STUDY 93 - KONGOBOLOLO

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4 Activit antibactrienne des extrait Mong Tuyen Huy Vu

5 Activit antimicrobienne de Bitter GG (Morinda morindoides), une substance anti-diarrhique de source natur
6 ACTIVITE ANTIPLASMODIALE DE OLAX SUBSCORPIOID
http://cat.inist.fr/?aModele=afficheN&cpsidt=22390745
7 Activit de Morinda morindoides sur laMong Tuyen Huy Vu
18 Ant malaria activity of Olax subscorpioidea Oliv and Mor http://www.cabdirect.org/abstracts/20103081420.html;jse
22 Antiamoebic activity of iridoids from Morinda morindoides https://www.thieme-connect.de/products/ejournals/abstra
23 Antiamoebic activity of iridoids from Morinda morindoides https://www.thieme-connect.de/products/ejournals/abstra

24 Antiamoebic and phytochemical screeMong Tuyen Huy Vu

1
25 Antibacterial activity of extracts from the leaves of M
http://www.scopus.com/record/display.url?eid=2-s2.0-848

37 Antidiarrheal activity of the ethyl acet Mong Tuyen Huy Vu

1
41 Antifungal activity of a soap made from Morinda morindoides Back. Miln-Redh (Rubiaceae)BGG
47 Anti-inflammatory and anti-nociceptive effects of crude extract and fractions of Morinda morindoides root bark
52 Antimalarial activity in tropical plants: Mong Tuyen Huy Vu
53 Antimalarial activity of 20 crude extr Mong Tuyen Huy Vu

58 Antimalarial activity of some extracts Mong Tuyen Huy Vu

1
62 Antimalarial compounds isolated fromMong
p
Tuyen Huy Vu
1
65 Antimalarial, Antiamoebic and Cytotoxic Activities of So http://www.cabdirect.org/abstracts/20093054988.html?fre
67 [Antimicrobial activity of Morinda morindoides on in vitro ghttp://www.ncbi.nlm.nih.gov/pubmed/20337116
78 Antiplasmodial activities of some Ghana
Mong Tuyen Huy Vu
94 Antispermatogenic Activity Of Morinda Morindoides Root Bark Extract In Male Wistar Rats
99 Antiviral Activity of Morinda Morindoides Against Herpes Simplex Virus Type 2
107 Assessing African medicinal plants forMong Tuyen Huy Vu
1
116 Biochemical Effects of Methanolic Extract of Morinda Morindoides A
0
117 Biodiversity Assessment and ConservMong Tuyen Huy Vu
0
119 Bioguided isolation of pharmacologicalMong Tuyen Huy Vu
1
124 Botanical survey and in vitro exploration of antifungical activity of Morinda morindoides (Baker) Milne-Redh. o
127 Cardiac Tolerance Study of Morinda mMong Tuyen Huy Vu
128 Cardiovascular activity of total prote Mong Tuyen Huy Vu

1
1

138 Chemistry and Biology of Synthetic a Mong Tuyen Huy Vu

1
143 Cholinergic and anticholinesterase actMong Tuyen Huy Vu
1
150 Comparative study of in vitro susceptibility of clinical and environmental strains of vibrio cholerae O1 strains to

153 Comparative study on the phytochemic

Mong Tuyen Huy Vu
1
157 Complement-inhibiting constituents of Morinda morindoid http://agris.fao.org/agris-search/search.do?recordID=DE9
158 Complement-inhibiting iridoids from Mong Tuyen Huy Vu
1
159 Complement-modulating properties of a kaempferol 7-O-rhttp://cat.inist.fr/?aModele=afficheN&cpsidt=2677787
160 Compositions chimique activit antibaMong Tuyen Huy Vu
1
165 Constituents from Morinda morindoides
Mong Tuyen Huy Vu
169 Contributions to the wood anatomy of Mong Tuyen Huy Vu

