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Course code
BIO 310
Course Title
Biostatistics
Credits:
Course Coordinator
Ramana Athreya
Nature of Course
Pre requisites
None.
Objectives
Course contents
Topics
1. Statistical measures
2. Probability: Basic concepts, distribution functions, change
of variables;
3. Fitting data: fitting functions, goodness of fit, correlation,
regression, smoothing, interpolation, extrapolation
4. Statistical tests: Parametric and non-parametric tests, null
hypothesis, statistical significance, confidence intervals,
Type I and II errors, ANOVA, multiple testing
5. Time series analysis: Correlation, periodicity
The fortnightly interaction includes 4 hours of lectures, and 2
hours of hands-on experience of using the R statistical package
Evaluation /assessment
a. Mid-sem examination 35 %
b. End-sem examination 35%
c. Assignments/quizzes 30%
10
Suggested readings
Course code
BIO 311
2
3
Course Title
Credits
Hrs
3
7
10
6
8
4
5
6
7
Course Coordinator
Nature of Course
Pre requisites
Objectives (goals, type of
students for whom useful,
outcome etc)
Course contents
(details of topics with no
of lectures for each)
Evaluation /assessment
10
Suggested readings
(with full list of authors,
publisher, year, edn etc.)
Course code
BIO 313
2
3
Course Title
Credits
5
6
7
L- lectures alone
None
This course helps to provide fundamental concepts from the enormous
and ever-growing field of Molecular Biology to Undergraduate students.
This course will help students to have a sound knowledge of molecular
biology, which will also enable them to carry out research using
molecular biology techniques.
8
Course contents
(1) Diversity of Genomes (2)
(details of topics /sections
(2) Maintenance of the Genome (18)
with no. of lectures for
each)
- DNA, Chromosomes and Genome
- Replication of DNA
- The Mutability and Repair of DNA
- Homologous Recombination at the Molecular Level
(3) Expression of the Genome (10)
- Mechanisms of Transcription
- RNA Splicing- Translation
4) Techniques in Molecular Biology (10)
- Molecular Cloning methods
- Molecular Tools for Studying Genes and Gene Activity
Evaluation /assessment
a. End-sem examination- 30 %
b. Mid-sem examination- 30 %
c. Quiz- 40 %
10
Suggested readings
(with full list of authors,
publisher, year, edn etc.)
Text Book(s)
1. Molecular Biology of the Gene by Watson, Baker, Levine, Losick et al.
[2007] 6 Ed. Benjamin Cummings
2. Principles of Gene Manipulation by Primrose, Twyman, Old [2002] 6
Ed. Wiley-Blackwell
3. Molecular Biology by Weaver [2011] 5 Ed. McGraw- Hill Science.
4. Molecular Biology and Genomics by Mulhardt [2006] 1 Ed. Elsevier.
Course code
BIO 314
2
3
Course Title
Credits
Bioinformatics
4
5
6
7
MS Madhusudhan*
Course contents
(details of topics /sections
with no. of lectures for
each)
Evaluation /assessment
10
Suggested readings
(with full list of authors,
publisher, year, edn etc.)
Text Book(s)
1. R. Durbin, S. R. Eddy, A. Krogh, and G. Mitchison, Biological Sequence
Analysis: Probabilistic Models of Proteins and Nucleic Acids (Cambridge
University Press, 1999), ISBN 0521629713
2. Arthur Lesk, Introduction to Bioinformatics (Oxford University Press,
2008), ISBN-10: 0199208042 ISBN-13: 978-0199208043
3. Arthur Lesk, Introduction to Protein Science : Architecture, function
Course code
BIO 320
2
3
Course Title
Credits
Genetics
4
5
6
7
Course contents
Section #1 (Lecture Topics)
(details of topics /sections
i) Mendelian Genetics. 3 lectures week 1
with no. of lectures for
each)
ii) Non-Mendelian Genetics: Linkage, Incomplete Dominance, Maternal
Inheritance, Extra-nuclear inheritance, Sex-linked inheritance, Sex
determination, Dosage Compensation, Epigenetics, Genomic imprinting.
