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Alzheimer's disease
Scientists found that curcumin was able to reduce deposits of beta-amyloid
proteins in the brains of elderly lab mice that ate it as part of their diets.
Furthermore, when the researchers added low doses of curcumin to human betaamyloid proteins in a test tube, the compound kept the proteins from aggregating
and blocked the formation of the amyloid fibers that make up Alzheimer's plaques.
Arthritis
Email testimonial - I began taking 1 gram of tumeric curcumin several years ago for
possible Alzheimers prevention. Both my father and& father-in-law have it.
Recently, I came across several articles about the anti-inflammatory properties
being tested for arthritis as well, and decided to increase my dose to 2 gms per
day. I had been experiencing arthritic pain in my thumb and hip for over a year, and
was concerned about the NSAIDs I was taking at increasing doses and
frequencyas well as the very limited relief I was getting. I was already taking
1500mg glucosamine 1200mg / chondroitin / MSM daily. After a week or two at the
2 gm dose, my arthritis pain is virtually gone and I havent taken any other NSAIDs.
Cancer, helping reduce tumors or prevention
Increase in plasma concentrations of geranylgeranoic Acid after turmeric tablet
intake by healthy volunteers.
J Clin Biochem Nutrition. 2010.
Geranylgeranoic acid (GGA) is one of the most potent cancer-preventive acyclic
retinoids. GGA has been shown to induce cell death in human hepatoma-derived
HuH-7 cells. We have recently reported the natural occurrence of GGA and its
related compounds in several medicinal herbs such as turmeric, basil, rosehip,
cinnamon and others. In the present study, we performed oral administration of
turmeric tablets to healthy volunteers in order to investigate bioavailability of
natural GGA. With healthy volunteers, plasma GGA was detected prior to the tablet
intake and its concentrations were increased at 2 h after its intake and maintained
at higher level until 4 h, suggesting an efficient bioavailability of preformed GGA in
the turmeric tablets through oral administration. These results indicated that GGA
in the turmeric tablet was absorbed as an intact form from intestinal mucosa.
Bharat Aggarwal of the Department of Experimental Therapeutics at the University
of Texas M.D. Anderson Cancer Center in Houston, says. "What's exciting about
this agent is that it seems to have both chemopreventive and therapeutic
properties. Bharat Aggarwal injected mice with human breast cancer cells -- a
batch of cells grown from a patient whose cancer had spread to the lungs. The
resulting tumors were allowed to grow, and then surgically removed, to simulate a
mastectomy. Then the mice either got no additional treatment; curcumin alone; the
cancer drug paclitaxel, which is sold under the brand name Taxol; or curcumin plus
Taxol. Half the mice in the curcumin -only group and 22 percent of those in the
curcumin plus Taxol group had evidence of breast cancer that had spread to the
lungs. But 75 percent of animals that got Taxol alone and 95 percent of those that
got no treatment developed lung tumors. Earlier studies suggest that people who
eat diets rich in turmeric have lower rates of breast cancer, prostate cancer, lung
cancer and colon cancer. His team would like to try giving turmeric to women with a
high risk of breast cancer -- such as those who have a mother or sister with the
disease. No drug company is likely to develop a natural product that cannot be
patented, he said. "There are no companies behind it so our only source of funding
is either the National Institutes of Health or the Department of Defense," he said.
This study was funded by the U.S. Department of Defense's Breast Cancer
Research Program.
Skin cancer
Curcumin interferes with melanoma cells. Tests in laboratory dishes show that it
made melanoma skin cancer cells more likely to self-destruct in a process known
as apoptosis. The same research team has found that turmeric helped stop the
spread of breast cancer tumor cells to the lungs of mice. The turmeric suppressed
two proteins that tumor cells use to keep themselves immortal. People who eat
plenty of turmeric have lower rates of some cancers.
Heart health, cardiovascular system
Protective effects of Curcuma longa on ischemia-reperfusion induced myocardial
injuries and their mechanisms.
Life Sci. 2004.
