2011-12 Faes Grad School Catalog

F A E S
G R A D U A T E
S C H O O L
A T
Fifty second year

20112012 Catalog of
Graduate and Undergraduate Courses
S H A R I N G K N O W L E D G E . C R EAT I N G O P P O RT U N I T Y.
N I H
Calendar for 2011-2012

SPRING SEMESTER
FALL SEMESTER
July 1-Aug. 23
Aug. 19
Aug. 23
Aug. 29 Sept. 7
Sept. 8 Oct. 8
Sept. 12
Sept. 23
Oct. 8
Oct. 10
Oct. 21
Nov. 10
Nov. 11
Nov. 24
Dec. 16
Dec. 30
Jan 4
Jan. 9 18
Jan. 19 Feb. 18
Jan. 24
Feb. 4
Feb. 18
Feb. 20
Mar. 2
April 13
May 11
Online registration
Last day for mail registration
Open House*
Walk-in Registration
Late Walk-in Registration ( ($10.00 late registration fee)
Classes begin
Last day of course transfer -without fee
Last day to register
Columbus Day No classes
Last day to withdraw and Transfer
Last day to change status (credit/audit or vice versa)**
Veterans Day - No classes
Thanksgiving DayNo classes
Close of Fall Semester***
Last day for mail registration

Open House
Walk-in Registration
Late Walk-in Registration ($10.00 late registration fee)
Classes begin
Last day of course transfer -without fee
Last day to register
Presidents DayNo classes
Last day to withdraw and Transfer
Last day to change status (credit/audit or vice versa)**
Close of Spring Semester***
The Registrars Office and Bookstore will be open 5-8 p.m. during the first week of classes, in addition to regular hours.
* PLEASE JOIN US FOR OUR OPEN HOUSE ON AUGUST 23, 2011 FROM 4:00PM-7:00PM AT THE SOCIAL AND ACADEMIC CENTER,
LOCATED AT 9101 OLD GEORGETOWN ROAD, BETHESDA. WALK-IN REGISTRATION WILL BE ACCEPTED.
** Please call Registrars office for deadline to change status or withdraw from courses that are not on the 14 or 16 week schedule.
*** Class meetings that are canceled for any reason will be made up.
Registration by Mail
Advance registration is possible by mail by completing and sending the attached form with tuition check or contract to FAES at NIH, 1 Cloister Court,
(Bldg. 60, Suite 230) until August 19.
Introducing Online Registration for FALL 2011 semester July 1 August 23, 2011. Students who have taken previous FAES courses (including BIOTRAC) will need to email Priyanka Basa at basap@mail.nih.gov to request a new password. New students can create an account at www.
faes.org and follow the online instructions on how to register between July 1st - August 23rd.
Online registrations paying with check, Purchase Order or Training Nomination form will not be completed until payment is received (mail or
walk-in) within five (5) business days. FAES Faculty and family members must register by mail or in person.
Do not send registration card without some form of payment.
Please note: Asking your institute to pay for training does not constitute registration. If you are registering by mail, you need to send the Training
NominationSF182 Form (signed) and a Registration Card (see deadline for mail registration). If you are registering in person, you need to bring the
Training NominationSF182 Form and a Registration Card (see dates for in-person registration).
If you are paying your tuition with a credit card, (Visa, MC or Discover) you may fax your registration to 301-402-0174 up until August 19.
Please note: SF182 forms are available from your Administrative Officer.
Registration in Person
Registration in person will be held in Bldg. 60, Suite 230 in accordance with the dates below.
FALL
SPRING
10 a.m. 4 p.m. August 29, 30, 31, Sept. 1, 2, 6, 7

5 7 p.m. Tuesday, September 6
10 a.m. 4 p.m. Jan. 9, 10, 11, 12, 13, 17, 18

5 7 p.m. Tuesday, Jan. 17
Catalog Information
Catalogs may be obtained free of charge in the FAES Offices (Bookstore Bldg. 10, Room B1-L-101, Business Office Bldg. 10, Rm. B1-C-18, or
Administrative Office Bldg. 60, Suite 230) or visit our website at www.faes.org
For Further Information
FAES Graduate School 301-496-7976
Business Office 301-496-8064
Bookstore 301-496-5272.
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
FAES
Graduate and Undergraduate

Courses at NIH
Catalog
2011-2012
Dean
Constance Tom Noguchi, Ph.D.
Registrar
Audrey L. Lyons
FOUNDATION FOR ADVANCED EDUCATION

IN THE SCIENCES, INC.
Postal Address:
One Cloister Court, Suite 230
Bethesda, Maryland 20814-1460
Inter-Office Address:
Building 60
Suite 230
FAES Board of Directors

President ....................................................................................................................................................................................... Earl Laurence, M.B.A.
First Vice President ..................................................................................................................................................................... Kathleen Clouse, Ph.D.
Second Vice President .................................................................................................................................................................. Warren Leonard, M.D.
Treasurer ......................................................................................................................................................................................... Shelby Berger, Ph.D.
Secretary ......................................................................................................................................................................................... Carol J. Thiele, Ph.D.
Ann Ashby, M.B.A.

Barbara A. Baird, Ph.D.
Sherri Bale, Ph.D.
Michael A. Beaven, Ph.D.
Edwin D. Becker
Steven J. Berkowitz, CPA, MBA
Mark R. Cookson, Ph.D.
William R. Galey, Ph.D.
Angela Gronenborn, Ph.D.
John Hanover, Ph.D.
Deborah M. Hinton, Ph.D.
Caroline Jochems, M.D., Ph.D.
Electron Kebebew, M.D.
Jeffrey B. Kopp, M.D.
Larry Laughlin, M.D., Ph.D.
Susan Leitman, M.D.
Derek LeRoith, M.D., Ph.D.

Sharon Milgram, Ph.D. (Liaison)
Constance T. Noguchi, Ph.D.
Harvey B. Pollard, M.D., Ph.D.
Paul Plotz, M.D.
Jeffrey V. Ravetch, M.D., Ph.D.
Tracey Rouault, M.D.
Lawrence E. Samelson, M.D.
Paul Schwobel, CPA
Edward Tabor, M.D.
Simeon Taylor, M.D.
Robert Temple, M.D.
Maria L. Turner, M.D.
Richard G. Wyatt, M.D. (Liaison)
Marian Young, Ph.D.
Ex-Officio Member
Administrative Staff
Alexis Alleyne, B.A ...........................................................................................................................................................Insurance Program/HR Manager
Nancy Avent .................................................................................................................................................................................... Insurance Supervisor
Priyanka Basa, B.S...............................................................................................................................................................Communications Coordinator
Shawna Clay, A.A ................................................................................................................................................................................ Insurance Assistant
Carline Coote, B.S .............................................................................................................................................................................Conference Manager
Shawn Foreman ....................................................................................................................................................................................... Staff Accountant
Jaleh Gormley, B.A ................................................................................................................................................................................... Staff Accountant
Audrey Lyons ........................................................................................................................................................................................................Registrar
Manny Mekonnen, B.S ........................................................................................................................................................................Bookstore Assistant
Rose McNeeley, B.S. ....................................................................................................................................................................................SAC Manager
Darlissa Musgrove ...............................................................................................................................................................................Bookstore Assistant
Elizabeth Perkins, B.A ......................................................................................................................................................................... Bookstore Manager
Marie Perng, B.A., CPA ......................................................................................................................................................................... Senior Accountant
Jennifer Schultze, B.S.......................................................................................................................................................................... Insurance Assistant
Paul Schwobel, CPA ............................................................................................................................................................................................Controller
Beatrice Sonnenberg ............................................................................................................................................................................ Assistant Registrar
Danita Waker, MPH ..................................................................................................................................................................... Administrative Assistant
Melissa Zhong, B.A. ............................................................................................................................................................................ Insurance Assistant
This is the catalog for the 2011-2012 Academic Year. A schedule giving only the day and hour for Spring 2012 courses will be published.
Please retain this catalog for all other information; copies are limited in number.
ii
Table of Contents
Fall 2011 Semester Schedule ........................................................................................................................................................................................1
Regulations and Procedures .........................................................................................................................................................................................3
Lists of Board Review Courses ...................................................................................................................................................................................38
Biochemistry and Biophysics .......................................................................................................................................................................................6
BIOC 301
Biochemistry I
BIOC 302
Biochemistry II
BIOC 315
Protein Biochemistry
BIOC 316
Structure and Function of Biological Macromolecules
BIOC 433
Current Methodology in Nucleic Acid Structure and Function Research
BIOC 505
Cell Membrane and Intracellular Trafficking
BIOC 527
Biochemistry and Metabolism of Lipids
BIOC 533
The Molecular and Cellular Basis of Intercellular Communication
BIOC 539
Recent Discoveries in Molecular Biology
Bioinformatics ................................................................................................................................................................................................................ 8
BIOF 309
Introduction to Python
BIOF 312
Introduction to Perl
BIOF 411
Introduction to Genomics
BIOF 429
Practical Bioinformatics
BIOF 502
Medical Genomics for Clinicians and Researchers
BIOF 518
Theoretical and Applied Bioinformatics
BIOF 537
Computational Biology
BIOF 538
Biological Database Design
BIOF 552
Biology and Genetics ..................................................................................................................................................................................................10
BIOL 101
Introductory Biology
BIOL 102
Introductory Biology-Genetics
BIOL 262
Molecular Approaches to Studying Diseases
BIOL 317
Molecular Cell Biology
BIOL 319
Stem Cells and Their Niches
BIOL 325
Basic Human Neuroanatomy
BIOL 327
Modern Developmental Biology
BIOL 338
Epigenetics and Medical Disorders
BIOL 435
Current Trends in the Neurobiology of Mental Illness
BIOL 504
Developmental and Synaptic Neuroplasticity
GENE 415
Control of Gene Expression
GENE 500
Introduction to Medical Genetics
GENE 505
Embryology, Developmental Biology and Human Malformations
GENE 510
Genetic Counseling: Professional Topics Seminar
GENE 514
Current Concepts in Clinical Molecular Genetics and Molecular Diagnostics
GENE 644
A Review of Medical Genetics
Biotechnology (BIO-TRAC) ..........................................................................................................................................................................................14
TRAC 1
Biotechnology Techniques
TRAC 2
Recombinant DNA Methodology I
TRAC 3
Recombinant DNA Methodology II
TRAC 4
Cellular Immunology: Principles and Methods
TRAC 5
Separation Techniques
TRAC 6
Cellular and Molecular Basis for Understanding, Diagnosis and Therapy of Cancer
TRAC 7
Animal and Human Cell Culture: Methods and Applications
TRAC 8
Immunochemistry and Monoclonal Antibody Production
TRAC 9
Polymerase Chain Reaction and Molecular Hybridization Technology
TRAC 10
Protein DNA Interactions: Gene Specific and Epigenetic Regulation of Expression of the Mammalian Genome
TRAC 11
Genome Analysis
TRAC 12
Transgenic Technology: Methods and Application
iii
TRAC 15
TRAC 16
TRAC 18
TRAC 19
TRAC 20
TRAC 21
TRAC 22
TRAC 23
TRAC 24
TRAC 25
TRAC 26
TRAC 28
TRAC 29
TRAC 30
TRAC 31
TRAC 32
TRAC 33
TRAC 34
TRAC 35
TRAC 36
TRAC 37
TRAC 38
TRAC 39
TRAC 40
TRAC 41
TRAC 42
TRAC 43
Two Hybrid Selection: Identification and Characterization of ProteinProtein Interactions

Expression, Detection & Purification of Recombinant Proteins in Prokaryotic & Eukaryotic Cells
Stem Cells
Mutation Detection and Analysis: Molecular Approaches
Immunocytochemistry
Mitochondrial Molecular Biology and Pathology Workshop
Hybridization Techniques: Labeling, Detection and Applications
Flow Cytometry: Principles and Methods
DNA Microarrays: Principles and Applications of DNA Microarrays
Proteomics: Principles and Methods
PCR Methodology: Principles, Optimization and Applications
Angiogenesis: Analytical Techniques for the Quantitation of Angiogenesis and Lymphoangiogenesis
Laser Capture Microdissection (LCM): Methods for Microgenomic Analysis
Small Interfering RNA (siRNA) and Functional Genomics
Vaccines: Development and Evaluation of Efficacy
Nanotechnology in Medicine
Clinical Proteomics and Biomarker Discovery
Advanced Microarray Analysis and Pathway Integration
Immunofluorescence and Confocal Microscopy
Cell Line Identification and Authentication
Real Time and Quantitative PCR
Digital Imaging in Microscopy
Epigenetics
Protein Informatics
miRNA: Tools and Technologies for the Quantitative and Functional Analysis in Mammalian Cells
Junior Scientist Training Program
Ips Cells: Principles and Methods
Chemistry, Physics and Imaging ................................................................................................................................................................................ 24

CHEM 101
General Chemistry I
CHEM 102
General Chemistry II
CHEM 211
Organic Chemistry I
CHEM 212
Organic Chemistry II
CHEM 220
Physical Chemistry with Applications to the Biological Sciences
CHEM 244
Practical NMR Spectroscopy: Basic Methods for Characterizing Molecules
CHEM 327
The Art of Drug Design and Discovery
CHEM 341
Advances in Synthetic Organic Chemistry I
CHEM 342
Advances in Synthetic Organic Chemistry II
IMAG 409
Principles and Applications of Magnetic Resonance Imaging (MRI) in Biomedicine
PHYS 201
Introductory Physics I
PHYS 202
Introductory Physics II
PHYS 245
Topics in Modern Physics-Relativity, Quantum Mechanics and Cosmology
Education and General Studies ..................................................................................................................................................................................26
GENL 161
Art Songs: Chamber Music with Words Lecture and LIVE performances
GENL 163
Qi Gung and Tai Chi with a Brief Review of Chinese Martial Arts
GENL 319
MCAT- Review
GENL 322
GRE-Review
GENL 511
Boot Camp for University Teaching
Immunology and Microbiology ...................................................................................................................................................................................27
IMMU 403
Basic Principles of Immunology and Hypersensitivity
IMMU 419
Vaccines 2012
IMMU 504
Allergy and Clinical Immunology
IMMU 521
Molecular and Cellular Mechanisms of Immunity I
IMMU 522
Molecular and Cellular Mechanisms of Immunity II
MICR 211
Introductory and General Microbiology
MICR 317
Introduction to Molecular Virology
MICR 418
Emerging Infectious Diseases
M ICR 432
Human Virology
MICR 527
Introduction to HIV/AIDS Research
iv
Languages..................................................................................................................................................................................................................... 29
CHIN 101
Introduction to Chinese
CHIN 102
Intermediate Chinese
CHIN 301
Practical Chinese I
CHIN 302
Practical Chinese II
CHIN 401
Chinese Literature I
CHIN 402
Chinese Literature II
ENGL 105
Fundamental English Conversation I
ENGL 108
Fundamental English Conversation II
ENGL 205
Intermediate English I
ENGL 207
Intermediate English II
ENGL 302
Advanced English Conversation I
ENGL 304
Advanced English Conversation II
ENGL 305
Advanced English Structure I
ENGL 306
Advanced English Structure II
FRCH 101
French for Beginners I
FRCH 102
French for Beginners II
FRCH 201
Intermediate French I
ITAL 101
Italian for Beginners I
ITAL 102
Italian for Beginners II
JAPN 101
Introduction to Japanese I
JAPN 102
Introduction to Japanese II
JAPN 203
Intermediate Japanese I
JAPN 204
Intermediate Japanese II
JAPN 305
Advanced Japanese I
JAPN 306
Advanced Japanese II
JAPN 407
Advanced Japanese III
JAPN 408
Advanced Japanese IV
SPAN 101
Spanish for Beginners I
SPAN 102
Spanish for Beginners II
SPAN 203
Intermediate Spanish I
SPAN 204
Intermediate Spanish II
SPAN 208
Spanish for Healthcare Providers
Mathematics, Epidemiology & Statistics .................................................................................................................................................................. 33
MATH 127
Elementary Calculus I
MATH 128
Elementary Calculus II
STAT 200
Introduction to Experimental Statistics
STAT 317
Introduction to Epidemiology
STAT 318
Statistical Methods in Epidemiology
STAT 321
Methodology in Clinical Trials
STAT 322
Intermediate Epidemiology
STAT 435
Genetic Epidemiology
STAT 500
Statistics for Biomedical Scientists
STAT 518
Categorical Data Analysis
STAT 525
Nonparametric and Robust Methods
STAT 529
Survival Data Analysis
Medicine and Physiology.............................................................................................................................................................................................35
MEDI 211
Introduction to the Principles of Endocrinology
MEDI 217
Human Physiology I: Neural, Cardiovascular, Pulmonary, Sensory, and Neonatal Systems
MEDI 302
Introduction to Chinese Acupunctology
MEDI 303
Regenerative Medicine: Considering Applications and Treatments
MEDI 316
Biology of Cancer
MEDI 326
Introduction to Global Health
MEDI 329
Advanced Topics in Cancer: Tumor Microenvironment and Metastasis
MEDI 507
Inborn Errors of Metabolism
MEDI 522
Neural Immune Interactions in Health and Disease
MEDI 550
Introduction to the Principles of Clinical Research
MEDI 552
Demystifying Medicine for Ph.D. Students, Fellows and Staff
Medical Subspecialty Review Courses.......................................................................................................................................................................37
MEDI 723
A Review of Endocrinology: Diagnosis and Treatment
MEDI 725
Psychopharmacology and Neuroscience Course: Update 2011
Pharmacology and Toxicology .................................................................................................................................................................................... 39

PHAR 359
Pharmacology of Chinese Herbs
PHAR 400
Pharmacology
PHAR 500
Principles of Clinical Pharmacology I & II
PHAR 511
Current Concepts in Pharmacology and Therapeutics
TOXI 303
Introductory Toxicology
TOXI 504
Toxicology Principles and Practice
Public Health Certificate Program .............................................................................................................................................................................. 41
PBHL 501
Environmental Health
PBHL 507
Communicating Science for the Lay Audiences
PBHL 511
Introduction to Applied Public Health Nutrition
PBHL 512
Social and Behavioral Sciences
PBHL 517
Health Policy Management
PBHL 519
Health Disparities
PBHL 5xx
Public Health in Historical Perspective
PBHL 5xx
Ethics in Public Health
PBHL 602
Complexity, Flexibility and Systems Thinking
PBHL 607
Capstone Project in Public Health
Technology Transfer Certificate Program ................................................................................................................................................................... 46
TECH 501
Inside and Outside the FDA
TECH 503
Business Law Primer for Life Science Entrepreneurs
TECH 504
FDA Regulation, Industry, and Hidden Intellectual Property
TECH 506
Researcher Commercialization Webinar Course: The Essentials
TECH 512
Global Bioethics for Scientists and Administrators
TECH 513
Introduction to Technology Transfer
TECH 521
Tools for Technology Transfer
TECH 565
Biomedical Business Development for Scientists
TECH 566
Biotechnology Business Leadership and Management
TECH 567
International Strategic Partnering and Business Development
TECH 572
Marketing Strategies for Scientific Organizations
TECH 575
Business Finance and Accounting Principles for Scientists Introduction
TECH 576
Topics in Business Management for Scientists
TECH 579
Negotiation Workshop
TECH 582
Intellectual Property and Patent Prosecution for Scientists
TECH 584
Medical Product Development
TECH 586
International Science Technology and Innovation Policy
TECH 587
Planning for Life Science Companies: Transformational Growth and Implications- Organization, Process and Technology
TECH 592
Public-Private Partnerships
TECH 607
Capstone Course in Technology Transfer
Faculty Biographies and Telephone Numbers ........................................................................................................................................................... 53
Map of NIH .................................................................................................................................................................................................................... 59
Mail Registration Form............................................................................................................................................................................................ Insert
NOTES:
In the case of a full year course, registration may be made for the entire year or for each semester separately. Failure to reregister for the
second semester could result in cancellation of that semester due to lack of enrollment.
Classes are not held on days when government offices are closed early or all day due to hazardous weather conditions, or when evening weather
conditions are predicted to worsen. If in doubt, contact the school office (301-496-7976) or the instructor.
Biotechnology (TRAC) courses do not follow semester schedules. For exact dates, refer to course descriptions.
vi
vii
viii
Fall 2011 Semester Schedule

MONDAY
Course
BIOC 301
BIOF 309
BIOL 338
CHEM 211
CHIN 101
ENGL 105
ENGL 302
GENL 322
IMAG 409
MATH 127
MEDI 302
MICR 211
MICR 317
STAT 200
STAT 529
TECH 521
TOXI 303
Title
Instructor
Time
Tuition
Introductory Biochemistry I
Introduction to Python (7 weeks Sept. 26 Nov. 7)
Epigenetics and Medical Disorders (7 weeks Oct. 17-Dec.16)
Organic Chemistry I (Wed. required)
Fundamental English I
GRE Review (7 weeks)
Principles and Applications of Magnetic
Resonance Imaging (MRI) in Biomedicine
Elementary Calculus
Introduction to Experimental Statistics I
(Class will be held at Executive Boulevard)*
Ho
Cherry
Gebert
Freedberg
Lum
Miller
Miller
Ou
Komlosh
5:30-8:40
5:30-7:40
5:30-7:40
5:30-7:00
5:30-8:40
4:15-7:10
7:10-10:05
5:30-7:40
5:30-7:40
$435
145
145
435
435
435
435
145
290
Momenan
Wu
Tang
Arya
Ghebregiorgis
Hung
Goldstein
5:30-8:40
5:30-8:40
5:30-8:40
5:30-7:40
5:30-8:40
5:30-8:40
5:30-7:40
435
435
435
290
435
435
290
Mitkus
5:30-7:40
290
Title
Instructor
Time
Basic Human Neuroanatomy (Thur. Required)
Current Trends in the Neurobiology of Mental Illness
General Chemistry I
Advances in Synthetic Organic Chemistry I
Practical Chinese
Introduction to Medical Genetics I
Art Songs: Chamber Music with Words
Basic Principles of Immunology and
Hypersensitivity (also offered Wed.)
Communicating Science to Lay Audiences
Statistics for Biomedical Scientists I
International Strategic Partnering and Business Development
Business Finance and Accounting Principles
for Scientists Introduction (Class will be held at Executive Boulevard)
Malone
Herkenham
Zarate
Metaferia
Appella
Lum
Miller
Jorgenson
Miller
King
Banu
Hart
Epstein/Krash
Finerty
5:30-840
5:30-7:00
5:30-8:40
5:30-8:40
5:30-7:40
5:30-8:40
7:10-10:05
5:30-8:40
4:15-7:10
5:30-8:40
5:30-8:40
5:30-7:40
7:00-9:00
5:30-7:40
$435
435
435
435
290
435
435
435
435
435
435
290
290
290
Kwon/Nelson
Eresian
Patel
Rosenberg
Shah
Khanna
5:30-7:40
5:30-8:40
5:30-8:40
5:30-8:40
5:30-8:40
5:30-7:40
290
435
435
435
435
290
Reichman
5:30-7:40
290
Ferguson//Provorny 5:30-8:40
435
TUESDAY
Course
BIOF 411
BIOL 325
BIOL 435
CHEM 101
CHEM 341
CHIN 301
ENGL 105T
ENGL 205
ENGL 302T
FRCH 101
FRCH 201
GENE 500
GENL 161
IMMU 403T
PBHL 507
PHYS 201
STAT 317
STAT 321
STAT 500
TECH 567
TECH 575
TECH 607
Tuition
WEDNESDAY
Course
BIOC 527
BIOF 429
CHEM 211
CHEM 220
CHIN 401
ENGL 305
GENE 505
GENL 163
IMMU 403W
MEDI 303
MEDI 329
PBHL 517
PHYS 245
SPAN 101
TECH 503
Title
Instructor
Time
Tuition
Biochemistry and Metabolism of Lipids

Practical Bioinformatics (10 weeks)
Organic Chemistry I (Mon. required)
Physical Chemistry with Applications to the Biological Sciences
Embryology, Developmental Biology and Human Malformations
Qi Gung and Tai Chi with a Brief Review of Chinese
Martial Arts (7 weeks)
Basic Principles of Immunology and
Hypersensitivity (also offered Tues.)
Regenerative Medicine: Considering
Applications and Treatment
Advanced Topics in Cancer: Tumor Microenvironment
And Metastasis
Health Policy and Management
Topics in Modern Physics Relativity, Quantum Mechanics
and Cosmology (7 weeks)
Business Law Primer for Life Science Entrepreneurs
Francis
Bhagwat
Freedberg
Nyden
Lum
Miller
Biesecker
Momenan
5:30-8:40
5:00-8:00
5:30-7:00
5:30-7:40
5:30-8:40
4:15-7:10
5:30-6:30
5:30-7:30
$435
290
435
290
435
435
145
145
Finerty
5:30-7:40
290
Hunsberger
5:30-7:40
290
Rittler/
Shuman Moss
Hafner-Eaton
Eresian
5:30-7:30
290
5:30-8:40
5:30-7:40
435
145
Rodriguez
Provorny/Vepa
5:30-7:40
5:30-7:40
290
290
Title
Instructor
Time
Molecular Cell Biology
Basic Human Neuroanatomy (Tues. required)
Molecular and Cellular Mechanisms of Immunity I
Italian for Beginners
Introduction to the Principles of Endocrinology
Human Physiology I: Neural, Cardiovascular, Pulmonary,
Sensory & Neonatal Systems
Introduction to Applied Public Health Nutrition
Strategies to Improve Population Health
Principles of Clinical Pharmacology I (Sept. 1 Dec 15)
Biomedical Business Development for
Scientists (Class will be held at Executive Boulevard)*
Busby
Espey
Herkenham
Henkart
Tecuta
Moorman
Celi
Sinnarajah
5:30-8:50
5:30-7:50
5:30-7:00
5:30-7:50
5:30-8:50
5:30-8:50
5:30-7:50
5:30-7:50
$435
290
435
290
435
435
290
290
McDowell
5:30-7:50
290
Lertora
Roman
Major
Ferguson/Salagaller
6:30-7:45
5:30-8:50
5:30-8:50
5:30-7:50
290
435
435
290
Muroff
Smith
5:30-7:50
5:30-7:50
290
290
Title
Instructor
Time
Genetic Counseling: Professional Topics Seminar

Planning for Life Science Companies: Transformational
Growth and Implications Organization, Process and Technology
Biesecker/Madeo
Truman
2:30-5:30
2:00-4:00
THURSDAY
Course
BIOF 537
BIOL 317
BIOL 325
IMMU 521
ITAL 101
JAPN 101
MEDI 211
MEDI 217
PBHL 511
PHAR 500
SPAN 203
STAT 435
TECH 565
TECH 579
TECH 584
Tuition
FRIDAY
Course
GENE 510
TECH 587
Tuition
$580
290
Please note: During the semester, a number of Monday and Thursday classes are not held because of Federal holidays. Monday and Thursday
class times have been adjusted accordingly.
* Please note: Students attending classes at Executive Boulevard will be responsible for paying parking fees directly to the attendant.
The Foundation for Advanced Education in the Sciences is organized to foster scientific research and education by facilitating communication among scientists and by sponsoring formal instruction in the sciences. It was founded by scientists who believe learning,
research and teaching are mutually reinforcing processes essential to the evolution of science; that research receives a powerful impetus from the activities and enterprise of scientists who combine and interchange roles as student, investigator and teacher; and that
throughout the search for truth, education must be a continuing, central theme.
Sponsorship and management of The FAES Graduate School at NIH represent one aspect of the Foundations educational activities. We
are especially grateful to the outstanding scientists and teachers who have taught and continue to teach these courses.
Regulations and Procedures

Admission
Courses are open to all qualified persons, both government and nongovernment. The FAES does not discriminate on the basis of race, color,
religion, sex, age, handicap, national or ethnic origin or veteran status, in
administration of its educational policies, admissions policies, scholarship
programs, and other educational programs.
Entrance Requirements
Entrance requirements differ with the level of the course for which the
student is registering. Undergraduate courses, in general, are open to
persons who are graduates of high school or equivalent, or who qualify
for the course because of satisfactory work experience. For admission
to more advanced courses, college work in the same or related field is
specified or understood. For some courses, definite prerequisites may
be stated. Registration for the second half of a year course requires
completion of the first semester or permission of the instructor.
When consent of the instructor is given as a necessary prerequisite
for a course, the instructor must be consulted before registration.
Any student who does not have a clear financial record with FAES will
not be permitted to register.
Accreditation
The FAES Programs operate with the approval of the Maryland Higher
Education Commission.
Transfer of Credit
(see Certificate in Technology Transfer Program)
FAES courses do not currently lead to degrees.
A student should not assume that credit for work done in FAES courses
at NIH will be granted by any particular college or university, although
such credit is generally given. The student who wishes to work for an
undergraduate or higher degree should consult in advance the dean or
departmental chairman of the institution from which he expects to receive
the degree, and receive approval for any courses in the FAES Programs
at NIH that he plans to use toward his degree.
Courses in the FAES Programs at NIH do not include laboratory work
unless this activity is stated specifically in the course description.
The Office of Personnel Management accepts certain course work in
these programs for examination and qualification purposes, on the same
basis as that from full-time colleges and universities.
The Master of Public Health Program at The George Washington
University recognizes certain courses within the FAES as substitutes for
those offered in the MPH Program. Successful completion of those FAES
courses allow students to apply for transfer of credit in the MPH Program.
For further information about the MPH Program and currently eligible
FAES courses, contact the Program office at 202-994-2807.
Certificate in Technology Transfer Program

FAES offers a Certificate in Technology Transfer Program that may be
completed in approximately 2 years by taking a sequence of courses and
a final independent project, totaling 15 credit units. This program is open

to anyone with a degree in science or engineering.
Transferring Certificate in Technology Transfer

Courses toward Degrees
Students who complete the Certificate in Technology Transfer Program at
FAES can now transfer all 15 credits as a block to University of Maryland
University Colleges (UMUC) Graduate School of Management and
Technology. By completing only 21 more credits at UMUC, students can
be awarded M.S. degrees (with a specialization in Technology Transfer) in
one of the following areas:
Management The M.S. in Management is designed for students
who are interested or have a background in a broad view of
management and who may have little or no technical experience.
Technology Management The M.S. in Technology Management
is designed for students who are interested in or have a background
in working and managing in technology-based organizations.
Information Technology The M.S. in Information Technology is
designed for students who are interested or have a background in
information technology.
Biotechnology Studies The M.S. in Biotechnology is designed
for students who are interested in learning about the science and
ethics of biotechnology and the development and management of
biotech businesses.
Upon completion of the M.S. degree from UMUC students can also earn
the Master of Business Administration (MBA) degree by completing an
additional 18 credits.
For further information please visit our website at www.faes.org.
Public Health Certificate Program

FAES has in development a Public Health Certificate Program that will
give professionals an overview of the five core disciplines of public health,
the core disciplines are epidemiology, biostatistics, environmental health
sciences, health policy and management, and social and behavioral
sciences. For further information on this program, please contact Dr.
Stephen Marcus at marcusst@mail.nih.gov
Registration
The registration period is shown on the school calendar on the inside
front cover. Registration is not complete until the required fees have been
paid. Registration for full year courses may be made for the entire year or
for each semester separately; failure to reregister for the second semester
could result in cancellation of that semester due to lack of enrollment.
Courses that are not on the 14 or 16 week semester schedule may
have a different registration period.
Regulations and Procedures continued

Federal Training Legislation
The Foundation for Advanced Education in the Sciences, Inc. is a
nonfederal facility, within the definition of the Government Employees
Training Act. Students should make arrangements with their training
offices well in advance of registration week. Both the Authorization
Form and our Registration Form must be submitted before registration
is completed.
Financial Assistance
The Gerald D. Aurbach Memorial Scholarship Fund (Guest
Researchers)/FAES Student Scholarship Fund (Postbacs and Graudate
Students) provides a limited number of full or partial scholarships for
students at the NIH with restricted income. The deadline for applications
is the same as that for mail registration. Students interested in further
information should call 301-496-7976. The Pierre Renault Memorial
Scholarship Fund (sponsored by R/M Nardone Associates Inc.) provides
financial aid for qualified Biotechnology students.
Course Load
Students employed full-time may carry more than two courses only
with the permission of the Registrar.
Fees
Tuition is $145.00 per credit (except for certain courses, e.g.
biotechnology courses and 600 level courses. See schedule of classes
for specific tuition charges). Students 65 years and over are eligible for
50% reduced tuition (for evening classes only).
Late Registration Fees: $10.00 late fee through the 4th week of the
term. Registration is not possible after the 4th week. See calendar for
dates.
Late Transfer Fee: There is a $3.00 late transfer fee for each course.
See calendar for dates.
Withdrawal Fee: See paragraph on Withdrawals and Refunds.
Change from Credit or Audit: A student may request from the Registrar
that his status in a course be changed from credit to audit, or vice versa,
provided the request is submitted in writing and is accompanied by the
$3.00 fee, no later than the end of the ninth week of the fall semester
(see Calendar) and no later than the twelfth week of the semester
Spring Semester*. Reporting a credit-audit change to the instructor
does not constitute an official change. Students not paying their own
fees must submit written approval from their Administrative Offices
when requesting a change. Grades: At the close of the semester,
students taking courses for credit will receive written notice by mail of
grades received. Upon request of the student or sponsor, grades will be
forwarded to Personnel or University office. The following grades are used:
AExcellent
BGood
CAverage
DPassable
FFailure
I**Incomplete
AUDAuditor
**The symbol I indicates that the required course work has not been
completed, and may be changed to another grade if the student provides
the instructor with a satisfactory explanation, and arranges to complete
the work within a reasonable time.
Transcript of Credit
Students may obtain official transcripts for their Personnel files or for
other purposes by requesting them in writing from the Registrar, with the
payment of $5.00 per copy. No transcripts are issued during registration.
Withdrawals and Refunds

Application for withdrawal from any course in the FAES Programs at
NIH must be made in writing to the Registrar. A form for this purpose is
available. To report the dropping of a course to an Instructor does not
constitute an official withdrawal. Permission to withdraw will not be given
to a student who does not have a clear financial record.
Refund of tuition fees will be granted only in cases of official withdrawal
according to the following schedule (based on calendar weeks):
Change of Status Fee: There is a $3.00 fee for a change from credit
to audit or vice versa.
From the time of registration through the second week of term: tuition
less $20.00 per course.
Transcript Fee: A fee of $5.00 per transcript will be charged for the
first 10 copies. Additional transcripts will be charged at $3.00 per copy,
whenever multiple transcripts are requested at one time. A students
record will be supplied on the regular Foundation form. Fee must
accompany request.
During third and fourth weeks of term: 60% of total tuition will be
refunded.
Returned Check Fee: There will be a $25.00 fee for checks returned
from the bank for any reason.
Please note: Late fees are NOT refundable.

