DISTROFIAS Y

DEGENERACIONES
CORNEALES

iii

PREFACIO

iv

AUTORES CONTRIBUYENTES

vi

CONTENIDO

vii

CAPTULO 1

10

Referencias
1. American Academy Ophthalmology. Ciruga refractiva. 2008-2009
2. Durn de la Colina, Juan A. Anatomo fisiologa de la cornea. Artculo publicado en oftalmo.com
disponible en lnea [http://www.oftalmo.com/publicaciones/lentes/cap1.htm]
3. Elander, Richard. Principle and practice of refractive surgery. WB Saunders Company. Philadelphia 1997.
4. Gil del Rio Emilio; Lentes de Contacto. 1era edicin. Jims. Barcelona 1980.
5. Grosvenor, Theodore. Optometra de atencin primaria. Barcelona, 2005
6. Kanski Jack. Clinical Ophthalmology: a systematic approach. 6th edition. Elsevier Butterworth. Edinburgh
2007.
7. Kaufman Paul; ADLER Fisiologa del Ojo: aplicacin clnica. 10 Edicin. Elsevier. Madrid 2004.

Lectura Sugerida

Krachmer, Jay; Atlas de la cornea. 2da edicin. CD rom.

Macsai Marian; Anterior Segment. 1era edicin. Mosby Elsevier. Philadelphia 2008.
Mannis Mark; Cornea. 2th edicin. Elsevier Mosby. Philadelphia 2005.
Moses Robert A; Hart William M. ADLER Fisiologia del ojo. Octava edicin. Editorial Mdica Panamericana.
Buenos Aires 1988.
Pavan-Langston Deborah. Manual of ocular diagnosis and therapy. 6ta Edicin. Wolters Klumer.
Philadelphia. 2008.
Reinhard Thomas; Cornea and external disease. Springer. New York 2008.
Riordan Eva; Oftalmologa General de: Vaughan y Asbury. 14 edicin. Editorial el Manual Moderno.
Mxico 2009.
Thoft RA, Friend J. The X, Y, Z Hypothesis of corneal epithelial maintenance. INVES OPHTALMOL VIS SCI
24:1442-1443, 1983.
Vaughan, Daniel. Oftalmologa General. Bogot. 1997

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17

18

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28

29

30

31

32

33

34

35

36

37

38

39

40

41

Referencias
1.
2.
3.
4.
5.
6.

Dohlman Ch. Corneal edema. In Albert DM, Jakobiec FA: Principles and Practice of Ophthalmology.
Clinical Practice. Saunder. Philadelphia 1994. 2. ed. I: 245-256.
Pazos MCB, Surez A, Santos L, Rodrguez-Ares T, Capeans C, Snchez-Salorio M. Biomicroscopia
Ultrasnica. Un nuevo mtodo para la exploracin del segmento anterior del ojo. Studium
Ohthalmologicum 1995; 14: 329-337.
Reinstein DZ, Silverman RH, Coleman DJ. Epithelial and corneal thickness measurements by highfrecuency ultrasound digital signal processing. Ophthalmology 1994;101: 140-146.
Pazos B, Snchez-Salorio M, Surez A, Rodrguez- Ares T, Santos L. Biomicroscopia ultrasnica en la
planificacin quirrgica de la queratoplastia. Arch Soc Esp Oftalmol 1997; 72: 841-848.
Pavlin CJ, Foster FS. Ultrasonics Biomicroscopy of the eye. New York. Springer-Verlag Publising 1995;
163-165.
Pazos MCB, Surez A, Rodrguez-Ares MT, Capeans C, Snchez Salorio M. Estudio de la queratopata
pseudofquica: Exploracin con Biomicroscopia Ultrasnica. Arch Soc Esp Oftalmol (en prensa).

42
7.
8.
9.

Vastine DW, Weinberg RS, Sugar J, Binder PS. Stripping of Descemets membrane associated with
intraocular lens implantation. Arch Ophthalmol 1983; 101: 142-145.
Morinelli EN, Najac RD, Speaker MG, Tello C, Liebmann JM, Ritch R. Repair of Descements membrane
detachment with the assistance of intraoperative ultrasound biomicroscopy. Am J Ophthalmol 1996;
121: 718-720.
Gonzlez F, Surez-Pearanda JM, Dez-Feijo E, Pazos B, Snchez-Salorio M. Histopathological and
ultrasound biomicroscopy findings in a case of irreversible mydriasis after keratoplasty in keratoconus.
Acta Ophthalmol Scan 1997; 75: 474-476.

