Beruflich Dokumente
Kultur Dokumente
Intervention
Streptomycin Binds to 30S Intramusc Pregnancy, Giddiness, vertigo, • Draw blood
ribosomal sub ular hypersensitivity tinnitus, ataxia, for peak level
unit, inhibiting Tuberculo hypersensitivity 1 hour I.M
protein sis reactions, injection.
synthesis in Adult: 15 ototoxicity and • Monitor liver
bacterial cell, mg/kg nephrotoxicity. and kidney
which causes daily; max: Potentially Fatal: function
mis reading of 1 g daily. Anaphylactic shock, tests, watch
genetic cosd Reduce aplastic anaemia for evidence
and ultimately max daily and agranulocytosis. of
cell deathe. dose to Stevens-Johnson hepatotoxicit
500-750 syndrome and toxic y and
mg in epidermal nephrotoxicit
patients necrolysis. y
>40 yr. As • Monitor
part of an temp. stay
intermitten alert for
t therapy: fever and
25-30 other s/s of
mg/kg/day super
2-3 infection
times/wk; • Assess
max: 1.5 neurologic
g/dose. status and
Not >120 sensory
g over the function
course of carefully
treatment watch closely
should be for
given neurotoxixity
unless , seizures
there are • Monitor CBC,
no other watch for
treatment evidence of
options. blood
Child: 20– dyscrasias
40 mg/kg
(max: 1 g)
daily or
25–30
mg/kg
(max: 1.5
g) 2–3
times
wkly.
Elderly:
≥60 kg:
Dosage
reduction
is required.
Renal
impairme
nt:
Modificatio
n in dose
or dosing
interval
may be
required
Drug name: Action: Indication: Contra-indication: Adverse reaction: Nursing
intervention:
Tetracycline To inhibit To reduce the Pregnancy, Gastrointestina • Monitor for
bacterial protein development of hypersensitivity l: anorexia, s/s of super
synthesis at level drug-resistant epigastric infection
or 30S and 50S bacteria and distress, nausea, and
bacterial maintain the vomiting, hypersensi
ribosomes and to effectiveness of diarrhea, bulky tivity
loose stools,
alter cytoplasmic Sumycin ‘250’ reaction.
stomatitis, sore
membrane of and Sumycin throat, glossitis, • With long-
susceptible ‘500’ Tablets black hairy term use,
organisms. (Tetracycline tongue, monitor
Hydrochloride dysphagia, CBC, liver
Tablets) and hoarseness, function
other enterocolitis, and tests, and
inflammatory
antibacterial bone
lesions (with
drugs, Sum- ycin candidal growth
‘250’ and overgrowth) in • Assess
Sumycin ‘500’ the anogenital neurologic
Tablets region, including status,
(Tetracycline proctitis and stay alert
pruritus ani. Rare
Hydrochloride instances of fir benign
Tablets) should esophagitis and intra
be used only to esophageal cranial
treat or prevent ulceration have hypertensi
infections that been reported in on
are proven or patients receiving
particularly the
strongly
capsule and also
suspected to be the tablet forms
caused by of tetracyclines.
susceptible Most of the
bacteria. When patients were
culture and reported to have
susceptibility medication
immediately
information are
before going to
available, they bed. These
should be reactions have
considered in been caused by
selecting or both the oral and
modifying parenteral
administration of
antibacterial
tetracyclines but
therapy. In the are less frequent
absence of such after parenteral
data, local use.
epidemiology and Skin and Skin
susceptibility Structures:
patterns may maculopapular
contribute to the and
empiric selection erythematous
of therapy. rashes.
Exfoliative
dermatitis has
been reported
but is uncommon.
Onycholysis and
discoloration of
the nails have
been reported
rarely.
Photosensitivity
has occurred.
Renal Toxicity:
increases in BUN
have been
reported and are
apparently dose-
related.
Hepatic
Cholestasis: has
been reported
rarely, and is
usually
associated with
high dosage
levels of
tetracycline.
Hypersensitivit
y Reactions:
Anaphylaxis;
serum sickness-
like reactions, as
fever, rash, and
arthralgia;
urticaria,
angioneurotic
edema,
anaphylactoid
purpura,
pericarditis,
exacerbation of
systemic lupus
erythematosus.
Hematological:
Blood: anemia,
hemolytic
anemia,
thrombocytopeni
a,
thrombocytopeni
c purpura,
neutropenia and
eosinophilia have
been reported.
Miscellaneous:
Dizziness and
headache have
been reported.
When given over
prolonged
periods,
tetracyclines
have been
reported to
produce brown-
black microscopic
discoloration of
thyroid glands.
No abnormalities
of thyroid
function are
known to occur.
Bulging fontanels
in infants and
intracranial
hypertension in
adults have been
reported.
Drug name: Action Indication Contra-Indication Adverse Reaction Nursing
Intervention:
Vitamin k Phytonadione is Hypersensitivity Pregnancy:
used in the to vitamin K. Inadequate
prevention and Severe reactions, information exists
treatment of including as to whether
hypoprothrombin fatalities, have vitamin K may
emia caused by occurred during affect fertility in
vitamin K and immediately human males or
deficiency, oral after i.v. females or have a
anticoagulants, or phytonadione teratogenic
other factors injection even potential or other
which impair the when precautions adverse effect on
absorption or have been taken the fetus. Large
synthesis of to dilute the amounts of
vitamin K. phytonadione vitamin K in
Phytonadione is solution and to pregnancy,
also used in the avoid rapid however, can
prevention and infusion. These cause jaundice in
treatment of severe reactions, the newborn.
hemorrhagic which may occur
disease of the in patients
newborn. receiving
phytonadione for
Phytonadione the first time,
may have a role resemble
in restoring hypersensitivity
normal clotting or anaphylaxis,
time in patients including shock
with and cardiac or
hypoprothrombin respiratory arrest.
emia induced by Therefore, use of
salicylates, the i.v. route
sulfonamides, should be
quinidine, quinine restricted to
or broad- those situations
spectrum where other
antibiotics, when routes are not
interference with feasible and the
vitamin K activity serious risk
is clearly the involved is
cause. considered
justified.