Students who did not pay their own tuition will be responsible for paying
the prorated portion of their tuition. For more information call the office of
the Registrar.
These are current fees and are subject to change.
Attendance at Classes
A student may not attend classes until registration has been
completed and fees due are paid. The student is expected to attend all
class sessions, and even unavoidable absences do not relieve him/her
from responsibility for work assigned during his/her absence.
Credit and Grades

Credit: Persons having registered for credit must complete all of the
course work as required by the instructor.
Audit: An auditor must pay the same tuition and meet the same
prerequisites as a credit student. He receives full privileges of class
participation, if he chooses to exercise them. An auditor does not receive
a grade; he receives only a mark of AUD.
During fifth and sixth weeks of term: 40% of total tuition will be refunded.
After the sixth week: no refund, and withdrawal is not possible.
Refunds will be computed as of the date the application for withdrawal

is received in the office. In no case will tuition be reduced or refunded
because of non-attendance at classes, or because of failure to consult
with the instructor, in advance of registration, when so indicated in course
description.
Because commitments for instruction and other arrangements are
necessarily made at the beginning of the semester, no refunds for any
reason can be made except in accordance with the above schedule.
The Foundation reserves the right to limit registration, cancel, terminate
or postpone courses, or to combine classes; to change instructors; to
make any changes deemed advisable in registration and in fees; and to
require the withdrawal of any student at any time for such reasons as the
Foundation deems sufficient.
Courses of Instruction
Courses sponsored by FAES as a part of its regularly established
curriculum are listed for 2011-2012 in the following pages by departments
of instruction.
The words Fall and Spring show the semester in which the course
is offered. ***The word Year indicates that the course is a two-semester
course. The number of credits shows the value of the course in semester
hours. One credit corresponds to 16 standard contact hours.
Courses numbered from 1 to 99 are intended for general adult
education and may not be of college level.
Courses numbered from 100 to 199 are offered at lower college level
(Freshman/Sophomore).
Courses numbered from 200 to 299 are intended for upper college
level, requiring at least one college level prerequisite (Junior/Senior).
4. Visiting Scientist AssistanceThere are at the NIH a large number

of Visiting Fellows, Guest Researchers and Special Volunteers, who
are ineligible for Federal health insurance plans available to Federal
Employees. To fill this gap, the FAES offers a health insurance plan
which is open to persons who work for or at NIH in full-time positions.
FAES also administers a medical evacuation and repatriation policy for
scientists who have a J-1 visa and whose health insurance does not
contain those benefits.
5. Social and Academic CenterIn 1975 the FAES acquired a large
building at the corner of Cedar Lane and Old Georgetown Road and
renovated it for use as a Social and Academic Center. The Center is
available to FAES members on a rental basis for social or academic
functions. In addition, FAES members may reserve the Center, free of
charge, for lunchtime seminars.
Courses numbered from 300 to 399 are for the senior and graduate
levels and are open to both (Post-baccalaureate or graduate student).
Book Service
Courses numbered from 400 to 499 are offered for graduate students
and qualified seniors.
The Foundation Bookstore is open to everyone, in or out of Government.

Textbooks for courses are stocked, as well as supplementary textbooks
recommended by the instructors. The bookstore stocks current scientific,
medical and reference books, as well as those of a more popular scientific
nature. Any books not in stock may be specially ordered.
Courses numbered from 500 and above are for graduate and
professional students only; where indicated, they may be open to others
who qualify.
Building 10, Room B1-L-101
Phone: 301-496-5272
Courses numbered 600 and above are continuing medical education

courses designed primarily as preparation for Subspecialty Board
Examinations.
The Foundation Bookstore is regularly open from 8:30 a.m. to 4:00

p.m. Monday-Friday. Extended hours are from 5:00-8:00 p.m. MondayThursday during the first week of classes each semester and from 5:007:00 p.m. on Tuesday, September 6 and Tuesday January 17.
Every effort has been made to describe the level and content of each
course as accurately as possible. Should there be any uncertainty on
the part of the student, it is his responsibility to consult the instructor for
clarification.
Foundation Bookstore hours

8:30 a.m. 4:00 p.m., Monday-Friday
***First half given in the Fall semester.
EXTENDED HOURS
Tuesday, September 6
Tuesday, January 17
5:00 p.m. 7:00 p.m.
Extension Programs
In efforts to enrich the intellectual environment for the NIH community,
to promote science and the welfare of scientists, the Foundation sponsors
the following activities (for further information call 301-496-7976):
1. FAES MembershipMembership in the FAES is open to anyone with
an interest in the promotion of scientific research and education. An
annual fee of $15 entitles the member to vote for representation on the
Board of Directors, to a 5% discount on Bookstore purchases, and use
of the Social and Academic Center. (See paragraph 5).
2. Cultural ProgramsIn the belief that research and advanced education
flourish best in a broad intellectual climate, the FAES encourages and
sponsors nonscientific programs of interest to the NIH community.
FAES sponsors the Manchester String Quartet for their monthly
Monday noontime concerts at the NIH Masur Auditorium. Through
gifts and purchases, the FAES has assembled a collection of graphics
and paintings, which are on display in the cafeterias of the NIH. Other
cultural activities are being planned for the future.
First week of classes

Monday-Thursday
5:00 p.m. 8:00 p.m.
Please note: Courses that are not on the 14 or 16 week schedule follow
a different deadline to change from credit to audit or vice-versa. Please
contact the Registrars office for date.
3. Awards, Memorial Funds, and Lecture SeriesThe FAES administers

several special funds established to encourage scholarship, recognize
scientific achievement, or contribute to human welfare. Currently, these
include the Mathilde Solowey Award in the Neurosciences, the Yoshio
Sato Memorial Fund, the Gordon Guroff Memorial Lecture Award, the
John Doppman Memorial Fund, and the Astute Clinician Research
Award. In addition, the FAES occasionally sponsors lectures in a broad
range of cultural, historical and philosophical subjects, especially
those of particular relevance to the NIH research community.
Biochemistry and Biophysics

presented in the lectures. At the end of the course, most students will have a
framework for using a DNA sequence to generate antibodies for the isolation and
characterization of the gene product and its quantization in tissues or cells.
Martin Gellert, Chairperson,

Leonid V. Chernomordik
Joan Cmarik
David Davies
Fouad Francis
Paul K. Goldsmith
Mitchell Ho
Henry Levin
Gail Seabold
Jean Tiong
Roberto Weigert
John E. Weldon
Wei Yang
BIOC 316
Structure and Function of
Biological Macromolecules
BIOC 301
Fall, 3 credits
Biochemistry I
Mitchell Ho*
Gail Seabold
Jean Tiong
John E. Weldon
BIOC 301and BIOC 302 are comprehensive survey of biochemistry at the graduate
level. BIOC 301 will cover structure and function of biological macromolecules,
as well as topics on metabolic pathways including glycolysis, citric acid cycle
and oxidative phosphorylation. It will also cover the current methods used in
biochemistry and medicine.
Textbook: Lehninger Principles of Biochemistry, 5th edition.
Course website: http://tech.groups.yahoo.com/group/bioc300/
BIOC 302
Spring, 3 credits
Biochemistry II
Mitchell Ho*
Gail Seabold
Jean Tiong
John E. Weldon
BIOC 302 is a continuation of BIOC 301. It will cover metabolism and

biosynthesis of biological macromolecules such as glycogen, fatty acid, amino
acid and nucleotide. It will cover trends applicable to medical sciences such as
the immune system and drug development.
PLEASE NOTE: THE ABOVE NEW COURSE NUMBERS AND

DESCRIPTIONS REPLACE BIOC 300 Introductory Biochemistry.
Protein Biochemistry
Spring, 2 creditsP
Paul K. Goldsmith
The course materials cover concepts, methods, and practical procedures for
the development of analytical reagents for the isolation, characterization and
quantitative analysis of proteins. The course is designed for researchers who
have not had great experience with proteins. The lectures will begin with analytical
assay theory. Protein determination methods will be discussed. The lectures will
then focus on the production of peptide specific antibodies for use as analytical
reagents. Methods such as electrophoresis, western blotting, low and high
pressure chromatography, immunoprecipitation and ELISA will then be discussed.
Protein derivitization, protocols for mass spec analysis will also be presented in
the lectures.
There are no exams in the course. Each student will be required to evaluate and
present a paper to the class which utilizes one of the techniques that have been
Wei Yang*
David Davies
Selected topics chosen from the recent advances in structural biology

with the general aim of relating structure to function. Starting from basic
principles of protein and nucleic acid structure, we shall present the
latest results in increasing order of complexity. Topics will be selected
from simple enzyme mechanisms to complex biological processes
including replication, transcription, translation, signal transduction, HIV
viral infection and immune response. These topics will expose students
to chromosome decoding, ribosome and protein synthesis, membrane
proteins, ligand-receptor interactions, and structure-based drug design.
Students will also be exposed to the methods used to determine threedimensional macromolecular structures, e.g. X-ray crystallography, NMR
and electron microscopy.
Prerequisite: A basic course in biochemistry or its equivalent.
Text book: Biochemistry by Voet & Voet or Biochemistry by Berg, Tymoczko
and Stryer
Registration limited to 50 students.

Prerequisite: Organic Chemistry or consent of the Instructor.
BIOC 315
Spring, 1 credit (8 weeks)
BIOC 433
Spring, 2 credits
Current Methodology in Nucleic Acid Structure and

Function Research
This course will focus on current methods used to examine the organization and
function of genetic information, as well as the regulation of gene expression. The
emphasis will be on gaining an understanding of basic concepts and methodology.
Recent advances in molecular biology techniques and clinical applications will be
introduced. Topics to be covered include restriction enzyme analysis, molecular
cloning, library construction, DNA sequencing and footprinting analysis, DNA
mutagenesis, microarray analysis of gene expression, and construction of
transgenic/knockout mice.
Prerequisite: BIOC 300 or equivalent.
BIOC 505
Cell Membranes and Intracellular
Trafficking
Spring, 2 credits
Leonid V. Chernomordik*
Roberto Weigert
The course will consider modern concepts relating to the structure and function of
cell membranes. Starting from the physical properties of membranes, the course
will examine membrane biogenesis, membrane dynamics, and intracellular
trafficking. Examples will be drawn from specific membrane functions in the
various organelles. Topics will include nuclear transport, ER to golgi transport,
endocytosis, carbohydrate and lipid trafficking.
Minimum of 15 students must register for course to be held.
Prerequisite: CHEM 220 and BIOC 300 or equivalent.
BIOC 527
Fall, 3 credits
Biochemistry and Metabolism

of Lipids
Fouad Francis
The objectives of this course are to address the in vivo and in vitro biochemical,
physiological and clinical characteristics of lipids and lipoproteins. The first portion
of the course will involve topics that include properties of lipids, lipid markers of
subcellular membranes, and lipid, prostaglandins and lipoprotein metabolism. The
second portion of the course will consider the current concepts relating to specific
lipid functions, lipid-protein interaction, and disorders of lipid metabolism.
Prerequisite: BIOC 300 or equivalent, and permission of instructor.
BIOC 533
Spring, 2 credits, Alternate Years 2012
The Molecular and Cellular Basis

of Intercellular Communication
Joan Cmarik
The objective of this course is to expose students to current knowledge and

experimental approaches in the field of signal transduction as presented by
invited expert lecturers who are at the leading edge in researching their respective
systems. Emphasis will be given to molecular mechanisms and applications to
human disease states. Among the signaling molecules to be considered are
growth factors, hormones, cytokines, transmembrane receptors, G proteins,
kinases and phosphatases, soluble intracellular messengers, ion channels, transacting factors and calcium-binding proteins.
BIOF 312
(See page 8)
BIOF 411
(See page 8)
BIOF 429
(See page 8)
BIOF 518
(See page 9)
BIOF 537
(See page 9)
BIOF 538
Biological Databases Design
(See page 9)
Prerequisite: M.D., Ph.D., prior course work (e.g. MEDI 211, or BIOC
301/302), or extensive experience in the field.
BIOC 539
Spring, 2 credits, Alternate Years, 2013
Recent Discoveries in Molecular Biology
Henry Levin
The objective of this postgraduate course is to present late breaking discoveries

of genetic, epigenetic, cellular, and developmental mechanisms that underlie the
fundamental processes of biology. The presentations will focus on discoveries
that reveal molecular understanding of key processes. Speakers will present
introductory material and explain how recent results impact current assumptions.
Topics discusses will include a variety f biological systems and processes. Topics
include: Transcriptional activation, RNAi mediated silencing, the function of small
noncoding RNAs, the dynamics of chromatin structure, gene shuffling in the
immune system, transposable elements, nuclear architecture, molecular control
of early development, stem cells, cell reprogramming, and development and
processing of the visual system. Each lecture will be given by a different guest
speaker chosen from among the leading research scientists at NIH. Reading
material will be made available one week prior to each lecture.
All students should have a college level understanding of basic
biochemistry, molecular biology and genetics.
Bioinformatics
New BIOF 411
Benjamin Busby, Chairperson

Carlo Artieri
Medha Bhagwat
Colleen Bollin
Benjamin Busby
Joshua L. Cherry
Aaron Gussman
Yang Huang
Rezarta Islamaj
Yoo-Ah Kim
David Kristensen
Jacqueline Major
John Malone
Aurelie Neveol
John Pepper
Pere Puigbo
Joseph Ryan
Kai Wang
Sijung Yun
_______________________________________
New BIOF 309

Fall, 1 credit (7 weeks)

Joshua L. Cherry
This course will introduce students to the Python programming language and to
general principles of computer programming. Topics will include fundamental
elements of programming such as variables, control structures, functions, and
data types; principles of good programming design and practice; introductions to
advanced topics such as algorithmic complexity, recursion, and object-oriented
programming; and the mechanics of using the Python interpreter interactively and
for executing programs. Many examples and exercises will be oriented toward
computational biology, but the course will aim to provide a firm foundation in
general programming.
Students must bring their own laptops to class and will be required to
install the Python interpreter on their laptops. This course is intended for
students with no prior computer programming experience.
Registration is limited to 15 students.
New BIOF 312

Summer, 2 credits (2012)

Colleen Bollin
This course will introduce students to the Perl programming language and
to general principles of computer programming. Class exercises will focus
on using Perl to parse, analyze, and process large bioinformatics data sets,
especially FASTA sequence data and BLAST results, as well as .bed files
derived from RNAseq data. Topics will include fundamental elements of
programming such as variables, control structures, functions; elements of
the Perl programming language used for as regular expressions and reading
and writing to files; basic program design techniques; and the use of the
Perl debugger.
Students must bring their own laptops to class and will be required to
install the Perl interpreter on their laptops. This course is intended for
students with no prior computerprogramming experience.
Tuesdays and Thursdays* in August, 2012 5:30-7:30
(*there will be no Thursday class on the last week)
Fall, 3 credits
Carlo Artieri
Ben Busby
John Malone*
The genome contains the blueprint from which cells, tissues, organs, and
organisms are built. Recently, advances in technology have allowed rapid
and cost-effective gathering of genomic sequences from cells, individuals,
populations, and different species. In a relatively short time, these advances have
birthed the field of genomics. While the building blocks of DNA consist of just 4
nucleotide types, the millions or even billions of nucleotides contained within a
genome make it a challenge to understand the complex information it contains.
This course provides a foundation for understanding the biology of the
genome. Topics covered will include DNA sequencing, genome analysis, the
structure and diversity of genome structure, evolutionary analysis of genome
biology, transcriptome and proteomic analysis, systems genomics, and the
relevance of genomics to medicine. Students will present research papers relevant
to weekly topics and conduct exercises that test concepts in genomics.
BIOF 429
Fall, 2 credits (10 weeks)

Medha Bhagwat
This course describes practical applications of publicly available bioinformatics

resources for analysis of geneomic, expression and proteomic data from a number
of organisms. Emphasis will be placed on practical step-by-step procedures,
although relevant theory will also be given in order to use the resources effectively.
The course consists of ten classes, some of these are resource based such as
BLAST or Genome Browsers and some are problem based such as Making Sense
of DNA and Protein Sequences. Each class uses a paired problems approach in
which the first of two similar problems or problem sets is solved by the instructor,
while the students watch; in the second half of the class, the students tackle the
second problem, or set of problems at their computers. The class topics are: How
to access the bioinformatics data; Sequence Analysis: Making sense of DNA and
Protein Sequences; Gene Resources: From Transcription Factor Binding Sites to
Function; Analysis of Expression Data; Protein Structural Analysis: Binding Sites
to Distant Homologs; Eukaryotic Genome Browsers; Microbial Genome Analysis;
Identification of Disease Genes; Correlation of Disease Genes to Phenotypes.
Prerequisite: A solid understanding in molecular biology.
The practical approach of this course is complimentary to both the
theoretical/applied material covered in BIOL 518 (spring) and the
Theoretical Genomics (BIOF 411) offered concurrently.
New BIOF 502
Spring, 1 credit, (8 weeks)
Medical Genomics for

Clinicians and Researchers
Medha Bhagwat*
Ben Busby
Jacqueline Major
John Pepper
This two-part course will begin with an introduction to basic concepts of genomics and informatics as they may be applied in the clinic (first eight weeks
BIOF 502), and continue with an intensive treatment of data acquisition and
analysis relevant to most of these topics (final eight weeks BIOF 552).
Introductory sessions will provide a condensed review of the biological foundations
of bioinformatics and common resources in the field. Following that, topics
covered in the first half of the course will be epidemiology, population genomics
(with a focus on the 1000- and 100,000-genomes projects), genotype phenotype
relationships, evolution of cancer, toxico(pharmaco)genomics, immunogenomics,
bacterial and viral genomes, clinical decision support, and ethics of medical
genomics.
BIOF 518
BIOF 537
Spring, 3 credits
Ben Busby
Rezarta Islamaj
Yoo-ah Kim
Aurelie Neveol
Pere Puigbo*
Joseph Ryan
Sijung Yun
Prerequisite: A solid understanding of biology, computer science or

mathematics or BIOL 429.
Registration is limited to 15 students, more may be accepted with
permission of instructor.
Colleen Bollin
Ben Busby*
Aaron Gussman
Yang Huang
Web based bioinformatic tools are useful for analysis of individual molecules
or very small datasets, but do not give researchers the accuracy and flexibility
of manipulating raw datasets required for study of biological systems. With this
in mind, we have designed a 16 week course where students will analyze large
biological datasets. Experimental design and biological project integration will be
a major theme of the course. After meeting with Dr. Busby to design an individual
biologically oriented
research project before the class begins, students will acquire and organize raw
datasets (shell scripting) and annotations into databases (mySql); output data
from databases as well as multiple web hits into files, and do higher order analysis
(such as tree building) with perl; followed by Bayesian, Boolean, and multifactorial
analysis of datasets using R, and use MATLAB as a way to describe/evaluate
trends originating from large datasets.
Prerequisites: This will be an intense and challenging course. Please take it
only if you have some basic experience with bioinformatics (or have taken Biol
518).
Students will be expected to have their own laptop computers preferably
pre-equipped with a way to run linux. If that is not possible, special
arrangements must be made with the instructors before the first class.
When registering for the course, please submit a non-governmental email
address to the registrar.
New BIOF 538

Biological Databases Design
The objective of this course is to give students an introduction into the theory and
practice of a wide range of bioinformatic techniques and applications, enabling
them to use these tools in their own research. This course will be divided into
four modules: acquisition and analysis of sequence datasets, analysis of genomic
datasets from an evolutionary perspective, network analysis of genomic and
systems datasets (including natural language processing, and analysis and
prediction of protein structure. Three of the four sessions in each module will
be divided roughly 50 percent theoretical lecture and 50 percent learning to
use relevant computational tools. The final session of each module will be split
between a journal club, and commencement of work on a project assigned for
each module. By the end of the course, students should be able to acquire many
types of sequence data, identify similar genes, domains and motifs, identify gene
transfer events and alternative splicing, generate and analyze transcriptional and
gene expression networks, analyze proteomic data and make a prediction of
peptide structure from primary sequence.
Fall, 3 credits
Spring, 3 credits
Medha Bhagwat
Ben Busby
Aaron Gussman*
Kai Wang
This course will introduce students to a broad range of techniques and tools useful
for the design and management of innovative biological databases.
Introductory sessions will provide a condensed review of the biological foundations
of bioinformatics and common resources in the field. Subsequent classes will
cover a mix of technical issues as well as non-computational skills. Technical
issues will include hardware requirements, data capture using ontologies, and
database optimization and efficiency. Non-computational classes will cover
topics such as requirements analysis and user support. Later classes will
explore newer technologies in boinformatics, such as virtualization and cloud
computing, GIS, and non-relational databases. Students will explore the practical
application of these technologies to bioinformatics and computational biology.
Audience: The course is intended for students familiar with programming
and basic database design who would like to improve their understanding of
technologies useful for developing bioinformatics databases. Students will be
expected to participate in a class blog.
Prerequisites: Course participation is limited to students with previous
experience creating and using databases in a UNIX/LINUX environment, or by
instructor permission (completion of **Computational Biology 537** is also an
acceptable prerequisite). Students are expected to bring a laptop to class and to
install an Ubuntu Virtual Machine on said laptop.
Bioinformatics continued
New BIOF 552

Medical Genomics for Clinicians
and Researchers
Biology and Genetics

B
Spring, 1 credit (8 weeks)
Medha Bhagwat*
Ben Busby
Jacqueline Major
John Pepper
This is the second half of the course (BIOF 502 first half) and will include a
hands-on treatment of GWAS, expression and proteomics, current mathematical
issues in epidemiology, comparative analysis of microbial and viral genomes, and
systems biology.
Audience: The first half of the course (BIOF 502) is intended for clinicians and
researchers interested in medical genomics. The second half of the course is
intended for students familiar with programming who would like to learn how to
query and analyze data from large medically relevant datasets. Students will be
expected to participate in class surveys, projects and journal article presentations.
Prerequisites: A basic understanding of genetics would be very helpful in the
first half of the course. For the second half of the course, participation is limited
to students with previous experience parsing large flat files, or by instructor
permission (completion of **Computational Biology 537** is also an acceptable
prerequisite). For the second part of the course, students are expected to
bring a laptop to class. Students taking the second half of the course will likely
benefit greatly from taking the first half, and therefore are required to take it,
except in exceptional circumstances, with permission of instructor.
Registration is limited to 20 students ( first half is BIOF 502).
Debrorah Hinton, Chairperson

D
Robert S. Adelstein
Mawadda Al-Naeeli
Sankar Adhya
Sheri Bale
Barbara B. Biesecker
Leslie G. Biesecker
Andres Buonanno
Ruth Chia
Lijin Dong
Monique Dubois-Dalcq
Michael G. Espey
Fanette Fontaine
Claudia Gebert
Suzanne Hart
BIOL 101
Miles Herkenham
Deborah Hinton
Susan Mackem
Anne Madeo
Maximillan Muenke
Yosuke Mukoyama
Constance T. Noguchi
Vicente Notario
Erik Read
Philip Wang
Matthew Wenham
Xuehua Xu
Carlos A. Zarate, Jr
Fall, 2 credits, Alternate Years, 2012
IIntroductory Biology
Vicente Notario
In
Introductory Biology will be conducted at the level of a first year college course. It
is intended to provide a broad understanding of biological principles sufficient to
pprepare the beginning student for more advanced courses in biology and molecular
bbiology. The focus of the course emphasizes molecular and classical biology.
BIOL 102
Spring, 2 credits
I
Introductory
Molecular
Biology-Genetics
B
Ruth Chia
Fanette Fontaine
Erik Read*
Biology 102 is designed as an introduction to molecular and genetic aspects of

B
bbiology. Topics include Mendelian genetics, prokaryotic and eukaryotic molecular
ggenetics, and gene cloning.
Prerequisites: Biology 101 or college level basic biology.
BIOL 262
Fall, 2 credits, 2012
M
Molecular
Approaches
tto Studying Diseases
Philip Wang
This
lecture discussion based course is designed to help students gain an
T
appreciation
of techniques including molecular, cellular, biochemical, transgenic
a
animal
models, and imaging techniques. Students will learn a historical perspective
a
of
o technique development, discuss applications and explore recent advances
using
these specific approaches. Diseases that will be addressed include both
u
monogenic
and polygenic diseases of complex origin.
m
Prerequisites: Undergraduate Biology and Chemistry.
10
BIOL 317
Molecular and Cell Biology
Fall, 2 credits
Mawadda Al-Naeeli
Lijin Dong
Michael G. Espey*
Matt Wenham
Xuehua Xu
This course offers a broad overview of cell biology, exploring the molecular basis
of cellular structure and function. Sample topics include cellular metabolism,
organelle structure and function, gene expression, cell signaling, and the cell
cycle. The course will also address experimental approaches to studying cell
biology and the pathological consequences of abnormal cellular function.
Textbook content will be supplemented with recent literature.
There is a suggested prerequisite of biology 101 or one semester of
college-level biology.
BIOL 319
This course introduces students to stem cells and their associated niches. Topics
include types of stem cell niches and signaling pathways used. The different
types of stem cells covered will include embryonic, hematopoietic, mesenchymal,
germline, epidermal and neural stem cells. This course will cover techniques used
to study stem cells in the laboratory, applications of stem cells and potential for
the treatment of diseases.
Basic Human Neuroanatomy
Fall, 3 credits
Miles Herkenham
This course will review the major structures and neuronal pathways of the human
brain starting with those found in the spinal cord and moving to medulla, pons,
cerebellum, midbrain, hypothalamus and thalamus, and finishing with the limbic
system, basal ganglia, hippocampus and cerebral cortex. Brain development will
be used as an aid in appreciation of structures and connectivity. A functional
neuroanatomical description will be given to sensory (somatic and autonomic),
motor, association, extrapyramidal, and limbic systems. Some consideration
will be given to the relationship between cortical areas defined on the basis
of cytoarchitectonics and areas of the human brain as parceled out by brain
imaging techniques. The major differences in the anatomy of brains of humans
as compared to other species more commonly used in research settings will be
covered. The goal of this course is to educate those doing animal and human
brain research who want to become familiar with basic neuroanatomy.
Prerequisite: BIOL 101 or equivalent.
Modern Developmental Biology
Robert S. Adelstein*
Susan Mackem
Yosuke Mukoyama
Constance T. Noguchi
This course will survey the fundamentals as well as recent progress in vertebrate
development including stem cell biology. The first half of each class will consist
of a lecture based on a relevant chapter in the latest edition of Scott Gilberts
textbook, Developmental Biology. The second half of each class will be devoted to
presentation and discussion of important articles from the current literature, based
on the lecture. The emphasis will be on the mechanisms underlying vertebrate
development.
Course objective: After attending this course, the participant should be able to
discuss the developmental processes that can be affected by genetic mutations
giving rise to genetic diseases.
Prerequisite: Biology 101 or college level biology.
BIOL 338
Stem Cells and Their Niches
BIOL 325
BIOL 327
Fall & Spring, 1 credit each semester (8 weeks)
Epigenetics and Medical Disorders
Claudia Gebert
Aberrant regulation of the epigenome has been associated with the onset of many
human diseases including development disorders and cancer. The objective of
this course are to give students an overview of the most common epigenetic
mechanisms known to date and how, if gone awry, they relate to the pathogenesis
of a particular disease. Each class will focus on a human medical disorder and
discuss the epigenetic mechanisms involved in the pathogenesis of this disorder
as well as diagnostic tools and available treatment options. By the end of the
course, students can expect to have a basic understanding of DNA methylation,
histone modifications, genomic imprinting, and X chromosome inactivation, and
disorders associated with aberrations in epigenetic regulatory mechanisms.
Prerequisites: Prior particular knowledge on epigenetics is not required to
attend this course, however, introductory biology knowledge is desired.
BIOL 435
Current Trends in the
Neurobiology of Mental Illness
Fall, 3 credits, Alternate Years
Carlos A. Zarate, Jr.
The objective of this graduate level course is to provide an overview to the

biological basis of major neuropsychiatric disorders, as well as to explore the
emerging methodologies (both basic sciences and clinical) being utilized in the
study of these brain disorders. A group of leading scientists and clinicians has been
recruited to provide lectures in their areas of expertise, and each is responsible
for weekly course objectives. Disorders to be covered include bipolar disorder,
major depression, anxiety disorders, schizophrenia, childhood onset psychiatric
disorders, and substance dependence. Speakers will discuss the evidence
supporting current theories related to each disorder, with particular emphasis on
the limitations of current methodologies, the prospects for the greatest advances,
and their individual contributions to the field. Additionally, specific lectures will
focus on methodologies that are rapidly having a major impact on neuroscience
research, as well as advancing our understanding of neural function and disease
mechanisms. The methodologies to be discussed will include positron imaging
tomography, magnetic resonance imaging (functional and structural), animal
11
Biology and Genetics continued

models, biochemical techniques, genetic and epidemiological analysis, and
statistical modeling used in the study of these disorders. Students enrolled in the
course will be expected to develop a broad knowledge of the scope, impact, and
biological basis of mental illness, an understanding of the advanced techniques
used to study these illnesses, and familiarity with recent and groundbreaking novel
research in the field.
Prerequisites: A familiarity with college level neurobiology, biochemistry, and
genetics.
BIOL 504
Developmental and
Synaptic Neuroplasticity
Andres Buonanno*
Monique Dubois-Dalcq
The objectives of this course is to present an overview of the distinct cellular

and molecular mechanisms governing the unique capacity of the brain to adapt
to an ever changing environment during development, and in the adult. The
course will focus on how embryonic and adult neural cells can adopt distinct
phenotypes during development, and on how activity-dependent mechanisms
modulate neurotransmission and synaptic strength. The sixteenweek course will
be taught by NIH scientists working on cutting edge research on developmental
and synaptic plasticity, who will discuss the current themes and multi-disciplinary
approaches used to investigate these topics. Four classes will be dedicated to
student presentations and open discussions. The specific topics that will be
covered include: neuronal development and determination, neural stem cells and
adult progenitors, synapse morphology and ultrastructure, mechanisms regulating
neurotransmitter receptor trafficking, synaptic plasticity at excitatory and inhibitory
synapses, regulation of presynaptic release, and experience-dependent
development of sensory systems.
Prerequisites: Familiarity with college or graduate level neuroscience.
GENE 415
Sankar Adhya*
Deborah Hinton
This course examines the ways in which cells regulate gene expression using
model systems, including E.coli and bacteriophages. The course emphasizes
the genetic and biochemical approaches that are used to study regulation.
Mechanisms of transcriptional, translational, and post-translational control will be
included, and comparisons made between mechanisms used in prokaryotes and
eukaryotes. The interaction of regulatory mechanisms into complex regulatory
circuits will be discussed, using both classic examples and selected topics from
the latest lectures.
Prerequisites: Microbial genetics and biochemistry.
GENE 500
Year, 2 credits each semester
Suzanne Hart*
Maximillian Muenke
The objective of this two-semester course is to provide an introduction to clinical

and human genetics for fellows and genetic counseling students who are preparing
for subspecialty examinations of the American Board of Medical Genetics and
for others who wish to learn about the expanding role of genetics in medicine.
The first semester will introduce basic concepts of genetics, cytogenetics and
molecular genetics. The second semester will include presentations on clinical
topics emphasizing the diagnosis and management of patients with genetic
disorders. Topics to be covered in the fall semester include Mendelian and nonMendelian inheritance, congenital malformations, dysmorphology, teratology,
storage disorders and other inborn errors of metabolism, mitosis, meiosis,
structural abnormalities and segregation, X chromosome inactivation, new
advances in cytogenetic technology including FISH, the molecular organization,
regulation and manipulation of genes. In the Spring semester, topics will include
genetic polymorphism and disease susceptibility, DNA diagnosis, prenatal and
pre-implantation diagnosis, multifactorial inheritance, population genetics, linkage
analysis, oncogenes, tumor suppressor genes, the molecular basis of breast
and colon cancer and relevant counseling issues, genetic disorders of specific
organ systems, newborn screening, gene therapy, the consumers view of genetic
services and ethics and genetic technology. This course should impart basic
principles of genetics as applied to medicine and provide an approach to a patient
with a suspected genetic disorder.
Audience: Fellows and genetic counseling students who are preparing for
subspecialty examinations of the American Board of Medical Genetics and for
others who wish to learn about the expanding role of genetics in medicine.
Course objective: After attending this course the participant should be able
to describe current advances in human genetics and manifestation in clinical
disease and outline the current clinical practice for diagnosis and treatment of
patients with genetic disorders.
Prerequisites: Graduate level training or experience in the biomedical
sciences or consent of the course coordinator.
GENE 505
Fall, 1 credit, Alternate Years
Embryology, Developmental Biology and

