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THE WORLD PREBIOTIC INGREDIENT MARKET

Science Market Regulation

UBIC
2015
CONSULTING

Marketing Development

Strategy Consulting

Partnership searches

Informations systems

Technical & Competitive Scanning Regulations Manufacturers


This comprehensive report is based on in-depth interviews with food companies completed by a desk review.
It provides for DECISION MAKERS a global understanding of the sector as well as an outlook on its future.

MARKET ANALYSIS

FOOD SEGMENTS

New trends and perspectives


Sales by country and ingredient category
Production volumes by country
Suppliers
Users

Food industry
Functional food
Food supplements

COUNTRIES COVERED

INGREDIENTS COVERED

North America
Western Europe
Asia
Australia New Zealand

Oligosaccharides: Fos, Gos


Inulin
Lactitol
Lactulose
Lactosucrose
Polydextrose

THE WORLD PREBIOTIC INGREDIENT MARKET


OBJECTIVES

INTRODUCTION

MARKET

Food consumption trends


and expectations

Prebiotics are non-digestible food


ingredients that beneficially affect the
digestive process by selectively

Consumer market trends


by food segments

GENERALITIES

stimulating the growth and/or activity of


the colonic microflora.

Prospective
MANUFACTURERS
S

Food industry
orientations
Applications in food
segments
Consumption
RESEARCH

New researches and


new developments

PREBIOTIC PROPERTIES

MAIN TYPES OF PREBIOTICS:

Referring to the concept as defined by the


ISAPP, criteria for classification of an
ingredient as a prebiotic are:

ITF or inulin-type fructans,


lcFOS
or
long-chain
fructooligosaccharides,
GOS or galacto-oligosaccharides,
scGOS
or
short-chain
galactooligosaccharides,
TOS or trans oligosaccharides.

Resistance to gastric acidity, hydrolysis


by digestive enzymes and GIT absorption;
Fermentation by intestinal microflora;
Stimulation of the growth and/or activity
of one or a limited number of intestinal
bacteria beneficially associated with
health and well-being.

These carbohydrates are considered


dietary fibres in many countries.

THE WORLD PREBIOTIC INGREDIENT MARKET


OBJECTIVES

GENERALITIES

MARKET

Food consumption trends


and expectations
Consumer market trends
by food segments
Prospective
MANUFACTURERS
S

Food industry
orientations
Applications in food
segments
Consumption
RESEARCH

New researches and


new developments

As dietary fibre, they decrease faecal


transit time, reduce glycaemia response,
lower blood cholesterol and increase stool
weight. Currently, ITF and GOS are the
compounds most extensively tested in

human trials that have demonstrated their


prebiotic effect as shown by their ability to
change the gut microflora composition after
a short feeding period at reasonably low
doses.

THE WORLD PREBIOTIC INGREDIENT MARKET


OBJECTIVES

GENERALITIES

MARKET

NUTRI-FUNCTIONAL PROPERTIES

Food consumption trends


and expectations
Consumer market trends
by food segments
Prospective
MANUFACTURERS
S

Food industry
orientations
Applications in food
segments
Consumption
RESEARCH

New researches and


new developments

Since two decades, data have been


collected improving our knowledge about
the GIT microbiota composition and
activities through modern techniques of
microbiology and metabolomics.

Scientists are now convinced that feeding


specific food ingredients may selectively
modulate these composition and activities.
Dietary consumption of some of these
specific food ingredients result in
beneficial health effects that may support
improved function and/or reduction of
disease risk claims.

THE WORLD PREBIOTIC INGREDIENT MARKET


OBJECTIVES

MAIN IMPACTS OF PREBIOTICS

MARKET

PREBIOTICS & IMMUNE SYSTEM

Food consumption trends


and expectations
Consumer market trends
by food segments
Prospective
MANUFACTURERS
S

Food industry
orientations
Applications in food
segments
Consumption
RESEARCH

New researches and


new developments

Plausible beneficial effect of prebiotic


ingredients on the immune system through
changes of the gut microbiota.
Limited, yet promising evidence of
immunity modulation
Higher Immunoglobulins A levels in
infants have been shown
More studies addressing the correlation
between changes in the gut microbiota and
changes in immune markers are needed.
PREBIOTIC EFFECTS IN PAEDIATRICS
Two
dietary
non-digestible
oligosaccharides, galactans and ITF, fulfil
the criteria for prebiotic classification.
Available data do not show adverse
effects.
PREBIOTIC EFFECTS IN WEIGHT
MANAGEMENT AND OBESITYRELATED DISORDERS
Prebiotics are supposed to play
beneficial role in appetite regulation.