CAPTULO 3

44

45

46

47

48

49

50

51

52

53

54

55

56

57
Referencias
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.

Academia Americana de Oftalmologa. Enfermedades externas y cornea. En: Sutphin J, ed. Ciencias
bsicas y clnicas del curso 2007-2008. San Francisco, CA: Academia Americana de Oftalmologa, 2007:
305-329.
Weiss J, H Mller, Lisch W, et al. La clasificacin de la IC3D distrofias corneales. Crnea. 2008; 27: S1-S42.
Ridgway A, Akhtar S, Munier F, et al. El anlisis ultraestructural y molecular de las distrofias corneales
capa de Bowman: un origen epitelial? Invertir Ophthalmol Vis Sci. 2000; 41:3248-92.
Kannabiran C, Klintworth G. Las mutaciones genticas TGFBI en distrofias corneales. La mutacin
humana. 2006; 27:615-625.
Kanski J. Oftalmologa Clnica: un enfoque sistmico, 6 edicin. Filadelfia, PA: Heinemann: Butterworth,
2007: 291-302.
Boutboul S, G Negro, Moore J, et al. Un subgrupo de pacientes con distrofia epitelial de la membrana
basal corneal tienen mutaciones en TGFBI/BIGH3. Mutacin Humano 2006; 6:553-57.
Sridhar M, C Rapuano, Cosar C, et al. Queratectoma fototeraputica frente de diamante para pulir las
rebabas de la membrana de Bowman en el tratamiento de erosiones corneales recurrentes asociados con
la distrofia membrana basal anterior. Oftalmologa. 2002; 109:674-9.
Martillo B, E Bjorck, Langerstedt K, et. al. Una nueva enfermedad corneal con episodios recurrentes de
la erosin y la herencia autosmica dominante. Acta Ophthalmol. 2008; 86:758-63.
Franceschetti A. Hereditre rezidivierende erosin der Hornhaut. Augenheilk. 1928; 66:309-16.
Valle O. hereditaria erosiones corneales recurrentes: un estudio de la familia con especial referencia a la
distrofia de Fuchs. Acta Ophthalmol. 1967; 45:829-36.
Gales HJ: Una historia familiar de erosiones corneales. Trans Ophthalmol Soc Nueva Zelanda. 1956, 8:7778.
Lisch W, K Steuhl, Lisch C, et al. Una distrofia microqustica nuevo, en forma de banda y verticiladas del
epitelio corneal. Am J Ophthalmol. 1992, 114:35-44.
Alvarez-Fischer M, J Alvarez de Toledo, Barraquer R. distrofia corneal Lisch. Crnea. 2005; 24:494-95.
Butros S, Lang G, Alvarez de Toledo J, et al. Los patrones de la opacidad de distrofia corneal Lisch. Klin
Monbl Augenheilkd. 2006 Oct; 223:837-40.
Feder I, Jay M, Yue B, et al. La distrofia corneal subepitelial mucinoso. Correlaciones clnicas y patolgicas.
Arch Ophthalmol. 1993; 111:1106-1114.
Meesmann A. ber eine Bisher nicht beschriebebe dominante vererbte distrofia epithelialis crnea. Ber
Zusammenkunft Dtsch Ophthalmol Ges. 1938; 52:154-58.
Bellas B, Yanoff M, Pitts E, et al. Distrofia epitelial Meesmann de la crnea. Am J Ophthalmol. 1977;
83:633-42.

58
18. Quemaduras R. Meesmann s distrofia corneal. Trans Am Soc Ophthalmol. 1968, 66:530-635.
19. F Stocker, Holt L. Una rara forma de distrofia hereditaria del epitelio de la crnea: un estudio gentico,
clnico y patolgico. Trans Am Soc Ophthalmol. 1954; 52133-44.
20. Jalbert I, Stapleton F. Gestin de la Distrofia Meesmann sintomtico. Optom Vis Sci. 2009. 07 de
septiembre.
21. Weber F, Babel J. gelatinoso de abandono como la distrofia. Una forma de amiloidosis corneal primaria.
Arch Ophthalmol 1980; 98:144-48.
22. Ide T, Nischida K, Maeda N, et al. Un espectro de manifestaciones clnicas de la forma de gota gelatinosa
distrofia corneal en Japn. Am J Ophthalmol. 2004; 137:1081-84.
23. Shimazaki J, Shimmura S, Tsubota K. madre del limbo trasplante de clulas para el tratamiento de
la amiloidosis supepithelial de la crnea (gelatinosa de abandono como la distrofia). Crnea. 2002;
21:177-80.
24. Escudos M. ber eine Weitere familire Hornhaut-dystrophie (Reis). Klin Manotsbl Augenkeilkd. 1949;
114:386-97.
25. Reis W. familire, fleckige Hornhautentartung. Disch Med Wocheschr. 1917; 43:575.
26. Kuchle M, W Verde, Vlcker H, et al. La reevaluacin de distrofias corneales de la membrana de Bowman y
el estroma anterior (Reis-Buckler y Theil-Behnke tipos:.. Una luz y un estudio de microscopio electrnico
de ocho crneas y una revisin de la literatura Cornea 1995; 14:333-54.
27. Theil H. Behnke H. Eine Bisher unbekannte subepitheliale hereditare Hornhautdystrophie. Klin
Monatsble Augenheilkd. 1967; 150:862-74.
28. Kobayashi A, Sugiyama K. En vivo los resultados de la microscopa lser confocal distrofias membrana de
Bowman (Thiel-Behnke y Reis-Topes de distrofias corneales). Oftalmologa. 2007, 114:69-75.
29. Orndahl M, P. Fagerholm tratamiento de distrofias corneales con queratectoma phototheraputic. J
Refract Surg. 1998; 14: 129-35.
30. Shwartz M, H. Tayler gestin quirrgica de la distrofia corneal de Reis-escudos. Crnea. 1985; 4:100-7.
31. Grayson M, H. Wilbrandt distrofia de la membrana limitante anterior de la crnea (tipo de Reis-Buckler).
Am J Opthalmol. 1966; 61:345-49.
32. H. Biber Ueber einige seltene Hornhautkrankungen: oberflchliche morir Queratitis gittrige (disertacin
inaugural). Zurich, 1890.
33. Klintworth, GK: la distrofia corneal reticular. Una variedad hereditaria de amiloidosis restringida a la
crnea. Am J Pathol. 1967; 50:371-99.
34. Archivo E, R Feder, OGrady R, et al. Tipo de red distrofia corneal IIIA. Correlaciones clnicas e
histopatolgicas. Optholmol arco. 1991; 109:354-58.
35. Vajpayee I, J Tyagi, Sharma N, et al. Queratoplastia lamelar profunda anterior mediante la tcnica de gran
burbuja, para el tratamiento del estroma opacidades de la crnea. Am J Ophthalmol. 2007; 143:954-57.

