Beruflich Dokumente
Kultur Dokumente
US005256699A
Murphy et al.
[45]
[56]
.
[75]
Invenmrs
References Cited
U.S. PATENT DOCUMENTS
3,558,690
1/1971
England
4,567,178
4,867,985
Towde et a1. . . . . .
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NY.
0255002
0324981
[63]
mm M- Mmhy; Gm R
[22] Filed:
Date of Patent:
5,256,699
OTHER PUBLICATIONS
Pharmaceutical Technology vol. 15, N0. 3, pp. 49-56
(1991).
[30]
Kaiser
[57]
ABs'rRAcr
- [51]
[52]
8 Claims, No Drawings
5,256,699
potassium.
ples.
EXAMPLE 1
Diclofenac free acid, lactose and an aliquot of sodium
croscarmellose are granulated with an aqueous solution
Quantity
mg/tablet
DICLOFENAC
46.5
Microcrystalline Cellulose
100.0
Lactose B?
Sodium Croscarmellose
100.0
21.0
Hydroxypropylmethylcellulose 3 cps
Hydrogenated Castor Oil
Puri?ed Talc
EXAMPLE 2
Tablets are made by the method of Example 1 except
Quantity
mg/tablet
55
0.045
272.365 mg
1.82
1.5
1.5
DICLOFENAC
46.5
Hydroxypropylmethylcellulose 3 cps
Hydrogenated Castor Oil
200.0
18.0
1.82
1.5
Puri?ed Talc
1.5
0.045
269.365 mg
EXAMPLE 3
of the formulation.
5,256,699
Quantity
mg/tablet
following composition.
DICLOFENAC
46.5
Microcrystalline cellulose
Quantity
mg/tablet
DICLOFENAC
46.5
Microcrystalline cellulose
F.D.& C. Red No. 3
F.D.& C. Red No. 3/Al Lake
Blackcurrant Flavour
Sodium saccharin B?
Sodium croscarmellose
Sodium starch glycollate
l58.5
0.3
10
4.4
290 mg
weight.
3. A formulation as claimed in claim 1 in which the
diluent is selected from the group of microcrystalline
Quantity
mg/tablet
46.5
Sodium croscarmellose
Total weight of Tablet
6.0
290.0 mg
Magnesium Stearate
1.5
EXAMPLE 4
Microcrystalline cellulose
0.3
l.3
30.0
2.5
23.2
We claim:
20
DlCLOFENAC
1.3
30.0
2.5
14.5
29.0
1.5
180.2
180.2
0.3
1.3
30.0
2.5
3.0
3.0
23.2
290.0 mg
EXAMPLE 5
following composition.
50
55
65
'
CERTIFICATE OF CORRECTION
PATENTNO.
5,256,699
DATED
INVENTOR(S): Murphy et al
It is certified that error appears in the above-identified patent and that said Letters Patent is hereby
corrected as shown below:
insert -Geigy
Men:
?end W
BRUCE LEHMAN
Arresting O?icer