Pathophysiology

HTH SCI 4K03. Fall 2013

HTH SCI 4K03 Pathophysiology I, Fall 2013

Course Description and Outline

Course Dates/time: see calendar at the end of the document

Course Instructor and Coordinator:

Thomas Hawke, PhD

Recommended Text:
Pathophysiology of Disease, An Introduction to Clinical Medicine, 6th Edition. Stephen J.
McPhee, Gary D. Hammer
ISBN: 0-07-162167-9

Course Description:
Summary: The course is intended to provide students with an introduction to various disease
states with a focus on the aberrant physiology. The course consists of lectures, tutorials and labs
with an overall intention to provide the student with multiple different avenues to investigate
pathophysiology. Lectures will be provided by Dr. Hawke and special guest lecturers who are
clinicians working in the specific areas we are studying in this course.
The lectures will not only enhance the students understanding of selected pathologies, but will
provide them with a unique opportunity to hear from clinicians about their experiences in a
specific area of interest.
Tutorials will be an opportunity to work in small groups solving case studies in a time-
constrained manner. These case study based tutorials are intended to be challenging and
engaging (and hopefully fun!)- forcing groups to reason through problems in a time sensitive
manner.
Lab sessions will provide students with hands-on opportunities to understand and investigate
the (patho-)anatomy underlying a variety of disease states investigated in this course. The
highlight of the Lab sessions will be the preparation of an patho-anatomy module which will be
resource to all present and future students of Mac Anatomy.

Lectures:
1 hour/week:
The purpose of the lectures will be to introduce the basic concepts in normal physiology and
discuss perturbations to this normal pattern in disease states. Through the introduction and
discussion of the material in this way, the students should gain and understanding and
appreciation of how to reason through case studies. The second lecture within each
Pathophysiology area will be presented by a clinician who will provide the student with insight
into a specific disease state of interest to that clinician.

Tutorials:
1 hour/week:
The purpose of the tutorials is for the students to, in a group setting, work through case studies.
The topic area of the case study is noted in the course calendar provided and will be generally-
associated with the lecture discussions that week.

Pathophysiology HTH SCI 4K03. Fall 2013

Each week, students will be presented with a specific case study related to the area of focus for
that week (see attached course itinerary). Students (working in groups) will have 35 minutes to
address two problems associated with the case study:
Students will not be allowed to use laptops for the first 10 minutes of the 35 minute timeslot. It is
during this time that they are expected to use their background knowledge to help focus/refine
their search.
One student from each of three groups, chosen at random, will present a brief synopsis (5 min) of 1
and 2, respectively. The third group will be responsible for addressing the validity of the answers
provided and/or noting flaws in the logic, and, when applicable, tests that may be done to further
confirm diagnosis.
>>Groups will be graded on their reasoning and logic into solving the case study as well as their in-
group and in-class participation as determined by the Teaching Assistant<<
***Note: These tutorials will be challenging. It is intended to promote problem solving in a
time-limited fashion, reasoning and team work. Oral presentations are meant to be brief and
thus the necessity for being clear and concise- The logic underlying how you arrived at
answer should be evident in your presentation.

Labs:
Labs are held biweekly. Prior to each lab, students will be required to review a defined online
pathology module (MacAnatomy). Upon commencement of the lab, all students will be required
to write a small quiz (IRAT or Individual Readiness Assurance Test) which will be graded and
those marks included in their final grade.
While there will be no specific final lab exam, materials from the lab component can and will be
used in the midterm and final written exam.
Module preparation: Within the lab, students will be broken into groups (different groups from
their tutorial groupings) and will create a novel module based on specimens within the
anatomy lab. This module preparation will generate a written document (to be used within the
anatomy lab). Presentation of the module will take place in the final lab session of the semester.
Groups will receive oral and written feedback of their module (based on the presentation) so
they may make any improvement, if necessary, prior to handing it in during their final tutorial
session.

