Beruflich Dokumente
Kultur Dokumente
Department of Oral and Maxillofacial Surgery (Chair: Prof. T.E. Reichert, MD, DMD, PhD), University of Regensburg, Germany
Department of Oral and Maxillofacial Surgery (Chair: Prof. R. Sader, MD, DMD, PhD), University of Frankfurt, Germany
a r t i c l e i n f o
a b s t r a c t
Article history:
Paper received 24 March 2011
Accepted 23 July 2011
Introduction: Jaw cysts are common lesions in the oral and maxillofacial region. Enucleation of the lesions
and primary closure of the defects, the so-called cystectomy, has evolved as the treatment of choice. In
order to reduce infections and to accelerate bone regeneration, different types of bone grafts are
increasingly investigated for defect lling.
Material and methods: The present review reects the most recent studies using autogenous, allogenic,
xenogenic and alloplastic bone grafts and compares the results to current investigations about conservative cyst enucleation without using any lling materials. Relevant studies with signicant patient
sample sizes were electronically searched in PubMed and Medline.
Results: Simple cyst enucleation and blood clot healing show low complication rates and sufcient bone
regeneration even in large defects. Prospective randomized trials comparing the additional use of lling
materials to the cystectomy are rare. Currently available data do not indicate the superiority of additional bone grafts.
Conclusion: Enucleation of jaw cysts and primary closure without bone substitutes remains state of the
art in most cases.
2011 European Association for Cranio-Maxillo-Facial Surgery.
Keywords:
Jaw cysts
Enucleation
Defect lling
Bone grafts
Ossication
Complications
1. Introduction
Human bone is characterized by the unique ability to regenerate
its original structure after defects or fractures through a programmed sequence of maturation steps closely resembling the
pattern of bone development and bone growth (Schenk et al., 1994;
Buser et al., 1998). Reliable bone healing depends on an adequate
blood supply, a solid basis for bone deposition and immobilization.
During the rst 4 weeks angiogenic and osteogenic cells originating
from the adjacent bone walls and the periosteum turn a blood clot
into granulation tissue and woven bone towards the centre of the
defect. This procedure is stimulated by various cytokines, growth
factors (e.g. PDGFs, IGFs, FGFs, TGF-b, BMPs) and stem cells (Schenk
et al., 1994; Buser et al., 1998; Schliephake, 2002; Ogunlewe et al.,
2006; Rodeo et al., 2010). Over the following 4 months desmoplastic bone is replaced by parallel-bred bone resembling the
original Haversian bone structure (Lemperle et al., 1998).
q Presented at the 59th Annual Meeting of the Academy of Oral and Maxillofacial Surgery (Arbeitsgemeinschaft fr Kieferchirurgie), Bad Homburg,
Germany, 13.05.2010e14.05.2010.
* Corresponding author. Klinik und Poliklinik fr Mund-, Kiefer- und
Gesichtschirurgie, Klinikum der Universitt Regensburg, Franz-Josef-Strau-Allee
11, 93053 Regensburg, Germany. Tel.: 49 941 9446361; fax: 49 941 9446302.
E-mail address: tobias.ettl@klinik.uni-regensburg.de (T. Ettl).
1010-5182/$ e see front matter 2011 European Association for Cranio-Maxillo-Facial Surgery.
doi:10.1016/j.jcms.2011.07.023
486
Table 1
Studies investigating outcome after enucleation of jaw cysts and primary closure.
