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Table of Contents
A Compendium of Abstracts of Studies on extracts, homeopathy and high dilution published by
Prof. Anisur Rahman Khuda-Bukhsh et al .......................................................................................................... 1
A Compendium of Articles Published in International Journal of High Dilution Research from
2008 2014 ................................................................................................................................................................... 1
Studies to be Read........................................................................................................................................................ 2
Fundamental Research ............................................................................................................................... 2
Sulphur alters NFB-p300 cross-talk in favour of p53-p300 to induce apoptosis in non-small cell
lung carcinoma. .................................................................................................................................. 2
Gas nanobubbles and aqueous nanostructures: the crucial role of dynamization ....................... 2
Hormetic effects of extremely diluted solutions on gene expression ............................................ 3
Clinical Research ......................................................................................................................................... 3
Influence of adjunctive classical homeopathy on global health status and subjective wellbeing
in cancer patients - A pragmatic randomized controlled trial. ....................................................... 3
'Nosodes' are no substitute for vaccines. ......................................................................................... 4
Homeopathy in France in 2011-2012 according to reimbursements in the French national
health insurance database (SNIIRAM). ............................................................................................. 4
Safety and compliance of a complex homeopathic drug (Contramutan N Saft) in the treatment
of acute respiratory tract infections: A large observational (non-interventional) study in
children and adults focussing on homeopathy specific adverse reactions versus adverse drug
reactions. ............................................................................................................................................ 5
Towards improving the reporting quality of clinical case reports in complementary medicine:
assessing and illustrating the need for guideline development. .................................................... 5
Risk in homeopathy: Classification of adverse events and homeopathic aggravations A cross
sectional study among Norwegian homeopath patients ................................................................ 6
Patients' preference for integrating homeopathy (PPIH) within the standard therapy settings in
West Bengal, India: The part 1 (PPIH-1) study ................................................................................. 7
Review ......................................................................................................................................................... 8
Life stories, homeopathy and permanent education: construction of shared healthcare. .......... 8
Time to sensitize medical graduates to the Indian Systems of Medicine and Homeopathy ........ 8
Hormesis: umbrella mechanism only for agents present in the environment. ............................. 8
Hormesis: principles and applications .............................................................................................. 9
Historical foundations of hormesis ................................................................................................... 9
Hormesis within a mechanistic context ............................................................................................ 9
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by
him
and
his
team.
Dr. Bukhsh has devoted more than 35 years
in research and has been involved in various
research studies on extracts, homeopathy,
and high dilutions. Dr Khuda-Bukhsh also
proposed Gene Regulatory Hypothesis of
homeopathic remedies almost two decades
back. This compendium covers most of his
publication titles on fundamental and basic
research extracts, homeopathy, and high
dilutions till date. The compendium may be
downloaded
for
free
at
www.researchinhomeopathy.org/compendi
um-arkb. This compendium is a reference
work of pure hard work, dedication, and
insight.
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Studies to be Read
Abstracts of peer reviewed studies published during April June 2015
Fundamental Research
Int J Oncol. 2015 Jun 22.
Sulphur alters NFB-p300 cross-talk in
favour of p53-p300 to induce apoptosis
in non-small cell lung carcinoma.
Saha S, Bhattacharjee P, Guha D, Kajal K,
Khan P, Chakraborty S, Mukherjee S, Paul S,
Manchanda R, Khurana A, Nayak D,
Chakrabarty R, Sa G, Das T.
Abstract
Adverse side effects of chemotherapy
during cancer treatment have shifted
considerable focus towards therapies that
are not only targeted but are also devoid of
toxic side effects. We evaluated the
antitumorigenic activity of sulphur, and
delineated the molecular mechanisms
underlying sulphur-induced apoptosis in
non-small cell lung carcinoma (NSCLC) cells.
A search for the underlying mechanism
revealed that the choice between the two
cellular processes, NFBp65-mediated
survival and p53-mediated apoptosis, was
decided by the competition for a limited
pool of transcriptional coactivator protein
p300 in NSCLC cells. In contrast, sulphur
inhibited otherwise upregulated survival
signaling in NSCLC cells by perturbing the
nuclear translocation of p65NFB, its
association with p300 histone acetylase, and
subsequent transcription of Bcl-2. Under
such anti-survival condition, induction of
p53-p300
cross-talk
enhanced
the
transcriptional activity of p53 and intrinsic
mitochondrial death cascade. Overall, the
findings of this preclinical study clearly
delineated the molecular mechanism
underlying the apoptogenic effect of the
non-toxic homeopathic remedy, sulphur, in
NSCLC cells.
Homeopathy 2015;104(2):101-15
Gas
nanobubbles
and
aqueous
nanostructures: the crucial role of
dynamization
Jean-Louis Demangeata
Nanobubbles (NBs) have been a subject of
intensive research over the past decade.
Their peculiar characteristics, including
extremely
low
buoyancy,
longevity,
enhanced solubility of oxygen in water, zeta
potentials and burst during collapse, have
led to many applications in the industrial,
biological and medical fields. NBs may form
spontaneously from dissolved gas but the
process is greatly enhanced by gas
supersaturation and mechanical actions
such as dynamization. Therefore, the
formation of NBs during the preparation of
homeopathic dilutions under atmospheric
pressure cannot be ignored. I suggested in
2009 the involvement of NBs in nanometric
superstructures revealed in high dilutions
using
NMR
relaxation.
These
superstructures seemed to increase in size
with dilution, well into the ultramolecular
range (>12c).
I report here new experiments that confirm
the involvement of NBs and prove the
crucial role of dynamization to create
superstructures specific to the solute. A
second dynamization was shown to enhance
or regenerate these superstructures. I
postulate that superstructures result from a
nucleation process of NBs around the solute,
with shells of highly organized water (with
ions and silicates if any) which protect the
solute against out-diffusion and behave as
nucleation centres for further dilution steps.