Some non-digestible carbohydrates or


dietary fibres would modulate gut peptides
production with consequences on appetite,
inflammation and other components of the
metabolic syndrome.
PREBIOTIC EFFECTS AND GASTROINTESTINAL DISORDERS
Prebiotics would fight disturbances
involved in IBS by modulating gut transit,
decrease putrefactive activity, prevent GIT
infections and mitigate inflammatory
responses.
PREBIOTIC EFFECTS AND MINERAL
ABSORPTION
Ingredients with prebiotic effect improve
mineral absorption (mainly Ca) in humans
and animals
ITF & ITF mixes seem the more efficient,
they enhance Ca accretion, bone mineral
density (BMD) and may have important
implications in osteoporosis prevention.

THE WORLD PREBIOTIC INGREDIENT MARKET


OBJECTIVES
MARKET

Food consumption trends


and expectations
Consumer market trends
by food segments
Prospective
MANUFACTURERS
S

Food industry
orientations
Applications in food
segments
Consumption
RESEARCH

New researches and


new developments

DESCRIPTION AND USUAL NOMENCLATURE OF THE MAIN PRODUCTS


WITH ESTABLISHED PREBIOTIC EFFECT
Generic name and structural characteristics
General abbreviation

Usual names and average DP (DPav)


General abbreviation

Inulin-type fructans
Linear (21) fructosyl-fructose
GpyFn and/or FpyFn
ITF
Short to large size polymers
(DP 2-60)
ITF-DPav12
Short Oligomers
(DP 2-8)
ITF-DPav3-4

Inulin

Large size polymers


(DP 10-60)
ITF-DPav25

High molecular weight inulin


(physical purification)
(DPav 25)
lcFOS
Mixture of oligomers and large size polymers

Mixture
(DP 2-8) + (DP 10-60)
ITF-MIX
Galactans
Mixture of (16); (13); (14) galactosylgalactose
GOS
Galn-Gal and/or Galn-Glc
(DP 2-8)
Mixture of galactans and inulin-type fructans
GOSFOS

Inulin (especially chicory inulin)


(DPav 12)
Fructo-oligosaccharides (FOS)
FOS scFOS (enzymatic synthesis from sucrose)
(DPav 3-6)
Oligofructose (enzymatic partial hydrolysis of inulin) (DPav 4)

Galacto-oligosaccharides,
trans-galacto-oligosaccharides
(enzymatic transgalactosylsation of lactose)
TOS

Galacto-oligosaccharides and high


molecular weight inulin
Usually known as GOSFOS or scGOSlcFOS

THE WORLD PREBIOTIC INGREDIENT MARKET


OBJECTIVES

OUTLOOK OF THE MARKET

MARKET

Food consumption trends


and expectations
Consumer market trends
by food segments
Prospective
MANUFACTURERS
S

Food industry
orientations
Applications in food
segments
Consumption
RESEARCH

New researches and


new developments

Oligosaccharides have begun to be


used in Japan since the beginning of
the 80's. About twenty companies
are involved in the production of
oligosaccharides in Japan which
remains the main market. Enzymatic
hydrolysis of starch and xylan are the
mostly used processes in Japan, but
other substrates are also used:
glucose,
fructose,
galactose,
hemicellulose, agar, etc ).
In the USA, insoluble fibres
represent approx. 25% of nutritional
additives and ingredients sales. This
market has grown for more than
120% from 1999 to now. Thus,
development of inulin and FOS has
been a bit slower because of
acceptance and labelling.
In Europe, we can notice theres a
strong competence in soluble

fibres segment. In 2006 there were


132 European launches of prebiotics
and
synbiotics.
There's
more
recognition of the benefits of soluble
fibres.
As fat replacer, inulin is used to
improve taste and texture with an
extra stabilizing effect on mousse
emulsion. As sugar replacer, it has a
moderately sweet taste, about 30% in
comparison with sugar, and technical
properties (viscosity, water activity,
etc) closely related to those of sugar.
Inulin and oligofructose are also used
in respect of their health benefits:
prebiotic effect and fibre effect.
Process is always an important issue
for the users: they want to avoid
changing the taste or texture; some
fibres do not resist to heat or are not
stable to acid pH.