Human Malformations
Tuition: $145
Leslie G. Biesecker
Class will meet Wednesday 5:30pm -6:30pm

The objective of this course is to familiarize the students with modern
developmental biology and the use of this knowledge to understand common
human malformations. The course will begin with lectures on the methodology and
model systems of developmental biology, a review of preimplantation development
and gastrulation, and embryogenesis/organogenesis. Subsequent lectures will
focus on the development of several organ systems (e.g. central nervous system,
cardiovascular, limb, urogenital, gut/respiratory, and craniofacial). These six
systems will be covered in two lectures each. New this year will be several lectures
that delve into several developmental genetic pathways in detail. A closing lecture
on developmental pleiotropy will round out the course.
Prerequisite: Permission of the course coordinator.
12
GENE 510
Fall and Spring, 4 credits each semester
Genetic Counseling: Professional

Topics Seminar
GENE 644
A Review of Medical Genetics

Barbara B. Biesecker*
Anne Madeo
Sherri Bale and guest lecturers
Tuition: $580
Class will meet Wednesdays 5:30pm-7:30pm
Tuition $580 per semester

Class will meet Fridays 2:30 - 4:30 p.m.
The objective of this course is to address the psychological, clinical, social, and
ethical issues in genetic counseling. This is a required course for the graduate
students enrolled in the JHU/NHGRI Genetic Counseling Training Program. It
is also an opportunity for college graduates interested in genetic counseling to
learn about theoretical and practical aspects of the profession. This class offers a
dynamic forum for discussion focusing on genetics counseling research, policy and
education and their impact on clinical practice. A diverse group of professionals
present topics well suited for class discussions. Student led case presentations
highlight the psychological, social and ethical issues in genetic counseling.
Clients who have had personal experiences with a genetic condition or risk expose
students to a variety of attitudes, reactions and experiences. Students enrolled in
related graduate programs are encouraged to enroll to maximize the opportunity
for exchange among disciplines.
Prerequisite: Permission of one of the instructors.
GENE 514
Current Concepts in Clinical Molecular
Genetics and Molecular Diagnostics
Spring, 1 credit
Prerequisite: Board candidate for any subspecialty exam of the American

Board of Medical Genetics.
BIOC 539
Recent Discoveries in
Molecular Biology
(See page 7)
BIOF 312
(See page 8)
BIOF 411
(See page 8)
Suzanne Hart
Tuition: $145.00
Class will meet Thursdays 5:30pm-6:30pm
The objective of this course is to provide a review of molecular diagnosis of
common hereditary or neoplastic disorders for which DNA based diagnosis is now
in routine use. Topics include FGFR3 disorders, fetal blood typing, thrombophilias,
hemochromatosis, fragile X syndrome, polyglutamine disorders, hereditary breast
cancers, Charcot Marie Tooth and spinal muscular atrophy, PraderWilli and
Angelman syndromes, mitochondrial diseases, Duchenne and Becker muscular
dystrophy, cystic fibrosis, and Smith-Lemli-Opitz Syndrome. There will also be
sessions on genetic risk prediction using linkage and Bayesian analysis as well
as a class on DNA forensics and paternity testing. The course is designed as part
of the required curriculum for Clinical Genetics residents and fellows preparing for
the Clinical Molecular Genetics boards given by the American Board of Medical
Genetics.
Prerequisite: GENE 500 and permission of the instructor.
The objective of this course is to provide a review for candidates for the American
Board of Medical Genetics Subspecialty examinations (clinical genetics, molecular
genetics, biochemical genetics, cytogenetics, and genetic counseling). Topics
to be covered include statistical and mathematical subjects in clinical genetics
and population genetics, clinical cytogenetics, dysmorphology, ophthalmologic
genetics, and general treatment and management of genetic diseases.
BIOF 429
(See page 8)
BIOF 502
Medical Genomics for
Clinicians and Researchers
(See page 9)
BIOF 518
(See page 9)
BIOF 537
(See page 9)
BIOF 538
Biology Databases Design
(See page 9)
BIOF 552
(See page 10)
STAT 435
(See page 34)
13
Biotechnology (BIO-TRAC)
R/M Nardone Associates, Inc. 301-496-8290
(Course Content) www.biotrac.com
nardonem@mail.nih.gov
Fee: $850.00 (2 credits)
Monday, September 19 Friday, September 23, 2011

Lecture: 9:00 a.m. - 4:00 p.m. (Mon) & 8:30 a.m. 11:30 a.m. (Tue-Fri)
301-496-2316
Course Information: BIO-TRAC is a series of daytime Biotechnology

Training Courses offered by the FAES under contract with R/M Nardone
Associates, Inc. These workshops, which are team taught by active
researchers, include lecture and hands-on laboratory exercises. Each
participant receives a comprehensive binder containing all materials
presented in the workshop along with laboratory protocols and reference
materials.
Space is limited in each workshop with registration on a first-come-firstserved-basis.
Fees: Three day lecture and laboratory workshop$750; Four day
lecture and laboratory workshop $795; Five day lecture and laboratory
workshop $850.
Check www.biotrac.com for latest date, course content information,
cancellation and refund policies.
Academic Credit: Although no grades are given for BIO-TRAC courses,
a registrant completing a lecture/laboratory course will have earned two
credits, or one credit for a lecture course alone. Upon completion of each
TRAC, a certificate is issued.
Scholarship: The Pierre Renault Memorial Scholarship Fund (supported
by R/M Nardone Associates, Inc.) provides a full or partial scholarship
annually for a guest researcher at the NIH with restricted income.
Completed applications should be returned to the FAES office by
August 31, 2011 for TRACs beginning in September and January and
by December 31, 2011 for TRACs beginning in March, June and July. An
application may be requested by calling 301-496-2316.
Online Registration: Students who have taken previous BioTrac courses
will need to email Priyanka Basa at basap@mail.nih.gov to request a
new password. New students can create an account at www.faes.org
and follow the online instructions on how to register. Online registrations
paying with check, purchase order or training nomination form will not
be completed until payment is received (mail or walk-in) within five (5)
business days.
Limited Enrollment: Each TRAC has limited enrollment; please register
in advance, by mail. Mail registrations are accepted on a first-come, firstserved basis. The deadline for mail registration (TRAC courses ONLY) is
one week before the first day of each TRAC. Each completed registration
will be confirmed by e-mail. If you are unable to register before the mail
registration deadline, please call 301-496-2316 for space availability and
walk-in registration procedures.
Contract Basis Only Workshop: The indicated workshop will not be
offered in the upcoming year. The workshop is currently available only
on a contract basis between the FAES and your organization or institute.
Custom Designed Courses: In addition to the courses listed below,
the FAES is able to provide custom designed training programs in
biotechnology. If you would like to have a program specifically designed
for individuals in your Branch, Laboratory, or Organization, please call
301-496-8290 for further information.
14
(35 hours of lecture and laboratory training)
Biotechnology Techniques
FAES
(Registration Information)
TRAC 1
Laboratory: 12:30 - 5:30 p.m. (Tues-Fri)

This lecture and laboratory course will provide the theoretical basis and the handson experience needed for the understanding and execution of those laboratory
procedures that are widely used in biotechnology, molecular genetics, immunology,
and biochemistry. While the subject matter will be discussed in the context of
broadly stated research objectives, the emphasis will be on the techniques rather
than on specific applications and strategies. Thus, the participants will acquire skill
in the use of generic methods, and through an understanding of such methods,
improve their effectiveness as workers in a contemporary research laboratory.
Lecture and Laboratory Topics Include: Recombinant DNA, Separation,
and Monoclonal Antibody. Procedures: these will include Gel Electrophoresis
(acrylamide and agarose); Column Chromatography; Immunocytochemistry;
ELISA; Spectrophotometry (quantitation; enzyme kinetics); Nucleic Acid
Purification and Molecular Weight Determinations; Cell Separation Methods;
Protein Separation and Quantitation; Liquid Scintillation (double label) Counting;
Autoradiography (cellular and gross); and Restriction Enzyme Mapping; Gene
Expression; Oligonucleotide Synthesis.
TRAC 2
(18 hours of lecture 20 hours laboratory training)
Recombinant DNA Methodology I
Fee: $850, 2 credits
TRAC 2-SM Monday, June 4 Friday, June 8, 2012

Lecture: 8:30 - 11:30 a.m. (M-Th) & 9:00 a.m. - 4:00 p.m. (Fri)
Laboratory: 12:30 - 5:30 p.m. (M-Th)
This lecture and laboratory course is designed to provide the novice with an
introduction to recombinant DNA technology. An approach emphasizing both
principles and methodology provides the scientist with the essential fundamentals
needed for gene cloning and for an appreciation of the strategies of recombinant
DNA technology.
Lecture and Laboratory Topics Include: The Power of Recombinant DNA
Technology-its advantages and applications; Recombinant DNA Safety Guidelines;
Vector-Host Systems; Isolation of Nucleic Acids; Construction of Genomic
Libraries; Extraction and Purification of mRNA from Eukaryotic Cells; Synthesis of
cDNA; Construction of cDNA Libraries; Restriction Enzymes; Analysis of Nucleic
Acids by Gel Electrophoresis, Southern and Northern Analysis; Transformation and
Transfection of Prokaryotes and Eukaryotes with Recombinant DNA Molecules;
Identification and Analysis of Recombinant DNA Clones; Vector Systems which
allow for the Expression of the Cloned Fragments in the Bacterial Host; Screening
for Differentially Expressed Genes; DNA Microarrays; Special Expression Vector
System; Strategies in Applying Recombinant DNA.
TRAC 3
Recombinant DNA Methodology II
This workshop is only available on a contract basis only.
Contact Mark Nardone at nardonem@mail.nih.gov for further information.
This lecture and laboratory course complements TRAC 2 and is intended for
those who are familiar with basic methods of recombinant DNA using plasmids
and prokaryotic cells. This course will build on that information and focus on the
use of eukaryotic recombinant DNA systems including newer vectors, selected
host systems, and specialized techniques and applications which stem from
opportunities created by recombinant DNA.
Topics: Construction of cDNA Libraries in Lambda Phage Vectors; Special
Vectors and Hybrid Vectors; Synthesis of Gene Probes; Yeast: Cloning Systems
and Host of Foreign DNA; Transient and Stable Expression of Recombinant DNA
in Mammalian Cells; Viral Expression Vectors; Baculovirus System for Protein
Synthesis; PCR - Methods and Applications; Eukaryotic Gene Expression:
Analysis of Control Mechanisms; Nucleic Acid Probe Technology; Mapping
and Characterization of Complex Genomes; Nucleic Acid Cycle Sequencing;
Applications of Antisense DNA; Current and Future Applications of Recombinant
DNA; Screening of Phage Using Oligonucleotide Probes; In Vitro Mutagenesis;
Transient Transfection Assays; Two-Hybrid System to Identify Protein Interaction In
Vivo; Microarray Construction and Use; Proteomics.
TRAC 4
Cellular Immunology: Principles

and Methods
Monday, February 27 Friday, March 2, 2012

Lecture and Laboratory Training Course: 9:00 a.m. - 5:00 p.m.
The objective of this course, through lecture and laboratory sessions, is to learn
those research approaches which form the foundation of our understanding of the
immune system, with particular emphasis on the cellular elements and their roles in
the orchestration of the immune response. Because this field is contributing to novel
therapies and is in a high state of flux, due attention will be given to new directions.
Lecture and Laboratory Topics Include: The Cellular Basis of Immunity; Clonal
Selection; Immunological Memory and Clonal Expansion; Antibody as Antigen
Specific Receptor; Antibody Diversity and B Cell Development; Antigen-Driven
Somatic Hypermutation: C3 Protein Cleavage and Complement Activation; B
Cell Activation; T Lymphocytes and Cell Mediated Immunity; T Cell Classes and
Responses: Cytotoxic, Helper, and Suppressor T Cells; Separation of Lymphocytes
by FACS, Adherence, Ficoll/Hypaque, and Cytotoxicity; Chemotactic, Proliferation,
and Phagocytosis Assays; Cytokines: Classification and Assays; cDNA Probes
for Cytokine Identification; Use of Antibodies to Distinguish Mixed Interleukin
Activities; Nutrition, Maintenance and Cloning of Lymphoid Cell Lines; Cell Line
Immortalization: Methods and Applications; The Cellular Immunology - Gene
Therapy - Immunotherapy Nexus.
TRAC 5
Separation Techniques
This lecture and laboratory course is designed to provide theoretical and practical
knowledge of current methods of separation and detection of the components in
biological samples.
Lecture and Laboratory Topics Include: Separation Strategies; Ion
Exchange and Gel Permeation Chromatography; Affinity Chromatography and
Chromatofocusing; Denaturing and Non-Denaturing Gel Electrophoresis; Agarose
Gel Electrophoresis; Pulse Field Gel Electrophoresis; PAGE; Separation and
Purification Strategies; Analytical and Preparative Centrifugation; Protein and
Nucleic Acid Detection and Determination; Immunoblotting and ELISA Procedures;
Medium and High Pressure Liquid Chromatography (HPLC) of Proteins and
Nucleic Acids; Nucleic Acid Separation, Characterization and Hybridization; 2-D

Gel Electrophoresis; Capillary Electrophoresis; Magnetic Bead Technology; Cell
Fractionation and Separation.
TRAC 6
Cellular and Molecular Basis for the
Understanding, Diagnosis and
Therapy of Cancer
The objective of this lecture/lab course is to present an integrated view of cancer
studies at the cellular and molecular level with human cancer diagnosis and
therapy in a clinical setting.
Lecture and Laboratory Topics Include: Human Carcinogenesis: An overview
of Symptomology, Pathological Sequalae, Diagnosis, and Therapeutic Strategies;
Genetic and Epigenetic Events in Carcinogenesis; Cell Transformation:
Cytogenetic, Behavioral, Oncogene and Tumor Suppressor Gene Changes;
Protooncogenes, Oncogenes, Signal Transduction and Cell Cycle Regulation;
Non-Random Chromosome Aberrations and Cancer; Use of in Situ Hybridization
with Tissue Sections and Chromosome Preparations for Diagnosis; Model
Systems for the Study of Receptors and Cancer: Interleukin2, Colony Stimulating
Factor, and Epidermal Growth Receptors; Molecular Genetic Analysis of Breast
and Colorectal Cancer; Apoptosis and Prostate Cancer; Angiogenesis and
Metastasis; Application of Microarray and siRNA Technologies; Cancer Cell
Markers and Screening.
TRAC 7
Animal and Human Cell Culture:

Methods and Applications
Monday, May 21 Friday, May 25, 2012

Lecture: 9:00 - 4:00 (Mon) & 8:30 - 11:30 (Tues-Fri)
Laboratory: 12:30 - 5:30 p.m. (Tues-Fri)
This lecture and laboratory course is structured to provide life scientists who are
not experienced in cell culture with an introduction to principles and practices
that will facilitate their ability to develop the use of in vitro systems. The course
is predicated on the application of the most rigorous principles of quality control.
Lecture Topics: From Donor to Cell Lines: Comparison of Methods, Endothelial
Cells from Aorta, Chick Embryo Culture, Human Skin Fibroblasts, Hepatic Cells;
Explants and Cell Cultures; Contrasting Properties of Normal and Transformed
Cells: Finite Life Span; Senescence and Telomeres; Transfection with Telomerase
Gene; Mutagenesis and Carcinogenesis Assays; The in vitro environment: Sterility;
Judicious use of Antibiotics, Mycoplasma Effects and Testing, The 2005 Consensus
Document on Good Tissue Culture Practices; Low Density and Clonal Growth:
Methods and use in Evaluation of Nutrients, Cell Proliferation, and Cytotoxicity;
Cell Hybridization, Somatic Cell Genetics and Gene Mapping to Chromosomes;
Cell Line Identification and Authentication: Karyology, Isoenzymes, Short Tandem
Repeats. Cross Contamination: Causes and Prevention; Karyotyping: Solid and
G-banding. Chromosome Aberrations; Cell Culture and Biotechnology Interface:
Transfection and Selection, Use of Genetically Engineered Cells for Medical/
Commercial Applications, Suspension and Mass Culture Techniques; Cell Culture
Repositories: Starting and Maintaining a Cell Bank; Immortalized Cells.
Laboratory Topics: Subculturing 3 Different Cell Lines: Cell Counting and Cell
15
Biotechnology (BIO-TRAC) continued

Viability; Chick Embryo Culture; Gross Cytology of Cells: Staining, Morphological
Changes During the Cell Cycle; Colchicine Synchronization; Metaphase Spreads;
Solid Staining and G-banding; Cloning: Cloning by Limited Dilution and Plating
efficiency; Transformed Cells: Growth Patterns, Growth in Soft Agar, and Aggregate
Formation; Chemiluminescent Assays for Cell proliferation and Evaluation of
Toxins; Transfection of Cells, Telomerase Assay; Apoptosis; Isoenzyme Assay for
Detection of Interspecies Cross-Contamination.
TRAC 8
Immunochemistry and Monoclonal

Antibody Production
Monday, April 23 Friday, April 27, 2012

Lecture: 9:00 - 4:00 (Mon) & 8:30 - 11:30 (Tues-Fri)
Laboratory: 12:30 - 5:30 (Tues-Fri)
The objective of this lecture and laboratory course is to provide investigators with
information on approaches to the isolation, purification and characterization of
antibodies and antigens. Special emphasis will be given to monoclonal antibody
production, assay, and characterization.
Lecture and Laboratory Topics Include: The Immune Response; Immunoglobulin
Structure and Diversity; Immunogenetics; Antigenic Determinants; Idiotypic
Network; Application of Monoclonal Antibodies; Cell Fusion; Myeloma Cell Lines;
Screening for Monoclonal Antibodies (ELISA, Immunofluorescence, RIA); Cloning;
Purification and Characterization Approaches; Human Monoclonal Antibody
Formation and Use; Purification of Antibodies from Serum, Ascites, and Culture
Supernatant; Analysis of Antibody-Antigen Reactions by Immunoprecipitation and
Equilibrium Dialysis; Affinity Determinations; Production of Idiotypic Antibodies,
Antibody Fragments, and Novel Antibodies; Peptide Carriers and Antigen
Synthesis; Crosslinking Assays for Cell Surface Receptors; Immunocytochemistry;
Recombinant DNA Approaches.
TRAC 9
Polymerase Chain Reaction and
Molecular Hybridization Technology
of Chemical and Cellular Samples; Hybridization Formats: Target Abundance

vs. Probe Abundance, Spots/ Blots, Southern and Northern Analysis, Soluble
Targets, in situ Hybridization; Radioactive, Biotinylated, DNP, Chemiluminescent
and Oligonucleotide Probe Synthesis, Purification and Use; Label and Signal
Amplification and Hybridization Accelerators.
TRAC 10
Protein DNA Interactions:

Gene Specific and Epigenetic
Regulation of Expression of the Mammalian Genome
Monday, November 14 - Friday, November 18, 2011
Lecture and Laboratory Training Course: 9:00 - 5:00
Although the Human Genome Project has successfully elucidated an incredible
amount of structural information contained within the human and other genomes,
much current and future effort is and will be devoted to understanding how the
expression of this genetic information is regulated and how the interactions
between the vast array of expressed proteins is controlled. The identification and
analysis of protein-nucleic acid interactions is one of the most rapidly expanding
and exciting areas of cell and molecular biology. This lecture and laboratory course
will review the conventions and experimental approaches that are important in
studying proteins which interact with DNA and RNA molecules. Special emphasis
will be placed on transcriptional regulation, homeoboxes, epigenetic regulation
and hormone responsive elements. A course focused on gene regulation would
not be complete without discussion of the newest transcriptional regulators,
siRNAs.
Lecture and Laboratory Topics Include: The Role of Transcriptional Regulators
in Cell Biology; HoxA9 and HoxDNA Interactions; Transcriptional Regulation of the
Telomerase hTERT Gene as a Target for Cellular and Viral Oncogenic Mechanisms;
Methods and Experimental Approaches for Studying DNA Protein Interactions;
Interactions of DNA with Steroid, Thyroid, and Retinoic Acid Receptor Complexes;
Lsh, an Epigenetic Regulator of the Mammalian Genome; Motifs of DNA Binding
Proteins; Basal Transcription Factors and Coactivators in Eukaryotes; Reporter
Genes for Transcription Factor Analysis; SUMO Modification: Regulator of Proteinprotein and Protein-nucleic Acid Interactions; Regulation of Gene Expression
by the Homeodomain: Tertiary Structure, Dynamics, and Transgenic Alterations;
siRNA and Regulation of Gene Expression.

See Trac 26 and Trac 37 for one week PCR offerings.
TRAC 11
Genome Analysis
This lecture and laboratory course will focus on two important technologies which
share strong interfaces with basic molecular biology research, genetics, molecular
pathology (including cancer and genetic diseases), and identification of viral,
bacterial and protozoan pathogens, namely the polymerase chain reaction and
molecular hybridization technology.
TBA
Lecture and Laboratory Topics Include: The Polymerase Chain Reaction Topics
include PCR and its Optimization, Thermostable DNA Polymerases; Amplification
of Genomic DNA and cDNA; Use for RNA Amplification and mRNA Quantitation;
Probes and Primers: Primer Design; Synthesis and Labeling; Research
Applications: Recombinant PCR, Cloning, Sequencing, DNA Polymorphisms,
Screening of Libraries; Clinical and Forensic Applications; Sample Preparation;
Detection of Viruses and Bacteria; Oncogenes and Cancer; Familial Relationships;
in situ PCR and PRINS; Contamination Control.
The Molecular Hybridization Topics include Probe Design, Optimization, and
Application at the Chemical and Cytological Levels; Principles of Hybridization;
Base Structure, Modification, Stability and Specificity; Tm and Cot1/2; Preparation
16
TRAC 12
Transgenic Technology:
Methods and Applications
Monday, January 9 Friday, January 13, 2012

Lecture and lab: 9:00 a.m. - 5:00 p.m.
This lecture/laboratory demonstration course is intended for those who wish
to develop a strong background in transgenic techniques and applications.
The two dominant approaches to transgenic technology will be emphasized,
namely classic transgenic production by pronuclear microinjection and knockout
transgenic production (gene targeting) by blastocyst injection with embryonic
stem (ES) cells. The comprehensive coverage will address supporting technology
(e.g. cryopreservation, rederivation, Intracytoplasmic Sperm Injection (ICSI), In

Vitro Fertilization (IVF), animal husbandry and surgery) as well as the molecular
biology/recombinant DNA aspects of transgenesis.
Lecture and Laboratory Topics Include: Transgenic Technology overview
(Embryonic Development, Optimizing Constructs for in vivo Expression,
Preparation of Females for Embryo Collection, Pronuclear Microinjection,
Generation of Pseudopregnant Females, Implantantation in Foster Mothers,
Identification of Transgenic Progeny, Optimization of Breeding Population from
Founders); Lentiviral and BAC transgenisis; Gene Targeted Transgenisis (Isolation
and Maintenance of Totipotent embryonic Stem Cells for the Generation of
Chimeric Mice; Homologous Recombination in ES Cells; Construct Design,
Transfection, Selection; Generation of Gene Knockout Mice using Targeted ES
Cells; Blastocyst Injection; Optimizing Germ-line Chimeras); Alternative Methods
for Generating Targeted Mice: 8-cell Embryo Injection and ES Cell Aggregation;
Transgenic Phenotype Analysis; ransgenic Animal Model Supporting Techniques
(Cryopreservation and rederivation; ICSI and IVF; Transgenic Model Future
Prospects); Transgenic Model Future Prospects; Sampling Project Question and
Answer; Live and Video Demonstrations and hands on work (e.g. microinjection;
Superovulation; Embryo Harvest and Transfer).
The objective of this course is to provide the student with a good theoretical
background as well as practical information and laboratory experience in the
design, expression, detection and purification of recombinant proteins from a
variety of expression systems.
Lecture and Laboratory Topics Include: Introduction to Protein Purification
Techniques; Expression of Proteins in Prokaryotic and Eukaryotic Cells;
Requirements, Advantages and Disadvantages; Prokaryotic Expression Systems;
Strains, Tags and Purification Systems; Expression in Insect Cells: Baculovirus and
Drosophila Systems; Expression in Mammalian Cells: Detection and Purification
(Immunohistochemistry, Reporter Gene Assays, GFP, Tags for Expression/
Purification Systems); Generation of Antibodies to Recombinant Proteins: System
Considerations and Antibody Purification; Expression in Yeast Cells (Pichia).
TRAC 18
Stem Cells
Monday, October 3 Friday, October 7, 2011

Monday, March 5 Friday, March 9, 2012
Lecture and Laboratory Training Course: 9:00 am - 5:00 pm
TRAC 15
The emergence of stem cells as important tools for biomedical research prompts
this offering of a 5 day, lecture-lab training course on stem cells.
Two Hybrid Selection: Identification Fee: $795.00 (1 credit)

and Characterization of Protein-Protein Interaction
The lectures will cover the importance, origin, and fate of diverse stem cells
(hematopoietic, muscle, nerve, skin and embryonal) and the factors that control
their differentiation. Special emphasis will be on isolation, identification, culture,
and use of stem cells and their progeny.
Tuesday, January 17 - Friday, January 20, 2012

To characterize a proteins function, it is often advantageous to identify other
proteins with which it interacts. The Yeast Two-Hybrid system is one of the
most versatile methods available for detection and characterization of proteinprotein interactions, and in the recent years it has become a mature and robust
technology. It has successfully been used to detect proteins and peptides that
target specific motifs in proteins, to define the domains of amino acids critical
for such interactions, and to score specific drug-mediated disruption of proteinprotein interaction. It has also been applied to detect interactions between DNA
and proteins, RNA and proteins, and between small molecules/drugs and proteins.
This lecture/laboratory course is designed to provide the student with all the
information, experience and most of the reagents necessary to design and
perform Two-Hybrid selection in the laboratory setting. Emphasis will be placed
on practical experimental design as well as good theoretical understanding of the
systems advantages and limitations.
Lecture and Laboratory Topics Include: Practical recommendations for yeast
work; background on Two- Hybrid selection in yeast; Bait construction and
Assessment; Library screening; Characterization and confirmation of positive
candidates; False positives; Overview of YTH modifications and competing
systems; Brief overview of Dual Bait system; Yeast transformation; Replica Plating;
Gal-13 Assays (quantitative and qualitative); Mating Assay; PCR from yeast; DNA
isolation from yeast.
TRAC 16
Expression, Detection & Purification

of Recombinant Proteins in
Prokaryotic & Eukaryotic Cells
Fee: $750.00 (1 credit)
Wednesday, November 30 Friday, December 2, 2011

Lecture and laboratory training course: 9:00 a.m. 5:00 p.m.
Lecture and Laboratory Topics Include: Bone Marrow Stem Cell Plasticity;
Hematopoietic Stem Cells; Cell Lines as Models of Stem Cells; Flow Cytometry
and Stem Cell Isolation and Characterization; Murine embryonic Stem Cells;
Mesenchymal Stem Cells; Differentiation of Stem Cells into Bone; Isolation of
Cells from Bone Marrow Collection; Histology Marrow vs. Peripheral Blood; Liver
Stem Cells; Stem Cells in CNS; Differentiation of Hemotopoietic Cells; Stem Cell
Transplantation: Re-engineering the Immune System; Regulatory Perspective
Regarding Stem Cells and Gene Therapy.
TRAC 19
Mutation Detection and Analysis:

Molecular Approaches
The object of this lecture and laboratory course is to provide attendees with
an understanding of the skills required for molecular approaches to mutation
detection and analysis and their relation to molecular medicine and basic
biological research. The detection of mutations and their molecular basis has
become a very important aspect of molecular medicine as well as environmental
effects studies. A variety of techniques have been developed to identify deletions,
insertions, and point mutations in DNA as well as chromosome aberrations that
can lead to genetic disorders. This 3 day lecture/laboratory course will provide the
participant with an understanding of the most current electrophoretic, chemical,
enzymatic, molecular biological and in vitro approaches to mutation detection and
analysis of chromosomal and mitochondrial genes.
Lecture and Laboratory Topics Include: Mechanisms of Mutagenesis; Chemical
Approaches to Mutation Detection - HOT; Mutational Analysis Using Enzymatic
Reactions - Ribonuclease and T4 Endonuclease VII Assays for Point Mutations;
17

Triplet Repeat Analysis Using RED; Molecular Biological Approaches for Mutation
Detection and Quantitation - PCR/RFLP, Competitive Primer Extension, Ligase
Chain Reaction, and Oligonucleotide Arrays. The Protein Truncation Test (PTT)
and in vitro Mutagenesis Strategies; SNPs; Multiplex PCR; Binary Probes.
TRAC 20
Immunocytochemistry
Fee: $750.00 (1 credit)
Wednesday, March 21 Friday, March 23, 2012

Immunocytochemistry is an important research tool which has significant
applications in topics as important and diverse as basic cell biology, carcinogenesis,
apoptosis, genomics, clinical diagnosis, and intracellular migration and localization
of molecules. This 3 day lecture and lab course will introduce the participants to
the key methods and applications of immunocytochemistry and their underlying
principles.
Lecture and Laboratory Topics Include: Introduction to Immunofluorescence;
Conjugation of Proteins with Flurochromes; Tissue Preparation for
Immunocytochemistry; Immunocytochemistry on Whole Mount Preparations;
In situ Hybridization with Immunoprobes; Labeling and Flow Analysis of Cells;
Applications of Flow Cytometry and Confocal Microscopy. Preparation of and
Fluorescent Labeling of Cultured Cells; ABC-Peroxidase and Acid Phophatase
Labeling of Sectioned Material; ELISA on Fixed Cells; Fluorescein Labeling of
Nerve Cells in Whole Mount.
and in situ hybridization techniques. The application of these techniques to

current research questions in genetics and gene expression, molecular pathology,
and pathogen detection and identification will be discussed. Probe application
and detection systems will serve as the basis for both RNA and DNA in situ
hybridization techniques to be addressed in lecture and laboratory. This course
will be staffed by clinical and basic scientists familiar with the applications of
hybridization techniques to the problems of human disease.
Lecture and Laboratory Topics Include: Probe Design, Optimization, and
Application at the Chemical and Cytological Levels; Principles of Hybridization; Base
Structure, Modification, Stability and Specificity; Hybridization Kinetics; Preparation
of Chemical and Cellular Samples; Hybridization Formats: Target Abundance
vs. Probe Abundance, Spots/ Blots, Southern and Northern Analysis, Soluble
Targets, in situ Hybridization; Radioactive, Biotinylated, DNP, Chemoluminescent
and Oligonucleotide Probe Synthesis, Purification and Use; Label and Signal
Amplification and Hybridization Accelerators. DNA in situ hybridization (FISH);
Interphase Molecular Cytogenetics; RNA in situ Hybridization; RT-PCR in situ
Hybridization; Principles of Karyotyping and Metaphase Chromosome Preparation;
Tissue and Specimen Preparation Fixatives, Comparative Genome Hybridization;
Spectral Karyotyping; Fluorescence Microscopy; and in situ PCR.
TRAC 23
Flow Cytometry:
Principles and Methods
Fee: $795.00 (1 credit)
Monday, November 7 Thursday, November 10, 2011
TRAC 21
Monday, May 7 Thursday, May 10, 2011

Mitochondrial Molecular Biology

and Pathology Workshop
Fee: $750.00 (1 credit)
Tuesday, May 22 Thursday, May 24, 2012

The purpose of this three day workshop is to provide a foundation of knowledge to
those beginning to investigate mitochondrial function and biogenesis or those simply
interested in understanding these essential subcellular organelles. Participants will
learn about the important metabolic reactions occurring within the mitochondria
and how nuclear and mitochondrial DNA lesions can result in a wide variety of
mitochondrial disorders. The workshop will include a combination of lectures and
hands-on laboratory experiments designed to familiarize the participants with the skills
necessary to work with these organelles.
Lecture and Laboratory Topics Include: Structure and Function of Mitochondria;
Replication of Mitochondrial DNA and Mitochondrial Genetics; Transcription and
Processing of Mitochondrial RNA; Mitochondrial Protein Synthesis and Import;
Molecular Methods for Working with Mitochondria; Mitochondrial Disorders; Molecular
Lesions, Phenotypes, Mutation Detection and Approaches to Therapy; Isolation of
Mammalian Mitochondria; Marker Enzyme Assays; Isolation of mtDNA and RNA; PCR
Amplification of mtDNA from Total Cellular DNA; Mutation Detection by PCR/RFLP.
Lecture and Laboratory Training Course: 9:00am - 5:00pm

This four day lecture/laboratory workshop will cover various applications of
flow cytometry in basic research. Selected lecture topics will provide a broad
background about the functions of a flow cytometer; choice of fluorochromes; data
analysis and presentation; technical protocols for flow cytometric procedures and
troubleshooting during data acquisition and analysis.
Lecture and Laboratory Topics: Basic Setup of Flow Cytometers; Principle of
Cell Sorting; Parameters for Sorting; Alternative Separation Techniques (Including
Magnetic Bead Separation MACS); Choice of Fluorochromes Depending on the
type of Instrument and Application; Parameters of Analysis, Data Analysis and
Interpretation; In-depth Discussion of Examples of Various Flow Cytometric Assays
(e.g. Cell Cycle Analysis, Cell Activation, Apoptosis, Immunology, Hematology,
Biochemistry with Methodical Protocols); Multi-color Analysis (With Special
Emphasis on How to Combine Fluorochromes and Fluorescence Compensation);
Choosing the Right Controls for Data Analysis (Isotype Controls; Blocking with
Antibodies); Software; Laser Scanning Cytometry.
TRAC 24
DNA Microarrays: Principles and

