Welcome to the next generation

Mastersizer 3000
Smarter particle sizing

Mastersizer Particle sizing has evolved

Not just a new instrument a new Mastersizer

First Mastersizer launched in 1988

Now more than 10,000 users worldwide
Laser diffraction has become the worlds most widely
used particle sizing technique
Malvern Instruments is the global leader for particle
sizing technology and applications understanding

1988

1998

2011

The new Mastersizer 3000 at a glance

The new Mastersizer 3000 at a glance

State-of-the-art compact instrument design
Class-leading performance
10nm to 3.5mm
Rapid measurements
Robust results

Rapid and effective wet dispersion

Efficient in-line sonication

Cutting-edge dry dispersion

Suitable for fragile and cohesive samples

Software that lightens your workload

Effortless work not guess work!

Laser Diffraction: reasons for success

Wide dynamic range

From the nanometre to the millimetre size range

Rapid measurements

Results possible in less than a minute

Repeatability

Large number of particles sampled

High sample throughput

Hundreds of measurements can be made in a day

d

Calibration not necessary

Easily verified using standard reference materials

Well established technique, covered by ISO13320 (2009)

Describes general principles and expected performance

Laser diffraction how does it work?

Transmit a laser through a dispersion of particles
Angle of diffraction depends upon particle size
Large particles scatter at smaller angles
Small particles scatter light at wider angles

5 microns

800 nanometres
Images: Dr Kevin Powers, PERC, University of Florida

Mastersizer 3000 optics: red light measurements

Focal plane
detectors

Measurement cell
Back scatter
detectors

Side scatter
detectors

633nm red
laser
Precision
folded optics

Mastersizer 3000 optics: blue light measurements

Measurement cell
Back scatter
detectors

470nm blue
light source

Side scatter
detectors

Mastersizer 3000 : Delivers performance

Widest measurement range
10nm - 3.5mm measurement range
Excellent sub-micron resolution
Powerful 20mW blue solid state light source
Fast measurement times
Rapid system initialisation and measurement cycle
Sampling, measurement, cleaning in <60 secs
Robust measurements
Excellent sampling of polydisperse materials (10kHz)
Better than 1% accuracy and reproducibility

Mastersizer 3000: Wide dynamic range

10

Frequency (%)

Icing Sugar
Castor Sugar
Granulated Sugar

0
0.01

0.1

10

Size / Pm

100

1000

10000

Mastersizer 3000: Sub-micron resolution

60
30nm
46nm
100nm
220nm
500nm
700nm
1300nm
2000nm
3000nm
5000nm
9000nm

50

Volume (%)

40

30

20

10

0
0.01

0.1

Particle Size / Pm

10

Mastersizer 3000: measurement robustness

Alternating between fine and coarse samples
5

Dv10

Dv50

Dv90

Feed
Fines
100

Size / Pm

Volume (%)

10

0
0.1

10

Size / Pm

100

1000

Dv50 RSD (fine): 0.34%

Dv50 RSD (coarse): 0.7%

10

20

30

40

Measurement Number

50

60

Mastersizer 3000: Lightens your workload

Fast results and method development

Real-time optimization of each measurement

Flexible, user-independent operation

Easily switched dispersion units with auto locking cells

Automatic initialisation for robust measurements

Software that delivers your data, your way

Edit-in-place report designer

Free up bench space

Compact footprint and dispersion accessories

Top class support

Built-in intelligence - Malvern experts on-demand

Software: Measurement Manager

Measurement Manager: Observe

View measurement parameters and particle size

distribution
Instant feedback of results

Measurement Manager: Interact

Full control of all dispersion
parameters at your fingertips
Real-time control over your
method development
Change sample
documentation on the fly

Measurement Manager: Optimize

Rolling trend plotting and statistics
Rapid method optimization in line with ISO
13320 guidance

Software: viewing your results

Rapid result review

Software: simple and flexible data reporting

Simple measurement reporting

Confidential. Malvern Instruments 2011

Software: reviewing your results and methods

Accessible data
Confidential. Malvern Instruments 2011

Software: expert advice for better results

Wet or dry: a solution for every application

Wet sample dispersion Hydro range

Powerful and rapid sample dispersion

A range of sample volumes to suit your application

Dry sample dispersion Aero range

Completely new, state of the art technology

Flexibility to disperse cohesive and fragile powders

Mastersizer: Hydro wet dispersion units

All dispersion accessories:

Achieve excellent dispersion with

powerful centrifugal pump and
stirrer
Fast dispersion of cohesive
samples with in-line sonication
Chemically compatible internally
as standard
Full software control over the
sample dispersion
Integral tank light for viewing the
dispersant and sample

Mastersizer Hydro - Accessories

Hydro MV

Medium sample volume - 120ml

Fully automated cleaning

Hydro LV

Large sample volume - 600ml

Fully automated cleaning

Hydro EV

Exchangeable sample volume

250ml / 600ml / 1000ml
Easy sample recovery

Hydro MV and Hydro LV: how they work

Hydro unit measurement cell

Automatically locked into
measurement position
System recognises cell type
Windows can be quickly removed
without needing special tools
Jacketed heating/cooling for
rapid temperature stabilisation
Chemically compatible seals

Hydro EV: sampling performance

Copper powder - density 8.92 g/cm3
Stir speed titration stable >2500 rpm
180

20
Dv10
Dv50
Dv90

160

obscuration
15

140

obscuration (%)

size / Pm

120
100
80
60

10

40

-5
20
0

-10
500

1000

1500

2000

2500

stir speed / rpm

3000

3500

4000

500

1000

1500

2000

2500

stir speed / rpm

3000

3500

4000

In-line sonication : rapid and efficient dispersion

Hydro unit reproducibility

HYDRO MV

100

HYDRO EV

HYDRO LV

90
Dv10
Dv50
Dv90

size / Pm

80

70

60

50

40

30
0

10

15

20

25

30

measurement no.