#researchinhomeopathy
Clinical Research
Complement
Ther
Med.
2015
Jun;23(3):309-17.
Influence
of
adjunctive
classical
homeopathy on global health status and
subjective wellbeing in cancer patients A pragmatic randomized controlled trial.
Frass M, Friehs H, Thallinger C, Sohal NK,
Marosi C, Muchitsch I, Gaertner K, Gleiss A,
Schuster E, Oberbaum M.
Abstract
Objectives: The use of complementary and
alternative medicine has increased over the
past decade. The aim of this study was to
evaluate whether homeopathy influenced
global health status and subjective
wellbeing when used as an adjunct to
conventional cancer therapy.
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Abstract
Background: Case reports have had a
varying level of recognition as a source of
evidence throughout the history of
medicine. In recent years, there has been a
revival of interest in clinical case reports in
both conventional and complementary
medicine. There is a need to further
improve the reporting quality of clinical
case reports of different Complementary
and Alternative Medicine (CAM) therapies.
Objectives: To provide an overview of the
different objectives for clinical case reports,
identify those that are most relevant for
CAM, and to develop a conceptual
framework for purpose orientated clinical
case reporting guidelines for CAM therapies.
To practically illustrate the chosen
approach by developing a clinical case
reporting guideline for homeopathic cases.
Methods: The various objectives of clinical
case reports were described by Prof. Milos
Jenicek, and the potential relevance of these
objectives for CAM were discussed and
graded by a mixed panel of experts. A
conceptual framework for developing
clinical case reporting guidelines for CAM
treatments with specific objectives is
proposed. The aim is to integrate both
'generic' and 'CAM therapy specific' quality
items. This framework has been practically
applied to the development of a reporting
guideline for clinical case reports in
homoeopathy which will be reported in a
second article.
Results: An overview is given of the clinical
case reporting literature. The conceptual
framework for the development of purpose
orientated CAM clinical case reporting
guidelines is presented. This framework is
based on alignment with the recently
published 'generic' CARE guideline for
reporting of clinical case reports, whilst
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Abstract
There is lack of studies assessing the
preference of Indian patients for integration
of homeopathy into standard therapy
settings. The objectives of this study were to
examine the knowledge, attitudes, and
practice of homeopathy among Indian
patients already availing homeopathy
treatment and its integration into
mainstream healthcare.
A cross-sectional survey was conducted
among adult patients attending the outpatients
of
the
four
government
homeopathic hospitals in West Bengal,
India.
A
self-administered
24-items
questionnaire in local vernacular Bengali
was developed and administered to the
patients.
A total of 1352 patients' responses were
included in the current analysis. 40%
patients
thought
that
homeopathic
medicines can be used along with standard
therapy. 32.5% thought that homeopathic
medicines might cause side effects, while
only 13.3% believed that those might
interact with other medications. Patients'
knowledge ranged between 25.1 and 76.5%
regarding regulations of practicing and
safety of homeopathic medicine in India and
abroad; while positive attitude towards the
same ranged between 25.4 and 88.5%.
88.6% of the patients had favorable attitude
toward integrated services. 68.2% of the
patients used homeopathic medicines in any
acute or chronic illness for themselves and
76.6% for their children. Preference for
integrated services was significantly
associated with better knowledge (P =
0.002), positive attitudes toward safety and
regulations (P < 0.0001), and integration (P
< 0.0001), but not with the level of practice
(P = 0.515).
A favorable attitude toward integrating
homeopathy into conventional healthcare
settings was obtained among the patients
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Review
Cien Saude Colet. 2015 Jun;20(6):17951803.
Life stories, homeopathy and permanent
education: construction of shared
healthcare.
[Article in English, Portuguese]
Slomp Junior H1, Feuerwerker LC2, Merhy
EE3.
Abstract
Taking its inspiration from the homeopathic
method of collecting data, and acting in a
context of permanent education in health,
this study aimed to analyze the possibilities
that can be offered for healthcare by
construction of Life Histories, in organized
encounters for collective elaboration of
shared therapeutic projects. Some changes
that arose from the use of this strategy are
discussed: health workers and users
changed their stances in relation to each
other; teams looked at cases with a new
approach; and both these developments
appeared to have created stronger and
more effective encounters to produce care.
It is concluded that, in the ambit of this
study, Life Histories, by intensifying the
collective operation of soft technologies, in
an invitation to the shared therapeutic
project, increased the porosity of the teams,
and the recognition of the user as a valid
interlocutor.
The
conclusion
favors
reorientation of approach to the other
technological levels in health work, and
recognition of Life Histories as powerful
elements for production of effective
healthcare.
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Hormesis;
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Hormesis;
Homeopathy 2015;104(2):123-38
Enhancement of adaptive biological
effects by nanotechnology preparation
methods in homeopathic medicines
Iris R. Bell, Gary E. Schwartz
Multiple studies have demonstrated that
traditional homeopathic manufacturing
reagents and processes can generate
remedy source and silica nanoparticles
(NPs). Homeopathically-made NPs would
initiate adaptive changes in an organism as
a complex adaptive system (CAS) or
network. Adaptive changes would emerge
from
several
different
endogenous
amplification processes that respond to
exogenous danger or threat signals that
manufactured
nanomaterials
convey,
including (1) stochastic resonance (SR) in
sensory neural systems and (2) timedependent sensitization (TDS)/oscillation.
SR is nonlinear coherent amplification of a
weak signal by the superposition of a larger
magnitude white noise containing within it
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Conference Presentation
Informational paradigm, practice and basic research
Richard Blostin
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