Applications of DNA Microarrays
TRAC 22
Hybridization Techniques:
Fee: $795.00 (1 credit)
Labeling, Detection and Applications

Tuesday, April 17 Friday, April 20, 2012
This 4 day course is designed to introduce the participant to molecular hybridization
18
Monday, January 30 Friday, February 3, 2012

Lecture and Laboratory Training Course: 9:00 am to 5:00pm
Global transcription patterns as well as nucleotide polymorphisms can now be readily
evaluated using DNA microarrays. This functional genomics technology offers a
powerful, non biased approach to the analysis of molecular mechanisms associated
with any type of physiological change in a cell. Moreover, DNA microarrays have
become a prominent technological tool for genotype characterization. This lecture
and laboratory course will show how DNA microarrays can be used for different
applications in the biomedical sciences and will introduce hands-on training to a

complex yet exciting technology.
Lecture Topics: Overview of DNA microarrays; Transcriptional analysis from single
genes to whole genomes; Types and applications of microarrays; Use of microarrays
for genotyping; comparative genome hybridization providing a molecular karyotype
of the genome; Fabrication of DNA microarrays; microarray data analysis; Concepts
of microarray bioinformatics; Dove-tailing expression data to genome sequences and
other types of functional genomics; genotyping and resequencing using genechip
technology; high throughput profiling platforms: development of tools for diagnosis
and management of disease; introduction of new technologies microfluidicsgenerated microarrays with in situ synthesized probes, Illumina bead technology.
Laboratory Topics: Isolation of total RNA; purification and quantitation of mRNA;
fluorescent labeling of cDNA; Hybridization of cDNA to DNA arrays; Scanning and
data collection; Analysis and display of data using clustering programs; Validation of
microarray expression analysis by real-time and conventional RT-PCR.
TRAC 25
Proteomics: Principles and Methods

Monday, March 26 Friday, March 30, 2012
This lecture and laboratory course will provide an introduction to proteomics technology.
Both principles and advanced methodologies will be discussed with an emphasis on
protein identification tools, shotgun sequencing and bioinformatics technologies.
Topics: The power of 2D electrophoresis: its advantages, applications and data
analysis tools for the examination of the spots of interest; high-throughput mass
spectrometric-based protein identification: spot excision, in situ proteolysis, extraction
of the cleavage products from the gel matrix, peptide purification and concentration
as well as mass spectrometric sample preparation and analysis; isotope-coded
affinity tag methods to identify and quantify low-abundance and membrane proteins;
Introduction to LC-MS/MS analysis of samples using 1D or 2D high performance liquid
chromatography to maximize dynamic range; methods for optimizing identification
of low abundance proteins from complex biological mixtures; Introduction to de
novo sequencing of mass spectra data and the use of database search algorithms
to identify proteins from mass spectrometry data; protein arrays for gene expression
and molecular interaction screening; novel algorithms for protein sequence alignment
to generate protein identities from partial or complete databases; new systems for
obtaining detailed functional information and large-scale classification of proteins;
homology modeling for predicting the 3D details of biomolecules of unknown structure.
Cycle; Primer Design and Usage including Tools for Primer Design; Thermostable
DNA Polymerases; Optimization; PCR Additives; Contamination Control; Reverse
Transcription PCR (RT-PCR); PCR Mutagenesis; Cycle Sequencing; Long
Range PCR; 5- and 3-RACE PCR; Clinical and Forensic Applications; Practical
Modifications to PCR.
TRAC 28
Angiogenesis: Analytical Techniques

for the Quantitation of Angiogenesis
and Lymphoangiogenesis
Fee: $850.00 (1 credit)
Tuesday, October 25 Friday, October 28, 2011

Lecture and Laboratory Training Course: 9:00 - 5:00
The growth of blood vessels, a process known as angiogenesis, is essential in normal
physiology and its imbalance contributes to numerous disorders including cancer and
age-related macular degeneration. Antiangiogenic compounds are regarded as a
very promising therapeutic tool for treatment of cancer and several other disorders.
The NCI Angiogenesis Core Facility and the FAES are co-sponsoring a hands-on four
day training course on analytical techniques used to assess the in vitro/in vivo growth
of blood vessel and lymphatic endothelial cells.
The course will be structured to have a combination of wet labs and lectures
covering this subject matter. Hands-on operational training of the following
techniques will be covered: 1) Chorioallantoic Membrane Assay (CAM), 2)
Rat Aortic Ring Assay, 3) Directed In Vivo Angiogenesis Assay (DIVAA), 4)
Endothelial Cell Migration Assay and 5) Endothelial Cell Tube Formation
Assay. Please contact Dr. Zudaire for an updated description of the course.
Lecture Topics: Angiogenesis and its Regulation by Redox Signaling; Angiogenesis
and Tumor Endothelial Markers (TEM); Therapies Targeting Tumor Angiogenesis;
Imaging of Lymphangiogenesis; ECIS - A Morphological Biosensor for Cell Research;
DIVVA: A Novel Method for Measuring Angiogenesis
Laboratory Topics: Rat Aortic Ring Assay; Chick embryo chorioallantoic membrane
(CAM) Assay; Tube Formation Assay; Growth Assay with Fluorescent Cells; Adhesion,
Migration (ECIS) Tube Formation Assay; DIVVA CAM Assay
Course Director - Dr. Enrique Zudaire - NCI Angiogenesis Core Facility - zudairee@
mail.nih.gov
TRAC 29
Laser Capture Microdissection

Fee: $850.00 (1 credit)
(LCM): Methods for Microgenomic Analysis
Monday, August 1 Friday, August 5, 2011
TRAC 26
PCR Methodology: Principles,

Optimization and Applications
Fee: $795.00 (1 credit)
Tuesday, July 12 Friday, July 15, 2011

From its conception in 1983 to its modern day use in a myriad of clinical and
research applications, the Polymerase Chain Reaction (PCR) has revolutionized
modern molecular biology. This lecture and laboratory course will focus on the
Polymerase Chain Reaction and its applications in basic molecular biology
research, genetics, molecular pathology, including cancer and genetic diseases
and identification of viral, bacterial and other pathogens.
Lecture and Laboratory Topics Include: Basic PCR; Dissection of the PCR
Lecture and Laboratory Training Course: (9:00 - 5:00)

Laser Microdissection systems allow for the procurement of specific populations
of cells from tissue and cytology and live cell culture samples containing
heterogeneous populations of cells. The specificity of analyses is therefore much
more representative of the disease process being studied. This approach to
microdissection ensures that biological molecules, such as RNA and DNA and
proteins, remain undamaged during the microdissection process. Downstream
molecular analysis of these molecules produces accurate and assured results that
have led to over 2,000 peer-reviewed publications by independent researchers.
In this five-day training program, participants learn to prepare tissue specimens
for microdissection, then select and acquire homogenous cell populations using
the mmi-CellCut, Leica LMD, Arcturus XT, and PALM microdissection systems.
Instruction emphasizes operation of these LM systems, appropriate tissue
19

handling and sample preparation for subsequent DNA, RNA or protein analysis,
and methods for proper molecular extraction. Lecture and detailed instructions
to prepare samples for several downstream molecular analyses are presented.
Topics: Overview of Laser Microdissection Technology (History, Theory, Applications);
Tissue Sample and Slide preparation; Project set up and QC of microdissected samples,
genomic analysis, mRNA analysis including quantitative RT-PCR gene expression
analysis and microarrays from microdissected tissue samples, microRNA analysis
from microdissected samples, and proteomic analysis from frozen and formalin-fixed,
paraffin-embedded microdissected samples using Mass Spec. Special microdissection
techniques such as immuno-guided LM and live cells dissections will be also covered.
The lectures also include examples of actual scientific and clinical applications of LMbased studies. The hands on sessions include tissue slide preparation and histology
review for LM, and practice on Arcturus XT, PALM, Leica and mmi-CellCut platforms.
TRAC 32
Nanotechnology in Medicine
Fee: $750.00 (1 credit)
Wednesday, April 11 Friday, April 13, 2012

Small Interfering RNA (siRNA) and

Functional Genomics
Monday, October 17 - Friday, October 21, 2011

Lecture and Laboratory Training Course: 9:00 a.m. 5:00 p.m.
Studies of posttranscriptional gene silencing (PTGS) led to the discovery of the
phenomenon of RNA interference (RNAi) and the role-played in that process by small
interfering RNA (siRNA). Although only recently identified, siRNA molecules already
are taking the research world by storm as their potential as functional genomic tools
is beginning to be appreciated. Compared to antisense and knockout techniques,
siRNA can more rapidly and effectively create loss-of-function phenotypes and
they may even provide an approach for gene therapy. In this hands-on lecture/lab
workshop participants will learn the latest information about RNAi and the use of
siRNA as a functional genomics tool.
Lectures: Overview: Antisense, Gene knockouts, and siRNA; Gene Silencing and
siRNAs; Delivery of siRNA to Eukaryotic Cells; DICER/RISC and the Mechanism of
Action of RNAi; Chromosome Remodeling with Small RNAs; Development of siRNAs;
RNAi and Epigenetics; siRNA and Cancer; RNAi and Drug Discovery; Design of
siRNAs. Labs: Comparison of Chemically Synthesized and in vitro Transcribed
siRNAs to Induce Gene Silencing; Inducing Gene Silencing using siRNA Expression
Plasmids Under Transient Selection; Silencing Gene Expression by PCR Based
siRNA Expression Cassettes; Preparing siRNA Cocktails.
TRAC 31
Laboratory: injection routes, gene gun immunization, preparing vaccine

emulsions, evaluating immune sera by ELISA and Western Blot.
Wednesday, October 12 - Friday, October 14, 2011
TRAC 30
clinic, molecular (designer) adjuvants; Immunization strategies (regimen, route

of immunization); Monitoring the immune response and evaluation of vaccine
efficacy (in vitro assays such as ELISA, immunofluorescence assays, ELISPOT;
Flow cytometry will be discussed in context with intracellular staining, tetramer
staining and phenotyping of vaccine reactive cells).
Vaccines: Development and

Evaluation of Efficacy
Fee: $750.00 (1 credit)
Wednesday, September 7 Friday, September 9, 2011

Wednesday, February 15 Friday, February 17, 2012
Vaccines are used or developed for a wide range of diseases such as cancer,
autoimmune diseases, allergies, and for the prevention of communicable and
parasitic diseases. The purpose of this course is to provide an overview of a broad
spectrum of vaccine related topics and their mode of action making it valuable for
any scientist working with or on vaccines regardless of the participants scientific
background.
Nanotechnology has exploded onto the scientific scene in the last few years and has
impacted nearly every area of scientific research. The infancy of nanotechnology
began in materials science laboratories. The field of nanotechnology has matured
and is now at the forefront of medical research. Nanomedicine has been heralded
as the next big thing. Popular literature promises tiny machines that will have
a huge impact on disease and aging. The reality is that nanomedicine can be
divided into three basic categories: tiny machines, diagnostics, and therapeutic
delivery. This course will discuss all of these nanotechnology applications and
focus on preparation and use of different nanotechnologies.
Next generation nanomedicine technologies are being developed to provide
continuous and linked molecular diagnostics and therapeutics. Research is being
performed to develop nano-engineered systems which will seek out diseased
(e.g. cancerous) cells, enter those living cells, and either perform repairs or
induce those cells to die through apoptosis. These nanomedicine systems
are being constructed to be autonomous, much like present-day vaccines,
but will have sophisticated targeting, sensing, and feedback control systems
superior to conventional antibody-based therapies. The fundamental concept of
nanomedicine is not to just kill all aberrant cells by surgery, radiation therapy, or
chemotherapy. Rather it is to fix cells, when appropriate, one cell-at-a time, to
preserve and re-build organ systems. This technology is currently being developed
to treat diseases such as cancer, retinopathy of prematurity, and diabetes.
In this three-day training program, participants will learn the history of
nanotechnology in medicine through reading and discussing the primary
literature. Participants will learn about the preparation and clinical use of
different nanotechnologies. In laboratory sessions, participants will prepare
and characterize two such systems. These techniques will then be used to in a
bioassay to deliver material to cells in vitro. Lecture and detailed instructions to
generate and characterize nanoparticles for diagnostics and therapeutic delivery
will also be included.
Topics: Introduction to nanotechnology in cancer; Dendrimer MRI contrast agents:
synthesis and application; Nanomaterial characterization: Light scattering and
EM; Synthesis and application of liposomes for drug delivery; Silica nanotubes
for drug delivery; Application of nanotechnology for clinical diagnosis; Analysis of
nanomaterial interaction with biological systems; PEGylated colloidal gold-TNF
nanomedicine - from manufacturing to pre-clinical assessment.
Topics: Overview of the immune system and the induction of an immune response
highlighting crucial factors for vaccinology; protein and peptide vaccines, viral
vaccines (pox and avipox viruses; adenoviruses), bacterial vaccines; Cutting edge
vaccines such as DNA vaccines, pulsed dendritic cells, nanoparticles; Purpose of
adjuvants, classes of adjuvants with in depth discussion of adjuvants used in the
20
TRAC 33
Clinical Proteomics and

Biomarker Discovery
Monday, June 20 - Friday, June 24, 2011

The emerging field of Clinical Proteomics involves the discovery and identification
of new biomarkers which may aid in diagnosis of disease, prediction of clinical
outcome, and therapeutic efficacy. Technologies are now available which allow
for rapid comparisons of protein expression profiles from complex biological
samples, creating novel opportunities in biomarker discovery from a host of
diseases. Successful biomarker discovery projects include the coordination of
many different disciplines, such as biochemistry, proteomics, clinical chemistry
and bioinformatics. In this course, the student will be exposed to the challenges
facing researchers involved in biomarker discovery projects, as well as to the
numerous analytical platforms that may be employed.
Topics: Study Design and Sample Collection/Storage; Sample Handling and
Preparation (Chromatographic methods to reduce the complexity of the sample,
such as ion exchange chromatography, abundant protein removal); Analytical
tools for the measurement of quantitative difference between clinical samples (2D
gel electrophoresis, including DIGE; SELDI-TOF-MS, Multiplex Protein/Cytokine
Arrays, Differential isotopic labeling, such as ICAT, iTRAC); Quality Control and
Reproducibility in Measurements; Data analysis utilizing multivariate statistics.
Fluorescence microscopy is a useful tool for observing cellular morphology and

function that is readily available and relatively simple to learn. Any specimens
prepared for fluorescence microscopy can be analyzed in further detail and
with improved resolution using confocal or laser scanning microscopy. Confocal
microscopy is a powerful technique for examining 3 dimensional localization and
dynamics of cellular components.
Lectures: Fluorescence Microscopy: Introduction and description of principles;
Specimen preparation; Applications; Confocal Microscopy in Biomedical Research:
Different types of confocal microscopes and their uses; META multicolor; Two
Photon imaging live animals such as mice; Spinning Disk improved resolution for
examining movement of organelles and molecules in living cells; Co-localization
and Interaction of Proteins: Differences between Co-localization and interaction;
Importance of preventing emission and excitation crosstalk; Using FRET to show
protein protein interactions; Live Cell Studies: Using FRAP and FLIP to look at cell
dynamics; Using time series to look at translocation of proteins.
Laboratory Topics: Sample preparation for fluorescence microscopy;
acquisition of Basic Confocal Scans using LSM 510, META, Multiphoton, and
Spinning Disk; Co-localization using multifluorescence imaging; Protein Protein
Interaction (Fluorescence Resonance Energy Transfer FRET); Live Cell imaging:
Translocation and localization of proteins using fluorescent fusion proteins and
time lapse imaging; Protein Dynamics using fluorescence loss in photobleaching
(FLIP) and fluorescence recovery after photobleaching (FRAP); Photosections of
thick specimens; Using (flil.EGFP) Zebrafish.
TRAC 34
TRAC 36
Advanced Microarray Analysis and

Pathway Integration
Fee: $795.00 (1 credit)

In response to the growing demand to learn how to extract maximum information
from the tremendous amount of data generated in a micorarray experiment,
BioTrac 34 picks up where the BioTrac 24, DNA Microarrays: Fabrication and
Applications left off. Beginning with a hybridized array, this four day course will
spend extensive time on optimizing the scanning process and acquiring an
informative scan. This data will then be analyzed using GeneSpring software to
generate clustering associations. Finally, using microarray and protein interaction
data, pathways defining gene interactions will be assessed using PathwayAssist
software.
Lecture and Laboratory Topics Include: Microarray Scanning and Acquisition of
a Good Image; Analysis of Microarray Data by GeneSpring; Managing Microarray
Data; Pathway Analysis; Laboratories will Include Scanning a Microarray and
Computerbased Experiments Involving Analysis and Manipulation of the Data
Using Such Programs as QuantArray, GeneSpring and PathwayAssist.
Immunofluorescence and
Confocal Microscopy
Cell Line Identification

& Authentication
Monday, May 23 - Thursday, May 26, 2011
TRAC 35
Fee: $795.00 (1 credit)

Laboratories using cultured mammalian cells run the risk of cross-contamination
and misidentification of their cell lines. It has been estimated that as many as 20
percent of the cell lines being used for research are not what they are purported to
be. Furthermore, the problem continues to grow. Reliable procedures for cell line
identification and authentication exist and should be among the important quality
control measures practiced by those responsible for the integrity of research.
After a review of well documented cases and preventative measures, this 3
day lecture and hands-on laboratory course will focus on the three most
useful methods for authentication and detection of intra and interspecies crosscontamination. 1. Karvolop: basic karyotyping, G and C chromosome banding;
marker chromosomes; fluorescent in situ hybridization (FISH); spectral karyotyping.
2. IsoenzMes: genetic and evolutionary basis of isoenzymes; protein/isoenzyme
extraction; separation and identification of isoenzyme patterns; application to
interspecies identification. 3. DNA Fingerprinting/Short Tandem Repeats (STR):
genetic and evolutionary basis of DNA fingerprinting; allele selection, detection,
and characterization; number of alleles characterized and certitude; DNA profiles/
base sequences; multiplex PCR and primer selection; separation by slab gel
electrophoresis and capillary electrophoresis; use of automatic sequencers and
fluorescent label detection. Also, cell type identification by intermediate filament
immunocytochemistry and proper design of a cell bank will be discussed.
Tuesday, May 1 Friday, May 4, 2012

Lecture and Laboratory Training Course: Tues - 12:00 5:00; Wed Fri 9:00a.m.
5:00p.m
This three day and a half day lecture and hands-on-laboratory course will focus
on two important methods that are used extensively in biomedical research.
21

TRAC 37
Real Time and Quantitative PCR
$795.00 (1 credit)
Monday, July 18 - Thursday, July 21, 2011

Tuesday, January 24 - Friday, January 27, 2012
Lecture and Laboratory Training Course: 9:00 am - 5: 00 pm
Conventional PCR has revolutionized the detection and analysis of nucleic
acids. However, one of its major limitations has been the inability to accurately
quantitate the amount of product, which reflects the amount of starting material,
due to differing plateau effects among multiple samples. The need to accurately
determine quantitative changes in gene expression has led to the adoption of realtime RT-PCR as the method of choice not only for quantitative gene expression
but also for validating results obtained from array analyses and other techniques
that evaluate gene expression changes on a global scale. This lecture/laboratory
course is intended for those who have a fundamental background in PCR and will
address the basic chemistries of real time PCR and the many platforms available.
Lecture and Laboratory Topics Include: Introduction to Real-Time
Sample Processing: DNA/RNA Extraction and Purification for Real-Time
Probe Chemistries and Real-Time Instrumentation including Amplification
Three Different Platforms; Assay Development; Quantitative Real-Time
Multiplex Real Time PCR.
PCR;
PCR;
using
PCR;
TRAC 38
Digital Imaging in Microscopy
Fee: $750.00 (1 credit)
Tuesday, June 14 Thursday, June 16, 2011

Imaging of cells and tissue through the microscope in years past had embraced
the use of film to capture pertinent events. Improvements in recent years have
led to the insurgence of digital imaging techniques which allows for considerably
more flexibility and accuracy in obtaining these images. Digital imaging effectively
addresses the demands of high resolution, color accuracy, speed of acquisition,
imaging flexibility and low cost, all of which are demanded by the field today.
Areas to address in this course will include information related to effective imaging
through the microscope as it relates to the camera itself as well as appropriate
microscope setup to allow for optimal results in the lab situation.
Lecture and Laboratory Topics Include: Characteristics of a wide range of
digital cameras (i.e. resolution vs. sensitivity); Computer selection parameters;
Appropriate filter selection for the microscope (i.e. narrow band vs. wide band and
imaging techniques to optimize signal localization); Advantages of microscope
motorization for digital imaging and 3D rendering (ie Z-stack acquisition); Multiple
location imaging (including time lapse); Incubation for live cell imaging; Optical
sectioning (i.e. Apotome and Deconvolution); Physiological imaging (i.e. Calcium
Imaging); Tissue Microarray imaging; Total Internal Reflection Microscopy.
These topics will all be discussed in lecture format by specialists in the individual
fields from both the research field as well as from industry where appropriate.
Daily laboratory classes will be included for part of each day to allow for hands on
experience with a variety of imaging systems.
TRAC 39
Epigenetics
Fee: $795.00 (1 credit)

Tuesday, December 6 Friday, December 9, 2011
Tuesday, February 7 - Friday, February 10, 2012
Sequencing of the human genome was not the endpoint of our goal in understanding
human genetics. The chemical modifications to DNA and the chemical interactions
involving the manufacture of proteins represents a second level of human genetics
termed, epigenetics or epigenomics. Epigenetics refers to the study of heritable
changes in gene expression that occur without a change in DNA sequence. Research
has shown that epigenetic mechanisms provide an additional layer of transcriptional
control that regulates how genes are expressed. Epigenetic abnormalities are
associated with genetic disorders, cancer, autoimmune diseases, aging and pediatric
syndromes, among others.
This course will address the basic principles of epigenetics, the role of epigenetic
mechanisms in normal development and human disease, and the development
of epigenetically-effective drugs. The objective of the program is to provide a
solid foundation of information enabling participants to design experiments when
returning to their own research lab. Furthermore to provide a solid background in
order to understand the literature in this rapidly growing field.
Participating instructors are primarily active researchers from neighboring institutes
and universities who have been publishing in these areas for several years.
Topics: Lectures cover basic mechanism underlying DNA methylation, histone
modification, chromatin organization, noncoding RNA, and gene repression.
Moreover, a broad range of topics will be covered in epigenetic research including
cancer, development, environmental health, and immunology. The lectures also
provide the participant with practical information concerning current techniques in
epigenetic research. For example, the application of CHARM, Illumina bead arrays,
restriction enzyme analysis, and bisulfate sequencing is discussed in designing
experiments and interpreting data.
In the laboratory, attendees gain hands-on experience in techniques including methyl
specific PCR, chromatin immunoprecipitation, and global DNA methylation assays.
TRAC 40
Protein Informatics
Fee: $750.00 (1 credit)
Wednesday, November 2 Friday, November 4, 2011

Tuesday, May 15 Thursday May 17, 2012
The logical next step after genome sequencing or proteomics analyses--and a
necessary prequel to biomarker and drug target discovery--is to identify proteins
of interest and their activities.
This three-day course will combine lectures with computer labs to provide an
introduction to the bioinformatics resources and methodologies commonly used
for protein analyses. Course participants are expected to know the basic biology
of proteins, and will leave with the ability to perform detailed analyses of protein
sequences and structures.
Lecture and Laboratory Topics Include: Database Resources & Text Searching:
where and how to look; Theory and Application of Sequence searches: BLAST,
Multiple Sequence Alignment, and Peptide/Pattern Match; Protein Classification:
background and how to construct protein families; Structure-based Analyses:
principles and tools, and how to do structure alignments and predict functional
sites; Protein Function Prediction: tour of how to do it and how to avoid pitfalls;
Biomedical Ontologies: introduction and uses; Functional Interpretation of Highthroughput Data: function and Pathway, analysis for proteomic and genomic data.
22
TRAC 41
miRNA: Tools and Technologies

for the Quantitative and Functional
Analysis in Mammalian Cells
Fee: $750.00 (1 credit)
Tuesday, November 1 Thursday, November 3, 2011

Tuesday, May 15 Thursday, May 17, 2012
MicroRNAs (miRNAs) are evolutionarily conserved, endogenous, noncoding
small RNAs that act as post-transcriptional gene regulators. miRNAs as gene
regulators play a vital role in many biological processes. In addition to normal
human development involving cell growth and proliferation, tissue differentiation,
embryonic development, and apoptosis, human diseases are also impacted by
miRNAs. Mutation, dysfunction, and/or dysregulation of miRNAs may give rise
to diseases such as coronary artery disease, cancer, diabetes, AIDS, hepatitis,
and obesity.
In this hands-on training workshop, participants will learn the latest information
about miRNA and the use of miRNA as a diagnostic tool.
Lecture Topics: Overview of miRNA; Quantification and Functional Analysis of
miRNA in Mammalian Cells; Profiling on miRNA and miRNA in a Mouse Model
for Adipocyte Differentiation; Discovering and Expression of miRNA; Regulation
of the Immune System by miRNA; miRNA Expression Patterns in Colon Cancer;
Bioinformatic Analysis and Discovery of miRNA; Use of RNAs for Profiling in
Mammalian Cells
Laboratory Topics: Isolation of mRNA and miRNA from 3T3-L1 Cells in Pre,
During, and Post Differentiation. Spectophotometric Quantification of the RNA,
Reverse Transcription-PCR and Quantification of mRNA and miRNA Targets
Whose Expression Change During Adipogenesis. The ddCt Method to Analyze
the Data and Derive the Relative Changes in Expression of the mRNA and miRNA
Targets will be Demonstrated. Changes in Expression of miRNAs in Cancer Cells
by Array Technology and Bioinformatics Approaches for Identifying miRNAs are
also described.
TRAC 42
Junior Scientist Training Program
Fee: $4,000.00 (6 credits)
September 2011 - May 2012

Requirement
techniques in molecular biology. These selected methods have been identified by

NIH scientists and private industry representatives to be techniques that research
technicians would implement on a day-to-day basis.
Participants would also be required to view online, selected lectures (approximately
thirty hours) that are part of the current FAES Bio-Trac curriculum offered at the
NIH. These lectures, which are taught at a graduate level by local researchers, will
cover many areas of biotechnology that will introduce and reinforce the subject
matter given in the laboratory.
Participating researchers will be available to serve as mentors for interns who
participate in the program.
Results
Students will gain extensive experience in laboratory techniques that are
necessary to excel in the sciences once completed. Upon conclusion of the
program, participants would receive six graduate credits from the FAES, have
increased their competitive value for positions such as a research technician and
strengthened their graduate school or internship application if pursuing graduate
studies.
JSTP workshop outline can be found at www.Bio-Trac.com
TRAC 43
iPS Cells: Principles and Methods
Fee: $795.00 (1 credit)
Tuesday, October 11 Friday, October 14, 2011

Tuesday, March 13 Friday, March 16, 2012
The importance of induced pluripotent stem (iPS) cells in disease therapy and
developmental biology is rapidly emerging and prompts this new 3-day lecture-lab
course.
The emphasis of the course is on practical information that will help the researcher
bring iPS technology to the laboratory. The staff conducting the course includes
experts from academia and industry.
Lectures will discuss the expression of genes required for inducing pluripotency,
methods of making (virus, RNA, plasmid) and maintaining iPS cells, growth
conditions for differentiation (emphasis on hematopoietic and cardiac), and
contrasts with embryonic stem cells.
Labs will cover techniques for staining for alkaline phosphatase and
immunofluorescent markers of pluripotency on live cells. Furthermore, methods
for picking iPS colonies and DNA transfections will also be included. Although the
techniques will be conducted mostly on mouse cells, their applicability to human
cells will be discussed.
College graduates with a four-year degree in biology, require more hands-on

laboratory experience to effectively compete for research technician positions.
Goal
Provide a quality training program at the National Institutes of Health (NIH) that bridges
the gap between the level of laboratory skills biology graduates have acquired, to the
proficiency level needed to effectively compete for a laboratory technician position.
Ideal Candidates
Post Bacs, Fourth year biology majors, recent college graduates, or those in the
sciences who need to strengthen their laboratory skills.
Method
Using the FAESs Bio-Trac training resources at the NIH, selected students will
attend a nine month workshop encompassing seventeen hands-on laboratory
sessions (eighty-five contact hours) covering the latest relevant laboratory
23
Chemistry, Imaging and Physics

bonding, stereochemistry, transition state theory, mechanisms, resonance and
spectroscopy. The application of the above to synthetic organic chemistry will be
emphasized. Considerations in biochemistry, medicine and pharmacology will
be made. The first semester will be concerned primarily with structural bonding,
stereochemistry, aliphatic compounds and mechanism.
Kenneth L. Kirk, Chairperson

Darn Freedberg, Co-Chairperson
Daniel Appella
Joseph J. Barchi, Jr.
Warren J. Eresian
Darn I. Freedberg
Michal Komlosh
Belhu Metaferia
Marc Nyden
Prerequisite: General Chemistry or consent of the instructor.
CHEM 212
For students wishing to take a complete program in chemistry without prior studies
in this field, the following sequence is recommended, at the rate of one course per
semester:
CHEM 101General Chemistry I

CHEM 102General Chemistry II
CHEM 211Organic Chemistry I
CHEM 212Organic Chemistry II
CHEM 220Physical Chemistry
BIOC 300Introductory Biochemistry
CHEM 101
General Chemistry I
General Chemistry II
Year, 2 credits each semester, Alternate years
Physical Chemistry with Applications

to Biological Sciences
Marc Nyden
Fall, 3 credits
Belhu Metaferia
Spring, 3 credits
Belhu Metaferia
Prerequisite: CHEM 101
Organic Chemistry I
This is a continuation of CHEM 211. This semester will cover alcohols, esters,
carboxylic acids, amides, ethers, amines, aldehydes, and ketones with a brief
overview of some biologically relevant structures such as carbohydrates, amino
acids, DNA, RNA and lipids.
CHEM 220
This course is a continuation of CHEM 101 and will cover the following topics:
Chemical equilibrum, pH, Reaction kinetics, Redox reactions, Solubility, an
introduction to organic and biochemistry. As in CHEM 101, we will emphasize a
conceptual understanding and show how the chemistry learned here can apply to
health related situations. The course will be taught at a chemistry major level, and
will provide the background for organic chemistry, biochemistry and other health
sciences where chemistry is utilized.
CHEM 211
Darn I. Freedberg
Prerequisite: CHEM 211
This course is an introduction to Chemistry and will cover the following topics:
properties of matter, units of measurement, elements, compounds, mixtures,
conservation of mass, symbols and formulae, stoichiometry and balancing
chemical reactions, the periodic table, electronic structure, covalent bonding,
molecular structure, acid base reactions, gas laws, states of matter and solution
properties. We will emphasize a conceptual understanding and show how the
chemistry learned here can apply to health related situations. The course will be
taught at a chemistry major level, and will provide the background for organic
chemistry, biochemistry and other health sciences where chemistry is utilized.
CHEM 102
Spring, 3 credits
CHEM 220A: In the first semester of this course we will focus on the principles
of thermodynamics and their basis in kinetic theory and statistical mechanics.
The major topics will be the first and second laws of thermodynamics, chemical
and phase equilibria, solutions, transport properties and the rates of chemical
reactions. These topics will be applied to problems of biological interest including
protein structure and binding and enzyme kinetics.
CHEM 220B: In the second semester of this course we will cover the theory of
quantum mechanics and its application to chemistry. This will include an overview
of spectroscopy (IR, UV-VIS, NMR) and X-ray diffraction methods. An exposition
of modern computational techniques, which are used to study the conformations
and dynamics of biological molecules will also be presented.
Prerequisites: General chemistry and physics.
CHEM 244
Practical NMR Spectroscopy:
Basic Methods for Characterizing
Molecules
Fall, 3 credits
Darn Freedberg
The goal of the course is to introduce and flesh out the concepts already familiar
to students who may have studied them in Organic Chemistry. This course will
focus on the use and application of basic NMR concepts and methods. We will
cover chemical shifts, couplings, data acquisition, dynamic NMR, one-and-two
dimensional NMR and NOE with a practical and generally non-mathematical
focus. These will then be applied to solving problems and choosing the best
techniques for different types of molecules.
Prerequisite: One year of Organic Chemistry
Fall, 3 credits
Darn I. Freedberg
This course is a systematic study of the chemistry of carbon compounds including

alkanes, alkenes, alkynes, alkyl halides, and aromatic compounds. These
compounds will be discussed in relation to appropriate concepts of structure and
24
CHEM 327
Spring, 2 credits
The Art of Drug Design

and Discovery
Joseph J. Barchi, Jr.
The objective of this course is to explore the fundamental principles of modern

drug discovery with an emphasis on antiviral and anticancer drug design. A
brief history of the discovery of hallmark drugs such as penicillin will serve
as a backdrop for in depth discussions on state-of-the-art techniques for
target discovery and validation, lead discovery and lead optimization. Several
classes of compounds with therapeutic potential will be discussed such as
peptides, carbohydrates, nucleosides and their analogs (mimetics). The latest
methods in molecular modeling, high throughout screening and structureactivity relationships will be presented. The concept of rational drug design
based on high resolution target structures derived from NMR and X-ray
crystallography will be stressed. The course will benefit from guest lectures
from outstanding researchers in specific fields of interest.
Prerequisite: Organic chemistry.
This course is an elective for the Technology Transfer Certificate Program.
This course will be held in Frederick.
CHEM 341
Fall, 2 credits, Alternate Years
Advances in Synthetic
Organic Chemistry I
Daniel Appella
IMAG 409
Fall, 2 credits
Principles and Applications of Magnetic