59
36. Meretoja J. paramyloidosis familiar sistmica con distrofia reticular de la crnea, la neuropata craneal
progresiva, cambios en la piel y diversos sntomas internos. Un sndrome hereditario que antes no
exista. Ann Clin Res. 1969; 1:314-24.
37. Kivela T, Tarkkanen A, B Frangione, et al. Ocular de amiloide en la amiloidosis familiar deposicin,
Finlandia: un anlisis de gelsolina nativo y variante en el sndrome de Meretoja. Invertir Ophthalmol Vis
Sci. 1994; 35:3759-69.
38. Kawamoto K, N Morishige, Yamada N, et al. Retraso en la cicatrizacin de heridas epiteliales de crnea
despus de la queratoplastia penetrante en personas con distrofia corneal reticular. Am J Ophthalmol.
2006; 142:173-74.
39. Das S, Langenbucher A, B. Seitz Excimer lser queratectoma fototerapia para la distrofia corneal granular
y reticular: un estudio comparativo. J Refract Surg. 2005; 21:727-31.
40. Kamal K, S Rayner, Chen M, et al. Clsico distrofia reticular corneal asociado a gammapata monoclonal
despus de la exclusin de una mutacin TGFI. Crnea. 2009; 28:97-98.
41. Groenouw A. Kntchenfrmige Hornhauttrbungen (nodili la crnea). Augenheilkd arco. 1890; 21:28189.
42. Mller H. distrofia corneal granular tipo Groenouw I. Aspectos clnicos y genticos. Acta Opthalmol.
1991; 69 (Supl 198), 10-40.
43. Holland E, Daya S, Stone E, et al. Avellino distrofia corneal. Las manifestaciones clnicas e historia
natural. Oftalmologa. 1992; 99:1564-68.
44. R junio, Tchah H, Kim T, et al. Avellino cornal distrofia despus de LASIK. Ophthalmol. 2004; 111:463-68.
45. Lee J, Sulting R, Lee D, et al. La exacerbacin de la distrofia corneal granular tipo II (distrofia corneal
Avellino), despus de LASEK. J Refract Surg. 2008; 24:39-45.
46. Klintworth, G, F. Vogel distrofia macular corneal: un mucopolisacrido cido heredado la enfermedad de
almacenamiento de los fibroblastos de la crnea. Am J Pathol. 1964; 45:565-86.
47. Jonasson F, Oshima E, Thonar E, et al. Macular corneal dystrophy in Iceland. A clinical, genealogic, and
immunohistochemical study of 28 patients. Ophthalmology. 1996; 103:111-17.
48. Gruenauer-Kloevekorn C, Braeutigam S, Heinritz W, et al. Macular corneal dystrophy: mutational spectrum
in German patients, novel mutations and therapeutic options. Graefes Arco Clin Exp Ophthalmol. 2008:
246:1441-7
49. Schnyder W. Mitteilung ber einen neuen Typus von familirer Hornhauterkrankung. Schweiz Med
Wschr. 1929; 10: 559-517.617.
50. Lisch W, Weidle G, Lisch C et al. Schnyders dystrophy. Progression and metabolism. Ophthalmic Pediatr
Genet. 1986; 7: 45-56.

60
51. Weiss J, Rodrigues M, Kruth H et al. Panstromal Schyders corneal dystrophy. Ultrastructure and
histochemical studies. Ophthalmology. 1992;99:1072-81.
52. Weiss J. Schnyders dystrophy of the cornea. A Swede-Finn connection. Cornea. 1992; 11:83-101.
53. Weiss J, Visual morbidity in thirty-four families with Schnyders corneal dystrophy. Trans Am Soc
Ophthamol Vis Sci. 2007; 105:1-33.
54. Witschel H, Fine B, Grtzner P, et al. Congenital hereditary stromal dystrophy of the cornea. Arch
Ophthalmol. 1978; 96: 1043-51.
55. Van Ginderdeuren R, De Vos R, Casteels I, et al. Report of a new family with dominant congenital
hereditary stromal dystrophy of the cornea. Cornea. 2002;21:118-20.
56. Bredrup C, Knappsckog P, Majewski J, et al. Congenital stromal dystrophy of the cornea caused by a
mutation in the decorin gene. Invest Ophthalmol Vis Sci. 2005; 46:420-26.
57. Purcell J, Krachmer J, Weingeist T. Fleck corneal dystrophy. Arch Ophthalmol. 1977; 95:440-44.
58. Kiskaddon B, Campbell R, Waller R. Fleck dystrophy of the cornea: case report. Ann Ophthalmol. 1980;
12:700-04.
59. Assi A, Ebenezer N, Ficker L. Corneal fleck dystrophy in an English family. Br J Ophthalmol. 1999; 83:14078.
60. Carpel EF, Sigelman R, Doughman D. Posterior amorphous corneal dystrophy. Am J Ophthalmol. 1977;
83:629-32.
61. Dunn S, Krachmer J, Ching S. New findings in posterior amorphous corneal dystrophy. Arch Ophth. 1984;
102:236-39.
62. Johnson AT, Folberg R, Vrabec M, et al. The pathology of posterior amorphous corneal dystrophy.
Ophthalmology. 1990; 97:104-09.
63. Franois C, Scott, I, Green W, et al. Une nouvelle dystophie hrdo-familiale de la corne. J. Genet Hum.
1956; 5:189-96.
64. Meyer J, Quantock A, Thonar E, et al. Characterization of a central corneal cloudiness sharing features of
posterior crocodile shagreen and central cloudy dystrophy of Franois. Cornea. 1996; 15:347-54.
65. Zaidi A, Mcleod S. Laser in situ keratomileusis in a patient with presumed central cloudy corneal
dystrophy of Franois. Am J Ophthalmol. 2005; 139:37677.
66. Curran R, Kenyon, K Green W. Pre-descemets membrane corneal dystrophy. Am J Ophthalmol. 1974;
77:7110-16.
67. Ferandez-Sasso D, Acosta J, Malbran E. Punctiform and polychromatic pre-Descemets dominant corneal
dystrophy. Br J Ophthalmol. 1979; 63:336-38.
68. Kempster R, Hirst L, de la Cruz Z, et al. Clinicopathologic study of the cornea in X-linked ichthyosis. Arch
Opthalmol. 1997; 115:409-15.