1
0

175 Cytotoxic effect induced by Morinda mMong Tuyen Huy Vu

1
176 Cytotoxicity and in vitro susceptibilit Mong Tuyen Huy Vu
187 Distribution of naturally occurring ant Mong Tuyen Huy Vu
189 DOCTORAT DE LUNIVERSIT DE Mong Tuyen Huy Vu
192 EFFECT OF DICHLOROMETHANE-ETHA
Mong Tuyen Huy Vu
193 The effect of freeze-drying and its impMong Tuyen Huy Vu
194 Effect of Morinda Morindiodes Extracts on Organs of Mic http://www.ajol.info/index.php/njpar/article/view/110681
204 Effets de BGG, F5 (fraction chromatographique de Morinda morindoides) sur lactivit contractile du c eur iso
205 Effets de BGG, F5 (fraction chromatographique de Morinda morindoides) sur la pression artrielle carotidienn
211 Entamoeba histolytica
Mong Tuyen Huy Vu

218 In vitro anticomplementary activit Mong Tuyen Huy Vu

220 Ethnobotanical survey of antimalarial Mong Tuyen Huy Vu
223 Ethnopharmacological study of plants Mong
us Tuyen Huy Vu
224 Ethnopharmacological survey of plantsMong Tuyen Huy Vu
226 tude botanique et exploration de la Mong Tuyen Huy Vu
228 tude de lactivit antibactrienne de Mong Tuyen Huy Vu
230 tude des effets deMorinda morindoidMong Tuyen Huy Vu
232 ETUDE PHYTOCHMIQUE ET PHARMA
Mong Tuyen Huy Vu
235 Eurycoma longifolia extract-artemisin Mong Tuyen Huy Vu
236 valuation de laction anti diarrhique de
237 valuation de laction anti-diarrhique et de la tolrance cardiovasculaire de Morinda morindoides un extrait v
238 EVALUATION ET AMELIORATION I Mong Tuyen Huy Vu
239 VALUATION ET ESSAIS DOPTIMISMong Tuyen Huy Vu
245 Evaluation of antioxidant potentials of Morinda morindoidehttp://www.tandfonline.com/doi/full/10.1080/02772248.20
246 Evaluation of antiplasmodial and antifungal activity of Morinda morindoides (Baker) Milne-redh (Rubiaceae), a
248 EVALUATION OF ENZYMATIC ANTIOAbdelrahman Tarek http://journal.biochim.ro/archive/n51-2/pdfs_51-2/rjb51-2_
252 Evaluation of in vivo antiplasmodial acAbdelrahman Tarek http://www.biomedcentral.com/content/pdf/1475-2875-9-S
257 Evaluation of the toxic effect of aqueous extract of the bark of morinda morindoides root in male Wistar rats
258 Evolution of growth habit, inflorescence
Abdelrahman Tarek http://www.plosone.org/article/fetchObject.action?uri=info
265 Five prevalent antiprotozoal herbal dr Abdelrahman Tarek

266 Flavonoid O-Glycosides from the Leaves of Morinda Morindoides

269 The flora of Bossou: its utilization
Abdelrahman Tarek http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433
275 Gastrointestinal activity of the aqueous extract of a Nigerian polyherbal preparation
277 Gene expression profile of tumor cell-fu
Abdelrahman Tarek http://tigerprints.clemson.edu/cgi/viewcontent.cgi?article=
287 Herbal antidiarrhoeals: a review
Abdelrahman Tarek http://www.ijrpbsonline.com/files/30-3235.pdf
291 Hypoglycaemic and hypolipidaemic effe
Abdelrahman Tarek http://actavet.vfu.cz/media/pdf/avb_2012081030269.pdf
295 Hypoglycmie svre induite par la p Abdelrahman Tarek http://moscow.sci-hub.bz/8a832eb0873500bdcc533e900
300 Immunomodulatory Properties of NoniAbdelrahman
(
Tarek http://tigerprints.clemson.edu/cgi/viewcontent.cgi?article=
310 In vitro anticomplementary activity of Abdelrahman Tarek http://ocean.sci-hub.bz/629951c9d21dd8104cc586bbbfed
312 In vitro Antifungal Activity of the Hexanic Extract of Morinda morindoides Leaves Formulated as soap
313 In vitro antifungal activity of the soap formulation of the hexane leaf extract of Morinda morindoides (Morinda;
317 In vitro antiplasmodial activity and cy Abdelrahman Tarek http://ocean.sci-hub.bz/8f5f4e2e42685b09370613933ef7