Resonance Imaging (MRI) in Biomedicine
Michal Komlosh
This lecture course introduces the basic principles of Magnetic Resonance

Imaging (MRI), as well as a number of various applications of MRI to the
study of living systems. Basic elements of MRI physics, image acquisition,
and contrast mechanisms will be reviewed. A selected advanced contrast
mechanism such as molecular imaging, diffusion and flow would be covered.
As an example of clinical applications, the use of MRI in the study of the brain
will be demonstrated.
Prerequisites: First year calculus, physics and chemistry.
PHYS 201
Fall, 3 credits
Warren J. Eresian
This first part of a two semester course in general physics will cover topics in
kinematics, mechanics, work and energy, fluids, vibrations and waves, and sound.
Together with PHYS 202, this may satisfy the minimum requirement of medical and
dental schools. Knowledge of trigonometry and elementary calculus is required.
This course has no laboratory.
The first semester of this two semester review of new developments in synthetic
organic chemistry will deal with carbanion chemistry, ylids, chemistry of organo
boranes, organo cuprates, organo palladium and other organo metallics, including
Grubbs olefin metathesis. Diasterioselective and enantioselective reactions,
particularly as applied to complex syntheses, will be stressed. Methods and
examples will be taken from the recent literature.
Prerequisite: One year of organic chemistry
PHYS 202
Introductory Physics II
Spring, 3 credits
Warren J.Eresian
A continuation of PHYS 201. Topics will include heat and thermodynamics,

electricity and magnetism, optics, quantum theory, nuclear physics and
radioactivity.
This course has no laboratory.
CHEM 342
Spring, 2 credits, Alternate years, 2012
Advances in Synthetic
Daniel Appella
This is a continuation of CHEM 341 (which course is not a prerequisite). Topics

in organometallic chemistry will be continued and concluded. This will be followed
by development of the Woodward Hoffman Theory of Orbital Symmetry and its
applications. Electrocyclic reactions, cycloadditions, sigmatropic rearrangements,
and photochemical reactions will be examined, with examples taken from natural
product syntheses. Further topics will include the syntheses using free radical
cyclizations and other topics of interest to the students.
Prerequisite: One year of organic chemistry.
PHYS 245
Topics in Modern Physics Relativity,
Quantum Mechanics and Cosmology
Warren J. Eresian
Topics in Modern Physics will discuss the theoretical and experimental

considerations leading to the development of special and general relativity,
quantum mechanics and cosmology. Beginning with the historical development
of classical physics, the course will describe the discovery and applications of
special and general relativity, why quantum mechanics came to be required to
explain the microscopic world, the Big Bang and all of its ramifications, and finally,
efforts to discover the Theory of Everything. The lectures will be supplemented by
readings from selected texts.
Prerequisites: Knowledge of basic algebra and graphing is required.
25
Education and General Studies

Jeff Chyatte, Chairperson
completed the requirements for taking the MCAT and have questions about this
course please contact the instructor. This course extends beyond a review of
general knowledge of biology, chemistry, and physics. It also reviews problem
solving, critical thinking, writing skills, and knowledge of science concepts and
principles prerequisite to the study of medicine.
Jos Cceres
Jeff Chyatte
Suzanne Epstein
Jessica Krash
Reza Momenan
Patrick ODonnell
Oliver Ou
Ralitza Patheva
Katherine B. Szarama
GENL 161
The course provides you with rigorous coursework and extracurricular reading to
expand your vocabulary, develop your reading pace, and increase your familiarity
with texts and arguments in various disciplines. It enables you to spend time
devoted to reviewing the relevant material.
Art Songs:
Chamber Music with Words
Lecture with LIVE performances
Jos Cceres
Suzanne Epstein
Jessica Krash
Patrick O Donnell
Ralitza Patcheva
This course will explore art songs as chamber music for voice and piano, covering
European and American repertoire from the classical period to the 20th century.
In each session, the songs will be performed live in the original languages, both
as examples during the lecture and as an uninterrupted performance following the
lecture. Lectures will discuss the lives and times of the composers and poets, as
well as features of the particular songs. Listeners will learn to hear and appreciate
the interplay between voice and piano, differences between musical styles, and
the relationship between the music and text. These lectures are intended for music
lovers of all kinds, whether they have formal music training, a little background, or
none at all.
Limited opportunities for registered students to perform in class may be available
by special arrangement. Singers and pianists who wish to perform in class should
contact Jessica Krash.
GENL 163
Qi Guang and Tai Chi with
a Brief Review of Chinese Martial Arts
Fall, 1 credit
Reza Momenan
The course has 14 units. One unit will be covered each week. Each unit covers
a portion of Physical Sciences, Verbal Reasoning and Biological Science sections
of the exam. This is a systematic review, going through all aspects of each unit in
an organized way using an online power point slide format. Students are expected
to participate. Extensive homework will be presented in the online, multiple choice
format of the MCAT and is suitable for class, group, and individual instruction.
Students will be expected to bring a hard copy of online power point slides and
online homework to each class. They are expected to identify topics that are
unfamiliar, and use their graduate textbooks and notes where available. A study
partner may be chosen. Scores are reported in Verbal Reasoning, Physical
Sciences, Writing Sample, and Biological Sciences.
Registration is limited to 15 students. No students will be admitted after the
first day of class.
GENL 322
Fall and Spring, 1 credit each semester (8 weeks)
GRE-Review
This review course will prepare students for the Graduate Record Examinations
(GRE) General Test. We will cover the Quantitative, Verbal, and Analytical Writing
portions of the General Test with a primary focus on test content. Brief discussions
of test-taking strategies will also be included. Students will have access to a
variety of math, verbal and analytical writing practice material. The lectures will be
interactive, with student participation strongly encouraged.
GENL 511
Boot Camp for University Teaching
A brief review of the origin and history of classical martial arts in the world, with
particular focus on Chinese Martial Arts is presented in this course. Through a
series of theoretical and practical sessions, the principles of what are referred
to as internal and external martial arts are briefly reviewed. In this course,
various aspects of cultivating internal energy (Qi-pronounced Chi) through static
and dynamic meditations are discussed and practiced. Scientific evidence and
research on physiological effects of these exercises are also discussed. Several
sessions will be devoted to training various self-defense techniques. Physics and
mechanics of external martial arts are also exercised. This course will include
30% theory and 70% practical workshop. No prior experience is required.
Oliver Ou*
Katherine B. Szarama

Jeff Chyatte
This course is designed for researchers and other professionals interested in

teaching at colleges and universities. Specific topics include systematic and
proven methods of developing dynamic lectures, laboratory activities and studentcentered learning. Templates for constructing syllabi, lesson plans, lecture
schedules and novel ways to appeal to a wide variety of learning styles will be
provided. Opportunities will be given to develop and present sample lectures on
Regenerative Medicine. Special attention will be given to help build individual
strategies for applying for college and university faculty positions increasing future
employment options.
Prerequisite: Graduate degree
GENL 319
MCAT Review
This is a review course that prepares students for the Medical College Admission
Test (MCAT) given by the American Medical College Application Service. For
a description of who should take the MCAT and whether or not you meet the
requirements for taking the MCAT, please visit www.aamc.org. If you have not
26
Immunology and Microbiology

will learn the application of immunologic principles to human disease. The
diseases covered in the course range from allergy to immune deficiency to clinical
immunology.
John F. Finerty, Chairperson

Suresh K. Arya
Ira Berkower
Scott K. Durum
Joshua M. Farber
B. J. Fowlkes
Cynthia I. Grossman
Robert H. Hall
Pierre A. Henkart
Howard Streicher
Jane Tang
IMMU 521
Molecular and Cellular Mechanisms
of Immunity I
IMMU 403
Fall, 2 credits
Basic Principles of Immunology

and Hypersensitivity
John F. Finerty
The objective of this course is to provide a comprehensive review of immunology.

The course will cover: the innate/natural immune system; the adaptive immune
system; cells and organs within the immune system; immunoglobulin structure,
function and gene re-arrangements; B and T lymphocyte ontogeny, maturation
and function; lymphocyte cell surface receptors; cell interaction and signaling;
types of immune responses; chemokine and cytokine activities; immunology of
infection; autoimmunity and hypersensitivity; cancer immunology.
B. J. Fowlkes
Pierre Henkart*
The objective of this course is to survey recent advances in basic immunology

for students who have already had a basic immunology course. It is a series of
lectures by NIH researchers covering structural aspects of immune receptors, cell
biology of lymphocytes, the genetic and biochemical basis of immune receptors
and effector molecules. The differentiation, function and homeostasis of T, B and
NK lymphocytes and their subsets are covered, along with antigen processing
and recognition by T cells. The course includes lectures on signal transduction by
immune receptors and regulation of immunologically important genes. The spring
semester course IMMU 522 is designed as a follow-up.
Prerequisite: A previous immunology course or working knowledge of basic
immunology.
IMMU 522
Spring, 2 credits
Molecular and Cellular Mechanisms

of Immunity II
Prerequisite: College degree.
IMMU 419
Fall, 2 credits
Fall, 2 credits, Alternate years, 2012
Vaccines 2012
Ira Berkower
Howard Streicher*
In the 200 years since Edward Jenner introduced vaccination to replace the older
less effective practice of variolation, vaccines have become the bargain basement
of medicine: cheap, safe, and effective. This course is designed to provide detailed
survey of modern vaccinology, beginning with an examination of the traditional
vaccines. The course will identify the factors that distinguish successful from failed
vaccines, integrating coverage of molecular and immunobiology with clinical and
public health questions and provide a detailed structure for understanding how
innovative vaccines are developed. This course will cover vaccine approaches to
infectious disease, cancer vaccines, and HIV and selected topics of current interest.
Knowledge of basic immunology or consent of the instructor is recommended.
IMMU 504
Allergy and Clinical Immunology
The objective of this course is to correlate basic immunopathologic mechanisms
and human disease states. The major emphasis will be on the understanding of
mechanisms by which immunologic effector systems prevent or produce clinical
disease. Each lecturer will focus on the immunologic events involved in selected
organs, diseases or types of immune responses. The course is designed to bridge
the gap between immunologic principles and the maintenance of human health
or disease states. It is aimed principally at students with graduate degrees in the
medical sciences (M.D., Ph.D., D.D.S, R.N.) although students with extensive
experience in immunology may find the medical applications rewarding. Students
Scott Durum*
Joshua Farber
The objective of this course is to survey recent advances in basic immunology

for students who have already had a basic immunology course. The course is
designed as a follow up to the Fall semester course IMMU 521. It is a series
of lectures by NIH researchers covering basic science and clinical aspects of
adaptive and innate immunity to viruses, parasites and bacteria. AIDS, primary
immune deficiencies, autoimmunity, allergy and asthma will be discussed. Lectures
on cytokines and their receptors will include interleukins, interferons, chemokines,
the TNF family, TGFs and virokines. Regional immune systems of the skin and
bowel will be discussed. Bone marrow transplantation and immunotherapy of
cancer will be covered.
Prerequisite: A previous immunology course or working knowledge of basic
immunology, IMMU 521 or equivalent.
MICR 211
Fall, 3 credits
Jane Tang
This course provides an overview of the microbial world the largest biodiversity
on earth. Identification and characterization of microorganisms will be discussed,
as well as their cellular structures, physiology and genetics. Also included are
topics in emerging diseases; infectious agents affecting humans, animals and
plants; bioterrorism, microbial ecosystems; and biotechnological applications such
as food production and bioremediation.
27
Immunology and Microbiology continued

MICR 317
Fall, 2 credits
Suresh K. Arya
This course provides an introduction to the molecular virology of virus infection and
progeny virus production and spread. It details molecular mechanisms of virus
entry, replication, transcription, translation, and propagation in the host. Starting
with the molecular structure of select viruses, the course will focus on strategies
used by various viruses for successful infection and propagation, including
molecular mechanism of host defense and its evasion by the viruses. Select
viruses important to human health (e.g., influenza virus, papillomavirus, HIV), will
be considered in some details, highlighting recent advances in the understanding
their biology and pathogenesis. The lectures will include discussion of current
strategies for vaccine development and viruses as vectors for gene transfer in
functional genomics and gene therapy.
New MICR 432

Human Virology
Prerequisites: college graduate, knowledge of biology or consent of the

instructor
Introduction to HIV/AIDS Research
MICR 418
Spring, 3 credits
Robert H. Hall
Emerging infectious pathogens are predators that exploit changes in human

biology, behavior, and the environment to overcome public health measures and
host defenses. Recent domestic examples include influenza, SARS, monkeypox,
bovine spongiform encephalopathy, and West Nile virus. Hospital-acquired
infections, usually multidrug resistant, take the lives of over 90,000 Americans
annually. Infectious disease persists as a global problem. Vaccine-preventable
diseases are-emerge in populations at both ends of the wealth spectrum, such
as tetanus or rabies among the worlds poorest children; measles or mumps
among vociferous conscientious objectors. In South American, dengue fever,
schistosomiasis, leishmaniasis, and persistent childhood diarrhea feature
prominently. In sub-Saharan Africa, co-infections and drug resistance increasingly
frustrate the struggle against malaria, tuberculosis, and HIV/AIDS. East Asia, the
recent origin of novel influenza viruses, SARS, and multidrug resistant gonorrhea,
is a particularly interesting nexus of economic transformation, societal upheaval,
and government policy. Additional complications include a arising pandemic of
hepatitis C, brutal epidemics of cholera, and the long-delayed eradication of polio.
Climate change carries important implications, most immediately by exacerbating
microbial attacks on food animals and arable crops upon which we depend for
survival.
Suresh K. Arya
This course will begin with the description of the diseases that turned out to be
caused by viruses, such as cancer and AIDS, from antiquity to the present. This
will lead into (the methods) of discovery of viruses, their general properties, mode
of infection and propagations, genetics and evolution, viral pathogenesis, and host
defense. This will be followed by consideration of the select viruses and diseases
they cause in organ systems, such as respiratory tract, nervous system, bloodborn infections, sexually transmitted infections.
MICR 527
Prerequisites: Background in Biochemistry/Molecular Biology and

Microbiology, or consent of the instructor.
Spring, 2 credits

Cynthia I. Grossman
HIV/AIDS remains one of the greatest research and public health challenges
facing our nation and the world. This three credit course is designed to provide
a complete overview of the spectrum of AIDS research being performed today.
Examples of topics to be covered by guest lecturers include: epidemiology,
social and behavioral science, virology and biochemistry of HIV; how HIV causes
disease; the current snapshot of the global epidemic; the discovery, development,
and evaluation of anti-HIV drugs and vaccines; and the design and implementation
of methods to prevent the spread of HIV. We will also examine the current scientific
and ethical issues facing AIDS research.
Prerequisites: Basic knowledge of cell biology and social science

research is recommended, but not required.
GENE 415
(See page 12)
MEDI 522
Neural-Immune Interaction in Health and Disease
(See page 35)
In this class, we will survey a wide range of pathogens whose emergence

relates to contemporary human, microbiological, and environmental factors. We
will see how microbes have overcome medical marvels that took 150 years to
develop. Case studies will track pathogens from isolated outbreaks to pandemicity.
Common themes founded in history will be developed from almost 50 examples of
todays emerging infectious diseases.
Prerequisites: Interest in the interface of science and medicine, and for credit
students, willingness to make one class presentation on an emerging infectious
disease chosen from a list. Students interested in acting as a TA, please email
instructor at:erginginfections@verizon.net
28
Languages
Clark Lum, Chairperson
Anamaria Banu
Nancy Jorgenson
Donna King
Maria Suarez Lissi
Clark K. L. Lum
CHIN 402
Chinese Literature II
Juana Roman Maqueira

Fran Miller
Yukiyo Moorman
Angela Rodriguez
Illie Tecuta
CHIN 101
Prerequisite: CHIN 401 or equivalent.
Fall, 3 credits
Clark K. L. Lum
Failure to re-register for the second semester could result in cancellation

of that semester due to low enrollment.
Intermediate Chinese
Clark K. L. Lum
This course is a continuation of CHIN 401.
This beginners course is an introduction to the fundamentals of the Chinese

language in reading, writing, and speaking.
CHIN 102
Spring, 3 credits
Spring, 3 credits
Clark K. L. Lum

ENGL 105
Fall, 3 credits
Fran Miller
This course is designed for those who have studied a large amount of English
grammar and vocabulary, but whose ability to understand and speak English is
limited. Emphasis on listening to natural American English and basic techniques of
modern conversation. Prepared and spontaneous oral presentations are required.
Discussion of American culture and customs.
Registration limited to 10 students
ENGL 108

CHIN 301
Fall, 3 credits
Practical Chinese
Clark K. L. Lum
A beginning course in Chinese literature, culture and philosophy.

Practical Chinese
Prerequisite: ENGL 105 or equivalent.
ENGL 205
Clark K. L. Lum
Fall, 3 credits
Nancy Jorgenson
Emphasis on the speaking and understanding of American English. Patterns and

structures are practiced in controlled exercises that lead to their spontaneous use
in conversation. Intensive reading (i.e., through study of short passages), as time
permits.

This course is a continuation of ENGL 105. Continued emphasis on improving oral

and aural fluency for those who have a firm knowledge of English grammar and
structures, but who have limited oral proficiency. Discussion of American culture
and customs.
Spring, 3 credits
CHIN 401
Fran Miller
CHIN 302
Fundamental English Conversation II
Spring, 3 credits
Fall, 3 credits
Clark K. L. Lum
Chinese literature, culture and philosophy.

ENGL 207
Intermediate English II
Spring, 3 credits
Nancy Jorgenson
Continued emphasis on comprehending and speaking American English in

a comfortable classroom setting. The focus is on learning authentic and useful
language and increasing vocabulary. Attention is also given to pronunciation
issues.

29
Languages continued
ENGL 302
Fall, 3 credits
Fran Miller
Advanced listening selections/conversations for English comprehension and

expression improvement. Vocabulary and idiomatic usage building. Emphasis
on effective oral expression through discussions, debates, improvisations on the
advanced level. American cultural topics discussed.
Prerequisite: ENGL 207 or permission of instructor.
Advanced English Conversation II
Spring, 3 credits
Fran Miller
This course is a continuation of ENGL 302. Continued emphasis on refinement

of aural and oral skills on the advanced level. Prepared and spontaneous oral
presentations are required. American cultural topics discussed.
ENGL 305
Fall, 3 credits
Fran Miller
Advanced grammatical forms and structures are taught. Usage and variety of
tenses, modals expressing degrees of necessity and certainty, other auxiliaries,
nouns, noun modification, quantifiers, adjective clauses and phrases are studied
thoroughly on the advanced level.
Advanced English Structure II
Donna King
Continuation of FRCH 101. Study of French grammar, pronunciation, and culture.

The course will build conversation and writing skills and expand basic vocabulary
to deal with situations in daily life.
(Text: Invitation au Monde Francophone, Thompson Heinle)
FRCH 201
Fall, 3 credits
Anamaria Banu
This course will help students develop a more fluent communication in French
through a thorough review and interactive practice of French language structures.
Reading and writing assignments held students develop analytical and critical
thinking skills. Internet and computer aided activities, as well as audio and video
assignments provide students with cultural knowledge and ensure continued
development of functional communication in French in the four skill areas: reading,
writing, listening, and speaking.
(Text: Controverses, L. Oukada, D. Bertrand, J.L. Solberg; Heinle 2011)
(Controverses Student Activities Manual)
Prerequisite: One year of French at university level or two years of high school
ITAL 101
Italian for Beginners I
Fall, 3 credits
Illie Tecuta
Introduction to elementary Italian grammar, with emphasis on conversation and

culture.
ENGL 306
French for Beginners II
Spring, 3 credits

ENGL 304
FRCH 102

Spring, 3 credits
Fran Miller
This course is a continuation of ENGL 305. Passive voice, adverb clauses and
phrases, noun clauses, direct and indirect speech, conditionals and subjunctive
are studied thoroughly on the advanced level.
ITAL 102
Italian for Beginners II
Spring, 3 credits
Illie Tecuta
Continued study of Italian grammar and conversation.
Prerequisite: ITAL 101 or equivalent.

FRCH 101
Fall, 3 credits
Donna King
An introductory French course emphasizing oral and written communication,

pronunciation, the basic structure of the language, and French culture. The
course is designed for beginners and students with some knowledge of French
(Text: Invitation au Monde Francophone, Thompson Heinle).
30
JAPN 101
Fall, 3 credits
Yuki Moorman
An Introductory course in Japanese language and culture. Focus on the useful
oral communication, basic grammatical structure, and the Japanese writing
system are introduced. Use emails and chat sites for reading, writing and
listening exercise along with conventional textbook. Section of anime and movies
are used for conversation practice and cultural understanding.
JAPN 102
Introduction to Japanese II
Spring, 3 credits
Yuki Moorman
Continuation of JAPN 101.

Prerequisite: JAPN 101 or equivalent.
JAPN 203
Intermediate Japanese I
Continued study of basic sentence patterns and their use in oral communication
and simple writing. Reading comprehension and vocabulary building are also
emphasized. 80 basic Kanji are introduced.
JAPN 204
Intermediate Japanese II
JAPN 407
Advanced Japanese III
Vocabulary expansion, reading comprehension, and discussion of cultural and
cross-cultural topics. This course is conducted in Japanese.
JAPN 408
Advanced Japanese IV
SPAN 101
Fall, 3 credits
Angela Rodriguez
Introduction to basic structures and vocabulary with emphasis on the development

of oral communication, pronunciation and listening comprehension skills. Narration
and description in the present tense are introduced. A complete audio program is
available to reinforce the material presented.
JAPN 305

Advanced Japanese I
Intermediate to advanced grammar, vocabulary expansion and reading
comprehension. Discussion of cultural and cross-cultural topics.
JAPN 306
Advanced Japanese II
SPAN 102
Spanish for Beginners II
Spring, 3 credits
Angela Rodriguez
Continuation of SPAN 101. Presentation and role-play situations are included to

reach a higher proficiency level. Narration in the past is introduced.
Prerequisite: SPAN 101 or equivalent. Audio program is available.
SPAN 203
Fall, 3 credits
Juana Roman Maquiera
Continuation of SPAN 102. This course continues to stress oral communication,

listening comprehension and writing skills to reach a higher proficiency level. It
includes conversation, role-play situations, short compositions, reading and
discussion of supplementary materials. Intensive study and practice of the
intermediate levels of grammar, proceeding to the reading of material of medium
difficulty.
Prerequisite: SPAN 102 or equivalent.
31
Languages continued
SPAN 204
Intermediate Spanish II
Spring, 3 credits
Juana Roman Maquiera
Continuation of SPAN 203. Oral communication, listening comprehension and

writing skills are expanded through reading and discussion of selected Spanish
newspapers and magazine articles. Oral presentations and written reports are
required to reach an intermediate level of oral proficiency. Intensive study and
practice of more advanced levels of grammar, proceeding to the reading of
material of higher difficulty.
Prerequisite: SPAN 203 or equivalent.
SPAN 208
Spanish for Health Care Providers
Spring, 3 credits
Maria Suarez Lissi
This course is aimed to improve communication skills with Spanish-speaking

patients, building competence in interviewing, examining and treating them. It
includes conversation, role-play situations in the context of different common
medical situations, listening comprehension and discussion of supplementary
materials regarding Latino culture and its influence in healthcare decisions.
32
Mathematics, Statistics & Epidemiology

Paul D. Sorlie, Chairperson
Ghideon Ghebregiorgis
Henry S. Hsu
H. M. James Hung
Jacqueline Major
Reza Momenan
STAT 317
Kushang V. Patel
Yves Rosenberg
Deven Shah
Fatma Shebl
Sue-Jane Wang
MATH 127
Elementary Calculus I
Fall, 3 credits
Reza Momenan
This course is an introduction to calculus and is aimed at students who have not
taken calculus in their previous education. The course will begin with a review of
precalculus topics including graphing, functions and algebra which are then used
as the groundwork for exploring the core topics of limits, continuity, differentiation
and integration. Where possible, problems considered in class will be of a
biological nature and problem sets will be available to promote understanding.
Together with MATH 128, this course may satisfy the minimum requirement of
medical and dental schools.
Required textbook: Calculus for Biology and Medicine, 2nd edition, Claudia
Neuhauser
Prerequisites: Knowledge of trigonometry, basic algebra and graphing are
required
MATH 128
Elementary Calculus II
Spring, 3 credits
Reza Momenan
This is a continuation of MATH 127. Topics will include application of integration to

life sciences. Differential equations, functions of many variables, partial derivatives,
constrained and unconstrained optimization.
STAT 200
Introduction to
Experimental Statistics

Ghideon Ghebregiorgis*
Henry S. Hsu
This course introduces the statistical concepts and methods as applied to

the data encountered in biomedical and behavioral sciences. It emphasizes
the basic skills of experimental design, quantitative analysis of data and
statistical inferences. Topics covered in the first semester include: probability
theory and distributions; population parameters and their sample estimates;
descriptive statistics for central tendency and dispersion; hypothesis testing
and confidence intervals for means, variances and proportions. Topics covered
in the second semester include: the chi-square statistic and categorical data
analysis; linear correlation and regression model; one- and two-way analysis
of variance with multiple comparisons; analysis of covariance; nonparametric
methods; survival analysis. This course is designed for health science
researchers and clinicians who have little or no previous statistics courses.
Some mathematical background is required; working knowledge of algebra
preferred. Material covered in the first semester is necessary to satisfactorily
undertake the second semester; researchers with statistics literacy, who would
like to continue from where most beginning statistical courses end, can join the
second semester to extend the scope of their knowledge of advanced methods.
Fall, 3 credits
Kushang G. Patel
The objective of this course is to provide an introduction to the principles

and methods of epidemiology, defined as the study of the distribution and
determinants of disease frequency in man. Lectures, problem sets, and outside
reading will cover ecologic, case-control, cohort and experimental studies. Topics
to be discussed will also include issues in study design, measures of risk and
disease frequency, sources of bias, methods of controlling for extraneous factors,
principles of screening, and interpretation of data. Illustrations include classic
and contemporary studies of acute and chronic disease. Satisfactory completion
of this course permits students to apply for transfer of credits into the George
Washington University Master of Public Health Program.
Audience: This course is intended for anyone interested in the principles and
methods of epidemiology.
Course objective: To provide an introduction to the principles and methods
of epidemiology, defined as the study of the distribution and determinants of
disease frequency in man.
Prerequisites: STAT 200, or STAT 500 or equivalent.
STAT 318
Spring, 3 credits, Alternate years 2013
H. M. James Hung*
Sue-Jane Wang
The objective of this course is to learn more about the statistical methods used
in epidemiologic research. Particular emphasis is given to the analysis of data
derived from case-control and cohort studies. Procedures for adjusting for effect
modifiers and confounding factors, in log linear models and life table methods are
discussed.
STAT 321
Fall, 3 credits
Yves Rosenberg
The objective of this course is to learn the concepts and methodology used in the
design and conduct of randomized clinical trials. Topics to be covered will include
a description of the main types of trial designs, principles of randomization and
stratification, issues in protocol development (defining objectives and endpoints,
blinding, choice of control), recruitment and retention, data collection and quality
control issues, monitoring, and analyses of trials reports. Textbook material will
be supplemented frequently by material from the literature. Guest lecturers will
give lectures on power and sample size calculations, life table analysis, quality
of life and cost evaluation. Examples from the cardiovascular, pulmonary and
cancer areas will be used when appropriate. The course is intended for biomedical
researchers desiring exposure to the clinical trial area.
Prerequisite: STAT 500 or equivalent, or consent of the instructor.
STAT 322
Spring, 3 credits
Fatma Shebl
The objective of this course is to provide advanced training in the principles

of epidemiology. The course is designed to be a continuation of STAT 317 as
pertains to case control, cohort and experimental studies. Topics to be covered
33
Mathematics, Statistics & Epidemiology continued

include sample size estimation, interval estimation for odds ratio and relative
risk, attributable risk, direct and indirect standardization, and regression methods
for controlling for extraneous variables. The regression methods will include an
introduction to both regular linear and logistic regression. Instruction will include
lecture, in-class laboratory project and homework assignments. Access to SAS
(Statistical Analysis System) or comparable software, e.g. SPSS or STATA, is
required. Lectures will include instruction in SAS and most homework will require
computer analysis using statistical software.
Prerequisites: STAT 200, or STAT 500 or equivalent and STAT 317
New
STAT 435
Fall, 3 credits
Jacqueline Major
This course surveys the epidemiological approaches used to uncover genetic risk
factors for common diseases. Students should completed introductory courses
in epidemiology and biostatistics. No genetics is required, but background
in biological sciences will be helpful. The course will focus on the design and
implementation of genetic epidemiology studies for application in basic research,
diagnostics and pharmacogenetics. We will explore concepts of inheritance and
molecular genetics; evidence for genetic component in disease; family-based and
case-control study designs for finding genes associated with disease; analytical
concepts such as haplotype determination, linkage disequilibrium, population
stratification and gene-environment interaction and interpretation of the literature.
We will be discussing these and many other issues surrounding this fascinating
and relatively young branch of epidemiology that is rapidly growing to bridge the
gap between epidemiological practice and genetic knowledge.
STAT 500
Deven Shah
The objective of this course is to provide an overview of statistics for biomedical

research workers and clinicians who are interested in interpretation of the
results of statistical analyses. A series of integrated lectures on analysis and
interpretation of medical research data. Emphasis is on ideas and understanding
rather than mechanics. Topics covered in the first semester include the foundation
of statistical logic and the most commonly encountered statistical procedures
in medical research. The second semester expands on the material covered in
the first semester by looking at assumptions, extensions, and alternatives for
common procedures. Those who will be routinely engaged in computing statistical
procedures should consider STAT 200. STAT 500 is a full-year course. Material
covered in the first semester is necessary to satisfactorily undertake the second
semester.
STAT 518
Categorical Data Analysis
H. M. James Hung*
Sue-Jane Wang
epidemiological data are emphasized. The interpretation of models and fits, rather
than mathematical details of computational procedures is emphasized.
Prerequisite: STAT 200, or STAT 500 or equivalent.
STAT 525
Nonparametric and Robust Methods
H. M. James Hung*
Sue-Jane Wang
This course covers statistical methodology without strict parametric model

assumptions. Exploratory data analysis; linear rank statistics; chi-square and
Kolmogorov-Smirnov goodness-of-fit tests; order statistics; nonparametric
analysis of variance; nonparametric confidence interval; robust estimation of
location and regression parameters.
Applications to biological, clinical, and epidemiological data are

emphasized. The theoretical motivation rather than theory, the
interpretation rather than details of computational procedures are
emphasized.
Prerequisite: STAT 200, or STAT 500, or equivalent.
STAT 529
Fall, 3 credits, Alternate years
H. M. James Hung*
Sue-Jane Wang
This course covers statistical methods for the analysis of censored time event
data. Topics include introduction to survival analysis and failure-time data; survival,
hazard, cumulative hazard function; failure time models; nonparametric methods,
product limit (Kaplan-Meier) estimator, Greenwoods formula; proportional hazards
(Cox) regression model; accelerated failure time model and rank regression;
graphical methods for survival distribution fitting and assessing goodness of fit.
The theoretical motivation and interpretation of computational procedures are
emphasized.
Prerequisite: STAT 200, or STAT 500, or equivalent.
BIOF 309
(See page 8)
BIOF 312
(See page 8)
BIOF 518
(See page 9)
BIOF 537
(See page 9)
This course covers statistical methods for the analysis of structured, counted data.
Topics include Poisson, multinomial, and product-multinomial sampling models;
exact and asymptotic chi-square and likelihood ratio tests; log-linear models for
cross-classified counted data, including models for data with ordinal categories;
data of repeated categorical response; logistic regression and generalized linear
models; and measures of association. Applications to biological, clinical, and
34
Medicine and Physiology

