GENReports: Market & Tech Analysis

Single,Cell,Analysis,(SCA):,
Expanding,in,Importance,in,
Life,Science,Research,,
circa,2015,
> Gary Oosta, Ph.D.
Biotechnology Analyst,
Select Biosciences, Inc.

GENengnews.com,

> Enal Razvi, Ph.D.

Managing Director
Select Biosciences, Inc.
E-mail: enal@selectbio.us
Twitter: @enalrazvi!

GENReports:,Market,&,Tech,Analysis,!Produced!by!Oosta!and!Razvi!!2015,

Single,Cell,Analysis,(SCA),in,the,Life,Sciences,
Marketplace,Analyzed,from,the,BoNomOUp,

Scope,of,this,Report:!
! There!is!the!unmet!need!to!characterize!the!dynamics!of!the!single!cell!
analysis!in!the!life!sciences!marketplace!since!such!an!analysis!will!provide!an!
en#bloc#view!of!the!eld!which!is!known!to!be!amorphous!as!it!impact!many!
dierent!applicaEon!areas!
! Given!the!nascent!nature!of!this!eld,!we!believe!that!an!excellent!means!to!
analyze!this!space!is!to!view!the!enEre!body!of!academic!literature!published!
in!this!eld!!in!this!manner,!viewing!the!niches!that!are!currently!expanding!
as!well!as!technologies/methodologies!driving!the!space!forward!
! We,analyzed,28,401,publicaVons,in,total,that,together,consVtute,the,bulk,of,
the,academic,literature,in,this,eld,at,the,present,Vme,(August,2015),
! These,publicaVons,represent,the,period,2010"2015YTD,and,therefore,represent,the,most,
recent,5Oyears,of,publicaVon,acVvity,in,this,eld,
! The,analysis,presented,in,this,report,are,based,on,Single,Cell,AnalysisOfocused,publicaVons,
from,this,period,2010"2015YTD,
GENengnews.com,

GENReports:,Market,&,Tech,Analysis,!Produced!by!Oosta!and!Razvi!!2015,

Data,Mining,and,Technology,AnalyVcs,Reveal,
Technology,and,Market,Trends,in,SCA,
Broad!!Search!

Comprehensive!
Database:!!
28,401,papers,on,SCA,
Categorize!and!Segment!

MarkeEng!
Research!

+!

Experience!

from!past!projects!

+!

using!
Literature!&!
Process!Flow!Charts!

+!

Text!
Clustering!

850!Segments,!Categories!&!Model!!
(Keywords/Phrases)!

Hotspot!Map!

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Graphs!

+!

Adjacent!Word!

keyword!expansion!

The!
Model!

Tables!
Rank
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19

segment
EXOSOME
OCCULT.&.CANCER
GYNECOLOGIC.&.CANCER
AMYOTROPHIC.LATERAL.SCLEROSIS
CLOSTRIDIUM.DIFFICILE
ADENOCARCINOMA.&.CANCER
FACTOR.VIII
MYOBLAST
ROTAVIRUS,.REOVIRUS
SCREEN&PRINT
GLIOBLASTOMA.&.CANCER
AST/SGOT
CORTISOL
HEAD?AND?NECK.&.CANCER
LIVER.TRANSPLANT
PARKINSON'S,.PARKINSONS,.GAIT.DISORDER
PAPER+BASED
SOFT.TISSUE.&.CANCER
OVARIAN.&.CANCER

new+vp+val
1.000
1.000
0.890
0.854
0.854
0.835
0.781
0.781
0.781
0.755
0.711
0.676
0.676
0.676
0.676
0.676
0.674
0.660
0.656

Reveals!Trends!
from!the!
BoWomXUp!