N
Location (n)
Filling (n)
Time of
follow-up
(months)
Analysis
Complication rate
Authors conclusion
209
Maxilla (161),
mandible (48)
No
12e48
Radiograph
In 4.8% wound
dehiscences with
suppuration in 3.3%
Mandible
No
6, 12, 24
Radiograph,
bone
densitometry
0%
Mandible angle
No
Radiograph
Organization of blood
clot regardless of its
volume. Depends on
optimal primary closure
Spontaneous bone
regeneration of large
cysts without lling
Chiapasco
et al. (2000)
27
160
33
Mandible;
monocortical (19),
bicortical (14)
No
2, 6, 12
Radiograph,
relative bone
densitometry
47
Mandible (29),
maxilla (16)
No
6e72
Radiograph
0%
74
No details
No
3, 6, 9, 12
Radiograph,
densitometry
Only patients
without wound
dehiscence
selected
Maxilla and
mandible
No
3, 12
Radiograph
Kreusch
et al. (2010)
417
Spontaneous bone
regeneration of large
cysts without lling
Author
cm centimetre, m months.
487
Author
488
Table 2
Studies investigating outcome after enucleation of jaw cysts and insertion of bone grafts.
Defects, main subtypes (n), size
Location (n)
Filling (n)
Time of
follow-up
(months)
Analysis
Complication rate
Bone regeneration,
outcome
Authors conclusion
Infect resistance.
Shortening of
treatment.
Accelerated bone
regeneration.
Reduced risk of
fracture
Tissue-engineered
bone as an
alternative cyst
lling material
14
Maxilla and
mandible
Autologous
(iliac spongiosa)
No details,
regularly
Radiograph
Total ossication
after 3e13 months
Pradel et al.
(2006)
22
Mandible
3, 6, 12
Radiograph,
radiodensity
Wound dehiscences in
50% of both groups
Buser and
Berthold
(1985)
65
Maxilla and
mandible
Autogenous
osteoblasts on
demineralized bone
matrix
(Osteovit, 11) vs
iliac crest (11)
Collagen
(Collagen eece)
Regularly,
no details
Radiograph
Joos (1985)
71
No details
24
Radiograph
1.5% (secondary
wound healing)
Hemprich et al.
(1989)
56
Mandible and
maxilla
Collagen (n 71) vs
control group
without lling (n
not mentioned)
Matrix collagen
Type I
Up to 8
Radiograph
Mitchell (1992)
100
Maxilla (75),
mandible (25)
No lling (50) vs
Collagen paste (50)
3, 6, 12
Radiograph,
radiodensity
No adverse reactions
for collagen. Infection
rate <5% in both groups
No details
b-TCP blood
Radiograph, CT in
12 cases; histology
in some cases
0%
Mandible
post-OP, 6,
12,
18, 24, 30
e60
1, 4, 13
Radiograph,
histology
in 16 cases
9.2% wound-healing
disturbances, partial loss of
implant in 5.9%. Total
loss in 2%
No details
3, 6, 12
Radiograph,
densitometry
Bicsak et al.
(2006)
17
Horch et al.
(2006)
52
Gerlach and
Niehues
(2007)
44
b-TCP blood;
addition of
autogenous bone
for
defects of >2 cm
Nanoparticular
hydroxyapatite
Accelerated bone
healing by collagen.
Indication for large
cysts. Collagen
superior to other
alloplastic
materials
Accelerated bone
healing by collagen
in comparison to
simple closure
Good clinical
healing and
ossication;
recommended for
cyst lling
Collagen is not
osteoinductive. No
advantage of
collagen
b-TCP facilitates
osteogenesis and
enables post-Op
implantation
Fast b-TCP
resorption and
bony substitution.
Suitable material
for lling of bone
defects
Safe resorption, low
complication rate,
rapid bone
regeneration
Holtgrave and
Spiessl
(1975)
Suitable bone
mineral substitute
for moderate-sized
defects of calvaria
and forehead bone
Partial replacement of
material by bone tissue
after 12e30 m. Complete
replacement after 30 m
Radiograph,
histology in two
cases
6e40
(average
29)
No difference in bone
density and volume
No details
Computed
tomography
3, 6
cm centimetre, m months.
Mandible,
viscerocranium
Posttraumatic defects
viscerocranium, mandibular
cysts, atrophic mandible
27
Wolff et al.
