Beruflich Dokumente
Kultur Dokumente
Antidepressant Treatment
for Bipolar Depression
n engl j med 3 5 6 ; 1 7
www.nejm.org april 2 6, 2 0 0 7
Introduction
1st the data providing sup -port for their use in treating
bipolar depression are minimal and are not considered to be
suffi -cient to guide clinical practice.
2nd the widely held belief that antidepressants can
induce new episodes of abnormal mood elevation or
acceler -ate the rate of cycling has been neither
confirmed nor refuted by placebo-controlled studies
Methods
multi-center,
double-blind,
randomized,
placebo-controlled,
parallel-group study of standard antidepressants (either
bupropion or paroxetine) as adjuncts to treatment with
mood stabilizers (lithium, valproate, carbamazepine, or
other FDA-approved antimanic agents)
at 22 centers in the United States between November
1999 and July 2005.
Methods
Subject
Intervention
Outcomes
Result
Discussion
Limitations
Summary
CRITICAL APPRAISAL
1
NOT YET