Wistar rats were divided into three groups and received saline orally (sham,
control I/R group) and Turmeric 100 mg/kg respectively for one month. On the 31st
day, rats of the control I/R and turmeric treated groups were subjected to 45 min of
occlusion of the LAD coronary artery and were thereafter reperfused for 1 h. I/R
resulted in significant cardiac necrosis, depression in left ventricular function,
decline in antioxidant status and elevation in lipid perodixation in the control I/R
group as compared to sham control. Myocardial infarction produced after I/R was
significantly reduced in the turmeric treated group. Cardioprotective effect of
turmeric likely results from the suppression of oxidative stress and correlates with
the improved ventricular function.
I read about its abilities to help in cases such as arthritis. I have arthritis or I
wouldnt be asking the most vital question which is, is turmeric safe enough for a
heart transplant patient to take?
I am not sure. It may depend on the types of medications a person is on. I have
not seen studies regarding its use in cases of heart transplant patients.
Rheumatoid arthritis
Efficacy and mechanism of action of turmeric supplements in the treatment of
experimental arthritis.
Arthritis Rheum. 2006.
A curcuminoid containing turmeric extract was administered intraperitoneally to
female Lewis rats prior to or after the onset of streptococcal cell wall-induced
arthritis. In vivo treatment prevented local activation of NF-kappaB and the
subsequent expression of NF-kappaB-regulated genes mediating joint
inflammation and destruction, including chemokines, cyclooxygenase 2, and
RANKL. Consistent with these findings, inflammatory cell influx, joint levels of
prostaglandin E(2), and periarticular osteoclast formation were inhibited by
treatment.
Turmeric extracts containing curcuminoids prevent experimental rheumatoid
arthritis.
J Nat Prod. 2006.
Turmeric side effects, adverse events, caution
Various cultures, particularly people living in India, have used turmeric powder for
centuries or millennia. Turmeric supplements have been available much less time
as medicinal drugs in Western countries. No major turmeric side effects have been
reported in the medical literature. Taking too many turmeric capsules may increase
body temperature. For long term use, one to three turmeric capsules a day should
not present any major problems. Some people may be taking several turmeric
curcumin capsules a day for the treatment of a particular medical condition as
advised by their health care provider. Side effects of high dose turmeric curcumin
use of several months or years is not clear. We also don't know what kind of
turmeric side effects would occur when high doses of this herb is combined with
prescription medications. There is a possibility that high dose turmeric ingestion
leads to high oxalic acid in the urine leading to kidney stones.
Effect of cinnamon and turmeric on urinary oxalate excretion, plasma lipids, and
plasma glucose in healthy subjects
American Journal of Clinical Nutrition, 2008.
Eleven healthy subjects participated in an 8-week, randomly assigned, crossover
study that involved the ingestion of supplemental doses of cinnamon and turmeric
for 4-wk periods that provided 55 mg oxalate/d. Oxalate load tests, which entailed
the ingestion of a 63-mg dose of oxalate from the test spices, were performed after
each 4-wk experimental period and at the study onset with water only (control
treatment). Compared with the cinnamon and control treatments, turmeric ingestion
led to a significantly higher urinary oxalate excretion during the oxalate load tests.
My mother in law used turmeric supplement for a few weeks and now has itching.
She has melanoma.
This is the first we have heard of this possible relationship between turmeric and
itching. The best option is to stop the turmeric for a couple of weeks and under
medical guidance to reintroduce it in small amounts to see if the turmeric was the
cause or whether it was something else coincidentally causing the itching, perhaps
other supplements she is taking or medicines, or a medical condition.
In general terms, do the anti-inflammatory benefits of turmeric act as NSAIDs do in
terms of compounding hypertensive issues? I understand that NSAIDs affect
hypertensive people by rendering their anti-hypertensives ineffective. Does
Turmeric either act in this manner, or contribute to elevated blood pressures in the
non-medicated person? If those people with variety of arthritis problems plus
hypertension could take Turmeric, it would be such a blessing. This is one issue
that I do not see discussed in my turmeric research, and would be very helpful if
published.
We have not come across any meaningful research regarding the role of turmeric
in blood pressure.
Can a person with Hepatitis B or Hepatitis C take a turmeric supplement?
Probably, if their doctor approves. But I don't know how it interacts with liver cells
in those with hepatitis.
Could you please tell me if 'ground turmeric spice will work just as well as the
capsules? I have been mixing it and ginger and drinking it, for quite some time
(yuck, but I'll do anything to help the IBS & prevent cancer, as it is raging in my
family.