John Tisdale, Chairperson
Irwin Arias
Francesco S. Celi
William Gahl
John I. Gallin
Meral Gunay-Aygun
Joshua Hunsberger
Linda Kupfer
Frederick P. Ognibene
MEDI 303
Matthew Rittler
Laurie Shuman Moss
Marni N. Silverman
Srikumar Sinnarajah
Esther M. Sternberg
Kuei-Meng Wu
MEDI 211
Fall, 2 credits
Introduction to the Principles

of Endocrinology
Francesco S. Celi
The objective of this course is to provide the student with elementary knowledge
on the principles of endocrine physiology and pathophysiology. This is an
elementary course that presumes only a modest background in general biology
and general chemistry. Holders of a graduate degree in any area of vertebrate
biology are discouraged from enrolling. The course will describe problems that
the organism solves by means of hormones and deals with the biochemical
mechanisms by which the different families of hormones (peptides, steroids, and
tyrosine derivatives) are synthesized, stored, released, transported, act on their
target tissues, and are degraded.
MEDI 217
Human Physiology I: Neural,
Cardiovascular, Pulmonary,
Sensory, and Neonatal Systems
Fall, 2 credits
Srikumar Sinnarajah
Basic Human Physiology from an integrated function and a health and disease
perspective. The relationships between normal function and disease are
examined; the impact of history and physiological research on medicine and
physiology is discussed. No laboratory included.
Fall, 3 credits
Kuei-Meng Wu
The objective of this course is to provide an overview of Chinese Acupuncture

technology. The basic traditional Chinese medicine concepts on channels,
Yin/Yang, Zang/Fu, Chi/Xue and differential diagnosis will be introduced. The
course will focus on acupoint location. Acupoints to be covered belong to
traditional channels and will include approximately 360 points. The proposed
therapeutical uses of the major acupoints will be discussed based on previous
human experience. World Health Organizations coding system will be used for
the acupoints names. Strategy for acupoint selection, point location workshop,
and tours/visits to a local acupuncture clinic may be given to enhance the above
learning objectives.
The Maryland Board of Acupuncture has indicated award of 48 hours of
Oriental Medicine CE credits to Acupuncture Practitioners.
Prerequisite: Basic knowledge of physiology and anatomy.
Joshua Hunsberger
And Guest Lecturers
This course is designed for individuals, clinicians, and research professionals

interested in basic concepts of regenerative medicine and its applications in
research, diagnostics, and the treatment of diseases. Lecture topics will include
basic concepts of regenerative medicine, cell therapy with embryonic and various
adult stem cells including induced pluripotent stem cells, tissue engineering,
gene therapy, clinical translation, regulatory implications, ethical considerations
and future possibilities/limitations. Each lecture will provide a complete overview
progressing from key concepts to practical applications. Faculty for this course
include staff clinicians/scientists and postdoctoral fellows.
MEDI 316
Biology of Cancer
This course introduces the student to important and timely concepts in Cancer
Biology. Initial lectures will focus on the hallmarks of cancer, basic terminology,
and the profile of cancer cell, as well as a discussion on the causes of cancer
including genetics, infectious agents (viruses) and environmental/chemical/
radiation exposure. Subsequent lectures will focus on the mechanisms of cancer
including an overview of oncogenes and tumor suppressors, cell control by signal
transduction pathways and their role in cancer, discussing the role of cell cycle,
cell death/survival pathways and DNA damage and check-point/DNA repair. The
course will also include lectures on rapidly evolving topics such as understanding
the tumor microenvironment, current models for studying cancer, miRNAs and
their role in cancer, epigenetic control of the cell, current opinions on cancer stem
cells, and the rationale behind cancer treatments.
MEDI 326
Prerequisites: Introductory biology and general chemistry.
MEDI 302
Regenerative Medicine: Considering

Applications and Treatments
Fall, 2 credits
Spring, 2 credits
Linda Kupfer
and Guest Lecturers
Global Health has been described as an area for study, research and practice
that places a priority on improving health and achieving equity in health for all
people worldwide (Koplan J, 2009. Lancet. 373:1993). Within the course, a
broad snapshot of global health will be presented, providing students with
insight into the challenges currently facing global health. Participants will also
gain an understanding of why tackling global health issues is such an important
endeavor with the potential to reduce poverty, build stronger economies and
promote peace. Students will not only be exposed to the major communicable
and non-communicable diseases posing a profound effect on health (especially
within the developing world) but will also discover how socio-economic and
demographic differences can influence the burden of disease. A number of
other critical underlying factors including environmental, behavioral and cultural
influences will also be presented. Through the use of case reports from around
the world, the course will also explore how research findings are transferred into
policy and practice. Students will be encouraged to understand that solving global
health problems requires the input of multiple disciplines. To emphasize this
point, speakers will be drawn from multiple fields including the sciences, ethics
economics and diplomacy.
35
Medicine and Physiology continued

MEDI 329
Fall, 2 credits
Advanced Topics in Cancer:

Tumor Microenvironment and Metastasis
Matthew Rittler*
Laurie Shuman Moss
This is a 14 week starter course that will cover the initiation and progression
of cancer, focusing on the tumor microenvironment and metastasis. Topics will
include primary tumor growth, the metastatic process, secondary tumor growth,
epithelial to mesenchymal transition, adhesion , and angiogenesis. This course
will also have a journal club component, which will enable students to read and
present a scientific journal article related to the course.
Note: Advanced does not refer to the difficulty of the course, but rather the more
specific topics covered in the course. The material presented is for all background
levels.
MEDI 507
Inborn Errors of Metabolism
William Gahl*
Meral Gunay-Aygun
The objective of this course is to learn the principles and practice of human
biochemical genetics. Students will research a topic and present the lectures. The
faculty will add to the class by offering experience, and when possible, presenting
individual cases. Topics to be covered include amino acidopathies, organic
acidoses, disorders of carbohydrate metabolism and lipid metabolism, lysosomal
storage diseases, peroxisomal diseases, purine and pyrimidine disorders, and a
variety of other inborn errors of metabolism. Several quizzes are planned and
student participation will be strongly encouraged.
This is an advanced course, largely geared toward PhDs and MDs.
Prerequisite: Graduate degree
MEDI 522
Neural-Immune Interactions
in Health and Disease
Spring, 2 credits
Marni N. Silverman*
Esther M. Sternberg
This newly recognized discipline studies interactions between the immune and
nervous systems at all levels from molecular and cellular to neuroanatomical,
neuroendocrine, behavioral and clinical. The course will cover molecular aspects
of these interactions, including neural and immune mediators and their receptors,
which may be members of the same superfamily or may regulate each others
expression or function. The course will also cover mechanisms and effects
of interactions between cytokines, neuropeptides and neurotransmitters. An
important focus will be the physiological role of cytokines expressed within the
brain and the pathological consequences of their over-expression in the CNS. The
course will also cover mechanisms by which peripheral cytokines signal the brain,
via transport across the blood brain barrier and second messenger signaling. It
will address the physiological effects of peripheral cytokines signaling the CNS,
and the pathophysiological consequences of disruptions or perturbations of
these communications on expression of autoimmune/inflammatory and infectious
diseases. The course will also cover non-hormonal, sympathetic, parasympathetic
and peripheral nerve mechanisms of communication between the nervous and
immune systems, and the pathophysiological effects of these communications.
Also covered will be aspects of human clinical conditions in which these
communications play a role: illnesses of the stress response; the effects of stress
36
on infectious and inflammatory disease; autoimmune/inflammatory diseases

in which disruptions of these communications play a role; effects of female sex
hormones on these interactions; social and behavioral factors which can influence
disease outcome through these mechanisms; restorative activities and their
effects through these interactions on stress-induced illnesses.
MEDI 550
Introduction to the Principles and
Practice of Clinical Research
Frederick P. Ognibene
John I. Gallin
and Guest Lectures
Registration and further information visit website:

http://www.cc.nih.gov/training/training/ippcr.html
The objective of this course is to provide an overview of the principles and practice
of clinical research to individuals who are interested in learning how to effectively
conduct clinical research studies. The course is divided into modules and contains
information on ethical, legal, scientific, regulatory, biostatistical and other practical
issues important the conduct of in clinical research. The format consists of didactic
lectures, practical experiences, such as a mock Institutional Review Board (IRB),
and case studies. To view the topics from last years curriculum, please go to the
course syllabus/schedule at: http://www.cc.nih.gov/training/training/ippcr/info.html.
MEDI 552
Demystifying Medicine for PhD Students,
Fellows and Staff
Spring, 2 credits
Irwin M. Arias
The goal of this novel course is to demystify medicine primarily, but not exclusively,
for PhD scientists through clinical presentations, analysis of the pathobiology
of major human diseases and bridging this information with advances in basic
biology. Clinician students, fellows and staff are also encouraged to participate.
Participants will interview selected patients, see pathologic specimens and
learn about major current diagnostic and therapeutic procedures. The class
will be heterogeneous in composition. The teaching staff will include clinicians,
pathologists and basic scientists. Three preview and two additional supplemental
lectures are being offered outside of the regularly scheduled semester. The course
is based on a highly successful venture conducted at Tufts University School of
Medicine for the past 19 years and for the past four years at NIH. To receive
academic credit for this course the student must register with FAES, pay tuition,
attend the sessions and complete a final takehome exam. Those wishing to audit
this course, can register directly with the instructor by email with no tuition charge.
BIOF 502
(See page 9)
MEDICAL SUBSPECIALTY
REVIEW COURSES
A series of review courses covering textbook material with special emphasis on
recent developments. These courses are designed specifically as preparation for
forthcoming Subspecialty Board Examinations.
MEDI 723
A Review of Endocrinology:
Diagnosis and Treatment
BIOF 552
(See page 10)
September 13 17, 2011
Lee Weinstein
and Guest Lecturers
The objective of this course is to provide an up-to-date, state-of-the-art review

of clinical endocrinology, emphasizing pathophysiology, diagnosis and treatment.
The course is intended both for physicians who are preparing for the Endocrinology
Subspecialty Board Examination and for physicians certified in endocrinology who
wish to remain abreast of recent advances.
The course objectives are twofold: To encourage an organized, efficient and costeffective approach to the clinical, laboratory and radiologic diagnosis of endocrine
disease, with emphasis on recent advances; and, to stimulate awareness of new
approaches to treatment, including the indications, risks and benefits relative to
alternative therapies.
Please write or call 301-496-7975 for a detailed schedule and tuition costs.
MEDI 725
November 11 & 12, 2011
Psychopharmacology and Neuroscience

Course: Update 2011
Guest Lecturers
The objective of this course is to provide practicing psychiatrists, senior residents,

and other interested professionals with a comprehensive update of recent
clinical and preclinical advances in the drug treatment of mental disorders. The
course objectives are three-fold: To review preclinical concepts regarding the
mechanism of action of psychopharmacologic agents; to present advances in
clinical psychopharmacology including new drug development and new treatment
approaches; and to integrate basic and clinical neuroscience into a comprehensive
framework which enables optimal clinical psychopharmacologic techniques.
Participants will receive a syllabus containing lecture outline material and references.
Continental breakfast and buffet lunches are included in the registration fee.
Please write or call 301-496-7975 for a detailed schedule and tuition costs.
37
Board Examination Review Courses

GENL 319
(See Page 26)
MCAT-Review
GENE 500
(See Page 12)
GENE 514
(See page 13)
Current Topics in Clinical Molecular Genetics and
Molecular Diagnostics
GENE 644
(See page 13)
Review of Medical Genetics
MEDI 723
(See page 37)
A Review of Endocrinology Diagnosis and Treatment
MEDI 725
(See page 37)
Psychopharmacology and Neuroscience Course:
Update 2011
Please check website www.faes.org for courses offering CME
38
Pharmacology and Toxicology

also provides an introduction to common pharmacokinetic and pharmacodynamic
modeling approaches. September 1-December 15, 2011
Frank Pucino, Chairperson

Chhanda Dutta
Sam Dutta
Juan Lertora
Fredric Lombardo
Robert Mitkus
Arvind K.N. Nandedkar
Frank Pucino
Kuei-Meng Wu
Robert S. K. Young
Prerequisite: Calculus.
Spring - This course includes the topics of drug transport mechanisms and
their relevance in pharmacokinetics and drug metabolism, dose response and
concentration response analysis, biological markers of drug effect, and adverse
drug reactions. In addition, emphasis is given to optimizing and evaluating the
clinical use of drugs, as well as drug therapy in special populations (children,
elderly adults, pregnant and nursing women). A special course module focuses on
the processes of drug discovery and development, and the regulatory role of the
FDA. January 5 April 26, 2012.
PHAR 359
Spring, 3 credits
Pharmacology of Chinese Herbs
Kuei-Meng Wu
The objective of this course is to provide a modern and alternative pharmacological

view of traditional Chinese herbology. The lectures on the prototypic Chinese
medicinal herbs will be arranged and delivered according to standard Traditional
Chinese Medicine (TCM) therapeutic categories. Both modern pharmacology and
TCM concepts will be used as the theoretical basis for the discussions. The major
emphasis of this course will be focused primarily on TCM safety and efficacy profile
of prototypic herbs, and currently known major active ingredients of selective herbs
in the formulation and their pharmacology/toxicology.
The Maryland Board of Acupuncture will award 48 hours of Oriental Medicine
CE Credits to Acupuncture practitioners.
Prerequisite: Basic Knowledge in Physiology and/or Pharmacology.
Prerequisite: PHAR 500 (fall semester) and Calculus
PHAR 511
Current Concepts in Pharmacology
and Therapeutics
Spring, 3 credits
Fredrick Lombardo
Frank Pucino*
This course is intended to provide instruction in current pharmacologic principles

of drug use, and their role in the diagnoses, prevention and treatment of disease.
Theoretical and practical issues of pharmacology will be discussed to assist
practitioners with therapeutic selection, use and evaluation of drug therapy.
Pharmacogenomic, pharmacokinetics and pharmacodynamic concepts will be
emphasized for many of the major pharmacologic classes of drugs used in clinical
medicine. The lecture material will be reinforced through case presentations and
student participation.
This is an elective for the Technology Transfer Certification Program.
PHAR 400
Year, 3 credits each semester, Alternate Year, 2013-2014
Pharmacology
Chhanda Dutta
S.N. Dutta
Robert S. K. Young*
The objective of this course is to present the pharmacological basis of therapeutics

by discussion of the principles of drug action and the mechanism of action
of representative agents. The initial portion of the course will be devoted to an
exploration of concepts such as pharmacokinetics, drug metabolism, doseresponse relationships, and resistance, and toxicity. Subsequent portions of the
course will focus on the chemistry, mechanism of action and pharmacologic action
of drugs affecting the autonomic and central nervous systems, the cardiovascular,
and renal systems, pathogenic microbes, cancer and hormones. A review of the
relevant physiology of each organ system will be presented.
PHAR 500
Principles of Clinical Pharmacology I & II
Juan Lertora
and Guest Lecturers
TOXI 303
Fall, 2 credits
Robert Mitkus
Toxicology is the study of the adverse effects of chemical, physical, or biological

agents on living organisms and the ecosystem, including the prevention and
amelioration of such effects. This course introduces the student to the general
principles of toxicology, various classes of toxic agents, and the organ and
biochemical systems that these agents affect. The student will be able to use
the information presented in the course to better understand and explain events
of human and companion animal toxicity that are reported in the media. A
great course for those contemplating graduate study in the fields of toxicology or
pharmacology, for those who work with toxicologists in a regulatory or research
setting, or for the layperson interested in learning more about toxicology. The
course will be augmented with talks by guest experts from time to time.
Prerequisite: College level biology and chemistry
Required Textbook: Casarett and Doulls Essentials of Toxicology (2nd ed. 2010)
Thursdays 6:30-7:45 pm
Tuition: $290 per semester
Fall - This course provides a basis for understanding the scientific principles
of rational drug therapy and contemporary drug development, with emphasis
on pharmacokinetics, methods for drug analysis, drug metabolism, and
pharmacogenetics. Topics include the physiologic and pathophysiologic
factors involved in drug absorption, distribution, metabolism and elimination,
determinants of variability in drug responses, inter- and intra-patient variability
in pharmacokinetics and pharmacodynamics, and drug interactions. This course
39
Pharmacology and Toxicology continued

TOXI 504
Toxicology: Principles and Practice
Spring, 3 credits
Fred Lombardo
Arvind K.N. Nandedkar*
The objective of this course is to provide a survey of general topics in toxicology

including but not limited to: pertinent experimental designs; factors altering
toxicity; environmental toxicology; risk assessment; occupational, pesticide,
drug toxicology; carcinogenesis, mutagenesis, and teratogenesis; mechanisms
of toxicity; target organ toxicology, clinical toxicology, evidence based forensic
toxicology and entrepreneurship concepts in the practice of toxicology. The
students should learn to appreciate the breadth and principles of toxicology; read
and understand articles on toxic effects; evaluate significance results of toxicity
testing and apply principles of toxicology in a practical setting.
COURSE WILL BE HELD AT HOWARD UNIVERSITY.
Prerequisite: College level biology and chemistry
40
Certificate of Public Health Program

Th F
The
Foundation
d ti ffor Ad
Advanced
d Ed
Education
ti iin th
the S
Sciences
i
(FAES)
Graduate School at NIH created a new Department of Public Health
in 2010 and is offering a Certificate in Public Health educational
program.
University policy (usually between 6 and 12 credit hours). For students

who have already completed some of these courses, such credits can
be applied towards the Certificate Program. Successful completion of the
Certificate Program requires a 3.00 GPA.
The overall goals of the Certificate in Public Health Program are to give
professionals an overview of and build competencies in the five core
disciplines of public health (as defined by the Association of Schools of
Public Health (ASPH) (http://www.asph.org/userfiles/version2.3.pdf) -epidemiology, biostatistics, environmental health sciences, health policy
and management, and social and behavioral sciences. In addition, students
will demonstrate their understanding of this core disciplinary knowledge
and practice by conducting a Capstone Project. Upon completion of this
program, a graduate will be able to:
EPIDEMIOLOGY
Epidemiology is the study of patterns of disease and injury in human
populations and the application of this study to the control of health
problems. (http://www.asph.org/userfiles/version2.3.pdf, page 10)
apply statistical reasoning and methods to address, analyze and solve

problems in public health; health care; and biomedical clinical and
population-based research
describe and explain patterns of disease and injury in human
populations and apply this study to the control of health problems
describe and understand environmental factors including biological,
physical and chemical factors that affect the health of a community
describe and explain factors that affect the delivery, quality and costs
of health care for individuals and populations; understand from a
managerial and policy perspective the structure, process and outcomes
of health services including the costs, financing, organization, outcomes
and accessibility of care
describe and explain behavioral, social and cultural factors related
to individual and population health and health disparities over the life
course; understand how programs and policies in public health and
health services promote and sustain healthy environments and healthy
lives for individuals and populations
With this broadened perspective, graduates of this education program will
be able to apply the principles, practices, and methods of public health to
their current positions or pursue careers in public health.
General Requirements:
The Certificate Program will be open to anyone with a Bachelors degree.
Courses are offered in the evenings, making them convenient for working
professionals and Postgraduate Fellows interested in learning about
public health, adding expertise and experience to enhance their current
employment position, or contemplating a public health career (see http://
www.101careersinpublichealth.com/). Students who wish to receive the
Certification are required to complete a curriculum comprised of one
full year of statistics (one two-semester course totaling 6 credit hours)
and one 3 credit hour course in each of the other four core disciplines,
epidemiology, health policy and management, social and behavioral
sciences, and environmental health sciences, plus a practicum/final
independent capstone project of 3 credits (total Certification requirement
21 credit hours). For students who have already completed some of these
courses, such credits can be applied towards the Certificate Program.
Successful completion of the Certificate Program requires a 3.00 GPA.
For most students, this Certificate Program is intended to be completed
within two to three years. Students interested in pursuing a Masters
of Public Health degree at an accredited University (see: http://www.
whatispublichealth.org/faqs/index.html) are responsible for contacting the
University to determine how many, if any, credits could be transferred under
BIOSTATISTICS
Biostatistics is the development and application of statistical reasoning
and methods in addressing, analyzing and solving problems in public
health; health care; and biomedical, clinical and population-based
research. (http://www.asph.org/userfiles/version2.3.pdf, page 10)
HEALTH POLICY AND MANAGEMENT
Health policy and management is a multidisciplinary field of inquiry and
practice concerned with the delivery, quality and costs of health care for
individuals and populations. This definition assumes both a managerial
and a policy concern with the structure, process and outcomes of health
services including the costs, financing, organization, outcomes and
accessibility of care. (http://www.asph.org/userfiles/version2.3.pdf,
page 10)
SOCIAL AND BEHAVIORAL SCIENCES
The social and behavioral sciences in public health address the behavioral,
social and cultural factors related to individual and population health and
health disparities over the life course. Research and practice in this area
contributes to the development, administration and evaluation of programs
and policies in public health and health services to promote and sustain
healthy environments and healthy lives for individuals and populations.
(http://www.asph.org/userfiles/version2.3.pdf, page 10)
ENVIRONMENTAL HEALTH SCIENCES
Environmental health sciences represent the study of environmental
factors including biological, physical and chemical factors that affect the
health of a community. (http://www.asph.org/userfiles/version2.3.pdf,
page 10).
Required Courses:
PBHL/STAT 317 - Introduction to Epidemiology (offered by the Department
of Mathematics, Epidemiology and Statistics) - Using lectures, problem
sets, and outside reading, this course provides an introduction to the
principles and methods of epidemiology, defined as the study of the
distribution and determinants of disease frequency in man.
PBHL/STAT 500 - Statistics for Biomedical Scientists (Year course)
(offered by the Department of Mathematics, Epidemiology and Statistics)
- The objective of this course is to provide an overview of statistics for
biomedical researchers, clinicians, and students in public health who
are interested in the interpretation of results of statistical analyses. This
course uses a series of integrated lectures on analysis and interpretation
of medical and public health research data. Emphasis is on ideas and
understanding rather than on mechanics. Topics covered in the first
semester include the foundation of statistical logic and the most commonly
encountered statistical procedures in medical and public health research.
41
Certificate of Public Health Program continued

PBHL 501 - Environmental Health Sciences - Environmental health
addresses human health effects of exposure to chemical, physical, and
biological agents in the community, workplace, and home. Activities
within environmental health sciences are associated with recognizing,
assessing, understanding, and mitigating the impacts of chemical,
physical, and biological agents as well as understanding how human
behavior and action impacts the environment. The environmental health
field is a broad, multidisciplinary field. This course focuses on the central
concepts, principles, issues, and applications of the essential scientific
components and strategies of understanding and controlling major
environmental health problems.
PBHL 512 - Social and Behavioral Sciences - The social and behavioral
sciences in public health address the behavioral, social and cultural
factors related to individual and population health and health disparities
over the life course. Research and practice in this area contributes to the
development, administration and evaluation of programs and policies
in public health and health services to promote and sustain healthy
environments and healthy lives for individuals and populations.
CORE COURSES OFFERED IN THE FALL SEMESTER

PBHL/STAT 317 Introduction to Epidemiology
PBHL/STAT 500 Statistics for Biomedical Scientists I
PBHL 517 Health Policy and Management
PBHL 607 Capstone Project in Public Health
CORE COURSES OFFERED IN THE SPRING SEMESTER
PBHL/STAT 500 Statistics for Biomedical Scientists II
PBHL 501 Environmental Health Sciences
PBHL 512 Social and Behavioral Sciences
PBHL 607 Capstone Project in Public Health
PBHL 517 - Health Policy and Management - Health policy and

management is a multidisciplinary field of inquiry and practice concerned
with the delivery, quality and costs of health care for individuals and
populations. This definition assumes both a managerial and a policy
concern with the structure, process and outcomes of health services
including the costs, financing, organization, outcomes and accessibility
of care.
PBHL 607 - Capstone Project in Public Health - The Capstone Project is
a mentored course. The student will be required to spend approximately
one day per week for the duration of the semester at an appropriate
professional office to put classroom learning into practice. When students
apply for the Capstone Project, to be conducted after completing all
five core courses listed above, they must first determine which public
health competencies (See course learning objective under Department
of Public Health course descriptions) they wish to develop further during
the mentored experience. Then students must submit plans worked out
with the mentor for achieving these objectives during the project to the
Department Chair for approval.
42
Public Health
Stephen E. Marcus, Chairperson
David A. Broniatowski
Paula Goodwin
Chris Hafner-Eaton
Harry T. Kwon
Margaret A. McDowell
David E. Nelson
John Parascandola
Sarah M. Pope
PBHL 507
Communicating Science to Lay Audiences
Courses offered by the Department of Public Health are open to all

students enrolled in the Certificate of Public Health Program as well as
interested students not enrolled in the Certificate Program. (Courses
required for Certificate Program include: PBHL/STAT 317, PBHL/STAT
500, PBHL 501, PBHL 512, PBHL 517 and PBHL 607.)
PBHL 501
New
Semester and instructor TBA, 3 credits
Environmental Health Sciences

Environmental health addresses human health effects of exposure to
chemical, physical, and biological agents in the community, workplace,
and home. Activities within environmental health sciences are associated
with recognizing, assessing, understanding, and mitigating the impacts of
chemical, physical, and biological agents as well as understanding how
human behavior and action impacts the environment. The environmental
health field is a broad, multidisciplinary field. This course focuses on the
central concepts, principles, issues, and applications of the essential
scientific components and strategies of understanding and controlling
major environmental health problems.
Course Learning Objectives: Upon completion a student will be able
to
1. Describe the direct and indirect human, ecological and safety effects
of major environmental and occupational agents.
2. Describe genetic, physiologic and psychosocial factors that affect
susceptibility to adverse health outcomes following exposure to
environmental hazards.
3. Describe federal and state regulatory programs, guidelines and
authorities that control environmental health issues.
4. Specify current environmental risk assessment methods.
5. Specify approaches for assessing, preventing and controlling
environmental hazards that pose risks to human health and safety.
6. Explain the general mechanisms of toxicity in eliciting a toxic response
to various environmental exposures.
7. Discuss various risk management and risk communication
approaches in relation to issues of environmental justice and equity.
8. Develop a testable model of environmental insult.
Fall, 2 credits
Harry T. Kwon
David E. Nelson
Communicating scientific information, including data, to the public,

members of the news media, and policy makers is increasingly becoming
an important responsibility of scientists and health practitioners especially
in this era of the Internet and the growing problem of information overload.
Science communication can be challenging for many reasons.
This course will cover a broad range of topics directly relevant to
communicating science, health, and medicine to lay audiences. Among
the topics will be audience analysis and other basics of communication
(including lay health beliefs, mathematical and scientific literacy);
psychological processes; ethics; using the OPT-In model to select and
present data as part of the entire communication process; and visual and
narrative presentations. The course will also cover specialized topics such
as risk communication; communicating science for advocacy; and acute
or crisis communication. A major emphasis of this course will on practical
recommendations for improving the communication of science and data
to lay audiences.
New
PBHL 511
Fall, 2 credits
Introduction to
Margaret A. McDowell
Applied Public Nutrition
Strategies to Improve Population Health
This course will introduce the student to the concepts and principles
of public health nutrition. Emphasis will be on population health and
the methods, policies, and strategies to assess and alleviate diet-related
chronic diseases. A socio-ecological framework will be used to explore
the societal, economic, environmental, and institutional barriers to optimal
nutritional status and health among diverse populations. Case studies will
be used to illustrate innovative strategies, policies, and programs that have
been developed to improve the nutritional status of diverse communities.
The course will be conducted in a seminar style and will include readings,
guest lectures, web-based activities, and interactive discussion.
PBHL 512
Social and Behavioral Sciences
Spring, 3 credits
Paula Goodwin
The social and behavioral sciences in public health address the

behavioral, social and cultural factors related to individual and population
health and health disparities over the life course. Research and practice
in this area contributes to the development, administration and evaluation
of programs and policies in public health and health services to promote
and sustain healthy environments and healthy lives for individuals and
populations.
to
1. Identify basic theories, concepts and models from a range of social
and behavioral disciplines that are used in public health research and
practice.
2. Identify the causes of social and behavioral factors that affect health of
individuals and populations.
3. Identify individual, organizational and community concerns, assets,
resources and deficits for social and behavioral science interventions.
43
Public Health continued

4. Identify critical stakeholders for the planning, implementation and
evaluation of public health programs, policies and interventions.
5. Describe steps and procedures for the planning, implementation and
evaluation of public health programs, policies and interventions.
6. Describe the role of social and community factors in both the onset
and solution of public health problems.
7. Describe the merits of social and behavioral science interventions and
policies.
8. Apply evidence-based approaches in the development and evaluation
of social and behavioral science interventions.
9. Apply ethical principles to public health program planning,
implementation and evaluation.
10. Specify multiple targets and levels of intervention for social and
behavioral science programs and/or policies.
New
PBHL 517
Health Policy and Management
Fall, 3 credits
PBHL 519
Health Disparities
Paula Goodwin
The major goal of this course is to enable students to critically analyze

historical, economic, social, cultural, political, and environmental factors
that have contributed to health disparities for racial/ethnic minority
populations and other health disparity populations (e.g., poor and rural
populations) in the United States. Students will critically exam existing
literature and theoretical frameworks related to social determinants of
health, discuss the mechanisms through which social factors influence
health, and review various intervention approaches for reducing health
disparities.
New
PBHL 5xx
Semester TBA, 3 credits
Public Health in Historical Perspective
John Parascandola
Chris Hafner-Eaton
Health policy and management is a multidisciplinary field of inquiry

and practice concerned with the delivery, quality and costs of health care
for individuals and populations. This definition assumes both a managerial
and a policy concern with the structure, process and outcomes of health
services including the costs, financing, organization, outcomes and
accessibility of care.
to
1. Identify the main components and issues of the organization, financing
and delivery of health services and public health systems in the US.
2. Describe the legal and ethical bases for public health and health
services.
3. Explain methods of ensuring community health safety and
preparedness.
4. Discuss the policy process for improving the health status of
populations.
5. Apply the principles of program planning, development, budgeting,
management and evaluation in organizational and community
initiatives.
6. Apply principles of strategic planning and marketing to public health.
7. Apply quality and performance improvement concepts to address
organizational performance issues.
8. Apply systems thinking for resolving organizational problems.
9. Communicate health policy and management issues using appropriate
channels and technologies.
10. Demonstrate leadership skills for building partnerships.
44
New
An examination of the development of public health and its impact

on society from ancient times to the present. The course will focus on
public health in the Western world, with some attention also given to a
broader international perspective. Public health developments will be
viewed within a broader societal context, demonstrating how social,
cultural, political and economic factors, as well as scientific and medical
ones, shape public health policy. The perspective that history can shed on
current health issues will also be considered.
New
PBHL 5xx
Ethics in Public Health
Semester TBA, 3 credits

Sarah M. Pope
One basic principle that the field of public health is based on is that
every person has the right to a standard of living adequate for the health
and well-being of himself and his family (Article 25 of the Universal
Declaration of Human Rights). This course will explore historic and
contemporary ethical issues raised in public health. Upon completing this
course, students will be able to identify and critically analyze key ethical
dilemmas and the relevant stakeholders in public health while exploring
the societal, cultural, religious, and moral values that influence the ethical
decision-making process.
New
PBHL 602
Complexity, Flexibility and

Systems Thinking
Spring, 3 credits
David A. Broniatowski
Introduces core theory of systems thinking, with contextual applications

in public health. Focus on doctoral-level analysis of scholarship on key
concepts such as system boundary definition, complexity, uncertainty,
fragility, and robustness, as well as a critical look at the historical roots of the
field and related areas such as engineering systems, systems dynamics,
agent modeling, systems simulations and abstraction. Contextual
applications are drawn from ongoing and cutting-edge research in the
field of public health. Special attention is given to the interdependence of
social and technical dimensions of complex systems.
New
PBHL 607
Fall Repeated in the Spring, 3 credits
Capstone Project in Public Health
Stephen E. Marcus
The Capstone Project is a mentored course. The student will be

required to spend approximately one day per week for the duration of
the semester at an appropriate professional office to put classroom
learning into practice. When students apply for the Capstone Project,
to be conducted after completing courses in all five core public health
disciplines, they must first determine which public health competencies
(listed under the five core course learning objectives) they wish to develop
further during the mentored experience and submit plans worked out
with the mentor for achieving these objectives during the project to the
Department Chair.
Learning Objectives: The student along with the mentor will
determine an appropriate project to demonstrate mastery of selected
core competencies. Examples of potential projects include: 1) designing,
conducting, and analyzing data from an original research or evaluation
study; 2) conducting secondary data analysis of existing data; 3)
conducting a policy or regulatory analysis; 4) performing administrative or
managerial functions within the health care delivery system; 5) developing
an outreach or community-based health program; or 6) working on an
educational or health campaign for a professional association, nonprofit
association, or advocacy group
PBHL/MICR 418
(See page 28)
PBHL/MEDI 326
(See page 35)
PBHL/STAT 318
(See page 33)
PBHL/STAT 321
(See page 33)
Methodology in Clinical Trials.
PBHL/STAT 322
(See page 33)
PBHL/STAT 500
(See page 34)
PBHL/TECH 512
(See page 49)
Global Bioethics for Scientists and Administrators
PBHL/TECH 586
(See Page 52)
International Science Technology and Innovation Policy
PBHL/TOXI 303
(See page 39)
45
Certificate in Technology Transfer