61
69. Fuchs E. Dystrophia epithelialis cornea. Albrecht von Graefes Arch Clin Exp Ophthalmol. 1910; 76:478508.
70. Krachmer J, Purcell J, Joung C, et al. Corneal endothelial dystrophy. A study of 64 families. Arch
Ophthalmol. 1978; 96: 2036-39.
71. Sundin O, Jun A, Broman K, et al. Linkage of late-onset Fuchs corneal dystrophy to a novel locus at
13ptel-13q12.13. Invest Ophthalmol Vis Sci. 2006; 47:140-45.
72. Sudin O, Broman K, Chang H, et al. A common locus for late-onset Fuchs corneal dystrophy maps to
18q21.2-q21.32. Invest Ophthalmol Vis Sci. 2006; 47:3912-20.
73. Riazuddin S, Eghrari A, Al-Saif A, et al. Linkage of mild late-onset phenotype of Fuchs corneal dystrophy
to a novel locus at 5q33.1-q35.2. Invest Ophthalmol Vis Sci. 2009; 50:5667-71.
74. Cibis G, Krachmer J, Phelps C, et al. The clinical spectrum of posterior polymorphous dystrophy. Arch
Ophthalmol. 1977; 95:1529-37.
75. McCarney A, Kirkness C. Comparison between posterior polymorphous dystrophy and congenital
hereditary endothelial dystrophy of the cornea. Eye. 1988; 2:63-70.
76. Aldave A, Yellore V, Pricipe A, et al. Candidate gene screening for posterior polymorphous dystrophy.
Cornea 2005; 24:151-55.

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107

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112

113

114

115

Bibliografa
Bower, K. Novel corneal phenotype in a patient with Alport syndrome. Cornea. 2009 Jun;28(5):599-606.
Edelstein, S. et al. Genotype of lattice corneal dystrophy (R124C mutation in TGFBI) in a patient presenting
with features of Avellino corneal dystrophy. Cornea. 2010 Jun;29(6):698-700
Forooghian F. Successful conservative management of hydrops with perforation in pellucid marginal
degeneration. Can J Ophthalmol. 2006 Feb;41(1):74-7.
Gear, H. Recurrence of Thiel-Behnke corneal dystrophy: an electron microscopic study. Br J Ophthalmol.
2005 Apr;89(4):518.
Kanski, J. Clinical Ophthalmology: a Systematic Approach. 5th Ed. Textbook. Butterworth Heinemann.
London. 2003.
Kim S. The survival of donor-derived cells in a successfully grafted corneal button 10 years after penetrating
keratoplasty for lattice dystrophy. Ophthalmologica. 2009;223(6):396-400. Epub 2009 Jul 16.
Klintworth, G. Corneal dystrophies. Orphanet Journal of Rare Diseases. 4:7. 2009.
Lisch et. al. Contact lens-induced regression of Lisch epithelial corneal dystrophy. Cornea. 2010
Mar;29(3):342-5.
Mori H. Three-dimensional optical coherence tomography-guided phototherapeutic keratectomy for
granular corneal dystrophy. Cornea. 2009 Sep;28(8):944-7.
Patel, A. Comparative evaluation of big-bubble deep anterior lamellar keratoplasty and penetrating
keratoplasty in a case of macular corneal dystrophy. Cornea. 2009 Jun;28(5):583-5.
Simon, J et. al. Pediatric Ophthalmology and Strabismus. BCSC Section 6. 2009-2010. American Academy
of Ophthalmology. San Francisco. 2009.

116
Smolin, G. The Cornea. 3rd Ed. Textbook. Little, Brown and Company. Boston. 1994.
Sutphin, J et. al. External Disease and Cornea. BCSC Section 8. 2009-2010. American Academy of
Ophthalmology. San Francisco. 2009.
Tavakoli M. Clinical applications of corneal confocal microscopy. Clin Ophthalmol. 2008 Jun;2(2):435-45.
Traboulsi E. Hope and major strides for genetic diseases of the eye. J Genet. 2009 Dec;88(4):395-7.
Verdler, D. Map-dot-fingerprint Dystrophy. eMedicine Ophthalmology. http://emedicine.medscape.com/
article/1193945-overview. 2009.
Weiss, J.; Spagnolo, B. Crystalline Dystrophy. eMedicine Ophthalmology. http://emedicine.medscape.com/
article/1196212-overview. 2008.
Weiss, J et. al. The ICD3D Classification of the Corneal Dystrophies. Cornea. Vol. 27, Suppl. 2. pg. S1-S42.
December 2008.

CAPTULO 5

118

119

120

121

122

123

124

125

126

127

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135

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204

205

206

207

208

209

210

211

212

213

214

215

216

217

218

Bibliografa
1.

