Beruflich Dokumente
Kultur Dokumente
doi:10.1111/j.1365-2044.2009.06109.x
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ORIGINAL ARTICLE
We performed a randomised, double-blind study to evaluate the effect of the pre-emptive use of
minimal dose intravenous fentanyl (25 lg) on the incidence of cough caused by a larger bolus of
intravenous fentanyl. Six hundred patients were randomly assigned to one of three groups to
receive either 0.5 ml saline 0.9% 1 min before administration of fentanyl 150 lg (3 ml), or
pre-emptive fentanyl 25 lg (0.5 ml) 1 min before administration of fentanyl 125 lg or 150 lg.
The incidence of fentanyl-induced cough was significantly lower in both pre-emptive groups
(7 (3.5%) for 125 lg fentanyl and 15 (7.5%) for 150 lg fentanyl) than in the saline group
(37 (18.5%); p = 0.001). We conclude that pre-emptive use of fentanyl 25 lg, administered 1 min
before bolus injection of fentanyl (125 or 150 lg), can effectively suppress fentanyl-induced cough.
. ......................................................................................................
Methods
47.7 (13.8)
104 96
64.9 (8.3)
161.9 (8.0)
108 (54.0%)
92 (46.0%)
155 (77.5%)
45 (22.5%)
46.9 (14.5)
101 99
64.1 (9.0)
162.8 (8.8)
115 (57.5%)
85 (42.5%)
148 (74.0%)
52 (26.0%)
45.1 (13.1)
102 98
65.9 (9.0)
162.4 (8.2)
109 (54.5%)
91 (45.5%)
146 (73%)
54 (27%)
Incidence
of cough
Odds ratio
Saline + fentanyl
150 lg
(n = 200)
Fentanyl 25 lg +
125 lg
(n = 200)
Fentanyl 25 lg +
150 lg
(n = 200)
37 (18.5%)
7 (3.5%)*
15 (7.5%)
0.16 (0.070.37)
0.36 (0.190.68)
Saline + fentanyl
150 lg
(n = 200)
Fentanyl 25 lg +
125 lg
(n = 200)
Fentanyl 25 lg +
150 lg
(n = 200)
Mild
Moderate
Severe
19 (51.4)
11 (29.7)
7 (18.9)
6 (85.7)
1 (14.3)
0
7 (46.7)
8 (53.3)
0
Saline +
fentanyl
150 lg
(n = 200)
Fentanyl
25 lg +
125 lg
(n = 200)
Fentanyl
25 lg +
150 lg
(n = 200)
136.6
135.4
77.9
77.6
76.4
76.7
138.8
138.6
78.9
76.8
75.3
74.8
136.9
136.2
79.0
78.3
74.7
74.8
(19.1)
(19.2)
(11.2)
(11.3)
(14.6)
(14.8)
(20.1)
(21.0)
(11.8)
(11.5)
(13.8)
(14.4)
(20.1)
(20.5)
(10.9)
(11.3)
(14.8)
(14.9)
ns
ns
ns
ns
ns
ns
SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart
rate.
2009 The Authors
Journal compilation 2009 The Association of Anaesthetists of Great Britain and Ireland