GENReports:,Market,&,Tech,Analysis,!Produced!by!Oosta!and!Razvi!!2015,

Single,Cell,Analysis,Database,from,PubMed,has,28,401,papers,in,the,
period,2010"2015YTD.,
The,Word,Cloud,from,Vtles,hints,at,the,topics,found,in,these,papers.,

GENengnews.com,

GENReports:,Market,&,Tech,Analysis,!Produced!by!Oosta!and!Razvi!!2015,

Single,Cell,Analysis,Papers,from,PubMed,

To,see,the,most,recent,developments,more,clearly,,we,analyzed,publicaVons,
from,2010"2015YTD,[highlighted,in,Red],

Year,of,PublicaVon,
GENengnews.com,

GENReports:,Market,&,Tech,Analysis,!Produced!by!Oosta!and!Razvi!!2015,

Fluorescence,is,the,Dominant,enabling,technology,in,SCA,,
but,noVce,the,Upsurge,in,Mass,Spectrometry,Recently,

GENengnews.com,

GENReports:,Market,&,Tech,Analysis,!Produced!by!Oosta!and!Razvi!!2015,

Imaging,methods,are,important,to,SCA.,,,Flow,cytometry,is,a,
Growth,Area.,,An,InteresVng,new,Area,is,Molecular,LocalizaVon,
Microscopy,

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GENReports:,Market,&,Tech,Analysis,!Produced!by!Oosta!and!Razvi!!2015,

Microuidics,for,SCA,is,Expanding,",A,Very,Clear,
Trend,

GENReports:,Market,&,Tech,Analysis,!Produced!by!Oosta!and!Razvi!!2015,
The,Use,of,Microuidics,for,Single,Cell,Capture,and,Analyses:,
An,Important,and,Growing,Space,

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PCR,and,qPCR,are,the,dominant,assay,type,in,SCA",InterrogaVon,
of,SCA,Nucleic,Acid,Cargo,,
IsolaVon,Methods,are,Quite,Limited,Currently,

GENengnews.com,

GENReports:,Market,&,Tech,Analysis,!Produced!by!Oosta!and!Razvi!!2015,

Arrays/Microarrays,Have,Penetrance,in,the,SCA,Space,as,Means,
of,Studying,Known,GeneVc,Elements,in,Material,from,Single,
Cells,

GENengnews.com,

GENReports:,Market,&,Tech,Analysis,!Produced!by!Oosta!and!Razvi!!2015,

A,Variety,of,Cells,and,Tissues,are,MenVoned,in,the,SCA,Database,",This,
suggests,a,Heterogeneous,Set,of,Samples/StarVng,Materials,used,in,SCA,
Studies,

GENengnews.com,

GENReports:,Market,&,Tech,Analysis,!Produced!by!Oosta!and!Razvi!!2015,

SCA,intersects,Many,Standard,and,Growth,Technologies.,,NoVce,
the,Rapid,Growth,of,CirculaVng,Tumor,Cells,(CTCs),in,the,SCA,
Space,

CTCs,
These,S
paces,N
by,SCA, ot,Impacted,
Current
ly,

GENengnews.com,

GENReports:,Market,&,Tech,Analysis,!Produced!by!Oosta!and!Razvi!!2015,

SCA,is,an,Expanding,Field,
Growth,is,Driven,by,MulVple,Spaces!
SCA,publicaVons,grew,at,a,CAGR,of,7.3%,over,the,last,six,
years.,,,The,growth,rate,is,nearly,linear.,
Cancer,,geneVcs/genomics,,DNA,,polymorphisms,and,
imaging,are,among,the,larger,segments.,,These,areas,sustain,
growth,in,SCA.,
Larger,NEW,growth,drivers,(newly,emerging,areas,to,watch),
include,NGS,,RNA,sequencing,,and,biomarkers,spaces,
represenVng,the,impact,of,SCA,into,the,diagnosVcs,arena,
The,growth,of,CTCs,in,the,context,of,SCA,demonstrates,the,
deployment,of,SCA,technologies,and,approaches,in,the,
cancer,diagnosVcs,space,
In,terms,of,methodologies,,both,nucleic,acid,analyses,as,well,
as,mass,spectrometry,(for,protein,analyses),are,an,
expanding,theme,in,the,SCA,eld,
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GENReports:,Market,&,Tech,Analysis,!Produced!by!Oosta!and!Razvi!!2015,

This,Select,Biosciences,Conference,Brings,Together,the,Key,Opinion,Leaders,
and,all,the,Stakeholders,in,these,Spaces,as,they,Converge,
For!More!Details!on!the!
Conference,!Please!Visit:!

hNp://bit.ly/1IGAK81,

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Or!Scan!the!Following!QR!Code!
with!your!Mobile!Device!(iPhone,!
iPad,!Android],

GENReports:,Market,&,Tech,Analysis,!Produced!by!Oosta!and!Razvi!!2015,