Abad JC; Rubinfeld RS; Del Valle M; Belin MW; Kurstin JM. Vertical D: a novel topographic pattern in some
keratoconus suspects. Ophthalmology. 2007; 114:1020-1026.
2. Ali JL, Shabayek MH. Corneal higher order aberrations: a method to grade keratoconus. J Refract Surg
2006; 22:539-545.
3. Alzamora JB, Arce CG, Schor P, Campos MSQ. Quantitative area topography: a new concept applied to
study normal and pathologic corneas. World Ophthalmology Congress, So Paulo, Brasil. Fev 2006.
Poster.
4. Alzamora JB, Maidana EJ, Arce CG, Schor P, Campos MSQ. Spatial variation of normal corneal thickness
assessed by Orbscan II. World Ophthalmology Congress, So Paulo, Brasil. Fev 2006. Poster.
5. Ambrosio Jr R, Wilson SE. Early pellucid marginal corneal degeneration: case reports of two refractive
surgery candidates. Cornea 2003; 21: 114-117.
6. Ambrosio Jr R. LASIK, pre and post issues progression of corneal thickness values from the thinnest point
toward the limbus in normal and keratoconus eyes. ASCRS, Washington, EUA. Abril 2005.
7. Ambrosio R, Alonso RS, Luz A, Coca Velarde LG. Corneal-thickness spatial profile and corneal-volume
distribution: tomographic indices to detect keratoconus. J Cataract Refract Surg, 2006; 32:1851-1859.
8. Ambrosio Jr R. Corneal biomechanics, pachymetric progression profile, and corneal volume: Indices for
detecting ectasia and screening refractive candidates. ASCRS 2007. Online Poster. http://ascrs2007.
abstractsnet.com/acover.wcs?entryid=000242.
9. Arce CG, Sartori M, Campos M, Stillitano I, Ferraz C, Mallmann F. Topographic patterns in corneas with
keratoconus and intracorneal segments implanted. Poster. 2006; ESCRS Meeting, London, UK.
10. Arce CG, Francesconi CM. Caractersticas do Orbscan (Bausch & Lomb). Em: Vieira Netto M, Ambrosio R Jr,
Schor P, Chalita MR, Chamon W, eds. Wavefront, Topografia e Tomografia da Crnea e Segmento Anterior.
Rio de Janeiro, Brazil: Editora Cultura Mdica Ltda; 2006:123-139.
11. Arce CG, Martiz J, Alzamora JB, Schor P, Campos MSQ. Sectorial and annular quantitative area pachymetry
with the Orbscan II. J Refract Surgery 2007, 3:89-92
12. Arce CG, Campos M, Schor P. Overlooked features of corneal topographers. J Cataract Refract Surg 2008;
34:719-720

219
13. Arce CG. Optical pachymetry as diagnostic tool for KC and other pathologies. Poster 008. XXXV Brazilian
Congress of Ophthalmology. Belo Horizonte, MG. August 2009. Arq Bras Oftalmol. 2009; 72(Supl):33.
http://www.abonet.com.br/abo/724s/31-74.pdf.
14. Arce CG. User tips: Improve your results with the Galilei. Cataract Refract Surg Today Europe, 2009;
Supplement, April:11-15.
15. Arce CG, Polisuk P. Topografia de varredura com iluminao em fendas vertical ou rotatria e sistemas
hbridos. In: Polisuk P. ed. Rio de Janeiro, Cutura Mdica. 2010, pp 209-235.
16. Arce CG, Trattler W. Keratoconus and Keratoectasia. In Atlas of Corneal Pathology and Surgery. Boyd S. et
al, Editors. Jaypee Highlights Medical Publishers. Panam. 2010.
17. Arce CG. GALILEI Color scales and report formats. New features in software release 5.2. Galilei Technical
Bulletin No. 4. Ziemer Ophthalmic Systems AG. Port, Switzerland. Jan 2010
18. Arce CG. Galilei: topografa de Plcido y tomografa del segmento anterior con doble Scheimpflug.
Chapter 18th. Spanish Society of Cataract and Refractive Surgery (SECOIR) 2011 Memorial Book. Madrid.
May 2011.
19. Arntz A, Duran JA, Pijoan JI. Subclinical keratoconus diagnosis by elevation topography. Arch Soc Esp
Oftalmol. 2003; 78:659-664.
20. Auffarth GU, Wang L, Volcker HE. Keratoconus evaluation using the Orbscan topography system. J
Cataract Refract Surg 2000;26:222-228.
21. Baer E. Basic Properites and responses. In: MicNicol L, Strahlman E, eds. Corneal biophysics workshop.
Corneal biomechanics and wound healing. Bethesda, MD: NEI, 1989.
22. Belin MW, Khachikian SS. Corneal diagnosis and evaluation with the Oculus Pentacam. Highlights of
Ophthalmology. 2007; 35(2):5-8.
23. Belin MW, Khachikian SS, Ambrsio R, Salomo M. Keratoconus/ectasia detection with the Oculus
Pentacam: Belin/Ambrsio enhanced ectasia display. Highlights of Ophthalmology. 2007; 35(6):5-12.
24. Belin MW, Khachikian SS. An introduction to understanding elevation-based topography: how elevation
data are displayed a review. Clinical and Experimental Ophthalmology 2009; 37: 1429
25. Bessho K; Maeda N; Kuroda T; Fujikado T; Tano Y; Oshika T. Automated keratoconus detection using height
data of anterior and posterior corneal surfaces. Jpn J Ophthalmol. 2006; 50:409-416.
26. Bron AJ. Keratoconus. Cornea 1988; 7:163-169.
27. Bron AJ. The architecture of the corneal stroma. British J Ophthalmol 2001; 85:379-381.
28. Bhren J; Khne C; Kohnen T. Defining subclinical keratoconus using corneal first-surface higher-order
aberrations. Am J Ophthalmol. 2007; 143:381-38927.
29. Bhren J, Kook D, Yoon G, Kohnen T. Detection of subclinical keratoconus by using corneal anterior and
posterior surface aberrations and thickness spatial profiles. Invest Ophthalmol Vis Sci 2010; 51:34243432.

