BLNBHIVOIGSW V7 asusnay sulovsu “ye ‘oppRayeoypene sor oreo i) smears 2p phpuos wf s6isap0 jas elustony PEALE sTURTEUNIS (yeu AGEIeL 270p eI Tams ‘soncen ajs0 “seusape wiseos ap dq aus ua cmp pdnp ‘osinape syyiers ancud = ‘prvarpesur op [22p “AIpou ssloe9 oan 1 soruremposrtaey s]HOpOH 2=129)9 = -muyep ep sofa sensapomy rans we oie]? iseigo Ydasp si Hfopoorvorodoue SLNVdOd STaLNSINVOIGSW ‘vINSGNSdad ‘SSVOLNSWVOIGSIN. SinoV STULLVOMOLNI ‘SINAINVOIGSIN 3G asnGoud AODOTOLVd SUYyis IS asuaAav 2uloway “€ land poe sag zoetunowenn) (590) os eine ‘puome eaemeantny W (fenenwowle (Cifele clinice a medicementelor acis de aseme- spins Tae , produse de digitlice asupra i oir cave sate nesses 0 enpraveghere sae ba Re RES Tg BET Se TS BE atetetor apa cu att mai mare cp cat doze ras ae Terepeul eet mporsl DL SIDE $0, care DL, 50 = doze leit ta 50 % lowe seit be WS om steam in 50'S ee askance or soso ne1 ‘omsoyrte coz ea =P | ‘aso ajgnvaodsa: jens? op amend woe sossed juauma yo grepaide og vfeazng et fam eicao0u poydio 29 co “x fmuozour Soap a8 panzqpooy 2099-129 9p 3982] IP “si Syumsuen o¢ govjoqmiau simmons meecoy ‘sjupo sowsoe sopmeqmaN nin Team earsuieom sued ong sows “ap “ar RyREONNNYS 8 pom eazpRoE aoa STREP OP sh09-s 9p of ‘pose Bp: syennougl yens 20 =TESuNput snore aute 1S 2uzeybupry “RprEerwoH? 2p “oun gud sorrersnsone ayaa sic. TEPER? mmporg if onousd vensens un no 2oFeED 2 © proauroue> vaLouuiofmini iu 38 slunisqns 2foum ¥9 osu RE, ouonoyemsie “epioneed ‘ormpmments sscadzotomm@ % 280}0} aeoRtOION TENE vusfemus 95: no cweouesypotn aemectonted sojoyesamegipoae ‘emsfoxs oje9 sceo8 cyt Year yénp seyqo — Ss ‘mo “mmdnouss ofp aquamstaed yogtpou imposes idosp me susdoima 2790947 38 (moonenont igasoapat) Syeryoosorsreoupmy HF EmgD oie sp tiem 2[o2op ‘vere sezounjendans “somemns o[crae] * (Boar 2 sme oe suefi00 wlemajyrar nee owe ooe 40um Those EIS sid greproonmsonam 9p ‘uzuoypou ap set qa cosy “ownif soyresoway siuaptans 800 ‘mod toundss no sojaymenseoonime rareto fan qresiaayod “njdaioxo 2p ‘sqsondsjeinae nes siawweeyomesy “or -exypooeturey nes sRouisoormm; TES su upd ‘anfeniod mes misrBioms 9p Tet ‘38 oun gipbrep ‘copwey sust0Ns} BEES? “3p tod srvonieuoorpow squmfsauoruyCateva reacfil Kdlosinerazice provocate de medieamente (Gece la es)See ee Jotannegias yooeeeyot yay eesasverm| oat seg sorweee oes | eee # zocor “Se enerome sens)“ nmemy Soeoes poy a svi asia “sur on symone pusuo ~ someSues eade Br vey -sovowaurompt Spimd sopsyss ea RETA va {818 promotor sito ‘supucpBorrasd ‘owes sonst ‘uray ‘puny — reiouR copou Haisqys ns apnoseve5 ‘syozea © ‘ayporseer ~ 2ynjso oun wiapeaéns gredeoe ‘ammo ‘auygea! nes G8] no monetace tat catdea sp sissouced yane 1 stefpoan sora setar spbSaye0 wip und 28) stg aoqdors syemeosied uy stacey wor vate p ahr op [88 ouop fou de op a 8iopo omnloooyy ‘omy squeal ‘msyosoeur upd osoqatoup ce nino "SIasOe Blows op undp epg uorapoormy Somuuojsuen yovosout nas aanes osen > sfumegns som earesoqK> no “aneEegse BEpoe geyeny gummed eseecy “opssaron viepuine of” 2 Mioidesar aney nes ospee EOP aN eeaderpasd 9 = 89 ¥5 ‘unum SfenEapa! ofaaserp eRe S9TEMe Bftpuoo ey “rows099, 2p aiejeates 1 sopupsaics ezeq ad yezioaud oF aisod ‘mo sy soiGsoye soytfooss ymaery “so}30| = We 28 so[UNTED BEM LICr EY es aomeoIpem ep TORE aureo} Shige oor some ges emo ‘ommgnfomnay yeromto ‘reatepoun sus0ytan fasvodates nays a | 2518:0]8 aesnepe oftiowsy, rose “uis1we8:0 Hip gppdedod o ase grpeoad o zo19usqv ‘no Masqen03 wasezo] Head pen(b0> ses Bsuaaay auLovau “ELe es FOR FIncs[out eect owes eT “rm eats ean ae RE TP, Wea oe eee utes ee ee sf pd toe ee Sra! rer raee > 29 [8 opaseidoo: iuincs © nied yoppods as wisusty japonis ot oeX Afrasteamere TABELUL 200 (coum) ‘msbot state oo Fig, 66 ~ Diese j- arate cunoscnte es foarte ant Eontraindioata. Trebule excluse ir te locel, con “ulfamide, Este nece- 127 126scr ‘espmorpeng Fup op nad uocun ‘RO nes MODES 2p ‘aeadse wopiqtit 10d seisape oqnlono, SLNBWVOIG3W 3a Ssnaoua BOISMOLV TWHyLS “ze sjesisenss esohold eed edopoet = sas "HONE 2p 2zm09 10% omnes ‘ulosoon[s ‘ane s0ui03 pooeee HF 9p vunaT greaced ateo “ymmporoussd “oid jniay 2p SoPBuswespeenag (Gave =20p uy). euosjay “eprmeTo od ormsayrse yexede. raat af erngaa Beon0ud tod syuemmeaipom ap SLD O ainaweoian sa Sit net a Coe asngous Suvinosynoid “evo s51eovolve wows ze * 824 umzusjodar myumsyomsy ayo ~ 2 = sejtoures4 sodorss trmuw eaorToo weeosoid (qaomporre "apr lenis sranme epmIA nGOd yn\qeevoderpm eos “ope aise fezes prascuespaus ramndsp +5 soareoop "purnodiat ows seworeeueorp {23 seoferd copes eaiaseomnoy ee AJSRPES “soHojored ume ays amet meson sp aid 8 oor eer; poses comet soo) emma tenon “enc tera Tee Pow peoreyygie sonore? é ges ypramerence “oosraqnene Toor Sromeseoe soe sores sum omementy ‘ooaord yod a] aura syusuo1pour 7 stpredpouad § mppBupe aye TEIN AopsNUsUD|S (MPAIU ef sooo eI ‘anu op pivot 2p 2189 sep ‘wosrer omy. sp spine) rouiseds edioopme opt sensaey yoSispe-gmiew op aoa (HOMOue (ees “onuooen ejloyat aco Gio givsioayy "eur woo weuto) sfney slujzorvo9 fo poses fnow mip gzsefeefoep of "oma ae em § casio jod eeuouose 2p ‘sopsedsoqnose —— gu 2p rqasosp smash ‘poe sues: ete tm adap "Zor wap 0 pnp Ton DOO STI 9p 2189 Biasoag 1 aed 0 ea001d ays0d (No “oqney Teareymezor> 29 psnp" cnpom otis ais njdimaes codoyeureg migureses pupiosze “gompau ei22180 weno vod awestenpeM Sse Com mpoiays yertee) surmmps siscend cis sqeomss = tuiusd soqammpeg savers 18 teyoBoes (ojos “asso oe no ope “sorpamr rama cud ‘onesd syeepiese som = shewiyoud op ofuinsgar ezvonap 36 eld nd oq "Says op sojaqond rammarnodsty sp umin mse moprouteig “Tye soosd nes euicortomoq ‘CRanDae up wee souayued) remy sjeomaye genre Steamainy “somesousowpa nes soigacte ‘somot stsjaesear som efivoacnay ad ‘wueBups nudase amorgangp pasion yuan “SS Ata “lamxs sod SINSUNSOTy BuNaWvoIaaN 3a_ssndoud InTseNys 31v 30D07OLvd Steyls ‘eee unsbaye aie (8 preacey steoq mp orumax 8 sqemmgins yrecaesbe ‘pouahied eyfyae Hosoron pugetioats Tae poyocnoid "Jordnore: rarcori se produce hemoplobiurie 5 prot at # ‘smal retrompective an dovedit 0 ngouri ucbule flosite si doosto eu prudent, mk se eS Tleciuailor trombeembolice iad mult intrvaal Ginwe doze, to foxcie eepbotbi. emote ime bork cerebs ‘par bemoragil le nivelul i, raroori singerdri ms- bone dal 3.28. STARILE PATOLOSICE ebliefsbuloiicatile ete) oa necro eile favori= RENALE PRODUSE DE tubule. Frecvenje acest accident este seam: MEDICAMENTE fia! aed peute cefotch, Asosires ot tte subsiane nefzotosioe (gatbiotice amino samente ~ enticoagu slicozidiee ele.) seu cu furos crests ‘siraile & supradozare), parcetamolal Gn roidiene, slopurinal, compus! rogucerea inavesoasa, iterul Jina gi tceritina, doaele pesiclint, Istamoxeful, pot provoes, de (Gromul este fa general benign. Uneor pa- ogenia este alorgic#, afectarea rinichisini tind tosoqied de erupf cutanate, febré, 135Date SOEs joie Saas TNS es Seine mopmeo Gramone Spey Sees eee SENG “PRSGH ‘eesuese Wormnagiy on foarte Bf aeonee come qaopsatoam T Seemeeee (Guow> s00) pera“ sasopp sasone “Trenrces see “ony (aise Fa emeao of ed sor ever Peoria | oueend et TNE “G HPpaerms Fepihaay Ta re 2 ipnoI seme Soon Sopenowtee Dhotle [ome ce ymree Baia oy ‘erpesd rod of s1eo sumouteoqpour 2piediayd FE ayemar oyforoed ug ae ages “queimoyS my sireyaaijo sent sxafaai09 ‘9p yueundap se-apupiotep Yorsispe panies{| on | | Sonn ipou sarmnay insu; no qeemog ep soucaeaat oo “S! pvr 2ys20p soy ran apn "papSruOpE (0 ‘ated nes yejorss BELSTUOAS nneod me = Rene snp SiNswwolaay so. (2eeieredoa iter ypoqnem mm varios BOlivesH 3 ‘stents vf ‘ipaiop eg “simsice ee 3 Eines a foeea tests ee fe “Bre Mom ango enjons tod Iep one “K emnedoq wp 29 “awed azmjcojo “snus seayiiep sm rent tn ad “awaoud one ‘onmsetoo smmsy exede 5 et : ‘sdoptnom “termmossq> "Tete hoco meoapeces eae aromas a no aog Te wouromeres mars RroIsuOTESIS op BzMUD “woUSUIOSE OP“ “yoyre ‘soisoyoonce sxe 1 gonlane ‘on united “20304 Up a pg afciowep 3 yee eee eee sundnsasd ¢g -otxoy sores sjupe anuod jozummopad ade 8489 sep ‘porBojounts: pam ‘omonsy "BiDA2s mmoy eevep aust: Foowen aa mAeden ousyouns Uy qiste> a sot0355 BN ‘ne ap yiincuioa "wuozenaitisy “aoa crow “rooeessjounmy “ezoyoojamelse 2s 1g ted stusuresypour SANSWYOIOSNN 30 ty sede aro 219 8 2 "yseorsmp wos 5 “areas ay Ws 200 Sep meme etme pepas [iis ad prescoau 3i¢q "78 s20p 25080}03 36. PES guint e-7 uy — Zo|damp © SmIoe) 9D soipRooiomjus soRo|gNE® AOUN w=}EyPIXOIOIO ‘Wrayan ogg, sised curses gfenascass -ordang ame nutad gone; pom 220 epmoons EAH 9 oa OUNGE sso FajoNMOaNY [RMON 2350 gre “32 moory puz> joe sxete 9p ae ayy ns [yen geo op commer soneusetd eaisoo 8 pf 28a op s20cl ve up mins japesaany #6 3—SuSRIe MPN “Si Foon, say ap oqoizmns nnd sqescopey injure senspioid nes eaeneranp apd smearaets vod spspRoongoatas te -grsoy ‘Riotesmuien esmado tanp tater ‘re ra sHfos! nw cfovoucway “pyr 7 sad op ey Eages emma (ome 5 ap spas BIE IAN of aed op atieo o Sy8a oor a88. INTOXIGATIILE ACUTE pot produce acccasi reacic. Patogenia este EDICAMENTOASE gies sau toxict. Disgnosticul 8.8.1. CUANTIFICAREA TOXICIT DIGAMENTELOR, toxice, observate 18 in jeolagi, su un caracter gradat cresciad 0 dati oa doze. Observate asupra ‘raRELo sack Princtpalcle react catanate medicamentoase si uncle dintre ipalele react Sunjale care le proveacl REACTILE CUTANATE PRODUSE DE MEDIGAMENTEoreod aeeorasureapant iomsgas eoimore <0 Te Ryu oo 8 Or aamy— Ho amar OE ojso op — youttdno pesy Saou 9 srlomy wy mel? op ame if maton 4 9p roovloey emmy geetea ‘speroommedas lone of sunopea man wamionor Wwo v1 BSvOLNaMIVOIGaN Binoy SuULVOXOIN! ‘zee mmo nf sea8opog 26 ayermsuecrpom (ous 05 ase “Goma eet 32 ono ap sajaeaa “sonnaortases S20} 22 esieutgmmodepoig denwacesd sundopyCTARELUL WOO (caine) aan a mae OF pene 510 sia Ty Enea Sst, = ETS “ee coma cu amepon oo aS VE 20 ae [seeennk Commins BO See ® (Sina oo ia, Tol 8 SS ashen 10 al Ged SVT Ganesh lois Ge Sto aaa Tae EOS Eiioce ae 3050 aoe y= 55 oe a 0 rg Se 3 os SED = 3 gig, ose Tp anes aE © [Mets mete # oc oo mle #0 mek assor om ad syismusdeg “opsmanssh (enesye | anoe glonsgns op bru! plensoon: 6 ((emim apocdsad {0 OR war afos ope eleep ‘wodp eoronoud ys agedso oimnrang "somercovonied = ‘afasunsey ap yrmorpay ~ seensrmer rnsdnsen wf side amo “cad toson STewmameys wp assige eiupade mcut 185 mInoqwos wena TnOpGOD ¥ op Sedo 2p ne EES FEA omscooe goIpe poy sponse ‘undo op sopiuroyen aje amare o[sr spevsoos moa surlgo “Goud | eoistiace Sdapen I sated fzop funfaso series EcRmp empess 2p siaqpa oy Ee o2ore aqnidoae: ae oe afdtmaxe oe HEROD ne eteorcerm wenofpym wnonm 1 5 “ord FETE As0=8tere] compensstor, dind nestere, prin (Ge sxempiz naloxons sa: IG extazonist 2 morfine, dup8 tenminarea curei de de2- 3.5, MEDICAMENTELE $I ALTE SUBSTANTE DOPANTE * muanipolsi menite #8 modifice pro- belo de unin’. sant nodlnin dopant a spo, Medicine, Modern, eras enelog f‘aud 2an ne mes oyind « nest "yeder =p Sens VISUYA IS JTSLNEWVOIGSN ‘y 1 51 02 “a6 si pepe semen “no see Ss icin on Pan, ooo femme = wag i aw oy many Sasa *r otiod Wear aE Oe Uae ed wat ‘Enbsing st sow minenang WY = nde 7 S861 “Wg “Sy os Seg igor eat Ws Seber Seopasper eenmsens | aL so Sgeoe 9p sn] ounce Reet X sagnooma sora, eepany teas nodose somsposne apo = Tae prion apes yu3t rod 9289 ‘008 ap ats Bt ae nee seunquitpes 29 “aanerss wees, drys cupjaushs oe S0np 328 ‘eis onmpea rom 4 ' sopweunapen = PES “ojamiruoaipase vostans $8 opprapanp ‘wpiqiosgo fed yor wee at un "geese soe uns suqpsdodey aud Pesso opunsjoage sjeoy jeu up 1 zou cmsuonodiy “moot Smoineye sOjLmaNRS era ROeeD ¥ tbmes wsquafio wy oy wonewte bamouTD sour wl iojsaeunoam scaoere tod enqnosesorpino opg0q extsp yaVinoswaoiauyo ViDovOLvd NL OOO WiNEVs snilyuevinouava “re smcrlts puptoaep venoedeed 1 ‘gonnadem Tunued Fimeiiodum amar 2 16 Teen rma “erage 2p aqosszoad rordio ope jeuooens tk fonfoana "ence fame ‘mmseyfog © Ruse zamareaqe wt aeyGS ap 1 soyneders, smoyos wes simeMoopest ay IPHLENLOD “SRINSTEIPE ap Top npaui e nes terSojosod eateourpone oT sum snd coertoep ‘aypams ap sinasoun i AOIDO10LVd IWyLS 37aNn NI 300109 WWHWs STL LVINOLYva. Ssreporie de 60-70% if prin wind, afeo~ | sind eparet, mm mare masur8,atuoci cand tmece pria ficat. Decerece el na gf micgorearh este mult bmp. a 25 de ore (al ‘area di condi. impune prudenfa fa egeste ‘Tiopenald,bacbitrc flosit per anes- teaia generald pe Gotoreste durata foarte scurt a efect ‘Sdipos (bogat in gr2simi, pont care an tezieul are sfinitate mare), pe misura re i sdugeli. la iasuicienta cardiac’, alnamic, Sin’ fa candifiie unui miocard bobay, @ hiper 1 pe cid convatle seca calc intravenoas unde se acum ‘anELOL = hfodificést fiiopatotogice la cordiact care pot influenga reactivitatea tisulard la patologics la ore medleamente aia Saoposianed a pet ae Te aaa Tana RSW En Sa [eas SET) Tearias teen gd | soomcce Se: cae a SR [Oa aT ES poise ‘aces Se em See ae ae alae esa ‘Sea erase pe tt ‘Sova ene 7Jodo geass sfaszuase : “pofom jeredoyay seomcesy wad joumo 25 epaal elberoyaeay yivnse vinaiolinsn ny golpoioovmuy arilyawinounva zs "eeRwol? vas sre 8 wgomme m 0 peearzorey 09 abd “apeeny opgar sed gaaqHoR Tue Pzopioe op aiiozur ob 3p otis oy soeayany juns swore sonoumuoredans 21 18 sateeampeion, ei Le ud oom 33 sarensiurpe 041 nalnsxo op reso Sf aironpuos swoon mem efzazai od ounmsjosoies 8 atdo:oe ear Tresioreq ered RSID 29 sereasteipe ‘date varednuonay “consmae ‘aigsdo ypoew: ad ‘ed ep gsitod 25 yeeatoifony sia sjoaies az8 ay Su ‘og sapanoss rages JOpNCOpEoE Sa egos 1 anne yesna94 yur 30‘rape. xu rebate evitate in prezeafa insuficieapt re iscal ecm ages Sears epi Te ae» pial te ‘isin aka Baas weal | {200 000 wu. cuprind Tedusl, dar reporta dine aaularea cafonulsi ‘restora intervalulaé tute doze le 12 ore la 2 compris Gontsindics chimioterapicul. igoxiaa esto glicozidd tonicardiect cere 26 climind reas, nemodiical® fa pro- Sonic de circa 2/3 fi cae ero ua indicewosade + waite: Ba) 2 3 FE a ores | _ ose [am] ina) Raa eae See yeu ejaspa "F sveojpujeruos june nes OTerop FONEIONT OU 9109 spmaemeMpETY ree taza 28 emo sjomsuroypem anead “pay “to (sous =p atlony ty ‘aBoqosud je UNSTES Image ap nes aN esise}2 2p atomny of sofazop eadnae nm tap area ‘suaiSouoa. year ‘peas HssiogseY Ys cope ¥ soaieo yop un vamp] (PNG sem Jowrundssiog sy g8 dig “en wissss-guempom gener giesegnact seupoa Bf s7soi0y 220g “THeyooten ea ‘etaaiegne vam oa sompo:d 25 nn 2p spe ‘one! 208 Tap ‘eprmedasoqsclimind im proporie mare, aeschimbate, oon angles @ ace cm fn cazal vitaminet D spare o insuicienit ‘Modifier ficlopatologice fn tnsuficienfa renal, eare pot influente proprictiile farmacodinarsice 31 toxicolagice ale medicamentelor Teas Enger pares Bescon "la Sein cava Taga vases, | aloe esc igs aoa cry Tita Sac, Fanoa ls mae Se) wlocasea, ania] as Ze eco ‘uncon pata al Fae aanme Oa naa aaa ae a mas | 184 sudt eficactatea oft dorsle mici, foaomencle de Glen Risoul eresout de hiperkaliemis fc si Remoragile Is ecidul SESE cvteren spiroolasaci, temter- salle sunt mal feovere fa fas Roja gf alr, churetiee care wefia por