Beruflich Dokumente
Kultur Dokumente
DOI: 10.1021/om100106e
Tables of 1H and 13C NMR chemical shifts have been compiled for common organic compounds
often used as reagents or found as products or contaminants in deuterated organic solvents. Building
upon the work of Gottlieb, Kotlyar, and Nudelman in the Journal of Organic Chemistry, signals for
common impurities are now reported in additional NMR solvents (tetrahydrofuran-d8, toluene-d8,
dichloromethane-d2, chlorobenzene-d5, and 2,2,2-trifluoroethanol-d3) which are frequently used in
organometallic laboratories. Chemical shifts for other organics which are often used as reagents or
internal standards or are found as products in organometallic chemistry are also reported for all the
listed solvents.
ethylene, propylene, and carbon dioxide) often encountered as reagents or products in organometallic reactions,
along with organic compounds relevant to organometallic
chemists (allyl acetate, benzaldehyde, carbon disulfide,
carbon tetrachloride, 18-crown-6, cyclohexanone, diallyl
carbonate, dimethyl carbonate, dimethyl malonate, furan,
Apiezon H grease, hexamethylbenzene, hexamethyldisiloxane, imidazole, pyrrole, and pyrrolidine), have also
been added to this expanded list.
Experimental Section
All deuterated solvents were obtained commercially through
Cambridge Isotope Laboratories, Inc. NMR spectra were
recorded at 298 K using 300, 500, or 600 MHz spectrometers
(13C{1H} NMR frequencies of 75.5, 126, or 151 MHz, respectively). Adopting the previously reported strategy,2 standard
solutions of mixtures of specific impurities were used to reduce
the number of necessary individual NMR experiments. The
combinations of organic compounds were chosen in a way in
which intermolecular interactions and resonance convolution
would be minimized. Unless otherwise stated, the standard
solutions were prepared with qualitatively equal molar amounts
of the following compounds: (solution 1) acetone, dimethylformamide, ethanol, toluene; (solution 2) benzene, dimethyl sulfoxide, ethyl acetate, methanol; (solution 3) acetic acid, chloroform, diethyl ether, 2-propanol, tetrahydrofuran; (solution 4)
acetonitrile, dichloromethane, 1,4-dioxane, n-hexane, hexamethylphosphoramide (HMPA); (solution 5) 1,2-dichloroethane,
n-pentane, pyridine, hexamethylbenzene; (solution 6) tert-butyl
alcohol, 2,6-di-tert-butyl-4-methylphenol (BHT), cyclohexane,
pubs.acs.org/Organometallics
Fulmer et al.
Table 1. 1H NMR Dataa
proton
solvent residual
signals
mult
THF-d8
CD2Cl2
CDCl3
toluene-d8
C6D6
1.72
3.58
5.32
7.26
2.08
6.97
7.01
7.09
7.16
2.05
2.50
1.94
TFE-d3
5.02
3.88
CD3OD D2O
3.31
4.79
OH
s
2.46
1.52
1.56
0.43
0.40
1.03
2.84b
3.33b
2.13
3.66
4.87
CH3
s
1.89
2.06
2.10
1.57
1.52
1.76
1.96
1.91
1.96
2.06
1.99
2.08
s
2.05
2.12
2.17
1.57
1.55
1.77
2.09
2.09
2.08
2.19
2.15
2.22
CH3
s
1.95
1.97
2.10
0.69
0.58
1.21
2.05
2.07
1.96
1.95
2.03
2.06
CH3
CH
s
7.31
7.35
7.36
7.12
7.15
7.20
7.36
7.37
7.37
7.36
7.33
s
1.15
1.24
1.28
1.03
1.05
1.12
1.18
1.11
1.16
1.28
1.40
1.24
CH3
OH
sc
3.16
0.58
0.63
1.30
4.19
2.18
2.20
chloroform
CH
s
7.89
7.32
7.26
6.10
6.15
6.74
8.02
8.32
7.58
7.33
7.90
18-crown-6
CH2
s
3.57
3.59
3.67
3.36
3.39
3.41
3.59
3.51
3.51
3.64
3.64
3.80
s
1.44
1.44
1.43
1.40
1.40
1.37
1.43
1.40
1.44
1.47
1.45
cyclohexane
CH2
1,2-dichloroethane
CH2
s
3.77
3.76
3.73
2.91
2.90
3.26
3.87
3.90
3.81
3.71
3.78
s
5.51
5.33
5.30
4.32
4.27
4.77
5.63
5.76
5.44
5.24
5.49
dichloromethane
CH2
diethyl ether
CH3
t, 7
1.12
1.15
1.21
1.10
1.11
1.10
1.11
1.09
1.12
1.20
1.18
1.17
CH2
q, 7
3.38
3.43
3.48
3.25
3.26
3.31
3.41
3.38
3.42
3.58
3.49
3.56
m
3.43
3.57
3.65
3.43
3.46
3.49
3.56
3.51
3.53
3.67
3.61
3.67
diglyme
CH2
CH2
m
3.53
3.50
3.57
3.31
3.34
3.37
3.47
3.38
3.45
3.62
3.58
3.61
s
3.28
3.33
3.39
3.12
3.11
3.16
3.28
3.24
3.29
3.41
3.35
3.37
OCH3
dimethylformamide
CH
s
7.91
7.96
8.02
7.57
7.63
7.73
7.96
7.95
7.92
7.86
7.97
7.92
CH3
s
2.88
2.91
2.96
2.37
2.36
2.51
2.94
2.89
2.89
2.98
2.99
3.01
CH3
s
2.76
2.82
2.88
1.96
1.86
2.30
2.78
2.73
2.77
2.88
2.86
2.85
s
3.56
3.65
3.71
3.33
3.35
3.45
3.59
3.57
3.60
3.76
3.66
3.75
1,4-dioxane
CH2
DME
CH3
s
3.28
3.34
3.40
3.12
3.12
3.17
3.28
3.24
3.28
3.40
3.35
3.37
CH2
s
3.43
3.49
3.55
3.31
3.33
3.37
3.46
3.43
3.45
3.61
3.52
3.60
s
0.85
0.85
0.87
0.81
0.80
0.79
0.83
0.82
0.85
0.85
0.85
0.82
ethane
CH3
ethanol
CH3
t, 7
1.10
1.19
1.25
0.97
0.96
1.06
1.12
1.06
1.12
1.22
1.19
1.17
d
q, 7
3.51
3.66
3.72
3.36
3.34
3.51
3.57
3.44
3.54
3.71
3.60
3.65
CH2
c,d
OH
s
3.30
1.33
1.32
0.83
0.50
1.39
3.39
4.63
2.47
s
1.94
2.00
2.05
1.69
1.65
1.78
1.97
1.99
1.97
2.03
2.01
2.07
ethyl acetate
CH3CO
CH2CH3
q, 7
4.04
4.08
4.12
3.87
3.89
3.96
4.05
4.03
4.06
4.14
4.09
4.14
CH2CH3
t, 7
1.19
1.23
1.26
0.94
0.92
1.04
1.20
1.17
1.20
1.26
1.24
1.24
s
5.36
5.40
5.40
5.25
5.25
5.29
5.38
5.41
5.41
5.40
5.39
5.44
ethylene
CH2
e
ethylene glycol
CH2
s
3.48
3.66
3.76
3.36
3.41
3.58
3.28
3.34
3.51
3.72
3.59
3.65
CH3
m
0.85-0.91 0.84-0.90 0.84-0.87 0.89-0.96 0.90-0.98 0.86-0.92
0.90
0.82-0.88
0.88-0.94 0.86-0.93
H greasef
CH2
br s
1.29
1.27
1.25
1.33
1.32
1.30
1.29
1.24
1.33
1.29
s
2.18
2.20
2.24
2.10
2.13
2.10
2.17
2.14
2.19
2.24
2.19
hexamethylbenzene
CH3
n-hexane
CH3
t, 7
0.89
0.89
0.88
0.88
0.89
0.85
0.88
0.86
0.89
0.91
0.90
CH2
m
1.29
1.27
1.26
1.22
1.24
1.19
1.28
1.25
1.28
1.31
1.29
s
0.07
0.07
0.07
0.10
0.12
0.10
0.07
0.06
0.07
0.08
0.07
0.28
HMDSO
CH3
HMPA
CH3
d,9.5
2.58
2.60
2.65
2.42
2.40
2.47
2.59
2.53
2.57
2.63
2.64
2.61
s
4.55
4.59
4.62
4.50
4.47
4.49
4.54
4.61
4.57
4.53
4.56
hydrogen
H2
imidazole
CH(2)
s
7.48
7.63
7.67
7.30
7.33
7.53
7.62
7.63
7.57
7.61
7.67
7.78
CH(4,5)
s
6.94
7.07
7.10
6.86
6.90
7.01
7.04
7.01
7.01
7.03
7.05
7.14
methane
CH4
s
0.19
0.21
0.22
0.17
0.16
0.15
0.17
0.20
0.20
0.18
0.20
0.18
sg
3.27
3.42
3.49
3.03
3.07
3.25
3.31
3.16
3.28
3.44
3.34
3.34
methanol
CH3
c,g
OH
s
3.02
1.09
1.09
1.30
3.12
4.01
2.16
nitromethane
CH3
s
4.31
4.31
4.33
3.01
2.94
3.59
4.43
4.42
4.31
4.28
4.34
4.40
t, 7
0.89
0.89
0.88
0.87
0.87
0.84
0.88
0.86
0.89
0.90
0.90
n-pentane
CH3
CH2
m
1.31
1.30
1.27
1.25
1.23
1.23
1.27
1.27
1.29
1.33
1.29
t, 7.3
0.90
0.90
0.90
0.89
0.86
0.84
0.88
0.87
0.90
0.90
0.91
0.88
propane
CH3
CH2
sept, 7.3
1.33
1.32
1.32
1.32
1.26
1.26
1.31
1.29
1.33
1.33
1.34
1.30
d, 6
1.08
1.17
1.22
0.95
0.95
1.04
1.10
1.04
1.09
1.20
1.50
1.17
2-propanol
CH3
CH
sept, 6
3.82
3.97
4.04
3.65
3.67
3.82
3.90
3.78
3.87
4.05
3.92
4.02
propylene
CH3
dt, 6.4, 1.5
1.69
1.71
1.73
1.55
1.55
1.58
1.68
1.68
1.70
1.70
1.70
1.70
dm, 10
4.89
4.93
4.94
4.92
4.95
4.91
4.90
4.94
4.93
4.93
4.91
4.95
CH2(1)
CH2(2)
dm, 17
4.99
5.03
5.03
4.98
5.01
4.98
5.00
5.03
5.04
5.03
5.01
5.06
CH
m
5.79
5.84
5.83
5.70
5.72
5.72
5.81
5.80
5.85
5.87
5.82
5.90
pyridine
CH(2,6)
m
8.54
8.59
8.62
8.47
8.53
8.51
8.58
8.58
8.57
8.45
8.53
8.52
CH(3,5)
m
7.25
7.28
7.29
6.67
6.66
6.90
7.35
7.39
7.33
7.40
7.44
7.45
CH(4)
m
7.65
7.68
7.68
6.99
6.98
7.25
7.76
7.79
7.73
7.82
7.85
7.87
pyrrole
NH
br t
9.96
8.69
8.40
7.71
7.80
8.61
10.02
10.75
9.27
CH(2,5)
m
6.66
6.79
6.83
6.43
6.48
6.62
6.77
6.73
6.75
6.84
6.72
6.93
CH(3,4)
m
6.02
6.19
6.26
6.27
6.37
6.27
6.07
6.01
6.10
6.24
6.08
6.26
h
pyrrolidine
CH2(2,5)
m
2.75
2.82
2.87
2.54
2.54
2.64
2.67
2.75
3.11
2.80
3.07
CH2(3,4)
m
1.59
1.67
1.68
1.36
1.33
1.43
1.55
1.61
1.93
1.72
1.87
s
0.11
0.09
0.07
0.26
0.29
0.14
0.13
-0.06
0.08
0.16
0.10
silicone grease
CH3
tetrahydrofuran
CH2(2,5)
m
3.62
3.69
3.76
3.54
3.57
3.59
3.63
3.60
3.64
3.78
3.71
3.74
m
1.79
1.82
1.85
1.43
1.40
1.55
1.79
1.76
1.80
1.91
1.87
1.88
CH2(3,4)
toluene
CH3
s
2.31
2.34
2.36
2.11
2.11
2.16
2.32
2.30
2.33
2.33
2.32
CH(2,4,6)
m
7.10
7.15
7.17
6.96-7.01
7.02
7.01-7.08 7.10-7.20
7.18
7.10-7.30 7.10-7.30
7.16
CH(3,5)
m
7.19
7.24
7.25
7.09
7.13
7.10-7.17 7.10-7.20
7.25
7.10-7.30 7.10-7.30
7.16
triethylamine
CH3
t, 7
0.97
0.99
1.03
0.95
0.96
0.93
0.96
0.93
0.96
1.31
1.05
0.99
q,7
2.46
2.48
2.53
2.39
2.40
2.39
2.45
2.43
2.45
3.12
2.58
2.57
CH2
water
acetic acid
acetone
acetonitrile
benzene
tert -butyl alcohol
a
Except for the compounds in solutions 8-10, as well as the gas samples, hexamethylbenzene, and the corrected values mentioned in the Supporting
Information, all data for the solvents CDCl3, C6D6, (CD3)2CO, (CD3)2SO, CD3CN, CD3OD, and D2O were previously reported in ref 2. b A signal for
HDO is also observed in (CD3)2SO (3.30 ppm) and (CD3)2CO (2.81 ppm), often seen as a 1:1:1 triplet (2JH,D = 1 Hz). c Not all OH signals were
observable. d In some solvents, the coupling interaction between the CH2 and the OH protons may be observed (J = 5 Hz). e In CD3CN, the OH proton
was seen as a multiplet at 2.69 ppm, as well as extra coupling to the CH2 resonance. f Apiezon brand H grease. g In some solvents, a coupling interaction
between the CH3 and the OH protons may be observed (J = 5.5 Hz). h Pyrrolidine was observed to react with (CD3)2CO.
Article
acetic acid
acetone
acetonitrile
benzene
tert -butyl alcohol
carbon dioxide
carbon disulfide
carbon tetrachloride
chloroform
18-crown-6
cyclohexane
1,2-dichloroethane
dichloromethane
diethyl ether
diglyme
dimethylformamide
1,4-dioxane
DME
ethane
ethanol
ethyl acetate
ethylene
ethylene glycol
H greaseb
hexamethylbenzene
n-hexane
HMDSO
HMPAc
imidazole
methane
methanol
nitromethane
n-pentane
propane
2-propanol
propylene
pyridine
pyrrole
pyrrolidinee
silicone grease
tetrahydrofuran
toluene
triethylamine
CO
CH3
CO
CH3
CN
CH3
CH
(CH3)3C
(CH3)3C
CO2
CS2
CCl4
CH
CH2
CH2
CH2
CH2
CH3
CH2
CH3
CH2
CH2
CH
CH3
CH3
CH2
CH3
CH2
CH3
CH3
CH2
CH3CO
CO
CH2
CH3
CH2
CH2
CH2
C
CH3
CH3
CH2(2,5)
CH2(3,4)
CH3
CH3
CH(2)
CH(4,5)
CH4
CH3
CH3
CH3
CH2(2,4)
CH2(3)
CH3
CH2
CH3
CH
CH3
CH2
CH
CH(2,6)
CH(3,5)
CH(4)
CH(2,5)
CH(3,4)
CH2(2,5)
CH2(3,4)
CH3
CH2(2,5)
CH2(3,4)
CH3
C(1)
CH(2,6)
CH(3,5)
CH(4)
CH3
CH2
THF-d8
CD2Cl2
CDCl3
toluene- d8
C6D6
C6D5Cl
(CD3)2CO
(CD3)2SO
CD3CN
TFE-d3
CD3OD
67.21
25.31
53.84
77.16
137.48
128.87
127.96
125.13
20.43
128.06
134.19
129.26
128.25
125.96
29.84
206.26
39.52
1.32
118.26
61.50
126.28
49.00
171.69
20.13
204.19
30.17
116.79
0.45
128.84
67.50
30.57
125.69
193.37
96.89
79.24
71.34
27.58
44.64
54.67
15.49
66.14
58.72
71.17
72.72
161.96
35.65
30.70
67.65
58.72
72.58
6.79
18.90
57.60
20.45
170.32
60.30
14.37
123.09
64.35
30.45
131.88
16.71
14.22
23.33
32.34
1.83
36.89
135.72
122.20
-4.90
49.64
62.49
14.18
23.00
34.87
16.60
16.82
25.70
66.14
19.27
115.74
134.02
150.57
124.08
135.99
118.03
107.74
45.82
26.17
1.20
68.03
26.19
21.29
138.24
129.47
128.71
125.84
12.51
47.18
175.85
20.91
206.78
31.00
116.92
2.03
128.68
69.11
31.46
125.26
192.95
96.52
77.99
70.47
27.38
44.35
54.24
15.44
66.11
58.95
70.70
72.25
162.57
36.56
31.39
67.47
59.02
72.24
6.91
18.69
58.57
21.15
171.24
60.63
14.37
123.20
64.08
30.14
132.09
16.93
14.28
23.07
32.01
1.96
36.99
135.76
122.16
-4.33
50.45
63.03
14.24
22.77
34.57
16.63
16.63
25.43
64.67
19.47
115.70
134.21
150.27
124.06
136.16
117.93
108.02
47.02
25.83
1.22
68.16
25.98
21.53
138.36
129.35
128.54
125.62
12.12
46.75
175.99
20.81
207.07
30.92
116.43
1.89
128.37
69.15
31.25
124.99
192.83
96.34
77.36
70.55
26.94
43.50
53.52
15.20
65.91
59.01
70.51
71.90
162.62
36.50
31.45
67.14
59.08
71.84
6.89
18.41
58.28
21.04
171.36
60.49
14.19
123.13
63.79
29.71
132.21
16.98
14.14
22.70
31.64
1.97
36.87
135.38
122.00
-4.63
50.41
62.50
14.08
22.38
34.16
16.63
16.37
25.14
64.50
19.50
115.74
133.91
149.90
123.75
135.96
117.77
107.98
46.93
25.56
1.19
67.97
25.62
21.46
137.89
129.07
128.26
125.33
11.61
46.25
175.30
20.27
204.00
30.03
115.76
0.03
128.57
68.12
30.49
124.86
192.71
96.57
77.89
70.86
27.31
43.40
53.47
15.47
65.94
58.62
70.92
72.39
161.93
35.22
30.64
67.17
58.63
72.25
6.94
18.78
57.81
20.46
170.02
60.08
14.23
122.92
64.29
30.31
131.72
16.84
14.34
23.12
32.06
1.99
36.80
135.57
122.13
-4.34
49.90
61.14
14.27
22.79
34.54
16.65
16.63
25.24
64.12
19.32
115.89
133.61
150.25
123.46
135.17
117.61
108.15
47.12
25.75
1.37
67.75
25.79
21.37
137.84
129.33
128.51
125.66
12.39
46.82
175.82
20.37
204.43
30.14
116.02
0.20
128.62
68.19
30.47
124.76
192.69
96.44
77.79
70.59
27.23
43.59
53.46
15.46
65.94
58.66
70.87
72.35
162.13
35.25
30.72
67.16
58.68
72.21
6.96
18.72
57.86
20.56
170.44
60.21
14.19
122.96
64.34
30.22
131.79
16.95
14.32
23.04
31.96
2.05
36.88
135.76
122.16
-4.29
49.97
61.16
14.25
22.72
34.45
16.66
16.60
25.18
64.23
19.38
115.92
133.69
150.27
123.58
135.28
117.78
108.21
46.86
25.65
1.38
67.80
25.72
21.10
137.91
129.33
128.56
125.68
12.35
46.77
175.67
20.40
204.83
30.12
115.93
0.63
128.38
68.19
31.13
126.08
192.49
96.38
77.67
70.55
26.99
43.60
53.54
15.35
65.79
58.42
70.56
72.07
162.01
35.45
30.71
66.95
58.31
71.81
6.91
18.55
57.63
20.50
170.20
60.06
14.07
122.95
64.03
30.11
131.54
16.68
14.18
22.86
31.77
1.92
36.64
135.50
121.96
-4.33
49.66
61.68
14.10
22.54
34.26
16.56
16.48
25.14
64.18
19.32
115.86
133.57
149.93
123.49
135.32
117.65
108.03
46.75
25.59
1.09
67.64
25.68
21.23
137.65
129.12
128.31
125.43
11.87
46.36
172.31
20.51
205.87
30.60
117.60
1.12
129.15
68.13
30.72
125.81
193.58
96.65
79.19
71.25
27.51
45.25
54.95
15.78
66.12
58.77
71.03
72.63
162.79
36.15
31.03
67.60
58.45
72.47
6.88
18.89
57.72
20.83
170.96
60.56
14.50
123.47
64.26
171.93
20.95
206.31
30.56
117.91
1.03
128.30
66.88
30.38
124.21
192.63
95.44
79.16
69.85
26.33
45.02
54.84
15.12
62.05
57.98
69.54
71.25
162.29
35.73
30.73
66.36
58.03
71.17
6.61
18.51
56.07
20.68
170.31
59.74
14.40
123.52
62.76
173.21
20.73
207.43
30.91
118.26
1.79
129.32
68.74
30.68
125.89
193.60
96.68
79.17
71.22
27.63
45.54
55.32
15.63
66.32
58.90
70.99
72.63
163.31
36.57
31.32
67.72
58.89
72.47
6.99
18.80
57.96
21.16
171.68
60.98
14.54
123.69
64.22
177.96
20.91
32.35
214.98
118.95
1.00
129.84
72.35
31.07
126.92
196.26
97.74
78.83
70.80
28.34
45.28
54.46
15.33
67.55
59.40
73.05
71.33
166.01
37.76
30.96
68.52
59.52
72.87
7.01
18.11
59.68
21.18
175.55
62.70
14.36
124.08
64.87
175.11
20.56
209.67
30.67
118.06
0.85
129.34
69.40
30.91
126.31
193.82
97.21
79.44
71.47
27.96
45.11
54.78
15.46
66.88
59.06
71.33
72.92
164.73
36.89
31.61
68.11
59.06
72.72
6.98
18.40
58.26
20.88
172.89
61.50
14.49
123.46
64.30
132.22
16.86
14.34
23.28
32.30
2.01
37.04
135.89
122.31
-5.33
49.77
63.21
14.29
22.98
34.83
16.68
16.78
25.67
63.85
19.42
116.03
134.34
150.67
124.57
136.56
117.98
108.04
131.10
16.60
13.88
22.05
30.95
1.96
36.42
135.15
121.55
-4.01
48.59
63.28
13.28
21.70
33.48
16.34
15.67
25.43
64.92
19.20
116.07
133.55
149.58
123.84
136.05
117.32
107.07
46.51
25.26
132.61
16.94
14.43
23.40
32.36
2.07
37.10
136.33
122.78
-4.61
49.90
63.66
14.37
23.08
34.89
16.73
16.91
25.55
64.30
19.48
116.12
134.78
150.76
127.76
136.89
118.47
108.31
47.57
26.34
67.03
25.14
20.99
137.35
128.88
128.18
125.29
11.74
45.74
68.33
26.27
21.50
138.90
129.94
129.23
126.28
12.38
47.10
134.04
17.04
14.63
24.06
33.17
2.09
37.21
136.58
122.93
-5.88
50.67
63.17
14.54
23.75
35.76
16.93
17.46
25.21
66.69
19.63
116.38
136.00
149.76
126.27
139.62
119.61
108.85
47.43
25.73
2.87
69.53
26.69
21.62
139.92
130.58
129.79
126.82
9.51
48.45
132.53
16.90
14.45
23.68
32.73
1.99
37.00
136.31
122.60
-4.90
49.86
63.08
14.39
23.38
35.30
16.80
17.19
25.27
64.71
19.50
116.04
134.61
150.07
125.53
138.35
118.28
108.11
47.23
26.29
2.10
68.83
26.48
21.50
138.85
129.91
129.20
126.29
11.09
46.96
1.40
68.07
26.15
21.46
138.48
129.76
129.03
126.12
12.49
47.07
D2O
177.21
21.03
215.94
30.89
119.68
1.47
70.36
30.29
197.25
96.73
70.14
14.77
66.42
58.67
70.05
71.63
165.53
37.54
32.03
67.19
58.67
71.49
17.47
58.05
21.15
175.26
62.32
13.92
63.17
2.31
36.46
136.65
122.43
49.50d
63.22
24.38
64.88
149.18
125.12
138.27
119.06
107.83
46.83
25.86
68.68
25.67
9.07
47.19
a
Except for the compounds in solutions 8-10, as well as the gas samples, hexamethylbenzene, and the corrected values mentioned in the Supporting
Information, all data for the solvents CDCl3, C6D6, (CD3)2CO, (CD3)2SO, CD3CN, CD3OD, and D2O were previously reported in ref 2. b Apiezon
brand H grease. c Phosphorus coupling was observed (2JPC = 3 Hz). d Internal reference; see text. e Pyrrolidine was observed to react with (CD3)2CO.
