Diagrams:

Diagram I
Pathogenesis of Insulin Dependent DM (Type 1)
Genetic Predisposition (Susceptibility)

Environmental
insult

Autoimmunity
-Lymphocyte
infiltration
-Insulitis

- Viral infection
- Toxic chemical
agents

Immunologic Response
-

Islet cell antibodies

Cell- mediated immunity

cell destruction

Lack of insulin release

Insulin Dependent Diabetes Mellitus (IDDM)

Diagram II
Pathogenesis of Non- Insulin Dependent DM (Type 2)
Hereditary
Factors

Obesity

Delayed or insufficient insulin

secretion

Insulin resistance (Receptor

defect or other events)

Increased insulin demand

cell exhaustion and dysfunction

Impaired secretion
of insulin

Hyperglycemia

Non- Insulin Dependent DM (NIDDM)