renal fice antes 8.3, PARTICULARITATILE ficient rene FARMACOLOGICE IN ets esa de seni de potas. Sut” AFECTIUNILE TRACTULUL curasizaat depolerizent, peal DIGESTIV pecuroolinesteraze (6 stutis parcalart sto oon madion rmentelor aniee pore rnici, care WbOHe up Setccle mercurnle (pot provoce necrozé na (poate saetoxilurs renal "Prantl intestinal accelerat tm ente- = ucts acute Gisiatens’ sbeobfia. Feno- ‘eutfes datoait acfonl lor de ssldsre & penal poste # semnificativ cliaic penta venti Oi, rene, de creslere & uedicaientle pofia ligosolubile — butl- Catabolism! prota. epelamint, propaatsint, ncostigsmint rane Sentt ets grind tot- Ge cee gf tm mod normal se absorb I cua simone pour cle organe. Aste, miiat § itegal, De asemcnss, forméle Sosteatle clotoxice ia enitiotcle emise : Sheondice qi la acidul eucraic sont mai de : reparatele Recreate le wemic, fenoteizele 22 Teplice provoact axcod s doorle obi ‘omprimate are 0 biodixponibil- Sais i inegall, se absoasbe mai "enultranalt. gastro saa vapid “Siniroamele obseruceive 1a nivel 85 185sat euseou reese geesaou 3 2289 {018} sp 25E ed ‘syerteueonpens armifoe YOSEF seus wot sod TONES eho rOLvasH arnniloaay 30100100 vHEVS sulyuvinouava Ys 109 wifojorasoydms preaueste 16 weap sp wuss qos mise JQneE yaeaaqorey aro wou 3p 729 38 aod ~ pt ans ep sniea0x9 mon zane op IMOEUEIS © pelafzove at ee ‘sraseeid od gomaae)$ orodacen@ oy ~Wppols sp panto Wie o YATE ATSOSTP TOTOpat induce 0 si de enzime microzomale hepatice, metabo ‘cporaea hepat eee oe oregte Fssul tox Cpurets fa proporils mare de clue Acat, 2 flitua de cele eu tropism toxic be rival prin conjugee le aivelal cet ee deficiert in insuficieals Tape xiv Ccateva medicaments care pot provoce ress toxice lo epael | areeebad seston Stecanismnl gesstora Tria seco jaa Gotennoe Tie Bie aaa ane gga NST SSIS He oe agi Wpoicala wie [ad wee est gon a Go Som ID ‘Fiona ornate jipaciaide coos —_‘[opones bape ea fades asniag ESAT [ipa Ses GuREOTES) O jaa teince plasmstice. Coneceativ concentrais fanguiai creste gi, pemim dozele mari, cee ml tice pot avea reper fi se Axeaz’ In propo matice, Erect sie acs fxts malt grelungit ‘Preduisooul tnde ot reallzeze aivelust ‘msi mel insnfichene parece, hipoalbaminemie ~ Sefece eB creased pro ust peo este Sing; eceste amibitice tind 3B se aow 189sempeceminy uspo area so “arspennys emp ASVOLNANVOIGAIN yumm sn op aundsp aro ‘yasspour a aTNALLOWHALNI “9. apew. XLVE (esos) 6.4, INCOMPATIBILITATILE En eS Bin mead = oe mane Sails, etude, baie, opie, pecomecral, aperimentate, do Ia anime 62:1, INTERACTIUNILE ASUPRA ; PROCESULUI DE ABSORSTIEser Hb. 1 eosroose ‘sj orm sowon por eee snefnfsoaoyfas Sermspauayip 29 FeO 2 warensiunnpe gorD eenoegE yronfom o] eNO “epee sue usp i a om ‘9p tmusse03d sssam03p ssmussnoo ses nereld 2 poupe poe ‘mes wary goronaid ‘serapHSe bs FamnfarD jaoderparg wamnoiypout aja iodswp ato od ayu=uR-neagd ia domenil eandfovascular efit, protongind efestl 1o- vovizeerh dieses Deplasarea de pe procebels plasmatice 1e rea proce de epurare « glicozid ‘seeea, aioiaistare de ch suprevegherce bi = Geren dozel de digoxin ‘hind. dlspost Se edminstenat Gmp fedelungst. ABELL XLV 1 fi relevante lini, datorite deplasieit Weuntlsde Legare Usulard, cn eresterca SF sperices riseul toxle 6.2. INTERACTIUNILE ASUPRA METABOLIZARIL MEDICAMENTELOR smedicementoese Ia nive-ABELL 1 censhmatice, care fea eflesciati Citeva exemple de pot f releyante prin s ABELOL LE ‘modifiearea ellmingrit eracjunl eredicementonse prig fnare, care pot ft Felevante fai Trine eed caine aaa Tim imide come Faxon Teves ant, ae, rei fae Se = oo Sr SS aaariae ager a Meadconante care se eiinarss | Matconante 2 corel 7 Be sige wa YC, Tin iofueantsiok, prcke- Feaivi n ca 6.24. INTERACTIUNILE ASUPRA EXCAETIE! URINARE cl, seo sae ene = pen: ‘3 peotra un pH al ail is § qi pevie 30%, fad pial este 5 Dicicamcatele sab seide se elimintez g0190701Z140WOLYNY aVaLSIS HONN IM3AIN 7 'BOIWWNIGOOVNY sunsilovesini zee Suposeo oo 1p jnaipou eaqensisp seo 3c soyodsmen, isueacar yfejooe gezsquoyq 20200099 “ona, oe enn a oo wn pug “um ayy ty 38 rots Wap nto 1rtowfoe omo shansgns 7 ¥ narsoosy uvinosion, ‘sommumsrggue ated (earEe ynexdoad bd euqeuad “ouy 98 sortssuapeeg sim aja = “qordone INU ase oqo, ma oaja page Bune “eH spied npr 2] fajstes 2p atfoony ay 2p und Z soj20 © negeig “sseoxzmadesie9 aside ‘opeetsqns agrseds pracrqeodeyre ty 200 ontoe of Be Bag “erence otuviigoownuvs Niguo 3a 3svoLNaNyoiaH ‘sTINniLoveaLNI “ee veqmorcey zema sofoqg@t espos ep seeogmoia ep eases “MSDE "JARS BELO} qe EmeQU sea) op& {TABELIL UT (ona) cc. eazd PaS trot sb. ae oct inh, coutioue AV 6 inamie, fim oe miowich re. sma (ia mipsatens) ©) fh Se Suess is 1 2 taco, ato SS, pelcoenis cu poet vse ru tamstpene | 3 teerd 902 oi eee | RISE SH cp von 29 sated “yogoou Ie apis J “Sows Seatpost aaa | soni 2 pear #00 a Gao | seats op seemed 2 | nn a taaeHE z Gmina 1 Tae‘TsRB10. Ut (conse) ot ext (1) — ab, metab pea denis + cone, usm, oatamani i Sa See cme [cre cm net = eosin 7 ios tence 1 Been i ett eat fe Brees + eater te geet ope wee Scar SEE Se pte te este: vee 4 depeimante exarie coca te. depetaast conte CE ectmal statin 4 SHEETS sake oe sais SRE hase, encngiae cafes isaore smemen 2 Toman vet Sa ae)ABELL 11 contanee) {ABELL it (one) Pesan taempuase onl, onacopat peed Flssee Shae eae oni =) Pr ins geann ts pe ee i be ies. eee 2 poke, Si wclhetenine Qa Boca, bose Shaped anion sera seme ace(spore 9) Spas oe A ‘Gounod 1 aaaABELUL LI (onus) | __TABELL 1 (eons) 4 op oi mou tose at scp ye esate 4 FS Sesto, 1 Hoe mate a tim so) J a chic Flac saan: pest (4 meats) sa okra ce Pe scezonSp 8b semen aot eq ‘aed a0 ‘Gener aa aaasavE‘= de exemplu ond ‘cetarool $40 i snalgesic, de sau peoira ant (nl #e eoomandé ef administra sk s2 Ta eel pia o orf Saints eau 3 ore = dap mast. Ta € 64. INTERACTIUNILE MEDICAMENTE-BAUTURI ALCOOLICE $I MEDICAMENTE-ALIMENTE sau produse latte, care sant bogate 2 sbiorb: 6.4.1, INTERACTIUNILE MEDICAMENTE-BAUTURI ALCOOLICE 042, INTERACTIUNLE dacine gt exoxacins). Absorb flerdl me MEDIGAMENTE-ALIMENTE dlcamentos este micgoratt de eftre uncle ‘componente aie alimeatelor ~ tanin, ca Gin, protine ia exses. Levadopa se ab- Souike mai pois cind ae adsiaistesat cu o diets boss In protene, espectiy feni- feleclat, eauinoseld cu care fot fa com- 5 veghere telor fn stomac Gimp de 2-3 ore face w fgusttiniestinale) tsi, dupa a1, evi- mm 220ewe wane ‘ans “ups ‘mesa imazapig TO -aBan wy Rog {eae Seay oh we Samumojsten ye o suse sojsuemopem © pojuents > EEDI|NUD U8 apoguion op dopereanrd oncassey opemisueoipP Poimnize wg rooyyduy sumo sioongat tod ayucmsye wy emtfoes aprguimny “im mid teipRes eaptoN® Fier nega fue) 2p "oiy solace e'ytum Hud semanas papofom See “im [wut safes swod = song 8 suo, “ade no ~ eos mem TRY Te se eerie. boned gas oa 8 oom) pp extnemnie, uumct soxper Genemane. atc: ors RGINOONpIT yeweARICS oF ‘sengigo od wpsnguioa wud) mgd | goer pamitoe jnaiey Tenojeesn G0 9p svow says semeu> © to oR amp Hpvttord nw snenuayo aay jg Mis nkreemopea tommy SOUS Oia) (as 3 sponimesé sp suxy op atu peHoaied emmeune opment 2p sine. 3 uy atefoq yt OF-og ap aise ayenzn ejszop mraad smnailge wyfenusou0> “(pr fajendaid need a1 ¢) suensiemupe 9 op alan ine erfeqeosoo Freee 222), fad ot pny “quid ido oduan sjetocl SonweRos Tsa0e FHT ado sys no varenormacide praersOHeS rape wp ames OZ Wop ome Ta oj ‘onuneso dopa oe 2e0 aieoup “puase sumaporoual iemmudoud aycut de miocard, daci na exist contain ica Asocieree ex trombolitice intrave~ toe Gajectate fa primele ore ale infarct ff semaclor de isehemie pe electocandio- i Numlnl erizelor Rony een J angine de piept Se adminis. ‘tesa ra, fncepind en doze mist ~ 10 mg Ge 3 onl - gi ecosednd progresiv pind la pana Asecierea cu alte categorit de medies- Insufiioge renslt, wade ta inmficicaye carne 3 te feo 6 periosdi eupriash tou 3 sia miocerdic este att ria ciminuares Cuyului sanguin hepatic. Bradicardin marcedi (cub SO/minu) gi blo feotl ps (ele beta edrenergice la bolnevi on infarct ABELL LX Baar | Foros licence. In conde tratamentahe cro- tear inijal fic, beta blocentsle pot provoce suodifi- met cu 50 mg oral de 1 or/s, eresoind tatea profil lipproteinslor plasmatice Ja 100 mg de 2 ori Soa | Nope a3 338 335aap ea: apn pce emeongy apm as Joyal» aeaeny com opie aR © TRIE tp PEE gy 4 seen sors rane, ope gern mE tegen ne aia sues AV p> le TS sasha ena satis Fae > ace eee ajo etek Jor i Smpiedie& spasmul arterial corona exgommezing, Ia angina cro- isthe Coles. Mosioa anak” Mii satpenense™, 338We 1 2 sonst eooosanes, Wf eam Au ogy og (umedessa enstamps wom 188 oy gaHBHE no weUeg Ym yopsedsores wmgue UP weoqpay as, “a coojamzaso|s impo sotacooise resoupaco i pcs ped sump a selon dase some ‘HUB “(coussenoy peesooley 26 POE “puood ‘pioyes uoqes uadioonoug “pcndoion) yogareder> 4 “Sem ‘aaqajeo yum oymanoayy yest 300 nibeoy “yimuodas ong [esas frau of satay sprzanp manos ~ 5 J T ad meanttpete ~ se — armory a : 2 Sion ] z i 2 a || tora “I Son | SS [mee | Se | cay | eam PIE Jopreues os suNoy] SpoMESIpM OPH aye TwUPEHM SAL snot trav i | sap ~ gopedeg aremjoqnam ted psinds ‘mmenoag, Aes i sincol) “isopan cuomoNsy SIV G55) noKEHOHD our ‘aurea 2 gosnig sosido Edn ‘oses yuHBus 9 Haro BL NCIS musmoue “Tmuetreoypem ypHyenvos no symtosied v| OPN y 200d Qa “ase appr sil guseaoy sezop oso1ou “greaynmnf sise NE Yenyuneed "pow‘Verapamil re 0 biodispont sdmiaistriit sugar. Dozele necesare rapetgl Dov fetiyile farmacocinetice ale principalelor blocante ale canalelor calciuiui Verspanil | _Dildazen $50 > % Ta 30 3 ‘pai, Fal 5 Prope + 15 noverapani} larespand (0%wee ‘ toms ARRON ope ea ms ret op) op sod jeu axfors pmsseen 5p UU anar stop no swords ee 2 nuyigo ne-s oxsar> yoauiean =p TEP omen mado oy pmedezma 2p yee REDE facto wy Yoeojtind Mesteenay 2p yet ‘9pm | ps usage oem sept yan sara soy Jeeeriop oe en cepap 3e= Seen aofann 209 ppmmcoe STOP snueAsp ED soeyEUED LOPE 2p asGeNNENUENRA MFT BANE toox aareeR| * fn angina vasospastici. primente ale nimi, 10.4, ALTE ANTIANGINOASE Amiodarona (aniedarone, canilor, bergice. ‘Farmacocizetics emiodaronei este e+ yacterizald printr-on rronzit fim i o acumulare Gepsa IWorul dine eport gt eliminare 40 siabi- legte dupi cicea o hint de uacament. Tim pl de fnjomatatve ese de 25-52 alle (cu * Capt Asta 346 _. 300 mg de 3 os, apol cfs 200-400 mgs + ecaptarea; de 26 at se edutiaisteazB, ca ant- anginos, pe cal oral, primele 8 le cite 4, 5 alle to fiecare siptimiad. Este indi- cath fn angina or tail Bt gf ponevea la soar, Lion Fipiisetal de tratament rispuasal Ta efor diminceank. Blectl Yor Sniagoniem compedty cu ionii de ealeiu ‘trougsler netezi vascular. Bfi- acitetca in angise pootorla este mode fi, Se administeacd ora, ote 60 mg de ‘Porili Ge Sncepe on doze mai miei). RRedsfle adverse sunt fae: fbn it 5 Ga 3 prize). fa flee infarc terspentics To angina tits conehi- dovedité ou eeritudibe ‘Se sdminiseazé oral, cite 150 mg de ania de dared & vee ease pot f allatste miedicameatos. injecteati intravenos Tents pundsmaoal ae prope easagre- clic 40 mg de 2-8 onl stu pesfure, 400 meta ibsoarbe bine din Re fn lest gi elimi-aalat cee ede mkamitajre intrevenoast rapidi posto fi canzk de wep ote ge admiaisteadd orl, doza obig- Bpotensione arterial jie adverse sunt rare, S-au seat~ MEDIGAMENTE ANTIANGINOASE INREGISTRATE IN ROMANIA Tho Mack (Mack, Germanis), spray 125 mgldoa8, cpr. 20 mg, 49 me, 60 mg (reterd) ° nonis (Oren, Fiend), ops. 20 23. Cord, Corait opr ret 40 mg Pec Romanie, Dexsoo, Ise, Isosorb retard Zéravje, Yugoslavia), voagyes 10 mg, 20 mg, ope net 40 mg. opt. 20 7 Peo round (Pbarwacia, ‘TBesorbld (Aatibitice, Roms), cpt ‘oe ee 2 mg 10 me. 20 mg. ee "Gencve,, — Issorbid dnivar (Laburmed, Romizis), 8 ‘pr. 10 3g. Cts Chemical, see), Isosorbide dinate (EIPICO, Esp), pe. 5 mg, 10 mgbre 32 002 Se og may ade “eusep, silo “(ersancig “VaWS) euourps03 Sa 092 ado Cemmmey “Tame Rucwmponey Peosoponey oorepoguy ssvoursacunie ary wz fe 5 go ort 0 3 oF "any '3do pam “woWD) pundion, ae og Buoy as Cepmmey unpang nny) faery AO “de Bug sto (emeuoy OC % or stern ~ anew pesinay, —VARED Pre apiog “ding i wb emntan “o8—) xepepico Mi go og tr ado ha Gy ate ermal) pie more mepy my ema ERISOAY LoTINT Ceomy weusnt inp wong buon, 8 do “(epaiy “uumpry) sidiecnoug "Bar 0g wo (id Sly) wore donot = sw ot Sm of % ado “(enepso8ing “aljsep2) sma 3 Bm pg var sd Xda “(ermopooeyg “poOTeTY) uaRiPIY “Geant uexeg) ys or eudieoay aaron Ba ¢ Jar ad “memes aay Su gf “Bu g alo WHS) Pevies opis oc db “RRL GET 8 Mppe AD OF eRHOS ‘8a of Bar € x “Oyng “naRE) armuoye Padeopury ImimP[ JopeUED ye UEDA“ 1 gf 5 sg ado Yerepeon ‘pouteoy) ve Bar OF ‘(ommmoy! samaoy) Bu 08 “roy “9 ‘wonmnaowaugd aeiv) emmoypir FYB { =u “Sa 08 “Foy at OF TS ake (OBEY "eSOET-ISD rove Proueadons fur do por ‘soporg) a on 2 opt “tm op abs eh “aso lone mare ‘ ogg “no “(elanig ‘suoy ouaqneg se0y) son97= . 