THE WORLD PREBIOTIC INGREDIENT MARKET


OBJECTIVES

APPLICATION SEGMENTS

MARKET

Food consumption trends


and expectations
Consumer market trends
by food segments
Prospective
MANUFACTURERS
S

Food industry
orientations
Applications in food
segments
Consumption
RESEARCH

New researches and


new developments

Dairy products represent the most


important
application
segment
for
prebiotics and probiotics. Inulin is used in
low fat yoghurt, low sugar ice cream, low
fat dairy desserts, milk beverages to
improve texture and taste. Inulin is used
as a fat
replacer with an extra stabilizing effect on
mousse emulsion.
Inulin is considered by some users as an
excellent product with the added
advantage of its organoleptic properties,
providing
considerable
organoleptic
benefits through its fibrous appearance.
Oligofructose has application in low sugar
dairy products as sugar replacer.
In the confectionery, it is of particular
interest as they stabilise water exchange,
whilst their acariogenic quality is also a
major bonus. It is also appreciated for its
low calory level.

In the biscuit industry Inulin is above all


of interest for the fibre image it has with
consumers. It is used to replace
carbohydrates and leads sugar-reduced
products, products fit for diabetics, fibreenriched products, etc. Cereal use
oligosaccharides mainly for an increase
in the dietary fibre content but also for
the reduction of the amount of
carbohydrates and calories.
In many applications, inulin carries a
natural image which gives this ingredient
a preference to other molecules such as
polydextrose.

THE WORLD PREBIOTIC INGREDIENT MARKET


OBJECTIVES

REGULATION

MARKET

Food consumption trends


and expectations
Consumer market trends
by food segments
Prospective
MANUFACTURERS
S

Food industry
orientations
Applications in food
segments
Consumption
RESEARCH

New researches and


new developments

Recent international studies are leading to


the extension of definition of food fibres to
resistant oligosaccharides in all countries.
Today, most countries accept labelling
products as food fibres. In the US, inulin
was accepted Gras in 2003 and received
approval for structure-functions claims in
2005.

The accepted claims were for calcium


absorption, colon health and digestion
improvement, weight control and immune
system enhancement. Thus, no cholesterol
reduction claim is allowed so far.
Under the new EU Health Claims
regulation, a number of claims have been
submitted among which inulin and
cholesterol lowering.

THE WORLD PREBIOTIC INGREDIENT MARKET

TABLE OF CONTENTS
OBJECTIVES OF THE STUDY
12
RESEARCH METHODOLOGY
12
MARKET SIZE
12
MARKET EVALUATION
12
MARKET EXPECTATIONS
13
INTERVIEWS OF INDUSTRIAL USERS
13
1. INTRODUCTION - PREBIOTICS PRESENTATION
15
INGREDIENTS PROPERTIES
15
Non-prebiotic benefits of prebiotics
15
Immunomodulation
15
PREBIOTICS PRESENTATION
17
Definition of prebiotic effect
18
Prebiotic properties
18
Main impacts of prebiotics
22
Prebiotics and Immune system
23
Prebiotic effects in paediatrics
24
Prebiotic effects and gastro-intestinal disorders
24
Prebiotic effects and mineral absorption
25
Prebiotic effects in weight management and obesity-related disorders 26
Prebiotic effects in lowring cholesterol
27
Prebiotic production
27
Recommended daily dose
28
Food applications of prebiotics
29
GENERAL CONCLUSION AND PERSPECTIVES
30
CHICORY FRUCTANS: INULIN AND ITS ENZYMATIC HYDROLYSATE
OLIGOFRUCTOSE
31
Inulin
31
Chemical structure
33

Natural occurrence
Nutri-functional properties
Physical and Chemical Properties
Extraction and production
Recommended daily dose
Applications
FOS ( Fructo-Oligo-Saccharides)
Introduction
Occurence
FOS- Production
Purification
Safety
Clinical data
Physicochemical Properties
Techno-functional properties
FOS applications
Recommended daily dose
LACTOSE DERIVATIVES AND POLYDEXTROSES
Lactose
Generalities
Lactose - a potential prebiotic
Lactulose
Description
Nutraceutical properties
Lactitol
Nutraceutical properties
Lactosucrose
Nutraceutical properties
GOS (Galacto Oligo saccharide)
Generalities
Characteristics
GOS production
Properties