3 lectures week 2
iii) The Chromosomal basis of inheritance. 2 lectures
10
Evaluation /assessment
Suggested readings
(with full list of authors,
publisher, year, edn etc.)
End-sem examination- 25 %
Mid-sem examination- 25 %
Quiz- 20 %
Text Book(s)
(i)Introduction to Genetic Analysis Griffiths, AJ et. al. , 2008, 9
Edition. WH Freeman & Co. New York.
th
Course code
BIO 322
2
3
Course Title
Credits
Biophysics-I (NKN)
4
Objectives (goals, type of This course will introduce the exciting new interdisciplinary field of
students for whom useful, Physical Biology of the Cell. It will introduce the student to the physical
outcome etc)
concepts used to study biology. Given the diversity of the chemical
entities and results of high-throughput genomic, proteomic and postgenomic studies, the need for theories that allow a unification of
biological phenomena has been recognized as being critical. We begin
with order of magnitudes in biophysics. This will set the stage for models
from classical mechanics and their application to processes ranging from
molecules, to tissues. The role of biophysical techniques in quantification
of cell and molecular systems will be addressed- both from the
perspective of the underlying physics as well as the insights obtained in
biology. Demonstration labs on measurement of cells- size, dynamics,
forces and diffusion will be used to generate data that the students are
expected to evaluate, interpret and report the results using SciPy
(scientific python). Reports are due no later than 1 week after the lab,
with specific deadlines being announced in advance. Assignments will be
provided throughout the course. Self-learning will be evaluated through
the evaluation of reading of papers by students and their presentation.
Labs, assignments and presentations will constitute the major part of the
continuous assessment over and above the mid- and end- semester
exams.
Course contents
(details of topics /sections
with no. of lectures for
each)
Evaluation /assessment
a. End-sem examination- 25 %
b. Mid-sem examination- 25%
c. Quizzes, Reading-projects, Group-work - 30%
d. Assignments- 20 %
10
Suggested readings
(with full list of authors,
publisher, year, edn etc.)
Text Book(s)
Nelson, P. (2003) Biological Physics: Energy, Information, Life. Freeman
Philips, R., Kondev, J., Theriot, J. (2008) Physical Biology of the Cell.
Garland Sciences.
Mechanics of the Cell (2002) Boal. Cambridge Univ. Press.
Course code
BIO 410
2
3
Course Title
Credits
Advanced Biochemistry I
4
5
6
L- lectures alone
No prerequisites.This course is a prerequisite for Advanced Biochemistry
II (BIO 417)
7
Objectives (goals, type of The course aims at introducing advanced concepts in biochemistry and
students for whom useful, provides a framework to understand basic biomolecular function. It
outcome etc)
introduces the principles of thermodynamics as they apply to biological
systems and lays special emphasis on studying enzymes as biological
catalysts; a universal prerequisite for the very existence of all life. It also
deals with routine and advanced methodologies used in generating and
analyzing biochemical data.
This course is essentially meant to help understand biology from the
point of view of molecules and physicochemical principles.
Evaluation /assessment
a. End-sem examination- 30 %
b. Mid-sem examination- 30 %
c. Quiz/Paper discussions- 40 %
10
Suggested readings
(with full list of authors,
publisher, year, edn etc.)
Text Book(s)
Biochemistry Voet, D., Voet, J.G. Publisher: Wiley; 3 edition
Lehninger Principles of Biochemistry David L. Nelson, Michael M. Cox.
Publisher: W. H. Freeman, Fourth Edition
Jeremy M Berg; John Tymoczko; Lubert Stryer (2012), Biochemistry,
th th
7 /6 edition (or older), Wiley.
