RIAPHYLLIN

COMPOSITION:
Syrup: Each5 ml contains 60 mg Theophylline BP.

CUNICALPHARMACOLOGY:
Riaphyllin pharmacologically acts as a bronchodilator, pulmonary
vasodilator and smooth muscle relaxant. Since it directly relaxes
the smooth muscles of bronchial airways and pulmonary blood
vessels, its actions are believed to be mediated through inhibition
of phosphodiesterase and a resultant increase in intracellular cyclic
-AMP.
INDICATIONS:
Riaphyllin is indicated for the treatment of the symptoms and
reversible airflow obstruction associated with chronic asthma and
other chronic lung diseases, e.g., emphysema

PRECAUTIONS:
Theophylline should be used with caution in patients with severe
cardiac disease, hypertension, hyperthyroidism, acute myocardial
injury, congestive heart failure, hepatic impairment and epilepsy.
It should be used with caution in patients with peptic ulcer and in
who are sensitive to Xanthine

derivatives.

theophylline clearance and increased doses of

theophylline might therefore be required.
Smoking may increase

WARNING:
Contains Sulphites: Can cause allergic type reactions including
anaphylactic symptoms, or severe asthmatic episodes in susceptible
persons.
The herbal remedy St. Johns wort (Hypericum perforatum) should
not be taken at the sametime asthis medicine. If you already take St.
Johns wort, consult your doctor before stopping the St. Johns wort
preparations.
Xanthines can potentiate hypokalemia resulting from Beta-2 agonist
therapy, steroids, diuretics, and hypoxia. Particular caution is advised
in severe asthma. It is recommended that serum potassium levels are
monitored in such situations.
ADVERSEREACTIONS:
The most common side effects with Theophylline are nau sea,
vomiting....diardw-ea
headache.Lrestlessness insomnia, mu scle
twitching and reflex hyper-excitability.
Drug interaction:
- Cimetidine, Allopurinol, Corticosteroids or Steroids, Frusem ide,
Isoprenaline, oral Contraceptives, Thiabendazole, Cipnofloxacin,
Erythromydn or other antibiotics and Calcium Channel
Blockers, Diltiazem and Verapamil, Nizatidine, Norfloxacin,
Isoniazid, Fluconazole, Carbimazole, Mexiletine, Propafen one,
Oxpentifylline, Disulfram, Viloxazine, Interferon Alfa and Influe nza
vaccine increase plasma theophylline concentrations, A reducti on
of the theophylline dosage is recommended.
Phenytoin,
Carbamazepine,
Barbiturates,
Rifampicin,
Sulphinpyrazone, Ritonavir, Primidone and Aminoglutethim ide
may reduce.plasma.theoobsume
oncentration.and therefore.th
theophylline dosage may need to be increased.
- Theophylline can increase Uthium excretion.
- The concomitant use of Theophylline and Fluvoxamine should
usually be avoided. Where this is not possible, patients should
have their theophylline dose halved and plasma theophylline
should be monitored closely.

Revised

October.

USEDURINGPREGNANCYAND LACTATION:
Use ofTheophylline in pregnant women should be balanced against
the risk of uncontrolled asthma. Excretion of Theophylline in breast
milk may cause irritability in the infant. For both cases, Theophylline
Should be prescribed only under doctor's supervision.
DOSAGE:
Majntenance

Dose

Population

Acute Symptoms
Oral Theophytline

Group

Premature inhmts newbom

bradycardia)

(MG/KG/DAYI

6 weeks (for apnea/

6 weeks - 6 months

10

Infants 6 months - 1 year

12 18

Children 1-9~ars

20-24

Children 9 - 12 years and a~nt

d~
othHwbe
so years.

daily smokers
adulttYnOlcrr5

2012

I.

16

Adol~scents 12 - 16 years.
Ot~ise
healthy
elderly patients)
cardiac decompensation
dysfunction

13

nonsmoking

adults

(includil'l8

Of Ptllmonary and/Of

nve-

10 (not to elCC~ 900

"'IId..,1
S(notlOexc~400
"'IIday)

OVERDOSAGE:
Overdose is characterised by nausea,vomiting (often
severe), epigastric pain, haematemesis, restlessness, hypertonia,
impaired consciousness, exaggerated limb reflexes and convulsions,
and arrhythmias. In addition, hypokalemia, hyperglycaemia,
hypomagnesaemia and metabolic acidosis may occur.
Activated charcoal or gastr1c lavage should be considered ,f
a significant overdose has been ingested within 1-2 hours.
Management is followed by symptomatic relief.
STORAGE:
Store below 25C, protect from
t,
Do not use the drug after the expiry date printed on the package.
PRESENTAnON:
Syrup: 100 ml bottles.
Do Not Freeze
To Report any side eff&et(s) or Quality Problems:
National Phannacovigilance Center (NPC)o t-ax :+!lt5o-1-<'U!>-f0t5<'
o E-mail: npc.drug@sfda.gov.sa
o websrte: www.sfda.gov_sa/npc

~~-,-

This is a medicament
A medicament js a product. ~
d:ts 'JOAI t.aIlh. and r.s ~
contrary to instructJons is ~
tar)'OO..
Follow strictly the doc:;tgr's pra5Q'lpbDn. the method of use and the Inn'Ucbons
the pharmacist who sold the ~
The doctor and the phamacist en expertS In medcine, ItS beoeftts and nsks.
00 not by yoOOlelf nt8l'TUpt the penod of tncnenl pn!5CI'bed ror you
00 not repeat the same pn!J5CnPbOnwtthout c:::onsUbng you- doctor

K_

of

medicaments

out of the rea<:h of chUdren

CouncH of Arab Health Ministers
Union of Arab Phannacists

'-C.

'=-oi.

pharmacia

Manufactured by Riyadh Pharma

Medical and Cosmetic Products Co. Ltd.
Riyadh, Saudi Arabia.

pharmacia

RIY~

SYRUP

- Theophylline should not be administered concurrently with other

Xanthine medications.
Plasma concentration of theophylline can be reduced by
concomitant use of the herbal remedy StJohn's wort (hypericum
perforatum).

and chronic bronchitis.

CONTRAINDICATIONS:
Riaphyllin is contraindicated in patients with hypersensitivity
(allergic) to theophylline or any of the other ingredients of this
product.
Riaphyllin is contraindicated in children taking ephedrine (found in
some cough medicines and decongestants).

patients

pharmacia

100ML

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".':F.='.e.' '.,__

AIAPHYlLiN is a trademark
ITEM

~!RD~--m,

CODE:

PIL0469

__ _