318 In vitro antiplasmodial activity of 18 plants used in Congo Brazzaville

1
321 In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Re

332 In vivo antitrypanosomal evaluation o Abdelrahman Tarek

1
346 Investigating on related diabetes theraAbdelrahman Tarek http://www.academicjournals.org/article/article138071211
1
353 In-Vitro Anticomplementary Activity of Constituents from Morinda Mo

354 In-vivo antimalarial activity of Cassia occidentalis, Morinda morindoi

365 Isolation of active compounds from the leaves of Morinda morindoides

374 Larvicidal activity of crude extract

Abdelrahman Tarek
1
375 Le kiosque
0
403 Molecular phylogenetics and generic Abdelrahman Tarek http://cyber.sci-hub.bz/MTAuMTAxNi9qLnltcGV2LjIwMDk
0

413 Naturally occurring iridoids and secoir Abdelrahman Tarek https://www.jstage.jst.go.jp/article/cpb/59/7/59_7_803/_pd

1

414 Naturally occurring secoiridoids and bio

Abdelrahman Tarek https://www.jstage.jst.go.jp/article/cpb/55/5/55_5_689/_pd
1
416 Nephrolepis biserrata, une PtridophyAbdelrahman Tarek
0
417 Nphrotoxicit induite par les plantes mdicinales utilises en Rpublique dmocratique du Congo

422 New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides

439 PHCOG MAG.: Review Article Search for medicinal plants as a source
1
450 Phytochemical composition and evaluat
Abdelrahman Tarek http://www.vidyabhartitrust.org/pharmacy/material_docs/1
451 Phytochemical Screening and In vitro Antiamoebic Activity of Extracts from Some Antidiarrhoeal Medicinal Pla

452 Phytochemical screening and in vitro antifungal activities of extrac

1
453 Phytochemical studies of four plants from the Ivory Coast used in traditional medicine
457 Phytopharmacological evaluation of Morinda morindoides for anti-hyperglycemic activity in normal rabbits
459 Plant extracts with antiamoebic properAbdelrahman Tarek http://www.researchgate.net/profile/Nguessan_Jean_Dav
460 Plant-derived antimalarial agents: newAbdelrahman Tarek
463 Plants with Hypolipidaemic Effects fro Abdelrahman Tarek http://cdn.intechopen.com/pdfs-wm/45882.pdf
466 PNK l$\backslash$/lukenyi, OK. Kambu, S. Apers and GL. Tona elf all, 2010. The spasmolytic activity of extra
469 The potential of Nigerian Medicinal Pl Abdelrahman Tarek http://ejournalofsciences.org/archive/vol2no8/vol2no8_17
473 PRELIMINARY TEST FOR THE DETEAbdelrahman Tarek http://www.ijabpt.com/pdf/42035-Adrien.pdf
484 Recherche de nouveaux composs Abdelrahman
acti
Tarek http://thesesups.ups-tlse.fr/349/1/Njomnang_Soh_Patrice
487 Regeneration ecology of the useful floAbdelrahman Tarek http://moscow.sci-hub.bz/0ac6b1fbdb509a6994c61f3d73
490 Renal tolerance study of the ethyl acetate fraction of Morinda morindoides (Baker) Milne-Redhead (Rubiaceae
494 Research Article Study Ethnopharmaco
Abdelrahman Tarek http://saspublisher.com/wp-content/uploads/2013/04/SJA
498 Rsistance bactrienne et phytomolcAbdelrahman Tarek https://tel.archives-ouvertes.fr/tel-00935393/document
507 Ritual uses of palms in traditional me Abdelrahman Tarek http://www.biomedcentral.com/content/pdf/1746-4269-10
518 Simplice D. Karou, Tchadjobo Tchaco Abdelrahman Tarek http://scialert.net/fulltext/?doi=pjbs.2011.149.169
522 The spasmolytic activity of extracts Abdelrahman Tarek http://scialert.net/fulltext/?doi=pjbs.2011.149.169
531 Study of the antibacterial activity of Morinda morindoides (Baker) milne-redheat (rubiaceae) acetatique extrac
532 Study of the effects of Morinda morindodes (Back) on the immune system
533 A Study of the Hepatic Tolerance of the Ethyl Acetate Fraction of Morinda morindoides (Baker) Milne-Redhead
539 A survey of herbs used in traditional obstetrics in South Western Nigeria
541 Therapeutic evaluation and certain effects of drug plant Morinda morindoides in malaria
552 The use of herbal medicine in the treatment and prevention of malaria: a review
559 Vlietinck. 2006. Cytotoxicity and in vi Ali Mahmoud Ahmed
561 Volatiles constituents from leaves of Ali Mahmoud Ahmed
567 [J]
569
Ali Mahmoud Ahmed
571 [J]
Ali Mahmoud Ahmed
(+1)