210th Su | ado “efong “opmng) wlowepuny 3a of do “ormmmusg “gary OF ave ‘don orery “But og do 0 ‘EARMEEY 19) JD uoK gpptomeary epemeaoy soiRrouespe-eeg 2ques0ng, Bu og “3d “emu “wmegg se) Buoqoney Ba 02 slo “omopmey“eydas2y) uo ouuaen a {ups (emp “pemyy) werogjaty Sat $2 8 ‘Gepap ‘eam pseu ‘0 gz vat ‘Mo rope sp Saade ‘aR reg re 1/8 ¢ of sb "(oremaing “eges0p) sat xo ‘Bu op Bug ido “eos “wox0) US 09 ‘Op ‘02 puoreuoyy fax gp “Bar gz ido “(renmand ‘suea 28g 21900) sooty owoyy “aa ors alo “Bu op iD 2840) sedep on owe oON OHO sumo pigionony iw ado emguoy ‘poman) apomuoy, Str gp "tng do (rtm, ‘suc eq 22900) pris sooKoyy 3 oF iP eas std) ev 9004)BIBLIOGRAFIE SELECTIVA Tin, Now Yor, 196 Rudurrd J. ~ Phen 35080s stesso someon pale 5 em pf 84 mo eeepc some W sue sme SP ES Sap Ma ~ aE fA cogs gonsuseyd wfens20u09, eed oad of Form wu aod a SN ers ojdeosiosu too nd conte aiounsucdouucig ~ (20 24 bit qicmnl [Bie (OTROS PABST inepco) epeateo esnay myo plea sp yosoise oxduraxe op ‘sfansqas 2p eareyeges wid YVNOWINd ININVLOVAHNS ‘ATELNWHOLOSdXS IS FTSAISMLILNY “8b65 agin. Volumal aparent de dis- kg fer titagul de ang de 3-4 ori. Poste 6 carl mat ‘nibd marin, care este robeil respon sill de efeciul analgesic pot provoca broahospa Uitonith elibeaci dei ful deprimant central. Lat ‘mai mari de 03 mglkg a spimorphine, codstnne, iyrocadone, d- ‘od rin sioteas, 20 propria asemingioae codeine. Riel Scgendenje! este ceva mal mare pentru Dozele wile eant de 25 Decele mazi pat proveca ussciuuce gun, pam bas Go cha, cpl ea administrarca de - ate. * Sireagd gi somacleage. Nu provoacé Pentosiverina (pentoxyerine,carbeto- practic dependeayt at fenal (tevopropoxyphens), Tarudit cu mstadona, are de opioide. Are progriett gl ese slab bronbodiatetoae. Se administeezh or racic scfuae 50 mg dimineas sh seara. La copii s© pol ‘pentty ceime- injroduee supozitoare coafiuéad 20 mg, espe 8 mg i cl sugar (ou se ads-- Sind de 40 mg de 2-3 ris (Comprimste ikea la drste mai aici de 4 Juni). sau capsule retard ated att deprimit inhibin componea- fea, pentru preparatle retard, 50mg rift; dozele recoman congestie nezal, diaee, erupii utanate, 1) dorer-retard, poseladine), un compue de sintexB fi Firudize ou opicidele gi eathistaminicele, 48.2. EXPECTORANTELE Expectorantele sunt substanje care fo- vorizeard expostoraia, crescénd cantaces Ore c-e frets Ao a an-o-on anu Hs = tr ‘ip, 105 ~ Suc cml» wer meicanet eiveas (si wnepoinyie) ores 2p pepe aud se] sacessjodsa ap pau? pseooe TE Co-s0'0 =p e2op af ‘quo of sepydea ‘symm ref un we etppoy ‘qumylod =p aL} gas f20 2 3p) 219 9 samoay af BSE QE =p wise ouopendsor sfeamgasm my 1 propwe =p oud unm sjozoq, eaeys aise gonnadeis aERs w NUS aMGaN HOME sp LAE vereyoeays “omesoadr> ruled aiLEyIp -oID Hosp wf eR wy ~ gleoeTmOME ‘9 eponeov ous‘ tn op ST etn we ato a emer dung oiase® ploerqown no p> Tes ben op @ Sahaape ye p> ION ‘eed woosost ted aroun op SHARS "BIE §-> 2p BO OOE 9P PEE 17E sda docs ty sfepueeioaal 2220p “f2 1 36 BLOT 9p BIRO Soup sp aouop~ mie soy 2 au ee Sys mtg nes pinged sanasrapy us plead onme vo genase? alot + ep weneo y yod aueicyadas vo sysop syeuly “porbuougoryou oyfecoecindy 0 amyf case wo expe sizaneus oqoqued putoyey fsnonar mmmcen © owe 4p sarERU Nevesopoodee wtizodaos wayere i fn, SLNYINWISOLguORS SIINVUOLOaaa “Tze “iu 3 voseoyipnmy to "pseoonas apenas dcp movant sudeeo weap ouHl? od es minstonmeiuscodmes wp io mp rike ‘jruse vouaslaws no “aorbuougoryai 40 fat nes qe “Buco syeedaad op area aur uA, ‘aoe feusip aud jnimona "sm ‘2p jynxoyss konpa 785} oFoupyy op lund “eyeey sep ges ho} “somo Emaydej — prog8et. 9p md ‘uueyp = suansrat md ReETIERS “NCI 18 sou Oy grBoq amIpRY wafer OnE) ~eyooigrongbaye Sg © “IEEE HP “aus no ‘ogsqoj Ts efamiooadig j obey REFAROBOTPEE BOSGE 38) HOS| \ i de evcal serie de compustolci gi trembexins . ‘Benzoe, 6 rigin& cxtrash din. Sorax wen de acid benzo, este 9 cleorsint onfindad fo principal ei atop foi legitad - § = 8 ~ fol ms fF fregmentale de mucoproteind {i Bronbopulmacare, cronice obs jredemisent an ‘foes pe care le fluidic Hi core 48.2.2.1. Mucolticete saa mucoraglawoarele ac- file de ageguva macromolecuelor p foghicidie care formesth scbeletal ma- cusulti, 2 ‘consecutiv. ‘oguraree expect ‘ip. 106 Deacon ponents ner neta, le MEAN PEM ele ucts cic Catena) Mesva (mistabron, mistabronco, muco- e sedi, posi parapetanohl Doz sat pin gruparea prin grupares sulfonic® pe Pe jh enpectoneze (ea fia de wzen). Do ingicatilor ca te peste prof oragice produsd de ‘eofesfamica. Ea se Gali. Deesle recomandate sunt de 0.75 8 de 3 onla. Provosct uncon greafd ea wotliald » antiner ‘is Seeasd indicaje se edministeazt ioe GH C008 Nat AS ~ Cty Hig 85” by f-g-cHs 7 f Acotstird “ereO acu Cy iy Oy te Brass ‘Amie (i. 107 = Svcs chic # ner epee moss sisors orp “rojas wapendeo © $f yoga ‘arcsquoaq Te f0q ins 2p sndaraa en “(rupu2ame: ‘jexoiquio) yajoxoaquy rime “Yoong nideisx> =p) oad m0 stoma To FEPSNSTREPE = PED oacty ‘ao ‘opjottoqutzersp PEE 9p omomet TapuoTEn md poy qUmmaeby swtompdogon ania uyNownd ThiNviovauns ‘est ‘2.08 H meeTEoR: “yEneaT gt afijes o-meIp ifotamse ap eammsTanape sos 2995 ade no ows run exlseap Ra 2p sojvodea wamejeya: gpeeamooar 2g ‘soieoso awvowmdequoig mniore aay ‘yen aotfoouy selsa® BOUIP ‘8 geal‘Surfacantal est indicat pentrt wrata~ menue curaniv si profilasia sbrdromatat EDICAMENTE ANTITUSIVE §I EXPECTORANTE INREGISTRATE IN ROMANIA lefedanc ‘Golmonsin (Biofem, Ros int 5 Coseind Casein phosphate Medimger, Unga, cpr. 15 38 318 respiruoric. La nc Pedneipale racic adverst soit Tussomag. Codsinmopfen (CT Asznci- Brow 11% (fos inon (Bockrnger Ing, Germenis), ‘Brag, gl, iat. 8 mg/6 ral tibotice, Romania) Dextrometorfa akindss (Pour, sirop 01%, 8 mg Brombexin (Lab. Domenii, Roma! i confirma radiologic tnecetied. Doza vasist8 cu pre- brombirat-(Biofsem, Ro: Bromhexin (Lab. Helecr, Masistra, ‘Labormed, Romasie) epr. & mg . Romtais), _Bromhesin Fablbere List, Germanit) — med, Rominit), 6 mI Frans), gelle 12 mg * Bromhexin 8, 10 BC (Berlinchemie, ‘Germeais), sol iat 8 mglS tl, 10 mal5 mi ‘8 (Phare Meusebsch, momar greatete micd gi esie ermoalatl ta uncle ‘ceiliceind (CC-200 (exal Pharma, Germenis), ops 200 mg, cpr. ef. 200 mg Acesplelsein 100, 260 yon CT (CT ‘Aerasimitel, Gorm Zn GION Glens, Yugosla- op 125 sig! ‘Cong Toner Pharma, Germ fale sep 100 mg, 200 9, 0 mgr pr rel 600 me Gueifencana anbroxol “Heed (Bicfera, Romine), sol int “Ambon Speier, rein, 10 goo mk stop 2 9100 oo i? coed ‘Trecid (Sicomed, Rominis), opr. Codetnt foxes Cabormed, Remisie) cor. 13 1S Cocina fesforic& (Lab. Magistee st ‘Sintoferm, Romisia), epe. 15 mg Caden’ fesforc8-EEL (Bicesl, Roma aia), cpr. 15 mg Farmacod (Formacom, Romtiia), 1s mg Fouls de codeind (Laurmed, Romtais), cpr 15 mE Say 30 mgs aYOLLVINLSVILNY WIivoIdal “31 YAUOSTaS 31vuDoneiaSp Heese Sp spuidep summa ep pucsesey oud cpmedo inden rene oyeqmtg STANINVLIA “82le sat bine euporiate in doze jee, Supradozarea poste ‘severe fo oszal vitamiaelor ipo- valburart soluble. 28.1, VITAMINELE HIDROSOLUBILE 590 ‘prin urn, fa majoritte sub (SST id£59 ‘epend:y MPI Belesop isd ye mogeios men satop coe se ft jay yoqeeut soma easrmso} x{ “oy Mp ommq qivege es Og SouIUTCNA syeicore yopie © of gf easyduos ap sess sua FOREHD EMIERG Fed Ad neee ne notng ‘ow, poo oon S Ty sunauedooy nooo" ottoy 9 : Nooo ho-to-u-z16- Bano he : y Fanca - = x spuumunaony ST Oy ee te eg ce nolD-=¥ rumpus HOT ‘On ewvagooy : i oAo® nt s. fe ho rhonipaprip tio -oto-sol Ql oo WO HO. Ho 9 Sg vores TsEZoU men eHeonrINg BEd yeotdicw ap aqrosge 2 Syfers capsionl uy ys0q wrinneur) 7 oot ep rant as o ated Sar ‘mupHd neous no ndaxoa fapendne 8g aojemqueys. Indus a WNINLIN) vNIXOGIuid “eT ez ‘rvousaenuy nes amenosnusenH: geoyoge & ‘usadscomplensl B. Efi vareiturile de 3 ites piridoxinei este metabolizat Ya cea mei mare parte, ala de ire formiad wn derivat N-metilt, pentra ‘Gousle foarte mast epurares se face pre- trie asocierea de preparat= coali- st minerale echilibrate. ,- Dack spunsul au este adecvat se reco- sandé asocierea de tiamind,riboflevink gi Piridoxind Sn doze farmecclosice. de eguld, bine super dinitrate prelungit fast pravoce nlburdri newrolog! jomene de nevi hares coenzimelor corespunzdtoare, fe s7ti Geosrece este bine suportatl Acid meamvtsaau plerdend Winare cxecsive sicctinie. provosel frecveat congest fcidulei nicotine (pelagrd secundart). In def opt Gfuaminel poate éeclanga un sindrom de chiar {a dozele relativ entry coresterea defcitulsi ‘genetics carscerizale P ul ‘gekmald 4 unor enzime Saree perferict 2 dopes, micgorandi-t © Rcacitalea fn parkinsonism. roamelor de milabsortgic $i le 28.1.5. BIOTINA $I ACIDUL PAN- hipertiroiieni, Je prezenta TOTENIC carcino, fa aminoscidurit $i 28.1.4, ACIDUL NICOTINIC $1 NICO- TINAMIDA (VITAMINA PP) saga “Anumite medicaments ~ ikoniezido, cieloserina, Rdralazirele, penicilaina — Sdniniate timp fodelungat, pot B cauxa ‘Acidul nicotinie ftconte ‘ fname, iacin fese.apreciat In 0,1-0,3 mg, centtats ‘coprnad fa aliments ‘Biotin serveste dropt coenzimi ta .procesele de carboxdare (a piruvatll st Einar forme asl de CoA), avdnd un rol fe manifestt print erupiic ct pe piclea eapust la luring (nooale orle pot Fenomene de bipoviaminows Bg, d= obi- forisnt ix metabolismil glicidic si flips In mod esters. completcard nevaln de vitamind PP fo- = 60 mg de aminoacid -exflintvs,alpecic,gloitatofied biper- 2, an0- ile pentru respirala. ti ‘doulor obigeuite acidul nicotinic ‘Nicotinamide cate mai avantajoast‘ad ony 28 vores “CY gL ep ampE un ar ce Hj apundsaian 20 ¥220) BHA OF -pRqwarE AHOFTEII? 0“ CHIMION.A (0 wnuwrwin) oIgHOOSY TNMIOV “STE 9 geetieapias Smo roe aca “asoese yoda ¥ nnaed og op Sad | | | | | yeaa [apEE ase sed “ogee vo 38 gioqungesca pag} ns “genar 2722 jode ‘yursepd uy aysarBaad 2pe2s 100K : eosa ais afouny sop ¥ RoMod ZO}\ ek a acesior fonoment 20 ext cunos- acid fe, Eat produs gt de bacteie n> ek. festaale, de asemence este probebil si- vAeidulaseorbic ests de reguld bine Drgeniem. Forneszi fn fesutun Dosele excesive, edministrate pot faveriaa formarea de cal Drie mrirea exorefiel de oxe- ul presungit est sopti= oe minore de elor, Inodital trifosfasal eliberat din fos- fnortolal nemmbrener fune{ioxese fe cotnpoxiia ipoproteinelor plasmstice gi Ire iano ele proveie Ff alcool ou deficit de folet. 28.1.7. INOZITOLUL $1 CARNITINA Sina; scfoneard do ase Se eesiere peatre difeie tpur de cesta. ina, ca face parte din aceeagh servine indeosebi ia metsbel Imitocoudri, unde Dolizai. Carnitine favorizeeat, ben, mcabolizaren serch 3 pte Togitetat allmeatar ~ sport este de cinea 1 g/t provine din vegetale, unde fe gtsesle sub fonmk de hewaforfat sau dstiva, Tn confi HO on Ho: on idglor rege vileza procesulut de fosfoilare oxi Seiden (oryy-or-gr-cs-c00 be Levocarniing i evoosmiinel 698 +. 28.2, VITAMINELE LIPOSOLUBILE ‘Aceasth grupk cupsinde vitamincle Ay Indebongat, fate, indeoeebi tn feat. Accasta explicd condi de carenis, sinptomele (oper aarala (Guph ‘works digestive — grea, vom, durest uvinale, diets; Ia dozele mer posts fa um misos earacteile al compli rea produstlui racemic produce une- exalt Rretinot =~ CHZOH > retinal fe— CHO fod retinaie = 2 COOH ratinoin) ‘lg. 146 ~ Sunotace chimied a vieminelos A TVitanion K site prevent fn esptoil “Madicaa bamonatct 68ny puymmnds souioads une emit TE a ayoAaap se ‘ito sowdeoeu joruniod on REWER ROTO Tinea ¢ =p emoep ty oe dead of isno¥s: ase fa Seong] "F2rao2=p sousep oF eR "uy. eae HOUOH! 25 TeouR 5 aprcitess oyuce Umis sso189 wLid 2300 9s aise Seanpou Asem [ eeeuey Ser site ote oh, gets | “b> % Pan | stein —) — pats if 5 “Herne ots omg ap Imoehar Fes sfmaxe 5 sa © snodap '8/8" coe #8 oot nm ssuudeo “uem enteoza® Sd up eine cp 2 POND PICOMfulsed, fibroze chistic8, cl bstrciia bilan ete, Cio turd procesul de éepe joue febrile $ in be fagh de wansformdrle experimental prt Ge proteint ansportoare ‘Fenomencle clinice ale hipovitami- * gozei apar atunel cid concentra plas- 5 ue! fervor x hiperkaratou! foliculard. Tra Tamental ov preparate de vitamin A tnis- 1-2 tile; lextnile oou- ate incep sf regreseze dup6 sasoxidante itamine A favorkzeout procesele ima de apérare cninfeyions’. Cereals prezintd © absorbie ws frisimilor, espectiv @ testa. In hipoviterinozs Sack doze de 100 000 ui. GO mg) sa ‘dmministerea orld ete 200 000 wiles timp de 2 alle. La nevoie, © poate 1 tan 1-2 siptimdsi fa sindromul de bsorbfie este descori necesar® su rmentarea 4 25 000-50 000 wii. fe revomandd iajetares intemiscolaré a” digi decaf slimext asain co mal- 28.22. VITAMINA D $1 COMPUSIL stares ral» 200 00 ui inuoIT i tants in econom ero, caleifedicl, ‘um analog de yal Cy-Cyo dia ine B a} mucleulut tu fommazea de colecalciferol ‘precursor, conju fn ormesté prin ira- (@ usitate international Supradozarea vitamiet A determin 0005 ug colecalifeeD. Is fenomene toxlce de hiperviamincet Ria- Refioadn de cregere, ca si in timpul sere ul ese mate clad se adminisueezk ailic, ili gal elptiit este, nesesel Wo spot fexogen misi mare in jural « 400 wit fo condiile unet expuneri insufictente 1s sosre este de aemenca nevole de un ples de vitumind din afar, care depigets can- ‘| ou bige . Ja gravide, pot ff cautl de malformatt coagenitale, Retlaolii de sinterd pow tn rise tevatogen mare. *Capielel -edioaya demote"soe oe sind pmowioy 2 ssopouamy my green jem 2p so sa eomemnioy “Gury ejooe "HQ OL emmNOfem oy “coe 36 GQ BENE sofor auras, -o590 Up valremgond bud 1 “pups ‘20yx0) slajsuce a "4D 2y Sf cess fone my sony oe vomeed ape © 2p HeFot EDS Que ous 24 ups my aayOMR OEE -nifoe ne menaiogouy 8 oomue sfonee + 1 Foduowfou! & 3] RUaRES ao GPE eH apodep op 16 sieojnons omioy me “wojny sone 20 Hfadinue sun oUNND eam ~ oer “Fat ones ya. Joun ezdnse pare = Lied ao oe ae emer i ; catsmauned [ox on ane ato op ae ‘wep asi man sips oy “ut a | “UsRTeSIO Wy Cf WSOPE spyiounys v8 jumsTOMEM — GFT By a cua ee ee a vee © seufeeu efgweqe Sons =| | epenend owing | [sees 1 2Bos rover © neue: eesunHe aqua ~ —q———— | 4) oaneemtionse ULsisi 9 me at we ta ton dsfisit al mers, Sngroserea | seavs prin suplimentares = 400 = ergocal ec a hipov D se sdministeaz® scldere aan seks reece clayoncesll foi | Si foes sais. | snea méregic produceres ymalacie defectul de calci- cone OI Te gimslea TD alice Stel Oo vai leat gi avind un ct ll este un analog al sitaminel D foarte eficase pe Tizarea eaiulat din oo jgneit. Min Jor impane aiociarea de preparate de tale $i fo fede Tactat, glo- Sonat sau carbouat de calcio i fosfat oi le nopializsca clcilsl g Fostauivt ia see. Io rabitizmel i osteo ‘isleta din cadmul sindroemelor de ralab- “ebje intestueld ee amiaisceazh infil 3p0 000 wi vitamin’ Diet eBtva zie, 02 ind apoi doza, pe misore rezalvisih €3- en nee gu alfe-caltdl. ‘Bxgocaleiferolal (ergocaletfer cefero. vaamind Dy, davitanon D, de Semendd witanina D 20 000-80 000 0d SE ia osteodistotis din insficengs renal Eloaicd se adminiveaz8 oral dihidrosahis. feral 250-150 ip, caltfedio! 50-100 18 De ssrmer ST fhidotabisteroll (cikydretactyaeroh ‘AT 10, coleamlne, tac fein combeterea si arene Cyptia wtamnine D, cae denvolt 1 full GOReS fenomece de hipovitaminodk tm eondipile ‘Srinemyl unor candy fisiobogee d& vie is oneainm, Aceasta fe dX0Te2 hull 3 yg oral sa if nteavenos. Le pends ‘Siminisueact cxpocueiferol sun colecal- {Sterol 20 000-60 000 w/a dsc poland 2 SH ta renal de exeapla fost Hoda renal (unde caleiferolii su pot activa Tunkel "Medionja dermasionic” _ ae preaiath re farce 50 pt ‘Toate preperatele de vitamin D sant te necesnrd adminis- tn doze mari, de 5 oxice fa doze mari, Administ Teagié de vitmiat D ~ 50.000 sal mult ~ la persoanele eu rlspuns a deternisa fenomene de hiper- jak. La copii, doze ilsice de icemiet si elimintsi osaare stat. Celeivl mobilizat 32 poste depune tm ferurar, biosebi fo ti to nefrocleinoz& difuzt sau n¢- He clisice suat: obo- $i. La coll se poste ope reir, Now D.pot prezeata insuficien{t peratroidian, (i biporeloenie i convulsi, Exist posl- carece hipefosfaremia ‘Retile metatatice 28.2.3, VITAMINA E Sub mumele de viterint B 2 pringi compost din grups rozofe ‘mai importa ese rt800 ones plemiges gefue o wiucs ans aemsedeed pono pasties Set 5 ar er tos “seme we cae 78D WeBTOPME HANEY) peony oot fou “elem “opaeay) & (Aor 1 2a os KeeaeD “END OF JY ko ouning “oD auoreEy umercea HO ear og 245 “Su gz “ada ‘enemoto, “emai NOD ‘cormmoy dase) mete> op roueroneg Tr 66 005 s1oy “Cet "yot00 op souairumy tm za cot og “emmy “pemosts) ay oenoA do (emp ‘paces 21a 83 005 “Cepmusy ‘rama "nus ‘poucydo Yougua “3 uous ‘at ‘o1z2e jaszydo2cl) yeWO8 [H}o49}o00, ‘aepory) 9 do “(ome 12 "xo “(euemED -waes) 9 povagosee 4 do eupsiog “urmgfomg) aoe moot Aa Dior Po fo Wo ow auaniosozpiy suena 1 0) S089 fae) ay 4 : 4 05 \erpey“ponnoemanga “ae 9g se -VINYHIOW N] ALVULSIOSEN! ZOINMIVIA SLvEvasuE ba we wd cad30 agit mh nine E forte (iofsrm, Rett), pa. gl 100 mg gel 30 000 vi. Viramind A (Biota, RomAnia), oP BIBLIOGRAFIE SELECTIVA 29. HORMONII SEXUALI $I PREPARATELE, SIMILARE, GONADOTROFINELE, ANTAGONISTII HORMONILOR SEXUAL! Principal estrogen aetoral ~ esradio- ful — se formeszi In ovar, tm folicoll Graf. Are drept precursor testosteronal, fe ergeceior sexoale Pr le seoundsre 29.4, ESTROGENI ‘Acoust gpl enpsinde Rormonl stein} comput dese, cae a PPC