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THE WORLD PREBIOTIC INGREDIENT MARKET

TABLE OF CONTENTS
Recommended daily dose
Health properties of GOS
GOS applications
MOS (Manno Oligo Saccharide)
Composion
TOS Trans Oligosaccharides
Polydextrose
Description
Physical and chemical properties
Nutraceutical properties
Recommended dose
Technical Properties
Health Benefits of Polydextrose
Low Calories
Sugar Replacement and Lowering Glycemic Response
High/Low Glycemic Carbohydrates and the GI Factor
Benefits of a Low Glycemic Diet
Fat Reduction
Adding Soluble Fibre
Acting as a Prebiotic for Digestive Health
Increasing Satiety with Less Calories
Mineral absorption
Litesse clinical studies
Polydextrose products
Polydextrose- Applications
HMO (Human Milk Oligosaccharides)
OTHER PREBIOTICS: SOLUBLE AND INSOLUBLE FIBRES
Alginate oligosaccharides (AOS)

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Beta-glucan
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OTHER NON DIGESTIBLE OLIGOSACCHARIDES (NDO)
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Description of the products
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Nutri-functional properties of NDO
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Cyclodextrins
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2. PRODUCT COMPARISON
81
3. REVIEW OF CLINICAL DATA AND RESEARCH
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PRESENTATION
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Inulin & FOS
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Cardiovascular Diseases
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Cancer Prevention
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Diabetes Care
84
Gastrointestinal Health
84
Teeth & Bones Health
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GOS
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RESEARCH TRENDS
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Roles of probiotics
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PATENTS
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4. REGULATION
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INTRODUCTION
98
SUMMARIZING THE WORLD SITUATION
99
Labelling claims
104
Patent protection
106
REGULATION IN THE USA
109
Distinction between Dietary Supplement, Functional Food and Medicinal
Food
109
Legislation
110
Health Claims
111
Status for Inulin
112
Existing regulatory approvals for the use of gos in foods
112
Custom duties for GOS in USA
113
REGULATION IN CANADA
114
Legislation
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TABLE OF CONTENTS
Health Claims and Approval Process
Labelling of foods supplements
REGULATION IN JAPAN
Foods category in Japan
The FOSHU regulation
Procedure
REGULATION IN KOREA
REGULATION IN SOUTHEAST ASIA
REGULATION IN SOUTH AMERICA
REGULATION IN SOUTH AFRICA
REGULATION IN THE EUROPEAN UNION
Functional Foods in Europe
Infant formula
Food Labelling
Nutrition labelling
Health Claims
5. OUTLOOK OF THE MARKET
MARKET SUMMARY
World Market volumes or value by product category
Oligosaccharides and Inulin market
Lactose derivatives market size
Outlook
Prices
MARKET EVALUATION
Main food and nutritional products formulated with prebiotic
Inulin market size
Market trends

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FOS market size


Commercial available FOS
FOS- Market breakdown by Geography
The U.S Market
The Chinese Market
FOS Market by application
Lactose derivatives market size
GOS market size
Price
Packaging
GOS limitations
GOS market application
GOS application by market segment
Infant formula
Tradional food products
Animal feeds
GOS market applications by geography
LACTULOSE MARKET SIZE
Lactulose market applications
LACTITOL MARKET SIZE
LACTOSUCROSE MARKET SIZE
Lactosucrose market applications
Other prebiotics
Arabic gum market size
Polydextrose market
Marker size
Supply
Applications of Polydextrose
MARKET APPLICATIONS BY COUNTRIES
Europe
Dairy products
Synbiotics used in dairy products
Parmalat (it)

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TABLE OF CONTENTS
Infant formula
Functional foods
Beverages
Meal replacers
Confectionery
Bakery
Petfood/feed
Food supplement
Cosmetics
US
Market overview
US Inuline market
Dairy products
Functional foods
Beverages
Meal replacers / Meat
Bakery
Confectionery
Low fat/low sugar ice cream
Petfood/Feed
Food supplements
South America and Central America
Chile
Argentina
Mexico
Asia
Japan