(2004)
489
No membrane (10)
vs resorbable
membrane (10)
vs non-resorbable
membrane (10)
Carbonated
apatite cement
(Norian SRS)
Mandible (17),
maxilla (13)
30
Santamaria
et al. (1998)
Radicular cysts
Mandible (32),
maxilla (20)
Gelatine sponge
(Gelfoam) (25)
vs allogenic bone
Dembone (27)
6, 12, 24
31
Dickmeiss et al.
(1985)
Maxilla (13),
mandible (18)
Humane brine
concentrate
(Tissucol)
2, 6, 12
Radiograph
Fast and
uncomplicated
regeneration also in
large cysts. Slower
bone regeneration
in older patients
Good bone
substitute for larger
defects, infection
main cause for
failure
Enhanced
osteogenesis and
prevention of
height loss by
allogenic bone
implants
No advantage for
guided bone
regeneration
490
491
492
Bezrukov VM, Grigoriants LA, Zuev VP, Pankratov AS: The surgical treatment of jaw
cysts using hydroxyapatite with an ultrahigh degree of dispersity. Stomatologiia
(Mosk) 77: 31e35, 1998
Bicsak A, Bogdan S, Barabas J, Szabo G: Medium-term study on lling large bone
defects with beta-tricalcium-phosphate (Cerasorb). J Craniomaxillofac Surg
34(Suppl. 1): 152, 2006
Blecher JC, Lemperle SM, Howaldt HP: Osteoplasty of extensive jaw defects by
protected bone regeneration using large pore resorbable implant. Mund Kiefer
Gesichtschir 4(Suppl. 2): S496eS500, 2000
Bodner L: Effect of decalcied freeze-dried bone allograft on the healing of jaw
defects after cyst enucleation. J Oral Maxillofac Surg 54: 1282e1286, 1996
Bodner L: Osseous regeneration in the jaws using demineralized allogenic bone
implants. J Craniomaxillofac Surg 26: 116e120, 1998
Bolouri S, Jonas S, Dunsche A: Die Komplikationen der Zystektomie ohne Fllung
der Knochenhhle. Deutsche Zahnrztliche Zeitschrift 56: 57e58, 2001
Boyne PJ: Application of bone morphogenetic proteins in the treatment of clinical
oral and maxillofacial osseous defects. J Bone Joint Surg Am 83-A(Suppl. 1):
S146eS150, 2001
Buser D, Berthold H: Promotion of bone regeneration using collagen eece after
defect management in voluminous jaw cysts. Dtsch Zahnarztl Z 40: 660, 1985
Buser D, Hoffmann B, Bernard JP, Lussi A, Mettler D, Schenk RK: Evaluation of lling
materials in membrane e protected bone defects. A comparative histomorphometric
study in the mandible of miniature pigs. Clin Oral Implants Res 9: 137e150, 1998
Carter TG, Brar PS, Tolas A, Beirne OR: Off-label use of recombinant human bone
morphogenetic protein-2 (rhBMP-2) for reconstruction of mandibular bone
defects in humans. J Oral Maxillofac Surg 66: 1417e1425, 2008
Chiapasco M, Rossi A, Motta JJ, Crescentini M: Spontaneous bone regeneration after
enucleation of large mandibular cysts: a radiographic computed analysis of 27
consecutive cases. J Oral Maxillofac Surg 58: 942e948, 2000 discussion 949
Constantinides J, Zachariades N: Homogenous bone grafts to the mandible. J Oral
Surg 36: 599e603, 1978
Cornell CN: Osteoconductive materials and their role as substitutes for autogenous
bone grafts. Orthop Clin North Am 30: 591e598, 1999
Dickmeiss B, Hauenstein H, Schettler D: Filling of bone defects with human brin
concentrate in large jaw cysts. Dtsch Zahnarztl Z 40: 653e656, 1985
Eunger H, Leppanen H: Iliac crest donor site morbidity following open and closed