Kambu, K.( 1990): lments de phytothrapie compare. Plantes mdicinales africaines, CRP, Kinshasa, pp. 1-6,22-23, 86-87

(+2)
(+3)

Cimanga, K., 1997. The biologically active constituents of two African medicinal plants: Cryptolepis sanguinolenta (Lindl.
Cimanga, K., De Bruyne, T., Hu, J.P., Cos, P., Apers, S., Kambu, K., Tona, L., Pieters, L., Vanden Berhge, D., Vlietinck, A
METHODS AND APPLICATIONS OF ANTIMALARIAL ASSAYS
20.1 Plasmodium falciparum AND MURINE P388 LEUKEMIA CELL ASSA
1

Reason if necessName of reviewe 0: Excluded, 1: InReason if necessName of reviewe Checked by

eviewer decision

2nd reviewer decision

3rd member

nce anti-diarrhique de source naturelle sur le vibrion du cholera (Extrait totaux, alcoolique, rsiduel et la fraction FS)

aModele=afficheN&cpsidt=22390745

ect.org/abstracts/20103081420.html;jsessionid=631F916A386C0C02180CF991CA0EF2AB?freeview=true

e-connect.de/products/ejournals/abstract/10.1055/s-2006-931581

e-connect.de/products/ejournals/abstract/10.1055/s-2007-986866

s.com/record/display.url?eid=2-s2.0-84880078402&origin=inward&txGid=4845421D7E1E7D4067CF400B7D4BBAB3.53bsOu7mi7A1NSY7f
1

Redh (Rubiaceae)BGG
ns of Morinda morindoides root bark

ect.org/abstracts/20093054988.html?freeview=true

m.nih.gov/pubmed/20337116

Male Wistar Rats

morindoides (Baker) Milne-Redh. on the growth of Cryptococcus neoformans

1
1

1
1

1
1

1
1

rains of vibrio cholerae O1 strains to ethanol extracts of Morinda morindodes

g/agris-search/search.do?recordID=DE94B0242

aModele=afficheN&cpsidt=2677787

o/index.php/njpar/article/view/110681

sur lactivit contractile du c eur isol de rat

sur la pression artrielle carotidienne de lapin

de Morinda morindoides un extrait vgtal

nline.com/doi/full/10.1080/02772248.2015.1031667

s (Baker) Milne-redh (Rubiaceae), an ivoirian traditional medicinal plant

him.ro/archive/n51-2/pdfs_51-2/rjb51-2_05.pdf
dcentral.com/content/pdf/1475-2875-9-S2-P51.pdf

