Beruflich Dokumente
Kultur Dokumente
Author
Charles R Woods, MD, MS
Section
Sheldon
L
Gregory Redding, MD
Deputy
Carrie Armsby, MD, MPH
Editors
MD
Kaplan,
Editor
Disclosures: Charles R Woods, MD, MS Other Financial Interest: Cerexa [Epiglottitis (Data Safety Monitoring Board for pediatric trials of the antibiotic
agent ceftaroline)]. Sheldon L Kaplan, MDGrant/Research/Clinical Trial Support: Pfizer [vaccine (PCV13)]; Forest Lab [antibiotic (Ceftaroline)]; Optimer
[antibiotic (fidaxomicin)]. Consultant/Advisory Boards: Pfizer [vaccine (PCV13)]. Gregory Redding, MD Nothing to disclose. Carrie Armsby, MD,
MPH Nothing to disclose.
Contributor disclosures are reviewed for conflicts of interest by the editorial group. When found, these are addressed by vetting through a multi-level
review process, and through requirements for references to be provided to support the content. Appropriately referenced content is required of all
authors and must conform to UpToDate standards of evidence.
Conflict of interest policy
All topics are updated as new evidence becomes available and our peer review process is complete.
Literature review current through: Jul 2015. | This topic last updated: Feb 18, 2015.
INTRODUCTION Croup is a respiratory illness characterized
(See"Hoarseness
Laryngotracheobronchitis
(See "Croup:
Approach
Pharmacologic
to
and
supportive
in
children:
Etiology
(LTB)
occurs
and
when
interventions".)
inflammation
superinfection
Bacterial
below. In the past, the term croup also has been applied to
is
and
laryngotracheitis.
those
discussed
into
the
lower
airways
laryngotracheobronchopneumonitis,
separately.
(See "Epidemiology
Laryngotracheobronchitis,
can
tracheitis
which
be
manifest
(also
manifest
which
called
themselves
as
results
in
sometimes
pneumonia,
bacterial
as
croup)
LTB
or
laryngotracheobronchopneumonitis) or as a primary
and
are
evaluation
discussed
of
in
other
causes
of
detail
separately.
A9, B4, and B5, and echovirus types 4, 11, and 21), and
Croup
also
may
be
caused
by
bacteria. Mycoplasma
laryngotracheitis,
laryngotracheobronchitis,
laryngotracheobronchopneumonitis.
The
most
or
common
bacterial
pathogens
include Staphylococcus
aureus, Streptococcus pyogenes, and S. pneumoniae [1].
secondary
The
microbiology,
parainfluenza
pathogenesis,
infections
are
and
epidemiology
discussed
of
separately.
varies
geographically.
(See "Coronaviruses",
section on 'Respiratory'.)
Most cases of croup occur in the fall or early winter, with the
major incidence peaks coinciding with parainfluenza type 1
activity (often in October) and minor peaks occurring during
periods of respiratory syncytial virus or influenza virus activity.
(See "Respiratory syncytial virus infection: Clinical features and
diagnosis", section on 'Seasonality' and "Seasonal influenza in
children: Clinical features and diagnosis", section on 'Influenza
activity'.)
supraglottic
tissues
usually
are
normal.
(See "Bacterial
Host
to 1997 were 0.4 to 1.1 per 1000 children for children younger
than one year and 0.24 to 0.61 per 1000 children for children
development
factors Only
of
small
croup
fraction
include
of
children
functional
or
with
anatomic
laryngomalacia,
hemangiomas [3]
trachea.
laryngeal
clefts,
or
subglottic
airway
narrowing
(human
from
respiratory
papillomavirus),
tract
post-intubation
studies
parainfluenza
children.
diminished
Laryngoscopic
evaluation
of
patients
during
acute
that
demonstrated
virus-specific
histamine-induced
increased
IgE
production
and
suppression
of
of
increased
lymphocyte
impaired
[2,18-20].
Autopsy
studies
in
children
with
In
spasmodic
croup,
findings
on
direct
laryngoscopy
air.
Deviations
from
consideration
of
this
expected
diagnoses
course
other
than
should
prompt
laryngotracheitis.
Rarely,
children
may
benefit
from
treatment
with
Other
management".)
upper
obstruction
airway
obstruction.
As
upper
airway
agitation.
or
bronchoscopy.
(See 'Host
factors' above
respiratory
failure.
(See "Croup:
peritonsillar
retropharyngeal
observational
Cyanosis or pallor
or
retropharyngeal
cellulitis,
study,
and
drooling
abscesses,
epiglottitis.
was
In
an
present
in
[1,41]:
muscles)
efforts
deterioration [32,42].
have
been
reported
to
precipitate
abscesses.
suggests
lower
respiratory
tract
involvement
(eg,
laryngotracheobronchitis,
laryngotracheobronchopneumonitis,
or
bacterial
tracheitis).
increased
insensible
losses
from
fever
and
assessment The
severity
of
croup
is
often
salivation,
suggestive
of
acute
abscess
Diphtheritic membrane
stridor at rest. Children with mild croup may have stridor when
abscess
DIAGNOSIS
Imaging
Indications Radiographic
confirmation
of
acute
requiring
hospitalization
or
for
called
the
"thumb
sign"
(image
3).
