Beruflich Dokumente
Kultur Dokumente
6, 2013
Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine,
Stanford, CA 94305-5208, USA
2
Center for Global Pediatrics, University of Minnesota, Minneapolis, MN 55414-1932, USA
3
Department of Community Health and Primary Care, College of Medicine, University of Lagos, Lagos State, Nigeria
Summary
We evaluated nine semi-transparent plastic window-tinting films for their ability to block ultraviolet
A (UVA) and infrared (IR) radiation and transmit therapeutic blue light (400520 nm) for treating
jaundiced newborns. For indoor testing, three light sources (TL/52 special blue fluorescent, Black Light
UVA and IR heat lamps) were positioned above each film and measured successively using a thermocouple thermometer, UVA radiometer and blue light irradiance meter, placed below each film.
For outdoor testing, the same setup was used with the sun at zenith and a cloudless sky. Compared
with unfiltered radiation, blue light transmission through films ranged from 24 to 83%, UVA transmission was 0.17.1% and reductions in IR heat were 612 C and 510 C for heat lamp and sun,
respectively. The data suggest that most of the relatively low-cost window-tinting films tested can
effectively reduce sunlight UV and IR and offer a range of significant attenuations of therapeutic
blue light.
Key words: bilirubin, Jaundice, Hyperbilirubinemia, Newborn, Phototherapy
Introduction
Sunlight phototherapy (PT) has been investigated as
a treatment for hyperbilirubinemia because of its
ability to reduce jaundice and serum total bilirubin
levels in infants with hyperbilirubinemia [13].
However, direct sunlight is undesirable for treatment
because it has a number of significant clinical and
Acknowledgements
The authors received editorial support from John J.
Mahoney. They express their thanks for offers of expertise and donation of samples of window-tinting
films by Tom King of V-KOOl, Inc., Houston, TX
(V-KOOl 55 and 70), and Tammy OMeara of
Window Innovations, Inc., Brentwood, CA (Huper
Optik, Select Sech).
Funding
This work was supported by the Mary L. Johnson
Research Fund, the Christopher Hess Research Fund
and the H.M. Lui Research Fund.
The Author [2013]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com
doi:10.1093/tropej/fmt062
Advance Access published on 23 July 2013
496
H. J. VREMAN ET AL.
TABLE 1
Light (%T) and heat (IR) transmission ( C) for lamp- and sunlight through n 9 flexible window-tinting
films with attached liner
Light
source
Film (Type)
IRd C (Te)
t (min)f
Lamp
No Film
1. TAP R-20 (Mh)
2. Gila Titanium (M)
3. Gila Platinum (M)
4. V-KOOl 55 (Si)
5. Gila Light (M)
6. Huper Select (S)
7. TAP R-50 (M)
8. V-KOOl 70 (S)
9. Air Blue 80 (S)
21.5
7.1
9.3
10.1
12.3
12.5
12.9
14.0
15.4
17.9
(100)
(33)
(43)
(47)
(57)
(57)
(60)
(66)
(71)
(83)
2226
9
8
157
1
11
1
12
2
<1
(100)
(0.4)
(0.4)
(7.1)
(0.1)
(0.5)
(0.1)
(0.5)
(0.1)
(<0.1)
36
24.5
24.5
24
24
26
26.5
28
24
30
(0)
(11.5)
(11.5)
(12)
(12)
(10)
(9.5)
(8)
(12)
(6)
NDg
ND
ND
ND
ND
ND
ND
ND
ND
ND
Sunj
No Film
1. TAP R-20 (M)
2. Gila Titanium (M)
3. Gila Platinum (M)
4. V-KOOl 55 (S)
5. Gila Light (M)
6. Huper Select (S)
7. TAP R-50 (M)
8. V-KOOl 70 (S)
9. Air Blue 80 (S)
114
28
38
44
60
64
66
68
78
91
(100)
(24)
(33)
(38)
(53)
(56)
(53)
(60)
(68)
(79)
1526
8
7
75
4
8
4
13
4
2
(100)
(0.5)
(0.4)
(4.9)
(0.2)
(0.5)
(0.2)
(0.8)
(0.2)
(0.1)
36
26
26.5
27
28
29
29
31
29
30
(0)
(10)
(9.5)
(9)
(8)
(7)
(7)
(5)
(7)
(6)
4.0
10.0
10.2
7.4
8.0
10.2
7.7
8.0
7.2
4.7
Notes:
a
Blue Light Tl 20W/52 (Philips, Amsterdam, The Netherlands) measured by BiliBlanket Meter II.
b
%T is the percentage of light transmitted by a film relative to the light presented to that film (no film 100%).
c
UVA Black light, F15T8-BLB (General Electric, Hartford, CT) measured by Goldilux UVA photometer.
d
IR Heat Lamp, 115VAC, 250W powered at 80VAC (General Electric) measured by a thermocouple thermometer.
e
Ambient temperatures for lamp and sun experiments were 20 C and 18 C, respectively.
f
The t is the number of minutes required for the bilirubin concentration to decrease to half its original value.
g
ND not determined.
h
M metalized.
i
S spectrally selective transition metal oxynitride.
j
Sunlight @ zenith, cloudless sky.