Benefits of dry dispersion

Fundamentally new design state-of-the art knowledge

Fast measurement times
Excellent sampling of polydisperse materials
Flexible dispersion power - apply the appropriate
dispersion energy
Environmental and safety no solvent disposal

Aero S Dry Powder Disperser

Wide size range

0.1 Pm to 3500 Pm

Precise pressure control

0.1 to 4.0 bar

Modular venturi disperser

Standard suitable for most powders

Options for extremely cohesive or abrasive

Modular sample tray design

Adjustable sample hopper
Full software control of sample feed
and dispersion

Aero S: modular venturi for flexibility

Modular Easy Changeover
Plug-and play
Automatically recognized

Standard Venturi

Right angle design

Suitable for most types of sample

HE Venturi

Elbow design (cf. Scirocco)

High energy for very cohesive samples

Aero S: optimum sample feed

Hopper and tray assembly

Hopper vibrates with the tray

Height can be adjusted
A basket can be fitted into the hopper if required.

Configuration of the hopper and tray is auto-detected

Aero S: measurement cell

Automatically locked into
measurement position
System recognises cell type
Windows can be quickly removed
for cleaning without needing any
tool
Vacuum connection is on the
optical bench
Sheath air flow is filtered

Aero S: wide dynamic range and sampling

Coffee - polydisperse, >3mm, sticky due to oils
10
4 bar
3 bar
2 bar
1 bar
0.5 bar

Frequency (%)

0
10

100

Size / Pm

1000

Aero S: wide dynamic range

Coffee: polydisperse samples up to 3.5mm
12
Expresso
Smooth
Filter

Frequency (%)

10

0
10

100

Size / Pm

1000

Aero S: fragile samples

Sucralose is a typical fragile material
Challenge to disperse samples without breaking
primary particles
Need enough energy but not too much
Aero S standard venturi is ideal for fragile materials

Sucralose: Aero S Standard Venturi

Stable dispersion below 1.0 bar

600

Dv10
Dv50
Dv90

500

Size / Pm

400

300

200

100

0
0.0

0.5

1.0

1.5

2.0

Presure / bar

2.5

3.0

3.5

4.0

Sucralose: High Energy Venturi

600

No stable region down to 0.1 bar

Dv10
Dv50
Dv90

500

Size / Pm

400

300

200

100

0
0.0

0.5

1.0

1.5

2.0

Presure / bar

2.5

3.0

3.5

4.0

Cohesive sample: Aero S standard venturi

6

14

12

Dv10
Dv50
Dv90

Frequency (%)

Size / Pm

10

0
1

10

Measurement Number

11

12

13

14

15

0
0.01

0.1

Size / Pm

10

100

1000

Aero S: robust performance

Cement stable over a wide obscuration range
Dv10: 2.4%, Dv50: 0.5%, Dv90: 1.0%
6

60

2.13%
6.33%
9.41%
14.08%
17.42%
21.92%
37.64%

50

40

Size / Pm

Volume (%)

30

20

10

0
0.01

Dv10
Dv50
Dv90

0.1

10

Size / Pm

100

1000

10

15

20

25

Obscuration (%)

30

35

40

Mastersizer 3000: R&D Environment

High performance

Wide particle size range

Excellent sub-micron resolution

Fully flexible system

Range of dispersion accessories

to suit your sample
Easy changeover of dispersion
accessories
Build custom reports in a few
mouse clicks
Your data, your way

Easy to use

Does not require expert operator

In-built intelligence and expertise

Mastersizer 3000: QC Environment

Boost productivity and throughput
Fast measurement times
Fully automated measurement
and cleaning

Easy to use

Does not require expert operator

In-built intelligence and expertise

Robust results

Lockdown your methods with

SOPs
Validatable performance

Mastersizer 3000 - Pharmaceuticals

Highest performance
Flexibility combined with ease-of use
One platform right across the
development cycle
Easy transfer of methods from R&D
to QC

Aero S offers excellent dry

dispersion performance for fragile
materials such as actives
Full IQ/OQ/PQ validation available
CFR21 part 11 compliance

Mastersizer 3000 - Summary

High performance

Wide size range

Fast measurements
Robust results

Flexible

Range of wet and dry dispersion units

Easy changeover, auto-locking cells
Full manual control and SOP modes

Easy to use

From novice to expert

Malvern expertise inside

More Information : www.malvern.com/MS3000

Questions or Feedback?