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DS5565 Industry 2015,Share and Size,Trends and

Price,Forecast and Market Analysis to 2022

Summary
Neuropathic pain (NP) is defined as a disorder of the sensorimotor system and is distinctly different
from nociceptive pain, which is a consequence of trauma, injury, or inflammation. The main difference
between neuropathic and nociceptive pain is the absence of a continuous nociceptive input in
neuropathic pain. Although the term neuropathic pain is used to describe a wide range of pain
syndromes with varying etiologies, this report focuses on 3 distinct forms of NP: Painful diabetic
neuropathy, Postherpetic neuralgia and trigeminal neuralgia. The main classes of drugs used to treat
these three neuropathic pain indications include anticonvulsants, antidepressants, opioids and topical
treatments. However, despite the availability of multiple pain medications only 50% of patients respond
to any given drug and there are numerous the side effects associated particularly with systemically
administered drugs, that reduce their tolerability. New treatments will target some key unmet needs in
terms of efficacy and tolerability, but opportunities will remain for drugs that can more reliably
eradicated NP in targeted patient populations, as well as offering an improved safety profile.
DS-5565 is an oral, small-molecule analgesic being developed by Daiichi Sankyo for the treatment of
PDN. It is a voltage-dependent calcium channel alpha-2-delta ligand, meaning that it has a mechanism of
action similar to Lyrica and gabapentin, and reduces pain through the inhibition of calcium channelassociated currents. These compounds bind to the a-2-d subunits (a-2-d-1 and a-2-d-2) of voltagedependent calcium channels, where the a-2-d-1 subunit is the main target for the analgesic effect of a-2-

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d ligands, while the a-2-d-2 subunit is thought to contribute to the CNS side effects of a-2-d ligands,
although this has not been fully demonstrated (Yokoyama et al., 2013).
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Scope

Overview of Neuropathic pain, including epidemiology, etiology, symptoms, diagnosis, pathology

and treatment guidelines as well as an overview on the competitive landscape.
Detailed information on DS-5565 including product description, safety and efficacy profiles as well
as a SWOT analysis.
Sales forecast for DS-5565 for the top seven countries from 2012 to 2022.
Sales information covered for the US, France, Germany, Italy, Spain, the UK and Japan.

Reasons to buy
Understand and capitalize by identifying products that are most likely to ensure a robust return
Stay ahead of the competition by understanding the changing competitive landscape for
Neuropathic pain
Effectively plan your M&A and partnership strategies by identifying drugs with the most promising
sales potential
Make more informed business decisions from insightful and in-depth analysis of DS-5565
performance
Obtain sales forecast for DS-5565 from 2012-2022 in the top seven countries (the US, France,
Germany, Italy, Spain, the UK and Japan).
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Table of Contents
1 Table of Contents 5
1.1 List of Tables 8
1.2 List of Figures 9
2 Introduction 10
2.1 Catalyst 10
2.2 Related Reports 10
3 Disease Overview 12
3.1 Clinical Manifestations of Neuropathic Pain - Signs and Symptoms 14
3.1.1 Painful Diabetic Neuropathy 16
3.1.2 Postherpetic Neuralgia 17
3.1.3 Trigeminal Neuralgia 17

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3.2 Etiology and Pathophysiology 18
3.2.1 Etiology 19
3.2.2 Pathophysiology 20
4 Disease Management 28
4.1 Diagnosis and Treatment Overview 28
4.1.1 Diagnosis 28
4.1.2 Treatment Overview and Guidelines 35
5 Competitive Assessment 45
5.1 Overview 45
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