ia poniilizarca coleterlului pent sintcca [iGoilol homosal. aly 2 estogeal a _ sstrona fh este ‘nai polin ao8sh ‘Testosterone Estradiol a= Estrgnd ——t Esto we enabatiea™ ‘ru. 151 = Vaow A meta enroute‘yemovdns naeg “2 [> 9p dump [eo cpenstanape “prat 220p 7 prninumcoar nnueg yy Fajueesonso BEIGE op oapaede2 snmroford wn np aieloose ul — yie8 aise ooluefonea HUnpoe war "aon ‘ROMP g7ULO} 25 EA ‘oi ap yonzes nnaed um ‘eonucosten quns ‘aor gopemreyd sien ud aso pimoqoeid ecm sseyd snyonsSoaugy jaan crams eee “suse ap “Inotupr aalojntooe pugziios of Tn wag: renecan weary f opMIORS BEEP syed whup: poss "eunm Ty soa fone sqeesresdasospion pois te eeysospoe epun “sodepe Tate! 2 ej s8 ooBonso Fanecousr ANG Ton 2 1 yppuamdnsoonsoo ango 2p ssnposd tons ta8aRs0 ep form Ynnae terane ise Eoow|d ap ramet waRORde Jape “poy “ums esa oy woop tae Ho 2p oor vans ap Stale atpores safer ¥| gupd epuposas> aerdosd Hy 0 Up ‘uzooyd ango ap sey er snpodl jms ofanse muse made my rey omeiodsy injnmaysis eidnst arse ns SauoOy “ateeuodsy nasetodsy =p aetaoos et Joei2sI109 esis oA24p "Prem toy sniolio sacnou gosanond teele traxsdermice), estrogen conjuzati clinlestadiol 15 psi. Adri P get, de fovea raportal beneiciulisc uebuie eva i avatajos ua smonodependesti. lovosct uneor! remiss im cancerul de acai fniagonisac direc anéroge~ roacd frecant grea, dat ‘atro-progestogene poaic fi caurd d= ert inlenmescrucle nercgulate, Le bir- ‘ovocs sckdcrea bi fstrogeaice ¢ eadometrci, consecuty lipest ovulaie:, Dace sangeraca este ro- find gi periosloast ac recomsndl injec ne veosiune arterield Covers probabil geaeratt de -angiote fmedicamente induc enzimele mado Tizante bepatice, eccslerind inaciverea hormonilo= Estrogenit felon tapeuic cupring Epeoi nofural ~ estradiol ca alts sh ub forme estenfieste prin siatert, eston8, cstropeni aulfoconjugalt din wring fe endos gest in doze musi timp é& 5 "Poloszes de doze mich gi aspires 1. progestogen scale. consigershil ‘align el stamentlel subsist The estrogen. Studil epidemiclogice 2 fiatek de esemenca, © eestee modesth & Sieului de concer mamar. pebtra tra malt de 5 aa), &u thlesest ‘Botrdiolal (esradia, desl, diogyr, csrrafen, oertrogel, sytem, vazifem) sto ing ete peinepslul estogen je over. Adminis jronizatd se sbsorsbe regede gt fn proporie mre oped jemi ales fa ‘provocs malformail 1a ‘enbrelor, D> asemenes, foada de elpar. face es efecn sf fic elt a Fail scurla, Doge gubstimsivd, medic este fie 12 ge oral, fn taburbsle d= men0~ a Hecare lea, esosind, de regoll, un pro at use i) de asemesraseLen xovir (in menopauzi sau la femelle castrate) pentru fatava proparate estrogk nt produse fs we formesnt portind de Ia fnfluenge bormonuini. Mean dopinde. de seoregia progesteronsisi, fa neeput de cle compul galbeo, spol de cre placent. Votan lems cress, 56 ficege consinwtal miometrlui fa sciai colagens deote y omnis eruoMog sounds" jee ‘ones mmostrejeg ofemost: sonpat ¥ an \ sted 8 ginpdownuasod wg gsnnsgns ado ' ‘at v2 "wotonse wn m2 enfrooso wg “sis “oj so (suausisa8aud) [auosaysoB oe ‘fay Sze yin ‘novormore 2q 4 youn tea. 9 1 sonnésar mmnuss rex SPIE Sa “np ste “pie pu s2op tod “prmeONSG Sy aed wees angst 220p indo [Rutsxopes som 1 ssydiedny “RU H{ yrzonstummpe 2g opm koma ap faostl joscepoy — yeHEN(opal ord |Biseouye oun pe anemeye sa 4 Aoyanstoos eaisandop pres70 ‘erasers; afer “GH oneae(d fo) Spas fond anmp sued goog, “esr | quosasce, sosiogein sou gi) oase S geuea riironp FreoAomord (F amqaise - a anpignoud w gomeezones = = - 2 * ws seufoul a 2p jreauep gRse[om ne pues ‘yomnadery oy jmosectand opsed noo + = = os = pos auioaer posto Supe 2p BEGNSES = ade @ # ae | mee | Gem | iafemo | fame sauscisa) | anssgu shane | -rerbac) stone suicide | puueweoper | rue ade EEeen aT ‘enjieysoBoid exioygo © BoIGOIOIg BaTeATO ox nea 129 © peIBo|olg ERRENANOYrit frees To cee, $0 a BT tp cancer endomeil rcuent Se mets dove mast de 5 detent amelirwea tolane. B ore stone andro- cate poste relevant ie}. Este efleace pe cale oraid. Epu fe face prin catabolizare bey A sareiad, pot f torgi wil selesjionate de avort hs ful de progesteron a fost dovedit cu cer- tadive (Grin doziet bormonsle) Hidroniprogesteronal (Iydroxyproges caucerul endometrial, dozele ind de 200-400" mg a uv pe ‘mental famenoreel al prin ineufsienté luleald. Doze recoman- dminiserae pes ire allele 16 gf 29 ale irogesterona (dydrogesterone, dix ‘phastom. gynorest) wn un izomer al ge Sebideoprogestronul tn indicate ginecologice find Zilnie (a 2 prize), tee allele 16 $25, fe ciclslui, eveanal dupa o pregitire cu fcogeni. in avortal babitsal se admi- sreavi 20 mg mls primele 46 hunt poste fi in} ing dat Ju 3 hunk, In cazceral endoroe- 1000, ewadprpetecn Germann Fig. 159 ~ Suotre chiniel« progeseseali gi ¢ unr pogesadte destin die ‘poses. 72Imamnos eénp pope rex wo gjecouiog “HOH STEAMLAIOVULNOO “ese vee sou estto2souosay) {rponseBs0905071 “ejosno THGRIRD Yo9j3 n> JRABSp un ss9 sows praassnmiaiold sowgrundssios peg sIHe =Ie29p HEAP iueiod © am yeizo0.jouaiozmas0/¢ (Gerodusn adnan 38 sqeroutiog axpdovences som wilezadines ‘a peut “onosiny roma op aifaices BW flowizod ‘woqdiow ‘potossra “ous98 9p ugotoep si ORFLMSNTES POU A og losieaemsou gt op smitiny “Frame 2p entmnafoed som ¥ BORED omNNS — ps7 RZ yousnseiny yousyseury ier es oi of 00008 ee HomHO%HO: mel So nome IO es gw 20 _— oe "oe o — sor 6. %atracep for aedorte este 0,16 pet fu efeste endrogenice neplijabils ~ geal, gestoden ~ sunt ms ‘mon, progesttiy 454 estrogen. 29.3.1. ASOGIATII ESTROPROGES- TATIVE CONTRACEPTIVE CContaceptivele care asoclad un esro- tative contracept Ricoied overaii, cu iahibarea decvoleiit fe din femei si éupE 3 cislusl 2.3% din cemuri se produce | amenoree, eae uncor! se micafine pid la aes 5 (estaden 0,075 0g, dlaceiat 2 5 ck Hee Simtaigueask eorect, coma ucoute erik te devcuamcact ceptvele do acest dp sum foare efcace produce singerre de ip menstual; pear 126 tou preparatele care contin doze mici de Je tip 19-0 -balajul poste cuprinde gl compri abo pent allele de pourk 50 ma) si un progeste: ‘Se administiessd foie im cazul contracepBvelar este cousin doze miei de hormoti $i al celor care i. hcemefionnie #0 pet Oatd problems doeurge a faptul poate aves drept comery aegis en Saw thou courengeey bluguiOY UL BIEHEIGENN| o[ei0 aANeISOBoid-onse eanideseNuCD ox aHin nostieate, antecedentele de sareink extra: ‘wombeembolice prezeute f islipemia eterogend, adepomul hepe fc, easicomol de sta si alte carinoeme Dpormoao-dependente te necesard. prod “Medrosiprogesteronul acetate. it ind, petra primutzle pentru urmtosrels fia sczeagl dovk de estrogen Ine ssare de progestaly (de excmpla (6,125 mg levonorgestrel eau 1_mg nor ‘Tretencotul se admiistreazh sph cares Fela ‘Ua tip. pardoular de interven fe couprimate coniiadnd doze mich, care ifaulce aad ailnie, sub form de posi de comprimate, neti scceagt doz levonorgestrel 05 mg — sod contracept area mucusuat cervteal, cu fngrearca ermatozoialr; 29.3.2, FROGESTATIVELE FOLOSITE GA MEDICATIE UNICA IN SCOP CONTRA: cEPTIV 3 ani. Acjoneas res ovulalu fer 29.9.3, ESTROGENI FOLOSIT! OA _ MEDICATIE UNICA TN SCOP CONTRACEPTIV provoust reasyil adverse, ca Ima vastaoe, matt fi ceputal watamentl, fa po fe ece necesard adBugarca th foe de coutracepie suplimenter(prezer- Natl). Deed admiuiswares unei doze tn Uieaie mai mult de 3 ore ge contin tra tamed weual, dart oe se admvgé uaa seagerzle vaginsle nedieg- epic, care Estrogenii aofionsari contraceptiv ‘dete mari von, disconfor ata comporale, loa imediat dupS nage i eogtere in reutale, cefaee, reall gi vom. Se presupane fs endometrlui, EBcactatea este de 99%, rimele 3 7ove sojouerceainsiea > ,vojpyarsoipuy——> ,ugguersaibuy % eeeeeeies omen ES + Jousis9j00 > uoicueuBals —SfiaeiseBG]\ uawmsoapy [EORRiBOR| ( Raw] tnvznoavuy 18 INZDOUANY liZOUsIS “rez ne § "ayo @ op Bu joypousopune —soviet feminin, iloatatea corporal este fenitale Tamia subdez- 2 ual Capebile sf folotessod un precursor sndeo care 25 se comport ce factor Je (anscriticy etermintad eegterea sintezel de ARN gh Uaeor pot i obfiauteaoeleagh fi a vieed, der rezul- ielor hipefizare stanalate defscte ale 5 alte font cane, consumulul exegeret’ st ‘poate realize benef lea : asacat esror i pot aves consecinfe nodorte. Le femel s= produc fenomene de vrlizare, preneate Gore, de testosteron de. 200-300 . prezeaja edenomului de oi de priapism, mai ales la frostal Gi pot case volun, accenméed (ameatalai Adminietazes indelusgaté de- Jerenja de arin). Sercian gi penoeda de {ering diminuares epermalogenezei (=~ contraindica sub gonadot q De androgeni 1h ox ate provoca modifisee ees salnondosd sau! swmaopoxt tte, Fah J0un © REND eens — 95th goon voreysoupcon.s 0 ‘Benne ¢ op Bu 053i | ik 5 ot ‘Spm of Fn ea “ pmurcipey | isolidouc nquod queue pu eunige no ioIoIs r pouedord vaqsoe0 i sake ot Kr E 50° . 2s pasupour erayée uy sf Mame eS =p som uy] PUREE ¢ areOY 8] FOP socos no fode pogamuco “poqdaroo ear 1 “Lp eamdeul ey pmpmoussoson juan 17 nied wouog ur g'¢ soo gzeczrany osorege my pytcag eosin Bae teiBu S06 tode in ‘paSunpad sumtzo 3 NVZTTIMIA sulyisiud se "youorm “Old NULNAd esi wsmaio -3ud {Liso703 5p ores Bm Cop-OGe HERDIOAHcendometriale se vindecd spuclor. Tratamentul 32 200 mag de 2-3 ove, apoi dows so sade svervale stick ep je recomandete shat ee 100-400 > ebule exclasd 29.42, STEAOIZ|I FOLOSITI PRE- Dor lizante ~ provoack dexvel ridie8tor al egusul, msi mult decd dez~ ‘eziulelorceminale gi # prostate Ye qobolan, La om, susese curbe ‘pondered, denvolli musculature sit Favorizeatt suabolismal pretei. on Metanatonan Nandrolond decancat Fig. 157 ~ Saveire cialel » weer secs ansbotcan, 138 cue de peuas de 24 stp Formeajelcr_ sp! Tedicalii priate substanpele SEXUALI Is sceasts groph sunt fncadrate medi ccamute copabile £4 Spledice efctele dix 39‘unsey 9p spastied no gprourco gs atoure ayioeds proemuctone nud giseaoe wp erreurs IINSOOLSALINY “1-962 sprandsezoo fotseds soqpondscas jour 3 spnecmes Seon & ‘pup oad ‘yuobone> )pvamersyy "pansed aise loxgadretionny Ep 2 = Das) Roma = ‘Goteout ae a) ‘seroma eroens = | t | = ome ite ors| ‘esodee eee) pmapewne | stapes be eg ee el 5 2200 8 arensaqupe ap soqe> “qs edna —'pluezioqead juoafaepoad aumffve no pony 1 aateewTamoston 29.5.2. ANTIPROGESTATIVELE cxpfcual, nchisiv penta contacepya post dar axe dezavantajl de a deresla sgonizsres Svinlor saat endomatioze, Ieiomioamele, 782 gesteron $i luco- hing. Evsloarea Ini pent eceste indicat 29.5.3, ANTIANDROGENII fo face antagonigtlor Azilo impiedicale pria antagonism com Jn xivelul receptorlor pectic 00 magi), impindicd denvoltares sexald rcoee, iiogoeaz2 impulsuile sexuale gi emmite deavoltarea somatic normal ‘fecha dont dazele se "gonadoto iv @ aiveloul plesmatic al tet - perimentale dozele mari de ciprotorend 3 hepttoame, m3sre cuiseure wang gysuo> imo ‘prnedonsts Rica epnenaf pruowsoy Bate onepeed Soyensy suum sip eesiga a ‘Finedowour 9p uoum sagosjopeuoy ‘srgOR apsyeo ed “srgodigousry “pan me ‘suomause jf sunono joint Pucun sxyfoopouo$ prgeatsd s asopdas oy vosoday for wo footy ns spujonopouot es sanidaceptoop, STENKOULOGYNOD “}s6z “gmayodiy-omemnodiy corto

injetesad intramuscular gonador ‘se face sub supravegherea unui in folesirea aces ‘poi eu 26 sociind menotropiod tor me sdecvate de ururire biologict 29.6.2. GONADORELINA St ANALOGII AGONISTI susului. Prepaet mente - kripiocur, LRH, lurele TE-AH ~ contin goasdoreliod ob ‘Gonadotrefinee, opus dir gi ces corionlel, pot iceoa thule jlogicé cousth fa contro onadarro csinieant. Esrogenii st reraitd un control tetoafereat urgety Shupea sistenmlui hipotalame hipaa & specifich ab cel Isler gonsdotrofe, er und Cot ‘Gensdotropinele‘ouodoatso op aces posts vines orp gspurimecer seo nt —— Or soy “emmBan, sR) seo Sur ¢ 360 (hong som ‘50 opt "8 oF sau ‘qufabs SADIE) e0085py youse2epy 38 005 ‘aur ot “Ho “eile ‘woldg) avai ‘uaqoe 29 gevansyannpe 2 “essmnege y smoot arom opge sxoqidon “amptgo ap (alsls lalalslale [= ett adeno tt tmcalne ge © dslsl [alalalsle [F ‘Parametatona (goronerharone, der EB : g 3 2 ‘la |apalalela la elite fs wesicie Mise mete = 5 S Fainere a stn opel Se adminis a Sal, fa dead 2 ae de 612 malt gh g : God de tonejace de 2-6. mate Mi eoe a : i 8 3 é ‘ & ] ] g e Falelt |e Pi aa gia |i & \Slile |2lalelaye i alale \elelel2l2 no mee euopras # eaBones ZomgeRD wo; wa evone1d Iw seop na ennjad fem, "BooTps0. wYfeorpeur =p asuposd 30]29 Snonmmpmere nos sieape epzioe, loos - ofoqoyeuisp # sy2ojourmzo zm aaeed seaden! # peng “om pune uo p 90> tf HORE sae co ates oy ome aolsies) sewBojamen gq apm -ruxep) sajrof (6e papzendno “90g 7 Ea[es ge[noefout a Smt ppl pone ay Bien Jenfodiy ae aoncoqion op 2p OS ‘ouey un aise “ELOY es vindauz09 Suios “faydaroo109) wayonoop0, anaiovsooveiaL 18 VHISOULOOUHOD Toe Sap # Huyenospioe aoep 6 oYx hipertensune arterial, Teli, Feaveatewlceraui e Seve mai mic decd! peatru corticotrofina > stu Preparate de ttracosactd retard (cor- srosy depot, ynacten depot) cuprind su8- ‘seetat ea hidroxid : . ‘eute ale solerozei in piel, sinérom jules, unele forme de epilep- ‘ozele recomandste sunt de hipofiaas, ce unmare 2 secre de bicreconizon. Iagcruperse broscl 2 sel poate declanga fenomene de le adverse. slergice sunt posi semlate canusi cae de soe 30.3. MINERALCORTICOIZIL score cdtiva bor ‘racpels) Bind aldosteromal — sri tn metabolisil elecroifilor rncpal, petra Saget one Somicosuprarale. fa a stl subaonnal (alvel plesmeuee me peril mare, mal aes fm feat. Administat m1 ce fm ucleu, unde se fixeaxi de croma- tind i iaaenjeazh. consseutiv proces de rmantcriptie @ ARN, respeciv simexa pro feied, ModiScares ransporalul Tonle meme 9 latea de 142 ore, timp accssarsintezeuncr protsine speci= ‘ier Is nivelul celulelor fata, Favorizarea -reabsorbiei wala a ionilor de sodiu fnue\inutd ce secteia reactivl de eldo- seroa, poste 6 combanuté prin diurer ‘anialdosteronice ~ spironolacton ‘amteren si amilorid.*ue somony # aefoiewane sieereis” a210088D oo To etinks Sesemnonmao noses O18 emg qezoore ssipe cess vesiooy eeuaig Cameos oe f sue fosoipy simua) geprduy weed soo sopneo exdase poop porch aunCe ‘nes Zo]RIosmsoonog ezIMS no TES ojo fda Rosse MIP eyIOSOMTPSG §ZIOoWYOOUNY “yo sora “Bap dose 0p wrecerMn 25 roodeaye (preapeersran ayoquem) sorscopmonezep =P “apoxe oj ‘woloonpasd ol yeseoduo aso oroieopre 9p [mEUEC =pze8 RICANS ‘iro ~ 92 7 afarsomUU Freep © BUI S -proonsctreum da op sedo> sen ¥ aes wENS ~ Eo" FLY ozpeeoipnis vopeonereg ossopry 0 ° ° 6G [yor oY wo Ba ot > 7 H me op ies “OH Hohe oH HotePREPARATE DE GLUCOCORTICI CORTICOTROFINA, MINERAL CORTICOMZI §| ANTICORTIC HREGISTRATE IN FOMANIA Gtueovorticoizi on, Finlande), opr. 4 ig, ac. inj. 250 mg, rol (Mustafa Neves 4 mg, 16 mg Prednol L (Mostafa, Neves 0 mg, 40 mg, 250 mg (odin suc: Hldrocontcone (Hewofeam, Yogoslvi), fac. ig). 