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FAB
FAB Mo
WHO
Acute
Myeloblastic
Leukemia not
categorized
Acute
Myeloblastic
Leukemia
without
maturation
FAB M1
CHARACTERISTICS
Undifferentiated
blasts
Most common
leukemia in <18
mos old
Typical : adults
median age of
46 y.o
Bone
tenderness,
ulcerated
mucous
membranes,
petechiae and
purpura
Hemorrhagic
manifestations
FAB M2
FAB M3
Acute
Myeloblastic
Leukemia with
maturation
Acute
promyelocytic
leukemia
M3
Hypergranular
Most aggressive
type of acute
leukemia with
severe bleeding
tendency and
LABORATORY
FINDINGS
Immunological
markers
immunophenotypi
ng
Predominance of
blasts in PB & BM
without further
maturation of
myeloid cells.
Myeloblasts
predominate
Auer rods
(commonly
seen)
faggots
Anemia
Thrombocytope
nia
Leukopenia
Promyelocytes
STAINING
REACTION
POSITIVE TO :
SUDAN
BLACK B
PEROXIDASE
NAPHTHOL
AS-D
CHLOROACET
ATE
ESTERASE
NEGATIVE TO:
NONSPECIFI
C
ESTERASES
M3m
promyelocytic
leukemia
fatal
Microgranular
Promyelocytic
leukemia
FAB M4
Acute
myelomonocytic
leukemia
Naegeli-type
monocytic
leukemia
Age: adults >50
y.o
Pharyngitis
gingival
hyperplasia
leukostasis
FAB M5
Schilling
leukemia
M5a
Acute
monoblastic
Young adults
(large blasts in BM &
PB)
(predominate
in BM)
Myeloblasts
and myelocytes
with many
small auer rods
Reciprocal
translocation
(15&17)
Anemia
Thrombocytop
enia
Proliferation of
granulocytes
and monocytes
Acquired
pseudo-pelgerhuet anomaly
may be seen
Both myeloid
and monocytic
cells are
present to the
extent of at
least 20% of
the total
leukocytes.
Anemia
Thrombocytop
enia
Monocyte and
promonocyte
POSITIVE TO :
SUDAN
BLACK B
PEROXIDASE
NAPHTHOL
AS-D
CHLOROACET
ATE
ESTERASE
A-NAPHTHYL
BUTYRATE
AND ACETATE
ESTERASE
(NONSPECIFI
C
ESTERASES)
POSITIVE TO :
PAS
NONSPECIFIC
ESTERASES
M5b
leukemia
Acute monocytic
leukemia
FAB M6
Acute
erythroleukemi
a
FAB M7
Acute
megakaryoblas
tic leukemia
Vewry resistant to
treatment
(short life expectancy)
Di Guglielmo
syndrome
Or erythemic
myelosis
Radiographic
evidence of lytic
bone lesions in
(25-75% of
nucleated
cells)
Most cells are
monocytic
BM & PB :
blast cells of
erythroid and
myeloid origin
Abnormal
proliferation
of both
erythroid and
granulocytic
precursors
May include
abnormal
megakaryocyti
c and
monocytic
proliferations
Cytopenia
(thrombocytop
enia)
POSITIVE TO :
PAS
A-NAPHTHYL
ACETATE
ESTERASE
POSITIVE TO :
PAS
ACID
children
L1
Homogenous
L2
Heterogenous
L3
Burkitt lymphoma type
Children
Older children and
adults
Patients with
leukemia secondary
to Burkitt lymphoma
Poor prognosis
especially on
infants
Large and
small
megakaryocyte
s with a high
nuclearcytoplasmic
ratio; pale,
agranular
cytoplasm
PHOSPHATAS
E (UNIQUE IN
FAB M7)