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MYELOID LEUKEMIA

FAB
FAB Mo

WHO
Acute
Myeloblastic
Leukemia not
categorized
Acute
Myeloblastic
Leukemia
without
maturation

FAB M1

CHARACTERISTICS

Undifferentiated
blasts

Most common
leukemia in <18
mos old
Typical : adults
median age of
46 y.o
Bone
tenderness,
ulcerated
mucous
membranes,
petechiae and
purpura
Hemorrhagic

manifestations

FAB M2

FAB M3

Acute
Myeloblastic
Leukemia with
maturation

Acute
promyelocytic
leukemia

M3
Hypergranular

Most aggressive
type of acute
leukemia with
severe bleeding
tendency and

LABORATORY
FINDINGS
Immunological
markers
immunophenotypi
ng
Predominance of
blasts in PB & BM
without further
maturation of
myeloid cells.

Myeloblasts
predominate
Auer rods
(commonly
seen)
faggots
Anemia
Thrombocytope
nia
Leukopenia
Promyelocytes

STAINING
REACTION

POSITIVE TO :
SUDAN
BLACK B
PEROXIDASE
NAPHTHOL
AS-D
CHLOROACET
ATE
ESTERASE

NEGATIVE TO:
NONSPECIFI
C
ESTERASES

M3m

promyelocytic
leukemia

fatal

Microgranular
Promyelocytic
leukemia

FAB M4

Acute
myelomonocytic
leukemia

Naegeli-type
monocytic
leukemia
Age: adults >50
y.o
Pharyngitis
gingival
hyperplasia
leukostasis

FAB M5

Schilling
leukemia

M5a
Acute
monoblastic

Young adults
(large blasts in BM &
PB)

(predominate
in BM)
Myeloblasts
and myelocytes
with many
small auer rods
Reciprocal
translocation
(15&17)
Anemia
Thrombocytop
enia
Proliferation of
granulocytes
and monocytes
Acquired
pseudo-pelgerhuet anomaly
may be seen
Both myeloid
and monocytic
cells are
present to the
extent of at
least 20% of
the total
leukocytes.
Anemia
Thrombocytop
enia
Monocyte and
promonocyte

POSITIVE TO :
SUDAN
BLACK B
PEROXIDASE
NAPHTHOL
AS-D
CHLOROACET
ATE
ESTERASE
A-NAPHTHYL
BUTYRATE
AND ACETATE
ESTERASE
(NONSPECIFI
C
ESTERASES)
POSITIVE TO :
PAS
NONSPECIFIC
ESTERASES

M5b

leukemia
Acute monocytic
leukemia

FAB M6

Acute
erythroleukemi
a

FAB M7

Acute
megakaryoblas
tic leukemia

Peak: middle age


(differentiated type)
Monoblasts
Promonocytes
Monocytes

Vewry resistant to
treatment
(short life expectancy)
Di Guglielmo
syndrome
Or erythemic
myelosis

Radiographic
evidence of lytic
bone lesions in

(25-75% of
nucleated
cells)
Most cells are
monocytic

BM & PB :
blast cells of
erythroid and
myeloid origin
Abnormal
proliferation
of both
erythroid and
granulocytic
precursors
May include
abnormal
megakaryocyti
c and
monocytic
proliferations
Cytopenia
(thrombocytop
enia)

POSITIVE TO :
PAS
A-NAPHTHYL
ACETATE
ESTERASE

POSITIVE TO :
PAS
ACID

children

L1
Homogenous
L2
Heterogenous
L3
Burkitt lymphoma type

Children
Older children and
adults
Patients with
leukemia secondary
to Burkitt lymphoma

Poor prognosis
especially on
infants
Large and
small
megakaryocyte
s with a high
nuclearcytoplasmic
ratio; pale,
agranular
cytoplasm

PHOSPHATAS
E (UNIQUE IN
FAB M7)