100 mp? ml, $00 mg/h mocinat (Siomed, Sg ‘Predation (Vsamed, Sees), ope. Sma rizmeinoion’ ericon (Betlin Chemie, Germanis), Bristol Myers Squib, ie 10 ma ta, 40 ma! ac. i Fludrocorecon ‘Avtonin-H (Metk, Germania), opr. omg ‘Antioorticolzl nid, Rogluten (Sind, 250 mg BIBLIOGRAFIE SELECTIVA rol LK, Hang, eh - Gs ngs aoa Ream. Dit HD. Ae, at : 1, 2 1994, 20, 629. McGowan JE. Je. Chesney PI. “au ce tame gine porate ypopiyirsarentiea, Gian’ 12 Plamncsope cg 2 ie GEE, Grecipan FS ny et 9 iose oowme og anwosdsar tz wp sendaos) 6 V ~ sorpnded nlaey ¢ W! x00 18 O00 9 capoula 9p 3H a ‘neq syn op pelaios sys eo ‘wNTInsNt ininuzavia 1nLNaH as 20 soogo it op sand 6 ypotetonees ded ywomies gman eared oud “uae saad géejo pad o-ney qzesTEIO} amo ~ apisiaud-aid ~ yosmooid sip Hea ey sompgynsip Had gnop wud ow85— HSUoG guns noone Hf eons TANODVONTS “YOILAEVIGLINY WiivoIdaN “Le Fatarodoo 0 yBnepe 2 ape) 2m Silom ono 24 onto “gorsienampetaeq cami) ‘sumpom ‘ajeagind ojsewdand |rTagsun ot metabolice - subunitate Uraufetnia ullzee @ gucoze, peice, hlderen posucl de eneria | eakdaren oviaol potent, crogiarea gucaneo- reed od i eta heroin capa In osue gi slenel] Depp potash isosklar 95 000); 0 leghturt subunit alfa gi Nat, actvarea trozinkinaze. Se produc fosfo- — ‘ie i cascada, cae roglazh fmogia wor | 3 |. protsine gi stimlosca sau inhiba expresia ~~ -genelor peotru agumite enzime (mecenis- Aifess ale Ianpsilor poptidice stu ca alter) discrete ale sedilor de legare de subunitats alfa (M> 135 000) i beta Qe 782ny apedaarvugor proen EgSTSE eusdane RE 2 hace at fetGenH agony 90 Fy op 0 YeaeTupe FS Fane oom eee eeeg uaae 9 tz eho ‘was ae 1 stgormange e) piso [EP Weald eo op amine q FREEADSTOH Y ‘ERe-t ¥) REIOEEN gE HDG EDEN =p auseony eg # sone learns : epied 8 eenog spear ajsunasay mo sfferedios wy Summ purusuy apignzenone, ato taraeet ‘toiod $8 wyaog somsog 2p serecume sa TEE OOL/Sut OPT € fam oy soNeaHs 209 ‘aoadiouou, mugs ~ 208s $F oy ‘yoiod sui8uo ap wourenmes i puna — sagen no yee & wojreadmne Out unt ia) geudaoo aysuadsns oup eoySa] gore 2g “7a egos “alaes ap nioy qne spoooysoure giiqnjos gue ema sep op snfep nora sp cyereay meager Few "as 6 p@uies ay 22ay syeod 29 Ho, sony Sjnuor EOmRset © sep ep HEE, |B B100 Riemp op yf spides rinse eon ns zopeneqep[njonaeo narod mes 2079Sulfamidele antidiabetice exulsele - fonomane neurogllcopenice. ‘Faint obvervajia. cf jasulioa umant, pro- Soacd mai pia deeatinsulinele snimale Tennne do hipoglicemie, ozs ce poste avca unul aige mab tare de reach 98 do sulfonamide, in majoritate Ripoglicemianse si selefiouate de diabet, ‘Aoeste medicamente pot conrola hiper- ria Ie preparatele ,eelati rar. "Se masifestt prin fenomene ‘se obyia sclderi cu 20- ‘jean. Se rocomaadl seesinul de isulind este ‘Sulfamidele antidiabetice actioneazt si prin mecantime exrapancreatice. Acestea int importeate, probabil, mai ales in Coadiile watamscataler prehungtty ead Gul beparing, fenolfaleira micgreanl efos~ Shi icclinet gf fevoriea2¥ hiperlicomis. eq) pot contola, fa eontianare, 81.1.2, ANTIDIABETICELE ORALE Stlfamidele seusibilzesex celalcle In ac. wood fonomene Upodivejice loea- _Aatidiabeticle orale — suifamide st ust compigh de sinter 2 Fcace In ace le, si eovenle la ter. Lipoatofia este insuligele a de temperotura sclzutd a pre 2 predomint la femel, Ese daiontt probe” un este indipeasabilt, 190 71spzamyms 200m ya 9 tangevs "wofaar op anos aa xcon|d somegna| 6 {Otero 2. I MILO Ditton Coprpant Quran Oar) “ Manakin Fig. 168 ~ Seuctra chin a uaorsulfamide anddiabedce find activi doze mari ~ 1 gle pentru proferat oa doza slic ek fi fractional enuitgad explorates ulburéitor ghucidie de astur heparca. Efecal esto de duvatd re. tostabolisauias giueidio tm ineutileaye lan soured ~ 6-8 ore ~ de aceon ete do bopatod tu eau 196 “Ha 304 “aozpeDospIy “oumER|O=aTs ainpasd sooypioo uguaudep voset09ue> Amad soeays y syed jruofeonjDBIBLIOGRAFIE SELECTIVA pc (Sindan, Romina), cpr. 5 me iidia> Fania, Tali i Sindan- Giguidons Ghurenorm CLerpis‘Boebsages, Romt- ni), pe, 30 mg ‘olburamidt Tolbutemld (Aemedice, Sicomed gf Sin- ‘ofa, Roms), epe. 500 mg Biguanide ian (Azmedica gi Sicomed, Romt- yj 20 ui, 10m, @ +P) BIS) ope 00 Glucagon Insuline cu actiune lenta st dura bila Gtucagon Glicogsn (Novo, Danemerca) fs. ij. ime. Glucagon Novo (Nove Danemare), fae inj, 1 mg,508 ‘ssoteced sjeaeomopor © if ruspom roreoumog « oR aumONNS = oct ees cukoponp st psamoperouoa pene oe eee eee 10m r9 Tom umn ioo8) GUS! Ip SRS ‘= sojmuor eiequeoua> opeae vo gptided "hod ‘nigueyapon ‘anodes ‘wd ‘ameotog ooqnoo ap szadeo cise 5 soe aos jmpoy“BuyngeT%asti ~ 960 O19 aberss gusosjou eieal a>. yoymossee INBIGIOWLL INOWUOH “ze YNVIGIOULLLINY viivoidaw IS INaI INOWHOH “Zebdrenergic, fenomen iinportant mai ales entra sparaml cardio-vascular 1 ssjiune important este accea de in- i hibare a secret de sirosofnd hipafiearé = fect supresi, care corespundes mecanis= ru Aziologie de antoreplare s funciiei irons’. rinciplii receptor. ai ;- onnonilr tidia! fae pare die sess flsese tn membrana mitocondriala,acio- trea lor find impostantd probebil pentru jar vaele medicsmente ~ saliciloyh, fen ton, anizoagulanse cumarinice, cofibrat Seplaseazd hormonittroidieal de pe pro- {- aivelul ADNealui, Un al teilea tip ceptori sunt esi eupringi in membranele Celulare: acicnszea lor mireste provesul e caplere « ghicozei gi aminoactzior fn fine elute. A fost deserist gi 0 stimulare di- 808 307p aod Syd stor armed? a) yew wu Jons sussosen fUouoy =p 2220 doo “ona ponpoad ye guy) "Rogosom 2p sh ‘ose napa, atsodne dons 1g e761) ¥ “pomoaey plasma op gE joo wesw ‘sem nnaed ‘ammpaqns dos oy 8010) eq yevafoborm SWORE “BOE imstoo B proouedas oo a ‘saned Sy Qr-s “Font 1 srqmd eprom ‘eugeuponsy 25 ‘wo ‘=plomp pues © amEMAE Hoare uSigo aiaoep = prusypomoder sojmoy modanen 2 pagoasteo aR ‘p yemgye 1 yo nvomsyenoco oye sumos aoqedyo A “OWURIGUUOM Ioee-LA-H EN ® BONE‘wofink este ull gf a bolnavil ou gop Tirolda pulbere este up prepara brut Bfectul nei siagure doze mari se fuse. Jena dup 4 ore oe 32 fermi to crea ugerinke infestcit cu eluperel a pre- eral Prepaatele hormonale droidisne agna- 1 cardtopara ischemicd pot provo- foase ~ se introduce ta tub intragastric sau lotravenes ta dos de 5-10 ug le imervale de 8-12 ors; mu tebuie depiyite 30 hg fm primele 24 ore; dova subst {iv deplind este 100 ug. Liotironina poste fi utlt peat eupresta pe termen scurt © scerejed de rototial, iacusiy le 209) Giagoos eplin efcase. Supradozarea hormo- ideal decent feno _ a0 "32.2, PROTIRELINA $1 TIROTROFINA 30 minute si rev Gdupt aproximativ 3 ore. Stimulare secre : srofink poate & Hmpiedicath de jamie de 4-5 minute. Se sub form de preparate obf- peas dlagnosticul dis profilin’ este marca ‘eoumdsr (bipofiza) sive {$1 trotofisel plasma mu 8 re ironink, de asemence, $1 Sroofi jonee tdiedotronige. Aso: ‘cierea acestor tmedicamente face uncori Seessui cryieres dosel de bonne. (Ca real adverse posts provoca gust retaic, grea, hiperteasiuns erterslf, ue Xoie de trina confuse ~ ia general mi tick Moles exe frtaté din. 2 asi alcopeniee ~ subvaie ee tc nts Sect askport Ia tgetia ene ab gt gosedowetine) gh beat Boert, unde ‘provoucl creslerea producfiei Preparatele farmaceutice s¢ obfin din hi- Gelber de trowofas prolsctns. poses de bowae siesesee dump ‘quyumdgs wast ‘ye enaigo edep arede [nvoayg FPuocnog jojo puyegoe“Temuoa en ¥10p 2p soramivo1. STSNSIGIOUILNY “e-ze soqmeaoys ‘fad mm oe sito puoinguoses pun edi 0 ce 8 op a Semen ge ung sp ede up go tmmeredaig “zeo0| afi yo ade] Ul WF posyoaceyd smug OS oes, n piisaqand 2 43} wip opodat qioeqe 2 cu iy 9p 202uI00 Tay sovowaxd Jojapneon sarezopeidng Rae eee sco “Sjeuomy jaussres pryumeTeo sno year ef gaeonoyise euganot] Ha fortge ep wins alspunoss sisajg ase zeus |S yeesepe oFGat HOH coca i <> <> ae awoged &, Petiemst art Toot «adn tia, Timpul de tnjumbtiie este de 6 ore, tro singurd riz, Beneficiul © evideniank cova mat repede decit peo- Uieidian’ normals; dupt cies se alunge la doza de Sntrefinere de 50-100 mgfa. Durata stamen- sie de 2-3 anh ‘Reaciile adverse sunt cele obigauite poral 2 cel putin fa acest fel se poate realiza xodicwren gag. Ce eft nedot 1a © pro- porjie mici de peosne dig zonels cu sd endemich se denvoltS fenomene de Seri

nas =icos 6 premncor of myusaje samen; 2 pops oqooso Hlosyey ajeur op areoveurojaaasyTrahenet 8 pene, EY Tea 88 8, 198.1.1. PARATIRINA $l CALCITONINA 33. PARATIRINA, CALCITONINA $I ALTE MEDICAMENTE CARE INTERVIN IN REGLAREA CALCIULUI $I IN PROCESELE DE REMANIERE OSOASA, VASOPRESINA SI ALTE MEDICAMENTE FOLOSITE IN DIABETUL INSIPID, SOMATOTROPINA $I MEDICAMENTELE CARE Il MODIFICA SECRETL PROLACTINA $I BROMOCRIPTINA 98:4. MEDICAMENTE CARE cosas do nivel call te. sags INTERVIN IN. REGLAREA CALCIULUI $1 IN PROCESUL DE REMANIERE OSOASA ‘Hormnonul parstivcidien ~ zoratirina ~ mina, wa, bormon,tiaidian, intr~ Paratirina (parathyrin, parathorm) aa porathormonul este hormoual secretat J¢ oufiaut de 84 aminoaciel mast mcle- Aciinca ‘ilad elaivd de circe 9 500. Seoeia este jit mbulare a calcul gt micjorrea res 7 Viena D fi clit eoat expe fn eaptlle “Viele posable respec 2Caeh™ a9ego ns HOWE wp sages ojanemonpem 2 3p docu) 96 magoumeiez] “sme! osioape 21 sfeuemen ayaRasep pagorperdiay 1 monqingouas ‘omonsel 9 (eovase wi) emer tasoEARSO © “enpouot sina poe reese STEOUdaTdSLLNY “LP Peron | fom, apis se sending sexe sate 22 ib ‘sreoqpu aopdayopme pjmomenpam 8 apsleyMds 2p MEH a|EBNG ws00 IngeCateva proprietiilfarmacocinetice, importante ‘ale prindpalelor medicamente satiepil Meteanesnt | metatare rcp |" haposcs ct aot ‘Romania | 18 | imei | ae ry nox [3080 (exe 10-0) iamnat Te [sani [30 | eaaet 4 rea | Sa] so Te atl > Camssangin | seo | maf 1a ef oe iesvapee [50 [mad | ip Besoamie a =| Steet 3059] imo awe Tiowwies | 56 414. FENITOINA $1 ALTE HIDAN- eater TOINE ANTIEPILEPTICE ‘mod regulat, poate csuzt ii, primidoned Uecnazepnel, Medicamentsl relent spr ‘La nivel motecsler aoiunes principal « fevitoinel constt fa blocarea canalelor sodiutui volte}-dependente, ou prelungirea 9192 idoud sone, omIETSS WHEN ‘osauoo earofom a3 ‘sibepar 2p (RESut pots arajam 0 ym st ap soneUET|S erg 2 enoouoo ey ogvadera eorneg Eo “onpioo wamenfon expen rorodonso wyoxzep 10d 2g "Fonstenied; poate full ta oa2 de hiperson- ite la fentoind 41.2. FENOBARBITALUL $1 ALTE BARBITURICE ANTIEPILEPTICE asst. caw reagiille adverse toxice freevente pentru ‘medicamente autiepleptice Spend enc Rese adverse lace Giaie aah fo excep (Giase eajom # ile pe Sa a Case cece Pan ame ee ite ns weed de woes ‘Gera siododsn rile pale wars ieee Saaea de Be opepae ‘Cause ween, lute mina (eta) “Rae, eid, smesens, ef, Gis, ee, roms, Case parle Gata), ‘Somanea, chow ape 2 ‘amc, ele ony Sees orjia de crete clad pHa uroii este alesin, rine cipalul metaboli ~ derivate phidroxifenit Sn de la concentraile de 30 pal pot Fi severe Ce timpal, se dezvoltt Censderabil t condi erence. Le cop ‘medicement excreiatd renal poste fi easzA de dificult goolare. Adul- 983Dolizante (la dozele mari), eau competiivi a azestcra. Aciéul is metabolizes fensbrbital Primidona (printilone, hexamidin, lo sina, majsolix, mizodin, mylepsin, repso- tine) este up analog at fenobe ail Rezafile adverse toxiee so aseumin’ ea cn cao le eaobasbtll, ff de ete pri- ajow generalizat, exzele psi pe peroure folosiri) primidon Fcgorrea dovelor. Ocaziond, nal Recvente tetiva i fenobarbial ge bu a naschismbat | “| SE al es cousile eetaxonte! fadelungat, sual leet ee SieMgml grmidont fh 1620 valol Sc Roba metas de fn ‘Nivelal plasmic co 414, CARBAMAZEPINA (IMIND- ‘ STILBENII) ee Carbamazepina ( Ea : win vn le a Bre A, Doe Wo ~ Aga ap Map JM 1966 38S 1B tod ne 100.350 augial i ereseiad tep- bapon, newrotop, sirsy aso wae ‘cezeape pfoear ojzan 2p no adoomy a= [Favommen pxgo ‘pIepo=ED spe ypueose ery. eoonand ayeog pundecrussse9 poops megoues pacmey unwoo66 sopsoisand of cotedoy sayfoeny jaion09 conga 397929 86 ro ay sjucunvodiy ©» SGoronpoy feuseyg Wderemregzeo quodns fu ale> sfouvosed | gyeofeioest poy -oonne “sio=nE Syenouon sent soe pained waenra[ od wememoe |] orn pte pe compere a] 1 merry |b sessaameyen | soso. oimene eonny | pieARE =—"yi wespen weRRO 4 Son oreeyey eiuoxuwoqpaar ope famyfousonUy BASIE)Cateva interaetiuni antiopilepticelor ex alte medicameate, care pot fi somiificative clini” TaBELOL con Tiamat valli | Masimocal tore cota | core ajo ie ale eee ‘anacbins| Geena | foes ‘oiitares pia ale weliaasste + dll une soe epie oneae ‘st (Geer Teng (of la adult, ceva msi mie le copi Treaties | 7 [teenies ‘Concentafile plesmatice eficace tera- ‘inidont Tiseatai [Tainan aod Toeabaiae | t | Peed ‘acai Slaw F____ | Feectiee ae | Gerad met = 41.6. ETOSUXIMIDA $1 ALTE SUC- Foss CINIMIDE Tama | Teameiea | PPro i aka? mediate = sedi agit gastice ~ grea, vo ., mE, epigatalgi, rereori sughil, care pot fie Fenomene de 990 ‘meatal mn este certi Acidal poste ereyc coucentraia plasmatick a eto- Se absoarbe aproape couplet si rea lineant eoucentraia plasmaticl ma 3 ore ‘Valpromida (velpromide, depamide, oe Alprosin), amide acids valproic, 207 fa asociatic eu alte antepilepdce, 18 ex oo266. opera yysd seman 1 272° sjorap sags 099d0 10d =! ‘rp seo “SIE a aca oom stad ¥20p ie impe 3 pau doo 3 fougp “wdougys ornag 0 259 (180 auederes05 “pueden “undsr047 BOWAETISLINY VO 34150703 SNIdSZVIGOZNE SW 1S snniyaazvia “InnveRZvNOTO “847 — ssontoe perpatiat Sposeime svorpeisuien Te don pe PRETONCS) a den" aI ‘usspoyount) CHORE DOL aNolaniaiiozvx0 (deft “meeenscot) covog wind RUE aise ep penser amegoyacse feuded amt te “speazensuayd) SpNESCRZ ‘isos spelewtenez2) 2 fp nro snes 2p seyé sssisierd 2p shoudcomparatv slab, pamul te distrbuie repede le creer, cece = expla Redistrboicee cle mage stermind trminarea oe 41.9. FENACEMIDA $I FENETURIDA pilesia psihomoterie refrat Fenaceida 106. sab 5 abl. Se poste asocia lepice (fenitoina, feaoberbi= ule st he depois tenia grav ‘inurl. Iosintes insti retamentulat wanes Feneturlda (phensnrde, camide, deturid} are proprie toned Se ublizeazk obig aplastic $i sindrom Iupoid 4110. ACETAZOLAMIDA $1 SUI AMUL (SULFAMIDE nH ‘TCapialaT Wesicaiaanigloncomatoae vith dexvolara tolerenel Experimestal, acctazolamida inlaturd ‘componenta tonict ¢ coavulailor prove- fate prin electrogoc maximal, oregle pra- gl pentru convalsile eletrce gi prote- jeezd goricell fata de com 10 malkg gi a Ge seasp adverse, dossle soni pro- vouch oboscald i parctezi. Ia condiile atementll prelungit exist o tending la seidozd cu hipokaliemie. Rereari se pro- ue enipit catenate, foarte rar agraatle- ‘ecesar coutoful formulel sanguine, al funoqiel Heal gi al funeted sania Ts diabetic gts camile de asidozs exe 995166 gro aronaseuupe a yz yam 10 ‘oud obey oe mmuasamte anzdo ‘sondot “ots sip Based =D paoy ‘zap zowoy) TROIS EONIOT BOWAPUASLUNY BET “Zit SOLA TIdSINV VO tisoTos SONY “vil INTRGIOY IY 1207 “WHY TW 1S WANRLLVEWOIA “LEI rondeq 8] oypopent09 sfarpgsur ‘gonedaq fiisje aisy@onasine 0 nsso3treducerea weptatd a devel. Melsbolizurea sestu (Cncs 49%) ee eliminl aemosificet lamottiginol este crescutl de od iia uring. Timpul de injumitii toind, carbamazepind, fexobarbitel, dont gi este redusa de Valproa. al enzimeloc hepstice. ‘Anieplepicele indctoare ensimaticsereeo In acidul geme-aminebutire ‘metabolizes felbamtsli, iar seein Felbamaial se sbsoarbe bine diz bul modifiea melabolizaree alter entepilep- ‘Sgestiv. Este metabolizat pari! th fcut, tse, de aceea asvcat i le polensanl. pr ecle Anglis, Teva, ope. 200 Fenton . Fentioiad (Armediea, Roattnia), “ee. Cerbasan retard (Seno Wintrope, Gemnenie), «pe 200 mg, arbapon Hemoter, Yopos 200 mg Neurotop, urorop retard 300, 600 (Gerot, Aosta), cpr. 200 mg, pe. v0. retard (Destin, Gerais ret. 150-mg, 300 mg, 400 mg Derivati de aclzi gragi i analog! GABA ‘Ald salproie Sbril (Merrell Dow, Frans), ope. $00 me, Suceinimide Beonusiwiot Peiitnid (Gero, Ansa), ep3. 