Fulmer et al.
selected heteronuclear single-quantum coherence (gs-HSQC)
and gradient-selected heteronuclear multiple-quantum coherence
(gs-HMQC) NMR spectroscopies. For the experiments involving
gases, a J. Young NMR tube containing approximately 0.4 mL of
NMR solvent was first degassed with three freeze-pump-thaw
cycles. Using a vacuum line equipped with a gas manifold, 1 atm
of the desired gas was added to the tube. Each gas was run
separately, degassing between each gas sample.
Acknowledgment. G.R.F. and K.I.G. thank the Department of Energy (Contract No. DE-FG02-06ER15765) for
support. A.J.M.M. and J.E.B. thank the Moore Foundation for support. N.H.S. and B.M.S. thank Abbott Laboratories, Amgen, Merck, Bristol-Myers Squibb, Boehringer
Ingelheim, the Gordon and Betty Moore Foundation, and
Caltech for financial support.
Supporting Information Available: Large-format tables of the
all the NMR data. This material is available free of charge via
the Internet at http://pubs.acs.org.
(10) The misreported value for acetonitrile in C6D6 from the original
paper2 was also pointed out by Dr. Jongwook Choi, to whom we are
grateful.
7512
Results
Proton Spectra (Table 1). A sample of 0.6 mL of the
solvent, containing 1 L of TMS,1 was first run on its
own. From this spectrum we determined the chemical
shifts of the solvent residual peak2 and the water peak.
It should be noted that the latter is quite temperature(1) For recommendations on the publication of NMR data, see:
IUPAC Commission on Molecular Structure and Spectroscopy. Pure
Appl. Chem. 1972, 29, 627; 1976, 45, 217.
dependent (vide infra). Also, any potential hydrogenbond acceptor will tend to shift the water signal downfield; this is particularly true for nonpolar solvents. In
contrast, in e.g. DMSO the water is already strongly
hydrogen-bonded to the solvent, and solutes have only a
negligible effect on its chemical shift. This is also true
for D2O; the chemical shift of the residual HDO is very
temperature-dependent (vide infra) but, maybe counterintuitively, remarkably solute (and pH) independent.
We then added 3 L of one of our stock solutions to
the NMR tube. The chemical shifts were read and are
presented in Table 1. Except where indicated, the
coupling constants, and therefore the peak shapes, are
essentially solvent-independent and are presented only
once.
For D2O as a solvent, the accepted reference peak (
) 0) is the methyl signal of the sodium salt of 3-(trimethylsilyl)propanesulfonic acid; one crystal of this was added
to each NMR tube. This material has several disadvantages, however: it is not volatile, so it cannot be readily
eliminated if the sample has to be recovered. In addition,
unless one purchases it in the relatively expensive
deuterated form, it adds three more signals to the
spectrum (methylenes 1, 2, and 3 appear at 2.91, 1.76,
and 0.63 ppm, respectively). We suggest that the residual HDO peak be used as a secondary reference; we
find that if the effects of temperature are taken into
account (vide infra), this is very reproducible. For D2O,
we used a different set of stock solutions, since many of
the less polar substrates are not significantly watersoluble (see Table 1). We also ran sodium acetate and
sodium formate (chemical shifts: 1.90 and 8.44 ppm,
respectively).
Carbon Spectra (Table 2). To each tube, 50 L of
the stock solution and 3 L of TMS1 were added. The
solvent chemical shifts3 were obtained from the spectra
containing the solutes, and the ranges of chemical shifts
(2) I.e., the signal of the proton for the isotopomer with one less
deuterium than the perdeuterated material, e.g., CHCl3 in CDCl3 or
C6D5H in C6D6. Except for CHCl3, the splitting due to JHD is typically
observed (to a good approximation, it is 1/6.5 of the value of the
corresponding JHH). For CHD2 groups (deuterated acetone, DMSO,
acetonitrile), this signal is a 1:2:3:2:1 quintet with a splitting of ca. 2
Hz.
(3) In contrast to what was said in note 2, in the 13C spectra the
solvent signal is due to the perdeuterated isotopomer, and the onebond couplings to deuterium are always observable (ca. 20-30 Hz).
Notes
chloroform
cyclohexane
1,2-dichloroethane
dichloromethane
diethyl ether
diglyme
1,2-dimethoxyethane
dimethylacetamide
dimethylformamide
dimethyl sulfoxide
dioxane
ethanol
ethyl acetate
ethyl methyl ketone
ethylene glycol
grease f
n-hexane
HMPAg
methanol
nitromethane
n-pentane
2-propanol
pyridine
silicone greasei
tetrahydrofuran
toluene
triethylamine
CH3
CH3
CH3
CH
CH3
OHc
CCH3
OCH3
ArH
OHc
ArCH3
ArC(CH3)3
CH
CH2
CH2
CH2
CH3
CH2
CH2
CH2
OCH3
CH3
CH2
CH3CO
NCH3
NCH3
CH
CH3
CH3
CH3
CH2
CH3
CH2
OH
CH3CO
CH2CH3
CH2CH3
CH3CO
CH2CH3
CH2CH3
CH
CH3
CH2
CH3
CH2
CH3
CH3
OH
CH3
CH3
CH2
CH3
CH
CH(2)
CH(3)
CH(4)
CH3
CH2
CH2O
CH3
CH(o/p)
CH(m)
CH3
CH2
mult
s
s
s
s
s
s
s
s
s
s
s
s
s
s
s
s
s
t, 7
q, 7
m
m
s
s
s
s
s
s
s
s
s
s
s
t, 7
q, 7d
sc,d
s
q, 7
t, 7
s
q, 7
t, 7
se
m
br s
t
m
d, 9.5
sh
sc,h
s
t, 7
m
d, 6
sep, 6
m
m
m
s
m
m
s
m
m
t,7
q, 7
CDCl3
1H
NMR Data
(CD3)2CO
7.26
1.56
2.10
2.17
2.10
7.36
1.28
2.05
2.84a
1.96
2.09
2.05
7.36
1.18
1.19
3.22
6.98
5.01
2.27
1.43
7.26
1.43
3.73
5.30
1.21
3.48
3.65
3.57
3.39
3.40
3.55
2.09
3.02
2.94
8.02
2.96
2.88
2.62
3.71
1.25
3.72
1.32
2.05
4.12
1.26
2.14
2.46
1.06
3.76
0.86
1.26
0.88
1.26
2.65
3.49
1.09
4.33
0.88
1.27
1.22
4.04
8.62
7.29
7.68
0.07
1.85
3.76
2.36
7.17
7.25
1.03
2.53
1.13
3.13
6.96
2.22
1.41
8.02
1.43
3.87
5.63
1.11
3.41
3.56
3.47
3.28
3.28
3.46
1.97
3.00
2.83
7.96
2.94
2.78
2.52
3.59
1.12
3.57
3.39
1.97
4.05
1.20
2.07
2.45
0.96
3.28
0.87
1.29
0.88
1.28
2.59
3.31
3.12
4.43
0.88
1.27
1.10
3.90
8.58
7.35
7.76
0.13
1.79
3.63
2.32
7.1-7.2
7.1-7.2
0.96
2.45
(CD3)2SO
C6D6
CD3CN
CD3OD
D2O
2.50
3.33a
1.91
2.09
2.07
7.37
1.11
4.19
1.11
3.08
6.87
6.65
2.18
1.36
8.32
1.40
3.90
5.76
1.09
3.38
3.51
3.38
3.24
3.24
3.43
1.96
2.94
2.78
7.95
2.89
2.73
2.54
3.57
1.06
3.44
4.63
1.99
4.03
1.17
2.07
2.43
0.91
3.34
7.16
0.40
1.55
1.55
1.55
7.15
1.05
1.55
1.07
3.04
7.05
4.79
2.24
1.38
6.15
1.40
2.90
4.27
1.11
3.26
3.46
3.34
3.11
3.12
3.33
1.60
2.57
2.05
7.63
2.36
1.86
1.68
3.35
0.96
3.34
1.94
2.13
1.96
2.08
1.96
7.37
1.16
2.18
1.14
3.13
6.97
5.20
2.22
1.39
7.58
1.44
3.81
5.44
1.12
3.42
3.53
3.45
3.29
3.28
3.45
1.97
2.96
2.83
7.92
2.89
2.77
2.50
3.60
1.12
3.54
2.47
1.97
4.06
1.20
2.06
2.43
0.96
3.51
0.86
1.27
0.89
1.28
2.57
3.28
2.16
4.31
0.89
1.29
1.09
3.87
8.57
7.33
7.73
0.08
1.80
3.64
2.33
7.1-7.3
7.1-7.3
0.96
2.45
3.31
4.87
1.99
2.15
2.03
7.33
1.40
4.79
0.86
1.25
2.53
3.16
4.01
4.42
0.86
1.27
1.04
3.78
8.58
7.39
7.79
1.76
3.60
2.30
7.18
7.25
0.93
2.43
1.65
3.89
0.92
1.58
1.81
0.85
3.41
0.92
1.36
0.89
1.24
2.40
3.07
2.94
0.87
1.23
0.95
3.67
8.53
6.66
6.98
0.29
1.40
3.57
2.11
7.02
7.13
0.96
2.40
1.15
3.20
6.92
2.21
1.40
7.90
1.45
3.78
5.49
1.18
3.49
3.61
3.58
3.35
3.35
3.52
2.07
3.31
2.92
7.97
2.99
2.86
2.65
3.66
1.19
3.60
2.08
2.22
2.06
1.24
1.21
3.22
1.17
3.56
3.67
3.61
3.37
3.37
3.60
2.08
3.06
2.90
7.92
3.01
2.85
2.71
3.75
1.17
3.65
2.01
4.09
1.24
2.12
2.50
1.01
3.59
0.88
1.29
0.90
1.29
2.64
3.34
2.07
4.14
1.24
2.19
3.18
1.26
3.65
4.34
0.90
1.29
1.50
3.92
8.53
7.44
7.85
0.10
1.87
3.71
2.32
7.16
7.16
1.05
2.58
4.40
2.61
3.34
1.17
4.02
8.52
7.45
7.87
1.88
3.74
0.99
2.57
a In these solvents the intermolecular rate of exchange is slow enough that a peak due to HDO is usually also observed; it appears at
2.81 and 3.30 ppm in acetone and DMSO, respectively. In the former solvent, it is often seen as a 1:1:1 triplet, with 2JH,D ) 1 Hz.
b 2,6-Dimethyl-4-tert-butylphenol. c The signals from exchangeable protons were not always identified. d In some cases (see note a), the
coupling interaction between the CH2 and the OH protons may be observed (J ) 5 Hz). e In CD3CN, the OH proton was seen as a multiplet
at 2.69, and extra coupling was also apparent on the methylene peak. f Long-chain, linear aliphatic hydrocarbons. Their solubility in
DMSO was too low to give visible peaks. g Hexamethylphosphoramide. h In some cases (see notes a, d), the coupling interaction between
the CH3 and the OH protons may be observed (J ) 5.5 Hz). i Poly(dimethylsiloxane). Its solubility in DMSO was too low to give visible
peaks.
Notes
Table 2.
solvent signals
acetic acid
CO
CH3
acetone
CO
CH3
acetonitrile
CN
CH3
benzene
CH
tert-butyl alcohol
C
CH3
tert-butyl methyl ether OCH3
C
CCH3
BHT
C(1)
C(2)
CH(3)
C(4)
CH3Ar
CH3C
C
chloroform
CH
cyclohexane
CH2
1,2-dichloroethane
CH2
dichloromethane
CH2
diethyl ether
CH3
CH2
diglyme
CH3
CH2
CH2
1,2-dimethoxyethane
CH3
CH2
dimethylacetamide
CH3
CO
NCH3
NCH3
dimethylformamide
CH
CH3
CH3
dimethyl sulfoxide
CH3
dioxane
CH2
ethanol
CH3
CH2
ethyl acetate
CH3CO
CO
CH2
CH3
ethyl methyl ketone
CH3CO
CO
CH2CH3
CH2CH3
ethylene glycol
CH2
grease
CH2
n-hexane
CH3
CH2(2)
CH2(3)
HMPAb
CH3
methanol
CH3
nitromethane
CH3
n-pentane
CH3
CH2(2)
CH2(3)
2-propanol
CH3
CH
pyridine
CH(2)
CH(3)
CH(4)
silicone grease
CH3
tetrahydrofuran
CH2
CH2O
toluene
CH3
C(i)
CH(o)
CH(m)
CH(p)
triethylamine
CH3
CH2
a
CDCl3
(CD3)2CO
77.16 ( 0.06
29.84 ( 0.01
206.26 ( 0.13
172.31
20.51
205.87
30.60
117.60
1.12
129.15
68.13
30.72
49.35
72.81
27.24
152.51
138.19
129.05
126.03
21.31
31.61
35.00
79.19
27.51
45.25
54.95
15.78
66.12
58.77
71.03
72.63
58.45
72.47
21.51
170.61
34.89
37.92
162.79
36.15
31.03
41.23
67.60
18.89
57.72
20.83
170.96
60.56
14.50
29.30
208.30
36.75
8.03
64.26
30.73
14.34
23.28
32.30
37.04
49.77
63.21
14.29
22.98
34.83
25.67
63.85
150.67
124.57
136.56
1.40
26.15
68.07
21.46
138.48
129.76
129.03
126.12
12.49
47.07
175.99
20.81
207.07
30.92
116.43
1.89
128.37
69.15
31.25
49.45
72.87
26.99
151.55
135.87
125.55
128.27
21.20
30.33
34.25
77.36
26.94
43.50
53.52
15.20
65.91
59.01
70.51
71.90
59.08
71.84
21.53
171.07
35.28
38.13
162.62
36.50
31.45
40.76
67.14
18.41
58.28
21.04
171.36
60.49
14.19
29.49
209.56
36.89
7.86
63.79
29.76
14.14
22.70
31.64
36.87
50.41
62.50
14.08
22.38
34.16
25.14
64.50
149.90
123.75
135.96
1.04
25.62
67.97
21.46
137.89
129.07
128.26
125.33
11.61
46.25
b 2J
PC
13C
NMR Dataa
(CD3)2SO
C6D6
175.82
20.37
204.43
30.14
116.02
0.20
128.62
68.19
30.47
49.19
72.40
27.09
152.05
136.08
128.52
125.83
21.40
31.34
34.35
77.79
27.23
43.59
53.46
15.46
65.94
58.66
70.87
72.35
58.68
72.21
21.16
169.95
34.67
37.03
162.13
35.25
30.72
40.03
67.16
18.72
57.86
20.56
170.44
60.21
14.19
28.56
206.55
36.36
7.91
64.34
30.21
14.32
23.04
31.96
36.88
49.97
61.16
14.25
22.72
34.45
25.18
64.23
150.27
123.58
135.28
1.38
25.72
67.80
21.10
137.91
129.33
128.56
125.68
12.35
46.77
CD3CN
CD3OD
1.32 ( 0.02
118.26 ( 0.02
173.21
20.73
207.43
30.91
118.26
1.79
129.32
68.74
30.68
49.52
73.17
27.28
152.42
138.13
129.61
126.38
21.23
31.50
35.05
79.17
27.63
45.54
55.32
15.63
66.32
58.90
70.99
72.63
58.89
72.47
21.76
171.31
35.17
38.26
163.31
36.57
31.32
41.31
67.72
18.80
57.96
21.16
171.68
60.98
14.54
29.60
209.88
37.09
8.14
64.22
30.86
14.43
23.40
32.36
37.10
49.90
63.66
14.37
23.08
34.89
25.55
64.30
150.76
127.76
136.89
49.00(0.01
26.27
68.33
21.50
138.90
129.94
129.23
126.28
12.38
47.10
175.11
20.56
209.67
30.67
118.06
0.85
129.34
69.40
30.91
49.66
74.32
27.22
152.85
139.09
129.49
126.11
21.38
31.15
35.36
79.44
27.96
45.11
54.78
15.46
66.88
59.06
71.33
72.92
59.06
72.72
21.32
173.32
35.50
38.43
164.73
36.89
31.61
40.45
68.11
18.40
58.26
20.88
172.89
61.50
14.49
29.39
212.16
37.34
8.09
64.30
31.29
14.45
23.68
32.73
37.00
49.86
63.08
14.39
23.38
35.30
25.27
64.71
150.07
125.53
138.35
2.10
26.48
68.83
21.50
138.85
129.91
129.20
126.29
11.09
46.96
D2O
177.21
21.03
215.94
30.89
119.68
1.47
70.36
30.29
49.37
75.62
26.60
14.77
66.42
58.67
70.05
71.63
58.67
71.49
21.09
174.57
35.03
38.76
165.53
37.54
32.03
39.39
67.19
17.47
58.05
21.15
175.26
62.32
13.92
29.49
218.43
37.27
7.87
63.17
36.46
49.50c
63.22
24.38
64.88
149.18
125.12
138.27
25.67
68.68
9.07
47.19
Notes
(1)
) 5.051 - 0.0111T
(2)
Supporting Information
Arnold and Mabel Beckman Laboratories of Chemical Synthesis, and Caltech Center for Catalysis and
Chemical Synthesis, Division of Chemistry and Chemical Engineering California Institute of Technology,
Pasadena, California 91125;
3
13
Individual Solvent Tables NMR Data Sorted by Chemical Shift (Tables S3S26) ............ S7
References .................................................................................................................................. S19
S1
S2
mult
THF-d 8
1.72
3.58
CD2Cl2
5.32
CDCl3
7.26
s
s
s
s
ddt
ddt
ddt
ddd
s
s
m
m
m
s
s
s5
s
s5
s
s
s
s5
s
s
s
s
s
t
m
m
ddt
ddt
ddt
ddd
s
s
t, 7
q, 7
m
m
s
s
s
s
s
s
s
s
s
s
s
s
s
s
s
t, 7
q, 76
s5,6
s
q, 7
t, 7
s
q, 7
t, 7
s
s7
dd
dd
m
br s
s
s
2.46
1.89
2.05
1.95
5.90
5.27
5.15
4.50
1.98
9.98
7.867.88
7.517.55
7.607.64
7.31
1.15
3.16
6.68
5.64
3.68
1.40
6.92
5.81
2.21
1.40
7.89
3.57
1.44
2.24
1.771.82
1.681.71
5.92
5.31
5.19
4.58
3.77
5.51
1.12
3.38
3.43
3.53
3.28
3.28
3.43
1.94
2.95
2.82
3.69
3.65
3.35
7.91
2.88
2.76
2.45
3.56
0.85
1.10
3.51
3.30
1.94
4.04
1.19
2.03
2.39
0.96
5.36
3.48
7.48
6.37
0.850.91
1.29
2.18
0.07
1.52
2.06
2.12
1.97
5.92
5.31
5.22
4.55
2.05
10.01
7.877.89
7.537.57
7.637.67
7.35
1.24
6.73
4.76
3.73
1.42
6.97
5.00
2.25
1.42
7.32
3.59
1.44
2.29
1.811.87
1.691.72
5.95
5.35
5.26
4.61
3.76
5.33
1.15
3.43
3.57
3.50
3.33
3.34
3.49
2.02
2.97
2.87
3.75
3.72
3.37
7.96
2.91
2.82
2.55
3.65
0.85
1.19
3.66
1.33
2.00
4.08
1.23
2.09
2.43
1.00
5.40
3.66
7.46
6.41
0.840.90
1.27
2.20
0.07
1.56
2.10
2.17
2.10
5.93
5.32
5.24
4.57
2.09
10.03
7.887.91
7.517.57
7.617.65
7.36
1.28
6.76
4.76
3.77
1.44
6.98
5.01
2.27
1.43
7.26
3.67
1.43
2.33
1.841.86
1.711.73
5.94
5.37
5.27
4.64
3.73
5.30
1.21
3.48
3.65
3.57
3.39
3.40
3.55
2.09
3.02
2.94
3.79
3.75
3.40
8.02
2.96
2.88
2.62
3.71
0.87
1.25
3.72
1.32
2.05
4.12
1.26
2.14
2.46
1.06
5.40
3.76
7.45
6.40
0.840.87
1.25
2.24
0.07
water
acetic acid
acetone
acetonitrile
allyl acetate
OH
CH3
CH3
CH3
CH CH2
CHCH 2(1)
CHCH 2(2)
CH2
CH3
benzaldehyde
HCO
CH(2,6)
CH(3,5)
CH(4)
benzene
CH
CH3
tert -butyl alcohol
OH
BHA
ArH
OH
ArOCH3
ArC(CH3)3
BHT
ArH
OH
ArCH3
ArC(CH3)3
chloroform
CH
CH2
18-crown-6
CH2
cyclohexane
CH2(2,6)
cyclohexanone
CH2(3,5)
CH2(4)
CH CH2
diallyl carbonate
CHCH 2(1)
CHCH 2(2)
CH2
CH2
1,2-dichloroethane
CH2
dichloromethane
CH3
diethyl ether
CH2
CH2
diglyme
CH2
OCH3
CH3
1,2-dimethoxyethane
CH2
CH3CO
dimethylacetamide
NCH3
NCH3
CH3
dimethyl carbonate
CH3
dimethyl malonate
CH2
dimethylformamide
CH
CH3
CH3
CH3
dimethyl sulfoxide
CH2
1,4-dioxane
CH3
ethane
CH3
ethanol
CH2
OH
CH3CO
ethyl acetate
CH 2CH3
CH2CH 3
CH3CO
ethyl methyl ketone
CH 2CH3
CH2CH 3
CH2
ethylene
CH2
ethylene glycol
furan
CH(2,5)
CH(3,4)
CH3
H grease8
CH2
CH3
hexamethylbenzene
CH3
hexamethyldisiloxane
S3
toluene-d 8
2.08
6.97