220
30. Cairns G, McGhee NJ. Orbscan computerized topography: Attributes, applications, and limitations. J
Cataract Refract Surg 2005; 31:205-220.
31. Caporossi A, Mazzotta C, Baiocchi S, Caporossi T. Long-term results of riboflavin ultraviolet a corneal
collagen cross-linking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol 2010.
149:585- 593.
32. Couto VR, Gontijo L, Kanadani FN, Gontijo ADC, Dorairaj SK. RIGITEST A new method to estimate
corneal hysteresis? A comparison between Normal subjects vs. Keratoconus patients. Poster. ARVO, Fort
Lauderdale. 2010
33. Dawson DG, Grossniklaus HE, McCarey BE, Edelhauser HF. Biomechanical and wound healing
characteristics of corneas after excimer laser keratorefractive surgery: is there a difference between
advanced surface ablation and sub-Bowmans keratomileusis? J Refract Surg 2008; 24:S90-S96.
34. Dawson DG, Randleman JB, Grossniklaus HE, OBrien TO, Dubovy SR, Schmack I, Stulting RD, Edelhauser
HF. Corneal ectasia after excimer laser keratorefractive surgery: histopathology, ultrastructure, and
pathophysiology. Ophthalmology 2008; 115:2181-2191
35. Dawson DG, Ubels JL, Edelahauser HF. Cornea and sclera. In: Kaufman PL, Alm A, eds. Adlers physiology
of the eye, 11th ed, 2010; In press.
36. Demirbas NH, Pflugfelder SC. Topographic pattern and apex location of keratoconus on elevation
topography maps. Cornea 1998; 17:476-484.
37. Dingeldein SA, Klyce SD, Wilson SE. Quantitative descriptors of corneal shape derived from computer
assisted analysis of photokeratoscopes. Refract Corneal Surg. 1989; 5:372-378.
38. Dupps WJ Jr, Wilson SE. Biomechanics and wound healing in the cornea. Exp Eye Res. 2006; 83:709-720.
39. Dupps WJ, Salomo MQ, Ambrosio R. Clinical biomechanics and the ocular response analyzer in ectatic
disease. In: Wang M, ed. Keratoconus & Keratoectasia: Prevention, diagnosis, and treatment. Thorofare,
NJ; Slack, 2010: 1328.
40. Elsheikh A. Understanding corneal biomechanics through experimental assessment and numerical
simulation. Eye and Vision Research Developments (series). Hauppauge, NY; Nova Science, 2010.
41. Fam HB, Lim KL. Corneal elevation indices in normal and keratoconic eyes. J Cataract Refract Surg. 2006,
32:1281-1287.
42. Fogla R, Rao SK, Padmanabhan P. Keratectasia in 2 case with pellucid marginal corneal degeneration
after laser in situ keratomileusis. J Cataract Refract Surg 2003; 29:788-791.
43. Francesconi CM, Arce CG. Representao dos mapas de elevao: Como interpretar o exame. Em: Vieira
Netto M, Ambrosio R Jr, Schor P, Chalita MR, Chamon W, eds. Wavefront, Topografia e Tomografia da
Crnea e Segmento Anterior. Rio de Janeiro, Brazil: Editora Cultura Mdica Ltda; 2006:183-193.
44. Fratzl P, ed. Collagen. Structure and mechanics. New York; Springer, 2008.