250 19g ‘Pemidan esis, Gorman) 93. 250-5 GGotecke Parke Davis, Gere ‘Clonazepam spsin (AD, Germania), epe. 0,28 mg. 1 Gloneae a, Polonia), opr. 2 mg Clonowil-2 (Remedi, 2ms , Diazepam (ijecabl) Diazepam (Renautin, Frans), sol. in * Sutfamide inhibitoare ale carboan- hidrazei Aceiazolamida “Acetzalamide (Life Phare, Talis), ep. 250 me deren (Terapia, Romtsis, pe. 250 mg Genephamide (Genephamn, Grecis), ep 250 me Alte: antiopileptios Lamotrigin Tamicial (Giaxo Wellcome, Angie), ope mast. $ mg, 25 mg, 100 mg BIBLIOGRAFIE SELECTIVA@ q 8 ——— q soe we [8 5s wnt Sm’ ia a ie E g 2 é i — orellc (2 wets eet wee {2 Rae amy x sree yEME 3p jm sre nes au [Snags jad same soxfojoned ‘ome ono wie 7278213}09 STSNaINOSNDIEVaLLNY "17 gon aramenorouy ‘Tt SIVULNAO STSALNVXWISHOIN 1S STANSINOSNDINVdLLNY “27 soy neg ata erg Tar 2 tonnF dea qeymoen papuilede dpnded 2p YRSEE woMUNI |S "emiyeveapefox "2U30) ors - enefojg sunc2 16 vo ‘ sionsqne “108 Snaoe [Raje Weelisiod =yeupasTs Seg simp 2p sweoreee=s efeuKl, erorone) #6 svofodye snardoad 6 sor © spor, pp pfs ay) axpdcopow cio 25 papain sooo aafoe 26 came agug wens vm ¢ od yreemp 0 1 Fem sono Meomen upd yuoon gandeoqoa meat 3 HLSINODWINV IS HqlOIdO ATSOIZADIWNV “Shexemplu combeterca durcrlor anginosse pria medicsmeate care corectcazt dezech bipofizari, posibil prin ree provocatl de cancer necesti, dup ca, radiotempie, ax redicale sau chiurgical cular spatial a acester medicamente cx prinds 0 formajune enalgofor’ comun’, preespune pil, ca: virsta, sexal, caract ‘Durecea tebule combatutt atusel cad devine © cav2k importesté de disconfor 2 ssn pnt bona lod gees Ts darerea cronic8 dstort® uacr boli organioe tstamcorul se adrescanh, abioch fed este posibil, ulburisi de fond ~ de 1082 eptorilor 6 conti. sie gi, ta mud, a suprespinala. AD 10835901 “for sop eidose Hime ouol qwoajg "eHendésor vansdo op guRd EEESO -noig n> qaeajog ay somecap pug “etes = oy, we) sopeihe renrojunge presmnasiny ‘soMzorg ‘ops sjapjondo reaued sojordsool ‘foe engine Tors apoido ap csmposd 2a ‘vo oyseen048 wareooangey“gue3t oe) ped qusyiorm 28 suafmp mse (dou y syeod wifernas ‘S| suafas op assis 0 sonposd sot igo soHfojomf sojeuusunsou pmpuse o sbppiidad aus pugardan “preasoine luis 8 poms pzpoun> 2109 2720 oo = © wosoaord “20t01 BERK vee oxms 9p gar Fi [ord “chap spe pmocond syaadige 2¢20q, ar ‘ipopou eo ande a1e> 2a! “sheet seporenay wooed eure rrciacel sare ] ae Senet sone “EER, pen rramoags siegpsoa9 sim endo RO eH yoni sanmeg Beer som endo eriopeu oof spioMo aoporstieae oye spe apHep B sRMeM IAN PHT asec TaTase “odo yoxdoos 9p pnd aopeeyp soxshaonpel ap efoany dp ed isos agdojus © B soeRue soppTe won6901 esor ‘astane ‘qUOpEOM no mIROOM 1s a70E Trt ec = mig emp Seabee tuje a9 poo edo rannag "e208 wIpIO ap sTauraigexd joredoyed avsiy‘szeoyhpaoe =p estoy Tesde -oxap ‘soo ofdanxe 6p “ape ejadngy“qfoesmene pe" umn ‘Hzepdoow m> qevajoq of axon uy opaBoue RIMOMTEERL, Sue amano 1aTevE , oa ap 2a oud ens pm? no afoot oh pordo en HoFSnATTDE iyseoo op itive SOUSA [09 aq suena Sot op gpruce [RSSORIDST “sHNE oye usage aedipeig “@20tRIo “sends found wepo ‘sdojoa wud sysptmous Eman 12 OTL Bdep 2d aud grasa 25 afeurrdars 09 "opioe “Pare STEIDENEED OND ‘eudyod ‘argomar uanp edswootura relead e pereielui abdominal le comparabil celui al acidului acetlsliit, si preset ls am- find de ales peniry combateree durerler Je intervengii cbinure- > prenorfink (ectve fa doxl' de O44 mg) la 200 peatra agravate de opioids. imatismele crantene impon 1 cna sitatia clisiol 0 impune, arcetind - Tutoideauas un aatepasus efieace = ace: irons, sie 2otina, dexropropes de edive boluay — asemence dispoaitive Soars ia rl Au fet sage ma dab, sat proviee ex nections prlecoue fiale peau dlaguortic (de exempla os tonravopaolxo “75I9p0O yous ion 82 aie EPID amd) eapped "eUOpRIOM pious soafe aie wEgrO yous eavonemmUpe 2 PHS PUY puns ome ‘otmaRs 1 stn fyendaat SEELidop “2D0}81P 325 pos “pigogcoe eam “ae “ome Zope tm sony reeds gene towne vo res Hee ‘sor@ojooeuney JUNHes FETE op yf woqamtsrass feaysp op ops 0 pw aauge "de Up POOR HEUDS “peapmase p peemeony = SagHoU Spo: “Se nap oe amo dus EO (1 oyequose queujwopesd epjords) auvoLyNYHIaSY gipasa 19 Sa|0ldO 301z -goiviy aLiy 1S VNIEHOW “Sr lunuafnaos seaodog — 90 ‘tes wip togo ween ens 22 [HED ‘ynisuon i Tals “FESY 9 ee Epes] sqpentotaasa | Seimaanep reer Trenbes am eee aE pecpapee wea {Rechowosa oO rpranaaor Fac ‘po waavt . zor ote — sxo}duoo simfoo no sjaploo ‘ea for eopntoyod erecymy ao “o=uENE “Giber dootod dap posse "7 puoxderex -ojowged sioje op games y vod tseajog 2 ouguopesd piedes0> af amp rloesI01 radeon and RUE Yarsd=p “1000 |e es aniqopluase 208|e02 109) "aoreizad (9) 2p ~ uluoBmrumfioso tnoye oa 29 eHfoduuoy waansyd ao 1» raotouzoqied seated pa) pevstuongjeyziopictdo 2 sjodum eqmno mnod :oeuoda 101 “eq “stcjedes eouewiadap of Bs ‘ andod omasnfe 2g Doyo azominoe 25 gs pon — (nueyKodox! vrop ‘wvopwieur — vo) anor ema earetyoud "apiuoxo op “tae eoind e a “ood ‘aug one ap woness yh 9S =!0q20 ‘ba yoopeaur H yooHoGRT oF 2p 2 jRINPNTO mEMP s0[eprordo ig je0d tog 270p ap prempice a jprcerant eamsoloy “arezopasdns op aferrespiraiel este un fectr I impor fant atunci céad este neossert cresicies ddozei entra realizarea analgeziel inti, ‘resteres presi mice, ispee (la asmat papa ca incipslelor analgezice oploide opiotat | Ester Tine |For dete) tat Ale covoeeries Speci Riera 7 pin tet Higemocionl] ee eisne 5 Netadoat || me | me | aS |e Feaasccid” | opanag PO mg TO me] 35] stat odeat cu stare de suxietate agisje, morniaa evideniaas un ef deriv gt anviansios marest, ou © suanjé de exforie, Deprinarea respiratorie spare de le dozele terapentice sf exe potericd fa cle CCresterea presiuai biliae este mei Ia 1S inute de la injstates ioiramuectlard Hipotanstunea ort jamie medin este ‘Mortian ese indicatl penieu irezcmen- rinse fae $ mp gi 30 mg, I intervele Ge 46 ore, sub forme de solos saa a comprimate fe ox Gath. Unccs! se inzoduc insrareca! 10:30 img ls fecace 4 ore. Inecile punt de ales {i anumite cana de dover! acute 91 18 condi de urgeuil. Dozsle uouale sunt de oteaja este rel fale, daca oral echianalgetich find de 5- (nai ales de albamint) se face fn pro- ponje de ciret 35%. Concentrajia plas- Imatick medie, care eorespunde azalgeziel fvte de 65 agi (Gar variafile spare de discbuie este de 3-4 Ug. Mor- ea) sunt de 20 mg o dati gi 60 mg ta 107sLeor Io (ero 2729) a8 ne oxoang pow ymnoye mijaed greso aqeo adsso4o) spyolde. Home 2fe PASTAIEAED 635959 sypssomes 2 FROIN s7a5 Ul [arto aye Shogp ‘evoydiowointy) euosouioapifL laNiguoH BUVOLYNYHES¥ 310343 NO BdOIdO SOMaOTWNY aLty ets? wut otop of ands medics x 95 spats qagsou Bor og «Doe! so 3p veted ste deo der sseriastosre fammacsloge sos, ve exeingh etal Pore este compart mich. Dowdle composi once “peperis otic penta solgert ~ 100 mp to ‘Efectul, mai rapid decd! peat morfia, este maxim la cires 1 or Dozele mic, folosite obi ioral, depeind putin respira cbianalgerice “deprimaree cat pres de orb Rareori 36 Ee sald de doze uzuale Suptratoare. Spe deosebie de morfink pe- ‘dina provoack mideians. “Aeilitses ulema my este practic in- ‘ivenygta Folosires tn cimpul tavaliuh - nu implick sseuri ta perspectivl pent fepll desi now ndeoutl poste prezenta Us oor paar inferior, Petidina, administra oral, prezinis © Diodisponbilitate sistemicd de aproxima- Sy 50%, Concent satich maxim cst realizata fa 1-2 ore. Se leagl de pro- efectuli wai puyin durabil, care ov per 2 organised ica 6% din pets se Tort nemo fons crested fe 28% cfd sei, Tale sidelor, Asociezea oo MAO poste fi ue de aah oe ‘Metadona (methadone, dolophine, hepta- non, sitalgon) est un compus de sintezt ch acfionaea receptorilor opioinl, respec- proprietlile famacclogice d= dip opi id agonist. Metniona are efecr analgesic tens. Potenja este egelé su acess © morfinel in cami} inject intamusculere. Raportel inte dozele sfcace In injeste intramae- Capito “Anetenicele generale” asssosoe oo winoentge 2p [mp puppy ereumoe seyeadqume 9 azn FEHUIS op sfordo sown ¥ FORD wsiaans ~ 91 “FLT 5 ne eas sas sey ‘ommgoer dx zp pivapuadsp wos tam op ywoswr aid toposeetneg sored 3 How 5% uconnued t yore pd =} poset soma yan Oy Se <6) 3 _, ES (ee? we” So (* reese | . ol [eC 3 in rosin Me unewan0 ora S anepoe woope iw "wOGOE BD LN ton ah) send vevie Siond_ond 4 0-9 Se So 4#2009 ‘anved yrveaypa o¢ SpReioweaxec Oo RRR sno} eo so sno maoad done ae oud “nayos ag pF oTeaa9 woe in 9p sfotop nom Fy “splordo ned 2p jewospas goepmet op spe azud phy " ope ant " yan Bp boo oy WAG ase oye TT UE ee amo nNoad yo9p HK finde ~ jue] eer ginonjono phusuysgo 2p 7/1 op sie WED EMIToie, peat in pet Tolosi doze r, = manifest prin erey- Serial pulmonse a |e smartinoman. fate sd nu trebuie 3 depigease’ 600 mg. cia te persele nb 45.2. PENTAZOGINA (opioide cu actiuni complexe) pentrt analgez fend intauniscalaro doz wnick de 30 mg fan iatravenos 20 mg (epetind, 1s ne- vie, dup 2-3 on entezaciza mu este ecomandabild pen- Acct gut de aac, F tru tatamental ducer fe tare tai slab dectt peatra penta } Imiocard, deoarece efectele sale hemedi- zocing, iar acfiunes antegonist® esupre fee sual defavorebile to accaetd si- receprorilor p este mal pulemick Douwsina ete folosith ca analgeaic Se decyoia tolerant este pentru combettres durerilor acu Se injecteetl atramuscular 10 mg san find dupi ueveie ‘mi sunt de 30-100 ug/ml, cele toxice de 200 ng/ml, cele letal= de 300 agiml. Vo- spritea morfinci san ltor opicide asema- dent la mor- pendeaft, fzied. Poate declanga sindromul de abstinent la morfinoman. ‘unui efect analgozic comparabil 210 mg morfng, injectats, este secesard o dex oralf mare de pentaro- clan = 180 mg. cemice se preferd vali ~ medicament ened intramuscular saa inteven0= 1082 1083Wem a[e20c] “yar fem nes) sIREID E02 taxing “210 9-9 why weds cod 2° ath, ¥o-z0 “ning Jeode '=9 guodmes 23 am op Bay ‘of poxdaoos op ley pana arene 2 ‘arugiout 2p leabap tn eovonmere ap (21¢ -2Bue) “suydiousidag) wuygrounadng, ldo nO vinov viLyO ‘Gout no aiferdatos a “310 fre dnp m NL LOGUNY vo lis ‘das aod o {(02) sotonany 80 59, ocameap) Foosopet op eed Eewwofmar see suoqsiear amma] -qne 8M OY 3p 29 i fi ‘yup er sory an aBuye~ eTop m2 ns onpouT sua es(Phe ohah Nsioxond OS LR 0 on soos Fig, 217 ~ Suuctra cit « nalovone nao sunt autegoni pentezociat Este declang pil asemaitcare celor ale pentazocins! — fanslgezi, sedare, deprimare respiratorio, analgezice Moradet (ICN-Galeniks, Vagos ole 2 mg/l mi 1 Anglia), eps. 50.mg, Hidromorjon (Sicomed, Romtaia), ole 0.2 malt mi Meradent Sintalgon (Sicomed, Romtuia), epr 25 mg Mori Doliard (Nycomed, Danemarea), ope et 10 mg, 30 mg, 60 Morfind (Sicomed, Romsia), fiole 20 mgit al ross fmbilisle 1-2 mg Nalbutina 15 mg a W/4 de ore Toaintea aspen, iar pentru tatament se injecteath fa veaa Mubais (Dupont, Germania), fiole ipidotor (Richter, Ungaria), fole Tramadol Opioide folosite ca antidot Nalorfint Nalorphine (SERB. Franip), ficle 10801 eng poor ote “airesd “ypons sama 16 sorefjeus asaya me ouorourouuo Deane outa i Go » ges somasmmpe pap spec SF opeaeer laos “spierde aojemem gecko [iso DER “MOMMA 2p ais0 2208040 sa Sigyaun 1 ronaaidaun "22723you0 Sneed “ond yeesuine sjusuroqpout 9p ats Q ey 8 gondeand se Op "Eee ned eSPENA Ty BSS ENTE: (Rp squad op meso soon. uj 12 -odgy aowsaucu uaisurecm ¥ oxo} s Myonviwianmny 1S 301 Soeaye y ied speomiadnay ‘Tetop warmed -owd wuqoTpom stlesorep as mgrd “EMIdLLNY STZOIZSDTVNY “13 anoopsp eacogiyey ~ SHIMON NPIS Gp soon 0 urmiog wy ue TEOUTGaY | Rea DnNOd «4 RUSE Sadger oyorceas ope], e2yond ammo 0 vane # sepia \ [epiomotong ap cienetaras ‘ove ie so[ouoounm-y souwreurive "une |) -pyan memrarepuie 2p sngesoep 9 yfndazoo ~ acoueqpem east — Ttnead) npposnd poreunynn® 2 * Tamme apyieudaad goIOpard und ‘moouajopayp ‘praxoudou ‘fmeford “ony ernuope unas Exe. «| op ~ syusemorpat ane ane “hve oo eowogo wifed uns sep oon S gnop stymeand YGIOLVINNSY WLIELUVIIOd NI yolsloads SNALLOV NO JTALNANVOIGSW ‘ANSIGIOUSLSAN JWHOLVIVTANILLNY 1§ FTAOMAUIdLINY “FTSOIZIONWNV ‘97 1g 2ieod > quae up “sesianonEss rns ‘asgay aqpoyetag vaqdepe [or no sscoaxt SInSRP woreypeae eo asasojoy 20 25450admaistesst acid sostileatciie primal > rind, persoancle cu boala corondriant, Lz ‘pila anipietice. Accatea sceaal ceazioal anal fo cute so ‘Acjiuass de iabibare a inflamatiel poste fi dovedité experimental, folosind ciroulafia fo sinoval8 (mdsuraté pria tr tori radioactivi ~ xenon, tehnetu), modi- Gili de cobal proyocat prin wlkaviole), fletbile ratiograice, noduli reumatoii Taam (Ge exempl,edetmul earageniie al come Freund, provocath ke sob fara, nei suspeasii de namie, feilbutexona. Aeldul aces bye © poten | testo ‘Giococoricok [ antintamator | 7 Ae. hidroxipare ¥ 1 ¥ Leulotiene Ae, hueeMarehidonie Prostéccne (HET) ' Prostaglendine 2 hidonio. - (HPETE) Endoperosiet cite! rapid inflarnsfis acuta, durerea gfebra gi pet mleyore rscal efssin inimil, dar ouz60 sor (eqmmeqey) gion 16 enandnus sooo seus #8 eenossap fflezos toruied uf Usbit ois PIUTMDON TONS ~ 612 “fz esse: yoru ‘san Pe lh foes eo | — Siew saya’ enudsoo0 ‘eu Sp pisonand Dasaung” ome029H jeznoe vare038 a soppupre|sesosd ost ppmxa 96 wifeoumoy sojeupunyiow at preanstoype a3 aopeuray stonsoape 2qiase see se 5] og ae 9 OREN ‘awed “Ban, a35 nypom Us ad a8 eons 8 appleoybo wresfoenyzeye loucecite, de plachete de ‘iliaflamatoriy, dat Hare wile wrspeaic Penira tratamentele de soar durati antinfla. ag Saranac let enlae| oe au ve ‘active numai dup absorbjie, prin metsbo- eee efi tec, nck Iizere, diminvest’ fe oarcsere mAsura pote 1 fenomenele de italic gastric ‘ist atic Gdns ea Se ‘Rigoul ulcerigea facut ca antinfae Jade sa test) Mijee ea 8 Be 1 ‘ito foidetes pemaeas) | Reso wnaflaclde Seta sel ge Se (all also adn Medizanentol cu’ cel gsi sane Hse in cind au doveait iaganibile sntulercase 1094 103sSomes a) amlaaprsa 0s ne ctoeds de ea oon aauouare SomOnIRED aod -gsvoso wrqsose) yee=e geet ues) errad “sueyoyyu wlosnoy que yaaa op sfvames sernurmp Tapa =p our nroanp 6 vpfesed ataBianaud Tats es oe ORURS2fuIN ets axeP soon ANIGT MSR E-7 Bec UOT songuas} ned greoma: (ear mp ‘dnd aiesoe UP ojestayest som24 ciclconigenaza plat I de sioieza tromboxat lip prostaglaudinie ow proprietii fagiegante plachetare). Pears dozele msi in principal prin coujugere ca alic- ts nna, rezslténd acld solicilurics se. for ieee eee eee fieazd, de esemenen, deriva glucuroaici Fig, 20 ~ 1098‘wnoqfor =p fauna gas mROKOUND “219 aidan sp ‘cuomr sop caomonay poem“ poeoi03d “roveneie stop 2p andon ston spuatoyed op ~ sdgjoa ues apse =] ayyipaco op “oieseurs ysor ny TE | ‘jpenodues) soyaése anaed 2 ase eereiaBugg “efuoun =p yeas 4 ceed preBeaepy, sorpItd 2p “yn 00E 9p Hog “waeujog MP BOL FOND HI sente8ip rpceSuge ops pwumustep =m 23s srenuntes of nese 20,429TP costoperato, ca gi pentrs combatersa Ca gi acca aoaisaiite poste proven irexie. Dovel vecomaadate sunt de Alozele terageutice muri micgoreea4 elimi i de sar trebuie evitte. Folosirea cc tabicanie gi cienov, i muszalere, halseina, Uneeri se produc ‘hem datorte deprimarii foratci! protrer 46.1.2, ANALGEZICELE ANTIPIRE- TICE DIN GRUPA P-AMINO- FENOLULUT 1103 1102ane - sujamrpsce soroepus ~ pon xno eon“ Gatco poe mame op Crane Iprmmooar or “wopera®” ang 3p ie Bago, pons up son op omer 2 TRIVRtie “ercesspcont © om oe rete i srcop op nies eifeaneones Wipe) © SENS SANS TE Bd ey | "yNOIGNIOr yNOTOZvuld 3a aes ebor qeoranioy we opten 20 © nya Ca $Bu ogy ane 3 pia we © wat pms woop ee ERTS oe eee 1 | hea Sep “pea seoar zasagert 4robe Propifenazona (propyphenczone, ciba- este un derivat fenszoaci. Are 600 mig de 3 ori ponte provacs erupii euauate, foarte rar lengice severe: sindrom Stevens- & si slngertal proape ters Feaazone se aéminisves24 obiga ral, 300-500 mg o dat, rd a dept ¢ g smo- plasmatice, ifueeats repede fa Bus ia mejeritate motabolizatd, 40 ua oe rcot nn ‘ain a oon on WHOM, 0% =04H,0H (eae sale ee Cy O Oy ° slab decét cel al acidului acetilsalicilic; Foibunent Oscars Arnpropazont important, Dozele terepevtice au actiune (Gozsie isi pot reine ‘Pg, 222 Suostor chmicl s unoranalgtzie anipstice gf antioflamatos din grope prwldioace mr scone, administra oral, 2 ab- soarbe in propor de 80-100% $f real 1106 107sort sort = “yours? oven poor posouord “01 GRE ui ssweaps soqnfoear eluanooyy "tore -rqnay woap puevodas aug Fur a “I OL woeeas " “859 we ane rae, “(onde 0 ‘Bax Gaz) ete ‘soqejea sume jRuOWeOO) arestadwonep sotfde oieod gowtpars pool 3 weyaines 2p 5290p 1S 9 sand enusou0D Brees sonpay wud speed 4ceatapate alergice, Ricca! ° find de 98%, rexpectiv 80%. Concentra 7 este tneh mic, Este cou- glssmaticd este maximt ls énnaistares orca, cove mal tr: seaati canta oe depégese 5 ual. Volural d= media este de 0.26 Ug. Pa 46.1.4. ACIZII INDOLACETICI $I ANAL {posi de inflamafii conges cexperimentale pra. clavicle, inne mareats, efieace fa rita rewmatoidd §. 33 probabil vasomotoie. Useert ie confuzivl {ow sine bolnen. Uneon 4 svanajoet edinnrarce unl #030 ode fn 24 de ore, sera la cleae, eos te pele Hei dive on bud peste noapie sh reduceree redort ( Probececidal micgoeanl excrefe Teuala & readied cst bane, Pies mass lose aah mitaod 96 sume ep our gf (nme. 31 ~ Sur op — mind wan wjbus og HSad=p 6) wrevar vhvazognany op 16 (210 (3) "30 Srp 9p 2189 2H 20 9 2p dan suorodowod on eeoryeat yes0 Ear g0}-0oe &P W2OKT “EE aend TAALICD 0 jopore) TeDEIOPO aut a (gored soqpon edost csp seamrosnese qoseamtgniny foun © poems winsang ~ Eze Ry “ i vecoho“g Orr = = eH . :Flurbiprofenul (furbiprofen, cebutid, TABELUL CHLIV mare de 80%, Se leagt de protcnsleplas- mratice fa propertie de 99%, dar oeupl sesenvennd Bapoten Naproxen Disioenae a Balenamie oni> de 99% de protsinele plasmatice, Conceauafile plasmatice realizate prin + adminiatreres rpetath de doze terapentice 2 ugiml iar cen fo lcbidul ie, 2 condi; expesiment la bolnavii ca polieritd se absoabe repede ctnd at oral, resinind concen A maxims in mai putin de iatce sislemiek exte mi necesacd prodeaih le fntccedente Wloerosse. Decl apar ide vedere aub tvalament, tebaie tua examen oflaimologic complet. ine supra. Pao fe rect advene sat mat Recvensau opsouge re 1 ucrdsti fa) Fone Jonze vdRsé wp cxaproisssd oie;uay sain Y PUN emoES — per “hy 2 aN tooo {O)-0-heno ho veocte-{0) a (%o) che : g —O® ——_gOlO | SD yo i Cd wajoudngy veeae-XO){O) soay-(O)rort 4 48 sims ofoczand wy plosprad pessoa a (msaipiy acorn “plejouTos gO 200 aNpO1d 25 [REORIA) “za sordjuencies poe um “2u2sjou wojiew ‘giea® “qpeaee® sgesompin — Wwordous! ‘exfosdour)) yweayosdouog

Ny yproramar eunwyed ep soreioeet =P esaruodie Sun SPST pen memo yj conpedounar eased verde unduy aro 2/8 7 oid‘Alka-Seltzer Bayer, Germania), epr cf, 300 mg ‘pase 10, 200, $00, 100, ie Dahise, racpl alnegice seve. 46.2.4, METOTAEXATUL $1 ALTE OITOTOXICE ef. 325 mg, 500 mg Aminofonozont “Aminofenazond (Sicomed, Romtois), ‘ep. 100 mag, 300 mg Mezamizol yecalnin (Antibiotics, Roméaie), 8 meatine eel puis 2 ah sub In cazal fateruperit admin pr. 500 mg Meramizl sodie (Biognesie, Roma), MEDICAMENTE ANALGEZICE, ANTIPIRETICE $1 ANTIINELAMATORI upon. 1 g, fole 1 g2 ml, 25 683m i NESTEROIDIENE, MEDICAMENTE CU ACTIUNE SPECIFICA Hovalgin Hue Hoctst, Tce) op POLIARTRITA REUMATOIDA, | Anaigezioe ~ antipiretice’” Acid acerlisaelic (Sante, Roma pe. 500 me. Noveminotulphon sodium (Reaaucin, lille tamponat (Arie op ee Novamizel (Mustafa. Nevzat, Ture), 300 mg? ml Optaigin (Tes, IsreD), opt. 500 mg ‘eis acest (Acne Siam, Romisis) epc 100 mg. 300 mg, 500 mg cpr. $00 mg, opr. ef. S00 mg, pulb susp. 50mg, 125 mg, 250 mg, Bferaigan (Upes, Franya), opr ef. 500 mg, palb. ef, 60 mg, 150 me, sspor. 60 mg (nourisson), 150 mg Geune enfant), 300 mg {grand enfant), 600} cope, mast. #0 iol (Nordfarm, Remini), Farmadef, Labormed, Santa, Sicomed, Siatoferm gi Vitalla, Romi), ep. ‘500 mg : Paracetomol (Pharmex, Rominis), ep ‘max. 80 73, Paracetamol (CT Aranciatittel, Ger- Paracetamol (Bellona, Roméais), sspoz. 125 my Paracetamol (Antibiotics, Biogalenica, Noraferm, Pharmarom i Promazom, spor. 124 mg, 250 mg Paramol (Fermacom, Roménia), pe. 500 mg Sifenol80 Sita, Turcia), epe. 80 me Tylewol era strenght (Mic Neil, SUA), ope fm. 500 mg a1ectr x og so top “emg song i OF do (aang ‘sapeET mETY) wMEeIE Gag nn ap anesion epoaen aa oe toe er cae ado ener edoameii, BOOS) OOF “OOE wo=mat conenng sec 0 pi “tay so Yommy “poussins 7 cians Tiooprowey ado “(aay “pouINULENS) wroydoay sa oot ats peace Ao tepemmy epng MS ea cdo “(eomy, “243q) louposey Bar oF sr of do “expan “APBD sesory MEMOS “SoROTETEY) ‘fr oot un og "Ba sx “zodes Be Oe “Be ge ip ‘Grfona“K6!2G-e@) uoeny04 ‘Ba oot sd “(mpmiog, “eaERG) waconoA fe 06 2109 ‘Bu ozt “Bax 09 zodne ‘ga og “8B “(emsny emp) muna Sut og “801 sz “ato “tony ‘odomnery, yorss) ommfios . 3H cot yet ado “Bes og my “ado oujsoda mjowey proms py { empwoy “emuon) 20 3 or zozns Sur sx “0 “ODE ‘bur gs “todne ens 20K “BIER-NDD eAlomna 61 8 emgemy SAMS) 1 eee ug odes “ar og "uy a ‘(mepoy "eaea Ty BQ) 2 ‘er oot zodas “ees. 6 wots) por 20 (Gmpaoy eye) por 20u2/ ‘tar oc “fp ‘ormrmoy "wp: worpawoug) syper omuajorg zert ast ymais soueforna soubor ce RE 8 OF so (amyaoy “sepelaRey) sekajong 35: cor ode ‘(sqtny ‘oosmaaig REALE MoE eOY) eh $0 op] "odns "Burg "Ba eg as ‘oprany Momp- mney) sooo acd “empioy semas para) eae ‘u og “odes meng BY IQ) ED Woe scorer 3a oot ‘rode ‘QdiBg ‘oamag) smydopocr ‘1 ee “emma ‘foanmemry ones) Fou $01 sade 05 se sls nai Soups 6 ado epain ‘ousg ems) sodoioy Ye RUDD "ur ogz so "Eraton (KREA, Slovenia), eps. Aurosiomalar de sod 10 mg, 20 me Myecriin (May & Bakes, Anglia), Fasos (aktiv Arzasimitel, Germania), Clorochinat (Chioroguine (Ralet, Chemical, Belge), Pooxicam’ (eleor, Rom@sia), opr 20 mg, 40 mg, supoe, 40 mg Piroxicom (Autibitice, » Romi ‘Hliroxiclorochin (Sicomed, Romfsis), 4, 200 mg Peniclamina . ‘Ariamin (Biochemie, Austis), opr 100 me, 250 mg Cuprenil Polis, Polonia), epr. fn, 250 mg Disizmave (Lily, Anglia) epr. 125 mg, pr fm. 20 mg, ac. inj, 20 me Tenokedl CEezscibasl, “Turcia), ops. Compus! de aur Aranofin ‘Auropan (EREA, Slo 25 mg reson (Orion, Filands), opr. 2.5 mg cpr 3 mg Trislan CLemery, Mente), opr. 2.3 8 134 BIBLIOGRAFIE “ast Mi anor RS. ~ Rocsousiestéis — Us sussron 2. ~ Nonserodal mulaanastery Be Med 0s Soa 8, rpden Rly Beet BC. ec = ary sovew ffs garcscsogel proper "Wcefeote we bs teumatit arate Drop,tet ripmg ‘for poneisoone snpflosde © gon areo “areyouaNca 227A; pms oy SLOD 2 dard uopioun sopumeiaurp vat ‘amu [osyy “aEMss sng Saf TD 3p ‘ome sep ‘soeoujane mat =P UEP fou “ye pour tas 3s sep "sideore spe sraoyptle ys aqedea slumisqns wns ‘yolownsu 20st STaAISAudSCONNMI “ASVOUFONVOLLNY F1331dVYSLOIIHO “Ly- Wan rad ye §) mx tatgext SRUEDEPeNG LoROROTAAEE BARAT ssiouun sopseo “anzodums# sqpos 91 sausuprase yfexpeouy yons ast auoBere> sods wo sonoigne sorusduoumxonay ‘suofeu epuicns aie Seni Sten ade one 8 ped STANIMIOINAd “6h neh wteong omery eA Posie ae Moponoy = Beg“) EMET—_ fen eae olf se -sioarl, find eficace gi fatd de baci Ide receptort acylonal. Meaiiaa- exenipla, so flzcazi aumal de re- BBP 2, ceca ce fl face mai activ ou pees {dha poleculd D-slanina). Datonié ana le co porjnca terminalé ‘Dealarink @ pentapeptide, pe Mig. 240 ~ Peotale celle $ membrana choplumict tn cars) Yactelorgram-porkiv (A) st “pannel 127ore susnsogy ue sigs Ubu en op of susie woot, ‘3 aS op siaszaid wud Teoeno oi pomp! enV lume ngued yoouo0 {UE USKOTSS srcuy joend “Sire consuore pam} ojo Tn2so ET Gp und yon op way sumioieed wf 2018 aimepsoeize To spumosias UP S1-0k ape 2p sTe8TE “= smeP Soonftu joel ~ 2408 Doyes ae a SOUT Tes Tpatesd a9. aBfe0o 38 sopoid Tap tee Teauonsy sousuese 2p genes mimvodu Jur ooo U=UUISH PS SOHNE aS Eoin pinzow 2p y0vs =uyfored 2P orupe sored =p 9299 op sie 1weURopatd PTS 1 sojemnrasd eae perch eamTeaUl #9 208 22 ‘copay “ptoaned wamsenpy sono gos sued sou 1p 2 OT “agen “siemayase mus pooonosd yo vemneymmpy “els aman 26200 OP " od yr ng a9 “27291 Drouquow sumed wrzasd (sitar Sr nse aquine 05g [8p “308 21021 fue so payee ad sieonequmpe oF pegs ome OT Sevtono spe eazenetwampe dtp ware, "yseodsyp e200 op “en Isp auton 9 itrraid aouewoovoues aploiauderg “ens Spo owhisD rououopnasg #8 20904 sa “ootiomyus smdows jon 2104 am | | | agamny “Cie Sim napods no afaeypyeed & wueTad froslergie pesicilinice (cree €0% din toishl peutied peniclizel, ev prudeny. Mai ale eI ach bc pHs “Fig, 247 ~ Sirestce. chino «principales pening, waieat sp ap yaozede wmnyon tn no “Trego “grag asuydeo tars yo gie=ce Of uowynywasy nuioads no anMiDINad arty i$ variowadtiZNag “ler mousse phe op sareneTope yInh ow2 souamS ye yompieed no seamen ap oz Sods no aeamed oq 2p HEM! a20p WoUSuaty “ofa mend sedi © ete RNS CD) 1 A BEET __., : ena ee | a Bio Fin tio, pe on sen : Ps Fo Fao So—n ON 8 i scene zone EG) 009 OL raaemn 009 =O) evaces wees = a nosy | -HO nay PRONE ae ‘ratedwet at ypsaop v3 amo poyporoed emt segisode omnsquicur ce spied end “Rega 2 = Fouulopron "2 ee ‘muassiay) — aqnSou-uress ford op ssnper THFF2| epsofona nop ae ienuzouco ap eareyso1 ro "yma feo eeoopaed ony a vn “ais $ syovempd ares 2p aznso wp ertcanpe 2p psofon any gus aaosoyey og -euMPIEAdNem. - 2} Weep Ue Wor waco soneuseld ‘rep-00n9 EBAY stagie ZoqaTaoq wyoctoxd and 1 e020 “ge iy oreed seqioredquampxoreg “22709 Dau 2 ead 7 nmr gy © mt“ oy ase oxfam ap rer “Heourpou 8 wo} One OF ML ANE "HTS oT eaopend sou 28 womviiny 20% ‘sreusiord ep 08 2p =itodord ag (W/E ¢ ep EDM goneM -s9jd axfanazotoo 0 WO © asad panp 8 2p unPot "edard ojoon naigad ad sfeasst | Ty zo Prioweed nog WBodap 25 “8 ponpmcayzaeg naywod "pein ono wateri Dea eal te 24 gh Ou * Gecvenie deofl pentta slic antiblotice spariniad aceleigi arope. A de proteiacle plesmatice 8a pro ‘ok Este epucall predominant pin climinsre reneld. Timpal de foju- siitjre meio este do 42 mute Folosesle sub formé de sere sodic, {injec intramesculre 500 mg iaiervals de 8 ore. Ta infecfileoezt op @ 5 wren fa 09g 2p scp ow ganseuoasy gone ever wsaeynony “a Te ao, 35 ze 5 cote and rn wes ti T oe mama |p jong | pacman a0 pd waayi maya so2 9p Hey THOWUIHNY SONS y rape na snefoumesd 6 aprzods nJeig‘22oUpoyued samp mised arc TaTaseGe asm csv Citiva parametsi farmacoeinetict pentra diterite peniitine posta Tae Reece apa 49.4. PENICILINELE CU SPECTRU LAnGI ACTIVE FATA DE PSEUDOMONAS teal wii, dar saat mari - batziipenciinel. Inbiba, de asemence, parte din tlpinilo unor becili gram-nega- tiv mas Intresul ‘meceaismul find cel cu- fe are ageatal cauzal obigauit anion, germen decechit de pe- ‘ntipseedomonas) inactveaz’ aminoglico- jamal a 25 pall, Bacli gtam-poritiy r8s- dele de vitro. . pand la CMM cuprinse Tae 05 pg/al nfuenasesect pre 18 sojrso afe separ -raopge opplaeyay up amonndas arpsr “ Gramiga 93 my "Povo aneoutou ‘ye assce Moor "300 9 ef rooney 18 ByBur oye aitozyne am — aera baler te ‘Bef 8480 Qos 00T =P Wee svpsEEIO=E j 2g noemiesuioN2 BPA 2 azo} qa ata if youmpenaqms amowuyaess sqotdare je oyoresssd bsp49.8, PENICILINELE ACTIVE INDEOSEBI FATA DE ENTEROBACTERIACEE Procain benclpentilint ‘Bftard (Astibiotce, Rania), fle 1 600 000 ui, Fenaximesiipenelina (potas, b (Cliacit (Turk Hoechst, Tuc)sect -paoy ‘oe mmqion 36 areaiosON) Ose ‘Se? wyroumoyy TE g/80! Sct “den ey “(ee05D "wana a ‘owey fw ons Bu ose -séo “oied) waco Te s/c st “deus “gd "Ses cos ‘ado! (aig “EIDOPSA). weINON 1 g/m ose tan 8c ect done aed ‘oqesy “HUE Tegcma) zououdrar 1 Sci “dns “ap “eso ‘dae ose Te a ‘gm sim gx des “and “Bat opt “fu gos "Sar ogy "ha gzt “alo Set ose #80 “epg “spn FE 6/8 osc os ‘qn (ads cama) cueqosag ous len) Tear si scr deus “aS “epee voungg surg) ieyosoury s/t 052 “din og ‘fm ose ‘sda “BID of pa ps fe own Ta 58a 18a densa scristegse “= camypsog SHE AES) “erapuoR, vangiomg # etaiy) puyosouy fe iter ‘cemmmoy ‘Sneigney rwosqosag 20H | sills) Soesfmp001 ‘Sur ova cos ga as og sits sya 0s Bu 90g/8 y “Fw osei8 © fr aI agey SUPT Giekse) apemny “eymoy amb ‘sts8ing “2p0RgHOY) srewe2e} 2199 9p powaINu} no miosoose AIS -njoul "seuowopnasdyue 3 | Bu os ter and “one aambs smipetomuE) upydaisoug J e0 83 ose ‘fo “(@emMOy ‘eTeIy) peANDD=O Gu pos) -tmeg "UR: 3 fay ong ur gw ose “dons gin Sur oe ado“50. CEFALOSPORINELE, CARBAPENEMIL $I MONOBACTAMIL acest capitol sunt copciue ais on- groper metilea fa Jeculafomulei de sult Ubionice bets lectanice Sect pesiitacl, a pene CGiloporinele a act acerca a gf pealclizele ele actioneaed asupce 50.1. CEFALOSPORINELE $1 ALTE ANTIBIOTICE INRUDITE, Cefalosporiaele seu cefemele scot ¢ ‘gupl de anbiorice bes lactanice, Pca ~ eaprinde o bunt parts dia cocl! gram po- ahi, Stftococal auria, inclusty tudpinile enielinaao-poaitt, sueptocceul piogen # ‘pucumccocl sunt foarte semili ~ CAlly* tind © in vivo exte de 0,1.0.2 pg/ml. Stailoccei * Consent nnd intibioar penta 90% din tp 1280 T cleo Catal s Cafe wort Cetamands} A Cetoaxind o (7% Capra Soot Cofmaond en. ‘etd 7 enincetloporane Saalsnorina 95 gatas mort Goce ot Ne Soon ‘eld 7 eos -aminceltoparano Satan side’, 0. Latamofex ey oO TA Tow Ai tox P-matoxé7-aminocstaoeporanio “Fig. 262, ~ Noclal de baat el cefalnpovnelor gal aloe enbctce tarde chins van02 3 “soquounoud opesgeny ‘aueeu 1 feat ap maton neounees ype, FW EC agiesoass wip (oupmawy sopoiques ve B) spanodsoRD maxts araevcarl inject intravencase. rea 0.1.1. eenoeroanse DIN GENERATIA 1 Yegstereazd varias K scivd) (ere pot determina © sodderewet arto tarsevs ‘ammasmenay loot "meu mes exec} 2p WINS) qa =HoeaTe} 25 Be ¥ Mfewoued wip sojsutiodeoTe 9 ‘so g'0 sp ates oneamsed Indi ‘apy op sthodard ay sogemeeye ‘reusiond 3p weal 35 “Tet soimea snpraspide “dong cmied (6/84 | 2p 18 wodasd «novo 6 sosomnaed nto! 10/80 [1g oon vez v vilvusnas. Nig FENWOsSOWs30 HOS 4 2 raya s'c1 =p 3m OSD — ep xiey panoe aviod amr arg ~onpods soso 2p fetous® youd eouontoee 3p Teminde “(rom uses Yoooyse “pupeioo ‘eupoueo) eaypeapso, fro} wus) Wenofey 2 sf Sym oot-se areansmpe boat ofetoq qn gh jun wenucowoo papayas “pse7ngra "Neo ar Qog anaad ‘pay g op FUSE vases. aiesusouo> anetOrape tT 1 wdap yateaeat Sw ose 2p e26¢] 8 Sy8e ops ‘evoyosfun as foo e7 peta aman sop ancy TORAIIU presueAe yyeESy uD "gnaw oy #9 =p 1eetocpyy "geval tne wed reomopsd gens arg aio 01-6 HANoe oUesITsOnDD ‘nig cnfet op mndusy “y69 =p sfisodosd oy soneused opuisiosd op yea] 25 -Tay%H { Oci-05 2 onemeerd: jae an ese suet geeoneuenny oeengad wy ysnpont op esses + “ees yogrEE|S foun» sirjnornuren: ‘eto oes ad gagoee apo eo uo “ozeydea 4/0209) wumoeeey Sr joy Hind ssa “| wfeioue® wp ggeiost ‘uy pepodsonyoo ee ‘aloroh ‘ips 3 nsogdes nada} etsy © “oamatar of 08 5 ‘veo pevsoofan 6 gemstp ade nee 3005 of FES atinos WH OFoe TI snOIqTE 2p 8 1 yrs0nHp af sofeaon waren is dsp "wos ‘woonoid yod (ol € op yt fem “as 9 asd) um sjozeq Srnasigo Sys> me eps n WG B10 9p py Mod Eop “stot ued 2p aso tog 2p oe ‘ap wns srepuemooss syr0ct mgsed es roofer uy oF ‘mur poe, ‘earn no ‘amjnanz=p 3p oad un "ajoe) sare a “sepne eRpOTRIIDinject intravenoase sat. perf Dozsle recomandale ofl (Cefotetanal (cefoveian, apaces, apatf, ceftan, ceftenon) ar propsitefh asemdnd- sare cefovitinel, Hind indicat peatre onl Hs put ponies pi ik spare wind TLoracarbefal se folosegte ix infetit smindtcero celor produce de alte antibio- amice. Poate fl cauzi de tle *. 