Pathophysiology HTH SCI 4K03. Fall 2013

Marking Scheme:

Midterm Exam:
15%
Final Exam:
25%

Tutorial Marks:
15% (3 presentations @ 3% each; plus 6% for overall participation)
Laboratory Quizzes 10% (5 quizzes @ 2% each)
Module Preparation 35% (10% module presentation, 25% for written document)
Total Marks: 100%

Scoring Rubric:
Midterm & Final Exam- multiple choice, short answer, reasoning. Material taken from lecture,
tutorial and lab components.
Tutorial- Participation is defined as the interaction/activity of students within their groups as
defined by the tutor/TA. Each student within the group will receive the same score for the
presentation mark.
Laboratory quizzes: multiple choice/short answer based on online pathology module viewed in
advance.
Pathology Module preparation: Students will be provided with an example modules from which
to frame their novel module. The groups are free to choose any pathology they wish provided it
is not already available within the lab. It is strongly encouraged that students incorporate as
much of the internal material (specimens, models, etc. within the anatomy lab) into their module
as possible rather than relying heavily on external images from the internet/textbooks.
Presentation of the module will take place in the final lab session. Presentation will last 15 min
with 5 minutes for questions from the audience. The presentation will account for 10% of the
final mark. The remaining 25% of the final mark will be for the written Pathology Module that
will be handed in during the final tutorial session. This will be graded on originality, accuracy
and completeness of descriptions, inclusion of specimen examples, appropriateness and
completeness of references.


**Late penalties will apply (see assignments for more details). You should complete a McMaster
Student Absence Form (MSAF) if you will require an extension due to a minor medical situation
that you expect to last for up to five days. If you will be absent for reasons other than medical
reasons, or your medical absence will be more than five days, or you have already exceeded one
MSAF request in the term, then you MUST visit your Associate/Assistant Dean's Office (Faculty
Office) to request an extension. You may be required to provide supporting documentation to
the Dean. If I do not receive an MSAF from you, or the Deans Office does not contact me with a
request to give you an extension, then you will lose points due to lateness.

Grades will be assigned according to the following conventional scheme:
90-100 A+
70-72 B-
53-56 D
85-89 A
63-66 C
50-52 D-
80-84 A-
67-69 C+
0-49 Fail
77-79 B+
60-62 C-
73-76 B
57-59 D+
The instructor reserves the right to adjust final marks up or down based on the performance of
the class as a whole. In the course of performing due diligence with appropriate sensitivities to

Pathophysiology HTH SCI 4K03. Fall 2013

the issue of marks, we review all materials with particular emphasis at breakpoints, e.g.,
between 82-85 and 86-89. If you want a higher mark, you can formally appeal through regular
channels.


Behaviour in Classes
Respect for everyone else is crucial to providing an atmosphere for learning.
Distractions take away from learning, and you must make sure you do not cause any. Computers
in the lectures are for note-taking or referring to course material; they must not be used for other
(e.g. social networking/emailing) purposes. Likewise, other electronic devices must all be turned
off.

Academic Dishonesty
Academic dishonesty consists of misrepresentation by deception or by other fraudulent means
and can result in serious consequences, e.g. the grade of zero on an assignment, loss of credit
with a notation on the transcript (notation reads: Grade of F assigned for academic dishonesty),
and/or suspension or expulsion from the university. It is your responsibility to understand what
constitutes academic dishonesty. For information on the various kinds of academic dishonesty
please refer to the Academic Integrity Policy, specifically Appendix 3, located at
http://www.mcmaster.ca/senate/academic/ac_integrity.htm The following illustrates only three
forms of academic dishonesty: 1. Plagiarism, e.g. the submission of work that is not ones own or
for which other credit has been obtained. 2. Improper collaboration in group work. In this course,
while students may work together on assignments, each student must have his/her own data
base and must conduct his/her own analyses and writeups. 3. Copying or using unauthorized
aids in tests and examinations. Formulas will be provided on the exam. The Standard McMaster
Calculator may be used. Note: The instructor, program and the university reserve the right to
modify elements of the course during the term. The university may change the dates and
deadlines for any or all courses in extreme circumstances. If modifications become necessary,
reasonable notice and communication with the students will be given. Students will be provided
with an explanation and an opportunity to comment. It is the responsibility of students to check
their McMaster email and the course website/LearnLink weekly during term. Any significant
changes will be made in consultation with the BHSc Assistant Dean.

