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Introduction
Acute sinusitis (AS) is an infection of the
paranasal sinuses with inflammation of the nose.
Association of viral upper respiratory-tract infection with common colds is the most common
cause of acute sinusitis known as acute rhinosinusitis1. Approximately, 6-13% of viral upper
respiratory tract infections in children are complicated by the development of acute bacterial sinusitis (ABS)2-4. The most pathogens involved in
AS are Streptococcus pneumoniae, Haemophilus
influenzae and Moraxella catarrhalis5.
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Results
In total, 100 patients were enrolled. Forthyeight (48%) of the patients were female and 52
(52%) were male. The mean age in intervention
and control group was 6.38 3.07 years and 7.28
2.54 years respectively.
Demographic and clinical characteristics of
patients in the two groups have demonstrated in
Table I. As shown in the table, clinical features
were almost similar at baseline of the study in the
both studied groups and the differences between
them are negligible.
Severity score of symptoms before treatment
was 22.46 2.61 in intervention group and 23.50
3.19 in control group and there was little difference between the two groups.
At the end of the treatment, symptom severity
score in intervention and control group was
11.68 2.66 and 14.84 2.92 respectively.
Discussion
Although, in theory, inhaled corticosteroids can
be effective to reduce symptoms of acute sinusitis
and inflammation of the mucus membranes, few
clinical trials have shown the beneficial effect of
topical intranasal steroids in children14,15.
The results of this study demonstrated the beneficial effect of co-administration of the amoxicillin with fluticasone nasal spray (FNS) one puff
twice daily for 14 days compared with control
Characteristics
Congestion score
Anterior discharge score
Posterior discharge
Fullness
Headache
Toothache
Cough
Malodorous
Exhaustion
Fever
Recovery
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Score
Intervention group
No. (%)
2
3
4
2
3
4
2
3
4
1
2
1
2
1
2
1
2
3
1
2
1
2
1
2
Complete
Relative
32 (64%)
16 (32%)
2 (4%)
38 (76%)
11 (22%)
1 (2%)
42 (84%)
8 (16%)
0 (0%)
44 (88%)
5 (10%)
46 (92%)
4 (8%)
46 (92%)
4 (8%)
32 (64%)
16 (32%)
2 (4%)
45 (90%)
5 (10%)
47 (92%)
3 (6%)
49 (98%)
1 (2%)
21 (42%)
29 (58%)
Control group
No. (%)
10 (20%)
32 (64%)
8 (16%)
3 (6%)
35 (70%)
2 (4%)
20 (40%)
28 (56%)
2 (4%)
29 (58%)
21 (42%)
30 (60%)
20 (40%)
44 (88%)
6 (12%)
16 (32%)
32 (64%)
2 (4%)
34 (68%)
16 (32%)
47 (92%)
3 (6%)
49 (98%)
1 (2%)
2 (4%)
48 (96%)
p value
< 0.001
< 0.001
< 0.001
0.001
< 0.001
0.370
0.005
0.006
0.661
0.753
< 0.001
Conclusions
This study showed that use of fluticasone
nasal spray can reduce the severity of symptoms
of sinusitis in children. It is suggested that this
treatment should be considered in children with
acute sinusitis.
Conflict of Interest
References
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