Segels Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and
Course code
BIO 411
2
3
Course Title
Credits
Ecology I
4
Course Coordinator
Deepak Barua*
5
6
7
Nature of Course
Pre requisites
Objectives
L- lectures alone
None
This course will cover the basic theoretical framework of ecology, and
deal with some of the topics that were introduced in Bio 201 (Ecology
and Evolution) in greater detail
Course contents
Introduction (4 lectures)
Definition of Ecology; Hierarchical levels of biological organization;
Philosophy of the Science of Ecology; Complexity in Nature; History of
Ecological thought; Significance of Ecology; Evolution by Natural
Selection
I. Ecology of Individual Organisms (8 lectures)
Physiological ecology: conditions vs. resources, niche, tolerance range,
optima, acclimation, limiting factors, energy balance, photosynthesis,
respiration, storage, growth, reproduction, abiotic factors: temperature,
moisture, light, soil, fire, nutrients
II. Population Ecology (10 lectures)
Population growth and regulation: What is a population, birth rate, death
rate, life tables, survivorship curves, population growth functions,
carrying capacity, population pyramids; Evolution of life histories: r and K
selection, iteroparous vs. semelparous reproduction, Ageing and
senescence, tradeoffs; Species interactions: competition, mutualism,
herbivory, predation, optimal foraging, parasitism, trophic cascades
III. Community Ecology (8 lectures)
Community structure: emergent properties, dominance, diversity, spatial
structure, assembly rules; Community change: disturbance, succession,
climax, phenology, seasonal patterns
IV. Ecosystem Ecology (8 lectures)
Evaluation /assessment
a. End-sem examination- 30 %
b. Mid-sem examination- 30 %
c. Assignments/discussion/participation/term paper 40 %
10
Suggested readings
a. Begon, M., Townsend, CR, and Harper, JL. (2005) Ecology - From
Individuals to Ecosystems. 4th Ed. Blackwell Publishing.
b. Ricklefs RE and Miller GL (2000). Ecology. 4th Ed. Freeman and
Co.
c. Gurevitch J, Schener SM, and Fox GA (2006). The Ecology of
Plants. 2nd Ed. Sinaeur and Associates.
Course code
BIO 334
2
3
Course Title
Credits
Neurobiology I
3
5
6
7
L- lectures alone
None
The course posits neuroscience as a specialized discipline. The
overarching goal of the course is to provide a detailed description of the
logic of the nervous system from the perspectives of evolution,
organization, development, physiology and emergent properties like
learning and memory. The course is aimed at students interested in
understanding the fundamental basis of the neural function and output
and those interested in pursuing neuroscience in the future.
Course contents
Membrane channels, ionic basis of resting potential and action potential
(details of topics /sections (5 Lectures)
with no. of lectures for
Diversity in biophysical properties of ion channels and its effects on
each)
membrane excitability (2)
Propagation of action potential and Synaptic transmission (2 Lectures)
Evaluation /assessment
10
Suggested readings
(with full list of authors,
publisher, year, edn etc.)
Text Book(s)
th
i) E. Kandel, et al. (2000). Principles of Neural Science, 4 Ed. McGrawHill Medical
ii) M. Bear, et al (2006). Neuroscience. 3
Wilkins
rd
iii) D. Sanes, et al. (2005). Development of the Nervous System. 2nd Ed.
Academic Press
1
Course code
BIO 431
2
3
Course Title
Credits
Epigenetics
3
Sanjeev Galande*
5
6
L- lectures alone
None (preferred: Biochemistry/Genetics/Cell and Molecular Biology)
Objectives (goals, type of To introduce students to basics concepts in gene regulation, chromatin
students for whom useful, biology, genome-environment interaction, epigenetics and its
outcome etc)
applications in genomics and disease biology. The course would be useful
for the students who are interested in learning about the organization of
genes and their organization at molecular level and also using a systems
approach. The discussions will encompass biochemistry, bioinformatics,
genomics, proteomics, computational biology and systems biology.