Ground turmeric is very beneficial and would be similar to the that ingested as a
capsule. However, the curcumin / turmeric product by Physician Formulas has a
95% turmeric extract for curcumin which provides a high amount of this beneficial
substance. Ground turmeric used as a condiment usually has 5 percent or so of
curcuminoids. However, if a high amount of ground turmeric spice is used, it could
be just as good as taking a curcumin / turmeric capsule.
I am a 70 year old male and have had psoriasis for over 40 years. It has
progresses to approximately 20 percent coverage. I began having minor arthritis
symptoms in my shoulder and hands about 3 years ago. I began taking 2 grams of
turmeric in capsule following one 10mg of Bioperine 3 times per day 5 months ago.
My arthritis is practically non existent. I was taking 800 mg of Ibuprofen each
morning to alleviate the pain. I take none now! My psoriasis has improved probably
70 percent with practically no scaling, a great reduction in redness and almost no
itching. ( I sometimes catch myself itching out of habit alone since I clawed myself
daily for years). There is continued noticeable improvement. I take no medications.
I am blessed that I have never been hospitalized. I wish the benefits of turmeric
could be trumpeted to all. Of course, we know that the many medical studies that
could prove the benefits of turmeric will never be done because there is no way for
the huge money hungry drug companies to benefit from a non patented cure or at
least greatly beneficial product. You are authorized to use my experience in any
manner you see fit in order to make others aware of Turmeric. I applaud your
internet postings as to the known and possible benefits of turmeric.
Does the curcumin capsules you provide contain more curcuminoids than the
turmeric you purchase from stores? How many tsp's (or another unit of measure)
do the capsules equal compared to turmeric powder? Is it higher quality or it it the
same? If it is higher quality, before i order, i still need to know how many capsules
would equal how much turmeric to get my dosing correct.
This supplement has 250 mg of turmeric extract and 250 mg of turmeric powder.
The turmeric extract is 95% curcuminoids, therefore, 95% of the 250 mg turmeric
extract is curcumin, which is about 238 mg. Turmeric powder itself is only 5%
curcumin. Therefore 5% of 250 mg of the turmeric is curcuminoids, which makes it
about 12 mg. in total, this curcumin-turmeric supplement has a total of 500 mg of
which about 250 mg is pure curcumin. We provide the highest curcumin quality we
can find.
Read your stuff on curcumin. Do you know if turmeric is equally effective, and if so
what dosage is correct (for general cancer and brain protective functions)? I live in
Cambodia where turmeric is easy enough to find, but I doubt if anyone has ever
heard of curcumin extract capsules or the like. (And there is no mail delivery.)
Turmeric contains small amounts of curcumin and other substances. Most
curcumin supplements have a very high extract of turmeric. Even though the
turmeric extract curcumin is much more potent that turmeric alone, turmeric itself
has health benefits. The appropriate dosage to prevent or treat various health
conditions is not clear. Practically speaking one should use turmeric to the extent
that it makes their food palatable. It is also possible to perhaps mix some in juice
and ingest it that way.
Is it alright to take turmeric with Lipitor or a statin drug if so how much I can get the
spice powder not sure of tablets.
Although small amounts of this spice should be safe with Lipitor, Zocor or any
statin drug, it is not easy to give blanket statements since each person is different
in their response and reaction.
Given that many herbs such as tumeric have been used in large doses for
thousands of years by millions in India, isn't that a better safety criteria than a six
month clinical drug trial by some pharmaceutical company who has a vested
interest in the outcome?
Yes, the historical use of an herb needs to be seriously taken into account as
part of a holistic understanding of the benefits and harm.
TRADUCCION:
Artritis
Testimonial del correo electrnico - comenc a tomar 1 gramo de Crcuma
Curcumina para la prevencin de la enfermedad de Alzheimer posible hace varios
aos. Tanto mi padre y & suegro tenerlo. Recientemente, vino a travs de varios
artculos sobre las propiedades antiinflamatorias ensayadas para as como la
artritis y decidi aumentar mi dosis a 2 gms al da. Yo haba estado
experimentando dolor artrtico en mi pulgar y mi cadera para ms de un ao y
estaba preocupado por los AINE iba a aumentar las dosis y la frecuencia... as
como el relieve muy limitado que empezaba. Ya estaba tomando Glucosamina
1500mg 1200mg / condroitina / MSM diariamente. Despus de una semana o dos
en la dosis de 2 g, mi dolor de la artritis es virtualmente desaparecido y no he
tomado ningn otro AINE.