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Korea
China
Taiwan
Thailand
Asian dairy products
Synbiotics used in dairy products
Asian infant formula
Beverages
Other food segments
Asia
China
Indonesia
Taiwan
Oceania
Food supplements
Functional foods
Infant formula
South Africa
Agave in South Africa
6. SUPPLY AND MAIN SUPPLIERS
COMPANIES PRESENTATION
OLIGOSACCHARIDE MANUFACTURERS
USA
CARGILL INC (US)
Sensus America LLC (US)
Jackson GI Medical Co (US)
Lonza Group (US)
INGREDION INCORP (US)
NATIONAL STARCH AND CHEMICAL CO (US)
GTC NUTRITION (US)
MATSUTANI AMERICA INC (US)
PURAC AMERICA EUROPE (US)
ROXLOR LLC (US)

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TABLE OF CONTENTS
JARROW FORMULA INC (US)
FENCHEM BIOTEK LTD(US)
Wacker Group(USA)
South America
NEKUTLI SA DE CV (MX)
Fine Chem (Peru)
Europe
BENEO-ORAFTI (BE)
COSUCRA SA (BE)
SENSUS (NL)
ABBOTT HEALTHCARE PRODUCTS BV(NL)
BEGHIN MEIJI INDUSTRIES (SYRAL GROUP - FR/JP)
ARLA FOOD INGREDIENTS (SW-DK)
ROQUETTE (FR)
Japan
Japanese oligosaccharides Manufacturers
MEIJI FOOD MATERIA CO LTD (JP)
SUNTORY HOLDINGS LTD(JP)
SHOWA SANGYO CO LTD (JP)
NIHON SHOKUHIN KAKO CO LTD (JP)
MITSUI SUGAR CO LTD (JP)
MIE CHEMICAL FOODS CO / MIE-KARYO(JP)
NIPPON BEET SUGAR MANUFACTURING CO LTD (JP)
NIPPON PAPER INDUSTRIES CO LTD (JP)
MATSUTANI CHEMICAL INDUSTRY CO LTD (JP)
TAKARA BIO INC (JP)
TAKARA BIO INC (JP)

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MITSUBISHI-KAGAKU FOODS CO LTD (JP)


GLICO NUTRITION LTD (JP)
B FOOD SCIENCE CO LTD (JP)
Korea
MIWON (DAESANG- KR)
CJ CHEILJEDANG CORP (KR)
China
BAOLINGBAO BIOLOGY COLTD (CN)
QINDAO UNITED INTERNATIONAL INC (CN)
YUNEHING INDUSTRIAL CO LTD (CN)
FENCHEM BIOTEK LTD(CN)
VICTORY BIOLOGY ENGINEERING CO LTD (CN)
Taiwan
HSIN-HO-MEI FRUCTOSE CO LTD (TW)
India
CHANDIGARHINDIA(IND)
GOS MANUFACTURERS
FIRST MILK LTD (UK)
KERRY INGREDIENTS (IRL)
NISSIN SUGAR MANUFACTURING CO LTD (JP)
YAKULT PHARMACEUTICAL INDUSTRY CO LTD (JP)
SAMYANG GENEX (KR)
ABO SWITZERLAND CO LTD (CN)
QINDAO FTZ UNITED INTERNATIONAL INC (CN)
NEW FRANCISCO BIOTECHNOLOGY (CN)
TERIO CO (CN)
WUXI CIMA SCIENCE CO LTD (CN)
TAIWAN
TAIWAN FRUCTOSE CO LTD (TW)
MOS MANUFACTURERS
BioMart Inc.(US)
Orffa Inc.(US)
Alltek (US)

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TABLE OF CONTENTS
Biotal Ltd. (UK)
LACTULOSE SUPPLIERS
MORINAGA MILK INDUSTRY (JP)
SOLVAY (BE)
MILEI GmbH (BE)
ILLOVO SUGAR LTD (SA)
LACTITOL SUPPLIERS
PURAC BIOCHEM (NL)
LONZA (CH)
LACTOSUCROSE SUPPLIERS
ENSUIKO SUGAR REFINING CO LTD (JP)
HAYASHIBARA CO LTD (JP)
POLYDEXTROSE SUPPLIERS
DUPONT (US)
Product
Benefit
Applications
TATE & LYLE PLC (UK)
TECHNO FOOD INGREDIENTS CO LTD (CN)
7. PROCESSING DATA
GENERAL INFORMATION
PREBIOTICS (INULIN & FOS)
RHEOLOGICAL PROPERTIES
Applications
8. ANNEX: REGULATION
U. S. FOOD AND DRUG ADMINISTRATION
EU REGULATION

