Beruflich Dokumente
Kultur Dokumente
Syllabus
Course Material
Lecture notes- powerpoint slides/course notes
Text book (Watson 7th edition)- only for additional
reading
Audio/Video podcasts
https://ccle.ucla.edu/ (Course website)
Grading- 2 EXAMS
Pyle
May 4
Wall
June 11
Make-up Policy:
No make up examination will be given. If you are unable to take an
examination due to illness or other emergency, you are responsible for
contacting the Life Sciences Core Curriculum Office before the
examination. You are required to have written verification from a physician
regarding the illness or emergency.
Policies
Exams will cover predominately lectures and textbook
as a reference.
Re-grade requests are accepted only with demonstrated
error (rare). Requests must be submitted to Core office
by Friday of week following exam with typed
explanation of issue.
Entire exam will be re-graded by TA.
Exams will be left with the TA.
No excuses for missing exam. No-Make-up examscontact LS Core if emergency.
Office Hours: Monday-Friday 9-12PM
& 1-4PM
Email: lscore@lifesci.ucla.edu
LS3 TAs: (see TAs for office hrs)
Yuqian Chen
angelachen0225@g.ucla.edu
Yasmin Ghochani yghochani@ucla.edu
Soyon Kim
soyonkim@ucla.edu
Julia Lipianskaya jlipianskaya@ucla.edu
Brittany Ulrich
bulrich@ucla.edu
LS3 TUTORS
Peer Learning
https://www.lscore.ucla.edu/lsplf.php
Assessment (not graded): Surveys via email and Concept Inventory (CI) exam will be
given in discussion sections (1st and 10th week) to assess class learning in LS3. This
is not a part of your grade but participation would be appreciated.
Lecture
1
Molecular Components
March 31, 2015
Pyle
Xenopus
C. Elegans
Bacteria
Drosophila
Yeast
Plants
http://ed.ted.com/lessons/the-operating-system-of-life-george-zaidan-and-charles-morton
Microscopy:
Visualizing Cells and
Cell Components
Electron Microscopeviruses, lipids, actin,
DNA
Light Microscopebacteria, cells,
mitochondria
Human Vision- eggs,
embryos, mice
Macromolecules
Macromolecules have a
mass of greater than a few
thousand daltons
Typically have a higher
order structure
Chemical interactions
regulate stability of
macromolecules
Atoms in Macromolecules
Six most popular
atoms in living
systems:
Hydrogen,
Carbon,
Nitrogen,
Phosphorus,
Oxygen
Sulfur
Covalent bonds
------
-- Interactions
!Noncovalent
bonds
!!
Single bond
Double bond
- fatty acid:
- Amino acids:
- base:
Schematic of Polymer
Formation
-In hydrolysis, water is added to break covalent bond between monomers and in
condensation, water is removed to bond them together.
-Condensation reactions store energy and hydrolysis typically releases energy
1 Cell!
14!
10!
Cells!
Differentiated Neurons
Cell Division
A process by which a cell
duplicates its own material and
divides into two cells."
"G1"
"G2/M"
"S"
What happens if the cell
progresses abnormally through
this cycle??"
~ 20,000 genes!
~ 20,000 genes!
Transcription
DNA
Translation
RNA
Protein
Macromolecules are key players that regulate every aspect of molecular biology!
Course Overview
1. Structure and function of
DNA, RNA, and protein
2. Basic Molecular Biology Processes
Replication
Transcription
Translation
Regulation of gene expression
Genetic variations
Transcriptome and RNA silencing
3.