Introduction:
The relatively new field of Technology Transfer can trace its origins and rapid
growth to the economic developments and legislation of the early 1980s,
a time when the US was looking to enhance its global competitiveness.
While countries like Germany and Japan were exceptionally good at
translating the ideas that originated from academic labs into useful
products, US academic research results were by and large relegated to
mere publications in scholarly journals. Concerned about the non-use
of this potential goldmine of ideas, the US lawmakers passed a series of
legislation in the early 1980s culminating in the famous Bayh-Dole Act.
This Act has shifted the onus of commercialization from a central granting
agency to the numerous grantees that receive the research funds, and
the grantees have taken very enthusiastically to this shift. The Economist
has lauded this Bill as the most inspired piece of legislation in the last half
century.
The National Institutes of Health has always been a leader in health
research. After the 1980s legislations, the NIH has led the nation in
technology transfer as well, having spawned from its research, the
development of a number of lifesaving drugs, vaccines and medical
devices (www.ott.nih.gov). Both the research scientists and technology
transfer professionals at NIH have been responsible in making sure that
basic results in the lab get successfully transplanted to the marketplace
as useful biomedical products.
What is technology transfer and what are the career opportunities in the
field? What are the skills required and how does one acquire them?
Answers to these and other questions can be found on a number of
informative websites like www.autm.net, www.federallabs.org, www.lesi.
org etc. The technology transfer profession employs more than 10,000
professionals in the US with a fairly large number practicing their trade in
the greater Washington DC area. We hope that the Certificate program
in Technology Transfer will serve not only the needs of scientists and
engineers who wish to pursue this non-traditional career, but also those
of professionals who seek additional training. The course instructors are
all respected practitioners of the field. Through this Certificate Program,
students can simultaneously gain the necessary knowledge and build
professional networks.
General Requirements:
The Certificate Program will be open to anyone with a degree in Science
or Engineering, and may be completed in approximately 2 years. Courses
are offered in the evenings, making it convenient for working professionals
and Post-doctoral Fellows contemplating non-traditional careers.
Students who wish to receive the Certification will be required to take a
total of 15 credit units, with 12 units of in-class coursework, and a final
independent project of 3 units. The required courses include: TECH 513,
TECH 565, and TECH 607. The elective courses include: TECH 512,
TECH 521, TECH 566, TECH 567, TECH 572, TECH 575, TECH 576,
TECH 579, TECH 584, TECH 592, TECH 501,TECH 503, TECH 504,
CHEM 327, PHAR 511 and MEDI 552. For students who have already
completed some of these courses, such credits can be applied towards
the Certificate. At the end of all the coursework, students can receive the
Certificate by contacting Ms. Audrey Lyons, the Registrar of the Graduate
School.
46
Upon completion of the Certificate, students may also transfer the

entire 15 credits as a block into any of four M.S. degree programs at the
University of Maryland University Colleges (UMUC) Graduate School of
Management and Technology. See the Regulations and Procedures
section of this catalog for more details.
Required Courses:
TECH 513- Introduction to Technology Transfer- An introductory course
that covers the history of the field and provides an overview of patenting,
licensing, collaborative agreements and other fundamental intellectual
property transactions.
TECH 565- Biomedical Business Development for Scientists- A practical
hands-on course intended to expose students to the concepts of business
planning, venture capital, technology transactions and commercialization.
TECH 607- Capstone Course in Technology Transfer- Through this
mentored course, the student would be required to spend approximately
one day per week for the duration of the semester at an appropriate
professional office where they would put some of their classroom learning
into practice.
Elective Courses:
TECH 501 Inside and Outside the FDA This course provides an
introduction to various elements and strategies used in navigating FDA
regulatory requirements with a perspective from both inside the FDA and
inside industry to FDA regulations.
TECH 503 Business Law Primer for Life Science Entrepreneurs This
course provides the student with a working practical knowledge of certain
essential substantive areas of the law and the ability to select, work with
and use lawyers effectively.
TECH 504 FDA Regulatory, Industry, and Hidden Intellectual Property
This course provides a deeper exploration of how FDA regulation shapes
business decisions inside of industry as well as the cost-analysis that
industry used to make regulatory decisions and the intellectual property
that is generated in-house throughout the product life.
TECH 512 Global Bioethics for Scientists and Administrators - The
purpose of this interdisciplinary course is to conduct ethical analyses of
a cluster of cutting edge issues in order to understand the human values
and policy issues at stake.
TECH 521 Tools for Technology Transfer- This course will focus on the
nuts and bolts of technology transfer. A team of NIH technology transfer
professionals will focus on the various types of agreements, contracts and
collaboration mechanisms used in the field and address potential issues
or problems that one may encounter when negotiating the agreements.
TECH 566 Biotechnology Business Leadership and Management
Strategies- Through on-site visits, review of company literature and
lectures, the students will study the strategies and management of various
life science companies. A number of managerial functions such as senior
management, finance, R&D, manufacturing, marketing and human
resources will be examined and each student will be required to present a
summary of their findings and recommendations.
TECH 567 International Strategic Partnering and Business

Development- This course will teach the students to take an international
perspective when dealing with various aspects of globalization in life
science research and product development. Policy, financing, distribution
and other aspects of the global war on disease prevention and eradication
will also be discussed.
TECH 572 Marketing Strategies for Scientific Organizations- This
course will explore the critical role played by marketing in the success of
science-based organizations. In addition to exploring the basic concepts
of marketing, the course will cover the unique challenges faced by
technology transfer professionals.
TECH 575 Business Finance and Accounting Principles for ScientistsIntroduction - An overview course on how companies keep score and
understand the financial health of their organizations. Financial and cost
accounting principles and other analytical tools will be taught to equip the
student to understand how financial variables would impact the contracts
that are negotiated.
TECH 576 Topics in Business Management for Scientists This course
will cover topics typically taught in a college business programs, including
topics in financial analysis and strategies, economics, strategic planning,
contract law and marketing strategies, as well as fundamentals of
investment and personal finance.
TECH 579 Negotiation Workshop- Through this course, students will
gain valuable insight into the negotiation process by applying theories from
instructional readings to in-class negotiation exercises and discussion.
The course will offer a comprehensive approach to negotiations with
lessons derived from the Harvard Negotiation Project, and examples
derived from students work and home experiences.
TECH 582 Intellectual Property and Patent Prosecution for Scientists
This course will provide a general review of intellectual property with a
special focus on patents. Beginning with the invention stage, the course
will discuss the various steps of obtaining, defending and utilizing patents.
TECH 584 Medical Product Development- This course will explore
the marketing and regulatory process by which a bioscience product
is developed and brought to commercialization. Topics will include the
product development process, regulatory challenges and how they impact
R&D, manufacturing and marketing, intellectual property and financial
issues, and finally some product development case studies.
TECH 587 Strategic Planning for Life Science Companies:

Transformational Growth and Implications Organization, Process and
Technology This course explores the necessary process and framework
needed to develop a growth strategy that will create breakthrough results
for life science companies.
TECH 592 Public-Private Partnerships An overview of how
partnerships are established between diverse elements of the private and
public sectors, and what motivates, drives and sustains such relationships.
TECH 501 Inside and Outside the FDA This course provides an
introduction to various elements and strategies used in navigating FDA
regulatory requirements with a perspective from both inside the FDA and
inside industry to FDA regulations.
TECH 503 Law, Contracts and Ethics in the Pursuit of Science An
overview of basic business, legal , ethical and regulatory concepts that
impact a scientists work. Practical issues such as drafting various types
of contract will be discussed. How best to deal with ethical, legal and
regulatory considerations that impact scientific research will also be
covered.
TECH 504 FDA Regulation, Industry, and Hidden Intellectual Property
This course provides a deeper exploration of how FDA regulation shapes
business decisions inside of industry as well as the cost-analysis that
industry uses to make regulatory decisions and the intellectual property
that is generated in-house throughout the product life cycle.
CHEM 327 The Art of Drug Design and Discovery- The course
will explore the fundamental principles of modern drug discovery by
discussing the latest methods in molecular modeling, high throughput
screening, structure-activity relationships, high resolution study of targets
and other rational drug design principles.
PHAR 511 Current Concepts in Pharmacology and Therapeutics- This
course covers the current pharmacologic principles of drug use, and their
role in the diagnoses, prevention and treatment of disease through a
combination of lectures, case presentations and student participation.
MEDI 552 Demystifying Medicine for PhD Students, Fellows and StaffThe goal of this course is to bridge the gap between basic and clinical
researchers by demystifying medicine to the non-clinical audience. This is
accomplished through clinical presentations, analyzing the pathobiology
of major human diseases, and bridging this information with advances in
basic biology.
TECH 586 International Science, Technology and Innovation Policy

This course provides a comprehensive overview of the policy issues
related to support, use, management, and applications of science and
technology internationally.
47
Technology Transfer Certificate Program

Steven M
St
M. F
Ferguson, Ch
Chairperson
i
Susan Ano
Sabarni Chatterjee
Barry Datlof
Steven M. Ferguson
Yali Friedman
Bruce Goldstein
Lee Heiman
Rita Khanna
Tara Kirby
Barbara B. Mittleman

Preference will be given to students taking the course for credit toward a
certificate in Technology Transfer.
Julie Muroff
Frederick Provorny
Uri Reichman
Michael Salgaller
Luis A. Salicrup
Erika R. Smith
Brian R. Stanton
Rosemarie Truman
Jeff Walenta
Sury Vepa
*PLEASE NOTE: This is a new course title and description.
New
FDA Regulation, Industry, and

Hidden Intellectual Property
TECH 501
Inside and Outside the FDA
This course provides an introduction to various elements and strategies
used in navigating FDA regulatory requirements with a perspective
from both inside the FDA and inside industry to FDA regulations. It
explores the organization of the FDA, what is regulated by the FDA,
and how the FDA enforces those regulations. The course also covers
how the industry complies with the FDA, what happens when they do
not, and how compliance effects internal business decisions. In most
biotech organizations today, medical technology created is subject to
FDA regulation. This course will discuss the product life cycle, regulatory
requirements pre-market and post-market, and other elements of
compliance necessary for corporate success. Students will learn the role
the FDA plays in the development of new medical technologies and how
corporations big and small are affected.
This course is an elective for the Technology Transfer Certificate Program
TECH 503
Business Law Primer for
Life Science Entrepreneurs
Fall, 2 credits
Frederick Provorny
Sury Vepa
This course, intended for individuals looking to start or join a technology

company now or in the future, work in technology transfer, or pursue
any other technology-related occupation but lacking legal background,
seeks to provide an overview of and appreciation for contracts and
other important legal subjects and skills necessary to start and operate
a successful science and technology enterprise. This course provides
the student with a working practical knowledge of certain essential
substantive areas of the law and the ability to select, work with and use
lawyers effectively. The focus is on the real-world legal considerations in
forming and sustaining an innovative enterprise, reviews legal structures
for a new venture, intellectual property, employment law, contracts,
government regulation, and real and personal property. The course will
use current real-life examples and hands-on exercises. It is expected
that students completing this course will develop both a familiarity and
a working knowledge of different phases of an innovative enterprise,
including start-up phase to growth stage to exit strategies. This course
is thus designed to complement a would-be entrepreneur or science or
technology professional education background with practical applications
of contracts and other legal concepts.
48
TECH 504
This course provides a deeper exploration of how FDA regulation

shapes business decisions inside of industry as well as the cost-analysis
that industry uses to make regulatory decisions and the intellectual
property that is generated in-house throughout the product life cycle.
Students will learn innovative techniques for identifying and managing
potential synergies between FDA regulations and the development of
new intellectual property. This course introduces problems in scientific
and creative thinking which increases the quality of resolving product
development conflicts while helping to stimulate innovation. In most
organizations today, creative conflict management is no longer optional
its necessary for success. The course will discuss the interconnected
elements in the regulatory process that apply to the development of new
technologies and the regulatory hurdles that exist along the way. The
course will emphasize the role the FDA plays in the development of such
technologies and how intellectual property is generated throughout.
The course will also discuss strategies for identifying, optimizing, and
capitalizing on the IP collected throughout the product life.
Prerequisites: TECH 501 or permission of the instructor.
This is an elective for the Technology Transfer Certificate Program.
TECH 506
Fall & Spring, 1.5 credits
Researcher Commercialization
Steve Ferguson
Webinar Course: The Essentialsand the National
Center for Entrepreneurial Tech Transfer (NCET2)
This online webinar course is designed for researchers in research
institutions (e.g., grad students, post-docs, professional staff and
faculty) and researchers in commercial companies (e.g., startups, SBIRfunded firms, research-based small businesses and Global 1000). It
allows attendees to make an informed decision as to how to better plan
their commercialization efforts, be it through employment, licensing,
consulting, joint venturing, or startup creation. The course itself will deal
with successfully commercializing any type of research activity, whether
focused on engineering, physical sciences or life sciences, and not specific
to just NIH. The topics themselves will introduce the practical business and
legal issues that researchers need to understand to commercialize their
research. The course will start with the different ways to commercialize
research, ranging from the traditional (i.e., employment and licensing)
to the more entrepreneurial (i.e. consulting, joint venturing/strategic
alliance and startup company). It will show how these commercialization
methods overlap and how they differ. These sessions will also deal
with fundamental topics like intellectual property, licensing agreements,
employment agreements and consulting agreements, which researchers
must understand regardless of whether they intend to be researchers at a
university lab or the founder of the next great public company. The second
half of the course will give an introduction to the advance topics of creating
and funding companies. The main difference between the fundamental
and advance topics is that the fundamental are basically personal topics
that every researcher needs to know in their commercialization efforts. The
advance topics deal with commercializing as a group, with the resulting
complexities of understanding the relationships and expectations of the
other team members in the company, be they other employees, founders,
executives, board members, shareholders, investors or partners.
Each lecture is a 90-minute webinar that can be viewed live or off-line on
at www.ncet2.org. There will be expert guest speakers for each session.
FAES registration will be necessary only to take the course for academic
credit.
TECH 512
Spring, 2 credits (13 weeks)
Global Bioethics for Scientists

and Administrators
Gladys White
The birth of bioethics as a field of study is generally identified as a mid

20th century phenomenon that occurred largely within the United States.
But important issues of moral concern regarding the interface of humanity
and technology can only be meaningfully understood in a global context.
The purpose of this interdisciplinary course is to conduct ethical analyses
of a cluster of cutting edge issues in order to understand the human
values and policy issues at stake. Key topics will include: international
exchanges of tissues, organs and body parts, the creation of genetic
databases, public health ethics including management of communicable
disease, reproductive tourism, stem cell tourism, pharmaceuticals and
the developing world, nanotechnology, environmental issues including
consideration of animal rights, and sport ethics. Each class or two
will be based on at least one important controversy and debate will be
encouraged.
TECH 513
Introduction to Technology Transfer
Spring, 2 credits
Susan Ano
Steven M. Ferguson*
This introductory is aimed at both scientists as well as technology transfer

professionals. Specific topics will include: the history, legislation and
public policy that drive federal technology transfer; the role of the Office
of Technology Transfer at NIH; the role of the Technology Development
Coordinators at NIH; forms of intellectual property; the definition of
a patentable invention and the definition of an inventor; the patent
application process; licensing of inventions; patent litigation; infringement
and interference; collaborative research; and transactional agreements.
Federal, state, international, academic, and small and large industrial
perspectives will be explored. Special topics will include biomedical
technology development, third party considerations in natural products
development, and technology assistance programs.
TECH 521
Fall, 2 credits
Bruce Goldstein
Designed for technology transfer specialists new to the field or scientists

and other individuals wanting to learn the nuts and bolts of technology
transfer activities, this course will delve into the day-to-day tools utilized by
professionals in the field in some detail. The course will begin with setting
the context with an introduction to intellectual property law and then will
turn to a focused review of the various types of agreements relating to
collaborations, exchanges of materials, license agreements, and clinical
trials along with the potential issues or problems they are designed to
address. Finally, the field of technology transfer will be put into a broader
context with a look at its relationship to contracts, grants, and other forms
of government / non-government interactions plus customer-service
techniques and negotiation tactics (including specific class exercises, as
time permits).
Prerequisites: TECH 513 Introduction to Technology Transfer is recommended
but not required.
TECH 565
Biomedical Business Development
for Scientists
Fall, 2 credits
Steve Ferguson*
Michael Salgaller
Jeff Walenta
This course will take a practical, hands-on approach to business plan

development, venture capital and technology transactions. Using current
examples from the active technology portfolio of the NIH Office of
Technology Transfer, or an example of their own choosing, students will
learn and participate in reviewing a scientific innovation and determining
whether the discovery makes a realistic business proposal. The course
will look at the history of venture capital and its relation to science and
technology. The course will emphasize technology transfer issues
(particularly, from an NIH standpoint) related to real world technology
partnerships and venture capital investments. Issues related to legal
considerations including due diligence and licensing issues will also be
highlighted. The course will be taught as a semester-long simulation in
which students take on the various roles of entrepreneurs and investors
in all aspects of science focused on venture capital dealings. Lectures by
seasoned biotechnology CEOs and venture investors will provide for a
real world approach to learning. Students will be expected to develop
a draft business plan by the end of the semester. Student plans may be
selected for use in marketing or commercialization efforts by the NIH
Office of Technology Transfer.
Prerequisites: Basic or advance knowledge of science. No business credits
required.
This course is required for the Technology Transfer Certificate Program.
This course is required for the Technology Transfer Certificate Program.

49
Technology Transfer continued

TECH 566
Biotechnology Business Leadership and
Management Strategies
Spring, 2 credits
Steve Ferguson
Yali Friedman*
Jeff Walenta
This course will take a practical, hands-on approach to study the strategies
and management of biotechnology and biomedical firms. There will be
a review of specific businesses and their development, funding options
(financial markets, venture capital etc.) and technology transactions
(including royalty arrangements and strategic partnering). Focus will be
on critical thinking and management/human capital decisions during
times of conflict and growth. Senior management and scientists will
offer their individual stories about their operational challenges. The
course will include onsite visits and lectures relating to various sized
biotechnology companies in the region. Students will critically review
company annual reports and business write-ups as background prior to
these presentations and visits. Firms chosen to understand operational
perspectives will include companies from a wide variety of biomedical
business sectors: medical devices, laboratory reagents, diagnostics,
drug discovery, pharmaceuticals and service providers. A wide variety of
managerial functions within these organizations will be examined, such
as senior management, human resources, finance, R&D, marketing and
manufacturing. Students will provide oral presentations after such visits
and engage in group discussions on the issues identified and potential
solutions to business/science problems. The students will provide written
feed back to the management of these companies that summarize their
discussions.
Prerequisites: Basic or advanced knowledge of science. TECH 565 helpful,
but not required. No business credit required.
TECH 567
International Strategic Partnering and
Business Development
Fall, 2 credits

Prerequisites: Basic or advanced knowledge of science. No business credits
required.
TECH 572
Marketing Strategies for Scientific
Organizations
Spring, 2 credits
Barry Datlof
This course explores the role of marketing in science based organizations

that seek to reach their goals in technology development, product
development, public health impact or other societal needs. The course
will start with a clarification of what constitutes marketing by providing the
students with the basic concepts, terminology and practices of marketing.
Next, the course will focus on the role of marketing in a research or
scientific organization and the specific issues related to marketing
technologies. Using a case study approach, students will be provided with
examples of market analyses in the biomedical area and how to conduct
them. The students will use real world examples of technologies to create
an effective marketing strategy with details of administering specific
marketing programs. Additional topics will include socially responsible
marketing and marketing technologies in international markets, specifically
in developing countries.
Rita Khanna
This course will take a practical look at the growing global market place for
innovative biomedical products and research with a focus on the business
planning, market development, venture capital, technology transactions,
and relevant international partnerships. Using current examples from the
active global portfolio of NIH or other organizations, the students will be
able to compare activities coming out of US and foreign countries to learn
and to review scientific innovation and to determine whether a particular
discovery constitutes a realistic business proposal from an international
perspective.
This course seeks to understand international S&T cooperation. It also
seeks to understand the dynamics of U.S. foreign policy, especially
where cooperative S&T is used as an important tool in promoting U.S.
international health, economy, and trade objectives. Case studies will be
featured. Topics include: definition of international S&T cooperation, its
past and present applications; U.S. strategic objectives associated with
it; and the major forms and types of international agreements particularly
those involving NIH. The course will look at the history of international
50
venture capital and its relation to science and technology. The course will
emphasize technology transfer issues related to the new world royalty
structures, technology partnerships and venture capital investments.
Students will be expected to assess a technology of their choice, and
develop a draft executive summary of a new bio business concept with
potential commercial advantage in the international market place or write
a research paper on one of the topics covered. Such student efforts may
be selected for use in commercialization efforts by the NIH Office of
Technology Transfer, presentation to international business plan groups,
or for publishing in an international journal. The course will provide a
real world flavor by including lectures by seasoned scientists, CEOs,
investors and other executives that play major roles in international or
global markets.
Students (individually or in groups) will be asked to utilize the key marketing

concepts to develop a marketing plan for a biomedical technology, product
or service that maybe chosen from the technology portfolio of the NIH
Office of Technology Transfer (OTT) or based on concepts relevant for
other NIH functions. These marketing plans may then be further utilized
by OTT or other relevant NIH offices to support their organizational goals.
Prerequisites: Basic or advanced knowledge of science. No business credits
required
TECH 575
Fall, 2 credits
Business Finance and Accounting Principles

for Scientists - Introduction
Uri Reichman
Finance and accounting are the language of business, yet this language
is not well understood by people in non-profit or scientific research
institutions who work with for profit companies. This course will give an
overview of how companies keep score and how outsiders (like us) can
understand the financial health of their internal activities. The course
will make extensive use of financial statements (Annual and Quarterly
Reports) from companies well known by the class, and use these reports
to introduce principles of financial accounting. These principles will
be tied into an understanding of: (1) How an individual can assess the
financial stability and capabilities of a partner; (2) How financial issues
can impact potential collaborations and deals with companies; (3) How
financial issues directly impact agreements that class members may be
part of. The class will also look at the operation of financial markets and
how the reported financial issues of a company interact with the broader
financial markets. The understanding of financial markets may be of
personal relevance to the class participants.
Students will make extensive use of publicly available financial
information that may be found online. The class will have periodic out
of class assignments, and will provide an opportunity for students to
present their analysis in class.
Prerequisites: Experience with or interest in collaborations or agreements with
for profit organizations.
TECH 576
Topics in Business Management
For Scientists
Spring, 2 credits
Uri Reichman
Understanding of business concepts are essential to licensing

professionals, as licensing specialists interact with business organizations
and business people on a daily basis. This course will cover topics
typically taught in a college business programs, including topics in
financial analysis and strategies, economics, strategic planning, contract
law and marketing strategies, as well as fundamentals of investment and
personal finance.
Prerequisites: No particular prerequisites are required for this course. TECH
575 may be helpful but not necessary.
The objective of the Negotiation Workshop is to increase your

confidence in managing difficult relationships and conversations.
Specifically, the workshop will focus on: understanding basic models
of negotiation; planning for all phases of negotiation, including the
anticipation of common barriers; communicating with, and relating to, the
other participant(s) in the negotiation, including considerations of ethics
and culture; evaluating your strengths and weaknesses as a negotiator
and as a negotiating partner; and developing a plan for further learning
and improvement.
TECH 582
Intellectual Property and Patent
Prosecution for Scientists
Spring, 2 credits
Lee Heiman*
Brian Stanton
The course will provide a general review of the US intellectual property

system and a comprehensive analysis of its patent process. The attendee
will take a journey beginning with the definition of an Invention and how it
is conceived. Then a case study approach will permit the student to look at
the definition of a patent, what it can do, and how it is obtained. Using an
historical approach to account for social, economic, and technical changes,
the participants will gain greater knowledge of the history of the patent
system, the evolution of US patent law, the process of obtaining, defending,
and attacking patents, and review the many different ways that conflicts
involving intangible intellectual property (IP) can be resolved. IP has
emerged as a currency that connects our global community and the course
will also explore how one values a patented technology as well as the
factors, such as where the technology is in the research and development
pipeline and the effect of regulatory compliance, affects valuation. While
the course will focus on the US process, we will also explore the role of
the Patent Cooperation Treaty, the World Trade Organization, Import
and Export controls, dual-use technologies, and how patents can spur
innovation in both monetary and non-monetary ways. A small-team class
project will encompass (1) drafting a basic patent application addressed to
a technology chosen by each team and (2) a mock patent examination. At
the conclusion of the course, attendee should not only understand what a
patent is, but should also be able to comprehend the subtleties involved in
answering questions like Why is DNA patentable? Is it possible to patent
a human being? and why are some rocks potentially patentable! These
seemingly simple questions take on new dimensions when one combines
science, law, morality, and politics.
TECH 579
Fall, 2 credits
Julie A. Muroff
TECH 584
To succeed at work, and in life, you need to communicate and collaborate

with other people. These relationships require thoughtful and strategic
negotiations. While some people may seem to be born negotiators,
negotiation skills can be learned, studied and improved. The Negotiation
Workshop will help you think more critically and creatively about your
negotiations. You will gain valuable insight into the negotiation process
through this interactive course, which will incorporate instructional
readings and in-class negotiation exercises and discussions.
Spring, 2 credits
Sabarni Chatterjee
Tara Kirby
Erika R. Smith*
To be competitive in industry, scientists must understand the intricate

process of translating basic research into innovative, market driven
products. Further, these scientists must be able to navigate the complex
pathways of intellectual property management and the regulatory affairs of
agencies such as the FDA. This course will provide life sciences students
the skills to integrate industry-relevant training and experience with their
51
Technology Transfer continued

basic science education. This course will explore the licensing, marketing
and regulatory processes by which a bioscience product is developed and
brought to commercialization (formerly TECH 384)
New
TECH 586
International Science, Technology

and Innovation Policy
Spring, 2 credits
Luis A. Salicrup
This course provides a comprehensive overview of the policy issues

related to the support, use, management, and applications of science
and technology internationally. It addresses U.S. domestic as well as
international issues, is concerned with governmental policies as well
as non-governmental related innovation. Science and Technologybased innovation is now seen to be connected to economic growth and
development and its corresponding ability to generate societal well being.
This course will examine the public policy behind the federal government
role in the science and technology innovation system. Additionally, this
course will enhance those current and planning careers in and around
global science and technology with the adequate background for
involvement in science policymaking. International opportunities related
to collaborative research, training, capacity building and technology
transfer available at Federal agencies like NIH, NSF, CDC, FDA, DOE,
USAID, State Department: international organizations such as World
Health Organization, Pan American Health Organization, UNESCO,
UNICEF, United Nations Development Programme (UNDP), Doctors
without Borders as well as those international programs available at
professional societies like the National Academy American Association of
Clinical Oncologists (ASCO), American Public Health Association (APHA),
American Society of Microbiology (ASM), American Chemical Society
(ASC), American Society of Hematology (ASH), European Molecular
Biology Organization (EMBO), Biotechnology Industry Organization
(BIO), Association of University Managers (AUTM), etc and universities
in the United States, Europe, Asia, Latin America, Africa and the Middle
East.
New
TECH 587
Fall, 2 credits
Strategic Planning for Life Science

Rosemarie Truman
Companies: Transformational
Growth and Implications Organization, Process and
Technology
This course explores the necessary frameworks needed to develop
a growth strategy that will create breakthrough results for life sciences
companies. While many companies realize the need for strategic
planning, many do not understand how to plan for long-term growth,
which involves creating a new market and preparing the company for
breakthrough transformation. This course will emphasize the challenges,
risks and rewards associated transformational growth, as well as how to
appropriately respond to shifting dynamics within a company and across
industries. Students will assemble into small groups to construct individual
strategy plans. Each interactive course session will focus on a different
process of a 6-11 step methodology. By applying innovative techniques
to achieve growth breakthrough results and sustainability for a company,
students will be able to create a complete growth breakthrough strategy
plan by the end of the course.
52

Prerequisites: Basic or advanced knowledge of life sciences, TECH 565, 566
helpful but not required.
Enrollment preference will be given to students taking the course for credit
towards this certificate.
TECH 592
Spring, 2 credits
Public-Private Partnerships
Barbara B. Mittleman
Public-Private Partnerships (PPPs) represent a novel means for government

to leverage appropriated resources to accomplish more, faster, and better
work than when working alone. Private partners are diverse, even within
a sector, and include industry, private foundations and philanthropists, as
well as academic and research organizations. Each sector responds to
different drivers, uses different metrics for success and value, and works
under different business practices and policies. This course will address
motivations for PPPs; partnership structures to accomplish the stated goals
and objectives; what policies are needed to satisfy the partners and the
public; relevant legal authorities and policies that impinge on PPPs; and
provides an opportunity for both case studies and group work in modeling
PPPs. Faculty will include NIH PPP program staff as well as experts in
technology transfer, legal counsel and outside speakers.
TECH 607
Fall, 3 credits, Repeated in the Spring
Steve Ferguson*
Frederick Provorny
This course is designed as a final course in technology transfer for those

students seeking to complete the FAES Certificate in Technology Transfer.
With this course the students will utilize the information and experience
gained in their other technology transfer courses along with their scientific
training to complete an actual project at the NIH or in the regional
community relating to technology transfer.
This course is customarily taken after a student has completed at least
six previous courses in science or technology transfer and has compiled
a strong academic record. As part of the course, interested students must
have identified a research topic and a mentor who is familiar with their
prospective inquiry and who is willing to provide guidance and oversee the
project. Assistance is available to students in selecting a topic & locating
a mentor. The research project must be independent of current workrelated responsibilities as determined by the project mentor. The mentor
may be from the NIH, the local business community, a supervisor from
the students place of work, or any expert with appropriate credentials.
Students are required to submit a formal proposal for review and approval
by the course instructors. Students must meet with the course instructors
periodically to discuss the projects progress. A written document, poster
presentation or similar result must be completed and approved by the
course instructors and project mentor for the student to receive credit.
Prerequisites: Permission of the instructor.
This course may be taken two times once as a required course and once
as an elective towards fulfilling the course requirements of the Certificate in
Technology Transfer Program.
Faculty Biographies, Telephone Numbers and Email Addresses

Adelstein, Robert S., M.D., Harvard Medical School; Chief, Laboratory
of Molecular Cardiology, National Heart, Lung and Blood Institute,
National Institutes of Health. 301-496-1865. email: adelster@mail.nih.gov
Adhya, Sankar L., Ph.D., University of Wisconsin, Ph.D., University of
Calcutta; Section Head, Section of Developmental Genetics, Laboratory
of Molecular Biology, National Cancer Institute, National Institutes of
Health. 301-496-2495. email: sa4pa@nih.gov
Al-Naeeli, Mawadda, Ph.D., University of Rochester; Postdoctoral
Fellow, Molecular Cell Biology Section, Molecular Medicine Branch,
NIDDK, 301-496-2313. email:alnaeelim@mail.nih.gov
Ano, Susan, Ph.D., Emory University; Chief, Infectious Disease and
Medical Engineering Branch, Office of Technology Transfer, Office of the
Director. National Institutes of Health. 301-435-5515
Appella, Daniel, Ph.D., University of Wisconsin; Senior Investigator,
Laboratory of Bioorganic Chemistry, National Institute of Diabetes and
Digestive and Kidney Diseases, National Institutes of Health.
301-451-1052. email:appellad@mail.nih.gov
Arias, Irwin, M.D., State University of New York (Downstate); Senior
Scientist, National Institute of Child Health and Human Development,
and Assistant to the Director, Intramural Program, National Institutes of
Health. 301-402-8394. email: ariasi@mail.nih.gov
Arya, Suresh K., Ph.D., University of California, San Francisco;
Program Director and Adjunct Investigator, Developmental Therapeutics
Program, Division Cancer Treatment and Diagnosis, and Basic Research
Laboratory, Center for Cancer Research, National Cancer Institute,
National Institutes of Health. 301-496-8783.email:aryas@mail.nih.gov
Bale, Sherri J., Ph.D., University of Pittsburgh; Clinical Director,
GeneDx, Inc., Gaithersburg, Maryland. 301-519-2100 ext 6102.
email: sherrib@genedx.com
Barchi, Joseph J. Jr., Ph.D., University of Hawaii; NMR Facility Head,
Laboratory of Medicinal Chemistry, National Cancer Institute, Frederick
Cancer Research and Development Center. 301-846-5905.
email: barchi@helix.nih.gov
Berkower, Ira, M.D., Ph.D., Albert Einstein College of Medicine; Chief,
Laboratory of Immunoregulation, Office of Vaccine Research and
Regulation, Center for Biologics Evaluation Research, Food and Drug
Administration. 301-496-1870. email: berkower@cber.fda.gov
Biesecker, Barbara B., M.S., University of Michigan; Genetic Counselor
and Director, Genetic Counseling Program, Social and Behavioral
Research Branch, National Human Genome Research Institute, National
Institutes of Health. Adjunct Assistant Professor, Johns Hopkins
Bloomberg School of Public Health. 301-496-3979.
email: barbarab@nghri.nih.gov
Biesecker, Leslie G., M.D., University of Illinois College of Medicine;
Investigator, Genetic Diseases Research Branch, National Human
Genome Research Institute, National Institutes of Health. 301-402-2041.
email: leslieb@helix.nih.gov
Bhagwat, Medha, Ph.D., University of Maryland at College Park;
Informationist/Bioinformatics Specialist, National Institutes of Health
Library, National Institutes of Health. 301-496-2185. email: Bhagwat@
mail.nih.gov
Busby, Benjamin, Ph.D., University of Maryland at Baltimore; Postdoctoral Fellow, Evolutionary Genomics Research Group, National
Center for Biotechnology Information, National Library of Medicine,
National Institutes of Health. 301-594-2698.email:ben.busby@gmail.com
Cceres, Jos, M.M., University of Maryland, Pianist, teacher, master
class leader, adjudicator (private studio). 202-289-8353.
email:caceres@josecaceres.com
Celi, Francesco S., M.D., University of Rome La Sapienza, Rome,
Italy; Staff Clinician, Clinical Endocrinology Branch, National Institute
of Diabetes and Digestive and Kidney Diseases, National Institutes of
Health. 301-435-9267. email: fc93@nih.gov
Chatterjee, Sabarni, Ph.D., State University of New York, Binghamton;
Licensing and Patenting Associate, Office of Technology Transfer,
National Institutes of Health. 301-435-5587.
email: chatterjeesa@mail.nih.gov
Chernomordik, Leonid V., Ph.D., The A.N. Frumkin Institute of
Electrochemistry, Russian Academy of Sciences; Section Head, Senior
Investigator, Section on Membrane Biology, Laboratory of Cellular and
Molecular Biophysics, Eunice Kennedy Shriver National Institute of Child
Health and Human Development, National Institutes of Health.
301-594-1128. e-mail: lchern@helix.nih.gov
Chyatte, Jeffrey, DDS., University of Maryland, Professor of Anatomy
and Physiology, Montgomery College 301-650-1453,
email: Jeff.Chyatte@montgomerycollege.edu
Datlof, Barry, M.B.A., University of Chicago; Managing Partner,
Pregmama LLC. 301-332-2548. email:FAES@datlof.com
Davies, David, Ph.D., Oxford University; Section Chief, Laboratory
of Molecular Biology, National Institute of Diabetes and Digestive and
Kidney Diseases, National Institutes of Health. 301-496-4295.
email: david.davies@nih.gov.
Dogan Islamaj, Rezarta, Ph.D., University of Maryland at College
Park; Research Fellow, National Center for Biotechnology Information,
National Library of Medicine, National Institutes of Health. 301-435-8779.
email:Rezarta@gmail.com
Dong, Lijin, Ph.D., University of Pittsburgh; Staff Scientist, Genetic
Engineering Core, National Eye Institute, National Institutes of Health.
301-402-5296.email:dongl@nei.nih.gov
Durum, Scott K., Ph.D., Oak Ridge Associated Universities; Senior
Investigator, Laboratory of Molecular Immunoregulation, Frederick
Cancer Research Center, National Cancer Institute, National Institutes of
Health. 301-846-1545. email: durums@ncifcrf.gov
Dutta, Chhanda, Ph.D., Uniformed Services University of the Health
Sciences; Director, Musculoskeletal Research, Geriatric Program,
National Institute on Aging, National Institutes of Health. 301-435-3048.
email: cd232@nih.gov
Dutta, S.N., M.D., Calcutta University; Ph.D., Howard University; Food
and Drug Administration (retired)
53
Faculty Biographies, Telephone Numbers and Email Addresses continued