7.01
7.09
0.43
1.57
1.57
0.69
5.674
5.05
4.94
4.34
1.63
9.57
7.457.47
6.956.99
7.037.07
7.12
1.03
0.58
6.83
4.45
3.48
1.34
6.99
4.72
2.23
1.36
6.10
3.36
1.40
1.95
1.331.39
1.161.20
5.63
5.09
4.92
4.34
2.91
4.32
1.10
3.25
3.43
3.31
3.12
3.12
3.31
1.59
2.56
2.11
3.31
3.24
2.92
7.57
2.37
1.96
1.64
3.33
0.81
0.97
3.36
0.83
1.69
3.87
0.94
1.59
1.82
0.84
5.25
3.36
7.10
6.07
0.890.96
1.33
2.10
0.10
C6D6
7.16
C6D5Cl
6.96
6.99
7.14
0.40
1.52
1.55
0.58
5.684
5.06
4.94
4.38
1.63
9.64
7.497.53
6.936.99
7.017.07
7.15
1.05
0.63
6.93
4.53
3.48
1.41
7.05
4.79
2.24
1.38
6.15
3.39
1.40
1.98
1.281.37
1.081.16
5.65
5.09
4.92
4.38
2.90
4.27
1.11
3.26
3.46
3.34
3.11
3.12
3.33
1.60
2.57
2.05
3.30
3.23
2.97
7.63
2.36
1.86
1.68
3.35
0.80
0.96
3.34
0.50
1.65
3.89
0.92
1.58
1.81
0.85
5.25
3.41
7.13
6.08
0.900.98
1.32
2.13
0.12
1.03
1.76
1.77
1.21
5.77
5.15
5.04
4.44
1.80
9.77
7.597.61
7.157.19
7.247.28
7.20
1.12
1.30
6.83
4.62
3.61
1.37
6.97
5.50
2.20
1.37
6.74
3.41
1.37
2.08
1.481.53
1.331.37
5.75
5.17
5.03
4.46
3.26
4.77
1.10
3.31
3.49
3.37
3.16
3.17
3.37
1.74
2.65
2.42
3.48
3.41
3.15
7.73
2.51
2.30
2.03
3.45
0.79
1.06
3.51
1.39
1.78
3.96
1.04
1.78
2.06
0.89
5.29
3.58
7.24
6.19
0.860.92
1.30
2.10
0.10
(CD3)2CO (CD3)2SO
2.05
2.50
2.843
1.96
2.09
2.05
5.92
5.29
5.18
4.53
2.02
10.05
7.927.94
7.597.63
7.697.73
7.36
1.18
6.72
5.65
3.72
1.41
6.96
2.22
1.41
8.02
3.59
1.43
2.27
1.791.83
1.701.74
5.96
5.35
5.23
4.62
3.87
5.63
1.11
3.41
3.56
3.47
3.28
3.28
3.46
1.97
3.00
2.83
3.72
3.68
3.42
7.96
2.94
2.78
2.52
3.59
0.83
1.12
3.57
3.39
1.97
4.05
1.20
2.07
2.45
0.96
5.38
3.28
7.56
6.43
0.90
1.29
2.17
0.07
3.333
1.91
2.09
2.07
5.91
5.29
5.20
4.52
2.03
10.02
7.917.93
7.617.67
7.697.75
7.37
1.11
4.19
6.62
6.52
3.66
1.36
6.87
6.65
2.18
1.36
8.32
3.51
1.40
2.25
1.741.78
1.641.66
5.93
5.33
5.25
4.61
3.90
5.76
1.09
3.38
3.51
3.38
3.24
3.24
3.43
1.96
2.94
2.78
3.69
3.65
3.53
7.95
2.89
2.73
2.54
3.57
0.82
1.06
3.44
4.63
1.99
4.03
1.17
2.07
2.43
0.91
5.41
3.34
7.67
6.47
0.820.88
1.24
2.14
0.06
CD3CN
1.94
TFE-d 3
5.02
3.88
CD3OD
3.31
D2O
4.79
2.13
1.96
2.08
1.96
5.93
5.29
5.21
4.53
2.02
10.01
7.897.91
7.577.61
7.677.71
7.37
1.16
2.18
6.73
4.98
3.72
1.40
6.97
5.20
2.22
1.39
7.58
3.51
1.44
2.27
1.791.84
1.671.72
5.96
5.34
5.25
4.61
3.81
5.44
1.12
3.42
3.53
3.45
3.29
3.28
3.45
1.97
2.96
2.83
3.72
3.68
3.38
7.92
2.89
2.77
2.50
3.60
0.85
1.12
3.54
2.47
1.97
4.06
1.20
2.06
2.43
0.96
5.41
3.51
7.52
6.44
2.19
0.07
3.66
2.06
2.19
1.95
5.93
5.32
5.25
4.58
2.07
9.88
7.907.92
7.567.59
7.687.72
7.36
1.28
2.20
6.87
3.79
1.44
7.06
2.24
1.43
7.33
3.64
1.47
2.38
1.871.92
1.751.78
5.92
5.35
5.28
4.62
3.71
5.24
1.20
3.58
3.67
3.62
3.41
3.40
3.61
2.09
3.05
2.94
3.77
3.76
3.41
7.86
2.98
2.88
2.63
3.76
0.85
1.22
3.71
2.03
4.14
1.26
2.16
2.49
1.05
5.40
3.72
7.44
6.42
0.880.94
1.33
2.24
0.08
4.87
1.99
2.15
2.03
5.94
5.30
5.21
4.56
2.05
10.00
7.907.93
7.567.60
7.667.70
7.33
1.40
6.71
4.85
3.72
1.41
6.92
2.21
1.40
7.90
3.64
1.45
2.34
1.851.87
1.741.76
5.94
5.34
5.25
4.61
3.78
5.49
1.18
3.49
3.61
3.58
3.35
3.35
3.52
2.07
3.31
2.92
3.74
3.72
3.44
7.97
2.99
2.86
2.65
3.66
0.85
1.19
3.60
2.01
4.09
1.24
2.12
2.50
1.01
5.39
3.59
7.49
6.40
0.860.93
1.29
2.19
0.07
2.08
2.22
2.06
5.99
5.37
5.30
4.62
2.13
9.96
7.977.99
7.577.66
7.767.80
1.24
3.80
2.40
1.851.90
1.701.75
5.99
5.40
5.32
4.69
1.17
3.56
3.67
3.61
3.37
3.37
3.60
2.08
3.06
2.90
3.69
3.78
3.60
7.92
3.01
2.85
2.71
3.75
0.82
1.17
3.65
2.07
4.14
1.24
2.19
3.18
1.26
5.44
3.65
7.57
6.51
0.28
n -hexane
HMPA
hydrogen
imidazole
methane
methanol
nitromethane
n -pentane
propane
2-propanol
propylene
pump oil
pyridine
pyrrole
pyrrolidine10
silicone grease
tetrahydrofuran
toluene
triethylamine
0.88
0.89
0.85
CH3
t, 7
0.89
0.89
0.88
0.88
1.26
1.24
1.19
CH2
m
1.29
1.27
1.22
1.28
2.65
2.40
2.47
CH3
d, 9.5
2.58
2.60
2.42
2.59
4.62
4.47
4.49
H2
s
4.55
4.59
4.50
4.54
7.67
7.33
7.53
CH(2)
s
7.48
7.63
7.30
7.62
7.10
6.90
7.01
CH(4,5)
s
6.94
7.07
6.86
7.04
0.22
0.16
0.15
CH4
s
0.19
0.21
0.17
0.17
9
3.49
3.07
3.25
CH3
3.27
3.42
3.03
3.31
s
1.09
1.30
OH
3.02
1.09
3.12
s5,9
4.33
2.94
3.59
CH3
s
4.31
4.31
3.01
4.43
0.88
0.87
0.84
CH3
t, 7
0.89
0.89
0.87
0.88
1.27
1.23
1.23
CH2
m
1.31
1.30
1.25
1.27
0.90
0.86
0.84
CH3
t, 7.3
0.90
0.90
0.89
0.88
1.32
1.26
1.26
CH2
sept, 7.3
1.33
1.32
1.32
1.31
1.22
0.95
1.04
CH3
d, 6
1.08
1.17
0.95
1.10
4.04
3.67
3.82
CH
sept, 6
3.82
3.97
3.65
3.90
1.73
1.55
1.68
CH3
dt, 6.4, 1.5
1.69
1.71
1.55
1.58
4.94
4.95
4.90
CH2(1)
dm, 10
4.89
4.93
4.92
4.91
5.03
5.01
5.00
CH2(2)
dm, 17
4.99
5.03
4.98
4.98
5.83
5.72
5.81
CH
m
5.79
5.84
5.70
5.72
CH3
m
0.860.90 0.840.89 0.830.89 0.880.96 0.910.97 0.880.91
0.87
1.31
CH2
br s
1.29
1.27
1.26
1.30
1.37
1.29
8.51
CH(2,6)
m
8.54
8.59
8.62
8.47
8.53
8.58
6.90
CH(3,5)
m
7.25
7.28
7.29
6.67
6.66
7.35
7.25
CH(4)
m
7.65
7.68
7.68
6.99
6.98
7.76
8.61
NH
br t
9.96
8.69
8.40
7.71
7.80
10.02
6.62
CH(2,5)
m
6.66
6.79
6.83
6.43
6.48
6.77
6.27
CH(3,4)
m
6.02
6.19
6.26
6.27
6.37
6.07
CH2(2,5)
m
2.75
2.82
2.87
2.54
2.54
2.64
1.43
CH2(3,4)
m
1.59
1.67
1.68
1.36
1.33
0.14
CH3
s
0.11
0.09
0.07
0.26
0.29
0.13
3.59
CH2(2,5)
m
3.62
3.69
3.76
3.54
3.57
3.63
1.55
CH2(3,4)
m
1.79
1.82
1.85
1.43
1.40
1.79
2.16
CH3
s
2.31
2.34
2.36
2.11
2.11
2.32
7.017.08 7.107.20
CH(2,4,6)
m
7.10
7.15
7.17
6.967.01
7.02
7.107.17 7.107.20
CH(3,5)
m
7.19
7.24
7.25
7.09
7.13
0.93
CH3
t, 7
0.97
0.99
1.03
0.95
0.96
0.96
2.39
CH2
q, 7
2.46
2.48
2.53
2.39
2.40
2.45
S4
0.86
1.25
2.53
4.61
7.63
7.01
0.20
3.16
4.01
4.42
0.86
1.27
0.87
1.29
1.04
3.78
1.68
4.94
5.03
5.80
0.74
1.15
8.58
7.39
7.79
10.75
6.73
6.01
2.67
1.55
0.06
3.60
1.76
2.30
7.18
7.25
0.93
2.43
0.91
0.90
0.89
1.31
1.29
1.28
2.63
2.64
2.57
4.53
4.56
4.57
7.61
7.67
7.57
7.03
7.05
7.01
0.18
0.20
0.20
3.44
3.34
3.28
2.16
4.28
4.34
4.31
0.90
0.90
0.89
1.33
1.29
1.29
0.90
0.91
0.90
1.33
1.34
1.33
1.20
1.15
1.09
4.05
3.92
3.87
1.70
1.70
1.70
4.93
4.91
4.93
5.03
5.01
5.04
5.87
5.82
5.85
0.85
0.99
0.860.91
1.27
1.41
1.29
8.45
8.57
8.53
7.40
7.33
7.44
7.82
7.73
7.85
9.27
6.84
6.75
6.72
6.24
6.10
6.08
2.75
2.80
3.11
1.93
1.61
1.72
0.16
0.08
0.10
3.78
3.64
3.71
1.91
1.80
1.87
2.33
2.33
2.32
7.107.30 7.107.30
7.16
7.107.30 7.107.30
7.16
1.31
0.96
1.05
3.12
2.45
2.58
2.61
7.78
7.14
0.18
3.34
4.40
0.88
1.30
1.17
4.02
1.70
4.95
5.06
5.90
8.52
7.45
7.87
6.93
6.26
3.07
1.87
3.74
1.88
0.99
2.57
acetic acid
acetone
acetonitrile
allyl acetate
benzaldehyde
benzene
tert -butyl alcohol
BHA
BHT
carbon dioxide
carbon disulfide
carbon tetrachloride
chloroform
18-crown-6
cyclohexane
cyclohexanone
diallyl carbonate
1,2-dichloroethane
dichloromethane
diethyl ether
diglyme
1,2-dimethoxyethane
dimethylacetamide
dimethyl carbonate
dimethyl malonate
dimethylformamide
dimethyl sulfoxide
1,4-dioxane
ethane
ethanol
CO
CH3
CO
CH3
CN
CH3
CO
C HCH2
CHC H2
CH2
CH3
HCO
C(1)
CH(2,6)
CH(3,5)
CH (4)
CH
(CH3)3C
(C H3)3C
C(1)
C(2,6)
CH(3,5)
C(4)
CH3O
(C H3)3C
(CH3)3C
C(1)
C(2,6)
CH(3,5)
C(4)
CH3Ar
(C H3)3C
(CH3)3C
CO2
CS2
CCl4
CH
CH2
CH2
CO
CH2(2,6)
CH2(3,5)
CH2(4)
CO
C HCH2
CHC H2
CH2
CH2
CH2
CH3
CH2
CH3
CH2
CH2
CH3
CH2
CH3
CO
NCH3
NCH3
CO
CH3
CO2
CH3
CH2
CH
CH3
CH3
CH3
CH2
CH3
CH3
CH2
S5
THF-d 8
67.21
25.31
CD2Cl2
53.84
CDCl3
77.16
171.69
20.13
204.19
30.17
116.79
0.45
170.14
133.90
117.58
65.31
20.45
191.95
137.78
129.98
129.56
134.67
128.84
67.50
30.57
154.07
148.62
110.94
140.07
55.39
30.65
35.51
152.48
137.93
125.71
128.64
21.21
31.55
34.91
125.69
193.37
96.89
79.24
71.34
27.58
208.79
42.17
27.69
25.76
155.36
133.08
117.70
68.58
44.64
54.67
15.49
66.14
58.72
71.17
72.72
58.72
72.58
21.15
169.77
34.60
37.56
156.91
54.58
167.14
52.07
41.15
161.96
35.65
30.70
41.21
67.65
6.79
18.90
57.60
175.85
20.91
206.78
31.00
116.92
2.03
170.83
132.94
118.00
65.36
21.06
192.61
136.98
129.98
129.42
134.79
128.68
69.11
31.46
153.05
148.06
110.93
137.77
55.88
30.37
34.91
151.92
136.32
125.84
128.73
21.27
30.54
34.56
125.26
192.95
96.52
77.99
70.47
27.38
211.82
42.31
27.47
25.42
155.15
132.24
118.75
68.76
44.35
54.24
15.44
66.11
58.95
70.70
72.25
59.02
72.24
21.64
171.05
35.23
38.22
156.73
55.09
167.32
52.75
41.48
162.57
36.56
31.39
41.33
67.47
6.91
18.69
58.57
175.99
20.81
207.07
30.92
116.43
1.89
170.81
132.33
118.34
65.28
21.02
192.67
136.58
129.91
129.16
134.64
128.37
69.15
31.25
152.57
147.85
110.69
137.36
55.70
30.32
34.72
151.55
135.87
125.55
128.27
21.20
30.33
34.25
124.99
192.83
96.34
77.36
70.55
26.94
212.57
41.97
27.00
24.97
154.88
131.58
118.96
68.55
43.50
53.52
15.20
65.91
59.01
70.51
71.90
59.08
71.84
21.53
171.07
35.28
38.13
156.45
54.89
167.18
52.57
41.11
162.62
36.50
31.45
40.76
67.14
6.89
18.41
58.28
toluene-d 8
137.48
128.87
127.96
125.13
20.43
175.30
20.27
204.00
30.03
115.76
0.03
169.44
132.98
117.49
64.87
20.21
191.09
137.12
129.61
128.68
133.88
128.57
68.12
30.49
153.50
148.06
110.99
137.34
55.04
30.30
34.69
152.06
136.12
125.79
128.44
21.42
31.39
34.39
124.86
192.71
96.57
77.89
70.86
27.31
208.60
41.78
27.05
25.15
155.15
132.30
118.04
68.20
43.40
53.47
15.47
65.94
58.62
70.92
72.39
58.63
72.25
21.05
169.65
34.58
36.98
156.61
54.13
166.49
51.76
40.88
161.93
35.22
30.64
40.41
67.17
6.94
18.78
57.81
C6D6
128.06
C6D5Cl
134.19
129.26
128.25
125.96
(CD3)2CO
29.84
206.26
(CD3)2SO
39.52
CD3CN
1.32
118.26
TFE-d 3
61.50
126.28
CD3OD
49.00
D2O
-
175.82
20.37
204.43
30.14
116.02
0.20
169.67
132.90
117.64
64.92
20.37
191.43
137.05
129.65
128.95
133.95
128.62
68.19
30.47
153.62
148.13
111.15
137.50
55.27
30.35
34.72
152.05
136.08
125.83
128.52
21.40
31.34
34.35
124.76
192.69
96.44
77.79
70.59
27.23
209.10
41.83
27.00
25.03
155.24
132.18
118.22
68.28
43.59
53.46
15.46
65.94
58.66
70.87
72.35
58.68
72.21
21.16
169.95
34.67
37.03
156.71
54.30
166.66
51.86
41.04
162.13
35.25
30.72
40.03
67.16
6.96
18.72
57.86
175.67
20.40
204.83
30.12
115.93
0.63
169.59
132.69
117.63
64.86
20.40
191.24
136.78
129.49
128.87
134.02
128.38
68.19
31.13
153.19
147.87
110.84
137.29
55.08
30.21
34.56
151.69
135.92
125.58
128.26
21.10
30.19
34.11
126.08
192.49
96.38
77.67
70.55
26.99
209.30
41.79
27.02
25.07
154.87
131.93
118.22
68.19
43.60
53.54
15.35
65.79
58.42
70.56
72.07
58.31
71.81
21.03
169.79
34.59
37.13
156.36
54.23
166.51
51.89
40.93
162.01
35.45
30.71
40.27
66.95
6.91
18.55
57.63
172.31
20.51
205.87
30.60
117.60
1.12
170.61
133.76
117.81
65.28
20.68
192.95
137.66
130.23
129.90
135.14
129.15
68.13
30.72
153.97
148.48
111.00
140.32
55.51
30.64
35.45
152.51
138.19
126.03
129.05
21.31
31.61
35.00
125.81
193.58
96.65
79.19
71.25
27.51
210.36
42.24
27.68
25.59
155.48
133.16
118.53
68.78
45.25
54.95
15.78
66.12
58.77
71.03
72.63
58.45
72.47
21.51
170.61
34.89
37.92
157.04
54.95
167.58
52.47
41.43
162.79
36.15
31.03
41.23
67.60
6.88
18.89
57.72
171.93
20.95
206.31
30.56
117.91
1.03
169.97
132.71
117.64
64.32
20.54
193.08
136.20
129.45
129.10
134.52
128.30
66.88
30.38
152.53
147.44
109.80
141.16
54.89
30.30
34.76
151.47
139.12
124.85
127.97
20.97
31.25
34.33
124.21
192.63
95.44
79.16
69.85
26.33
210.63
41.32
26.46
24.32
154.16
132.18
118.32
67.86
45.02
54.84
15.12
62.05
57.98
69.54
71.25
58.03
71.17
21.29
169.54
34.42
37.38
155.76
54.63
166.91
52.08
40.72
162.29
35.73
30.73
40.45
66.36
6.61
18.51
56.07
173.21
20.73
207.43
30.91
118.26
1.79
171.32
133.83
118.06
65.55
21.02
193.64
137.62
130.42
130.07
135.40
129.32
68.74
30.68
154.02
148.39
111.35
140.20
55.94
30.55
35.48
152.42
138.13
126.38
129.61
21.23
31.50
35.05
125.89
193.60
96.68
79.17
71.22
27.63
211.99
42.44
27.80
25.62
155.66
133.20
118.86
69.09
45.54
55.32
15.63
66.32
58.90
70.99
72.63
58.89
72.47
21.76
171.31
35.17
38.26
157.26
55.39
168.07
52.95
41.77
163.31
36.57
31.32
41.31
67.72
6.99
18.80
57.96
177.96
20.91
32.35
214.98
118.95
1.00
175.98
133.33
119.39
67.61
21.10
197.63
137.84
131.78
130.82
137.17
129.84
72.35
31.07
153.74
150.52
112.90
140.23
57.55
30.80
36.07
153.46
138.59
127.11
130.62
21.34
31.01
35.69
126.92
196.26
97.74
78.83
70.80
28.34
221.30
43.16
28.56
26.00
157.39
132.72
120.15
70.69
45.28
54.46
15.33
67.55
59.40
73.05
71.33
59.52
72.87
21.40
175.74
36.28
39.06
159.04
56.17
170.88
54.00
42.13
166.01
37.76
30.96
40.06
68.52
7.01
18.11
59.68
175.11
20.56
209.67
30.67
118.06
0.85
172.41
133.71
118.22
66.14
20.71
194.11
137.96
130.64
130.12
135.60
129.34
69.40
30.91
154.34
149.04
111.30
141.36
55.96
30.82
35.83
152.85
139.09
126.11
129.49
21.38
31.15
35.36
126.31
193.82
97.21
79.44
71.47
27.96
214.69
42.61
28.16
25.86
156.28
133.25
118.74
69.35
45.11
54.78
15.46
66.88
59.06
71.33
72.92
59.06
72.72
21.32
173.32
35.50
38.43
157.91
55.25
168.70
52.83
41.60
164.73
36.89
31.61
40.45
68.11
6.98
18.40
58.26
177.21
21.03
215.94
30.89
119.68
1.47
174.78
132.48
119.03
66.52
21.00
191.67
136.11
130.09
129.48
134.70
70.36
30.29
197.25
96.73
70.14
221.22
42.02
27.50
24.77
157.78
132.76
118.75
68.81
14.77
66.42
58.67
70.05
71.63
58.67
71.49
21.09
174.57
35.03
38.76
163.96
55.81
170.12
53.65
42.13
165.53
37.54
32.03
39.39
67.19
17.47
58.05
C H3CO
CO
CH2
CH3
C H3CO
ethyl methyl ketone
CO
C H2CH3
CH2C H3
CH2
ethylene
CH2
ethylene glycol
furan
CH(2,5)
CH(3,4)
CH2
H grease8
hexamethylbenzene
C
CH3
CH3
hexamethyldisiloxane
CH3
n -hexane
CH2(2,5)
CH2(3,4)
HMPA11
CH3
imidazole
CH(2)
CH(4,5)
CH4
methane
CH3
methanol
CH3
nitromethane
CH3
n -pentane
CH2(2,4)
CH2(3)
CH3
propane
CH2
CH3
2-propanol
CH
CH3
propylene
CH2
CH
CH2
pump oil
pyridine
CH(2,6)
CH(3,5)
CH(4)
pyrrole
CH(2,5)
CH(3,4)
pyrrolidine10
CH2(2,5)
CH2(3,4)
CH3
silicone grease
CH2(2,5)
tetrahydrofuran
CH2(3,4)
CH3
toluene
C(1)
CH(2,6)
CH(3,5)
CH(4)
CH3
triethylamine
CH2
ethyl acetate
S6
20.45
170.32
60.30
14.37
28.92
207.05
36.59
7.87
123.09
64.35
143.26
109.88
30.45
131.88
16.71
1.83
14.22
23.33
32.34
36.89
135.72
122.20
4.90
49.64
62.49
14.18
23.00
34.87
16.60
16.82
25.70
66.14
19.27
115.74
134.02
30.63
150.57
124.08
135.99
118.03
107.74
45.82
26.17
1.20
68.03
26.19
21.29
138.24
129.47
128.71
125.84
12.51
47.18
21.15
171.24
60.63
14.37
29.55
209.57
37.01
7.94
123.20
64.08
142.98
109.86
30.14
132.09
16.93
1.96
14.28
23.07
32.01
36.99
135.76
122.16
4.33
50.45
63.03
14.24
22.77
34.57
16.63
16.63
25.43
64.67
19.47
115.70
134.21
30.13
150.27
124.06
136.16
117.93
108.02
47.02
25.83
1.22
68.16
25.98
21.53
138.36
129.35
128.54
125.62
12.12
46.75
21.04
171.36
60.49
14.19
29.49
209.56
36.89
7.86
123.13
63.79
142.71
109.57
29.71
132.21
16.98
1.97
14.14
22.70
31.64
36.87
135.38
122.00
4.63
50.41
62.50
14.08
22.38
34.16
16.63
16.37
25.14
64.50
19.50
115.74
133.91
29.84
149.90
123.75
135.96
117.77
107.98
46.93
25.56
1.19
67.97
25.62
21.46
137.89
129.07
128.26
125.33
11.61
46.25
20.46
170.02
60.08
14.23
28.74
206.31
36.32
7.89
122.92
64.29
142.65
109.63
30.31
131.72
16.84
1.99
14.34
23.12
32.06
36.80
135.57
122.13
4.34
49.90
61.14
14.27
22.79
34.54
16.65
16.63
25.24
64.12
19.32