methods of bone harvest for alveolar cleft osteoplasty. J Craniomaxillofac Surg
28: 31e38, 2000
Ewers R: Maxilla sinus grafting with marine algae derived bone forming material:
a clinical report of long-term results. J Oral Maxillofac Surg 63: 1712e1723, 2005
Friedlaender GE, Strong DM, Tomford WW, Mankin HJ: Long-term follow-up of
patients with osteochondral allografts. A correlation between immunologic
responses and clinical outcome. Orthop Clin North Am 30: 583e588, 1999
Gaasbeek RD, Toonen HG, van Heerwaarden RJ, Buma P: Mechanism of bone
incorporation of beta-TCP bone substitute in open wedge tibial osteotomy in
patients. Biomaterials 26: 6713e6719, 2005
Gerlach KL, Niehues D: Treatment of jaw cysts with a new kind of nanoparticular
hydroxylapatite. Mund Kiefer Gesichtschir 11: 131e137, 2007
Giannoudis PV, Dinopoulos H, Tsiridis E: Bone substitutes: an update. Injury
36(Suppl. 3): S20eS27, 2005
Habibovic P, Kruyt MC, Juhl MV, Clyens S, Martinetti R, Dolcini L, et al: Comparative
in vivo study of six hydroxyapatite-based bone graft substitutes. J Orthop Res
26: 1363e1370, 2008
Hall HD, Phillips RM, Chase DC: Bone grafts of large cystic defects in the mandible.
J Oral Surg 29: 146e150, 1971
He Y, Zhang ZY, Zhu HG, Qiu W, Jiang X, Guo W: Experimental study on reconstruction of segmental mandible defects using tissue engineered bone
combined bone marrow stromal cells with three-dimensional tricalcium
phosphate. J Craniofac Surg 18: 800e805, 2007
Heiple KG, Chase SW, Herndon CH: A comparative study of the healing process
following different types of bone transplantation. J Bone Joint Surg Am 45:
1593e1616, 1963
Hemprich A, Lehmann R, Khoury F, Schulte A, Hidding J: Filling cysts with type 1
bone collagen. Dtsch Zahnarztl Z 44: 590e592, 1989
Holtgrave E, Spiessl B: Die osteoplastische Behandlung groer Kieferzysten.
Schweiz Mschr Zahnheilk 85: 585, 1975
Horch HH, Sader R, Pautke C, Neff A, Deppe H, Kolk A: Synthetic, pure-phase betatricalcium phosphate ceramic granules (Cerasorb) for bone regeneration in the
reconstructive surgery of the jaws. Int J Oral Maxillofac Surg 35: 708e713, 2006
Horch HH, Steegmann B: Experience with resorbable TCP-ceramic granules for the
lling of large bone defects after cystectomy in the jaw. Dtsch Zahnarztl Z 40:
672e677, 1985
Horowitz I, Bodner L: Use of xenograft bone with aspirated bone marrow for
treatment of cystic defect of the jaws. Head Neck 11: 516e523, 1989
Huh JY, Choi BH, Kim BY, Lee SH, Zhu SJ, Jung JH: Critical size defect in the canine
mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100: 296e301, 2005
Iatrou I, Theologie-Lygidakis N, Leventis M: Intraosseous cystic lesions of the jaws
in children: a retrospective analysis of 47 consecutive cases. Oral Surg Oral Med
Oral Pathol Oral Radiol Endod 107: 485e492, 2009
Ihan Hren N, Miljavec M: Spontaneous bone healing of the large bone defects in the
mandible. Int J Oral Maxillofac Surg 37: 1111e1116, 2008
Jensen SS, Bornstein MM, Dard M, Bosshardt DD, Buser D: Comparative study of
biphasic calcium phosphates with different HA/TCP ratios in mandibular bone
defects. A long-term histomorphometric study in minipigs. J Biomed Mater Res
B Appl Biomater 90: 171e181, 2009
493