221
45. Fung YC. Biomechanics: Mechanical properties of living tissues (2nd ed.). New York; Springer-Verlag,
1993.
46. Gatinel D, Haouat M, Hoang-Xuan T. Etude des paramtres permettant la description mathmatique de
lasphricite cornenne. J Fr Ophthalmol. 2002; 25:81-90.
47. Gobbe M, Guillon M. Corneal wavefront aberration measurements to detect keratoconus patients. Cont
Lens Anterior Eye 2005; 28:57-66
48. Gontijo L. How to evaluate the efficiency of CXL. AAO-PAAO Meeting, San Francisco, 2009
49. Gritz DC, McDonnell PJ: Keratoconus and ocular massage. Am J Ophthalmol.1988; 106:757-758.
50. Ha NT. Nakayasu k, Murakami Y, Ishidoh K; Kanai A. Microassay analysis identified differentially expressed
gennes in keratocytes from keratoconus patients. Curr Eye Res 2004; 28:373-379.
51. Hafezi F, Mrochen M, Iseli HP, Seiler T. Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin
solution in thin corneas. J Cataract Refract Surg. 2009; 35:621-624.
52. Hayes S, Boote C, Lewis J, Sheppard J, Abahussin M, Quantock AJ, Purslow C, Votruba M, Meek KM.
Comparative study of fibrillar collagen arrangement in the corneas of primates and other mammals.
Anat Rec (Hoboken) 2007; 290:1542-1550.
53. Holland DR, Maeda N, Hannush SB, Riveroll LH, Green MT, Klyce SD, Wilson SE. Unilateral keratoconus.
Incidence and quantitative topographic analysis. Ophthalmology. 1997; 104:1409-1413
54. Jafri B; Li X; Yang H; Rabinowitz YS. Higher order wavefront aberrations and topography in early and
suspected keratoconus. J Refract Surg. 2007; 23:774-781
55. Jankov MR, Hafezi F, Beko M, Ignjatovic Z, Djurovic B, Markovic V, Schor P. Corneal cross-linking for the
treatment of keratoconus: preliminary results. Arq. Bras. Oftalmol. 2008. 71:813-818.
56. Ker R. Damage and failure. In: Fratzl P, ed. Collagen. Structure and mechanics. New York: Springer, 2008:
111-131.
57. Komai Y, Ushiki T. The three-dimensional organization of collagen fibrils in the human cornea and sclera.
Invest Ophthalmol Vis Sci 1991; 32:2244-2258.
58. Kotecha A, Elsheikh A, Roberts CR, Zhu H, Garway-Heath DF. Corneal thickness- and age-related
biomechanical properties of the cornea measured with the ocular response analyzer. Invest Ophthalmol
Vis Sci. 2006; 47:5337-5347.
59. Krachmer JH. Pellucid marginal corneal degeneration. Arch Ophthalmol . 1978; 96:1217-1921
60. Krachmer JH, Feder RS, Belin MW. Keratoconus and related noninflammatory corneal thinning disorders.
Surv Ophthalmol 1984; 28:293-322.
61. Krumeich JH, Daniel J. Live epikeratophakia and deep lamellar keratoplasty for I-III stage-specific surgical
treatment of keratoconus. Klin Monatsbl Augenheilkd 1997; 211:94-100.
62. Maeda N, Klyce SD, Smolek MK, Thompson HW. Automated keratoconus screening with corneal
topography analysis. Invest Ophthalmol Vis Sci 1994; 35:2749-2757.

222
63. Maeda N, Klyce SD, Smolek MK. Comparison of methods for detecting keratoconus using
videokeratography. Arch Ophthalmol 1995; 113:870-874.
64. Maguire LJ, Bourne WN. Corneal topography of early keratoconus. Am J Ophthalmol 1989; 108:107-112.
65. Maguire LJ, Lowry JCC. Identifying progression of subclinical keratoconus by serial topography analysis.
Am J Ophthalmol 1991; 112:41-45.
66. Mandell RB, Polse KA. Keratoconus: Spatial variation of corneal thickness as a diagnostic test. Arch
Ophthalmol 1969; 82:182-188.
67. Meek KM, Truft SJ, Huang Y, Gill PS, Hayes S, Newton RH, Bron AJ. Changes in collagen orientation and
distribution in keratoconus corneas. Invest Ophthalmol Vis Sci, 2005; 46:1948-1956.
68. Meek KM. The cornea and sclera. In: Frazl P, ed. Collagen: Structure and Mechanics. New York: Springer,
2008: 359-396.
69. Mihltz K; Krnitz K; Kovcs I; Takcs A; Nmeth J; Nagy ZZ. Shifting of the line of sight in keratoconus
measured by a Hartmann-Shack sensor. Ophthalmology; 2010. 117:41-48.
70. Myrowitz EH, Melia M, OBrien TP. The relationship between long-term contact lens wear and corneal
thickness. CLAO 2002, 28:217-220.
71. Nesburn AB, Bahri S, Salz J, Rabinowitz YS, Maguen E, Hofbauer J, Berlin M, Macy JI. Keratoconus detected
by videokeratography in candidates for photorefractive keratectomy. J Refract Surg 1995; 11:194- 201.
72. OBrart DPS, Saunders DC, Corbett MC, Rosen ES. The corneal topography of keratoconus. Eur J Implant
Refract Surg 1995; 7:20-30.
73. Oie Y; Maeda N; Kosaki R; Suzaki A; Hirohara Y; Mihashi T; Hori Y; Inoue T; Nishida K; Fujikado T; Tano
Y. Characteristics of ocular higher-order aberrations in patients with pellucid marginal corneal
degeneration. J Cataract Refract Surg; 2008. 34:1928-1934
74. Pantanelli S; MacRae S; Jeong TM; Yoon G. Characterizing the wave aberration in eyes with keratoconus
or penetrating keratoplasty using a high-dynamic range wavefront sensor. Ophthalmology; 2007.
114:2013-2021
75. Pesudovs K; Coster DJ. Penetrating keratoplasty for keratoconus: the nexus between corneal wavefront
aberrations and visual performance. J Refract Surg; 2006. 22:926-931.
76. Pflugfelder SC, Liu Z, Feuer W, Verm A. Corneal thickness indices discriminate between keratoconus and
contact lens-induced corneal thinning. Ophthalmology 2002. 109:2336-2341
77. Piero DP, Ali JL, Alesn A, Vergara ME, Miranda M. Corneal volume, pachymetry, and correlation of
anterior and posterior corneal shape in subclinical and different stages of clinical keratoconus. J Cataract
Refract Surg 2010; 36:814-825
78. Rabinowitz YS, McDonnel PJ. Computer-assisted corneal topography in keratoconus. Refract Corneal
Surg 1989; 5:400-408