orindoides root in male Wistar rats

e.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0040851&representation=PDF

ulib.kyoto-u.ac.jp/dspace/bitstream/2433/68093/1/ASM_13_127.pdf

emson.edu/cgi/viewcontent.cgi?article=1473&context=all_dissertations
nline.com/files/30-3235.pdf
cz/media/pdf/avb_2012081030269.pdf
-hub.bz/8a832eb0873500bdcc533e900f84fe8f/zinga2014.pdf
emson.edu/cgi/viewcontent.cgi?article=1806&context=all_theses
ub.bz/629951c9d21dd8104cc586bbbfed8c4c/cimanga1995.pdf

Leaves Formulated as soap

t of Morinda morindoides (Morinda; Rubiaceae)

ub.bz/8f5f4e2e42685b09370613933ef75718/zirihi2005.pdf
1

1
1

1
1

nal plants used in the Democratic Republic of Congo

dmocratique du Congo

1
1
hartitrust.org/pharmacy/material_docs/17/Search%20for%20medicinal%20plants%20as%20a%20source%20of%20anti-inflammatory.pdf

m Some Antidiarrhoeal Medicinal Plants Used in Kinshasa, Democratic Republic of Congo

al medicine
ycemic activity in normal rabbits

chgate.net/profile/Nguessan_Jean_David/publication/256295952_Phytopharmacological_evaluation_of_Morinda_morindoides_for_anti-hyp

pen.com/pdfs-wm/45882.pdf

10. The spasmolytic activity of extracts and some isolated compounds from the leaves of Morinda morindoides (Baker) Mlne-Re

iences.org/archive/vol2no8/vol2no8_17.pdf
com/pdf/42035-Adrien.pdf
ps-tlse.fr/349/1/Njomnang_Soh_Patrice.pdf
-hub.bz/0ac6b1fbdb509a6994c61f3d7399a732/marshall2012.pdf

s (Baker) Milne-Redhead (Rubiaceae) extract in rabbit

r.com/wp-content/uploads/2013/04/SJAMS1256-61.pdf
s-ouvertes.fr/tel-00935393/document
dcentral.com/content/pdf/1746-4269-10-60.pdf
ulltext/?doi=pjbs.2011.149.169
ulltext/?doi=pjbs.2011.149.169

dheat (rubiaceae) acetatique extract (ACE) on in-vitro growth of Escherichia coli strains

morindoides (Baker) Milne-Redhead (Rubiaceae) Extract in Rabbit

des in malaria

RP, Kinshasa, pp. 1-6,22-23, 86-87

plants: Cryptolepis sanguinolenta (Lindl.) Schlechter (Periplocaceae) and Morinda morindoides (Baker) Milne-Redhead (Rubiaceae). PhD Th
ters, L., Vanden Berhge, D., Vlietinck, A.J., 1999. Some constituents from Morinda Morindoides leaves as inhibitors of xanthine oxidase and

Reason if necessaName

3rd member

After discussion

Final decision

ND: No data, not

Country of authoCountry of participants/patients

et la fraction FS)

Congo
Belgium

Nigeria

Congo
Belgium

Congo
Beligium

Belgium

South Africa

Belgium

1
1

Ivory Coast
Ivory Coast

1
1

USA
Ivory Coast

4BBAB3.53bsOu7mi7A1NSY7fPJf1g%3a1

Nigeria

Belgium

1
1

Belgium
Congo

Congo
France

Democratic
Republic of
Congo
Belgium

Congo
France

1
1

Nigeria
Republic of the Congo

Belgium
Democratic Republic of the Congo

Democratic
Republic of
Congo
Belgium

Liberia.

India
1
1

India
Japan

India

Ivory Coast

0of%20anti-inflammatory.pdf

nda_morindoides_for_anti-hyperglycemic_activity_in_normal_rabbits/links/0c960522331a04b3d1000000.pdf

morindoides (Baker) Mlne-Redh.(Rubiaceae)

Redhead (Rubiaceae). PhD Thesis. University of Antwerp, Belgium. pp. 255370.

hibitors of xanthine oxidase and scavenging activities. Pharmaceutical and Pharmacological Communications 5, 419424.