(See"Epiglottitis
demonstrate
only
nonspecific
edema
or
intraluminal
section on 'Diagnosis')
Blood tests The white blood cell (WBC) count can be low,
normal, or elevated; WBC counts >10,000 cells/microL are
common. Neutrophil or lymphocyte predominance may be
'Laboratory diagnosis')
Microbiology Confirmation of
etiologic
diagnosis
is
not
necessary for most children with croup, since croup is a selflimited illness that usually requires only symptomatic therapy.
When
an
etiologic
diagnosis
is
necessary,
viral
(see "Clinical
manifestations
and
Metapneumovirus
(see "Human
metapneumovirus
(see "Coronaviruses",
section
on
'Diagnosis')
In addition, multiplex tests, which assess the presence of
multiple agents at the same time, and PCR-based tests are
becoming more widely available [48].
trachea,
stridor.
producing
croup
(See "Airway
bodies
of
barking
cough
foreign
bodies
the
esophagus
and
in
and
Acute epiglottitis
Allergic reaction
Acute angioneurotic edema
Laryngeal
diphtheria
(see "Clinical
manifestations,
against Haemophilus
influenzae type
b,
is
etiologic
pathogen.
(See "Epiglottitis
fistula",
section
on
features' and"Hoarseness
and
abscess",
section
infections
'Bronchogenic
in
on
children",
in
children:
Etiology
and
th
appearance,
th
th
and
severe
respiratory
distress.
the 10 to 12 grade reading level and are best for patients who
medical jargon.
Here are the patient education articles that are relevant to this
of
upper
airway
obstruction.
(See 'Overview'above.)
keyword(s) of interest.)
Basics)")
whether there
predispose
are any
to
severe
course.
upper
including
laryngotracheobronchitis,
respiratory
laryngitis,
bacterial
conditions
laryngotracheitis,
tracheitis,
or
in
children,
spasmodic
croup.
respiratory
syncytial
virus
and
influenza
virus.
of
Important
considerations
distress.
include
The
acute
primary
epiglottitis,
REFERENCES
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
Editors
MD
Kaplan,
Editor
Disclosures: Charles R Woods, MD, MS Other Financial Interest: Cerexa [Epiglottitis (Data Safety Monitoring Board for pediatric trials of the
antibiotic agent ceftaroline)]. Sheldon L Kaplan, MDGrant/Research/Clinical Trial Support: Pfizer [vaccine (PCV13)]; Forest Lab [antibiotic
(Ceftaroline)]; Optimer [antibiotic (fidaxomicin)]. Consultant/Advisory Boards: Pfizer [vaccine (PCV13)]. Anna H Messner, MD Nothing to
disclose. Carrie Armsby, MD, MPH Nothing to disclose.
Contributor disclosures are reviewed for conflicts of interest by the editorial group. When found, these are addressed by vetting through a multilevel review process, and through requirements for references to be provided to support the content. Appropriately referenced content is
required of all authors and must conform to UpToDate standards of evidence.
Conflict of interest policy
All topics are updated as new evidence becomes available and our peer review process is complete.
Literature review current through: Jul 2015. | This topic last updated: Apr 17, 2015.
INTRODUCTION Croup (laryngotracheitis) is a
respiratory illness characterized by inspiratory stridor,
barking cough, and hoarseness. It typically occurs in
children six months to three years of age and is chiefly
caused by parainfluenza virus. (See "Croup: Clinical
features, evaluation, and diagnosis".)
Most children with croup who seek medical attention
have a mild, self-limited illness and can be successfully
managed as outpatients. The clinician must be able to
identify children with mild symptoms, who can be safely
managed at home, and those with moderate to severe
croup or rapidly progressing symptoms, who require full
evaluation and possible treatment in the office or
emergency
department
setting.
(See 'Severity
assessment' below and 'Outpatient treatment' below.)
There is no definitive treatment for the viruses that cause
croup. Pharmacologic therapy is directed toward
decreasing airway edema, and supportive care is
directed toward the provision of respiratory support and
the maintenance of hydration. Corticosteroids and
nebulized epinephrine are the cornerstones of therapy;
their use is supported by substantial clinical evidence.
(See 'Initial treatment' below and "Croup: Pharmacologic
and supportive interventions".)