115.89
133.61
30.33
150.25
123.46
135.17
117.61
108.15
47.12
25.75
1.37
67.75
25.79
21.37
137.84
129.33
128.51
125.66
12.39
46.82
20.56
170.44
60.21
14.19
28.56
206.55
36.36
7.91
122.96
64.34
142.73
109.67
30.22
131.79
16.95
2.05
14.32
23.04
31.96
36.88
135.76
122.16
4.29
49.97
61.16
14.25
22.72
34.45
16.66
16.60
25.18
64.23
19.38
115.92
133.69
30.24
150.27
123.58
135.28
117.78
108.21
46.86
25.65
1.38
67.80
25.72
21.10
137.91
129.33
128.56
125.68
12.35
46.77
20.50
170.20
60.06
14.07
28.82
206.87
36.39
7.79
122.95
64.03
142.49
109.64
30.11
131.54
16.68
1.92
14.18
22.86
31.77
36.64
135.50
121.96
4.33
49.66
61.68
14.10
22.54
34.26
16.56
16.48
25.14
64.18
19.32
115.86
133.57
30.11
149.93
123.49
135.32
117.65
108.03
46.75
25.59
1.09
67.64
25.68
21.23
137.65
129.12
128.31
125.43
11.87
46.36
20.83
170.96
60.56
14.50
29.30
208.30
36.75
8.03
123.47
64.26
143.49
110.24
132.22
16.86
2.01
14.34
23.28
32.30
37.04
135.89
122.31
5.33
49.77
63.21
14.29
22.98
34.83
16.68
16.78
25.67
63.85
19.42
116.03
134.34
30.36
150.67
124.57
136.56
117.98
108.04
1.40
68.07
26.15
21.46
138.48
129.76
129.03
126.12
12.49
47.07
20.68
170.31
59.74
14.40
29.26
208.72
35.83
7.61
123.52
62.76
142.82
109.62
131.10
16.60
1.96
13.88
22.05
30.95
36.42
135.15
121.55
4.01
48.59
63.28
13.28
21.70
33.48
16.34
15.67
25.43
64.92
19.20
116.07
133.55
29.33
149.58
123.84
136.05
117.32
107.07
46.51
25.26
67.03
25.14
20.99
137.35
128.88
128.18
125.29
11.74
45.74
21.16
171.68
60.98
14.54
29.60
209.88
37.09
8.14
123.69
64.22
143.74
110.49
132.61
16.94
2.07
14.43
23.40
32.36
37.10
136.33
122.78
4.61
49.90
63.66
14.37
23.08
34.89
16.73
16.91
25.55
64.30
19.48
116.12
134.78
30.86
150.76
127.76
136.89
118.47
108.31
47.57
26.34
68.33
26.27
21.50
138.90
129.94
129.23
126.28
12.38
47.10
21.18
175.55
62.70
14.36
29.64
218.31
38.23
8.29
124.08
64.87
144.22
111.06
134.04
17.04
2.09
14.63
24.06
33.17
37.21
136.58
122.93
5.88
50.67
63.17
14.54
23.75
35.76
16.93
17.46
25.21
66.69
19.63
116.38
136.00
31.85
149.76
126.27
139.62
119.61
108.85
47.43
25.73
2.87
69.53
26.69
21.62
139.92
130.58
129.79
126.82
9.51
48.45
20.88
172.89
61.50
14.49
29.39
212.16
37.34
8.09
123.46
64.30
143.68
110.33
132.53
16.90
1.99
14.45
23.68
32.73
37.00
136.31
122.60
4.90
49.86
63.08
14.39
23.38
35.30
16.80
17.19
25.27
64.71
19.50
116.04
134.61
31.35
150.07
125.53
138.35
118.28
108.11
47.23
26.29
2.10
68.83
26.48
21.50
138.85
129.91
129.20
126.29
11.09
46.96
21.15
175.26
62.32
13.92
29.49
218.43
37.27
7.87
63.17
143.57
110.23
2.31
36.46
136.65
122.43
49.5012
63.22
24.38
64.88
149.18
125.12
138.27
119.06
107.83
46.83
25.86
68.68
25.67
9.07
47.19
mult
proton
s
CH3
s
CH3
s
CH4
s
CH3
m
CH3
m
CH3
t, 7
CH3
t, 7
CH3
t, 7.3
CH3
t, 7
CH2CH3
t, 7
CH3
d, 6
CH3
t, 7
CH3
t, 7
CH3
s
CH3
t, 7
CH2CH3
br s
CH2
m
CH2
br s
CH2
m
CH2
sept, 7.3
CH2
s
ArC(CH3)3
s
ArC(CH3)3
s
CH2
m
CH2(3,4)
m
CH2(4)
dt, 6.4, 1.5
CH3
m
CHD(3,4)
m
CH2(3,5)
m
CH2(3,4)
s
CH3
s
CH3CO
s
CH3CO
s
CH3
s
CH3
s
CH3CO
s
CH3
s
CH3
impurity
shift
mult
proton
impurity
shift
mult
proton
impurity
hexamethyldisiloxane
silicone grease
methane
ethane
H grease8
pump oil
n-hexane
n-pentane
propane
ethyl methyl ketone
triethylamine
2-propanol
ethanol
diethyl ether
tert-butyl alcohol
ethyl acetate
H grease8
n-hexane
pump oil
n-pentane
propane
BHA
BHT
cyclohexane
pyrrolidine
cyclohexanone
propylene
THF-d8 residual
cyclohexanone
tetrahydrofuran
acetic acid
dimethylacetamide
ethyl acetate
acetonitrile
allyl acetate
ethyl methyl ketone
acetone
hexamethylbenzene
2.21
2.24
2.31
2.39
2.45
2.46
2.46
2.58
2.75
2.76
2.82
2.88
2.95
3.02
3.16
3.27
3.28
3.28
3.30
3.35
3.38
3.43
3.43
3.48
3.51
3.53
3.56
3.57
3.58
3.62
3.65
3.68
3.69
3.77
3.82
4.04
4.31
s
t
s
q, 7
s
s
q, 7
d, 9.5
m
s
s
s
s
s9
s
s9
s
s
s6
s
q, 7
m
s
s
q, 76
m
s
s
m
m
s
s
s
s
sept, 6
q, 7
s
ArCH3
CH2(2,6)
CH3
CH2CH3
CH3
OH
CH2
CH3
CH2(2,5)
CH3
NCH3
CH3
NCH3
OH
OH
CH3
OCH3
CH3
OH
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CHD(2,5)
CH2(2,5)
CH3
ArOCH3
CH3
CH2
CH
CH2CH3
CH3
BHT
cyclohexanone
toluene
ethyl methyl ketone
dimethyl sulfoxide
water
triethylamine
HMPA
pyrrolidine
dimethylformamide
dimethylacetamide
dimethylformamide
dimethylacetamide
methanol
tert-butyl alcohol
methanol
diglyme
1,2-dimethoxyethane
ethanol
dimethyl malonate
diethyl ether
diglyme
1,2-dimethoxyethane
ethylene glycol
ethanol
diglyme
1,4-dioxane
18-crown-6
THF-d8 residual
tetrahydrofuran
dimethyl malonate
BHA
dimethyl carbonate
1,2-dichloroethane
2-propanol
ethyl acetate
nitromethane
4.50
4.55
4.58
4.89
4.99
5.15
5.19
5.27
5.31
5.36
5.51
5.64
5.79
5.81
5.90
5.92
6.02
6.37
6.66
6.68
6.92
6.94
7.10
7.19
7.25
7.31
7.48
7.48
7.517.55
7.607.64
7.65
7.867.88
7.89
7.91
8.54
9.96
9.98
ddd
s
ddd
dm, 10
dm, 17
ddt
ddt
ddt
ddt
s
s
s
m
s
ddt
ddt
m
dd
m
s
s
s
m
m
m
s
dd
s
m
m
m
m
s
s
m
br t
s
CH2
H2
CH2
CH2(1)
CH2(2)
CHCH2(2)
CHCH2(2)
CHCH2(1)
CHCH2(1)
CH2
CH2
OH
CH
OH
CHCH2
CHCH2
CH(3,4)
CH(3,4)
CH(2,5)
ArH
ArH
CH(4,5)
CH(2,4,6)
CH(3,5)
CH(3,5)
CH
CH(2,5)
CH(2)
CH(3,5)
CH(4)
CH(4)
CH(2,6)
CH
CH
CH(2,6)
NH
HCO
allyl acetate
hydrogen
diallyl carbonate
propylene
propylene
allyl acetate
diallyl carbonate
allyl acetate
diallyl carbonate
ethylene
dichloromethane
BHA
propylene
BHT
allyl acetate
diallyl carbonate
pyrrole
furan
pyrrole
BHA
BHT
imidazole
toluene
toluene
pyridine
benzene
furan
imidazole
benzaldehyde
benzaldehyde
pyridine
benzaldehyde
chloroform
dimethylformamide
pyridine
pyrrole
benzaldehyde
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
4.90
0.45
1.20
1.83
6.79
7.87
12.51
14.18
14.22
14.37
15.49
16.60
16.71
16.82
18.90
19.27
20.13
20.45
20.45
21.15
21.21
21.29
23.00
23.33
25.31 (p)
25.70
25.76
26.17
26.19
27.58
27.69
28.92
CH4
CH3
CH3
CH3
CH3
CH2CH3
CH3
CH3
CH3
CH3
CH3
CH3
CH3
CH2
CH3
CH3
CH3
CH3
CH3CO
CH3
CH3Ar
CH3
CH2(2,4)
CH2(2,5)
CD2(3,4)
CH3
CH2(4)
CH2(3,4)
CH2(3,4)
CH2
CH2(3,5)
CH3CO
methane
acetonitrile
silicone grease
hexamethyldisiloxane
ethane
ethyl methyl ketone
triethylamine
n-pentane
n-hexane
ethyl acetate
diethyl ether
propane
hexamethylbenzene
propane
ethanol
propylene
acetic acid
allyl acetate
ethyl acetate
dimethylacetamide
BHT
toluene
n-pentane
n-hexane
THF-d8 signal
2-propanol
cyclohexanone
pyrrolidine
tetrahydrofuran
cyclohexane
cyclohexanone
ethyl methyl ketone
30.17
30.45
30.57
30.63
30.65
30.70
31.55
32.34
34.60
34.87
34.91
35.51
35.65
36.59
36.89 (d)
37.56
41.15
41.21
42.17
44.64
45.82
47.18
49.64
52.07
54.58
54.67
55.39
57.60
58.72
58.72
60.30
62.49
CH3
CH2
(CH3)3C
CH2
(CH3)3C
CH3
(CH3)3C
CH2(3,4)
NCH3
CH2(3)
(CH3)3C
(CH3)3C
CH3
CH2CH3
CH3
NCH3
CH2
CH3
CH2(2,6)
CH2
CH2(2,5)
CH2
CH3
CH3
CH3
CH2
CH3O
CH2
CH3
CH3
CH2
CH3
acetone
H grease8
tert-butyl alcohol
pump oil
BHA
dimethylformamide
BHT
n-hexane
dimethylacetamide
n-pentane
BHT
BHA
dimethylformamide
ethyl methyl ketone
HMPA11
dimethylacetamide
dimethyl malonate
dimethyl sulfoxide
cyclohexanone
1,2-dichloroethane
pyrrolidine
triethylamine
methanol
dimethyl malonate
dimethyl carbonate
dichloromethane
BHA
ethanol
diglyme
1,2-dimethoxyethane
ethyl acetate
nitromethane
64.35
65.31
66.14
66.14
67.21 (p)
67.50
67.65
68.03
68.58
71.17
71.34
72.58
72.72
79.24
96.89
107.74
109.88
110.94
115.74
116.79
117.58
117.70
118.03
122.20
123.09
124.08
125.69
125.71
125.84
128.64
128.71
128.84
CH2
CH2
CH2
CH
CD2(2,5)
(CH3)3C
CH2
CH2(2,5)
CH2
CH2
CH2
CH2
CH2
CH
CCl4
CH(3,4)
CH(3,4)
CH(3,5)
CH2
CN
CHCH2
CHCH2
CH(2,5)
CH(4,5)
CH2
CH(3,5)
CO2
CH(3,5)
CH(4)
C(4)
CH(3,5)
CH
ethylene glycol
allyl acetate
diethyl ether
2-propanol
THF-d8 signal
tert-butyl alcohol
1,4-dioxane
tetrahydrofuran
diallyl carbonate
diglyme
18-crown-6
1,2-dimethoxyethane
diglyme
chloroform
carbon tetrachloride
pyrrole
furan
BHA
propylene
acetonitrile
allyl acetate
diallyl carbonate
pyrrole
imidazole
ethylene
pyridine
carbon dioxide
BHT
toluene
BHT
toluene
benzene
129.47
129.56
129.98
131.88
133.08
133.90
134.02
134.67
135.72
135.99
137.78
137.93
138.24
140.07
143.26
148.62
150.57
152.48
154.07
155.36
156.91
161.96
167.14
169.77
170.14
170.32
171.69
191.95
193.37
204.19
207.05
208.79
CH(2,6)
CH(3,5)
CH(2,6)
C
CHCH2
CHCH2
CH
CH (4)
CH(2)
CH(4)
C(1)
C(2,6)
C(1)
C(4)
CH(2,5)
C(2,6)
CH(2,6)
C(1)
C(1)
CO
CO
CH
CO2
CO
CO
CO
CO
HCO
CS2
CO
CO
CO
toluene
benzaldehyde
benzaldehyde
hexamethylbenzene
diallyl carbonate
allyl acetate
propylene
benzaldehyde
imidazole
pyridine
benzaldehyde
BHT
toluene
BHA
furan
BHA
pyridine
BHT
BHA
diallyl carbonate
dimethyl carbonate
dimethylformamide
dimethyl malonate
dimethylacetamide
allyl acetate
ethyl acetate
acetic acid
benzaldehyde
carbon disulfide
acetone
ethyl methyl ketone
cyclohexanone
S7
mult
0.07
0.09
0.21
0.840.89
0.840.90
0.85
0.89
0.89
0.90
0.99
1.00
1.09
1.15
1.17
1.19
1.23
1.24
1.27
1.27
1.27
1.30
1.32
1.33
1.42
1.42
1.44
1.52
1.691.72
1.67
1.71
1.811.87
1.82
1.97
2.00
2.02
2.05
2.06
proton
s
CH3
s
CH3
s
CH4
m
CH3
m
CH3
s
CH3
t, 7
CH3
t, 7
CH3
t, 7.3
CH3
t, 7
CH3
t, 7
CH2CH3
s9
OH
t, 7
CH3
d, 6
CH3
t, 7
CH3
t, 7
CH2CH3
s
CH3
br s
CH2
m
CH2
br s
CH2
m
CH2
sept, 7.3
CH2
s6
OH
s
ArC(CH3)3
s
ArC(CH3)3
s
CH2
s
OH
m
CH2(4)
m
CH2(3,4)
dt, 6.4, 1.5
CH3
m
CH2(3,5)
m
CH2(3,4)
s
CH3
s
CH3CO
s
CH3CO
s
CH3
s
CH3
impurity
shift
mult
proton
impurity
shift
mult
proton
impurity
hexamethyldisiloxane
silicone grease
methane
pump oil
H grease8
ethane
n-hexane
n-pentane
propane
triethylamine
ethyl methyl ketone
methanol
diethyl ether
2-propanol
ethanol
ethyl acetate
tert-butyl alcohol
H grease8
n-hexane
pump oil
n-pentane
propane
ethanol
BHA
BHT
cyclohexane
water
cyclohexanone
pyrrolidine
propylene
cyclohexanone
tetrahydrofuran
acetonitrile
ethyl acetate
dimethylacetamide
allyl acetate
acetic acid
2.09
2.12
2.20
2.25
2.29
2.34
2.43
2.48
2.55
2.60
2.82
2.82
2.87
2.91
2.97
3.33
3.34
3.37
3.42
3.43
3.49
3.50
3.57
3.59
3.65
3.66
3.66
3.69
3.72
3.73
3.75
3.76
3.97
4.08
4.31
4.55
4.59
s
s
s
s
t
s
q, 7
q, 7
s
d, 9.5
s
m
s
s
s
s
s
s
s9
q, 7
s
m
m
s
s
q, 76
s
m
s
s
s
s
sept, 6
q, 7
s
ddd
s
CH3CO
CH3
CH3
ArCH3
CH2(2,6)
CH3
CH2CH3
CH2
CH3
CH3
CH3
CH2(2,5)
NCH3
CH3
NCH3
OCH3
CH3
CH2
CH3
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH2(2,5)
CH3
ArOCH3
CH3
CH2
CH
CH2CH3
CH3
CH2
H2
4.61
4.76
4.93
5.00
5.03
5.22
5.26
5.31
5.32
5.33
5.35
5.40
5.84
5.92
5.95
6.19
6.41
6.73
6.79
6.97
7.07
7.15
7.24
7.28
7.32
7.35
7.46
7.537.57
7.63
7.637.67
7.68
7.877.89
7.96
8.59
8.69
10.01
ddd
s
dm, 10
s
dm, 17
ddt
ddt
ddt
t
s
ddt
s
m
ddt
ddt
m
dd
s
m
s
s
m
m
m
s
s
dd
m
s
m
m
m
s
m
br t
s
CH2
OH
CH2(1)
OH
CH2(2)
CHCH2(2)
CHCH2(2)
CHCH2(1)
CDHCl2
CH2
CHCH2(1)
CH2
CH
CHCH2
CHCH2
CH(3,4)
CH(3,4)
ArH
CH(2,5)
ArH
CH(4,5)
CH(2,4,6)
CH(3,5)
CH(3,5)
CH
CH
CH(2,5)
CH(3,5)
CH(2)
CH(4)
CH(4)
CH(2,6)
CH
CH(2,6)
NH
HCO
diallyl carbonate
BHA
propylene
BHT
propylene
allyl acetate
diallyl carbonate
allyl acetate
CD2Cl2 residual
dichloromethane
diallyl carbonate
ethylene
propylene
allyl acetate
diallyl carbonate
pyrrole
furan
BHA
pyrrole
BHT
imidazole
toluene
toluene
pyridine
chloroform
benzene
furan
benzaldehyde
imidazole
benzaldehyde
pyridine
benzaldehyde
dimethylformamide
pyridine
pyrrole
benzaldehyde
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
4.33
1.22
1.96
2.03
6.91
7.94
12.12
14.24
14.28
14.37
15.44
16.63
16.63
16.93
18.69
19.47
20.91
21.06
21.15
21.27
21.53
21.64
22.77
23.07
25.42
25.43
25.83
25.98
27.38
27.47
29.55
30.13
CH4
CH3
CH3
CH3
CH3
CH2CH3
CH3
CH3
CH3
CH3
CH3
CH3
CH2
CH3
CH3
CH3
CH3
CH3
CH3CO
CH3Ar
CH3
CH3
CH2(2,4)
CH2(2,5)
CH2(4)
CH3
CH2(3,4)
CH2(3,4)
CH2
CH2(3,5)
CH3CO
CH2
methane
silicone grease
hexamethyldisiloxane
acetonitrile
ethane
ethyl methyl ketone
triethylamine
n-pentane
n-hexane
ethyl acetate
diethyl ether
propane
propane
hexamethylbenzene
ethanol
propylene
acetic acid
allyl acetate
ethyl acetate
BHT
toluene
dimethylacetamide
n-pentane
n-hexane
cyclohexanone
2-propanol
pyrrolidine
tetrahydrofuran
cyclohexane
cyclohexanone
ethyl methyl ketone
pump oil
30.14
30.37
30.54
31.00
31.39
31.46
32.01
34.56
34.57
34.91
35.23
36.56
36.99 (d)
37.01
38.22
41.33
41.48
42.31
44.35
46.75
47.02
50.45
52.75
53.84 (p)
54.24
55.09
55.88
58.57
58.95
59.02
60.63
63.03
CH2
(CH3)3C
(CH3)3C
CH3
CH3
(CH3)3C
CH2(3,4)
(CH3)3C
CH2(3)
(CH3)3C
NCH3
CH3
CH3
CH2CH3
NCH3
CH3
CH2
CH2(2,6)
CH2
CH2
CH2(2,5)
CH3
CH3
CD2Cl2
CH2
CH3
CH3O
CH2
CH3
CH3
CH2
CH3
H grease8
BHA
BHT
acetone
dimethylformamide
tert-butyl alcohol
n-hexane
BHT
n-pentane
BHA
dimethylacetamide
dimethylformamide
HMPAi
ethyl methyl ketone
dimethylacetamide
dimethyl sulfoxide
dimethyl malonate
cyclohexanone
1,2-dichloroethane
triethylamine
pyrrolidine
methanol
dimethyl malonate
CD2Cl2 signal
dichloromethane
dimethyl carbonate
BHA
ethanol
diglyme
1,2-dimethoxyethane
ethyl acetate
nitromethane
64.08
64.67
65.36
66.11
67.47
68.16
68.76
69.11
70.47
70.70
72.24
72.25
77.99
96.52
108.02
109.86
110.93
115.7
116.92
117.93
118.00
118.75
122.16
123.20
124.06
125.26
125.62
125.84
128.54
128.68
128.73
129.35
CH2
CH
CH2
CH2
CH2
CH2(2,5)
CH2
(CH3)3C
CH2
CH2
CH2
CH2
CH
CCl4
CH(3,4)
CH(3,4)
CH(3,5)
CH2
CN
CH(2,5)
CHCH2
CHCH2
CH(4,5)
CH2
CH(3,5)
CO2
CH(4)
CH(3,5)
CH(3,5)
CH
C(4)
CH(2,6)
ethylene glycol
2-propanol
allyl acetate
diethyl ether
1,4-dioxane
tetrahydrofuran
diallyl carbonate
tert-butyl alcohol
18-crown-6
diglyme
1,2-dimethoxyethane
diglyme
chloroform
carbon tetrachloride
pyrrole
furan
BHA
propylene
acetonitrile
pyrrole
allyl acetate
diallyl carbonate
imidazole
ethylene
pyridine
carbon dioxide
toluene
BHT
toluene
benzene
BHT
toluene
129.42
129.98
132.09
132.24
132.94
134.21
134.79
135.76
136.16
136.32
136.98
137.77
138.36
142.98
148.06
150.27
151.92
153.05
155.15
156.73
162.57
167.32
170.83
171.05
171.24
175.85
192.61
192.95
206.78
209.57
211.82
CH(3,5)
CH(2,6)
C
CHCH2
CHCH2
CH
CH (4)
CH(2)
CH(4)
C(2,6)
C(1)
C(4)
C(1)
CH(2,5)
C(2,6)
CH(2,6)
C(1)
C(1)
CO
CO
CH
CO2
CO
CO
CO
CO
HCO
CS2
CO
CO
CO
benzaldehyde
benzaldehyde
hexamethylbenzene
diallyl carbonate
allyl acetate
propylene
benzaldehyde
imidazole
pyridine
BHT
benzaldehyde
BHA
toluene
furan
BHA
pyridine
BHT
BHA
diallyl carbonate
dimethyl carbonate
dimethylformamide
dimethyl malonate
allyl acetate
dimethylacetamide
ethyl acetate
acetic acid
benzaldehyde
carbon disulfide
acetone
ethyl methyl ketone
cyclohexanone
S8
mult
0.07
0.07
0.22
0.830.89
0.840.87
0.87
0.88
0.88
0.90
1.03
1.06
1.09
1.21
1.22
1.25
1.25
1.26
1.26
1.26
1.27
1.28
1.32
1.32
1.43
1.43
1.44
1.56
1.68
1.711.73
1.73
1.841.86
1.85
2.05
2.09
2.09
2.10
2.10
proton
s
CH3
s
CH3
s
CH4
m
CH3
m
CH3
s
CH3
t, 7
CH3
t, 7
CH3
t, 7.3
CH3
t, 7
CH3
t, 7
CH2CH3
s9
OH
t, 7
CH3
d, 6
CH3
t, 7
CH3
br s
CH2
t, 7
CH2CH3
m
CH2
br s
CH2
m
CH2
s
CH3
s6
OH
sept, 7.3
CH2
s
ArC(CH3)3
s
CH2
s
ArC(CH3)3
s
OH
m
CH2(3,4)
m
CH2(4)
dt, 6.4, 1.5
CH3
m
CH2(3,5)
m
CH2(3,4)
s
CH3CO
s
CH3
s
CH3CO
s
CH3
s
CH3
impurity
shift
mult
