Beruflich Dokumente
Kultur Dokumente
K.SANJEEV KIRAN
13080040
LALITHA COLLEGE OF PHARMACY
TABLET COATING
CONT..
The core contains a substance
which is incompatible in the
presence of the light and subject
atmospheric oxidation.
The core is inelegant.
The active substance is colored and
migrates easily to stain hands and clothes.
Coating can modify the drug release
profile. E.g., enteric coating, pulsatile
delivery.
Sugar coating
Film coating
Enteric coating
Controlled release coating
Specialized coating
Compressed coating
Electrostatic coating
Dip coating
Vacuum film coating
SUGAR COATING
sugar coating is a multistep
process.
Its use of labour is more, require
a fair degree of skill.
In suitable sugar-coating
equipment the tablet cores are
successively treated with aqueous
sucrose solutions which,
depending on the stage of coating
reached, may contain other
functional ingredients,e.g.
fillers, colors, etc.
ADVANTAGES OF S.C
Constituent raw materials are
widely acceptedno regulatory
problems.
No complex equipment or
services are required.
For high humidity climates, it
generally offers a stability
advantage over film-coated
tablets.
1.
CONT
3. SMOOTHING
Additional smoothing prior to color
coating can also be applied to opacify the
subcoat to promote a brighter final color
4. COLORING
The most critical step of sugar coating,
consists of multi-step application of syrup
containing the required
color(dye/pigment)
CONT
5. POLISHING
Imparts the required gloss to the final
product.
FILM COATING
Film coating is a thin polymer-based coat applied to
a solid dosage form.
The thickness of such a coating is usually between
20 and 100 m.
Each and every tablet is passed through a spray
zone, where the adherent material is sprayed and
allowed to dry before the next portion of coating
and this process is repeated number of times.
FORMULATION
POLYMERS
The vast majority of the
polymers used in film coating
are either cellulose derivatives,
such as the cellulose ethers, or
acrylic polymers and
copolymers.
Basically there are two classes
of such
material depending upon the
method of preparation; true
latexes and pseudolatexes.
POLYMER CHARACTERISTICS
Solubility
Viscosity
Permeability
Mechanical properties
Tackiness
PLASTICIZERS
Plasticizers are simply relatively
low molecular weight materials
which have the capacity to alter
the physical properties of a
polymer to render it more useful
in performing its function as a
film-coating material.
There are often chemical
similarities between a polymer.
CONT
1. Polyols
(a) glycerol (glycerin);
(b) propylene glycol;
(c) polyethylene glycols PEG (generally the 2006000 grades).
2. Organic esters
(a) phthalate esters (diethyl, dibutyl);
(b) dibutyl sebacete;
(c) citrate esters (triethyl, acetyl triethyl, acetyl tributyl);
(d) triacetin.
3. Oils/glycerides
(a) castor oil;
(b) acetylated monoglycerides;
(c) fractionated coconut oil.
COLOURANTS
CONT.
Inorganic colors
Titanium dioxide
Iron oxide yellow, red and black
Talc.
Natural colors
Riboflavine
Carmine
Anthocyanins
SOLVENTS/VEHICLES
water
alcohols
ketones
esters
chlorinated hydrocarbons.
ENTERIC COATING
An enteric coating is a
barrier applied to oral
medication that controls the
location in the digestive
system where it is absorbed.
Enteric refers to the small
intestine, therefore enteric
coatings prevent release of
medication before it reaches
the small intestine.
Composition of coatings
Specialized coating
Electrostatic coating
Electrostatic coating is a
manufacturing process that employs
charged particles to more efficiently
coat a tablet.
Dip coating
CONT.
Vacuum film coating
CONT.
Essentially no color, odor or taste.
Compatibility with common coating
solution additives.
Nontoxic and ease of application.
Resistance to cracking and should act as
barrier.
Ease of printing procedure on high speed
equipment
1.
EMULSION-SOLVENT EVAPORATION
2.
PHASE INVERSION
EMULSION-SOLVENT EVAPORATION
PHASE INVERSION
Polymers and plasticizer first undergoes
hot melting or solvent gelation and
combined with long chain fatty acids to
form a homogenous mixture.
A dil Alkali solution is slowly added to the
mixture under vigorous agitation to form
initially a w/o type of emulsion (water in
polymer)
As more aqueous alkali is added, phase
inversion occurs and a dispersion of
polymers in water is produced
COATING DEFECTS
BRIDGING
CAPPING
This is when the
tablet separates in
laminar fashion. This
occurs due to
improper tablet
compression
EROSION
This can be the result
of soft tablets, an
over wetted tablet
surface, inadequate
drying or lack of
tablet surface
strength
TWINNING
CHIPPING
This is the result of high
pan speed, a friable tablet
core or a coating solution
that lacks plastizer.
MOTTLED COLOR
Happens when coating
solution is improperly
prepared, the actual spray
rate differs from target rate.
TABLET QUALITY
SPRAY GUN
CALIBRATION
GUN NOZZLES
PAN LOADING