223
79. Rabinowitz YS, Garbus J, McDonnel PJ. Computer-assisted corneal topography in family members of
patients with keratoconus. Arch Ophthalmol 1990; 108:365-371
80. Rabinowitz YS. Videokeratographic ndices to aid in screening for keratoconus. J Refract Surg 1995;
11:371-379.
81. Rabinowitz YS, Rasheed K, Yang H, Elashoff J. Accuracy of ultrasonic pachymetry and videokeratography
in detecting keratoconus. J Cataract Refract Surg. 1998; 24:196-201.
82. Rabinowitz YS. Keratoconus. Surv Ophthalmol 1998; 42:297-319.
83. Rabinowitz YS, Rasheed K. KISA% index: a quantitative videokeratography algorithm embodying
minimal topographic criteria for diagnosing keratoconus. J Cataract Refract Surg 1999; 25:1327-1335.
84. Rabinowitz YS. The genetics of keratoconus. Ophthalmol Clin North Am 2003; 16:607-620.
85. Rao SN, Raviv T, Majmudar PA, Epstein RA. Role of Orbscan II in screening keratoconus suspects before
refractive corneal surgery. Ophthalmology 2002; 109:1642-1646.
86. Redmond KB. The role of heredity in keratoconus. Trans Ophthalmol Soc NZ 1968; 27:52-54
87. Saad A, Lteif Y, Azan E, Gatinel D. Biomechanical properties of keratoconus suspect eyes. Invest
Ophthalmol Vis Sci. 2010; 51:2912-2916.
88. Schlegel Z, Hoang-Xuan T, Gatinel D. Comparison of and correlation between anterior and posterior
corneal elevation maps in normal eyes and keratoconus-suspect eyes. J Cataract Refract Surg. 2008;
34:789-795.
89. Schlegel Z, Lteif Y, Bains HS, Gatinel D. Total, corneal, and internal ocular optical aberrations in patients
with keratoconus. J Refract Surg. 2009; 25:S951-S957.
90. Silver FH, Kato YP, Ohno M, Wasserman AJ. Analysis of mammalian connective tissue: Relationship
between hierarchical structures and mechanical properties. J Long Term Eff Med Implants 1992; 2:165198.
91. Silver FH, Landis WJ. Viscoelasticity, energy storage and transmission and dissipation by extracellular
matrices in vertebraes. In: Fratzl P, ed. Collagen. Structure and mechanics. New York: Springer, 2008:
133-154.
92. Smolek MK, Klyce SD, Maeda N. Keratoconus and contact lens-induced corneal warpage analysis using
the keratomorphic diagram. Invest Ophthal Vis Sci. 1994; 35:4192-4204
93. Smolek MK, Klyce SD. Is keratoconus a true ectasia? An evaluation of corneal surface area. Arch
Ophthalmol. 2000; 118:1179-1186.226 Distrofias y Degeneraciones Corneales.
94. Smolek MK, Klyce SD, Hovis JK. The Universal Standard Scale: Proposed improvements to the American
National Standards Institute (ANSI) scale for corneal topography. Ophthalmology 2002. 109:361-369
95. Smolek MK, Klyce SD. Absolute color scale for improved diagnostics with wavefront error mapping.
Ophthalmology 2007. 114:2022-2030

224
96. Snook RK. Pachymetry and true topography using the Orbscan system. Em: Gills JP, Sanders DR, Thornton
SP, Martin RG, Gayton JL, Holladay JT, Van Der Karr M, eds. Corneal Topography. The State of the Art.
Thorofare, NJ: SLACK Inc; 1995:89-103
97. Stillitano I, Alzamora JB,. Arce CG, Schor P, Campos MSQ. Quantitative area pachymetry of corneas with
keratoconus. World Ophthalmology Congress, So Paulo, Brazil. Fev 2006. Poster.
98. Tanabe T, Oshika T, Tomidokoro A, Amano S, Tanaka S, Kuroda T, Maeda N, Tokunaga T, Miyata K.
Standardized color-coded scales for anterior and posterior elevation maps of scanning slit corneal
topography. Ophthalmology 2002;109:1298-1302
99. Tang M, Shekhar R, Miranda D, Huang D. Characteristics of keratoconus and pellucid marginal
degeneration in mean curvature maps. Ophthalmology. 2005; 140:993-1001.
100. Tang M, Shekhar R, Huang D. Mean curvature mapping for the detection of corneal shape abnormality.
IEEE Trans Med Imaging 2005; 24:424-428.
101. Timidokoro A, Oshika T, Amano S, Higaki S, Maeda N, Miyata K. Changes in anterior and posterior corneal
curvature in keratoconus. Ophthalmology 2000; 107:1328-1332.
102. Vinciguerra PP, Ab E, Trazza S, Rosetta P, Vinciguerra R, Seiler T, Epstein D. Refractive, Topographic,
Tomographic, and Aberrometric Analysis of Keratoconic Eyes Undergoing Corneal Cross-Linking.
Ophthalmology 2009. 116:369-378
103. Vogel, S. Comparative Biomechanics: Lifes Physical World. Princeton, NJ: Princeton University Press,
2003: 299-331
104. Wang M. Keratoconus and Keratoectasia: Prevention, Diagnosis and Treatment. Slack Inc. 2010
105. Wilson SE, Lin DT, Klyce SD, Reidy JJ, Insler MS. Topographic changes in contact lens-induced corneal
warpage Ophthalmology 1990; 97:734-744
106. Wilson SE, Lin DTC, Klyce SD. Corneal topography of keratoconus. Cornea 1991; 10:2-8.
107. Wilson SE, Klyce SD. Quantitative descriptors of corneal topography. Arch Ophthalmol. 1991; 109:349353
108. Wilson SE, Klyce SD. Screening for corneal topographic abnormalities before refractive surgery
Ophthalmology 1994; 101:147-152
109. Zadnik K, Steger- May K, Fink BA, Joslin CE, Nichols JJ, Rosenstiel CE, Tyler JA, Yu JA, Raasch TW,
Schechtman KB, CLEK Study Group. Between-eye asymmetry in keratoconus. Cornea 2002; 21:671-679.

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