Course contents
Mapping and sequencing of genomes from large number of
(details of topics /sections evolutionarily diverse species in the past decade revealed that sequence
with no. of lectures for
per se is not sufficient to understand genome function, the higher-order
each)
Evaluation /assessment
a. End-sem examination- 30 %
b. Mid-sem examination- 30 %
c. Quiz- 10 %
d. Wrtitten essay assignment/paper presentation 20 %
10
Suggested readings
(with full list of authors,
publisher, year, edn etc.)
Course code
BIO 454
2
3
Course Title
Credits
Structural Biology
3
5
6
7
L- lectures alone
None
The course provides an introduction to the structure of biomolecules
with emphasis on the techniques used for structure determination and
analysis. The course covers basic aspects of sample preparation,
structure determination and structure analysis. The aim of the course is
to introduce students to the process involved in structure determination
and analysis, and how structural information can be utilized for better
understanding of biological processes. The course is for V and VII
semester students.
Course contents
Introduction to structures of biomolecules: proteins and nucleic acids
(details of topics /sections
Recombinant technology and purification techniques to isolate
with no. of lectures for
biomolecules
each)
Determination of atomic structure using X-ray crystallography
Studying macromolecular assembly using electron microscopy
Biophysical and spectroscopic techniques to understand
structuresGraphics tools to visualize and analyze atomic structure of
biomolecules.
Understanding biological process through structures: snippets from
protein translation
Evaluation /assessment
a. End-sem examination- 35 %
b. Mid-sem examination- 35 %
c. Quiz- 15 %
d. Assignments- 15 %
10
Suggested readings
(with full list of authors,
publisher, year, edn etc.)
Course code
BIO 452
2
3
Course Title
Credits
Plant Biology II
3
Anjan Banerjee*
5
6
7
History of plant cell culture. Various methods of Plant Cell Tissue and
Course contents
(details of topics /sections Organ Culture, direct and indirect organogenesis, somatic
with no. of lectures for
embryogenesis, micropropagation (5 L)
each)
Plant genetic engineering: transformation and transgenic plants, gene
transfer and genetic engineering technologies, molecular mechanism of
Agrobacterium mediated genetic transformation. Ti and Ri Plasmids,
Multiple Gene Transfer (MGT) to Plants and engineering metabolic
pathways, Plant-pathogen interaction and disease resistance plants.
VIGS- Virus Induced Gene Silencing in plants, Regulatory Issues (7L)
Exploring model plant Arabidopsis/or any crop plant genomes and
introduction to plant genomics and biotechnology (2L)
Phyto-remediation and its applications (2L)
Plantibodies and Molecular Farming, Production of
Evaluation /assessment
phytochemicals/neutraceuticals (2L)
Introduction to Quantitative Inheritance (2L)
Molecular markers and Marker Assisted Selection/molecular breeding
(3L). Seed testing (1L).
a. Mid Semester examination- 30 %
b. End-Sem examination - 30 %
c. Quiz -15%
d. Laboratory work - 15%
e. Projects/ Assignments/ presentation - 10 %
10
Suggested readings
(With full list of authors,
publisher, year, edn etc.)
1. Indra KV, and Trevor T. (2005) Plant Cell and Tissue Culture, Kluwer
Academic Publishers
2. Introduction to plant cell tissue culture. MK Rajdan
3. Rainer F, and Stefan S. (2004), Molecular Farming-plant
made pharmaceuticals and technical proteins, Wiley Verlag & Co.
4. Kan W, (2006) Agrobacterium protocols (Methods in Molecular
Biology), Vol. 1 and 2, Humana Press
5. In addition to the suggested books, papers are from Current Opinion
in Biotechnology. Trends in Plant Science, Plant Cell Report, Plant
Science and Plant Biotechnology etc.
Course code
BIO 301/401
2
3
Course Title
Credits
Collins Assisi*
5
6
7
each)
9
Evaluation /assessment
10
Suggested readings
See above
To be decided by the project supervisor 70%
Project presentation evaluated by a departmental committee
30%
As per suggestion of the project advisor