Cncer, ayudando a reducir los tumores o prevencin
Aumento de las concentraciones plasmticas de cido geranylgeranoic despus
de la ingesta de la tableta de crcuma por voluntarios sanos.
J Clin Biochem nutricin. 2010.
Geranylgeranoic cido (GGA) es uno de los ms potentes retinoides acclicos
preventiva contra el cncer. GGA ha demostrado para inducir la muerte celular en
clulas derivadas de hepatoma humanas de HuH-7. Recientemente hemos
divulgado la ocurrencia natural del GGA y sus compuestos relacionados en varias
hierbas medicinales como la crcuma, la albahaca, rosa mosqueta, canela y otros.
En el presente estudio, se realiz la administracin oral de comprimidos de
crcuma en voluntarios sanos con el fin de investigar la biodisponibilidad del GGA
natural. Con voluntarios sanos, plasma GGA fue detectada antes de la ingesta de
la tableta y sus concentraciones se aument a 2 h despus de su admisin y
mantenidas en el nivel superior hasta las 4 h, sugiriendo una biodisponibilidad
eficiente de preformado GGA en las tabletas de crcuma a travs de la
administracin oral. Estos resultados indicaron que GGA en la tableta la crcuma
fue absorbido como una forma intacta de la mucosa intestinal.
Bharat Aggarwal del Departamento de Teraputica Experimental en la Universidad
de Texas M.D. Anderson Cancer Center en Houston, dice. "Lo emocionante de
este agente es que parece que tiene propiedades tanto quimiopreventivos y
teraputicas. Bharat Aggarwal inyect a ratones con clulas de cncer de mama
humano--un lote de las clulas cultivadas de un paciente cuyo cncer se haba
extendido a los pulmones. Los tumores resultantes fueron permitidos para crecer y
luego quirrgicamente, para simular una mastectoma. Entonces los ratones
tampoco no tienen ningn tratamiento adicional; curcumina sola; el cncer droga
paclitaxel, que se vende bajo la marca Taxol; o curcumina ms Taxol. Mitad de las
ratones en la curcumina-grupo y 22 por ciento de los de la curcumina ms Taxol
grupo tuviera evidencia de cncer de mama que se haba propagado a los
pulmones. Pero el 75 por ciento de los animales que solo Taxol y 95 por ciento de
los que ningn tratamiento desarrollaron tumores pulmonares. Estudios anteriores
sugieren que las personas que consumen dietas ricas en crcuma tienen tasas
ms bajas de cncer de mama, cncer de prstata, cncer de pulmn y cncer de
colon. Su equipo le gustara probar a las mujeres con un alto riesgo de cncer de
hipertensin podran tomar crcuma, sera una bendicin. Esto es un tema que no
veo discutido en mi investigacin de crcuma y sera muy til si publica.
No hemos venido a travs de cualquier investigacin significativa con respecto al
papel de la crcuma en la presin arterial.
Una persona con Hepatitis B o Hepatitis C puede tomar un suplemento de
crcuma?
Probablemente, si su mdico lo aprueba. Pero no s cmo interacta con las
clulas del hgado en pacientes con hepatitis.
Por favor podra decirme si ' tierra crcuma especia funcionar tan bien como las
cpsulas? He estado mezclando y jengibre y bebiendo, desde hace algn tiempo
( Puaj, pero lo har cualquier cosa para ayudar el SII y prevenir el cncer, como
es en mi familia.
Tumrico molido es muy beneficioso y sera similar a la que se ingiere en forma de
cpsulas. Sin embargo, la curcumina producto crcuma por frmulas mdico tiene
un extracto de crcuma de 95% de curcumina, que proporciona una alta cantidad
de esta sustancia beneficiosa. Crcuma molida utiliza como condimento
generalmente tiene 5 por ciento o menos de curcuminoides. Sin embargo, si se
utiliza una alta cantidad de suelo crcuma especia, que podra ser tan bueno como
tomando un curcumin / cpsula de crcuma.
Soy un hombre de 70 ao de edad y han tenido psoriasis desde hace 40 aos.