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Legislation
Making a novel food dossier
Health claims
Type A: "enhanced function" claims
Type B: "reduction of disease-risk" claims
EU Health claims 2006 Directive
Federal Institute for Risk Assessment
International Regulatory Status of Polydextrose
Australia/New Zealand
Europe
Indonesia
Japan
Malaysia
Philippines
Singapore
Taiwan
Thailand
United States
Vietnam
9. PRODUCTION STATISTICS
10. IMPORT- EXPORT STATISTICS
US IMPORT AND EXPORT OF INULIN 2014
EUROPEAN IMPORT AND EXPORT OF INULIN

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THE WORLD PREBIOTIC INGREDIENT MARKET

LIST OF TABLES
Table 1. Prebiotics classification
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Table 2. Description and usual nomenclature of the main products with established prebiotic effect
21
Table 3. Food applications of prebiotics
29
Table 4Inulin content of various plants
32
Table 5Inulin content (% of fresh weight) of plants that are commonly used in human nutrition
32
Table 6Typical Examples of Food Technology Applications of Chicory Inulins
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Table 7Summary of published results on the impact of FOS supplementation on satiety and body weight
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Table 8Human studies showing Non digestibility and Subsequent Fermentation of FOS
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Table 9 Summary of published results on the impact of inulin or FOS fortification in bread on dough rheology and bread quality as determined instrumentally
and sensorally.
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Table 10 Consensus on the different functional food effects of non-digestible oligosaccharides in decreasing order of established evidence in human studies
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Table 11Physicochemical properties of sugars involved in FOS production
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Table 12 Summary of FOS nutritional and technical properties
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Table 13Sweeteners obtained by hydrogenation of simple oses, diholosides or oligosides (sugar alcohols or polyols)
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Table 14Functional properties of lactitol (from J Dairy Sci 78:2584-2589, 1995)
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Table 15. Summary of in vitro Studies with GOS
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Table 16 Litesse Polydextrose Major benefits
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Table 17. Overview of human nutrition studies investigating the prebiotic (bifidogenic) properties of different non-digestible oligosaccharides (NDO)
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Table 18. Comparison of external and internal fibre
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Table 19. Comparison of insoluble and soluble fibres
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Table 20. Patents regarding the use of oligosaccharide
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Table 21. Summary on applicable Legislation, Regulation and Guidelines
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Table 22. Labeling Claims
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Table 23. Patented Protection and confidentiality of proprietary information
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Table 24. List of approved Structure-function health claims for Inulin in USA
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Table 25. Examples of FOSHU approved products with Health Claims.
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Table 26. Prices of prebiotics
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THE WORLD PREBIOTIC INGREDIENT MARKET

LIST OF TABLES
Table 27. Current market prices of Inulin and Gums products
Table 28. Market volume by type of prebiotic and by country, 2012 - In Tons and USD
Table 29. Inuline market: breakdown by segments -2012
Table 30. Western Europe: Consumer market for prebiotic products, 2000 to 2010
Table 31 Inulin World Export 2010-2014
Table 32Inulin World Import 2010-2014
Table 33 Example of suppliers by market segment
Table 34 FOS market in US: breakdown by segments 2009-2012
Table 35 US FOS market and daily recommendations
Table 36 China FOS Export Volume in 2012 and 2013(kg)
Table 37FOS market: breakdown by segments - 2009
Table 38. Market segments and example of applications for FOS
Table 39. GOS market in metric tons/year 2012 - 2013
Table 40 Some GOS-Containing Products on the Market in Europe and Asia
Table 41Some Commercial GOS Products
Table 42 GOS prices - 2012
Table 43Main GOS producers in US
Table 44 GOS market breakdown by segments
Table 45Theorical GOS market in Infant Formula
Table 46 Theorical GOS market in Infant Formula
Table 47Uses of GOS in physico-chemical modification of foodstuff
Table 48Some main GOS producers by Countries
Table 49Lactulose market per country 2010
Table 50 Global Market Volume of Polydextrose
Table 51. Polydextrose applications
Table 52. Use of prebiotics in the European beverage industry
Table 53. Prebiotics used in the European bakery industry
Table 54. Use of prebiotics in European food supplements Europe