Journal of Tropical Pediatrics
497
Films
Representative samples of nine metalized (M) and
metal oxynitride (S) films [TAP R-20 (M), Titanium
(M), Gila Platinum (M), V-KOOl 55 (S), Gila Light
(M), Huper Select (S), TAP R-50 (M), V-KOOl 70 (S)
and Air Blue 80 (S)] were obtained from the companies
listed in Table 1. Presently, Solutia, Inc. (St Louis,
MO) owns these brands. The retail price of the films
tested range from US $0.50 (for M-type film) to $2.00
(for S-type film) per 30 30 cm (or 1 sq. ft.).
H. J. VREMAN ET AL.
Light Source
(a)
(b)
Determinations of t
The method and calculations for the determination
of t (min) for bilirubin photodestruction to diazonegative compounds were performed as previously
described [8]. In summary, sets of (n 3) hematocrit
tubes containing 25 ml of a bilirubin/human serum
albumin (BR/HSA, 25 mg/dl/4% HSA in buffer)
solution were exposed at 37 C to filtered sunlight.
The remaining BR concentrations were quantitated
using a diazo-reaction assay. The rate of BR photodegradation (t1/2) was then determined through
interpolation of plotted % BR degraded vs. time
(min). We found that the t1/2s (efficacy) for a
number of artificial light PT devices ranged from 16
to 67 min (in Table 3, ref 8).
Data Analysis
Percent transmission (%T) for blue and UVA radiation was calculated for each film using the equation:
[%T (Film/No Film) 100%]. The transmission of
IR is expressed as the difference [ (delta) T] in temperature ( C) between unfiltered and filtered sunlight.
Results and Discussion
The results of testing the films with the three types of
radiation are shown in Table 1, with the data
arranged in order of increasing %T of therapeutic
blue light (range 3383%) relative to unfiltered
lamp light. The sunlight %T values for the films
were similar, but relatively lower (range: 2479%)
than for lamplight. This is likely due to the meters
response to the broader-spectrum and higherJournal of Tropical Pediatrics
Film Support
H. J. VREMAN ET AL.
H. J. VREMAN ET AL.
References
FIG. 2. Possible applications of sunlight filters.
(A) Photograph of a simple portable individual sunlight PT setup using a rugged wire canopy for support of a 60 90-cm sheet of Air Blue 80 (for use
with an overcast sky). (B) An example of a low-cost
portable canopy (240 240-cm footprint 180 cm in
height) for group or communal sunlight PT, constructed from polyvinyl chloride (PVC) irrigation
tubing. The canopy frame was covered with a panel
(240 360 cm) of Gila Titanium window-tinting film
for use with clear-sky sunlight PT. Note the shadow
cast by the film, which transmits 33% of the suns
therapeutic blue light.
basket, which is placed in sunlight, filtered with a
relatively small panel of film (60 90 cm)
draped over a simple (wire) frame (Fig. 2A);
2. Portable group or community treatment facility
(Fig. 2B). This type of configuration is presently
being studied in Nigeria, where the mothers,
seated in comfortable seats, can hold and bond
with their babies as well as nurse, while interacting with other mothers and infants [10];
3. Permanent hospital-based treatment facility. This
type of facility is economically more expensive
and involves the building of a more or less permanent PT facility with optimal orientation to
the daily and seasonal course of the sun [17] and
maximum and optimally placed overhead and
vertical windows covered with carefully selected
500
A significant limitation of sunlight PT is that sunlight radiation levels can and do change hourly, daily
and seasonally [3]. It is therefore likely that sunlight
PT will be most practical in medical facilities near
the equator, where sunlight is relatively plentiful
and intense, and where ambient air temperatures
are sufficiently high to keep the nearly naked
patients body temperature within safe levels. It
may also be a sustainable alternative PT option for
worldwide application.
Finally, filtered sunlight PT could be a particularly
powerful therapeutic tool when it is combined
with solar panel energy-capturing/storage systems
and efficient light-emitting diode-based PT devices
for treatment, when sufficient sunlight is not available [18].
H. J. VREMAN ET AL.
501