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Volume Therapy
Gelofusine
Worldwide tried and tested
Gelofusine is a colloidal volume replacement fluid based on
4% modified fluid gelatin.
Several decades of experience in production and use of modified
fluid gelatins recommend B. Braun as the partner of choice in
the field of volume therapy.
Over the years, B. Braun has put together an impressive track
record with Gelofusine with proven pharmaceutical quality
and demonstrated therapeutical value.
Important advantages in comparison with other gelatins make
Gelofusine the most often used gelatin for modern volume
therapy.
Polypeptide chains of
succinylated gelatin with strong
negative charge repel one another
Gelofusine (G) 4%
modified fluid gelatin
Voluven (V) 6% HES 130/0.4
Saline (S)
600
500
400
300
200
100
0
0.4
COP50/COP10 ratio
[ml] 700
5
6
Time [hours]
Fig. 2: Changes in blood volume and extravascular fluid volume after infusion of
1 litre of 0.9% saline (S), 4% modified fluid gelatin (G) and 6% HES 130 (V)
over 1 hour 1.
p values S vs G < 0.0001; S vs V < 0.0001; G vs V = 0.70
0.3
0.2
0.1
Urea-linked
Gelatin
Human
Albumin
Gelofusine
Fig. 3: COP50 /COP10 ratios (as indicator for plasma retention). Adapted from3.
Voume Therapy
7.4 0.3
n
274
100%
4 hours
Gelofusine
Composition
1000 ml solution contain:
Succinylated gelatin
(= modified fluid gelatin)
Therapeutic Indications
Colloidal plasma volume substitute for
40.00 g
(Molecular weight,
weight average:
30.000 Dalton
Molecular weight,
number average: 23.200 Dalton)
Sodium chloride
7.01 g
Electrolyte concentrations
Sodium
154 mmol/l
Chloride
120 mmol/l
Theoretical osmolarity: 274 mOsm/I
pH:
7.4 0.3
1. Lobo DN:
Effect of volume loading with 1 liter intravenous infusions of 0.9%
saline, 4% succinylated gelatine (Gelofusine) and 6% hydroxyethyl starch
(Voluven) on blood volume and endocrine responses: a randomized, three-way
crossover study in healthy volunteers.
Crit Care Med. 2010 Feb; 38(2): 464-70
4. Wilkes N J et al.:
The effects of balanced versus saline-based hetastarch and crystalloid
solutions on acid-base and electrolyte status and gastric mucosal perfusion
in elderly surgical patients
Anesth Analg 93 (2001) 811-816
2. Himpe D et al.:
Priming solutions for cardiopulmonary bypass: comparison of three colloids
Cardiothorac Vasc Anesth 5 (1991) 457-466
, Gelafundina
Undesirable Effects
After the administration of Gelofusine infusions,
just as of any colloidal volume substitutes, anaphylactoid reactions of varying degrees of severity
may occur.
5. Williams E L et al.:
The effect of intravenous Lactated Ringers solution versus 0.9% sodium
chloride solution on serum osmolarity in human volunteers
Anesth Analg 88 (1999) 999-1003
3. Webb A R et al.:
In vitro colloid osmotic pressure of commonly used plasma expanders
and substitutes: a study of the diffusibility of colloid molecules
Intensive Care Med 15 (1989) 116-120