Tiene progresa a aproximadamente 20 por ciento de cobertura. Empec a tener
sntomas de artritis menor en mi hombro y manos hace unos 3 aos. Comenc a
tomar 2 gramos de crcuma en cpsula siguientes 10 mg de Bioperina 3 veces al
da hace 5 meses. Mi artritis es prcticamente inexistente. Estaba tomando 800
mg de ibuprofeno cada maana para aliviar el dolor. Ahora tomo ninguno! Mi
psoriasis ha mejorado probablemente prcticamente sin ajuste de escala, una
gran reduccin de enrojecimiento y casi sin picazn el 70 por ciento. (A veces veo
yo mismo prurito por costumbre solo desde que me ara diariamente durante
aos). Existe una continua mejora notable. No tomar ningn medicamento. Es
una bendicin que yo nunca he sido hospitalizado. Ojal que los beneficios de la
crcuma pueden ser proclamados a todos. Por supuesto, sabemos que los
muchos estudios mdicos que podran demostrar que los beneficios de la crcuma
no se har nunca porque es imposible para que las compaas de drogas hambre
mucho dinero en beneficio de un no patentado cura o producto menos
enormemente beneficioso. Usted est autorizado a usar mi experiencia en
cualquier manera que creas conveniente con el fin de hacer conciencia de la
crcuma. Aplaudo sus anuncios de internet en cuanto a los conocidos y posibles
beneficios de la crcuma.
Las curcumina cpsulas que contiene curcuminoides ms que usted compra en
tiendas de la crcuma? De cuntas cucharaditas (u otra unidad de medida) las
cpsulas igual comparadas con el polvo de la crcuma? Es ms de alta calidad o
es lo mismo? Si es ms de alta calidad, antes de que orden, necesita saber
cuntas cpsulas igualara cunto crcuma para conseguir mi dosificacin
correcta.
Este suplemento tiene 250 mg de extracto de crcuma y 250 mg de polvo de la
crcuma. El extracto de crcuma es 95% de curcuminoides, por lo tanto, el 95%
de los 250 mg de extracto de crcuma es la curcumina, que es aproximadamente
238 mg. polvo de la crcuma se es la curcumina, slo 5%. Por lo tanto es de 5%
de 250 mg de la crcuma curcuminoides, que hace unos 12 mg. en total, este
suplemento curcumin-crcuma tiene un total de 500 mg de los cuales unos 250
mg es la curcumina pura. Ofrecemos la ms alta calidad de curcumina que
podemos encontrar.
Leer tus cosas en curcumina. Sabes si la crcuma es igualmente eficaz, y si es
as qu dosis es correcta (para funciones protectoras cerebro y cncer
generales)? Yo vivo en Camboya donde la crcuma es bastante fcil de encontrar,
pero dudo si alguien ha odo hablar de curcumina extracto cpsulas o similares. (Y
no hay ninguna entrega de correo).
La crcuma contiene pequeas cantidades de curcumina y otras sustancias.
Mayora de los suplementos curcumina tiene un muy alto Extracto de crcuma.
Aunque el extracto de la crcuma curcumina es mucho ms potente que la
crcuma sola, crcuma s mismo tiene beneficios para la salud. La dosis adecuada
para prevenir o tratar varias condiciones de salud no est clara. Prcticamente
hablando uno debe usar la crcuma en la medida en que hace su comida sabrosa.
Tambin es posible tal vez algunos en jugo de la mezcla e ingieren as.
Est bien que tome la crcuma con Lipitor o una droga estatina si cunto puedo
conseguir el polvo de la especia no est seguro de las tabletas.
Aunque pequeas cantidades de esta especia deben ser seguros con Lipitor,
Zocor o cualquier droga estatina, no es fcil dar declaraciones manta ya que cada
persona es diferente en su respuesta y de reaccin.
Dado que muchas hierbas como la crcuma se han utilizado en grandes dosis
durante miles de aos por millones en la India, es un criterio de seguridad mejor
que un mes seis clnicas ensayo clnico por una compaa farmacutica que tiene
mucho inters en el resultado.
S, el uso histrico de una hierba debe ser tomado seriamente en cuenta como
parte de una comprensin holstica de los beneficios y daos.
Original
Does it play a role as an anti-inflammatory substance?