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LIST OF TABLES
Table 55. Use of prebiotics in the European cosmetic market
Table 56 US oligosaccharides market and daily recommendations (Inulin, FOS, GOS and MOS)
Table 57 Summary table of the major US producers of oligosaccharides (Inulin, FOS, GOS and MOS)
Table 58 Summary table of the most popular finished products using (FOS, GOS and inulin)
Table 59. Use of prebiotics in the US food supplement market
Table 60. Foods ingredients with good sales potential in Mexico
Table 61. Examples of fortified ingredients in the Mexican market
Table 62. Starches and Inulin (product code: 1108) Imports by Mexico, in Tons, 2005-2009
Table 63. Possible uses of Agave Inulin in recipes
Table 64. Production units of Agave planted in Mexico, 2009
Table 65. Oligosaccharides on the Japanese market (volume and value, 2012)
Table 66. Major synbiotic dairy products in Japan
Table 67. Use of prebiotics in the Asian beverage industry
Table 68. Use of prebiotics in the Oceanian food supplements
Table 69. Use of prebiotics in the Oceanian functional food industry
Table 70. List of importing markets for Starches and Inulin exported by South Africa, in USD thousand, 2006-2010
Table 71. List of importing markets for Starches and Inulin exported by South Africa, in Tons, 2006-2010
Table 72. Main suppliers of dairy prebiotics and product range
Table 73. Main suppliers of Lactulose and production volumes
Table 74. Main suppliers of Lactitol and product range
Table 75. Main suppliers of Lactosucrose and product range
Table 76. Prebiotics applications
Table 77. European Inulin quotas of production - 2005
Table 78 Inulin US Export/Import Value ($US) andquantity for 2014
Table 79Inulin US Import 2010-2014
Table 80 Inulin US Export 2010-2014
Table 81. Extra-European Import Exports of Inulin 2012 -2013
Table 82Intra-European Import Exports of Inulin 2012 -2013
Table 83. Intra-European exports of Inulin syrup from Austria to EU countries- 2013
Table 84 Extra-European exports of Inulin syrup from Austria to all partners- 2013

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LIST OF FIGURES
Figure 1. Schematic summary of main effects of prebiotic ingredients
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Figure 2 Enterohepatic cycling of cholesterol and bile salts
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Figure 3Schematic representation of production processes of non-digestible oligosaccharides (adapted from Sako et al., 1999).
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Figure 4Prebiotic modulates the composition of the natural ecosystem by stimulating growth of indigenous micro-organisms
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Figure 5Chemical structure of inulin compounds
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Figure 6Outline of inulin production
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Figure 7 Schematic representation of the reaction mechanism for FOS production with a fructosyltransferase derived from Aureobasidium pullulans (adapted
from (Jung et al., 1989)).
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Figure 8. Structure of Lactose
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Figure 9Structure of Lactulose
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Figure 10Functional properties of lactulose (1)
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Figure 11Functional properties of lactulose (2)
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Figure 12Nutraceutical properties of lactulose
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Figure 13Basic structure of GOS
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Figure 14Production of GOS from lactose hydrolysis
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Figure 15Formation of GOS from Lactose by -Galactosidase
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Figure 16GOS production process
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Figure 17Stability of GOS and FOS in a Soft Drink Model
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Figure 18Molecular Structure of Polydextrose
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Figure 19 Technical properties of Polydextrose
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Figure 20Health benefits of polydextrose
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Figure 21 Polydextrose : Application and Technicalfunctionalities
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Figure 22. European countries having confirmed inulin as dietary fiber
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Figure 23. Annual trends in global oligosaccharide production
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Figure 24 Number of new products containing GOS
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Figure 25Western Europe forecast consumer market for prebiotics by segment, 2005-2010
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Figure 26. Western Europe share of market for prebiotics as industrial food
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Figure 27. Lactose derivatives overview
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THE WORLD PREBIOTIC INGREDIENT MARKET

LIST OF FIGURES
Figure 28. Growth opportunities ahead for lactose and derivatives for the industry 2006-2010
Figure 29Number of new products containing GOS
Figure 30New products with Lactulose
Figure 31 US Import trends for polydextrose
Figure 32 Polydextrose export market share- 2012
Figure 33 US prebiotics breakdown 2012
Figure 34. Percentage of the Products by Health Claim FOSHU (2011)
Figure 35. Annual Gross sales of Health Foods without FOSHU (billion Yen)
Figure 36. Making a Novel Food
Figure 37: US Import/Export value per month in 2014

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