proton
impurity
shift
mult
proton
impurity
hexamethyldisiloxane
silicone grease
methane
pump oil
H grease8
ethane
n-hexane
n-pentane
propane
triethylamine
ethyl methyl ketone
methanol
diethyl ether
2-propanol
ethanol
H grease8
ethyl acetate
n-hexane
pump oil
n-pentane
tert-butyl alcohol
ethanol
propane
BHT
cyclohexane
BHA
water
pyrrolidine
cyclohexanone
propylene
cyclohexanone
tetrahydrofuran
ethyl acetate
allyl acetate
dimethylacetamide
acetic acid
acetonitrile
2.14
2.17
2.24
2.27
2.33
2.36
2.46
2.53
2.62
2.65
2.87
2.88
2.94
2.96
3.02
3.39
3.40
3.40
3.48
3.49
3.55
3.57
3.65
3.67
3.71
3.72
3.73
3.75
3.76
3.76
3.77
3.79
4.04
4.12
4.33
4.57
4.62
s
s
s
s
t
s
q, 7
q, 7
s
d, 9.5
m
s
s
s
s
s
s
s
q, 7
s9
s
m
m
s
s
q, 79
s
s
s
m
s
s
sept, 6
q, 7
s
ddd
s
CH3CO
CH3
CH3
ArCH3
CH2(2,6)
CH3
CH2CH3
CH2
CH3
CH3
CH2(2,5)
CH3
NCH3
CH3
NCH3
OCH3
CH3
CH2
CH2
CH3
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH3
CH2
CH2(2,5)
ArOCH3
CH3
CH
CH2CH3
CH3
CH2
H2
4.64
4.76
4.94
5.01
5.03
5.24
5.27
5.30
5.32
5.37
5.40
5.83
5.93
5.94
6.26
6.40
6.76
6.83
6.98
7.10
7.17
7.25
7.26
7.26
7.29
7.36
7.45
7.517.57
7.617.65
7.67
7.68
7.887.91
8.02
8.40
8.62
10.03
ddd
s
dm, 10
s
dm, 17
ddt
ddt
s
ddt
ddt
s
m
ddt
ddt
m
dd
s
m
s
s
m
m
s
s
m
s
dd
m
m
s
m
m
s
br t
m
s
CH2
OHd
CH2(1)
OHd
CH2(2)
CHCH2(2)
CHCH2(2)
CH2
CHCH2(1)
CHCH2(1)
CH2
CH
CHCH2
CHCH2
CH(3,4)
CH(3,4)
ArH
CH(2,5)
ArH
CH(4,5)
CH(2,4,6)
CH(3,5)
CH
CH
CH(3,5)
CH
CH(2,5)
CH(3,5)
CH(4)
CH(2)
CH(4)
CH(2,6)
CH
NH
CH(2,6)
HCO
diallyl carbonate
BHA
propylene
BHT
propylene
allyl acetate
diallyl carbonate
dichloromethane
allyl acetate
diallyl carbonate
ethylene
propylene
allyl acetate
diallyl carbonate
pyrrole
furan
BHA
pyrrole
BHT
imidazole
toluene
toluene
CDCl3 residual
chloroform
pyridine
benzene
furan
benzaldehyde
benzaldehyde
imidazole
pyridine
benzaldehyde
dimethylformamide
pyrrole
pyridine
benzaldehyde
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
4.63
1.19
1.89
1.97
6.89
7.86
11.61
14.08
14.14
14.19
15.20
16.37
16.63
16.98
18.41
19.50
20.81
21.02
21.04
21.20
21.46
21.53
22.38
22.70
24.97
25.14
25.56
25.62
26.94
27.00
29.49
29.71
CH4
CH3
CH3
CH3
CH3
CH2CH3
CH3
CH3
CH3
CH3
CH3
CH2
CH3
CH3
CH3
CH3
CH3
CH3
CH3CO
CH3Ar
CH3
CH3
CH2(2,4)
CH2(2,5)
CH2(4)
CH3
CH2(3,4)
CH2(3,4)
CH2
CH2(3,5)
CH3CO
CH2
methane
silicone grease
acetonitrile
hexamethyldisiloxane
ethane
ethyl methyl ketone
triethylamine
n-pentane
n-hexane
ethyl acetate
diethyl ether
propane
propane
hexamethylbenzene
ethanol
propylene
acetic acid
allyl acetate
ethyl acetate
BHT
toluene
dimethylacetamide
n-pentane
n-hexane
cyclohexanone
2-propanol
pyrrolidine
tetrahydrofuran
cyclohexane
cyclohexanone
ethyl methyl ketone
H grease8
29.84
30.32
30.33
30.92
31.25
31.45
31.64
34.16
34.25
34.72
35.28
36.50
36.87 (d)
36.89
38.13
40.76
41.11
41.97
43.50
46.25
46.93
50.41
52.57
53.52
54.89
55.70
58.28
59.01
59.08
60.49
62.50
63.79
CH2
(CH3)3C
(CH3)3C
CH3
(CH3)3C
CH3
CH2(3,4)
CH2(3)
(CH3)3C
(CH3)3C
NCH3
CH3
CH3
CH2CH3
NCH3
CH3
CH2
CH2(2,6)
CH2
CH2
CH2(2,5)
CH3
CH3
CH2
CH3
CH3O
CH2
CH3
CH3
CH2
CH3
CH2
pump oil
BHA
BHT
acetone
tert-butyl alcohol
dimethyl malonate
n-hexane
n-pentane
BHT
BHA
dimethylacetamide
dimethyl malonate
HMPAi
ethyl methyl ketone
dimethylacetamide
dimethyl sulfoxide
dimethyl malonate
cyclohexanone
1,2-dichloroethane
triethylamine
pyrrolidine
methanol
dimethyl malonate
dichloromethane
dimethyl carbonate
BHA
ethanol
diglyme
1,2-dimethoxyethane
ethyl acetate
nitromethane
ethylene glycol
64.50
65.28
65.91
67.14
67.97
68.55
69.15
70.51
70.55
71.84
71.90
77.16 (t)
77.36
96.34
107.98
109.57
110.69
115.74
116.43
117.77
118.34
118.96
122.00
123.13
123.75
124.99
125.33
125.55
128.26
128.27
128.37
129.07
CH
CH2
CH2
CH2
CH2(2,5)
CH2
(CH3)3C
CH2
CH2
CH2
CH2
CDCl3
CH
CCl4
CH(3,4)
CH(3,4)
CH(3,5)
CH2
CN
CH(2,5)
CHCH2
CHCH2
CH(4,5)
CH2
CH(3,5)
CO2
CH(4)
CH(3,5)
CH(3,5)
C(4)
CH
CH(2,6)
2-propanol
allyl acetate
diethyl ether
1,4-dioxane
tetrahydrofuran
diallyl carbonate
tert-butyl alcohol
diglyme
18-crown-6
1,2-dimethoxyethane
diglyme
CDCl3 signal
chloroform
carbon tetrachloride
pyrrole
furan
BHA
propylene
acetonitrile
pyrrole
allyl acetate
diallyl carbonate
imidazole
ethylene
pyridine
carbon dioxide
toluene
BHT
toluene
BHT
benzene
toluene
129.16
129.91
131.58
132.21
132.33
133.91
134.64
135.38
135.87
135.96
136.58
137.36
137.89
142.71
147.85
149.90
151.55
152.57
154.88
156.45
162.62
167.18
170.81
171.07
171.36
175.99
192.67
192.83
207.07
209.56
212.57
CH(3,5)
CH(2,6)
CHCH2
C
CHCH2
CH
CH (4)
CH(2)
C(2,6)
CH(4)
C(1)
C(4)
C(1)
CH(2,5)
C(2,6)
CH(2,6)
C(1)
C(1)
CO
CO
CH
CO2
CO
CO
CO
CO
HCO
CS2
CO
CO
CO
benzaldehyde
benzaldehyde
diallyl carbonate
hexamethylbenzene
allyl acetate
propylene
benzaldehyde
imidazole
BHT
pyridine
benzaldehyde
BHA
toluene
furan
BHA
pyridine
BHT
BHA
diallyl carbonate
dimethyl carbonate
dimethylformamide
dimethyl malonate
allyl acetate
dimethylacetamide
ethyl acetate
acetic acid
benzaldehyde
carbon disulfide
acetone
ethyl methyl ketone
cyclohexanone
S9
mult
0.10
0.17
0.26
0.43
0.58
0.69
0.81
0.83
0.84
0.87
0.88
0.880.96
0.89
0.890.96
0.94
0.95
0.95
0.97
1.03
1.10
1.161.20
1.22
1.25
1.30
1.32
1.33
1.331.39
1.34
1.36
1.36
1.40
1.43
1.55
1.57
1.57
1.59
1.59
1.63
proton
s
CH3
s
CH4
s
CH3
s
OH
s
OH
s
CH3
s
CH3
s6
OH
t, 7
CH2CH3
t, 7
CH3
t, 7
CH3
m
CH3
t, 7.3
CH3
m
CH3
t, 7
CH2CH3
d, 6
CH3
t, 7
CH3
t, 7
CH3
s
CH3
t, 7
CH3
m
CH2(4)
m
CH2
m
CH2
br s
CH2
sept, 7.3
CH2
br s
CH2
m
CH2(3,5)
s
ArC(CH3)3
s
ArC(CH3)3
m
CH2(3,4)
s
CH2
m
CH2(3,4)
dt, 6.4, 1.5
CH3
s
CH3
s
CH3
s
CH3CO
s
CH3CO
s
CH3
impurity
shift
mult
proton
impurity
shift
mult
proton
impurity
hexamethyldisiloxane
methane
silicone grease
water
tert-butyl alcohol
acetonitrile
ethane
ethanol
ethyl methyl ketone
n-pentane
n-hexane
pump oil
propane
H grease8
ethyl acetate
2-propanol
triethylamine
ethanol
tert-butyl alcohol
diethyl ether
cyclohexanone
n-hexane
n-pentane
pump oil
propane
H grease8
cyclohexanone
BHA
BHT
pyrrolidine
cyclohexane
tetrahydrofuran
propylene
acetic acid
acetone
dimethylacetamide
ethyl methyl ketone
allyl acetate
1.64
1.69
1.82
1.95
1.96
2.08
2.10
2.11
2.11
2.23
2.37
2.39
2.42
2.54
2.56
2.91
2.92
3.01
3.03
3.12
3.12
3.24
3.25
3.31
3.31
3.31
3.33
3.36
3.36
3.36
3.43
3.48
3.54
3.65
3.87
4.32
4.34
4.34
s
s
q, 7
t
s
p
s
s
s
s
s
q, 7
d, 9.5
m
s
s
s
s
s9
s
s
s
q, 7
m
s
s
s
s
q, 76
s
m
s
m
sept, 6
q, 7
s
ddd
ddd
CH3
CH3CO
CH2CH3
CH2(2,6)
CH3
CH3
CH3
NCH3
CH3
ArCH3
CH3
CH2
CH3
CH2(2,5)
NCH3
CH2
CH2
CH3
CH3
OCH3
CH3
CH3
CH2
CH2
CH2
CH3
CH2
CH2
CH2
CH2
CH2
ArOCH3
CH2(2,5)
CH
CH2CH3
CH2
CH2
CH2
dimethyl sulfoxide
ethyl acetate
ethyl methyl ketone
cyclohexanone
dimethylformamide
Toluene-d8 residual
hexamethylbenzene
dimethylacetamide
toluene
BHT
dimethylformamide
triethylamine
HMPA
pyrrolidine
dimethylacetamide
1,2-dichloroethane
dimethyl malonate
nitromethane
methanol
diglyme
1,2-dimethoxyethane
dimethyl malonate
diethyl ether
diglyme
1,2-dimethoxyethane
dimethyl carbonate
1,4-dioxane
18-crown-6
ethanol
ethylene glycol
diglyme
BHA
tetrahydrofuran
2-propanol
ethyl acetate
dichloromethane
allyl acetate
diallyl carbonate
4.45
4.50
4.72
4.92
4.92
4.94
4.98
5.05
5.09
5.25
5.63
5.674
5.70
6.07
6.10
6.27
6.43
6.67
6.83
6.86
6.956.99
6.967.01
6.97
6.99
6.99
7.01
7.037.07
7.09
7.09
7.10
7.12
7.30
7.457.47
7.57
7.71
8.47
9.57
s
s
s
ddt
dm, 10
ddt
dm, 17
ddt
ddt
s
ddt
t(nfo ABX)
m
dd
s
m
m
m
s
s
m
m
p
s
m
s
m
m
m
dd
s
s
m
s
br t
m
s
OH5
H2
OH5
CHCH2(2)
CH2(1)
CHCH2(2)
CH2(2)
CHCH2(1)
CHCH2(1)
CH2
CHCH2
CHCH2
CH
CH(3,4)
CH
CH(3,4)
CH(2,5)
CH(3,5)
ArH
CH(4,5)
CH(3,5)
CH(2,4,6)
CH(4)
ArH
CH(4)
CH(2,6)
CH(4)
CH(3,5)
CH(3,5)
CH(2,5)
CH
CH(2)
CH(2,6)
CH
NH
CH(2,6)
HCO
BHA
hydrogen
BHT
diallyl carbonate
propylene
allyl acetate
propylene
allyl acetate
diallyl carbonate
ethylene
diallyl carbonate
allyl acetate
propylene
furan
chloroform
pyrrole
pyrrole
pyridine
BHA
imidazole
benzaldehyde
toluene
Toluene-d8 residual
BHT
pyridine
Toluene-d8 residual
benzaldehyde
Toluene-d8 residual
toluene
furan
benzene
imidazole
benzaldehyde
dimethylformamide
pyrrole
pyridine
benzaldehyde
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
4.34
0.03
1.37
1.99
6.94
7.89
12.39
14.23
14.27
14.34
15.47
16.63
16.65
16.84
18.78
19.32
20.21
20.27
20.43 (sept)
20.46
21.05
21.37
21.42
22.79
23.12
25.15
25.24
25.75
25.79
27.05
27.31
28.74
30.03
CH4
CH3
CH3
CH3
CH3
CH2CH3
CH3
CH3
CH3
CH3
CH3
CH2
CH3
CH3
CH3
CH3
CH3
CH3
CD3
CH3CO
CH3
CH3
CH3Ar
CH2(2,4)
CH2(2,5)
CH2(4)
CH3
CH2(3,4)
CH2(3,4)
CH2(3,5)
CH2
CH3CO
CH3
methane
acetonitrile
silicone grease
hexamethyldisiloxane
ethane
ethyl methyl ketone
triethylamine
ethyl acetate
n-pentane
n-hexane
diethyl ether
propane
propane
hexamethylbenzene
ethanol
propylene
allyl acetate
acetic acid
toluene-d8 signal
ethyl acetate
dimethylacetamide
toluene
BHT
n-pentane
n-hexane
cyclohexanone
2-propanol
pyrrolidine
tetrahydrofuran
cyclohexanone
cyclohexane
ethyl methyl ketone
acetone
30.30
30.31
30.33
30.49
30.64
31.39
32.06
34.39
34.54
34.58
34.69
35.22
36.32
36.8 (d)
36.98
40.41
40.88
41.78
43.40
46.82
47.12
49.90
51.76
53.47
54.13
55.04
57.81
58.62
58.63
60.08
61.14
64.12
64.29
(CH3)3C
CH2
CH2
(CH3)3C
CH3
(CH3)3C
CH2(3,4)
(CH3)3C
CH2(3)
NCH3
(CH3)3C
CH3
CH2CH3
CH3
NCH3
CH3
CH2
CH2(2,6)
CH2
CH2
CH2(2,5)
CH3
CH3
CH2
CH3
CH3O
CH2
CH3
CH3
CH2
CH3
CH
CH2
BHA
H grease8
pump oil
tert-butyl alcohol
dimethylformamide
BHT
n-hexane
BHT
n-pentane
dimethylacetamide
BHA
dimethylformamide
ethyl methyl ketone
HMPA11
dimethylacetamide
dimethyl sulfoxide
dimethyl malonate
cyclohexanone
1,2-dichloroethane
triethylamine
pyrrolidine
methanol
dimethyl malonate
dichloromethane
dimethyl carbonate
BHA
ethanol
diglyme
1,2-dimethoxyethane
ethyl acetate
nitromethane
2-propanol
ethylene glycol
64.87
65.94
67.17
67.75
68.12
68.20
70.86
70.92
72.25
72.39
77.89
96.57
108.15
109.63
110.99
115.76
115.89
117.49
117.61
118.04
122.13
122.92
123.46
124.86
125.13 (t)
125.66
125.79
127.96 (t)
128.44
128.51
128.57
128.68
128.87 (t)
CH2
CH2
CH2
CH2(2,5)
(CH3)3C
CH2
CH2
CH2
CH2
CH2
CH
CCl4
CH(3,4)
CH(3,4)
CH(3,5)
CN
CH2
CHCH2
CH(2,5)
CHCH2
CH(4,5)
CH2
CH(3,5)
CO2
CD(4)
CH(4)
CH(3,5)
CD(3,5)
C(4)
CH(3,5)
CH
CH(3,5)
CD(2,6)
allyl acetate
diethyl ether
1,4-dioxane
tetrahydrofuran
tert-butyl alcohol
diallyl carbonate
18-crown-6
diglyme
1,2-dimethoxyethane
diglyme
chloroform
carbon tetrachloride
pyrrole
furan
BHA
acetonitrile
propylene
allyl acetate
pyrrole
diallyl carbonate
imidazole
ethylene
pyridine
carbon dioxide
toluene-d8 signal
toluene
BHT
toluene-d8 signal
BHT
toluene
benzene
benzaldehyde
toluene-d8 signal
129.33
129.61
131.72
132.30
132.98
133.61
133.88
135.17
135.57
136.12
137.12
137.34
137.48
137.84
142.65
148.06
150.25
152.06
153.50
155.15
156.61
161.93
166.49
169.44
169.65
170.02
175.30
191.09
192.71
204.00
206.31
208.60
CH(2,6)
CH(2,6)
C
CHCH2
CHCH2
CH
CH (4)
CH(4)
CH(2)
C(2,6)
C(1)
C(4)
C
C(1)
CH(2,5)
C(2,6)
CH(2,6)
C(1)
C(1)
CO
CO
CH
CO2
CO
CO
CO
CO
HCO
CS2
CO
CO
CO
toluene
benzaldehyde
hexamethylbenzene
diallyl carbonate
allyl acetate
propylene
benzaldehyde
pyridine
imidazole
BHT
benzaldehyde
BHA
toluene-d8 signal
toluene
furan
BHA
pyridine
BHT
BHA
diallyl carbonate
dimethyl carbonate
dimethylformamide
dimethyl malonate
allyl acetate
dimethylacetamide
ethyl acetate
acetic acid
benzaldehyde
carbon disulfide
acetone
ethyl methyl ketone
cyclohexanone
S10
mult
0.12
0.16
0.29
0.40
0.50
0.58
0.63
0.80
0.85
0.86
0.87
0.89
0.900.98
0.910.97
0.92
0.95
0.96
0.96
1.05
1.081.16
1.11
1.23
1.24
1.26
1.281.37
1.32
1.33
1.37
1.38
1.40
1.40
1.41
1.52
1.55
1.55
1.58
1.60
proton
s
CH3
s
CH4
s
CH3
s
OH
6
s
OH
s
CH3
s
OH
s
CH3
t, 7
CH2CH3
t, 7.3
CH3
t, 7
CH3
t, 7
CH3
m
CH3
m
CH3
t, 7
CH2CH3
d, 6
CH3
t, 7
CH3
t, 7
CH3
s
CH3
m
CH2(4)
t, 7
CH3
m
CH2
m
CH2
sept, 7.3
CH2
m
CH2(3,5)
br s
CH2
m
CH2(3,4)
br s
CH2
s
ArC(CH3)3
s
CH2
m
CH2(3,4)
s
ArC(CH3)3
s
CH3
s
CH3
dt, 6.4, 1.5
CH3
s
CH3CO
s
CH3CO
impurity
shift
mult
proton
impurity
shift
mult
proton
impurity
hexamethyldisiloxane
methane
silicone grease
water
ethanol
acetonitrile
tert-butyl alcohol
ethane
ethyl methyl ketone
propane
n-pentane
n-hexane
H grease8
pump oil
ethyl acetate
2-propanol
ethanol
triethylamine
tert-butyl alcohol
cyclohexanone
diethyl ether
n-pentane
n-hexane
propane
cyclohexanone
H grease8
pyrrolidine
pump oil
BHT
cyclohexane
tetrahydrofuran
BHA
acetic acid
acetone
propylene
ethyl methyl ketone
dimethylacetamide
1.63
1.65
1.68
1.81
1.86
1.98
2.05
2.11
2.13
2.24
2.36
2.40
2.40
2.54
2.57
2.90
2.94
2.97
3.07
3.11
3.12
3.23
3.26
3.30
3.33
3.34
3.34
3.35
3.39
3.41
3.46
3.48
3.57
3.67
3.89
4.27
4.38
s
s
s
q, 7
s
t
s
s
s
s
s
d, 9.5
q, 7
m
s
s
s
s
s9
s
s
s
q, 7
s
s
m
q, 76
s
s
s
m
s
m
sept, 6
q, 7
s
ddd
CH3
CH3CO
CH3
CH2CH3
CH3
CH2(2,6)
NCH3
CH3
CH3
ArCH3
CH3
CH3
CH2
CH2(2,5)
NCH3
CH2
CH3
CH2
CH3
OCH3
CH3
CH3
CH2
CH3
CH2
CH2
CH2
CH2
CH2
CH2
CH2
ArOCH3
CH2(2,5)
CH
CH2CH3
CH2
CH2
allyl acetate
ethyl acetate
dimethyl sulfoxide
ethyl methyl ketone
dimethylformamide
cyclohexanone
dimethylacetamide
toluene
hexamethylbenzene
BHT
dimethylformamide
HMPA
triethylamine
pyrrolidine
dimethylacetamide
1,2-dichloroethane
nitromethane
dimethyl malonate
methanol
diglyme
1,2-dimethoxyethane
dimethyl malonate
diethyl ether
dimethyl carbonate
1,2-dimethoxyethane
diglyme
ethanol
1,4-dioxane
18-crown-6
ethylene glycol
diglyme
BHA
tetrahydrofuran
2-propanol
ethyl acetate
dichloromethane
allyl acetate
4.38
4.47
4.53
4.79
4.92
4.94
4.95
5.01
5.06
5.09
5.25
5.65
5.684
5.72
6.08
6.15
6.37
6.48
6.66
6.90
6.93
6.936.99
6.98
7.017.07
7.02
7.05
7.13
7.13
7.15
7.16
7.33
7.497.53
7.63
7.80
8.53
9.64
ddd
s
s
s
ddt
ddt
dm, 10
dm, 17
ddt
ddt
s
ddt
t(nfo ABX)
m
dd
s
m
m
m
s
s
m
m
m
m
s
dd
m
s
s
s
m
s
br t
m
s
CH2
H2
OH5
OH5
CHCH2(2)
CHCH2(2)
CH2(1)
CH2(2)
CHCH2(1)
CHCH2(1)
CH2
CHCH2
CHCH2
CH
CH(3,4)
CH
CH(3,4)
CH(2,5)
CH(3,5)
CH(4,5)
ArH
CH(3,5)
CH(4)
CH(4)
CH(2,4,6)
ArH
CH(2,5)
CH(3,5)
CH
CH
CH(2)
CH(2,6)
CH
NH
CH(2,6)
HCO
diallyl carbonate
hydrogen
BHA
BHT
diallyl carbonate
allyl acetate
propylene
propylene
allyl acetate
diallyl carbonate
ethylene
diallyl carbonate
allyl acetate
propylene
furan
chloroform
pyrrole
pyrrole
pyridine
imidazole
BHA
benzaldehyde
pyridine
benzaldehyde
toluene
BHT
furan
toluene
benzene
C6D6 residual
imidazole
benzaldehyde
dimethylformamide
pyrrole
pyridine
benzaldehyde
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
4.29
0.20
1.38
2.05
6.96
7.91
12.35
14.19
14.25
14.32
15.46
16.60
16.66
16.95
18.72
19.38
20.37
20.37
20.56
21.10
21.16
21.40
22.72
23.04
25.03
25.18
25.65
25.72
27.00
27.23
28.56
30.14
CH4
CH3
CH3
CH3
CH3
CH2CH3
CH3
CH3
CH3
CH3
CH3
CH2
CH3
CH3
CH3
CH3
CH3
CH3
CH3CO
CH3
CH3
CH3Ar
CH2(2,4)
CH2(2,5)
CH2(4)
CH3
CH2(3,4)
CH2(3,4)
CH2(3,5)
CH2
CH3CO
CH3
methane
acetonitrile