Pulication Year Journal

Country of the firCountry of the plant source

try of participants/patients

Parts used

1998 Journal of Ethnop Congo

Congo

leaves

2009 Tropical Journal Nigeria

Daloa (central west region of I leaves

1999 Journal of Ethnop Congo

Congo

leaves

2008 JOURNAL OF NACongo

DR Congo

leaves

2009 Journal of Pharm Belgium

2004 Journal of Ethnop South Africa

2005 Journal of Ethnopharmacology

International Journal of Biochemistry Research
2013 & Review
Ivory Coast
Ivory Coast
2012 African Journal o Ivory Coast
Ivory Coast

leaves
leaves

2007 American ChemicaUSA

2012 International For Ivory Coast

leaves
leaves

Ivory Coast

2015 European Journal Nigeria

Nigeria

leaves

2002 American Chemical Society and AmeCongo

leaves

1999 Pharm. PharmacoBegium

Congo

leaves

2010 African Journal of Congo

Congo

leaves

Congo
2005 Journal of Ethnop France

Congo

leaves
root

2010 Science World JouNigeria

Nigeria
2012 Journal of Medici Republic of the C Congo

root-bark
Roots

1995 Journal of NaturalBelgium

Congo

leaves

2000 Annals of TropicalDemocratic Republ

Congo

leaves

2014 International Formulae Group

leaves

2011 Pharmaceutical Society of Japan

2007 Pharmaceutical SoIndia

Congo

Leaf

2006 Pharmacognosy MIndia

2011 Journal of Medicinal Plants ResearcIvory Coast

leaves

unications 5, 419424.

Extraction methods

Compound nameCompound structure

a 80% MeOH extract

quercetin 3-0- rhamnoside

ethyl acetate extract

EtOH extract 6%
CH2Cl2 extract 3.2%
Ethanol extract
Dichloromethane extract
Methanol extract

flavonoid
aglycones
Quercetin
Chrysarin
Alizarin

dichloromethane crude extracts

Flavonoids :Antioxidant, anticomplement
Antraquinones: Antiparasitic

EtOH/ethyl acetate/CH2Cl2/ CH3OH

(NH4)2SO4
aqueous decoction
(NH4)2SO4

flavonoids
iridoids

EtOH/CH3OH/C2H6OS

Steroids
Phenolics(+/-)
Saponins
Anthraquinones

CH3OH/EtOAc-/n-BuOH/CH3Cl

iridoids

CH3-COOH

alkaloids and flavonoids

flavonoids

CH3OH/toluene/MtBE/EtOAc/n-BuOH/(CH)SO

EtOH/DCM

H20
X
Soxhlet extraction/n-hexane/MeOH flavonoid
CHCI,, EtOAc, n-BuOH
aglycones

EtOH/CH2Cl2/Lyophilization

petroleum ether

iridoids, secoiridoi6' -O-Acetyl-3'' -methoxygaertneroside

Three iridoids, gaertneroside, gaertneri

MeOH fraction

MeOH

Phenylpropanoid conjugated iridois 1

2
3

Quercetin,
quercetin 30
rhamnoside
(quercitrin)
quercetin 3-0
rutinoside (rutin)

Alkaloids
Polyphenols
Tannins
Flavonoids
Saponins
Quinones
aqueous, ethanol, ethyl acetate and Sterols

Antimalarial
Antimalarial assay
IC50 (need to fill unit)

IC50 of comparedType of assay

400 mg/kg

Quinine dihydrochlin vitro

1/ 94.2 3.4 (g/ml)

1/
> 100
18.2
uM
2/
> 50uM
105.4

Quinine 2 HCl (0.1in vitro

60.4 uM

in vitro

200 mg/kg

in vivo

ticomplement
c

(mg/mL)
-Amylase- -Glucosidase
6.430.01 -2.050.01 (methanol)
5.630.02-2.680.02 (ethanol)
X
EtOAc: 55.79.5 ug/mL
n-BuOH: 89.1 6.1 ug/mL