The approach to the management of croup will be
discussed below. The clinical features and evaluation of
croup, and the evidence supporting the use of the
pharmacologic and supportive interventions included
below are discussed separately. (See "Croup: Clinical
features,
evaluation,
and
diagnosis" and "Croup:
Pharmacologic and supportive interventions".)
Fatigue
Worsening course
Suprasternal retractions
Fever (>38.5C)
Prolonged symptoms (longer than seven days)
Racemic epinephrine is
administered
as
0.05 mL/kg per dose (maximum of 0.5 mL) of a 2.25
percent solution diluted to 3 mL total volume with
normal saline. It is given via nebulizer over 15
minutes.
L-epinephrine is administered as 0.5 mL/kg per
dose (maximum of 5 mL) of a 1:1000 dilution. It is
given via nebulizer over 15 minutes.
The benefits of nebulized epinephrine have been
demonstrated in a meta-analysis of eight trials that found
improvement in croup score 30 minutes post-treatment
and shorter hospital stay; there was no difference in
effectiveness between racemic epinephrine and Lepinephrine [13]. (See "Croup: Pharmacologic and
supportive interventions", section on 'Nebulized
epinephrine'.)
Observation and disposition Patients should be
observed for three to four hours after initial treatment.
The need for additional intervention and/or admission to
the hospital is determined chiefly by the response to
therapy with corticosteroids and nebulized epinephrine.
The majority of children with moderate croup have
symptomatic improvement after treatment with nebulized
epinephrine and corticosteroids and can be discharged
home, whereas those with severe symptoms on
presentation are more likely to require hospitalization.
No stridor at rest
Normal pulse oximetry
Good air exchange
Normal color
Normal level of consciousness
Demonstrated ability to tolerate fluids by mouth
failure
requiring
endotracheal
Normal color
Normal level of consciousness
Demonstrated ability to tolerate fluids by mouth
Atypical course Children admitted for croup typically
remain in the hospital for less than 36 hours [24]. The
child who does not show improvement as expected (over
the course of one to two days) may have an underlying
airway abnormality or may be developing a complication
of croup. Further evaluation with radiographs of the soft
tissues of the neck, or consultation with otolaryngology,
may be warranted. A biphasic illness with poor response
to nebulized epinephrine in conjunction with high fever
and toxic appearance should prompt consideration of
bacterial tracheitis (picture 1) [2]. (See "Croup: Clinical
features, evaluation, and diagnosis", section on
'Differential
diagnosis' and "Bacterial
tracheitis
in
children: Clinical features and diagnosis".)
FOLLOW-UP Any patient who was admitted to the
hospital, received nebulized epinephrine, or had a
prolonged outpatient visit should have follow-up
scheduled with the primary care provider within 24 hours
or as soon as can be arranged. Although some children
may continue to have mild to moderate symptoms at the
time of follow-up, there are no studies that support the
routine use of corticosteroid therapy beyond 24 hours.
Follow-up should continue until the child's symptoms
have begun to resolve. The child whose symptoms do
not resolve over the course of approximately seven days
may have an underlying airway abnormality or may be
developing a complication of croup. (See 'Atypical
course' above.)
PROGNOSIS Symptoms of croup resolve in most
children within three days, but may persist for up to one
week [27,28]. Approximately 8 to 15 percent of children
with croup require hospital admission [20,29], and among
those, less than 1 percent require intubation [23].
Mortality is rare, occurring in <0.5 percent of intubated
children [30].
Complications Complications
of
croup
are
uncommon. Children with moderate to severe croup are
at risk for hypoxemia (oxygen saturation <92 percent in
room air) and respiratory failure. Other complications
include
pulmonary edema,
pneumothorax,
and
pneumomediastinum [31]. These complications can be
anticipated and managed by aggressive monitoring and
intervention in the medical setting. Out-of-hospital cardiac
arrest and death also have been reported [32].
Beyond
the
Basics
topics
(see "Patient
information: Croup in infants and children (Beyond
the Basics)")
SUMMARY AND RECOMMENDATIONS
Children with croup should be seen in the office or
emergency department if they have stridor at rest,
an underlying airway abnormality, previous
episodes of moderate to severe croup, underlying
conditions that may predispose to respiratory
failure, rapid progression of symptoms, inability to
tolerate fluids, prolonged symptoms, or an atypical
course. (See 'Telephone triage' above.)
Children with mild symptoms (ie, no stridor at rest
and no respiratory distress) can be managed at
home. Families should be instructed in provision of
supportive care and indications to seek medical
attention. (See 'Home treatment' above.)
We
suggest
that
a
single
dose
of
oral dexamethasone (0.6 mg/kg) be used when
electing to treat children with mild croup who are
seen in the outpatient setting (algorithm 1) (Grade
2A). (See 'Outpatient treatment' above and "Croup:
Pharmacologic and supportive interventions",
section on 'Dexamethasone'.)