silicone grease
hexamethyldisiloxane
ethane
ethyl methyl ketone
triethylamine
ethyl acetate
n-pentane
n-hexane
diethyl ether
propane
propane
hexamethylbenzene
ethanol
propylene
acetic acid
allyl acetate
ethyl acetate
toluene
dimethylacetamide
BHT
n-pentane
n-hexane
cyclohexanone
2-propanol
pyrrolidine
tetrahydrofuran
cyclohexanone
cyclohexane
ethyl methyl ketone
acetone
30.22
30.24
30.35
30.47
30.72
31.34
31.96
34.35
34.45
34.67
34.72
35.25
36.36
36.88 (d)
37.03
40.03
41.04
41.83
43.59
46.77
46.86
49.97
51.86
53.46
54.30
55.27
57.86
58.66
58.68
60.21
61.16
64.23
CH2
CH2
(CH3)3C
(CH3)3C
CH3
(CH3)3C
CH2(3,4)
(CH3)3C
CH2(3)
NCH3
(CH3)3C
CH3
CH2CH3
CH3
NCH3
CH3
CH2
CH2(2,6)
CH2
CH2
CH2(2,5)
CH3
CH3
CH2
CH3
CH3O
CH2
CH3
CH3
CH2
CH3
CH
H grease8
pump oil
BHA
tert-butyl alcohol
dimethylformamide
BHT
n-hexane
BHT
n-pentane
dimethylacetamide
BHA
dimethylformamide
ethyl methyl ketone
HMPA11
dimethylacetamide
dimethyl sulfoxide
dimethyl malonate
cyclohexanone
1,2-dichloroethane
triethylamine
pyrrolidine
methanol
dimethyl malonate
dichloromethane
dimethyl carbonate
BHA
ethanol
diglyme
1,2-dimethoxyethane
ethyl acetate
nitromethane
2-propanol
64.34
64.92
65.94
67.16
67.80
68.19
68.28
70.59
70.87
72.21
72.35
77.79
96.44
108.21
109.67
111.15
115.92
116.02
117.64
117.78
118.22
122.16
122.96
123.58
124.76
125.68
125.83
128.06 (t)
128.52
128.56
128.62
128.95
CH2
CH2
CH2
CH2
CH2(2,5)
(CH3)3C
CH2
CH2
CH2
CH2
CH2
CH
CCl4
CH(3,4)
CH(3,4)
CH(3,5)
CH2
CN
CHCH2
CH(2,5)
CHCH2
CH(4,5)
CH2
CH(3,5)
CO2
CH(4)
CH(3,5)
CD
C(4)
CH(3,5)
CH
CH(3,5)
ethylene glycol
allyl acetate
diethyl ether
1,4-dioxane
tetrahydrofuran
tert-butyl alcohol
diallyl carbonate
18-crown-6
diglyme
1,2-dimethoxyethane
diglyme
chloroform
carbon tetrachloride
pyrrole
furan
BHA
propylene
acetonitrile
allyl acetate
pyrrole
diallyl carbonate
imidazole
ethylene
pyridine
carbon dioxide
toluene
BHT
C6D6 signal
BHT
toluene
benzene
benzaldehyde
129.33
129.65
131.79
132.18
132.90
133.69
133.95
135.28
135.76
136.08
137.05
137.50
137.91
142.73
148.13
150.27
152.05
153.62
155.24
156.71
162.13
166.66
169.67
169.95
170.44
175.82
191.43
192.69
204.43
206.55
209.10
CH(2,6)
CH(2,6)
C
CHCH2
CHCH2
CH
CH (4)
CH(4)
CH(2)
C(2,6)
C(1)
C(4)
C(1)
CH(2,5)
C(2,6)
CH(2,6)
C(1)
C(1)
CO
CO
CH
CO2
CO
CO
CO
CO
HCO
CS2
CO
CO
CO
toluene
benzaldehyde
hexamethylbenzene
diallyl carbonate
allyl acetate
propylene
benzaldehyde
pyridine
imidazole
BHT
benzaldehyde
BHA
toluene
furan
BHA
pyridine
BHT
BHA
diallyl carbonate
dimethyl carbonate
dimethylformamide
dimethyl malonate
allyl acetate
dimethylacetamide
ethyl acetate
acetic acid
benzaldehyde
carbon disulfide
acetone
ethyl methyl ketone
cyclohexanone
S11
mult
0.10
0.14
0.15
0.79
0.84
0.84
0.85
0.860.92
0.880.91
0.89
0.93
1.03
1.04
1.04
1.06
1.10
1.12
1.19
1.21
1.23
1.26
1.30
1.30
1.30
1.31
1.331.37
1.37
1.37
1.37
1.39
1.43
1.481.53
1.55
1.58
1.74
1.76
1.77
1.78
proton
s
CH3
s
CH3
s
CH4
s
CH3
t, 7
CH3
t, 7.3
CH3
t, 7
CH3
m
CH3
m
CH3
t, 7
CH2CH3
t, 7
CH3
s
OH
t, 7
CH2CH3
d, 6
CH3
t, 7
CH3
t, 7
CH3
s
CH3
m
CH2
s
CH3
m
CH2
sept, 7.3
CH2
s
OH
br s
CH2
9
s
OH
br s
CH2
m
CH2(4)
s
ArC(CH3)3
s
ArC(CH3)3
s
CH2
6
s
OH
m
CH2(3,4)
m
CH2(3,5)
m
CH2(3,4)
dt, 6.4, 1.5
CH3
s
CH3CO
s
CH3
s
CH3
s
CH3CO
impurity
shift
mult
proton
impurity
shift
mult
proton
impurity
hexamethyldisiloxane
silicone grease
methane
ethane
n-pentane
propane
n-hexane
H grease8
pump oil
ethyl methyl ketone
triethylamine
water
ethyl acetate
2-propanol
ethanol
diethyl ether
tert-butyl alcohol
n-hexane
acetonitrile
n-pentane
propane
tert-butyl alcohol
H grease8
methanol
pump oil
cyclohexanone
BHA
BHT
cyclohexane
ethanol
pyrrolidine
cyclohexanone
tetrahydrofuran
propylene
dimethylacetamide
acetic acid
acetone
ethyl acetate
1.78
1.80
2.03
2.06
2.08
2.10
2.16
2.20
2.30
2.39
2.42
2.47
2.51
2.64
2.65
3.15
3.16
3.17
3.25
3.26
3.31
3.37
3.37
3.41
3.41
3.45
3.48
3.49
3.51
3.58
3.59
3.59
3.61
3.82
3.96
4.44
4.46
4.49
s
s
s
q, 7
t
s
s
s
s
q, 7
s
d, 9.5
s
m
s
s
s
s
s9
s
q, 7
m
s
s
s
s
s
m
q, 76
s
s
m
s
sept, 6
q, 7
ddd
ddd
s
CH3CO
CH3
CH3
CH2CH3
CH2(2,6)
CH3
CH3
ArCH3
CH3
CH2
NCH3
CH3
CH3
CH2(2,5)
NCH3
CH2
OCH3
CH3
CH3
CH2
CH2
CH2
CH2
CH2
CH3
CH2
CH3
CH2
CH2
CH2
CH3
CH2(2,5)
ArOCH3
CH
CH2CH3
CH2
CH2
H2
4.62
4.77
4.91
4.98
5.03
5.04
5.15
5.17
5.29
5.50
5.72
5.75
5.77
6.19
6.27
6.62
6.74
6.83
6.90
6.96
6.97
6.99
7.01
7.017.08
7.107.17
7.14
7.157.19
7.20
7.24
7.247.28
7.25
7.53
7.597.61
7.73
8.51
8.61
9.77
s
s
dm, 10
dm, 17
ddt
ddt
ddt
ddt
s
s
m
ddt
ddt
dd
m
m
s
s
m
br. s
s
br. s
s
m
m
br. s
m
s
dd
m
m
s
m
s
m
br t
s
OH5
CH2
CH2(1)
CH2(2)
CHCH2(2)
CHCH2(2)
CHCH2(1)
CHCH2(1)
CH2
OH5
CH
CHCH2
CHCH2
CH(3,4)
CH(3,4)
CH(2,5)
CH
ArH
CH(3,5)
CH(4)
ArH
CH(3,5)
CH(4,5)
CH(2,4,6)
CH(3,5)
CH(2,6)
CH(3,5)
CH
CH(2,5)
CH(4)
CH(4)
CH(2)
CH(2,6)
CH
CH(2,6)
NH
HCO
BHA
dichloromethane
propylene
propylene
diallyl carbonate
allyl acetate
allyl acetate
diallyl carbonate
ethylene
BHT
propylene
diallyl carbonate
allyl acetate
furan
pyrrole
pyrrole
chloroform
BHA
pyridine
C6D5Cl residual
BHT
C6D5Cl residual
imidazole
toluene
toluene
C6D5Cl residual
benzaldehyde
benzene
furan
benzaldehyde
pyridine
imidazole
benzaldehyde
dimethylformamide
pyridine
pyrrole
benzaldehyde
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
4.33
0.63
1.09
1.92
6.91
7.79
11.87
14.07
14.10
14.18
15.35
16.48
16.56
16.68
18.55
19.32
20.40
20.40
20.50
21.03
21.10
21.23
22.54
22.86
25.07
25.14
25.59
25.68
26.99
27.02
28.82
30.11
30.11
CH4
CH3
CH3
CH3
CH3
CH2CH3
CH3
CH3
CH3
CH3
CH3
CH2
CH3
CH3
CH3
CH3
CH3
CH3
CH3CO
CH3
CH3Ar
CH3
CH2(2,4)
CH2(2,5)
CH2(4)
CH3
CH2(3,4)
CH2(3,4)
CH2
CH2(3,5)
CH3CO
CH2
CH2
methane
acetonitrile
silicone grease
hexamethyldisiloxane
ethane
ethyl methyl ketone
triethylamine
ethyl acetate
n-pentane
n-hexane
diethyl ether
propane
propane
hexamethylbenzene
ethanol
propylene
acetic acid
allyl acetate
ethyl acetate
dimethylacetamide
BHT
toluene
n-pentane
n-hexane
cyclohexanone
2-propanol
pyrrolidine
tetrahydrofuran
cyclohexane
cyclohexanone
ethyl methyl ketone
H grease8
pump oil
30.12
30.19
30.21
30.71
31.13
31.77
34.11
34.26
34.56
34.59
35.45
36.39
36.64 (d)
37.13
40.27
40.93
41.79
43.60
46.36
46.75
49.66
51.89
53.54
54.23
55.08
57.63
58.31
58.42
60.06
61.68
64.03
64.18
64.86
CH3
(CH3)3C
(CH3)3C
CH3
(CH3)3C
CH2(3,4)
(CH3)3C
CH2(3)
(CH3)3C
NCH3
CH3
CH2CH3
CH3
NCH3
CH3
CH2
CH2(2,6)
CH2
CH2
CH2(2,5)
CH3
CH3
CH2
CH3
CH3O
CH2
CH3
CH3
CH2
CH3
CH2
CH
CH2
acetone
BHT
BHA
dimethylformamide
tert-butyl alcohol
n-hexane
BHT
n-pentane
BHA
dimethylacetamide
dimethylformamide
ethyl methyl ketone
HMPA11
dimethylacetamide
dimethyl sulfoxide
dimethyl malonate
cyclohexanone
1,2-dichloroethane
triethylamine
pyrrolidine
methanol
dimethyl malonate
dichloromethane
dimethyl carbonate
BHA
ethanol
1,2-dimethoxyethane
diglyme
ethyl acetate
nitromethane
ethylene glycol
2-propanol
allyl acetate
65.79
66.95
67.64
68.19
68.19
70.55
70.56
71.81
72.07
77.67
96.38
108.03
109.64
110.84
115.86
115.93
117.63
117.65
118.22
121.96
122.95
123.49
125.43
125.58
125.96 (t)
126.08
128.25 (t)
128.26
128.31
128.38
128.87
129.12
CH2
CH2
CH2(2,5)
(CH3)3C
CH2
CH2
CH2
CH2
CH2
CH
CCl4
CH(3,4)
CH(3,4)
CH(3,5)
CH2
CN
CHCH2
CH(2,5)
CHCH2
CH(4,5)
CH2
CH(3,5)
CH(4)
CH(3,5)
CD(4)
CO2
CD(3,5)
C(4)
CH(3,5)
CH
CH(3,5)
CH(2,6)
diethyl ether
1,4-dioxane
tetrahydrofuran
tert-butyl alcohol
diallyl carbonate
18-crown-6
diglyme
1,2-dimethoxyethane
diglyme
chloroform
carbon tetrachloride
pyrrole
furan
BHA
propylene
acetonitrile
allyl acetate
pyrrole
diallyl carbonate
imidazole
ethylene
pyridine
toluene
BHT
C6D5Cl signal
carbon dioxide
C6D5Cl signal
BHT
toluene
benzene
benzaldehyde
toluene
129.26 (t)
129.49
131.54
131.93
132.69
133.57
134.02
134.19
135.32
135.50
135.92
136.78
137.29
137.65
142.49
147.87
149.93
151.69
153.19
154.87
156.36
162.01
166.51
169.59
169.79
170.20
175.67
191.24
192.49
204.83
206.87
209.30
CD(2,6)
CH(2,6)
C
CHCH2
CHCH2
CH
CH (4)
CCl
CH(4)
CH(2)
C(2,6)
C(1)
C(4)
C(1)
CH(2,5)
C(2,6)
CH(2,6)
C(1)
C(1)
CO
CO
CH
CO2
CO
CO
CO
CO
HCO
CS2
CO
CO
CO
C6D5Cl signal
benzaldehyde
hexamethylbenzene
diallyl carbonate
allyl acetate
propylene
benzaldehyde
C6D5Cl signal
pyridine
imidazole
BHT
benzaldehyde
BHA
toluene
furan
BHA
pyridine
BHT
BHA
diallyl carbonate
dimethyl carbonate
dimethylformamide
dimethyl malonate
allyl acetate
dimethylacetamide
ethyl acetate
acetic acid
benzaldehyde
carbon disulfide
acetone
ethyl methyl ketone
cyclohexanone
S12
mult
0.07
0.13
0.17
0.83
0.87
0.88
0.88
0.88
0.90
0.96
0.96
1.10
1.11
1.12
1.18
1.20
1.27
1.28
1.29
1.29
1.31
1.41
1.41
1.43
1.68
1.701.74
1.79
1.791.83
1.96
1.97
1.97
2.02
2.05
2.05
2.07
2.09
proton
s
CH3
s
CH3
s
CH4
s
CH3
m
CH3
t, 7
CH3
t, 7
CH3
t, 7.3
CH3
m
CH3
t, 7
CH2CH3
t, 7
CH3
d, 6
CH3
t, 7
CH3
t, 7
CH3
s
CH3
t, 7
CH2CH3
m
CH2
m
CH2
br s
CH2
br s
CH2
sept, 7.3
CH2
s
ArC(CH3)3
s
ArC(CH3)3
s
CH2
dt, 6.4, 1.5
CH3
m
CH2(4)
m
CH2(3,4)
m
CH2(3,5)
s
CH3
s
CH3CO
s
CH3CO
s
CH3
s
CH3
p
CHD2
s
CH3CO
s
CH3
impurity
shift
mult
proton
impurity
shift
mult
proton
impurity
hexamethyldisiloxane
silicone grease
methane
ethane
pump oil
n-hexane
n-pentane
propane
H grease8
ethyl methyl ketone
triethylamine
2-propanol
diethyl ether
ethanol
tert-butyl alcohol
ethyl acetate
n-pentane
n-hexane
H grease8
pump oil
propane
BHA
BHT
cyclohexane
propylene
cyclohexanone
tetrahydrofuran
cyclohexanone
acetic acid
dimethylacetamide
ethyl acetate
allyl acetate
acetonitrile
(CD3)2CO residual
ethyl methyl ketone
acetone
2.17
2.22
2.27
2.32
2.45
2.45
2.52
2.59
2.78
2.83
2.843
2.94
3.00
3.12
3.28
3.28
3.28
3.31
3.39
3.41
3.42
3.46
3.47
3.56
3.57
3.59
3.59
3.63
3.68
3.72
3.72
3.87
3.90
4.05
4.43
4.53
s
s
t
s
q, 7
q, 7
s
d, 9.5
s
s
s
s
s
s9
s
s
s
s9
s6
q, 7
s
s
m
m
q, 76
s
s
m
s
s
s
s
sept, 6
q, 7
s
ddd
CH3
ArCH3
CH2(2,6)
CH3
CH2CH3
CH2
CH3
CH3
CH3
NCH3
OH
CH3
NCH3
OH
OCH3
CH3
CH2
CH3
OH
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH2(2,5)
CH3
ArOCH3
CH3
CH2
CH
CH2CH3
CH3
CH2
hexamethylbenzene
BHT
cyclohexanone
toluene
ethyl methyl ketone
triethylamine
dimethyl sulfoxide
HMPA
dimethylformamide
dimethylacetamide
water
dimethylformamide
dimethylacetamide
methanol
diglyme
1,2-dimethoxyethane
ethylene glycol
methanol
ethanol
diethyl ether
dimethyl malonate
1,2-dimethoxyethane
diglyme
diglyme
ethanol
18-crown-6
1,4-dioxane
tetrahydrofuran
dimethyl malonate
BHA
dimethyl carbonate
1,2-dichloroethane
2-propanol
ethyl acetate
nitromethane
allyl acetate
4.54
4.62
4.90
5.00
5.18
5.23
5.29
5.35
5.38
5.63
5.65
5.81
5.92
5.96
6.07
6.43
6.72
6.77
6.96
7.04
7.107.20
7.107.20
7.35
7.36
7.56
7.597.63
7.62
7.697.73
7.76
7.927.94
7.96
8.02
8.58
10.02
10.05
s
ddd
dm, 10
dm, 17
ddt
ddt
ddt
ddt
s
s
s
m
ddt
ddt
m
dd
s
m
s
s
m
m
m
s
dd
m
s
m
m
m
s
s
m
br t
s
H2
CH2
CH2(1)
CH2(2)
CHCH2(2)
CHCH2(2)
CHCH2(1)
CHCH2(1)
CH2
CH2
OH5
CH
CHCH2
CHCH2
CH(3,4)
CH(3,4)
ArH
CH(2,5)
ArH
CH(4,5)
CH(2,4,6)
CH(3,5)
CH(3,5)
CH
CH(2,5)
CH(3,5)
CH(2)
CH(4)
CH(4)
CH(2,6)
CH
CH
CH(2,6)
NH
HCO
hydrogen
diallyl carbonate
propylene
propylene
allyl acetate
diallyl carbonate
allyl acetate
diallyl carbonate
ethylene
dichloromethane
BHA
propylene
allyl acetate
diallyl carbonate
pyrrole
furan
BHA
pyrrole
BHT
imidazole
toluene
toluene
pyridine
benzene
furan
benzaldehyde
imidazole
benzaldehyde
pyridine
benzaldehyde
dimethylformamide
chloroform
pyridine
pyrrole
benzaldehyde
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
5.33
1.12
1.40
2.01
6.88
8.03
12.49
14.29
14.34
14.50
15.78
16.68
16.78
16.86
18.89
19.42
20.51
20.68
20.83
21.31
21.46
21.51
22.98
23.28
25.59
25.67
26.15
27.51
27.68
29.30
29.84 (sept)
30.36
CH4
CH3
CH3
CH3
CH3
CH2CH3
CH3
CH3
CH3
CH3
CH3
CH3
CH2
CH3
CH3
CH3
CH3
CH3
CH3CO
CH3Ar
CH3
CH3
CH2(2,4)
CH2(2,5)
CH2(4)
CH3
CH2(3,4)
CH2
CH2(3,5)
CH3CO
CD3
CH2
methane
acetonitrile
silicone grease
hexamethyldisiloxane
ethane
ethyl methyl ketone
triethylamine
n-pentane
n-hexane
ethyl acetate
diethyl ether
propane
propane
hexamethylbenzene
ethanol
propylene
acetic acid
allyl acetate
ethyl acetate
BHT
toluene
dimethylacetamide
n-pentane
n-hexane
cyclohexanone
2-propanol
tetrahydrofuran
cyclohexane
cyclohexanone
ethyl methyl ketone
(CD3)2CO signal
pump oil
30.60
30.64
30.72
31.03
31.61
32.30
34.83
34.89
35.00
35.45
36.15
36.75
37.04 (d)
37.92
41.23
41.43
42.24
45.25
47.07
49.77
52.47
54.95
54.95
55.51
57.72
58.45
58.77
60.56
63.21
63.85
64.26
CH3
(CH3)3C
(CH3)3C
CH3
(CH3)3C
CH2(3,4)
CH2(3)
NCH3
(CH3)3C
(CH3)3C
CH3
CH2CH3
CH3
NCH3
CH3
CH2
CH2(2,6)
CH2
CH2
CH3
CH3
CH2
CH3
CH3O
CH2
CH3
CH3
CH2
CH3
CH
CH2
acetone
BHA
tert-butyl alcohol
dimethylformamide
BHT
n-hexane
n-pentane
dimethylacetamide
BHT
BHA
dimethylformamide
ethyl methyl ketone
HMPA11
dimethylacetamide
dimethyl sulfoxide
dimethyl malonate
cyclohexanone
1,2-dichloroethane
triethylamine
methanol
dimethyl malonate
dichloromethane
dimethyl carbonate
BHA
ethanol
1,2-dimethoxyethane
diglyme
ethyl acetate
nitromethane
2-propanol
ethylene glycol
65.28
66.12
67.60
68.07
68.13
68.78
71.03
71.25
72.47
72.63
79.19
96.65
108.04
110.24
111.00
116.03
117.60
117.81
117.98
118.53
122.31
123.47
124.57
125.81
126.03
126.12
129.03
129.05
129.15
129.76
129.90
CH2
CH2
CH2
CH2(2,5)
(CH3)3C
CH2
CH2
CH2
CH2
CH2
CH
CCl4
CH(3,4)
CH(3,4)
CH(3,5)
CH2
CN
CHCH2
CH(2,5)
CHCH2
CH(4,5)
CH2
CH(3,5)
CO2
CH(3,5)
CH(4)
CH(3,5)
C(4)
CH
CH(2,6)
CH(3,5)
allyl acetate
diethyl ether
1,4-dioxane
tetrahydrofuran
tert-butyl alcohol
diallyl carbonate
diglyme
18-crown-6
1,2-dimethoxyethane
diglyme
chloroform
carbon tetrachloride
pyrrole
furan
BHA
propylene
acetonitrile
allyl acetate
pyrrole
diallyl carbonate
imidazole
ethylene
pyridine
carbon dioxide
BHT
toluene
toluene
BHT
benzene
toluene
benzaldehyde
130.23
132.22
133.16
133.76
134.34
135.14
135.89
136.56
137.66
138.19
138.48
140.32
143.49
148.48
150.67
152.51
153.97
155.48
157.04
162.79
167.58
170.61
170.61
170.96
172.31
192.95
193.58
205.87
206.26
208.30
210.36
CH(2,6)
C
CHCH2
CHCH2
CH
CH (4)
CH(2)
CH(4)
C(1)
C(2,6)
C(1)
C(4)
CH(2,5)
C(2,6)
CH(2,6)
C(1)
C(1)
CO
CO
CH
CO2
CO
CO
CO
CO
HCO
CS2
CO
CO
CO
CO
benzaldehyde
hexamethylbenzene
diallyl carbonate
allyl acetate
propylene
benzaldehyde
imidazole
pyridine
benzaldehyde
BHT
toluene
BHA
furan
BHA
pyridine
BHT
BHA
diallyl carbonate
dimethyl carbonate
dimethylformamide
dimethyl malonate
allyl acetate
dimethylacetamide
ethyl acetate
acetic acid
benzaldehyde
carbon disulfide
acetone
(CD3)2CO signal
ethyl methyl ketone
cyclohexanone
S13
mult
0.06
0.06
0.20
0.74
0.82
0.820.88
0.86
0.86
0.87
0.91
0.93
1.04
1.06
1.09
1.11
1.15
1.17
1.24
1.25
1.27
1.29
1.36
1.36
1.40
1.55
1.641.66
1.68
1.741.78
1.76
1.91
1.96
1.99
2.03
2.07
2.07
2.09
2.14
proton
s
CH3
s
CH3
s
CH4
m
CH3
s
CH3
m
CH3
t, 7
CH3
t, 7
CH3
t, 7.3
CH3
t, 7
CH2CH3
t, 7
CH3
d, 6
CH3
t, 7
CH3
t, 7
CH3
s
CH3
br s
