiaceae
Fabaeeae
Malpighiaeeae
Malvaeeae
Piperaeeae
Poaeeae
Rubiaceae
Solanaceae
Verbenaceae
4
5
11
4
4
4
12
26
6
9
6
9
8
11
6
3
0
6
1
2
I
7
15
1
4
1
6
4
9
2
1
4
3
2
2
1
0
5
4
4
3
0
3
2
1
0
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2
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0
2
5
6
1
1
2
3
1
0
3
4
4
9
3
4
2
7
20
5
8
4
6
7
11
3
Total
125
62
35
28
97
Table 6
Alkaloids/glycosides and extent of application
Popularity of medicinals
Scientific name
ASTERACEAE
Neurolaena lobata
Number
of
ailments
treated
Rating a
AlkaIoid
tests b
CUCURBITACEAE
Momordica charantia
10
EUPHORBIACEAE
Jatropha gossypiifolia
FABACEAE
Cassia alata
Cassia occidentalis
9
7
H
H
L
L
LAMIACEAE
Ocimum micranthum
MYRTACEAE
Psidium guajava
RUBIACEAE
Psychotria elata
Psychotria poeppigiana
7
8
H
H
+
+
RUTACEAE
Citrus aurantiifolia
SCROPHULARIACEAE
Scoparia dulcis
SIMARUBACEAE
Quassia amara
VERBENACEAE
Stachytarpheta cayenensis
Leading 25 species
Least used 25 species
Alkaloids/glycosides a
Present
Absent
24
17
1
8
x 2 = 4.878; P = 0.0272.
aData on glycosides are based on literature reports.
low supply in the regular food system. For example, Smilax spinosa (plant no. 228 in Table 1) is
rich in essential fatty acids, and Bromelia pinguin
(plant no. 210 in Table 1) is a good source of
minerals and vitamins. Of course, not all the
medicinals will have either traditional medicinal
value or supply the missing nutrients. Some will be
valueless, and others of importance psychologically - - certain 'prescriptions' provide healing power
simply because a respected practitioner in the community prescribed them (just as in Western
medicine).
Nonetheless, the presence of bioactive compounds in the vast majority of Garifuna
medicinals may explain their therapeutic use.
These extensive field-based studies are a necessary
first step in the search for new biologically active
molecules from natural products. Tests to explore
the pharmacological activity of the compounds are
the required next logical steps in determining the
efficacy and application of the Garifuna pharmacopoeia.
Table 7
Alkaloids/glycosides and mode of administration (nine species
could not be placed in either the oral or the topical category)
Mode of administration
47
Oral
Topical
Other
Alkaloids/Glycosides a
Present
Absent
128
33
3
45
14
6
x2 = 0.111; P = 0.7395.
aData on glycosides are based on literature reports.
48
Acknowledgements
This study was partially supported by grants
from the National Science Foundation and The
University of Connecticut Research Foundation.
We are most grateful to the Garifuna people for
sharing their ethnobotanical knowledge with us.
The field assistance of Far Blanford, Dale
DeSousa, and Rodney Martin is deeply appreciated. We thank the staffs of CIDCA (Centro
de Investigaci6n y Documentacitn de la Costa
Atl~intica) and FADCANIC (Fundaci6n Para la
Autonomia y Desarrollo de la Costa Atl~intica de
Nicaragua) for their help. Many specialists provided assistance in the identification of voucher herbarium specimens: William D'Arcy of the
Missouri otanical Garden (MO), Rupert Barneby
of the New York Botanical Garden (NY), Gerrit
Davidse (MO), James Grimes (NY), Helen Kennedy of the University of British Columbia at Vancouver (UBC), Ronald Leisner (MO), Michael
Nee (NY), Amy Pool (MO), Velva Rudd of
California State University at Northridge (SFV),
George Schatz (MO), Warren D. Stevens (MO),
Charlotte M. Taylor (MO), and Ivfin Valdespino
(NY). Thanks to Michael Edwards and Kent Holsinger for their comments on the manuscript. We
thank Ellie DeCarli and Mary Jane Spring for help
with tables and figures.
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