Children with moderate croup (ie, stridor at rest
with mild to moderate retractions) should be
evaluated in the office or emergency department,
and those with severe croup (stridor at rest with
marked retractions and significant distress or
agitation) should be evaluated in the emergency
department (table 1). Children with severe croup
must be approached cautiously, as any increase in
anxiety
may
worsen
airway
obstruction.
(See 'Moderate to severe croup' above.)
We recommend that children with moderate to
severe croup be treated with a single dose
of dexamethasone (0.6 mg/kg, maximum of 10 mg)
by the least invasive route (algorithm 1) (Grade
1A). (See 'Initial treatment' above and "Croup:
Pharmacologic and supportive interventions",
section on 'Glucocorticoids'.)
We recommend that children with moderate to
severe
croup
be
treated
with
nebulized epinephrine (Grade 1A) in addition
to dexamethasone (algorithm
1).
(See'Initial
treatment' above and "Croup: Pharmacologic and
supportive interventions", section on 'Nebulized
epinephrine'.)
Racemic epinephrine is
administered
as
0.05 mL/kg per dose (maximum of 0.5 mL) of
a 2.25 percent solution diluted to 3 mL total
volume with normal saline. It is given via
nebulizer over 15 minutes.
L-epinephrine is
administered
as
0.5 mL/kg per dose (maximum of 5 mL) of a
1:1000 dilution. It is given via nebulizer over
15 minutes.
Nebulized epinephrine can be repeated every 15 to
20 minutes. The administration of three or more
doses within a two- to three-hour time period should
prompt initiation of close cardiac monitoring if this is
not already underway.
Children with moderate to severe croup should be
observed for three to four hours after intervention.
Those who improve may be discharged home.
Children with persistent or worsening symptoms
during the observation period should be admitted to
the hospital. (See 'Discharge to home' above
and 'Indications for hospital admission' above.)
Management of children hospitalized for croup
includes:
Supportive care with provision of intravenous
fluids and fever reduction. (See 'Supportive
care' above.)
Respiratory care with repeated doses
nebulized epinephrine,
as
indicated
respiratory distress, and administration
humidified air or oxygen, as indicated
hypoxemia. (See 'Respiratory care' above.)
of
by
of
by
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
Editor
Editor
Disclosures: Charles R Woods, MD, MS Other Financial Interest: Cerexa [Epiglottitis (Data Safety Monitoring Board for pediatric trials of the
antibiotic agent ceftaroline)]. Sheldon L Kaplan, MDGrant/Research/Clinical Trial Support: Pfizer [vaccine (PCV13)]; Forest Lab [antibiotic
(Ceftaroline)]; Optimer [antibiotic (fidaxomicin)]. Consultant/Advisory Boards: Pfizer [vaccine (PCV13)]. Carrie Armsby, MD, MPH Nothing to
disclose.
Contributor disclosures are reviewed for conflicts of interest by the editorial group. When found, these are addressed by vetting through a multilevel review process, and through requirements for references to be provided to support the content. Appropriately referenced content is
required of all authors and must conform to UpToDate standards of evidence.
Conflict of interest policy
All topics are updated as new evidence becomes available and our peer review process is complete.
Literature review current through: Jul 2015. | This topic last updated: Jan 30, 2014.
INTRODUCTION Croup (laryngotracheitis) is a
respiratory illness characterized by inspiratory stridor,
barking cough, and hoarseness. It typically occurs in
children six months to three years of age and is caused
by parainfluenza virus. (See "Croup: Clinical features,
evaluation, and diagnosis".)
The treatment of croup has changed significantly since
the
1980s.
Glucocorticoids
and
nebulized epinephrine have become the cornerstones of
therapy. Substantial clinical evidence supports the
efficacy of these interventions [1-5]. The impact also is
evident in the decrease in annual hospital admissions for
croup in children in the United States between 1979 to
1982 and 1994 to 1997 (from 2.8 to 2.1 per 1000 for
children <1 year and from 1.8 to 1.2 per 1000 children
for children 1 to 4 years) [6].
Treatment of croup may involve a variety of
pharmacologic and nonpharmacologic interventions. It
may occur entirely at home, or in the office, emergency
department (ED), or hospital setting. Supportive and
pharmacologic interventions will be discussed below.
The clinical features and evaluation of croup and the
approach to management are discussed separately.
(See "Croup: Clinical features, evaluation, and
diagnosis" and "Croup: Approach to management".)
GLUCOCORTICOIDS Glucocorticoids provide longlasting and effective treatment of mild, moderate, and
severe croup [3,7-9]. The antiinflammatory actions of
glucocorticoids are thought to decrease edema in the
laryngeal mucosa of children with croup. Improvement is
usually evident within six hours of administration but
seldom is dramatic [7,10].
be
equally
effective.
epinephrine' above.)
(See 'Nebulized