CH2
t, 7
CH2CH3
br s
CH2
m
CH2
m
CH2
sept, 7.3
CH2
s
ArC(CH3)3
s
ArC(CH3)3
s
CH2
m
CH2(3,4)
m
CH2(4)
dt, 6.4, 1.5
CH3
m
CH2(3,5)
m
CH2(3,4)
s
CH3
s
CH3CO
s
CH3CO
s
CH3
s
CH3
s
CH3CO
s
CH3
s
CH3
impurity
shift
mult
proton
impurity
shift
mult
proton
impurity
silicone grease
hexamethyldisiloxane
methane
pump oil
ethane
H grease8
n-hexane
n-pentane
propane
ethyl methyl ketone
triethylamine
2-propanol
ethanol
diethyl ether
tert-butyl alcohol
pump oil
ethyl acetate
H grease8
n-hexane
n-pentane
propane
BHA
BHT
cyclohexane
pyrrolidine
cyclohexanone
propylene
cyclohexanone
tetrahydrofuran
acetic acid
dimethylacetamide
ethyl acetate
allyl acetate
acetonitrile
ethyl methyl ketone
acetone
hexamethylbenzene
2.18
2.25
2.30
2.43
2.43
2.50
2.53
2.54
2.67
2.73
2.78
2.89
2.94
3.16
3.24
3.24
3.333
3.34
3.38
3.38
3.43
3.44
3.51
3.51
3.53
3.57
3.60
3.65
3.66
3.69
3.78
3.90
4.01
4.03
4.19
4.42
4.52
s
t
s
q, 7
q, 7
p
d, 9.5
s
m
s
s
s
s
s9
s
s
s
s
q, 7
m
s
q, 76
s
m
s
s
m
s
s
s
sept, 6
s
s9
q, 7
s
s
ddd
ArCH3
CH2(2,6)
CH3
CH2CH3
CH2
CHD2
CH3
CH3
CH2(2,5)
CH3
NCH3
CH3
NCH3
CH3
OCH3
CH3
OH
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH2(2,5)
CH3
ArOCH3
CH3
CH
CH2
OH
CH2CH3
OH
CH3
CH2
BHT
cyclohexanone
toluene
ethyl methyl ketone
triethylamine
(CD3)2SO residual
HMPA
dimethyl sulfoxide
pyrrolidine
dimethylformamide
dimethylacetamide
dimethylformamide
dimethylacetamide
methanol
diglyme
1,2-dimethoxyethane
water
ethylene glycol
diethyl ether
diglyme
1,2-dimethoxyethane
ethanol
18-crown-6
diglyme
dimethyl malonate
1,4-dioxane
tetrahydrofuran
dimethyl malonate
BHA
dimethyl carbonate
2-propanol
1,2-dichloroethane
methanol
ethyl acetate
tert-butyl alcohol
nitromethane
allyl acetate
4.61
4.61
4.63
4.94
5.03
5.20
5.25
5.29
5.33
5.41
5.76
5.80
5.91
5.93
6.01
6.47
6.52
6.62
6.65
6.73
6.87
7.01
7.18
7.25
7.37
7.39
7.617.67
7.63
7.67
7.697.75
7.79
7.917.93
8.32
8.58
10.02
10.75
ddd
s
s6
dm, 10
dm, 17
ddt
ddt
ddt
ddt
s
s
m
ddt
ddt
m
dd
s
s
s
m
s
s
m
m
s
m
m
s
dd
m
m
m
s
m
s
br t
CH2
H2
OH
CH2(1)
CH2(2)
CHCH2(2)
CHCH2(2)
CHCH2(1)
CHCH2(1)
CH2
CH2
CH
CHCH2
CHCH2
CH(3,4)
CH(3,4)
OH5
ArH
OH5
CH(2,5)
ArH
CH(4,5)
CH(2,4,6)
CH(3,5)
CH
CH(3,5)
CH(3,5)
CH(2)
CH(2,5)
CH(4)
CH(4)
CH(2,6)
CH
CH(2,6)
HCO
NH
diallyl carbonate
hydrogen
ethanol
propylene
propylene
allyl acetate
diallyl carbonate
allyl acetate
diallyl carbonate
ethylene
dichloromethane
propylene
allyl acetate
diallyl carbonate
pyrrole
furan
BHA
BHA
BHT
pyrrole
BHT
imidazole
toluene
toluene
benzene
pyridine
benzaldehyde
imidazole
furan
benzaldehyde
pyridine
benzaldehyde
chloroform
pyridine
benzaldehyde
pyrrole
carbon
4.01
1.03
1.96
6.61
7.61
11.74
13.28
13.88
14.40
15.12
15.67
16.34
16.60
18.51
19.20
20.54
20.68
20.95
20.97
20.99
21.29
21.70
22.05
24.32
25.14
25.26
25.43
26.33
26.46
29.26
29.33
30.30
CH4
CH3
CH3
CH3
CH2CH3
CH3
CH3
CH3
CH3
CH3
CH2
CH3
CH3
CH3
CH3
CH3
CH3CO
CH3
CH3Ar
CH3
CH3
CH2(2,4)
CH2(2,5)
CH2(4)
CH2(3,4)
CH2(3,4)
CH3
CH2
CH2(3,5)
CH3CO
CH2
(CH3)3C
S14
impurity
shift
methane
30.38
acetonitrile
30.56
hexamethyldisiloxane
30.73
ethane
30.95
ethyl methyl ketone
31.25
triethylamine
33.48
n-pentane
34.33
n-hexane
34.42
ethyl acetate
34.76
diethyl ether
35.73
propane
35.83
propane
36.42 (d)
hexamethylbenzene
37.38
ethanol
39.52 (sept)
propylene
40.45
allyl acetate
40.72
ethyl acetate
41.32
acetic acid
45.02
BHT
45.74
toluene
46.51
dimethylacetamide
48.59
n-pentane
52.08
n-hexane
54.63
cyclohexanone
54.84
tetrahydrofuran
54.89
pyrrolidine
56.07
2-propanol
57.98
cyclohexane
58.03
cyclohexanone
59.74
ethyl methyl ketone
62.05
pump oil
62.76
BHA
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
(CH3)3C
CH3
CH3
CH2(3,4)
(CH3)3C
CH2(3)
(CH3)3C
NCH3
(CH3)3C
CH3
CH2CH3
CH3
NCH3
CD3
CH3
CH2
CH2(2,6)
CH2
CH2
CH2(2,5)
CH3
CH3
CH3
CH2
CH3O
CH2
CH3
CH3
CH2
CH2
CH2
tert-butyl alcohol
acetone
dimethylformamide
n-hexane
BHT
n-pentane
BHT
dimethylacetamide
BHA
dimethylformamide
ethyl methyl ketone
HMPA11
dimethylacetamide
(CD3)2SO signal
dimethyl sulfoxide
dimethyl malonate
cyclohexanone
1,2-dichloroethane
triethylamine
pyrrolidine
methanol
dimethyl malonate
dimethyl carbonate
dichloromethane
BHA
ethanol
diglyme
1,2-dimethoxyethane
ethyl acetate
diethyl ether
ethylene glycol
63.28
64.32
64.92
66.36
66.88
67.03
67.86
69.54
69.85
71.17
71.25
79.16
95.44
107.07
109.62
109.80
116.07
117.32
117.64
117.91
118.32
121.55
123.52
123.84
124.21
124.85
125.29
127.97
128.18
128.30
128.88
CH3
CH2
CH
CH2
(CH3)3C
CH2(2,5)
CH2
CH2
CH2
CH2
CH2
CH
CCl4
CH(3,4)
CH(3,4)
CH(3,5)
CH2
CH(2,5)
CHCH2
CN
CHCH2
CH(4,5)
CH2
CH(3,5)
CO2
CH(3,5)
CH(4)
C(4)
CH(3,5)
CH
CH(2,6)
nitromethane
allyl acetate
2-propanol
1,4-dioxane
tert-butyl alcohol
tetrahydrofuran
diallyl carbonate
diglyme
18-crown-6
1,2-dimethoxyethane
diglyme
chloroform
carbon tetrachloride
pyrrole
furan
BHA
propylene
pyrrole
allyl acetate
acetonitrile
diallyl carbonate
imidazole
ethylene
pyridine
carbon dioxide
BHT
toluene
BHT
toluene
benzene
toluene
129.10
129.45
131.10
132.18
132.71
133.55
134.52
135.15
136.05
136.20
137.35
139.12
141.16
142.82
147.44
149.58
151.47
152.53
154.16
155.76
162.29
166.91
169.54
169.97
170.31
171.93
192.63
193.08
206.31
208.72
210.63
CH(3,5)
CH(2,6)
C
CHCH2
CHCH2
CH
CH (4)
CH(2)
CH(4)
C(1)
C(1)
C(2,6)
C(4)
CH(2,5)
C(2,6)
CH(2,6)
C(1)
C(1)
CO
CO
CH
CO2
CO
CO
CO
CO
CS2
HCO
CO
CO
CO
benzaldehyde
benzaldehyde
hexamethylbenzene
diallyl carbonate
allyl acetate
propylene
benzaldehyde
imidazole
pyridine
benzaldehyde
toluene
BHT
BHA
furan
BHA
pyridine
BHT
BHA
diallyl carbonate
dimethyl carbonate
dimethylformamide
dimethyl malonate
dimethylacetamide
allyl acetate
ethyl acetate
acetic acid
carbon disulfide
benzaldehyde
acetone
ethyl methyl ketone
cyclohexanone
mult
0.07
0.08
0.20
0.85
0.85
0.89
0.89
0.90
0.96
0.96
1.09
1.12
1.12
1.16
1.20
1.27
1.28
1.29
1.33
1.39
1.40
1.44
1.61
1.671.72
1.70
1.791.84
1.80
1.94
1.96
1.96
1.97
1.97
2.02
2.06
2.08
2.13
2.16
proton
s
CH3
s
CH3
s
CH4
s
CH3
m
CH3
t, 7
CH3
t, 7
CH3
t, 7.3
CH3
t, 7
CH2CH3
t, 7
CH3
d, 6
CH3
t, 7
CH3
t, 7
CH3
s
CH3
t, 7
CH2CH3
br s
CH2
m
CH2
m
CH2
sept, 7.3
CH2
s
ArC(CH3)3
s
ArC(CH3)3
s
CH2
m
CH2(3,4)
m
CH2(4)
dt, 6.4, 1.5
CH3
m
CH2(3,5)
m
CH2(3,4)
p
CHD2
s
CH3
s
CH3
s
CH3CO
s
CH3CO
s
CH3
s
CH3CO
s
CH3
s
OH
9
s
OH
impurity
shift
mult
proton
impurity
shift
mult
proton
impurity
hexamethyldisiloxane
silicone grease
methane
ethane
pump oil
n-hexane
n-pentane
propane
ethyl methyl ketone
triethylamine
2-propanol
diethyl ether
ethanol
tert-butyl alcohol
ethyl acetate
pump oil
n-hexane
n-pentane
propane
BHT
BHA
cyclohexane
pyrrolidine
cyclohexanone
propylene
cyclohexanone
tetrahydrofuran
CD3CN residual
acetic acid
acetonitrile
dimethylacetamide
ethyl acetate
allyl acetate
ethyl methyl ketone
acetone
water
methanol
2.18
2.19
2.22
2.27
2.33
2.43
2.45
2.47
2.50
2.57
2.697
2.75
2.77
2.83
2.89
2.96
3.28
3.28
3.29
3.38
3.42
3.45
3.45
3.51
3.51
3.53
3.54
3.60
3.64
3.68
3.72
3.72
3.81
3.87
4.06
4.31
4.53
s
s
s
t
s
q, 7
q, 7
s6
s
d, 9.5
m7
m
s
s
s
s
s
s9
s
s
q, 7
m
s
s
m7
m
q, 76
s
m
s
s
s
s
sept, 6
q, 7
s
ddd
OH
CH3
ArCH3
CH2(2,6)
CH3
CH2CH3
CH2
OH
CH3
CH3
OH7
CH2(2,5)
CH3
NCH3
CH3
NCH3
CH3
CH3
OCH3
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH2(2,5)
CH3
ArOCH3
CH3
CH2
CH
CH2CH3
CH3
CH2
tert-butyl alcohol
hexamethylbenzene
BHT
cyclohexanone
toluene
ethyl methyl ketone
triethylamine
ethanol
dimethyl sulfoxide
HMPA
ethylene glycol7
pyrrolidine
dimethylformamide
dimethylacetamide
dimethylformamide
dimethylacetamide
1,2-dimethoxyethane
methanol
diglyme
dimethyl malonate
diethyl ether
diglyme
1,2-dimethoxyethane
18-crown-6
ethylene glycol
diglyme
ethanol
1,4-dioxane
tetrahydrofuran
dimethyl malonate
BHA
dimethyl carbonate
1,2-dichloroethane
2-propanol
ethyl acetate
nitromethane
allyl acetate
4.57
4.61
4.93
4.98
5.04
5.20
5.21
5.25
5.29
5.34
5.41
5.44
5.85
5.93
5.96
6.10
6.44
6.73
6.75
6.97
7.01
7.107.30
7.107.30
7.33
7.37
7.52
7.57
7.577.61
7.58
7.677.71
7.73
7.897.91
7.92
8.57
9.27
10.01
s
ddd
dm, 10
s
dm, 17
s
ddt
ddt
ddt
ddt
s
s
m
ddt
ddt
m
dd
s
m
s
s
m
m
m
s
dd
s
m
s
m
m
m
s
m
br t
s
H2
CH2
CH2(1)
OH5
CH2(2)
OH5
CHCH2(2)
CHCH2(2)
CHCH2(1)
CHCH2(1)
CH2
CH2
CH
CHCH2
CHCH2
CH(3,4)
CH(3,4)
ArH
CH(2,5)
ArH
CH(4,5)
CH(2,4,6)
CH(3,5)
CH(3,5)
CH
CH(2,5)
CH(2)
CH(3,5)
CH
CH(4)
CH(4)
CH(2,6)
CH
CH(2,6)
NH
HCO
hydrogen
diallyl carbonate
propylene
BHA
propylene
BHT
allyl acetate
diallyl carbonate
allyl acetate
diallyl carbonate
ethylene
dichloromethane
propylene
allyl acetate
diallyl carbonate
pyrrole
furan
BHA
pyrrole
BHT
imidazole
toluene
toluene
pyridine
benzene
furan
imidazole
benzaldehyde
chloroform
benzaldehyde
pyridine
benzaldehyde
dimethylformamide
pyridine
pyrrole
benzaldehyde
carbon
4.61
1.32 (sept)
1.79
2.07
6.99
8.14
12.38
14.37
14.43
14.54
15.63
16.73
16.91
16.94
18.80
19.48
20.73
21.02
21.16
21.23
21.50
21.76
23.08
23.40
25.55
25.62
26.27
26.34
27.63
27.80
29.60
30.55
CH4
CD3
CH3
CH3
CH3
CH2CH3
CH3
CH3
CH3
CH3
CH3
CH3
CH2
CH3
CH3
CH3
CH3
CH3
CH3CO
CH3Ar
CH3
CH3
CH2(2,4)
CH2(2,5)
CH3
CH2(4)
CH2(3,4)
CH2(3,4)
CH2
CH2(3,5)
CH3CO
(CH3)3C
S15
impurity
methane
CD3CN signal
acetonitrile
hexamethyldisiloxane
ethane
ethyl methyl ketone
triethylamine
n-pentane
n-hexane
ethyl acetate
diethyl ether
propane
propane
hexamethylbenzene
ethanol
propylene
acetic acid
allyl acetate
ethyl acetate
BHT
toluene
dimethylacetamide
n-pentane
n-hexane
2-propanol
cyclohexanone
tetrahydrofuran
pyrrolidine
cyclohexane
cyclohexanone
ethyl methyl ketone
BHA
shift
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
30.68
30.86
30.91
31.32
31.50
32.36
34.89
35.05
35.17
35.48
36.57
37.09
37.10 (d)
38.26
41.31
41.77
42.44
45.54
47.10
47.57
49.90
52.95
55.32
55.39
55.94
57.96
58.89
58.90
60.98
63.66
64.22
64.30
(CH3)3C
CH2
CH3
CH3
(CH3)3C
CH2(3,4)
CH2(3)
(CH3)3C
NCH3
(CH3)3C
CH3
CH2CH3
CH3
NCH3
CH3
CH2
CH2(2,6)
CH2
CH2
CH2(2,5)
CH3
CH3
CH2
CH3
CH3O
CH2
CH3
CH3
CH2
CH3
CH2
CH
tert-butyl alcohol
pump oil
acetone
dimethylformamide
BHT
n-hexane
n-pentane
BHT
dimethylacetamide
BHA
dimethylformamide
ethyl methyl ketone
HMPA11
dimethylacetamide
dimethyl sulfoxide
dimethyl malonate
cyclohexanone
1,2-dichloroethane
triethylamine
pyrrolidine
methanol
dimethyl malonate
dichloromethane
dimethyl carbonate
BHA
ethanol
1,2-dimethoxyethane
diglyme
ethyl acetate
nitromethane
ethylene glycol
2-propanol
65.55
66.32
67.72
68.33
68.74
69.09
70.99
71.22
72.47
72.63
79.17
96.68
108.31
110.49
111.35
116.12
118.06
118.26
118.26
118.47
118.86
122.78
123.69
125.89
126.28
126.38
127.76
129.23
129.32
129.61
129.94
CH2
CH2
CH2
CH2(2,5)
(CH3)3C
CH2
CH2
CH2
CH2
CH2
CH
CCl4
CH(3,4)
CH(3,4)
CH(3,5)
CH2
CHCH2
CN
CN
CH(2,5)
CHCH2
CH(4,5)
CH2
CO2
CH(4)
CH(3,5)
CH(3,5)
CH(3,5)
CH
C(4)
CH(2,6)
allyl acetate
diethyl ether
1,4-dioxane
tetrahydrofuran
tert-butyl alcohol
diallyl carbonate
diglyme
18-crown-6
1,2-dimethoxyethane
diglyme
chloroform
carbon tetrachloride
pyrrole
furan
BHA
propylene
allyl acetate
CD3CN signal
acetonitrile
pyrrole
diallyl carbonate
imidazole
ethylene
carbon dioxide
toluene
BHT
pyridine
toluene
benzene
BHT
toluene
130.07
130.42
132.61
133.20
133.83
134.78
135.40
136.33
136.89
137.62
138.13
138.90
140.20
143.74
148.39
150.76
152.42
154.02
155.66
157.26
163.31
168.07
171.31
171.32
171.68
173.21
193.60
193.64
207.43
209.88
211.99
CH(3,5)
CH(2,6)
C
CHCH2
CHCH2
CH
CH (4)
CH(2)
CH(4)
C(1)
C(2,6)
C(1)
C(4)
CH(2,5)
C(2,6)
CH(2,6)
C(1)
C(1)
CO
CO
CH
CO2
CO
CO
CO
CO
CS2
HCO
CO
CO
CO
benzaldehyde
benzaldehyde
hexamethylbenzene
diallyl carbonate
allyl acetate
propylene
benzaldehyde
imidazole
pyridine
benzaldehyde
BHT
toluene
BHA
furan
BHA
pyridine
BHT
BHA
diallyl carbonate
dimethyl carbonate
dimethylformamide
dimethyl malonate
dimethylacetamide
allyl acetate
ethyl acetate
acetic acid
carbon disulfide
benzaldehyde
acetone
ethyl methyl ketone
cyclohexanone
mult
0.08
0.16
0.18
0.85
0.880.94
0.90
0.90
0.91
0.99
1.05
1.20
1.20
1.22
1.26
1.28
1.31
1.31
1.33
1.33
1.33
1.41
1.43
1.44
1.47
1.70
1.751.78
1.871.92
1.91
1.93
1.95
2.03
2.06
2.07
2.09
2.16
2.19
proton
s
CH3
s
CH3
s
CH4
s
CH3
m
CH3
t, 7
CH3
t, 7.3
CH3
t, 7
CH3
m
CH3
t, 7
CH2CH3
t, 7
CH3
d, 6
CH3
t, 7
CH3
t, 7
CH2CH3
s
CH3
m
CH2
t, 7
CH3
br s
CH2
m
CH2
sept, 7.3
CH2
br s
CH2
s
ArC(CH3)3
s
ArC(CH3)3
s
CH2
dt, 6.4, 1.5
CH3
m
CH2(4)
m
CH2(3,5)
m
CH2(3,4)
m
CH2(3,4)
s
CH3
s
CH3CO
s
CH3
s
CH3
s
CH3CO
s
CH3CO
s
CH3
impurity
shift
mult
proton
impurity
shift
mult
proton
impurity
hexamethyldisiloxane
silicone grease
methane
ethane
H grease8
n-pentane
propane
n-hexane
pump oil
ethyl methyl ketone
diethyl ether
2-propanol
ethanol
ethyl acetate
tert-butyl alcohol
n-hexane
triethylamine
H grease8
n-pentane
propane
pump oil
BHT
BHA
cyclohexane
propylene
cyclohexanone
cyclohexanone
tetrahydrofuran
pyrrolidine
acetonitrile
ethyl acetate
acetic acid
allyl acetate
dimethylacetamide
ethyl methyl ketone
acetone
2.20
2.24
2.24
2.33
2.38
2.49
2.63
2.63
2.88
2.94
2.98
3.05
3.11
3.12
3.40
3.41
3.41
3.44
3.58
3.61
3.62
3.64
3.66
3.67
3.71
3.71
3.72
3.76
3.76
3.77
3.78
3.79
3.88
4.05
4.14
4.28
s
s
s
s
t
q, 7
s
d, 9.5
s
s
s
s
m
q, 7
s
s
s
s
q, 7
s
m
s
s
m
s
q, 7
s
s
s
s
m
s
tq
sept, 6
q, 7
s
OH
ArCH3
CH3
CH3
CH2(2,6)
CH2CH3
CH3
CH3
CH3
NCH3
CH3
NCH3
CH2(2,5)
CH2
CH3
OCH3
CH2
CH3
CH2
CH2
CH2
CH2
OH
CH2
CH2
CH2
CH2
CH3
CH2
CH3
CH2(2,5)
ArOCH3
CDH
CH
CH2CH3
CH3
tert-butyl alcohol
BHT
hexamethylbenzene
toluene
cyclohexanone
ethyl methyl ketone
dimethyl sulfoxide
HMPA
dimethylformamide
dimethylacetamide
dimethylformamide
dimethylacetamide
pyrrolidine
triethylamine
1,2-dimethoxyethane
diglyme
dimethyl malonate
methanol
diethyl ether
1,2-dimethoxyethane
diglyme
18-crown-6
water
diglyme
1,2-dichloroethane
ethanol
ethylene glycol
dimethyl malonate
1,4-dioxane
dimethyl carbonate
tetrahydrofuran
BHA
TFE-d3 residual
2-propanol
ethyl acetate
nitromethane
4.53
4.58
4.62
4.93
5.02
5.03
5.24
5.25
5.28
5.32
5.35
5.40
5.87
5.92
5.93
6.24
6.42
6.84
6.87
7.03
7.06
7.107.30
7.107.30
7.33
7.36
7.40
7.44
7.567.59
7.61
7.687.72
7.82
7.86
7.907.92
8.45
9.88
s
ddd
ddd
dm, 10
s
dm, 17
s
ddt
ddt
ddt
ddt
s
m
ddt
ddt
m
dd
m
s
s
s
m
m
s
s
m
dd
m
s
m
m
s
m
m
s
H2
CH2
CH2
CH2(1)
OH
CH2(2)
CH2
CHCH2(2)
CHCH2(2)
CHCH2(1)
CHCH2(1)
CH2
CH
CHCH2
CHCH2
CH(3,4)
CH(3,4)
CH(2,5)
ArH
CH(4,5)
ArH
CH(2,4,6)
CH(3,5)
CH
CH
CH(3,5)
CH(2,5)
CH(3,5)
CH(2)
CH(4)
CH(4)
CH
CH(2,6)
CH(2,6)
HCO
hydrogen
allyl acetate
diallyl carbonate
propylene
TFE-d3 residual
propylene
dichloromethane
allyl acetate
diallyl carbonate
allyl acetate
diallyl carbonate
ethylene
propylene
diallyl carbonate
allyl acetate
pyrrole
furan
pyrrole
BHA
imidazole
BHT
toluene
toluene
chloroform
benzene
pyridine
furan
benzaldehyde
imidazole
benzaldehyde
pyridine
dimethylformamide
benzaldehyde
pyridine
benzaldehyde