Espey, Michael G., Ph.D., Georgetown University; Staff Scientist,
Molecular and Clinical Nutrition Section, NIDDK. 301-402-6513.
email:SP@nih.gov
Epstein, Suzanne, Ph.D., Massachusetts Institute of Technology; Office
of Cellular, Tissue and Gene Therapies, Food and Drug Administration.
301-827-0450. email epsteinsue@gmail.com
Gallin, John I., M.D., Cornell University; Director, NIH Clinical Center;
Laboratory of Host Defenses, National Institute of Allergy and Infectious
Diseases, National Institutes of Health. 301-496-4114.
email: jig@cc.nih.gov
Eresian, Warren J., Ph.D., Pennsylvania State University;

email: warren.eresian@nist.gov
Gebert, Claudia, Ph.D., University of Veterinary Medicine Hannover,

Germany; Post-doctoral Fellow, Section on Genomic Imprinting Program
in Genomic Differentiation, Eunice Kennedy Shriver National Institute
of Child Health and Human Development, National Institutes of Health.
301-402-0676.email:gebertcl@mail.nih.gov
Farber, Joshua M., M.D., Johns Hopkins University; Investigator,

Laboratory of Clinical Investigation, National Institute of Allergy and
Infectious Diseases, National Institutes of Health. 301-402-4910.
email: joshua_farber@nih.gov
Gellert, Martin, Ph.D., Columbia University; Chief, Section on Metabolic

Enzymes, Laboratory of Molecular Biology, National Institute of Diabetes,
and Digestive and Kidney Diseases, National Institutes of Health.
301-496-5888. email: mg2m@nih.gov
Ferguson, Steven M., M.B.A., George Washington University; Director,

Deputy Director, Licensing and Entrepreneurship, Office of Technology
Transfer, National Institutes of Health. 301-435-5561.
email: sf8h@nih.gov
Ghebregiorgis, Ghideon, Ph.D., Center for Biologics, Evaluation and

Research, Food and Drug Administration. 301-827-6065.
email:Ghideon.ghebregiorgis@fda.hhs.gov
Finerty, John, Ph.D., Louisiana State University; Chief, Cellular

Immunology and Lymphoma Section, Cancer Immunology and
Hematology Branch, National Cancer Institute (retired), Chair,
Immunology and Microbiology Department, FAES Graduate School at
NIH. 301-253-6170. email: finertyj@verizon.net
Fontaine, Fanette, Ph.D., Universit Pierre et Marie Curie, Paris,
France; Postdoctoral Fellow, Environmental Gene Regulation Laboratory,
National Institute of Child Health and Human Development, National
Institutes of Health. 301-402-0532.
Fowlkes, B.J., Ph.D., George Washington University; Chief, T Cell
Development Section, Laboratory of Cellular and Molecular Immunology,
National Institute of Allergy and Infectious Diseases, National Institutes
of Health. 301-496-5530. email: bfowlkes@mail.nih.gov
Francis, Fouad, Ph.D., The City University of New York (CUNY);
Research Fellow, Pulmonary Care Medicine Branch, National Heart,
Lung and Blood Institute, National Institutes of Health. 301-402-7127.
email:francisf@nhlbi.nih.gov
Freedberg, Daron I., Ph.D., UCLA; Senior Scientist, Center for Biologics
and Evaluation and Research, Food and Drug Administration.
301-496-4684. email: daronfreedberg@nih.gov
Friedman, Yali, Ph.D., University of Buffalo; Managing Editor, Journal
of Commercial Biotechnology (Palgrave-MacMillian-UK), Founder and
Manager, Drug Patent Watch. email:info@thinkbiotech.com
Gahl, William A., M.D., Ph.D., University of Wisconsin, Madison; Head,
Section on Human Biochemical Medical Genetics Branch, National
Human Genome Research Institute, National Institutes of Health.
301-402-2739. email: bgahl@helix.nih.gov
54
Goldsmith, Paul K., Ph.D., University of Maryland; Head, Antibody

and Protein Purification Unit (APPU), Laboratory of Biosystems and
Cancer, Center for Cancer Research, National Cancer Institute, National
Institutes of Health. 301-496-1229. email: paulg@mail.nih.gov
Goldstein, Bruce D., J.D., Emory University School of Law, M.S.,
Johns Hopkins University; Technology Transfer Policy Specialist, Office
of Technology Transfer, National Institutes of Health. 301-435-5470.
email:goldsteb@mail.nih.gov
Goodwin, Paula Y., Ph.D., University of North Carolina at Greensboro;
Health Scientist Administrator, National Institute on Minority Health
and Health Disparities, National Institutes of Health, 301-402-1366.
email:goodwinpy@mail.nih.gov
Gunay-Aygun, Meral, M.D., Hacettepe University School of Medicine,
Ankara, Turkey; Staff Clinician, Medical Genetics Branch, National
Human Genome Research Institute, National Institutes of Health.
301-594-4181. email: mgaygun@mail.nih.gov
Gussman, Aaron, M.S., University of Virginia; Data Management
Specialist, NCBI. 301-451-6559.email:agussman@gmail.com
Hall, Robert H., Ph.D., University College, University of London, U.K.;
Microbiologist.301-451-5074. email: emerginginfections@verizon.net
Hart, P. Suzanne, Ph.D., Medical College of Virginia; Associate
Investigator, Director, Molecular Genetics Fellowship Program, National
Human Genome Research Institute, National Institutes of Health. 301594-6051. email: shart@mail.nih.gov
Heiman, Lee C., J.D., Loyola School of Law; Intellectual Property
Counsel, Offices of Lee C. Heiman. 240-432-0789.
email:lee.heiman@starpower.net
Henkart, Pierre A., Ph.D., Harvard University; Chief, Lymphocyte

Cytotoxicity Section, Experimental Immunology Branch, National Cancer
Institute, National Institutes of Health. 301-496-1554.
email: henkartp@mail.nih.gov
Kirk, Kenneth L., Ph.D., University of Wisconsin; Chief, Laboratory of

Bioorganic Chemistry, National Institute of Diabetes and Digestive and
email: kennethk@bdg8.niddk.nih.gov
Herkenham, Miles, Ph.D., Northeastern University; Laboratory Chief

and Section Chief, Section on Functional Neuroanatomy, National
Institute of Mental Health, National Institutes of Health.
email: mherkenham@comcast.net
Komlosh, Michal E., Ph.D., Massey University, Plmerston North, New

Zealand; Contractor, PPITS, National Institute of Child Health and
Human Development, National Institutes of Health. 240-620-9440.
email:komloshm@mail.nih.gov
Hinton, Deborah M., Ph.D., University of Illinois at Urbana-Champaign;

Chief, Gene Expression and Regulation Section, Laboratory of Molecular
and Cellular Biology, National Institute of Diabetes and Digestive and
e-mail: dhinton@helix.nih.gov
Krash, Jessica, DMA, University of Maryland at College Park;

Faculty (Associate Adjunct Professor) George Washington University,
Department of Music. 202-215-8666. email:jkrash@gwu.edu
Ho, Mitchell, Ph.D., University of Illinois at Urbana-Champaign; Chief,

Antibody Therapy Unit, Laboratory of Molecular Biology, National Cancer
Institute, National Institutes of Health. 301-451-8727.
email:homi@mail.nih.gov
Hsu, Henry S., Ph.D., MPH, University of Michigan; Division Director of
Biostatistics, Center for Biologics Evaluation and Research, Food and
Drug Administration. 301-827-6051. email: henry.hsu@fda.hhs.gov
Huang, Yang, Ph.D., Rutgers University; Research Fellow, Computational
Biology Branch, National Center for Biotechnology Information, National
Institutes of Health. 301-496-7202.email:huangyan@mail.nih.gov
Hung, H. M. James, Ph.D., Iowa State University; Mathematical
Statistician, Office of Biostatistics, Center for Drug Evaluation and
Research, Food and Drug Administration. 301-796-1092.
email: hsienming.hung@fda.hhs.gov
Hunsberger, Joshua, Ph.D., Yale University; Post Doctorate
IRTA, National Institute of Mental Health, National Institutes of
Health.301-496-7762.email:hunsbergerjg@gmail.com
Jorgenson, Nancy, B.A., University of North Dakota; ESL Instructor,
Montgomery County Refugee Training Program at Montgomery College.
301-251-1134. e-mail: nancyjorg@comcast.net
Khanna, Rita, J.D., University of Maryland, Ph.D., University of Illinois;
General Counsel, Aeras Global TB Vaccine Foundation. 301-547-2900.
email:Rkhanna@Aeras.org
Kim, Yoo-Ah, Ph.D., University of Maryland-College Park; Research
Fellow, National Center for Biotechnology Information, National Library of
Medicine, National Institutes of Health. 301-496-3176.
email:yooah.kim@gmail.com
King, Donna, M.S., Florida International University; French, Spanish
and English as a Second Language Teacher, Montgomery County Public
Schools. 252-202-7275.email:dlking009@yahoo.com
Kristensen, David M., Ph.D., Baylor College of Medicine; Postdoctoral

IRTA Fellow, Computational Biology Branch, National Center for
Biotechnology Information, National Library of Medicine, National
Institutes of Health. 301-496-5599. email:dk131363@gmail.com
Kwon, Harry T., Ph.D., University of Maryland at College Park; Health
Scientist Administrator, Office of Communications and Education,
National Cancer Institute, National Institutes of Health. 301-594-8989.
email:harry.kwon@nih.gov
Leppert, Gregory S., Ph.D., Catholic University of America; Staff
Scientist, R/M Nardone Associates, Inc. 301-435-5258.
email: leppertg@mail.nih.gov
Lertora, Juan J.L., M.D., National University of the Northeast, Faculty
of Medicine, Corrientes, Argentina, Ph.D., Tulane University Graduate
School; Director, Clinical Pharmacology Program, Office of Clinical
Research Training and Medical Education, Clinical Center, National
Institutes of Health. 301-496-9425. e-mail: lertoraj@mail.cc.nih.gov
Levin, Henry, Ph.D., University of California, Berkeley; Senior
Investigator, Program in Cellular regulation and Development, Eunice
Kennedy Shriver National Institute of Child Health and Human
Development, National Institutes of Health. 301-402-4281.
email: henrylevin@nih.gov
Lombardo, Fredric, Pharm.D., Duquesne University; M.S., Florida
Institute of Technology; Professor, Clinical and Administrative Pharmacy
Science, College of Pharmacy and Pharmaceutical Sciences, Assistant
Director, Howard University Cancer Center. 202-807-4205 or
202-806-5539. email: flombardo@howard.edu
Lum, Clark K. L., Ph.D., Kansas State University. 301-670-5588.
email: clark.lum@verizon.net
Mackem, Susan, M.D., Johns Hopkins University School of Medicine,
Ph.D., University of Chicago; Senior Investigator, Cancer and
Developmental Biology Laboratory, National Cancer Institute Frederick,
email:mackems@mail.nih.gov
Kirby, Tara, Ph.D., University of Minnesota; Office of Technology Transfer,

National Institutes of Health. 301-435-4426.email: kirbyt@mail.nih.gov
55

Madeo, Anne C., M.S., University of Michigan; Genetic Counselor
and Associated Director, Genetic Counseling Training Program, Social
and Behavioral Branch, National Human Genome Research Institute,
National Institutes of Health. 301-443-2635.email:anne.madeo@nih.gov
Muroff, Julie A., J.D., Georgetown University Law Center; Senior

Attorney, Department of Health and Human Services, Office of the
General Counsel, Public Health Division, Office of the Director, National
Institutes of Health.
Marcus, Stephen E., Ph.D., University of North Carolina, Chapel Hill;

Center for Bioinformatics and Computational Biology, National Institute of
General Medical Sciences, National Institutes of Health. 301-594-2987
e-mail: marcusst@mail.nih.gov
Nandedkar, Arvind K.N., Ph.D., Delhi University, Delhi, India; Professor

of Biochemistry and Molecular Biology, Safety Officer, Howard
University College of Medicine. 202-806-9710.
e-mail: anandekar@howard.edu
Major, Jacqueline, Ph.D., University of California-San Diego; Postdoctoral Fellow, Division of Cancer Epidemiology and Genetics, National
Cancer Institute, National Institutes of Health, 301-451-9873.
email:gsph.jm@gmail.com
Nardone, Mark, B.S., University of Maryland; Operations Manager,

Biotrac Program, R/M Nardone Associates, Inc. 301-496-8290.
email: nardonem@mail.nih.gov
Malone, John, Ph.D., University of Texas-Arlington; Postdoctoral Fellow,

Laboratory of Cellular and Developmental Biology, National Institute of
Diabetes, Digestive, and Kidney Diseases, National Institutes of Health,
301-594-1416. email:smilisca@gmail.com
McDowell, Margaret A., Ph.D., University of Maryland, School
of Public Health, College Park; Nutritionist, Division of Nutrition
Research Coordination, National Institutes of Health. 301-594-8824.
email:Margaret.mcdowell@nih.gov
Metaferia, Belhu B., Ph.D., Virginia Tech; Research Fellow, Pediatric
Oncology Branch, Center for Cancer Research, National Cancer
Institute, National Institutes of Health, 301-594-5409.
email: mshb1170@hotmail.com
Noguchi, Constance T., Ph.D., George Washington University; Chief,

Molecular Cell Biology Section, Molecular Medicine Branch, National
Institute of Diabetes and Digestive and Kidney Diseases, National
Institutes of Health. 301-496-1163. email: connien@mail.nih.gov
Notario, Vicente, Ph.D., University of Salamanca, Spain; Professor,
Chief, Experimental Carcinogenesis Laboratory and Director, Division
of Radiation Research, Department of Radiation Medicine, Georgetown
University Medical Center. 202-687-2102.
email: notariov@georgetown.edu
Nyden, Marc R., Ph.D., Wesleyan University; Research Chemist,
Building Fire Research Laboratory, National Institute of Standards and
Technology. 301-975-6692. email: marc.nyden@nist.gov
Miller, Fran, M.Ed., University of Maryland; Director, Bendara

Communications. 301-309-3768. email: bendara3@yahoo.com
Mitkus, Robert, Ph.D., DABT, University of Maryland, Baltimore;
Toxicologist, CBER, Food and Drug Administration. 301-827-6083.
email: Robert.mitkus@fda.hhs.gov
Momenan, Reza, Ph.D., The George Washington University; Staff
Scientist, Section of Brain electrophysiology and Imaging, Laboratory
of Translational and Clinical Studies, National Institute on Alcohol
Abuse and Alcoholism, National Institutes of Health. 301-451-6972.
email:rezam@nih.gov
Moorman, Yukiyo, B.S., Tokyo University, Tokyo, Japan; Japanese
Language Instructor, Walt Whitman High School, Bethesda, Maryland.
301-602-1726. email: ymoorman@aol.com
Muenke, Maximillian, M.D., Free University, Berlin, Germany; Chief,
Medical Genetics Branch, National Human Genome Research Institute,
e-mail: muenke@nghri.nih.gov
Mukoyama, Yosuke, Ph.D., University of Tokyo, Tokyo, Japan; Tenure
Track Investigator, Laboratory of Developmental Biology, National Heart
Lung and Blood Institute, National Institutes of Health. 301-451-1663.
email: mukoyamay@mail.nih.gov
56
Nardone, Roland M., Ph.D., Fordham University; Professor Emeritus,

Catholic University of America, R/M Nardone Associates, Inc.
301-496-8290. email: rlnard@erols.com
ODonnell, Patrick, DMA, University of Michigan; Instructor, Levine

School of Music. 202-246-8010. email:podonnell@levineschool.org.
Ognibene, Frederick P., M.D., Cornell University; Deputy Director,
Educational Affairs and Strategic Partnerships, NIH Clinical Center.
301-402-0563. email: fognibene@cc.nih.gov
Ou, Oliver, Ph.D., University of Buffalo, Buffalo, NY; Post Doctoral Fellow,
Gene Silencing Section, Genetics Branch, Center for Cancer Research,
email:oul@mail.nih.gov
Patcheva, Ralitza, DMA, University of Maryland College Park;
Artist Diploma from Hochschule fur Musik in Munich in Art Song
Accompaniment (Liedgestaltung); Co-Chair of Chamber Music
Department, Levine School of Music, Adjunct Professor, Director of
Ensemble Programs, Georgetown University, Adjunct Faculty, Catholic
University. 202-243-0601.email:rpatcheva@levineschool.org
Patel, Kushang V., Ph.D., University of Texas; Staff Scientist, Laboratory

of Epidemiology, Demography, and Biometry, National Institute on Aging,
email:Kushang.patel@nih.gov
Provorny, Frederick A., J.D., Columbia University; President, Center for

New Technology Enterprise, Bethesda, Maryland
301-793-1618. email fprovorny@gmail.com
Shebl, Fatma, M.D., University of Alexandria, Egypt; Ph.D., University

of Maryland, Baltimore; Research Fellow, National Cancer Institute,
National Institutes of Health. 301-435-4727.email:sheblf@mail.nih.gov
Pucino, Frank, Pharm D., Massachusetts College of Pharmacy; M.P.H.,

George Washington University; Guest Scientist/Clinical Investigator,
National Institute of Arthritis and Musculoskeletal and Skin Disease,
and National Institute of Diabetes and Digestive and Kidney Diseases,
National Institutes of Health. 301-541-5185. e-mail:fpucino@nih.gov
Shuman Moss, Laurie, Ph.D., Penn State University; Advanced

Technology Center, Radiology Oncology Branch, National
Cancer Institute, National Institutes of Health. 301-402-0870.
email:shumanmossla@mail.nih.gov
Puigbo, Pere, Ph.D., Rovira I Virgili University, Tarragona, Spain;

Postdoctoral Visiting Fellow, Computational Biology Branch, National
Center for Biotechnology Information, National Library of Medicine,
National Institutes of Health. 301-496-9196.email:ppuigbo@gmail.com
Read, Erik, Ph.D., University of Illinois; Research Associate, FDA-CDER.
email:Erik.Read@fda.hhs.gov
Silverman, Marni N., Ph.D., Emory University; Postdoctoral Fellow,

Section on Neuroendocrine Immunology and Behavior, National
Institute of Mental Health, National Institutes of Health. 301-496-4562.
email:mnsilverman.medi522@gmail.com
Sinnarajah, Srikumar, Ph.D., College of Veterinary Medicine, Auburn
University; Senior Research Associate, Laboratory of Immunoregulation,
National Institute of Allergy and Infectious Diseases, National Institutes
of Health. 301-402-1445. email:sinnaras@niaid.nih.gov
Reichman, Uri, Ph.D., The Hebrew University in Jerusalem, Israel;

M.B.A., Iona College; Senior Advisor for Licensing, Office of Technology
Transfer, National Institutes of Health. 301-435-4616.
e-mail: reichmanu@mail.nih.gov
Smith, Erika R., Biomedical & Electrical Engineering/M.B.A.,Vanderbilt

University; Angel Investor and Entrepreneur. 571-334-5242.
email:erikaaesmith@gmail.com
Rittler, Matthew, Ph.D., Virginia Tech, Blacksburg, VA; IRTA Postdoctoral

Fellow, Advanced Technology Center, Radiology Oncology Branch,
email:rittlem@mail.nih.gov
Sorlie, Paul D., Ph.D., Johns Hopkins University School of Hygiene and
Public Health; Epidemiologist-Statistician, Epidemiology and Biometry
Program, National Heart, Lung and Blood Institute, National Institutes of
Health. 301-435-0456. email: sorliep@nih.gov
Rodriguez, Angela, B.A., Universidad Central de Mujeres de

Monterrico, Lima, Peru; Executive Secretary, Embassy of Peru Air
Attache, Washington, D.C. 202-333-1528 ext 3001.
Stanton, Brian R., Ph.D., University of Maryland; Director, Consulting

Branch, Senior Analyst Health, IP and Tech Transfer, Senior Consultant
SET, The REDANDA Group, Inc. 301-685-1335.
email:brobstan@yahoo.com; bstanton@redanda.com.
Roman Maqueira, Juana, Doctoral Candidate, Dowling College, New

York; Senior International Education Consultant, Department of Human
Development, Education and Culture, Organization of American States
(OAS), Washington, DC. 202-486-6876. email:juanaroman@msn.com
Rosenberg, Yves, M.D., University of Lyon, France, M.P.H., Johns
Hopkins University; Program Director, Atherothrombosis and Coronary
Artery Disease Branch, Division of Cardiovascular Diseases, National
Heart, Lung and Blood Institute, National Institutes of Health.
301-435-1292. email:rosenbey@nih.gov
Salicrup, Luis A., Ph.D., Rutgers University; Fulbright Outstanding
Scholar in Global Health. 301-594-9944.email:luis.salicrup@nih.gov
Seabold, Gail Kimberly, Ph.D., University of Wisconsin; Postdoctoral
Fellow/IRTA, Laboratory of Neurochemistry, Section on Neurotransmitter
Receptor Biology, National Institute on Deafness and other
Communications Disorders, National Institutes of Health. 301-594-8303.
e-mail: seaboldg@nidcd.nih.gov
Shah, Deven, Ph.D., University of New York at Buffalo; Vice President,
Asclepius Solutions, Inc., Center for Cancer Research, 301-685-3557.
email:deven.shah@asclepius.net
Sternberg, Esther M., M.D., McGill University; Director, Integrative

Neural-Immune Program and Chief, Section on Neuroendocrine
Immunology and Behavior, National Institute of Mental Health, National
Institutes of Health. 301-402-2773. email: emsternbergmedi522@gmail.
com
Streicher, Howard, M.D., New York University School of Medicine;
Senior Investigator, Division of Cancer Treatment and Diagnosis, Cancer
Therapy Evaluation Program, Investigational Drug Branch, Biological
Evaluation, National Cancer Institute, National Institutes of Health.
301-435-9129. email: streicherh@ctep.nci.nih.gov
Suarez Lissi, Maria A., M.D., National University of Buenos Aires,
Argentina; Contractor, Rehabilitation Medicine Department, Clinical
Center, National Institutes of Health. e-mail: alissi@verizon.net
Szarama, Katherine B., B.A., The Johns Hopkins University; Predoctoral IRTA, Section on Auditory Mechanics and Section on
Developmental Neuroscience, National Institute on Deafness and Other
Communication Disorders, National Institutes of Health. 301-496-7954.
email:szaramak@nidcd.nih.gov
57

Tang, Jane, Ph.D., University of California, Davis: Principal
Microbiologist, Noblis. 703-610-2030 e-mail: Jane.Tang@Noblis.org
Tecuta, Ilie, B.A., University of Bucharest, Romania; Language
and Culture Instructor, Foreign Service Institute, Department of
State.347-306-6759. Email:tecuta@aol.com
White,
Gladys B., Ph.D., Georgetown University; Adjunct Professor,
W
Georgetown
University and Montgomery College.
G
Email:gladys.white@comcast.net
E
Wu,
W Kuei-Meng, Ph.D., University of Kentucky; Senior Expert
Pharmacologist,
Department of Health and Human Services. 301-796P
0835.
email: drkmwu@gmail.com
0
Tiong, Jean, Ph.D., Ohio University; Research Biologist, Cellular and

Developmental Neurobiology, National Institute of Neurological Disorders
and Stroke, National Institutes of Health. 301-496-8131. e-mail: tiongj@
ninds.nih.gov
Vepa, Suryanarayana (Sury), Ph.D., IISC, India, J.D., University of
Maryland; Licensing and Patenting Manager, Office of Technology
Transfer, National Institutes of Health. 301-435-5020. email:vepas@mail.
nih.gov.
Walenta, Jeffrey E., M.B.A., Washington University, St. Louis; Monitoring
Enforcement Specialist, Office of Technology Transfer, National Institutes
of Health. 301-435-5378. e-mail: walentaj@mail.nih.gov
Wang, Philip, Ph.D., University of Maryland; Training Specialist/Graduate
Director of Student Services, Office of Intramural Training and Education,
Graduate Partnership Program, National Institutes of Health.
301-451-8268. Email:wangph@mail.nih.gov
Wang, Sue-Jane, Ph.D., University of California at Los Angeles;
Mathematical Statistician, Office of Biostatistics, Center for Drug
Evaluation and Research, Food and Drug Administration. 301-796-0831.
email:suejane.wang@fda.hhs.gov
Xu,
X Xuehua, Ph.D., Tsukuba University, Japan; Staff Scientist, NIAID,
National
Institutes of Health. 301-594-0692. email:xxu@niaid.nih.gov
N
Yang,
Wei, Ph.D., Columbia University; Section Chief, Laboratory of
Y
Molecular
Biology, National Institute of Diabetes and Digestive and
M
Kidney
Diseases, National Institutes of Health. 301-402-4645. e-mail:
K
wei.yang@nih.gov
w
Young,
Robert S. K., M.D., Ph.D., Yale University; J.D., LL. M.,
Y
Georgetown
University; Center for Drug Evaluation and Research, Food
G
and
a Drug Administration. 301-594-1032. email: bob.young@fda.hhs.gov
Yun,
Y Sijun, Ph.D., Boston University; Postdoctoral Fellow, Laboratory of
Cell
C Biology, National Cancer Institute, National Institutes of Health.
301-496-1397.
email:yuns@mail.nih.gov
3
Zarate,
Jr., Carlos A., M.D., Faculty of Medicine, Catholic University of
Z
Cordoba,
Argentina; Chief, Mood Disorders Research Unit, , Mood and
C
Anxiety
Disorders Program, National Institute of Mental Health, National
A
Institutes
of Health. 301-451-0861. email: zaratec@mail.nih.gov.
In
Weigert, Roberto, Ph.D., Open University, London, UK; Chief,

Intracellular Membrane Trafficking Unit, Oral and Pharyngeal Cancer
Branch, National Institute of Dental and Craniofacial Research, National
Institutes of Health. 301-496-9966. e-mail: weigertr@mail.nih.gov
Weldon, John E, Ph.D., Johns Hopkins University; Research Fellow,
Laboratory of Molecular Biology, National Cancer Institute, National
Institutes of Health. 301-451-8736. e-mail: weldonj@mail.nih.gov.
Wenham, Matt, D.Phil., University of Oxford, UK; Postdoctoral Fellow
(Visiting Fellow), Genetics and Biochemistry Branch, NIDDK, National
Institutes of Health. 301-594-0728.email:matt.wenham@nih.gov
58
NIH Visitors Map
Street Address:
National Institutes of Health
9000 Rockville Pike
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Main Entrance:
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Rockville Pike & NIH Gateway Drive
Pedestrians:
24 hours, 7 days a week
West Gateway Center (Pedestrians Only)
Near Old Georgetown Rd & South Dr
6am - 12pm Monday - Friday
To learn more about visitor and security issues
at the NIH, visit:
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NIH Gateway Center

Vehicle Inspection:
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After 10pm on weekdays, all day weekends and holidays,
all visitor (patients, commercial, non-commercial) vehicles,
motorcycles and bicycles must enter campus at the CVIF
For questions about campus access, please contact

the ORS Information Line at
orsinfo@mail.nih.gov
or
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59
NIH Visitors Map with Perimeter Security

Information for Patients and Visitors to the National Institutes of Health
Street Address:
National Institutes of Health
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Bethesda, MD 20892
Welcome to the NIH. Please take the time to read this bulletin.
It contains important parking and security information you need when visiting the NIH campus.
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parking lot:
Monday Friday, 7am 7pm: $2.00 per hour for the first three hours $12.00 for the entire day
Metered parking lots: Monday Friday, 7am 7pm $2 per hour
The NIH has implemented security measures to help ensure the safety of our patients, employees, guests and
facilities. All visitors must enter through the NIH Gateway Center at Metro or the West Gateway Visitor Center.
You will be asked to submit to a vehicle or personal inspection.
Visitors over 15 years of age must provide a form of government-issued ID such as a drivers license or
passport. Visitors under 16 years of age must be accompanied by an adult.
Vehicle Inspections All vehicles and their contents will be inspected upon entering the campus.
Additionally, all vehicles entering certain parking areas will be inspected, regardless of any prior inspection.
Drivers will be required to present their drivers license and may be asked to open the trunk and hood. If you
are physically unable to perform this function, please inform the inspector and they will assist you.
Vehicle inspection may consist of any combination of the following: Detection Dogs Teams (K-9), Electronic
Detection Devices and Manual Inspection.
After inspection, you will be issued a vehicle inspection pass. It must be displayed on your vehicles
dashboard while you are on campus. The inspection pass is not a parking permit. It only grants your vehicle
access to enter the campus. You can only park in designated parking areas. ( See campus map)
Personal Inspections All visitors should be prepared to submit to a personal inspection prior to entering
the campus. These inspections may be conducted with a handheld monitoring device, a metal detector and
by visible inspection. Additionally, your personal belongings may be inspected and passed through an x-ray
machine.
Firearms, explosives, archery equipment, dangerous weapons, knives with blades over 2 1/2 inches,
alcoholic beverages and open containers of alcohol are examples of prohibited items on the NIH campus.
Visitor passes must be prominently displayed at all times while on the NIH campus.
60
NON PROFIT ORG.

U.S. POSTAGE
PAID
PERMIT 7040
BETHESDA, MD
ONE CLOISTER COURT, SUITE 230

BETHESDA, MD 20814-1460
T: (301)496-7976
F: (301)402-0174
www.faes.org

2011-12 Faes Grad School Catalog

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F A E S

Fifty second year

Calendar for 2011-2012

Last day for mail registration

10 a.m. 4 p.m. August 29, 30, 31, Sept. 1, 2, 6, 7

10 a.m. 4 p.m. Jan. 9, 10, 11, 12, 13, 17, 18

Graduate and Undergraduate

FOUNDATION FOR ADVANCED EDUCATION

FAES Board of Directors

Ann Ashby, M.B.A.

Derek LeRoith, M.D., Ph.D.

Two Hybrid Selection: Identification and Characterization of ProteinProtein Interactions

Chemistry, Physics and Imaging ................................................................................................................................................................................ 24

Pharmacology and Toxicology .................................................................................................................................................................................... 39

Fall 2011 Semester Schedule

Biochemistry and Metabolism of Lipids

Genetic Counseling: Professional Topics Seminar

Regulations and Procedures

Certificate in Technology Transfer Program

a final independent project, totaling 15 credit units. This program is open

Transferring Certificate in Technology Transfer

Public Health Certificate Program

Regulations and Procedures continued

Withdrawals and Refunds

Please note: Late fees are NOT refundable.

These are current fees and are subject to change.

Credit and Grades

Refunds will be computed as of the date the application for withdrawal

4. Visiting Scientist AssistanceThere are at the NIH a large number

The Foundation Bookstore is open to everyone, in or out of Government.

Building 10, Room B1-L-101

Courses numbered 600 and above are continuing medical education

The Foundation Bookstore is regularly open from 8:30 a.m. to 4:00

Foundation Bookstore hours

***First half given in the Fall semester.

First week of classes

3. Awards, Memorial Funds, and Lecture SeriesThe FAES administers

Biochemistry and Biophysics

Martin Gellert, Chairperson,

BIOC 302 is a continuation of BIOC 301. It will cover metabolism and

PLEASE NOTE: THE ABOVE NEW COURSE NUMBERS AND

Selected topics chosen from the recent advances in structural biology

Registration limited to 50 students.

Spring, 1 credit (8 weeks)

Current Methodology in Nucleic Acid Structure and

Biochemistry and Metabolism

Spring, 2 credits, Alternate Years 2012

The Molecular and Cellular Basis

The objective of this course is to expose students to current knowledge and

Spring, 2 credits, Alternate Years, 2013

Recent Discoveries in Molecular Biology

The objective of this postgraduate course is to present late breaking discoveries

New BIOF 411

Benjamin Busby, Chairperson

New BIOF 309

Fall, 1 credit (7 weeks)

New BIOF 312

Summer, 2 credits (2012)

Fall, 2 credits (10 weeks)

This course describes practical applications of publicly available bioinformatics

New BIOF 502

Spring, 1 credit, (8 weeks)

Medical Genomics for

Prerequisite: A solid understanding of biology, computer science or