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12. Bile stasis in the liver due to extrahepatic bile obstruction. Canalicular
and intracytoplasmic accumulation of bile pigment. A few PMN
leukocytes.
18. Necrosis of the small bowel due to incarceration. Ischemic necrosis due to
strangulation (hemorrhagic type). Palely staining eosinophilic. There is no
nuclear staining in a wall of a necrotic artery.
19. Hepar moshatum adiposum Nutmeg liver. Liver congestion from right sided
heart failure, we can see a dilated sinus system (around central vein). Fatty
change (steatosis) due to ischemia and RBCs is accumulating. And also a
small biliary congestion.
21. Pulmonary Edema. Transudation of fluid into the alveoli due to elevated
hydrostatic pressure because of LVF. The lumen of alveoli is filled with
pale eosinophilic material (low protein content). Carbon containing
macrophages are present and hemosiderin containing macrophages
indicate chronic pulmonary congestion.
37. Signet ring carcinoma in the stomach (PAS). Diffuse infiltrative pattern, mucinous
carcinoma of intracellular type. Desmoplastic in stroma (growth of fibrous
connective tissue). We cannot see gastric glands because of thickened mucosa
and muscularis. Signet rings within mucosa (they have a large amount of mucin
which pushes the nucleus out towards the periphery).
42. Squamous cell carcinoma of the penis. Invasive cancer. Infiltration of chronic
inflammatory cells. Tumor cells are poorly differentiated and do not possess
tonofilaments. Focal necrosis.
43. Basal cell carcinoma of the face. Nodular. Dermal nesting by small dark cells.
Palisaded pattern and keratin cysts occasionally. Numerous mitoses in the edges
of the tumor cell clusters.
44. Compound nevus. Migration of nevus from the junctional nests into the dermis
and aggregation. Both nevus cells and melanin-laden macrophages (melanophor
cells) are seen. Melanin pigment granules.
45. Superficial spreading malignant melanoma. Flat lesion with intraepidermal spread
and microinvasion of the dermis by malignant melanocytes. Atypical melanocytes.
Melanin-laden macrophages. Pagetoid invasion (upward spreading) by single
melanoma cells in superficial epidermis.
47. Leiomyoma with bizarre foci. Myometrial smooth muscle. Focal regressive atypia
within a benign tumor (pseudosarcomatous area). Prominent nuclear enlargements.
The tumor is made up of fascicles of typical smooth muscle cells. The bizarre foci
have irregular hyperchromatic nuclei (re/de-generative atypia).
48. Schwannoma. Benign nerve sheath tumor. Nuclear palisading and biphasic structure
Antoni A/Antoni B. In Antoni A we can see Verocay bodies, hyper cellularity. In
Antoni B we can see hypo cellularity.
49. Neurofibroma. Monophasic tumor of Scwann cells and nerve sheath fibroblasts
producing collagen fibers. Intact epidermis. Few thickened nerves pass through the
tumor. We can see Schwann cells with special immuno-histochemistry reaction.
52. Chronic lymphocytic leukemia in the Bone Marrow. Separation of lymphoid infiltrate
from hematopoietic marrow cell population. Lymphoid cells are a monotonous
population. The Hematopoetic marrow is variable. We can see erythroid islands,
megakaryocytes, granulocyte precursors and hemosiderin containing macrophages.
54. Diffuse large B-cell lymphoma. Anaplastic cells, centrally located prominent
nucleoli (immunoblast). Diffuse growt pattern, large cells.