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
5.88
1.00
2.09
2.87
7.01
8.29
9.51
14.36
14.54
14.63
15.33
16.93
17.04
17.46
18.11
19.63
20.91
21.10
21.18
21.34
21.40
21.62
23.75
24.06
25.21
25.73
26.00
26.69
28.34
28.56
29.64
30.80
CH4
CH3
CH3
CH3
CH3
CH2CH3
CH3
CH3
CH3
CH3
CH3
CH3
CH3
CH2
CH3
CH3
CH3
CH3
CH3CO
CH3Ar
CH3
CH3
CH2(2,4)
CH2(2,5)
CH3
CH2(3,4)
CH2(4)
CH2(3,4)
CH2
CH2(3,5)
CH3CO
(CH3)3C
methane
acetonitrile
hexamethyldisiloxane
silicone grease
ethane
ethyl methyl ketone
triethylamine
ethyl acetate
n-pentane
n-hexane
diethyl ether
propane
hexamethylbenzene
propane
ethanol
propylene
acetic acid
allyl acetate
ethyl acetate
BHT
dimethylacetamide
toluene
n-pentane
n-hexane
2-propanol
pyrrolidine
cyclohexanone
tetrahydrofuran
cyclohexane
cyclohexanone
ethyl methyl ketone
BHA
30.96
31.01
31.07
31.85
32.35
33.17
35.69
35.76
36.07
36.28
37.21 (d)
37.76
38.23
39.06
40.06
42.13
43.16
45.28
47.43
48.45
50.67
54.00
54.46
56.17
57.55
59.40
59.52
59.68
61.5 (qp)
62.70
63.17
64.87
CH3
(CH3)3C
(CH3)3C
CH2
CO
CH2(3,4)
(CH3)3C
CH2(3)
(CH3)3C
NCH3
CH3
CH3
CH2CH3
NCH3
CH3
CH2
CH2(2,6)
CH2
CH2(2,5)
CH2
CH3
CH3
CH2
CH3
CH3O
CH3
CH3
CH2
CD2
CH2
CH3
CH2
dimethylformamide
BHT
tert-butyl alcohol
pump oil
acetone
n-hexane
BHT
n-pentane
BHA
dimethylacetamide
HMPAi
dimethylformamide
ethyl methyl ketone
dimethylacetamide
dimethyl sulfoxide
dimethyl malonate
cyclohexanone
1,2-dichloroethane
pyrrolidine
triethylamine
methanol
dimethyl malonate
dichloromethane
dimethyl carbonate
BHA
diglyme
1,2-dimethoxyethane
ethanol
TFE-d3 signal
ethyl acetate
nitromethane
ethylene glycol
66.69
67.55
67.61
68.52
69.53
70.69
70.80
71.33
72.35
72.87
73.05
78.83
97.74
108.85
111.06
112.90
116.38
118.95
119.39
119.61
120.15
122.93
124.08
126.27
126.28 (q)
126.82
126.92
127.11
129.79
129.84
130.58
130.62
CH
CH2
CH2
CH2
CH2(2,5)
CH2
CH2
CH2
(CH3)3C
CH2
CH2
CH
CCl4
CH(3,4)
CH(3,4)
CH(3,5)
CH2
CN
CHCH2
CH(2,5)
CHCH2
CH(4,5)
CH2
CH(3,5)
CF3
CH(4)
CO2
CH(3,5)
CH(3,5)
CH
CH(2,6)
C(4)
2-propanol
diethyl ether
allyl acetate
1,4-dioxane
tetrahydrofuran
diallyl carbonate
18-crown-6
diglyme
tert-butyl alcohol
1,2-dimethoxyethane
diglyme
chloroform
carbon tetrachloride
pyrrole
furan
BHA
propylene
acetonitrile
allyl acetate
pyrrole
diallyl carbonate
imidazole
ethylene
pyridine
TFE-d3 signal
toluene
carbon dioxide
BHT
toluene
benzene
toluene
BHT
130.82
131.78
132.72
133.33
134.04
136.00
136.58
137.17
137.84
138.59
139.62
139.92
140.23
144.22
149.76
150.52
153.46
153.74
157.39
159.04
166.01
170.88
175.55
175.74
175.98
177.96
196.26
197.63
214.98
218.31
221.30
CH(3,5)
CH(2,6)
CHCH2
CHCH2
C
CH
CH(2)
CH (4)
C(1)
C(2,6)
CH(4)
C(1)
C(4)
CH(2,5)
CH(2,6)
C(2,6)
C(1)
C(1)
CO
CO
CH
CO2
CO
CO
CO
CO
CS2
HCO
CH3
CO
CO
benzaldehyde
benzaldehyde
diallyl carbonate
allyl acetate
hexamethylbenzene
propylene
imidazole
benzaldehyde
benzaldehyde
BHT
pyridine
toluene
BHA
furan
pyridine
BHA
BHT
BHA
diallyl carbonate
dimethyl carbonate
dimethylformamide
dimethyl malonate
ethyl acetate
dimethylacetamide
allyl acetate
acetic acid
carbon disulfide
benzaldehyde
acetone
ethyl methyl ketone
cyclohexanone
S16
mult
0.07
0.10
0.20
0.85
0.860.91
0.860.93
0.90
0.90
0.91
1.01
1.05
1.15
1.18
1.19
1.24
1.29
1.29
1.29
1.29
1.34
1.40
1.40
1.41
1.45
1.70
1.72
1.741.76
1.851.87
1.87
1.99
2.01
2.03
2.05
2.07
2.12
2.15
proton
s
CH3
s
CH3
s
CH4
s
CH3
m
CH3
m
CH3
t, 7
CH3
t, 7
CH3
t, 7.3
CH3
t, 7
CH2CH3
t, 7
CH3
d, 6
CH3
t, 7
CH3
t, 7
CH3
t, 7
CH2CH3
br s
CH2
m
CH2
m
CH2
br s
CH2
sept, 7.3
CH2
s
CH3
s
ArC(CH3)3
s
ArC(CH3)3
s
CH2
dt, 6.4, 1.5
CH3
m
CH2(3,4)
m
CH2(4)
m
CH2(3,5)
m
CH2(3,4)
s
CH3
s
CH3CO
s
CH3
s
CH3
s
CH3CO
s
CH3CO
s
CH3
impurity
shift
mult
proton
impurity
shift
mult
proton
impurity
hexamethyldisiloxane
silicone grease
methane
ethane
pump oil
H grease8
n-hexane
n-pentane
propane
ethyl methyl ketone
triethylamine
2-propanol
diethyl ether
ethanol
ethyl acetate
H grease8
n-hexane
n-pentane
pump oil
propane
tert-butyl alcohol
BHT
BHA
cyclohexane
propylene
pyrrolidine
cyclohexanone
cyclohexanone
tetrahydrofuran
acetic acid
ethyl acetate
acetonitrile
allyl acetate
dimethylacetamide
ethyl methyl ketone
acetone
2.19
2.21
2.32
2.34
2.50
2.58
2.64
2.65
2.80
2.86
2.92
2.99
3.31
3.31
3.34
3.35
3.35
3.44
3.49
3.52
3.58
3.59
3.60
3.61
3.64
3.66
3.71
3.72
3.72
3.74
3.78
3.92
4.09
4.34
4.56
s
s
s
t
q, 7
q, 7
d, 9.5
s
m
s
s
s
p
s
s
s
s
s
q, 7
s
m
s
q, 7
m
s
s
m
s
s
s
s
sept, 6
q, 7
s
ddd
CH3
ArCH3
CH3
CH2(2,6)
CH2CH3
CH2
CH3
CH3
CH2(2,5)
CH3
NCH3
CH3
CD2H
NCH3
CH3
OCH3
CH3
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH2(2,5)
ArOCH3
CH3
CH3
CH2
CH
CH2CH3
CH3
CH2
hexamethylbenzene
BHT
toluene
cyclohexanone
ethyl methyl ketone
triethylamine
HMPA
dimethyl sulfoxide
pyrrolidine
dimethylformamide
dimethylacetamide
dimethylformamide
CD3OD residual
dimethylacetamide
methanol
diglyme
1,2-dimethoxyethane
dimethyl malonate
diethyl ether
1,2-dimethoxyethane
diglyme
ethylene glycol
ethanol
diglyme
18-crown-6
1,4-dioxane
tetrahydrofuran
BHA
dimethyl malonate
dimethyl carbonate
1,2-dichloroethane
2-propanol
ethyl acetate
nitromethane
allyl acetate
4.56
4.61
4.85
4.87
4.91
5.01
5.21
5.25
5.30
5.34
5.39
5.49
5.82
5.94
5.94
6.08
6.40
6.71
6.72
6.92
7.05
7.16
7.16
7.33
7.44
7.49
7.567.60
7.667.70
7.67
7.85
7.90
7.907.93
7.97
8.53
10.00
s
ddd
s
s
dm, 10
dm, 17
ddt
ddt
ddt
ddt
s
s
m
ddt
ddt
m
dd
s
m
s
s
m
m
s
m
dd
m
m
s
m
s
m
s
m
s
H2
CH2
OHd
OH
CH2(1)
CH2(2)
CHCH2(2)
CHCH2(2)
CHCH2(1)
CHCH2(1)
CH2
CH2
CH
CHCH2
CHCH2
CH(3,4)
CH(3,4)
ArH
CH(2,5)
ArH
CH(4,5)
CH(2,4,6)
CH(3,5)
CH
CH(3,5)
CH(2,5)
CH(3,5)
CH(4)
CH(2)
CH(4)
CH
CH(2,6)
CH
CH(2,6)
HCO
hydrogen
diallyl carbonate
BHA
water
propylene
propylene
allyl acetate
diallyl carbonate
allyl acetate
diallyl carbonate
ethylene
dichloromethane
propylene
allyl acetate
diallyl carbonate
pyrrole
furan
BHA
pyrrole
BHT
imidazole
toluene
toluene
benzene
pyridine
furan
benzaldehyde
benzaldehyde
imidazole
pyridine
chloroform
benzaldehyde
dimethylformamide
pyridine
benzaldehyde
carbon
4.90
0.85
1.99
2.10
6.98
8.09
11.09
14.39
14.45
14.49
15.46
16.80
16.90
17.19
18.40
19.50
20.56
20.71
20.88
21.32
21.38
21.50
23.38
23.68
25.27
25.86
26.29
26.48
27.96
28.16
29.39
30.67
CH4
CH3
CH3
CH3
CH3
CH2CH3
CH3
CH3
CH3
CH3
CH3
CH3
CH3
CH2
CH3
CH3
CH3
CH3
CH3CO
CH3
CH3Ar
CH3
CH2(2,4)
CH2(2,5)
CH3
CH2(4)
CH2(3,4)
CH2(3,4)
CH2
CH2(3,5)
CH3CO
CH3
S17
impurity
shift
methane
30.82
acetonitrile
30.91
hexamethyldisiloxane
31.15
silicone grease
31.35
ethane
31.61
ethyl methyl ketone
32.73
triethylamine
35.30
n-pentane
35.36
n-hexane
35.50
ethyl acetate
35.83
diethyl ether
36.89
propane
37.00 (d)
hexamethylbenzene
37.34
propane
38.43
ethanol
40.45
propylene
41.60
acetic acid
42.61
allyl acetate
45.11
ethyl acetate
46.96
dimethylacetamide
47.23
BHT
49.00 (sept)
toluene
49.86
n-pentane
52.83
n-hexane
54.78
2-propanol
55.25
cyclohexanone
55.96
pyrrolidine
58.26
tetrahydrofuran
59.06
cyclohexane
59.06
cyclohexanone
61.50
ethyl methyl ketone
63.08
acetone
64.30
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
(CH3)3C
(CH3)3C
(CH3)3C
CH2
CH3
CH2(3,4)
CH2(3)
(CH3)3C
NCH3
(CH3)3C
CH3
CH3
CH2CH3
NCH3
CH3
CH2
CH2(2,6)
CH2
CH2
CH2(2,5)
CD3
CH3
CH3
CH2
CH3
CH3O
CH2
CH3
CH3
CH2
CH3
CH2
BHA
tert-butyl alcohol
BHT
pump oil
dimethylformamide
n-hexane
n-pentane
BHT
dimethylacetamide
BHA
dimethylformamide
HMPAi
ethyl methyl ketone
dimethylacetamide
dimethyl sulfoxide
dimethyl malonate
cyclohexanone
1,2-dichloroethane
triethylamine
pyrrolidine
CD3OD signal
methanol
dimethyl malonate
dichloromethane
dimethyl carbonate
BHA
ethanol
diglyme
1,2-dimethoxyethane
ethyl acetate
nitromethane
ethylene glycol
64.71
66.14
66.88
68.11
68.83
69.35
69.40
71.33
71.47
72.72
72.92
79.44
97.21
108.11
110.33
111.30
116.04
118.06
118.22
118.28
118.74
122.60
123.46
125.53
126.11
126.29
126.31
129.20
129.34
129.49
129.91
CH
CH2
CH2
CH2
CH2(2,5)
CH2
(CH3)3C
CH2
CH2
CH2
CH2
CH
CCl4
CH(3,4)
CH(3,4)
CH(3,5)
CH2
CN
CHCH2
CH(2,5)
CHCH2
CH(4,5)
CH2
CH(3,5)
CH(3,5)
CH(4)
CO2
CH(3,5)
CH
C(4)
CH(2,6)
2-propanol
allyl acetate
diethyl ether
1,4-dioxane
tetrahydrofuran
diallyl carbonate
tert-butyl alcohol
diglyme
18-crown-6
1,2-dimethoxyethane
diglyme
chloroform
carbon tetrachloride
pyrrole
furan
BHA
propylene
acetonitrile
allyl acetate
pyrrole
diallyl carbonate
imidazole
ethylene
pyridine
BHT
toluene
carbon dioxide
toluene
benzene
BHT
toluene
130.12
130.64
132.53
133.25
133.71
134.61
135.60
136.31
137.96
138.35
138.85
139.09
141.36
143.68
149.04
150.07
152.85
154.34
156.28
157.91
164.73
168.70
172.41
172.89
173.32
175.11
193.82
194.11
209.67
212.16
214.69
CH(3,5)
CH(2,6)
C
CHCH2
CHCH2
CH
CH (4)
CH(2)
C(1)
CH(4)
C(1)
C(2,6)
C(4)
CH(2,5)
C(2,6)
CH(2,6)
C(1)
C(1)
CO
CO
CH
CO2
CO
CO
CO
CO
CS2
HCO
CO
CO
CO
benzaldehyde
benzaldehyde
hexamethylbenzene
diallyl carbonate
allyl acetate
propylene
benzaldehyde
imidazole
benzaldehyde
pyridine
toluene
BHT
BHA
furan
BHA
pyridine
BHT
BHA
diallyl carbonate
dimethyl carbonate
dimethylformamide
dimethyl malonate
allyl acetate
ethyl acetate
dimethylacetamide
acetic acid
carbon disulfide
benzaldehyde
acetone
ethyl methyl ketone
cyclohexanone
mult
proton
impurity
shift
mult
proton
impurity
shift
mult
proton
impurity
0.18
0.28
0.82
0.88
0.99
1.17
1.17
1.17
1.24
1.24
1.26
1.30
1.70
1.701.75
1.851.90
1.87
1.88
2.06
2.07
2.08
2.08
2.13
2.19
2.22
2.40
2.57
2.61
s
s
s
t, 7.3
t, 7
t, 7
t, 7
d, 6
s
t, 7
t, 7
sept, 7.3
dt, 6.4, 1.5
m
m
m
m
s
s
s
s
s
s
s
t
q, 7
d, 9.5
CH4
CH3
CH3
CH3
CH3
CH3
CH3
CH3
CH3
CH2CH3
CH2CH3
CH2
CH3
CH2(4)
CH2(3,5)
CH2(3,4)
CH2(3,4)
CH3
CH3CO
CH3
CH3CO
CH3
CH3CO
CH3
CH2(2,6)
CH2
CH3
methane
hexamethyldisiloxane
ethane
propane
triethylamine
diethyl ether
ethanol
2-propanol
tert-butyl alcohol
ethyl acetate
ethyl methyl ketone
propane
propylene
cyclohexanone
cyclohexanone
pyrrolidine
tetrahydrofuran
acetonitrile
ethyl acetate
acetic acid
dimethylacetamide
allyl acetate
ethyl methyl ketone
acetone
cyclohexanone
triethylamine
HMPA
2.71
2.85
2.90
3.01
3.06
3.07
3.18
3.34
3.37
3.37
3.56
3.60
3.60
3.61
3.65
3.65
3.67
3.69
3.74
3.75
3.78
3.80
4.02
4.14
4.40
4.62
s
s
s
s
s
m
q, 7
s
s
s
q, 7
s
s
m
q, 7
s
m
s
m
s
s
s
sept, 6
q, 7
s
ddd
CH3
CH3
NCH3
CH3
NCH3
CH2(2,5)
CH2CH3
CH3
OCH3
CH3
CH2
CH2
CH2
CH2
CH2
CH2
CH2
CH3
CH2(2,5)
CH2
CH3
CH2
CH
CH2CH3
CH3
CH2
dimethyl sulfoxide
dimethylformamide
dimethylacetamide
dimethylformamide
dimethylacetamide
pyrrolidine
ethyl methyl ketone
methanol
diglyme
1,2-dimethoxyethane
diethyl ether
1,2-dimethoxyethane
dimethyl malonate
diglyme
ethanol
ethylene glycol
diglyme
dimethyl carbonate
tetrahydrofuran
1,4-dioxane
dimethyl malonate
18-crown-6
2-propanol
ethyl acetate
nitromethane
allyl acetate
4.69
4.79
4.95
5.06
5.30
5.32
5.37
5.40
5.44
5.90
5.99
5.99
6.26
6.51
6.93
7.14
7.45
7.57
7.577.66
7.767.80
7.78
7.87
7.92
7.977.99
8.52
9.96
ddd
s
dm, 10
dm, 17
ddt
ddt
ddt
ddt
s
m
ddt
ddt
m
dd
m
s
m
dd
m
m
s
m
s
m
m
s
CH2
HOD
CH2(1)
CH2(2)
CHCH2(2)
CHCH2(2)
CHCH2(1)
CHCH2(1)
CH2
CH
CHCH2
CHCH2
CH(3,4)
CH(3,4)
CH(2,5)
CH(4,5)
CH(3,5)
CH(2,5)
CH(3,5)
CH(4)
CH(2)
CH(4)
CH
CH(2,6)
CH(2,6)
HCO
diallyl carbonate
D2O residual
propylene
propylene
allyl acetate
diallyl carbonate
allyl acetate
diallyl carbonate
ethylene
propylene
allyl acetate
diallyl carbonate
pyrrole
furan
pyrrole
imidazole
pyridine
furan
benzaldehyde
benzaldehyde
imidazole
pyridine
dimethylformamide
benzaldehyde
pyridine
benzaldehyde
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
shift
carbon
impurity
1.47
2.31
7.87
9.07
13.92
14.77
17.47
21.00
21.03
21.09
21.15
24.38
24.77
25.67
25.86
27.50
29.49
30.29
30.89
32.03
35.03
CH3
CH3
CH2CH3
CH3
CH3
CH3
CH3
CH3
CH3
CH3
CH3CO
CH3
CH2(4)
CH2(3,4)
CH2(3,4)
CH2(3,5)
CH3CO
(CH3)3C
CH3
CH3
NCH3
acetonitrile
hexamethyldisiloxane
ethyl methyl ketone
triethylamine
ethyl acetate
diethyl ether
ethanol
allyl acetate
acetic acid
dimethylacetamide
ethyl acetate
2-propanol
cyclohexanone
tetrahydrofuran
pyrrolidine
cyclohexanone
ethyl methyl ketone
tert-butyl alcohol
acetone
dimethylformamide
dimethylacetamide
36.46 (d)
37.27
37.54
38.76
39.39
42.02
42.13
46.83
47.19
49.5012
53.65
55.81
58.05
58.67
58.67
62.32
63.17
63.22
64.88
66.42
66.52
CH3
CH2CH3
CH3
NCH3
CH3
CH2(2,6)
CH2
CH2(2,5)
CH2
CH3
CH3
CH3
CH2
CH3
CH3
CH2
CH2
CH3
CH
CH2
CH2
HMPAi
ethyl methyl ketone
dimethylformamide
dimethylacetamide
dimethyl sulfoxide
cyclohexanone
dimethyl malonate
pyrrolidine
triethylamine
methanol
dimethyl malonate
dimethyl carbonate
ethanol
diglyme
1,2-dimethoxyethane
ethyl acetate
ethylene glycol
nitromethane
2-propanol
diethyl ether
allyl acetate
67.19
68.68
68.81
70.05
70.14
70.36
71.49
71.63
96.73
107.83
110.23
118.75
119.03
119.06
119.68
122.43
125.12
129.48
130.09
132.48
CH2
CH2(2,5)
CH2
CH2
CH2
(CH3)3C
CH2
CH2
CCl4
CH(3,4)
CH(3,4)
CHCH2
CHCH2
CH(2,5)
CN
CH(4,5)
CH(3,5)
CH(3,5)
CH(2,6)
CHCH2
1,4-dioxane
tetrahydrofuran
diallyl carbonate
diglyme
18-crown-6
tert-butyl alcohol
1,2-dimethoxyethane
diglyme
carbon tetrachloride
pyrrole
furan
diallyl carbonate
allyl acetate
pyrrole
acetonitrile
imidazole
pyridine
benzaldehyde
benzaldehyde
allyl acetate
132.76
134.70
136.11
136.65
138.27
143.57
149.18
157.78
163.96
165.53
170.12
174.57
174.78
175.26
177.21
191.67
197.25
215.94
218.43
221.22
CHCH2
CH (4)
C(1)
CH(2)
CH(4)
CH(2,5)
CH(2,6)
CO
CO
CH
CO2
CO
CO
CO
CO
HCO
CS2
CO
CO
CO
diallyl carbonate
benzaldehyde
benzaldehyde
imidazole
pyridine
furan
pyridine
diallyl carbonate
dimethyl carbonate
dimethylformamide
dimethyl malonate
dimethylacetamide
allyl acetate
ethyl acetate
acetic acid
benzaldehyde
carbon disulfide
acetone
ethyl methyl ketone
cyclohexanone
S18
References
(1) Gottlieb, H. E.; Kotlyar, V.; Nudelman, A. J. Org. Chem. 1997, 62, 7512.
(2) Except for the compounds in solutions 810, as well as the gas samples,
hexamethylbenzene, and the corrected values (vide supra), all data for the
solvents CDCl3, C6D6, (CD3)2CO, (CD3)2SO, CD3CN, CD3OD, and D2O were
previously reported in ref 1.
(3) A signal for HDO is also observed in (CD3)2SO (3.30 ppm) and (CD3)2CO (2.81
ppm), often seen as a 1:1:1 triplet (2JH,D = 1 Hz).
(4) Splitting pattern observed as a triplet of a non-first-order ABX pattern.
(5) Not all OH signals were observable.
(6) In some solvents, the coupling interaction between the CH2 and the OH protons may
be observed (J = 5 Hz).
(7) In CD3CN, the OH proton was seen as a multiplet at 2.69 ppm, as well as extra
coupling to the CH2 peak.
(8) Apiezon-brand H grease.
(9) In some solvents, the coupling interaction between the CH3 and the OH protons may
be observed (J = 5.5 Hz).
(10) Pyrrolidine was observed to react with the solvent (CD3)2CO.
(11) Phosphorus coupling was observed (2JPC = 3 Hz).
(12) Internal reference; see Experimental Section in text.
S19