50.7.9. CEFALOSPORINELE DIN GENERATIA A 3-4 etoarine. exons fran), 20.40 mg figs i, rd = fai in copill sub 6 eal.2 steuuedeeyyea anand repeoey “funrous ‘ap yume ypour sonsuiserd ot Uossopacoud jrcowsie}) (yPXOUEIe, eso yee ad PARSEUT 282 ETOXEIN}2D par Cy wsodens yoo page PUNE “Tonle lope oy pupde sysoumaud op. 2[anze ope Zee amas 1 woEeS I ‘ode 1964 ‘pee eerououopeat Siacdoona gy pRaaid es Gane pooromog on “egos ‘spsdoano| os 207 aero; ‘aheania op ANCE 209 2-2/1 spreyond nated URE ELITE yes ay ORs Op sfrodasd wh sear soret 2p at ap wes s0e0u;2 =P f seem 1 seed sp ‘euodsofeja>.aife seeep. booms pehoe Bind poeta as spe rd ee? Neg ap abiodoud “age 2s YO TRopoLgNTe vo aeaeas ‘papradoe mp “aye und (ea poy sos pede are Gpaopeu oiafee nqao ‘igafee “suotmiacoe3) “nd esjur sup PDIP pe tpera eageam Up THREE “STIS ND Mououped yess "oisoasy sfisoee Sang “age op siodoxd vy seed oat yetesd 2p ¥Beot 25 TH peor (MATE 320 8 BOD | “ose 29 30H" snasonoudsareideg 8 suaBuuufiod soeonasd — 4g © 2p mid ae 2 ie es — vumpenajao omfg iy noad Hypo ds 423209 Dvowaipe vomiseas empe ap ds smiocg unwed [YEN 7 MIDLAS ade 204 “Pts emed pin sfera rexjilor adverse cbigouite, ele recomandate sunt de SOO mg la fe- sunt de 0,06-0,12 pghml, iar pentru cele $15 alle duph oprirea acestaia Piotunle ‘alsolice websis evi, din ceau2a rscafu ‘unor react de itoleranps Provoacy relativ ficvent ciaree. 80.1.4, CEFALOSPORINELE DIN GENERATIA A $A toll, Proteus mirabilis —sect rotwumeosnce 16 ysewveg © oumge smsaNS ~ e9 HE te ype (: vs ii sey erontissor LA] | Hoos ‘9 apnoosteg emo) magne Fameeinag je sper, meoeay veloping mg ayaor 2ds0u%e hood pistmioeg uly 20) 21100f iw, anp & ‘qty vagina 9p woe pn veered ep eorumeous “pms > run! My pany Toowiiad aha puna weasel i 7 aeFD Tauoonse © mudi Be *¢ 1 oplozeuss) ompodsoyyes seh oy weNqorotls JUSKLAES Jon ve iar trae monne 2079 ¥ some, | | ' eoero oto yma om comm oximocemem, ang] Srna | | { ivaNaavauva ‘zoe 150.3, MONOBACTAMI Mouobactamll suat 0 grupl de antiti- Serotia, K prewnonice, CMgg sot mal ‘miel de'? ppl; pentm pile de Serratia, ela, Emerobacer§i Prous rezistente ‘noglicotide CMlyy ust tsk mich de Neisseria, H. influenzae, Branka- Tmpidiobasbece! prea bacterin. Se produc forme elungite de bacterl, care sunt lizae sf mor. “Pigemonamal (sigemonaf, ‘antibiovic mouobacteml, 5, dar au fap do Peeweset yaWoa73s S1avEOOrEIE 1 8a 0s 1 Cm ony oeors VERY MOH ey CemEmO ueioeqouony Su oge/a pg “Bua osci@at ost er ‘uated 1 uousdeqies ceed aig ‘oor Hae frie oy Cemme, ‘song 8 Hefan “TR 273 snip *€ 1 “Bur gos “at Ose puporpeg § fu oe rmyoods) Ml faoieady ‘tt 005 sda “erat0 do (nang ‘sone mi51. AMINOGLICOZIDELE ‘aluoplicozidele. Aci- 261sect ep ameyn ylentoouoo george uswioyd 2190)3f WE 20H} 96 22s0HR ‘yoraets veo ep if) sc oP oe 1 ruraquows id nexk prmuipd 2je F910 soso spippudead onied Rosa: ae ee ape + ees aroma Se ude sunsal ap oe Te oul lace Sad 91g “2oeteud 10) feos waroqnyn ‘dud sqaneeg oma =jproonsoamuny one am vareooe 2p "307 9p seEaDHD oneuseid ong nated nySemxe 2p — PEE fs ae NinasocOuOwCP MEd eee ned ofmijs yescjer gy ars0d muse, , sseq-epmoon ours od qrssayo aeosunyord 3 8 rd mfarsou0o 29 wap a0 essu=> sy Fusad OST ou ob amo pox taf tout "yosusrorg 2 wer eo gener gr0iey 02 | sess fms of 208 sone ists qwooooydans (e=ts8 oy dip sounSoyKoowo ‘hao "¥PER wen Ul 'janeNs oP ous 2[epecorfonqare ~ souedaress erpour "yrionaoone ‘oy pERIOp 20 tena "2000102 dort 1309 SN sary ayoesd yens e “9u "ows0}d0ay¢ congourae © prasczeqnte eonctioy me ee eee oo —‘cut inifel al infectier pneumonice no sovomtale. ‘Aminoglcozidels unt medicamente ea 18, aha, 4 Ap Ranh Ontentintc, wo p0-€, Od Me lanai Ac-H Gmlanisac, Ye, thee BPN G Beet exec, i aes ag Geaiod Beaters} nats neh me 2 Wey, biay-c-my a Se no ) gia Pages Sige = nal orig envy ‘Tobeamicind Anihaah’ Pe : pl Wh any Cobleare, steptomiciza i sai ales ‘burl vesibulee; eg local de sfiane » easbgelar bate- id GLAS Sie foatrceist "od 358) 25 found cesozoq espana ind modeouowuccoyt sqeoume soperanae =p ¥|S0009 Boxer eames navag “9p 2 anu ud "aHOpeHd op 2p attung Froaes ghueoyfosay ro gasuyeg FT Epooetany vatmuodio> soyipou 10d =i we vis vz v wilvean -39 Nia _aaizoorEoNINY ‘any If vlowmiiy "VN owe arp # span of dove amcaly, solv WH Snonee el Spier teem Bee {ap seepuaday 23 2O]PE oesge 5o DeTRpisto> > synod BuDySE WpeROY aie op ¢ = raxeafue ymbigo ypaTwTacat soso “ejourees yams UpsoMETE “Soysenre “aesuesrpau Mp stepaonysouney “osa1e3: feng “BET op oie towne ols rao nowt s esesres orgs wioest 2p 229 squad 22 eogwss soniye lopsesmoes = fuejeemios efaanoaig “yon afar — ye Toodsoqeis ROPERS ER tod ryduexa =p joigue 2p wes frfencaota sp paised) nscoyund of easeade dnp sSieaoBes op BRE 2 eucdnenny “oRpIOSS oF 2a] ro "INTE BIRICOAD v amqusones ap ippides remnetonm ed gresingep RIOEPEU Ba “TREE GE, © IEA Tao ap aura “samconcentrailor plasmatice, Dozele reco ri provociad indeosebi sulburdir vestibu-uct Ju: ayo mp ‘rasoe areoyreetase fin rape “yUoD oy gyouat orfon “aplod ary ‘eomureme8

& wa pop aide] 2p inated ypconiay “S002 soem ‘acooisug “euoun) eupppemey, 2 sctie 2 we Erancop 7 swoeong, sup 9 ou ‘reoussentt wot sop aendad 8 psn & vilvean de “39 NiO BNMTOIOVELEL Liv IS WNMOIOvELaL “F in anfosey d0yorrop od Peotsojsamap 18 3a!Taneu0n com Citeya caracteitctfarmecoctneice pentru tetracilind si doxieelind Genco pases] Toa do Dipatities daps | se mis bee orn | hoe tio inure oe | cede ‘oot toa) m unui timp de Tjomatiie de cia 16 ore. 50 prin uria i 5% prin scaun. Se ‘iminisueaed oral, doze obignutl find de 7 Gy s 23 Goo, ‘one lifluenge relevante asupra flo- rai Bacteriene intastinale, Epurarea mu ste practic influenjaté de area functio- fealizote svat de 3-5 pglsal peatra fesutal polmonar $f secreile respite, 52.1.2. DOXICICLINA $1 MINOGICLI- NA — TETRACICLINE DIN GENERATIA & 2-8 episoodele acute ale brongltelor cronice, in essa sce spsron fut 6 ‘preumosos, eafilocoeal plogen gi in fuensae, c& $1 daorth concentaiel meri ‘eelizate Sa trate gi serepile boogie. [Este de asemcnea indicat tn pnoumenile Acests antibiotics, apatinind generat 1 dous de teraciline, eu © potenyd mai 2 dceleiag dows, velo) plasmatc esto de A earn oae tipice, ca gi tn paeumoniile atipice gro- Concedes | aes a nage hoe pol eee @ cnt in ae ra fag eae aaa A cats et 6 a Teves y ‘unl Comer J.B, Jonas M., Te lines, Med. Clin. N. Amer. Sap progenes 1S caries 1982, "66, 1, 298 - modificat) : cae Paper Space bocrene cur Taxa [Biases [Raoccme [pcan | Capos — @ ‘ Eaneweal |B : i oo Bieta 18 is 1280 | vest ieae eee fg 9p yoru fees doo at ese ojeuyoud 2p 92a} gooey SE Wes! eg iets azop us pooieedog abiodend 9 reqeeowenaen YF fejoomepumsny © yoeNRS wien rz ALT seg fuotos Fon re-ow nzou Fond o-Hv-H9 "pbvor og gpees [ediound lesceserscy nq spores ‘yaypoio( | shasser ized no ouejeut avaid ood "eonaurase op ‘uoxor Sang of ap Stop nus ar egos Wm #0 5) St >P = Woomaanwin 22) Be =D wSmooNEMVHOTN eee PB aa p IEG “49 &PIndust de prezenle aatbioscului. Ase respoasebil de de2- jeaje eaald mu modified seasifica- tiv coneentajia entibiodcelui Ta pestosda perinwial, ca gi ls Bolus cu afectin! he injuatsire este doa Ie adult nu icbuie si depigencd Pp. La nowrascuj a vis ce 2-4 descr betes amaerobe. Tp eprcenie feptlal se adminseast 20 mgfkg i de org obdominolscloranfxiea pox Zia la coi sob spt, 10 mg/kg. eM savior (aoa cle vacant 80. infeogi Acest accident survine raeori ~ fieoveala este de 0,025.00. ~ dar este ‘obigauit Keversibil gi evolucazt adesea eve mai mare la feile. Posogenia probabil idasincracc ‘Ua accident bematopoistic benige, ot re poate apres To cusul tatamentull,emspioy "emg pM oot -=42 “(eye8uq “wjoamg) do “(eyswaEeg “wNOEEEE A) got ado “(een ‘uome Hemme Nosed — soto) dor wicco "Sur 062 “St aD so “oqoemneg ‘prego qucysioct ‘Sat oot “300 comm mee ma) PSO sie (ordi opsuew) suaaser sumoroenet, WOU NJ ALYULSIDaUNL imMMoomasMvUoTS 1§ YOTRNNOIOVELZL VANWO NIG 3OLLOIELINY "ata YF Row 1 sof “ip fos: amide =p at ft} enpal sUat 250 Pon wonansaen = Bir ianioe yALOMas alsvusonals Sinan masiqoan ae Jos 1 cy ey “Cormmmcy “son aur oe “sda "Bor os -oquion mes or yeps yun otoeg “yer/gooe amt oor 7 said Dap HEE Aoypam Eade 1S aNEaLepIs je ate53. ERITROMICINA $I ALTE ANTIBIOTICE MACRO- LIDICE, CLINDAMICINA SI LINCOMICINA, VANCOMICINA SI TEICOPLANINA racrolige sparinind ertromislsa, 22 53.1, ERITROMICINA $1 ALTE ANTIBIOTICE MACROLIDICE ANTIBACTERIENE ~ pentra erttomiciad i clartomi- sink 14 atomi, pentru ezvomiciak 15 ato- 247 ~ Ropicnesaes schomatcd ¢ sr3e- ‘Hisomieuett Aw ine aetoale (aos i gonococi sunt rezstente Numézul tlpiallor restSpiramicina (spiramyein, rowwmyeine) nulid) est 0 macrolidt serisntetieg re- macrofage 1 leucoclte ~ ceca ce crest sfcscisiea in infect cu germeni ca Le {lonelle sax Chlamidio, oare se pot dea- ‘olta micina ~ nivel plasmatie medin duph 2 ore de Je adminis: fares 2 150 mg sete de ‘Absorbia au este modifict ral pulmouar este de 5,6 yg/al Ie 6 or dup o dont de 150 mg (ft de 42 us 1992 , Wromicial). Se climint nemedifioats iy dup 3 ore de la administraree a 1g exi- te infest mise sexu, plodemite Dine suport. Freo oot globald a rescilor adverse este de cites 4%, iar a eelor care obligi la opti twatamentul de mai puiia de 1%, Poste provoca greaif, vomi, ducri fh cregterea trecdtosre foarte rar epautd cole 1 macrolide mizegte riecul accidentelee igchemsioe cindex scociarl ce ergotaii Divitromieina (airitiromycine, dm absc), administra oral, se tamsformi iia bidrolizd neewaimatic’, ta ertromi- cilaming activ, To cursul absoxbiil Spootral antibacteian verte yemissior sist al entromicinel Biodispoailitais exte de circa 10% (mai pulin cfnd se nella, Mycoplasma, preummocee, ptoceei Se comporti bactericid falé de “Meobacter leprae Grclusiv cwlpini dapsood gi sifempicint). Este vt macrolidd impouiva Legio if Chlamydia pneumanice. Ce pet ide, acfinea antibacterank Ge pH, eficacitatee find ‘axing i medi alain SS edna awry poi ood Skee suaibncced mee. Se com Ceara emt rofl ite So. SStceje delet cox plated fi ee deed penta elven. Exe door fat de Ho fnjumstijre mediu este de 3-4 ore. Se 'tcnar 36% fo forma nescimbatl replococic, einwita pacumococics, exa- fstbirle acute ele brougtel cronice pro- vyoesle de A influansae, Moraulla i pu aco, ia paeumouille provocate de pnes- terkure avn gj ale micobacterit dec8t M. uberculosts, Se adminisireart eral 250 mg de 2 ori, la mese. In infeotille severe se |, resomandd 500 mg de 2 ofa, timp de tats, Provosc8 ocazional greaié, dissec, duce weer cefalee. Av fe ‘chove cenit de hepatic freslerea enzimelor bepatce. Inente, cum sunt leofllina gi carbama pins. ‘Acitcomlctna (azithromycin, sumamed, ‘Propionibacteria, Clostrilm perfringens, Bacteroides, Ese cfcace ff de micobac- teri allele deoGt MC zaberculosis, Este mai pia activa deodt eritromicina afi de ‘aflococti sensiili la metiilin gi fod ‘Aziromicine admiuisraté oral xe 0 biodieponibilitate medie de 37%, mai (pujja in prezenjp alimentslor. Se acum 1293sett 6c ‘enmpoour steep exlusied axezei0sq ure) 1 eure 1 ermosoy goranae eons — a2 “Hy spoagd 03d mIeQES 3 109 “siso9e 2 neste ewe oy eezepunmg “spt ; amainsip 2g “ah96 op attodoud oy oe %y Hore hy pesmoaun (aoiainvgoonn BOLLOIBLLNY) WHI slwooNIT IS vulOWNIvanIIa “22smyoes lincolnensis. Se abso% fal gastrointestinal incomy pojin ectivs 3 prov Reefs adverse decdt clindamicina, uti pentra esr a fost fnlocuit, ix mare par &p eftre aceaste 53.3. VANCOMICINA $1 TEICOPLANINA {ANTIBIOTICE GLICOPEPTIDICEsect loos) no ep ‘gies yomad wy ped mysip op “pe slestayascy 232 I THB oy osa8Rdon She sopatise[d tetaato9 eons eequ=ct 108 wmissooapuo;doug ‘SousBostoouow ousoirT 5 sect 1 BYRD peel =p ao 0x gays wes qzo00[8 2p arin irged oy piauoyeal | “essizo expsscops uj “ieorpar exe gine | “xfea posenons 7f ssooasan sposeidauts puswasd anuip wom earoqpele navel simejognsm ‘puyds-oiqarso S/d gg-79 ap slenusonos uneds juo 2 HU sz op slozapPREPARATE DE ERITROMICINA, CLINDAMICINA, LINCOMICINA, VANCOMICINA SI TEICOPLANINA INREGISTRATE IN ROMANIA Eritromicina 1 alte macrolide Enghromit forte (Arab Pharm, 5 ml, 400 mg ml Porpiyrocin Qedockemie, Cipr), cpr. 250 mg Propionileriromicind (ICSMCE, sr. susp. 100 1g susp, Wilprafen QMuck, Germania), cpr 500 mg, cusp. 150 mg/S ml Roseromcins Bulli 150 (Roussel, Prone), cps. 4a endocerdita pr rucgadl ou cee le vencomicins. peat emmt acne | Ee Gist, Ungaisy, cps. 250 mg Lncocin "CUpjoba, ‘500 mg, sl. Ia). 600, 1300Vancomycin iydrochtoride ( SUA), fize. inj. 500 mg Vonco-Teva (Teva, lraed, pulb. tof Sanofi Winthrope, Frsni), pe 00 mg Teicoplanind Tovgocld (Merell Dow, Anglia), fas. inj, 200 mg, 400mg iocin (Lilly, SUA), flac. inj. 500 mg, 1 g BIBLIOGRAFIE SELECTIVA arent, Drag, 13,37, 54. POLIMIXINELE $I BACITRACINA (2 produst de Bacilive polsmyss ‘Ate stracturl popeptidct so aed me- ‘cara de cirea 1 000. ‘Spectral antibacterian cuprinés majo visatea.bacililor gram-negativ. E. general 54.1. POLIMIXINELE i BX = Dstt (sistas c= Deu ‘Pp. 249 Sucre chmie8« poinixie! B gl colitis! (schema) 1303Ep eeany que sistojoy <6 “posjemsarenme vomooet ep 39 ip "yopisoe ooy veiendsar unsoyrosnae opyoand ey ned nea Ci de a Saute Sevson Herta otgost -voriuoe loear poor: poeanazg Anes jen no einssyat suatee saaouoa vf soon ‘uauodecy jroeacseIn=ts “ooseT0 ip 50 wR a sed ppaedod op vores mnjiod ey anpasnt st axep oe ue an} Sona Barn 000 S1-000 05 ereeoofut 2s a we 8 Byer Trp) & SPM GO vauaztas alavusorisia + coovoo't “Fa p00. “et 8 ooo se ay “(emety “=on fa 3 A ong00T sa woqiag Boy) 209 VINYWOW Nj BLVELSIOSHM| BNNaNMOd 3a SLvUvaauA