CONSIDER
P388 /L1210/ K562
Toluene (6.0 1.4/6.5 2.1/12.2 1.7)
MtBE (13.0 2.8/19.5 3.5/17.5 3.5)
EtOAc (37.5 3.5/57.7 3.1/60.0 2.8)
Doxorubicin (0.03 0.01/0.04 0.01/ 0.05 0.03)

>100 ug/ml

in vitro

400Mg/Kg
X

artesunate 100mg/kg start+ 50mg/kg (next 5 days)

diminazene aceturate 3.2mg/kg
Untreated control In vivo
X

ED50< 200 mg/kg.day

Quinine dihydrochin vivo

tyl-3'' -methoxygaertneroside
Gaertneria morindoides: 58, 71 and 69uM (anti-complementary activity)

0.1 uM
4.1 uM
21.9

Quinine 40 ng/mL in vitro

0.8
0.04

NOTE (DISCUSSION)
Cytotoxicity assay
Plasmodium strain

Description of CyCytotoxicity (%)

Plasmodium falciparum
1.Congolese strain of P. falciparum
berghei berghei
2.NF 54/64 strain of P. falciparum
berghei berghei

inhibition <50%
1. (21.3-20.73-19.8)
2. (9.6-7.5-5.7)
3. (15.3-12.4-10.9)

P. falciparum

Plasmodium.berghei

74%

IC50 (1.80.2 ug/ml)- ether extract

IC50 (94.2 ug/ml) - ethanolic extract
Plasmodium falciparum FcM29, a chloroquine-resistant strain

T. b. brucei

Mean survival Time (Days)

12.600.7
Parasitaemia level 6.000.0/
3.800.7/ 6.000.0/ 7.800.7/
7.800.7

Plasmodium berghei

Ethanol (200mg/kg.day) 31.3(2.8) -(800mg/kg.day) 37.1 (5.2)

Dichloromethane (200mg/kg.day) 74.0 (3.3)- (800mg/kg.day) 84.0 (4.5)
Lyophilized aqueous (200mg/kg.day) 22.6 (3.9)

Anopheles larvae

P. falciparum CDC1, cycloguanil resMTT assay of 150

9.3
4.3

(DISCUSSION)

LDH activity, Mg2+, Cl-: unchanged

AST, ALT, CPK, Na+,
CONSIDER
K+,
Ca2+: slightly
increase
heart
mechanical
activity:
36 beats/min to 24 beats/min
Cardiovascular actCONSIDER
antiamoebic:
E. histolytica,
duodenal contractility:
100% inhibited by nifedipine at 1 g/mL
hydrolytic action of AChE: KM = 578 M and Vmax = 5687 mM/min

CONSIDER :
Inhibitory
potency, Effect of
administration of
ethanol extract

in vitro

human chronic myeloid leukemia K562 cell line

the murine leukaemia
CONSIDER:
P388 andApoptotic
L1210 cell
and
lines
necrotic evaluation

1.80.2 ug/ml)- ether extract

94.2 ug/ml) - ethanolic extract

anticomplementa
ry activity
in vitro

g/kg.day) 37.1 (5.2)

3)- (800mg/kg.day) 84.0 (4.5)
(3.9)

Larvicidal
activity(1 g of
crude extract in
10 ml
petroleum ether)
Concentration :
50-100-150-200250
% Mortality: 5256-88-96-100

antimalarial
in vitro, P.
falciparum
in vivo mice
P.berghei

Control:
0.1ml of
petroleum ether
in a 250 ml
beaker

inhibition of
classical pathway
of
complement
system

antifungal activitieIn vitro

Candida albicans
(yeast) and
CONSIDER
Trichophyton
Survival
rubrum (mould) hexane extract: C.percentage