Pathophysiology HTH SCI 4K03. Fall 2013

Topics for Consideration:

Cardiac:
1. Basic Anatomy & Physiology
2. Diseases:
Chronic Heart Failure
LV failure, RV failure
Valvular Heart Disease
Aortic & Mitral Stenosis
Aortic & Mitral Regurgitation
Coronary Artery Disease

Musculo-Skeletal (MSK):
1. Basic Anatomy & Physiology
2. Diseases:
Muscle
Muscular Dystrophies, Mitochondrial Myopathies, Inflammatory Myopathies
Tendon
Achilles Tendon Injury
Bone
Arthritis

Renal:
1. Basic Anatomy & Physiology
2. Diseases:
Acute Kidney Injury
Chronic Renal Failure
Glomerulonephritis and Nephrotic Syndrome
Renal Stones


Endocrine:
1. Basic Anatomy & Physiology
2. Diseases:
Endocrine pancreas
Type 2 DM and obesity
Hypothalamic pituitary axis

Neoplasia:
1. Definition, classification, characteristics of benign and malignant tumours.
2. Effects and complications of benign and malignant tumours.
3. Diagnosis of tumours and tumour markers.

These are topics that you may be exposed to during lectures, tutorials and lab sessions. This is by
no means a complete list.

Pathophysiology HTH SCI 4K03. Fall 2013

Monday
SEPT 2

Tuesday
3

Wednesday Thursday
4
5

Friday
6

10

11

13
LAB
Cardiovascular
20

LEC1

16

Intro -TJH

17

23

CV -TJH

24
CV -DP

MSK

switched to tutorial
15

16

LEC1-

-no classes
21

Renal -TJH

22

28

LEC1

17
Renal case
Renal case

30

31

- no classes
7
TUT1- Endo case

13

14

Endo -HF

19

TUT1-

20

LEC1-

Neoplasia-

26
LEC1

DEC 2

21
TUT1-

27
Neoplasia-JJ

3
LEC1-

25
LAB
Endocrine
NOV 1

Neo case

no lecture

28
TUT1-

8
LAB
Neoplasia
15

Endo case

TJH
25

11
LAB
Renal
18

24
TUT1-

Endo -TJH

12
LEC1-

18

MSK MT
Switched to lecture
10
TUT1- MSK case

27
LAB
Musculoskeletal
4

MIDTERM

LEC1-

11

PM

29

TUT1-

23

LEC1-Renal

CV case

TUT1-

LEC1-

14

CV case

26
TUT1-

OCT 1
LEC1- MSK -TJH

Intro

19
TUT1-

25

LEC1-

30

TUT1-

18

LEC1-

12

22
LAB
Module
Presentations
29

Submit
during

modules
class time
Lecturer: TJH: Dr. Hawke; DP: Dr. Predescu; MT:
Dr. Tarnopolsky; PM: Dr. Margetts; HF: Dr. Faraji;
JJ: Dr. Jansen;

Pathophysiology HTH SCI 4K03. Fall 2013

Monday
SEPT 2

Tuesday
3

Wednesday Thursday
4
5
LEC2- Intro-TJH

Friday
6

10

11

13
LAB
Cardiovascular
20

TUT2-

16

17
TUT2-

23

7
14

15
22

18

25
DEC 2

- no classes
7
LEC2- Endo -TJH

13

14
LEC2-

20
Endo case

26
TUT2-

31

Endo case

19
TUT2-

MIDTERM

30

no tutorial

12
TUT2-

Renal -PM

24
LEC2

11
LAB
Renal
18
25
LAB
Endocrine
NOV 1

no tutorial

5
TUT2-

11

23

Renal -TJH

17
LEC2-

Renal case

29
TUT2-

Renal case

27
LAB
Musculoskeletal
4

MSK -MT

10
LEC2-

16

MSK --TJH

3
LEC2-

MSK case

CV -DP

26
LEC2-

TUT2-

28

25
CV case

CV -TJH

19
LEC2-

TUT2-

-no classes
21

CV case

OCT 1
TUT2- MSK case
TUT2-

12
LEC2-

18

24
TUT2-

30

Intro

27
Neo case

8
LAB
Neoplasia
15

Endo -HF

21

22
LEC2Neoplasia- LAB
TJH
Module
Presentations
28
29
LEC2 Neoplasia-JJ

Lecturer: TJH: Dr. Hawke; DP: Dr. Predescu; MT:

-Submit Dr. Tarnopolsky; PM: Dr. Margetts; HF: Dr. Faraji;
modules
during JJ: Dr. Jansen;
class time
TUT2